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A-PDF Watermark DEMO: Purchase from www.A-PDF.com to remove the watermark ROSE PHARMACY JAIPUR GPAT / NIPER (JEE) / DI

1999

PY: Pharmaceutical Science

Duration: Three Hours Maximum Marks: 150

Q.1.1 One of the following statements for adenyl cyclase is wrong. Identify a) Is a membrane bound enzyme b) Inactivated by phosphodiestrase c) Catalyses the AMP formation d) Active only when associated with G-protein Q.1.2 Which one of the following device is used to increase the efficiency of drug delivery via aerosols? a) Tube spacer b) Metered valve c) Actuator d) Pressure valve Q.1.3 One of the uses given below for is not correct. Indicate a) Antitussive b) Analgesic c) Anti-inflammatory d) Antidiarrhoeal Q.1.4 Which one of the following is used as preservative in ophthalmic preparation? a) Benzalkonium chloride b) Phenol c) Benzoic acid d) Chlorocresol Q.1.5 The activity of one of the following is dependent on phenyl-N-alkyl piperidine moiety: a) Meperidine b) Imiperamine c) Diazepam d) Q.1.6 One of the organism mentioned below is used as a biological indicator in I.P. for ethylene oxide sterilization. Choose the correct one: a) Bacillus thermophilus b) Spores of Bacillus subtilis c) Bacillus pumilus d) Spores of Bacillus cereus Q.1.7 The most common causative organism of bacterial pneumoniae is a) Staphylococcus aureus b) Escherichia coli c) Streptococcus pneumoniae d) Mycoplasma pneumoniae Q.1.8 Creatinine clearance is used as a measurement for a) Glomerular filtration rate b) Renal excretion rate c) rate d) Passive renal excretion rate Q.1.9 Choose the correct starting material for the synthesis of Ethacrynic acid a) 2,3-dichloro phenoxy acetic acid b) 2,3-dibromo phenoxy acetic acid c) 2,3-dichloro phenoxy propionic acid d) 2,3-dichloro phenoxy butyric acid Q.1.10 Choose the correct metabolic process for phenobarbitone: a) p-Hydroxylation followed by reduction b) p-Hydroxylation followed by glucuronidation c) p-Hydroxylation followed by acetylation d) p-Hydroxylation followed by oxidation Q.1.11 Which one of the following antihistaminic is a basic a) Maleate b) hydrochloride c) hydrochloride d) hydrochloride Q.1.12 Conductivity cells are made of: a) Two silver electrodes b) Two parallel sheets of platinum c) Glass membrane with Ag/AgCl d) Sb –Sb2O3 Q.1.13 The chemical shift value is a) Proportional to field strength b) Not proportional to field strength c) Ratio of the number of Protons in each group d) Proportional to the number of Protons Q.1.14 Select theROSE equation that gives PHARMACY the rate of drug dissolution from tablet: JAIPUR a) Fick’s law b) Henderson Hasselbatch equation c) Noyes Whitney equation d) Michelis Menten equation

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Q.1.15 Energy absorbed in UV region produces changes in: a) The rotational energy of the molecule b) The vibrational energy of the molecule c) The electronic energy of the molecule d) All the three energy of the molecule Q.1.16 Dose dumping is a problem in the formulation of: a) Compressed tablets b) Suppositories c) Soft gelatin capsule d) Controlled release drug products Q.1.17 The initial distribution of a drug into the tissue is determined chiefly by: a) Rate of blood flow to the tissue b) Plasma protein binding of the drug c) Affinity for the tissue d) Stomach emptying time Q.1.18 Choose the characteristic of the epidermal cells and cuticle of leaf: a) Pitted walls with striated cuticles b) Wavy walls with striated cuticles c) Algal cell walls with smooth cuticles d) Straight walls with wavy cuticles Q1.19 hydrochloride is prepared from one of the following: a) 1-(4-chloro benzhydryl)-Pyridine and 3-methyl benzaldehyde b) 1-(2-chloro benzhydryl)- and 3-methyl benzaldehyde c) 1-(4-chloro benzhydryl)-Piperazine and 3-methyl benzaldehyde d) 1-(4-chloro benzhydryl)-Piperazine and 2-methyl benzaldehyde Q.1.20 One the following is Ex-officio member of the State Pharmacy Council: a) Chief Pharmacist of Government hospital b) Chief administrative medical officer of the state c) Registered Pharmacist d) Assistant Drug Controller Q.1.21 Phlorogucinol and Hydrochloric acid produces pink or red colour with: a) Cellulose cell walls b) Lignified cell walls c) Cutinized cell walls d) Mucilaginous cell walls Q.1.22 One of the forms mentioned below is used to issue license for wholesale of drugs other than specified in schedule C, C1 and X. Choose the correct one a) 20 B b) 20 B.B c) 21 B d) 20 A Q.1.23 Choose the correct chemical name for Chlorpromazine hydrochloride a) [3-(2-chlorophenothiazin-10-yl) propyl] diethylamine hydrochloride b) [2-(3-chlorophenothiazin-10-yl) propyl] dimethylamine hydrochloride c) [3-(2-chlorophenothiazin-10-yl) propyl] dimethylamine hydrochloride d) [3-(3-chlorophenothiazin-10-yl) propyl] diethylamine hydrochloride Q.1.24 Wavelength of a radiation is 5.0 µ. Wave number corresponding to that is a) 4000 cm-1 b) 2000 cm-1 c) 3000 cm-1 d) 1000 cm-1 Q.1.25 Choose the synthetic adrenocortical steroid, which do not occur in nature a) 11β, 17α, 21- trihydroxy-1, 4-pregnadiene-3,20-dione b) 17α, 21- dihydroxy- 1, 4-pregnadiene-3,20-dione c) 11β, 17α, 21- trihydroxy pregna-4-ene-3,20- dione d) 3-oxo17β,- hydroxy-androst-4-ene 2. Match each of the items 1 and 2 on the left with an appropriate item on the right [ABCD] and write in the specific space provided in the answer-book as shown below. Model Question:50 Q following ring systems are present in alkaloids given in a to d. Match them 1) Imidazole a) Pelleterine 2) Isoquinoline b) c) Papaverine ROSE PHARMACY d) JAIPUR Model answer- Since (1) corresponds to(a), (2) corresponds to (d). write

