5 Things You Need to Know About Shock
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Differentiating Between Anxiety, Syncope & Anaphylaxis
Differentiating between anxiety, syncope & anaphylaxis Dr. Réka Gustafson Medical Health Officer Vancouver Coastal Health Introduction Anaphylaxis is a rare but much feared side-effect of vaccination. Most vaccine providers will never see a case of true anaphylaxis due to vaccination, but need to be prepared to diagnose and respond to this medical emergency. Since anaphylaxis is so rare, most of us rely on guidelines to assist us in assessment and response. Due to the highly variable presentation, and absence of clinical trials, guidelines are by necessity often vague and very conservative. Guidelines are no substitute for good clinical judgment. Anaphylaxis Guidelines • “Anaphylaxis is a potentially life-threatening IgE mediated allergic reaction” – How many people die or have died from anaphylaxis after immunization? Can we predict who is likely to die from anaphylaxis? • “Anaphylaxis is one of the rarer events reported in the post-marketing surveillance” – How rare? Will I or my colleagues ever see a case? • “Changes develop over several minutes” – What is “several”? 1, 2, 10, 20 minutes? • “Even when there are mild symptoms initially, there is a potential for progression to a severe and even irreversible outcome” – Do I park my clinical judgment at the door? What do I look for in my clinical assessment? • “Fatalities during anaphylaxis usually result from delayed administration of epinephrine and from severe cardiac and respiratory complications. “ – What is delayed? How much time do I have? What is anaphylaxis? •an acute, potentially -
Hypovolemic Shock and Resuscitation Piper Lynn Wall Iowa State University
Iowa State University Capstones, Theses and Retrospective Theses and Dissertations Dissertations 1997 Hypovolemic shock and resuscitation Piper Lynn Wall Iowa State University Follow this and additional works at: https://lib.dr.iastate.edu/rtd Part of the Animal Sciences Commons, Physiology Commons, Surgery Commons, and the Veterinary Physiology Commons Recommended Citation Wall, Piper Lynn, "Hypovolemic shock and resuscitation " (1997). Retrospective Theses and Dissertations. 11754. https://lib.dr.iastate.edu/rtd/11754 This Dissertation is brought to you for free and open access by the Iowa State University Capstones, Theses and Dissertations at Iowa State University Digital Repository. It has been accepted for inclusion in Retrospective Theses and Dissertations by an authorized administrator of Iowa State University Digital Repository. For more information, please contact [email protected]. INFORMATION TO USERS This manuscript has been reproduced from the microfilm master. UMI films the text directly fi-om the original or copy submitted. Thus, some thesis and dissertation copies are in typewriter &ce, while others may be from any type of computer printer. The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleedthrough, substandard margins, and improper alignment can adversely affect reproduction. In the unlikely event that the author did not send UMI a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion. Oversize materials (e.g., maps, drawings, charts) are reproduced by sectioning the original, beginning at the upper left-hand comer and continuing from left to right in equal sections with small overiaps. -
Fluid Resuscitation Therapy for Hemorrhagic Shock
CLINICAL CARE Fluid Resuscitation Therapy for Hemorrhagic Shock Joseph R. Spaniol vides a review of the 4 types of shock, the 4 classes of Amanda R. Knight, BA hemorrhagic shock, and the latest research on resuscita- tive fluid. The 4 types of shock are categorized into dis- Jessica L. Zebley, MS, RN tributive, obstructive, cardiogenic, and hemorrhagic Dawn Anderson, MS, RN shock. Hemorrhagic shock has been categorized into 4 Janet D. Pierce, DSN, ARNP, CCRN classes, and based on these classes, appropriate treatment can be planned. Crystalloids, colloids, dopamine, and blood products are all considered resuscitative fluid treat- ment options. Each individual case requires various resus- ■ ABSTRACT citative actions with different fluids. Healthcare Hemorrhagic shock is a severe life-threatening emergency professionals who are