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DRUG TESTING STANDARDS AND PRACTICES PROGRAM.

Uniform Classification Guidelines for Foreign Substances And Recommended Penalties Model Rule. January, 2018 (V.13.4)

 ASSOCIATION OF RACING COMMISSIONERS INTERNATIONAL – 2018.

Association of Racing Commissioners International 1510 Newtown Pike, Lexington, Kentucky, www.arci.com

Page 1 of 61 Preamble to the Uniform Classification Guidelines of Foreign Substances

The Preamble to the Uniform Classification Guidelin es was approved by the RCI Testing and Quality Assurance Program Committee (now the Drug Testing Standards and Practices Program Committee) on Augus t 26, 1991. Minor revisions to the Preamble were ma de by the Drug Classification subcommittee (now the Veterinary Pharmacologists Subcommittee) on Septemb er 3, 1991.

"The Uniform Classification Guidelines printed on t he following pages are intended to assist stewards, hearing officers and racing commissioners in evaluating the seriousness of alleged violations of and prohibited substance rules in racin g jurisdictions. Practicing equine veterinarians, s tate veterinarians, and equine pharmacologists are avail able and should be consulted to explain the pharmac ological effects of the listed in each class prior to any decisions with respect to penalities to be i mposed. The ranking of drugs is based on their phar macology, their ability to influence the outcome of a race, whether or not they have legitimate therapeut ic uses in the racing , or other evidence that they may be used improperly. These classes of drug s are intended only as guidelines and should be employed only to assist persons adjudicating facts and opini ons in understanding the seriousness of the alleged offenses. The facts of each case are always differe nt and there may be mitigating circumstances which should always be considered. These drug classificat will be reviewed frequently and new drugs will be a dded when appropriate."

Notes Regarding Classification Guideline s

• Where the use of a drug is specifically permitted b y a jurisdiction, then the jurisdiction’s rule supe rsedes these penalty guidelines.

 Regulators should be aware that a laboratory report may identify a drug only by the name of its metabo lite. The metabolite might not be listed here, but the parent compound may be.

 These classes of drugs are intended only as guideli nes and should be employed only to assist persons a djudicating facts and opinions in understanding the seriousness of the alleged offenses.

 The facts of each case are different and there may be mitigating circumstances that should be consider ed.

 These drug classifications will be reviewed periodi cally. New drugs will be added or some drugs may be reclassified when appropriate.

 Racing Commissioners International (RCI) and/or the Racing Medication and Testing Consortium (RMTC) s hould be consulted for found substances or drugs not included in these guidelines and treated as Class 1 violations warranting a Class A penalty unless otherwiseadvised.

Page 2 of 61 Classification Criteria

The RCI Drug Classification Scheme is based on 1) p harmacology, 2) drug use patterns, and 3) the appro priateness of a drug for use in the racing horse. Categorization is decided using the following gener al guidelines:

. Drugs that are known to be potent or d epressants are placed in higher classes, while thos e that have (or would be expected to have) little effect on the outcome of a race are pl aced in lower classes.

 Drug Use Patterns . Some consideration is given to placement of drugs based on practical experience with their use and t he nature of positive tests. For example, positives have in the past been a ssociated primarily with the administration of proc aine , and this has been taken into consideration in the placement of procaine into Cla ss 3 instead of Class 2 with other injectable local .

 Appropriateness of Drug Use . Drugs that clearly are intended for use in equine therapeutics are placed in lower classes. Drugs th at clearly are not intended for use in the horse are placed in higher classes, particularly if they might affect the outc ome of a race. Drugs that are recognized as legitim ately useful in equine therapeutics but could affect the outcome of a race are placed in the middle or highe r classes.

The list includes most drugs that have been reporte d as detected by racing authority laboratories in t he United States, , the United Kingdom and ot her Association of Official Racing Chemists (AORC) labo ratories, but does not include those which would se em to have no effect on the performance of the hors e or drug detectability. For example, it does not includ e , sulfonamides, vitamins, anthelmintic s, or pangamic acid, all of which have been reporte d.

The list contains many drugs that have never been r eported as detected. Usually, these are representat ives of chemical classes that have the potential fo r producing an effect, and in many cases, for which at least on e drug in that chemical class has been reported.