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Question Number (1) (2) 50 d c Q.2.1 Match the correct heterocyclic system present in the medicinal agents given in a-d

1) 5H Dibenz (b-f)azepine a) Nitrazepam 2) 1,4- dihydro-1,8-Naphthyridine-4one b) c) Impiramine d) Nalidixic acid Q.2.2 Match the titrants used for the following: 1) Paracetamol I.P. a) Perchloric acid 2) sodium tablet I.P. b) EDTA c) Ceric Ammonium sulphate d) Tetra butyl ammonium hydroxide Q.2.3 Starting material for the synthesis of Medicinal agents listed below. Match them with the correct ones from a-d: 1) 2-Amino-5-chloro-benzophenone a) 2) Butanone and ethyl cyano acetate b) Diazepam c) Prochloroperzine d) Propranolol Q.2.4 The ring structures present in the alkaloids listed below are given in a-d. Match them: 1) Codeine a) Phenanthrene 2) Ergotamine b) Indole c) Quinoline d) Iso-quinoline Q.2.5 The following terms are used to describe the parts of certain plants listed in a-d. Match them 1) Hypanthium a) Prunus communis 2) Rhytidoma b) Cinnamon bark c) Roots of Rauwolfia sepentina d) Eugenia caryophyllus Q.2.6 The chief active constituents of some umbelliferous fruits are listed in a-d. Match them with the correct plant source: 1) Foeniculum capillaceum a) Anethol 2) Anethum graveolens b) Carvone c) Khellin d) Linalool Q.2.7 Some substances used in tablet coating process are given. Match them with their correct use mentioned in a-d: 1) Shellac a) Polishing 2) Hydroxy propyl methyl cellulose b) Seal coating c) Film coating d) Sub-coating Q.2.8 Some materials used in the manufacture of pharmaceutical dosage forms are given. MatchROSE them with correct PHARMACY use mentioned in a-d: JAIPUR 1) Sorbitol a) Preservative for capsules

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2) Titanium dioxide b) Plasticizer in soft gelatin capsules c) Lubricant for tablets d) Opacifier for gelatin mass Q.2.9 Given below are the aerosol systems. Match them with their correct propellants given in a-d: 1) Aerosol for oral use a) 2) Aerosol for topical use b) Oxygen c) Methane d) Trichloro-monofluoro methane Q.2.10 Some of the applicants for immobilized enzyme system are given below. Match with the process listed in a-d 1) Amino cyclase a) N-oxidation of drugs containing hydrazine 2) Flavoprotein oxidase b) Resolution of DL-amino acids c) D-amino acid production d) Nucleotide production from RNA Q.2.11 The systematic names of the following drugs are given in a-d. Match them 1) Indomethacin a)13β-ethyl -17β hydroxyl-18,19-dinor-17α-pregn-4-en-20-yn-3-one 2) Levonorgestrol b) 13β-methyl-17α-hydroxy-18- nor-17α- pregn-4- en-20-yn-3-one c) 1-(2-chlorobenzyl)-5-ethoxy-2-methylindolyl-3-yl-acetic acid d) 1-(4-chlorobenzoyl)-5-methoxy-2-methylindolyl-3-yl-acetic acid