knowledgeable of the information affecting all organ systems of the body by depriving tissue in this review would be better prepared for patients who of sufficient oxygen and nutrients by decreasing cardiac are admitted with hemorrhagic shock, thus providing output. This article is a short review of the different types optimal care. of shock, followed by information specifically referring to hemorrhagic shock. The American College of Surgeons ■ DISTRIBUTIVE SHOCK categorized shock into 4 classes: (1) distributive; (2) Distributive shock is composed of 3 separate categories obstructive; (3) cardiogenic; and (4) hemorrhagic. based on their clinical outcome. Distributive shock can be Similarly, the classes of hemorrhagic shock are grouped categorized into (1) septic; (2) anaphylactic; and (3) neu- by signs and symptoms, amount of blood loss, and the rogenic shock. type of fluid replacement. This updated review is helpful to trauma nurses in understanding the various clinical Septic shock aspects of shock and the current recommendations for In accordance with the American College of Chest fluid resuscitation therapy following hemorrhagic shock. -
20Mg Spironolactone I.P…..50Mg
For the use only of a Registered Medical Practitioner or Hospital or a Laboratory. This package insert is continually updated: Please read carefully before using a new pack Frusemide and Spironolactone Tablets Lasilactone® 50 COMPOSITION Each film coated tablet contains Frusemide I.P. …….. 20mg Spironolactone I.P…..50mg THERAPEUTIC INDICATIONS Lasilactone® contains a short-acting diuretic and a long-acting aldosterone antagonist. It is indicated in the treatment of resistant oedema where this is associated with secondary hyperaldosteronism; conditions include chronic congestive cardiac failure and hepatic cirrhosis. Treatment with Lasilactone® should be reserved for cases refractory to a diuretic alone at conventional doses. This fixed ratio combination should only be used if titration with the component drugs separately indicates that this product is appropriate. The use of Lasilactone® in the management of essential hypertension should be restricted to patients with demonstrated hyperaldosteronism. It is recommended that in these patients also, this combination should only be used if titration with the component drugs separately indicates that this product is appropriate. POSOLOGY AND METHOD OF ADMINISTRATION For oral administration. The dose must be the lowest that is sufficient to achieve the desired effect. Adults: 1-4 tablets daily. Children: The product is not suitable for use in children. Elderly: Frusemide and Spironolactone may both be excreted more slowly in the elderly. Tablets are best taken at breakfast and/or lunch with a generous amount of liquid (approx. 1 glass). An evening dose is not recommended, especially during initial treatment, because of the increased nocturnal output of urine to be expected in such cases. -
When the Heart Kills the Liver: Acute Liver Failure in Congestive Heart Failure
December 14, 2009 Eu Ro PE an JouR nal oF MED I cal RE sEaRcH 541 Eur J Med Res (2009) 14: 541-546 © I. Holzapfel Publishers 2009 WHEn tHE HEaRt KIlls tHE lIvER: acutE lIvER FaIluRE In congEstIvE HEaRt FaIluRE F. H. saner1, M. Heuer1, M. Meyer1, a. canbay2, g. c. sotiropoulos1, a. Radtke1, J. treckmann1, s. Beckebaum1, c. Dohna-schwake2, s. W. oldedamink3, 4, a. Paul1 1Department of general-, visceral- and transplant surgery, university Hospital Essen, germany, 2Department of Pediatric Medicine, university Hospital Essen, germany, 3Department of surgery, university of Maastricht, netherlands, 4Department of surgery, university college london Hospital, ucl, uK Abstract gestive heart failure may be absent [5, 18]. Both, congestive heart failure as a cause of acute liver fail- chronic and acute congestive heart failure can lead to ure is rarely documented with only a few cases. hepatic dysfunction [10, 17]. although there is no although the pathophysiology is poorly under- classic pattern of abnormalities, a cholestatic bio- stood, there is rising evidence, that low cardiac output chemical profile is common, with a mild elevation in with consecutive reduction in hepatic blood flow is a total bilirubin (usually 3 g/dl), a mild elevation in al- main causing factor, rather