Most drugs have numerous effects, and each was judg ed on an individual basis. There are instances wher e there is a rather fine distinction between drugs in one category and those in the next. This is a refl ection of a nearly continuous spectrum of effects f rom the most innocuous drug on the list to the drug that is the most offensive.

Page 3 of 61 Classification Definitions

 Class 1 : and drugs that have the high est potential to affect performance and that have n o generally accepted medical use in the racing horse. Many of these agents are Drug Enforce ment Agency (DEA) schedule II substances. These inc lude the following drugs and their metabolites: , derivatives, synthetic and p sychoactive drugs, and -lik e drugs as well as related drugs, including but not limited to , , , , and . Though not used as therapeutic agents, all DEA Schedule 1 agents are included in Class 1 because they are potent sti mulant or depressant substances with psychotropic a nd often habituative actions. This class also inclu des all erythropoietin stimulating substances and their analogues.

 Class 2 : Drugs that have a high potential to affect perfor mance, but less of a potential than drugs in Class 1. These drugs are 1) not generally accepted as therapeutic agents in racing , or 2) they are therapeutic agents that have a high potential for abuse. Drugs in this class include: psychotropic dr ugs, certain nervous system and cardiovascular system st imulants, , and neuromuscular blocking a gents. Injectable local anesthetics are included in this class because of their high potential for abus e as nerve blocking agents.

 Class 3 : Drugs that may or may not have generally accepted medical use in the racing horse, but the pharmacol ogy of which suggests less potential to affect performance than drugs in Class 2. Drugs in this class include , anabolic steroi ds and other drugs with primary effects on the autonomic nervous system, procaine, with properties and the high-ceiling diure tics.

 Class 4 : This class includes therapeutic that would be expected to have less potential to affect performance than those in Class 3. Drugs in this class includes less potent ; corticos teroids; antihistamines and relaxan ts without prominent (CNS) effects; expectorants and mucolytics; hemostatics; cardiac glycosides and anti-arrhythmics; topical an esthetics; antidiarrheals and mild . This class also includes the non-steroidal anti-inflamma tory drugs (NSAIDs), at concentrations greater than established limits.

 Class 5 : This class includes those therapeutic medications that have very localized actions only, such as ant i-ulcer drugs, and certain anti-allergic drugs. The drugs are also included.

Page 4 of 61 Prohibited Practices:

A) The possession and/or use of a drug, substance or m edication, specified below, on the premises of a fa cility under the jurisdiction of the regulatory body for which a recognized analytical method has n ot been developed to detect and confirm the adminis tration of such substance; or the use of which may endanger the health and welfare of the ho rse or endanger the safety of the rider or driver; or the use of which may adversely affect the integrity of racing:

1) Erythropoietin 2) Darbepoetin 3) Oxyglobin 4) Hemopure

B) The possession and/or use of a drug, substance, or medication on the premises of a facility under the jurisdiction of the regulatory body that has not been approved by the United States Food and Dru g Administration (FDA) for use in the United States .

C) The practice, administration, or application of a t reatment, procedure, therapy or method identified b elow, which is performed on the premises of a facility under jurisdiction of a regu latory body and which may endanger the health and w elfare of the horse or endanger the safety of the rider or driver, or the use of which may adversely affect the integrity of racing:

Page 5 of 61 Drug Classification Scheme

 Class 1 : Opiates, opium derivatives, synthetic opioids, ps ychoactive drugs, amphetamines, and all DEA Schedul e I substances (see http://www.deadiversion.usdoj.gov/schedules/#list) , and many DEA Schedule II drugs. Also found in thi s class are drugs that are potent stimulants of the CNS. Drugs in this class have no generally accepted medical use in the racing horse and their pharmaco logic potential for altering the performance of a racing horse is very high. This class also includes all erythropoietin stimulating substances and thei r analogues.