Q.2.12 Storage conditions as per I.P. for different preparations are given. Match them with the correct temperature prescribed: 1) Cold a) Between 20C and 80C 2) warm b) Below 200C c) Any temperature between 300C and 400C d) Above 400C Q.2.13 The wavelength of two different regions of the electromagnetic spectrum are given from a-d. Match them 1) Finger print region a) 2.5 to 8.0 µm 2) Visible region b) 8.0 to 15.0 µm c) 0.2 to 0.35 µm d) 0.4 to 0.8 µm Q.2.14 Match the correct applications mentioned in a to d with two equations: 1) Nernest equation a) Potential 2) IIkovic equation b) Migration current c) Diffusion current d) Conductance Q.2.15 Certain drug combinations are given below. Match them with correct drug interaction given in a-d: 1) Phenobarbitone and Digitoxin A a) Induction of Hepatic Microsomal enzyme under digitalisation 2) and methotraxate b) Potentiation of digitalis toxicity ROSE PHARMACY c) Less absorption of Methotraxate JAIPUR d) displacement of protein binding site increase toxicity of Methotraxate

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Q.2.16 of drugs listed below are given in a-d. Match them

1) α-methyl Dopa a) Multiple sites including α2-agonism 2) b) Catecholamine release c) Sympathetic neuronal block d) Non-selective vasodilation Q.2.17 Listed below are some important metabolic products of the drugs given in a-d Match them 1) p-Fluoro phenyl acetic acid glycine conjugate a) Paracetamol 2) Diphenyl methoxy acetic acid glutamine conjugate b) Diloxanide futoate c) d) Diphenhydramine Q.2.18 Listed below is the percentage of protein binding of some drugs given in a-d. Match them. 1) 0 % a) Oxyphenbutazone 2) 99% b) Lisnopril c) Hexabarbital d) Q.2.19 The items listed from A-D can be identified by the tests given below: 1) Coomb’s test a) Candida albicans 2) Coagulase test b) Virulent Staphylococcus aereus c) Mycobacterium tuberculosis d) Non-agglutinating antibodies

Q.2.20 For the following drugs, specific mechanism of action is given in a-d. Match them 1) a) Non- competitively inhibit the enzyme carbonic anhydrase 2) Acetazolamide b) Inhibit the co-transport of Na+ and Cl- in loop of Henle c) Competitive inhibitor of aldosterone at the receptors in the distal tubule d) Direct inhibition of Na+ and Cl- reabsorption at proximal portion Q.2.21 Given below are different schedules as per the Drugs and Cosmetic Act. Match them with items mentioned in a-d. 1) Schedule FF a) Standards for ophthalmic preparations 2) Schedule M b) Disease or ailments which a drug may not purport to prevent or cure c) Life period of drugs d) Requirement of factory premises Q.2.22 Two types of detectors are given below. Match them with the instrument given in a-d. 1) Flame ionization detector a) IR Spectrophotometer 2) Golay pneumatic detector b) UV Spectrophotometer c) Flame photometer d) Gas chromatograph

Q.2.23 Appropriate structural formulae for Monocyclic monoterpene and Bicyclic monoterpene ate given in a-d. Match them ROSE PHARMACY JAIPUR

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. .

. 1) Monocyclic monoterpene a) b) ...... OH 2) Bicyclic monoterpene c) d) CHO

. . Q.2.24 Two methods of sterilization are given for the materials listed from a-d. match them correctly: 1) Dry heat a) Rooms 2) γ-radiation b) Plastic syringes c) Talcum powder d) Intravenous admixture Q.2.25 Listed are some of the microscopic characters of bark powder obtained from the plants mentioned in a-d. Match them 1) Narrow slender lignified phloem fibres occur singly or a) Cinchona succiubra tangential rows of 205.lignified colorless narrow sub- b) Cinnamomum zeyanicum -rectangular parenchyma with small starch grains less c) Cinnamomum cassia amount of cork d) Hoarrhena antidysentrica 2) Wider phloem fibres, Larger- Starch grains, Longer fibres, Abundant cork Answer Key-1999 (Multiple Choice) 1.b 2.b 3.c 4.a 5.a 6.b 7.c 8.a 9.a 10.b 11.c 12.b 13.a 14.c 15.d 16.d 17.a 18.b 19.c 20.b 21.b 22.a 23.c 24.b 25.a Match the column 1. (1) b (2) d 2. (1) c (2) d 3. (1) b (2) a 4. (1) a (2) c 5. (1) d (2) b 6. (1) a (2) b 7. (1) b (2) c 8. (1) b (2) d 9. (1) d (2) a 10. (1) c (2) a 11. (1) d (2) a 12. (1) a (2) c 13. (1) b (2) d 14. (1) a (2) c 15. (1) a (2) d 16. (1) a (2) d 17. (1) c (2) d 18. (1) b (2) a 19. (1) d (2) b 20. (1) c (2) a 21 (1) a (2) d 22. (1) d (2) a 23. (1) c (2) a 24. (1) c (2) a 25. (1) b ROSE (2) c PHARMACY JAIPUR

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ROSE PHARMACY JAIPUR

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