than hypotension. In the kaline phosphatase and only occasional elevations in setting of acute liver failure due to congestive heart transaminases. another common observation is an in- failure, clinical signs of the latter can be absent, which crease in InR. the presumed causes of hepatic dys- requires an appropriate diagnostic approach. function in congestive heart failure are hepatic con- as a reference center for acute liver failure and liver gestion from venous outflow obstruction and result- transplantation we recorded from May 2003 to De- ing hypertension and decreased oxygen delivery from cember 2007 202 admissions with the primary diag- an impaired cardiac output [10]. -
Preventing Dehydration
State of New Jersey Department of Human Services Division of Developmental Disabilities DDDDDD PREVENTIONPREVENTION BULLETINBULLETIN Dehydration Dehydration is a loss of too much fluid from the body. The body needs water in order to maintain normal functioning. If your body loses too much fluid - more than you are getting from your food and liquids - your body loses electrolytes. Electrolytes include important nutrients like sodium and potassium which your body needs to work normally. A person can be at risk for dehydration in any season, not just the summer months. It is also important to know that elderly individuals are at heightened risk for dehydration because their bodies have a lower water content than younger people. Why people with Common Causes and a developmental Risk Factors for disability may be Dehydration: at a higher risk for dehydration. v Diarrhea v Vomiting v People with physical limitations may v Excessive sweating not be able to get something to drink on their own and will need the assistance of v Fever others. v Burns v People who cannot speak or whose v Diabetes when blood sugar is too high speech is hard to understand may have a v hard time telling their support staff that Increased urination (undiagnosed diabetes) they are thirsty. v Not drinking enough water, especially on warm and hot days v Some people may have difficulty swal- lowing their food or drinks and may v Not drinking enough during or after exercise refuse to eat or drink. This can make v Some medications (diuretics, blood pressure them more susceptible to becoming meds, certain psychotropic and anticonvul- dehydrated. -
Shock and Hemodynamic Monitoring
Shock and Hemodynamic Monitoring Matthew Bank, MD, FACS Assistant Professor Hofstra North Shore‐LIJ School of Medicine Director, Surgical Intensive Care Unit North Shore University Hospital I do not have any financial conflicts of interest to disclose for this presentation Shock • Multiple different strategies for classifying shock, but all forms of shock result in impaired oxygen delivery secondary to either one or both: – reduced cardiac output (cardiogenic, septic) OR – loss of effective intravascular volume (hypovolemic, neurogenic, anaphylactic, septic). Septic Shock –Gram Negative • Gram negative septic shock: —Very studied well studied in animal models —Lipopolysaccharide (LPS) in bacterial cell wall binds to LPS binding protein. —LPS‐LBP complex then binds to cell surface CD14 receptors on monocytes and macrophages. —The LPS‐LBP‐CD14 complex then activates cells via Toll‐like receptor‐4 (TLR4). —TLR4 then “activates” cells which produce a cytokine “cascade” of proinflamatory mediators. Septic Shock –Gram Negative • Tumor Necrosis Factor (TNF) – First cytokine produced in response to gram negative sepsis – Principal mediator for acute response to gram negative bacteria – Major source of TNF is from activated macrophages – High levels of TNF predict mortality and can cause apoptosis. Septic Shock –Gram Negative • Interleukin‐1 (IL‐1) – Levels of IL‐1 increase soon after TNF production in gram negative sepsis (second cytokine to be elevated) – IL‐1 produced by macrophages, neutrophils and endothelial cells – IL‐1 increases levels of next proinflammatory cytokines in cascade, IL‐2 and IL‐12. – IL‐1 does NOT cause apoptosis Septic Shock –Gram Negative • Interleukin‐10 – Anti‐inflammatory cytokine – Inhibits production of IL‐12 – Inhibits T‐cell activation Septic Shock –Gram Positive • Gram positive sepsis – Gram positive cell wall components are also known to be involved in septic response – Peptidoglycans – Teichoic Acid – Likely act in a similar manner as LPS, but less potent on a weight bases. -