 Class 2 : Drugs placed in this category have a high potenti al for affecting the outcome of a race. Most are no t generally accepted as therapeutic agents in the racing horse. Many are products intended to alt er consciousness or the psychic state of humans, an d have no approved or indicated use in the horse. Some, such as injectable local anesthetics, have le gitimate use in equine , but should not be found in a racing horse. The following groups of drugs are placed in this class:

A. partial , or -antagonists. B. Non-opiate psychotropic drugs. These drugs may have stimulant, depressant, or neuroleptic ef fects. C. Miscellaneous drugs, which might have a stimulant e ffect on the CNS. D. Drugs with prominent CNS depressant action. E. Anti-depressant and drugs, with or wi thout prominent CNS stimulatory or depressant effec ts. F. Muscle blocking drugs - those that have a direct ne uromuscular blocking action. G. Local anesthetics that have a reasonable potential for use as nerve-blocking agents (except procaine). H. Snake venoms and other biologic substances that may be used as nerve-blocking agents.

 Class 3 : Drugs placed in this class may or may not have an accepted therapeutic use in the horse. Many are dr ugs that affect the cardiovascular, pulmonary and autonomic nervous systems. They all have the po tential of affecting the performance of a racing ho rse. The following groups of drugs are placed in this class:

A. Drugs affecting the autonomic nervous system that d o not have prominent CNS effects, but which do have prominent cardiovascular or effects. Bronchodilators are included in thi s class. B. A local that has nerve-blocking potentia l but also has a high potential for producing residue levels from a method of use not related to the anesthetic effect of the drug (procaine). C. Miscellaneous drugs with mild sedative action, such as the sleep-inducing antihistamines. D. Primary vasodilating/hypotensive agents. E. Potent diuretics affecting renal function and body fluid composition. F. Anabolic and/or androgenic and other drugs .

Page 6 of 61 • Class 4 : Drugs in this category comprise primarily therape utic medications routinely used in racehorses. Thes e may influence performance, but generally have a more limited abil ity to do so. Groups of drugs assigned to this cate gory include the following:

A. Non-opiate drugs that have a mild central antipyret ic effect. B. Drugs affecting the autonomic nervous system that d o not have prominent CNS, cardiovascular, or respir atory effects: 1. Drugs used solely as topical vasoconstrictors or de congestants. 2. Drugs used as gastrointestinal antispasmodics. 3. Drugs used to void the urinary bladder. 4. Drugs with a major effect on CNS vasculature or smo oth muscle of visceral organs. C. Antihistamines that do not have a significant CNS d epressant effect. This does not include the H2 bloc king agents, which are in Class 5. D. drugs. E. Skeletal muscle relaxants. F. Anti-inflammatory drugs. These drugs may reduce pai n as a consequence of their anti-inflammatory actio n. 1. Non-steroidal anti-inflammatory drugs (NSAIDs). (As pirin-like drugs). 2. (). 3. Miscellaneous anti-inflammatory agents. G. Less potent diuretics. H. Cardiac glycosides and antiarrhythmic agents. 1. Cardiac glycosides. 2. Antiarrhythmic agents (exclusive of , bret ylium, and ). 3. Miscellaneous cardiotonic drugs. I. Topical Anesthetics - agents not available in injec table formulations. J. Antidiarrheal drugs. K. Miscellaneous drugs: 1. Expectorants with little or no other pharmacologic action. 2. Stomachics. 3. Mucolytic agents.

• Class 5 : Drugs in this category are therapeutic medication s that have very localized actions only, such as an ti-ulcer drugs, and certain antiallergic drugs. The anticoagulant drugs are als o included.

Page 7 of 61

UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES Version 13.4 (January, 2018)

ALPHABETICAL SUBSTANCE LIST

 ASSOCIATION OF RACING COMMISSIONERS INTERNATIONAL – 2018.

Association of Racing Commissioners International 1510 Newtown Pike, Lexington, Kentucky, United States www.arci.com

Page 8 of 61

ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

2-Aminoheptane Tuamine 4 B MDPV, “bath 3,4-methylenedioxypyprovalerone 1 A salts” 3-Methoxytyramine 3-MT 2 A Sectral 3 B 2 A 5 C Atrovet, Notensil, 3 B PromAce® Tylenol, Acetaminophen () 4 C Tempra, etc. Acetanilid 4 B Diamox, 4 C Vetamox Tindal 2 A Acetophenetidin () 4 B Acetylsalicylic acid () 4 C Aclovate 4 C 2 A Adrenochrome monosemicarbazone 4 B salicylate Proventil, Albuterol () 3 B Ventolin 2 B Alcuronium Alloferin 2 A