The Effect of Dehydration, Hyperthermia, and Fatigue on Landing Error Scoring System Scores
ABSTRACT THE EFFECT OF DEHYDRATION, HYPERTHERMIA, AND FATIGUE ON LANDING ERROR SCORING SYSTEM SCORES Purpose: To examine the effects of exercise-induced dehydration, hyperthermia, and fatigue on Landing Error Scoring System (LESS) scores during a jump-landing task, and the effectiveness of a personalized hydration plan. Methods: Five recreationally active heat-acclimatized males 25.4 y (SD=5.7) completed two trials: with fluid replacement, (EXP) and without fluid (CON), in a counterbalanced, randomized, cross-over fashion. Exercise was terminated when gastrointestinal temperature (Tgi) = 39.5°C and fatigue ≥ 7/10, or 90 min of exercise. Percent dehydration was determined by body mass change from pre- exercise (PRE) and post-exercise (POST). Tgi, heart rate (HR), and perceived fatigue were measured PRE, during exercise, and POST. Three jump-landing tasks were filmed in the frontal and sagittal planes. An experienced grader evaluated jump-landing tasks using the LESS. Statistical Analysis: Repeated measures ANOVA assessed primary dependent and independent variables while a priori dependent t-tests evaluated pairwise comparisons. Results: No interaction, group, or time main effects were observed for LESS scores (p=0.437). POST dehydration (%) was greater in CON (M=2.59, SD=0.52) vs. EXP (M=0.92, SD=0.41; p<0.001), whereas hyperthermia (°C) (CON, M=39.29, SD=0.31, EXP, M=39.03, SD=0.61; p=0.425), and fatigue (CON, M=9, SD=1, EXP, M=9, SD=2; p=0.424) were similar. Conclusion: LESS scores were not affected by exercise-induced dehydration, hyperthermia, and fatigue, nor by a personal hydration plan. -
Hypovolemic Shock
Ask the Expert Emergency Medicine / Critical Care Peer Reviewed Hypovolemic Shock Garret E. Pachtinger, VMD, DACVECC Veterinary Specialty & Emergency Center Levittown, Pennsylvania You have asked… What is hypovolemic shock, and how should I manage it? Retroperitoneal effusion in a dog The expert says… hock, a syndrome in which clinical deterioration can occur quickly, requires careful analy- All forms of shock share sis and rapid treatment. Broad definitions for shock include inadequate cellular energy pro- a common concern: Sduction or the inability of the body to supply cells and tissues with oxygen and nutrients and remove waste products. Shock may result from a variety of underlying conditions and can be inadequate perfusion. classified into the broad categories of septic, hemorrhagic, obstructive, and hypovolemic shock.1-3 Regardless of the underlying cause, all forms of shock share a common concern: inadequate per- fusion.1,2 Perfusion (ie, flow to or through a given structure or tissue bed) is imperative for nutri- ent and oxygen delivery, as well as removal of cellular waste and byproducts of metabolism. Lack of adequate perfusion can result in cell death, morbidity, and, ultimately, mortality. Hypovolemic shock is one of the most common categories of shock seen in clinical veterinary medicine.4 In hypovolemic shock, perfusion is impaired as a result of an ineffective circulating blood volume. During initial circulating volume loss, there are a number of mechanisms to com- pensate for decreases in perfusion, including increased levels of 2,3-Bisphosphoglycerate, result- ing in a rightward shift in the oxyhemoglobin dissociation curve and a decreased blood viscosity. -
Acute Kidney Injury in Cardiogenic Shock: an Updated Narrative Review
Journal of Cardiovascular Development and Disease Review Acute Kidney Injury in Cardiogenic Shock: An Updated Narrative Review Sohrab Singh 1 , Ardaas Kanwar 2, Pranathi R. Sundaragiri 3, Wisit Cheungpasitporn 4 , Alexander G. Truesdell 5, Syed Tanveer Rab 6, Mandeep Singh 7 and Saraschandra Vallabhajosyula 8,* 1 Department of Medicine, The Brooklyn Hospital, Brooklyn, NY 11201, USA; [email protected] 2 Department of Medicine, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA; [email protected] 3 Section of Primary Care Internal Medicine, Wake Forest Baptist Health, High Point, NC 27262, USA; [email protected] 4 Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA; [email protected] 5 Virginia