Page 9 of 61

ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Aldocortin, 4 B Electrocortin Alfenta 1 A Axert 3 A Alphaprodine Nisentil 2 A Anaxyl 2 A Xanax 2 A 2 A Althesin Saffan 2 A Regumate 4 C Mytelase, Ambenonium 3 B Myeuran Ambril, etc. 4 B Cyclocort 4 C Moduretic; 4 B Midamor Amicar, Aminocaproic acid 4 C Caprocid 4 B Aminophyllin 3 B , etc. Aminopyrine 4 B Aminoxafen, Aminoxaphe n, Apiquel, 1 A McN-742, Menocil Amisometradine Rolictron 4 B

Page 10 of 61

ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Amisulpride Solian 2 A Mitaban 3 B Elavil, Amitril, 2 A Endep Ammivin, 3 B Norvasc Amytal 2 A Asendin 2 A 2 A Amphetamine 1 A 4 B 2 A Leritine 1 A Anisine 2 A 5 D Anisotropine Valpin 4 B Antipyrine 4 B Apazone () Rheumox 4 B Apomorphine 1 A 4 B Alurate 2 A 3 A 3 B Septocaine; 2 B Ultracaine,

Page 11 of 61

ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

etc. Tenormin 3 B Atipamazole 2 B Strattera 2 A Atracurium Tracrium 2 A 3 B Azacylonol Frenque 2 A Stresnil, Suicalm, 2 A Fentaz (with ) Lioresal 4 B Veronal 2 A 2 A Beclomethasone Propaderm 4 C Megimide, 2 A Mikedimide Lotrel, Benazepril 3 A Lotensin Naturetin 4 B 2 B Benoxinate Dorsacaine 4 C Anquil 2 A Tiadipona 2 A Deprol, Benzactizine Bronchodilett 2 A en

Page 12 of 61

ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Benzocaine 4 B 2 A 2 A Tessalon, Tessalon 2 A Perles, Zonatuss Didrex 2 A Benzthiazide 4 B Benztropine Cogentin 2 A (BZP) 1 A Bepadin 4 B Betasone, 4 C etc. Kerlone 3 B Urecholine, 4 C Duvoid Esbatal 3 A Akineton 3 A Biriperone 2 A Zebeta, 3 B Bisobloc, etc. Effectin 3 A 3 A Equipoise 3 B 3 A Bretylol 3 B

Page 13 of 61

ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Brimonidine Alphagan 2 A Lexotan, 2 A Lectopam Duract 3 A Oletor, etc. 4 B Diffucord, Bromisovalum 2 A etc. Parlodel 2 A Bromodiphenhydramine 3 B Bromidol 2 A Dimetane, 3 B Disomer Brotocol 2 A Pulmacort, 4 C Rhinocort 3 A Bumex 3 B Marcaine 2 A Temgesic 2 A Wellbutrin 2 A Buspar 2 A Butacaps, (Secbutobarbitone) 2 A Butasol, etc. Butyn 2 A () Fiorinal 2 A (butyl aminobenzoate) Butesin 4 C Hostacain 2 A

Page 14 of 61

ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Butaperazine Repoise 2 A Butoctamide Listomin 2 A Stadol, 3 B Torbugesic Butoxycaine Stadacain 4 B N-Butylscopolamine 4 C 2 B Methosorb 3 A Paxor 2 A 4 C Atcand 3 B 2 B Covatine 2 A Capolen 3 B Carbacel, 3 A Conducton Lentin, Doryl 3 B Carbamezapine Tegretol 3 B Carbazochrome 4 B + levodopa Sinemet 2 A Clistin 3 B Carbromol Mifudorm 2 A 1 A Rela, Soma 2 B Carphenazine Proketazine 2 A Prazinil 2 A

Page 15 of 61

ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Carprofen Rimadyl 4 B Cartrol 3 B Septocaine; Carticaine (see articaine) Ultracaine, 2 B etc. Coreg 3 B khat, kat, qat, quat, chat, catha, 1 A Abyssinian tea, African tea Celebrex 3 B Zyrtec 4 C betaine Beta-Chlor 2 A Nactec, 2 A Oridrate, etc. Chloraldehyde (chloral) 2 A (Alpha-Chloralose) 2 A Librium 2 A Chlorhexidol 2 A Neohydrin 4 B Trancopal 2 A 2 A Chlorophenesin Maolate 4 C Nesacaine 2 A Chloroquine Avloclor 4 C