Heart/Inova Heart and Vascular Institute, Falls Church, VA 22042, USA; [email protected] 6 Section of Interventional Cardiology, Division of Cardiovascular Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA; [email protected] 7 Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA; [email protected] 8 Section of Cardiovascular Medicine, Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27262, USA * Correspondence: [email protected] Abstract: Acute myocardial infarction with cardiogenic shock (AMI-CS) is associated with high mortality and morbidity despite advancements in cardiovascular care. AMI-CS is associated with multiorgan failure of non-cardiac organ systems. Acute kidney injury (AKI) is frequently seen in patients with AMI-CS and is associated with worse mortality and outcomes compared to those without. The pathogenesis of AMI-CS associated with AKI may involve more factors than previously Citation: Singh, S.; Kanwar, A.; understood. -
Approach to Shock.” These Podcasts Are Designed to Give Medical Students an Overview of Key Topics in Pediatrics
PedsCases Podcast Scripts This is a text version of a podcast from Pedscases.com on “Approach to Shock.” These podcasts are designed to give medical students an overview of key topics in pediatrics. The audio versions are accessible on iTunes or at www.pedcases.com/podcasts. Approach to Shock Developed by Dr. Dustin Jacobson and Dr Suzanne Beno for PedsCases.com. December 20, 2016 My name is Dustin Jacobson, a 3rd year pediatrics resident from the University of Toronto. This podcast was supervised by Dr. Suzanne Beno, a staff physician in the division of Pediatric Emergency Medicine at the University of Toronto. Today, we’ll discuss an approach to shock in children. First, we’ll define shock and understand it’s pathophysiology. Next, we’ll examine the subclassifications of shock. Last, we’ll review some basic and more advanced treatment for shock But first, let’s start with a case. Jonny is a 6-year-old male who presents with lethargy that is preceded by 2 days of a diarrheal illness. He has not urinated over the previous 24 hours. On assessment, he is tachycardic and hypotensive. He is febrile at 40 degrees Celsius, and is moaning on assessment, but spontaneously breathing. We’ll revisit this case including evaluation and management near the end of this podcast. The term “shock” is essentially a ‘catch-all’ phrase that refers to a state of inadequate oxygen or nutrient delivery for tissue metabolic demand. This broad definition incorporates many causes that eventually lead to this end-stage state. Basic oxygen delivery is determined by cardiac output and content of oxygen in the blood. -
Hemodynamic Profiles Related to Circulatory Shock in Cardiac Care Units
REVIEW ARTICLE Hemodynamic profiles related to circulatory shock in cardiac care units Perfiles hemodinámicos relacionados con el choque circulatorio en unidades de cuidados cardiacos Jesus A. Gonzalez-Hermosillo1, Ricardo Palma-Carbajal1*, Gustavo Rojas-Velasco2, Ricardo Cabrera-Jardines3, Luis M. Gonzalez-Galvan4, Daniel Manzur-Sandoval2, Gian M. Jiménez-Rodriguez5, and Willian A. Ortiz-Solis1 1Department of Cardiology; 2Intensive Cardiovascular Care Unit, Instituto Nacional de Cardiología Ignacio Chávez; 3Inernal Medicine, Hospital Ángeles del Pedregal; 4Posgraduate School of Naval Healthcare, Universidad Naval; 5Interventional Cardiology, Instituto Nacional de Cardiología Ignacio Chávez. Mexico City, Mexico Abstract One-third of the population in intensive care units is in a state of circulatory shock, whose rapid recognition and mechanism differentiation are of great importance. The clinical context and physical examination are of great value, but in complex situa- tions as in cardiac care units, it is mandatory the use of advanced hemodynamic monitorization devices, both to determine the main mechanism of shock, as to decide management and guide response to treatment, these devices include pulmonary flotation catheter as the gold standard, as well as more recent techniques including echocardiography and pulmonary ultra- sound, among others. This article emphasizes the different shock mechanisms observed in the cardiac care units, with a proposal for approach and treatment. Key words: Circulatory shock. Hemodynamic monitorization.