Page 16 of 61

ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Chlorothiazide Diuril 4 B Chlortriemto Chlorpheniramine 4 B n, etc. Newiplege 2 A Thorazine, 1 A Largactil Taractan 2 A Chlorthalidone Hydroton 4 B Paraflex 4 B 4 C Pletal 4 B Cimeterol 3 A Tagamet 5 D Nupercaine 2 B Celex 2 A Clanobutin 4 B Tavist 3 B Ventipulmin 3 B Clibucaine Batrax 2 A Quarezan, Clidinium 3 B Clindex, etc. Urbanyl 2 A Temovate 4 C 2 A Cloderm 4 C 4 B

Page 17 of 61

ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Clomethiazole (Chlormethiazole) 2 A Anafranil 2 A Klonopin 2 A Catapres 3 B Tranxene 2 A Clormecaine Placacid 2 A 3 A Clothiapine Entermin 2 A Trecalmo, 2 A Rize Enadel, Sepazon, 2 A Tolestan Clozaril, 2 A Leponex For cobalt concentrations of less than 25 parts per billion (ppb) of blood serum or plasma no penalty is recommended. For concentrations of 25 ppb or greater but less than 50 ppb of blood plasma or serum the recommended penalty is a written warning, the placement of the horse on the Cobalt 3 B Veterinarians List with removal from list only after a blood test confirms that the concentration is below 25 ppb of blood plasma or serum. Testing shall be paid by the owner(s) of the horse. Concentrations of 50 ppb or greater in blood plasma or serum have a recommended “B” penalty. a- 1 A

Page 18 of 61

ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

If it is determined by the State Veterinarian/Equine Medical Director; the Stewards, or the Racing Authority that the finding of or was unintentional and not Cocaine 1 A based upon an attempt to affect the outcome of a race, the Stewards or Racing Authority may elect to assign a Class B penalty to the trainer. 1 A Colchicine 4 B Conorphone 2 A Corticaine Ultracain 2 A Cortone, etc. 4 C Cromolyn Intel 5 D Crotetamide 2 A Tercian 2 A Cyclandelate Cyclospasmol 3 A Merazine 3 B Phanodorm 2 A Flexeril 4 B Surfacaine 4 C Anhydron, 4 B Renazide Pagitane 3 B Periactin 3 B Danocrine 3 B Dantrium 4 C Darbepoetin Aranesp 1 A Syncurine 2 A

Page 19 of 61

ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Dehydrochloromethyltestosterone 3 A Dembroxol (Dembrexine) Sputolysin 4 C

Demoxepam 2 A

Percortin, DOCA, Deoxycorticosterone 4 C Descotone, Dorcostrin Deremaxx 3 B 1 A Norpromine, 2 A Pertofrane Des Owen 4 C Topicort 4 C 3 A Dormosedan 3 B Azium, etc. 4 C 4 B Palfium, 1 A Narcolo Darvon 3 B Dalgan 2 A Diamorphine 1 A Valium 3 B Proglycem 3 B

Page 20 of 61

ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Nupercainal, Dibucaine 2 B Cinchocaine Febenol, 2 A Isocom Dichlorphenamide Daramide 4 C Voltaren, 4 C Voltarol Dicumarol Dicumarol 5 D Diethylpropion Tepanil, etc. 2 A Themalon 2 A Florone, 4 C Maxiflor Flu-Cortinest, 4 C etc. 3 B Crystodigin 4 B Lanoxin 4 B Parcodin 2 A 4 B Dilorazepam Briantum 2 A Cardizem 4 B 3 A Dimethisoquin Quotane 4 B Dimethylsulfoxide (DMSO) Domoso 4 C 5 C Benadryl 3 B

Page 21 of 61

ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Difenoxin, 4 B Lomotil M50/50 2 A Persantine 3 B Novin, Dipyrone Methampyro 4 B ne Norpace 4 B Divalproex Depakote 3 A Esucos 2 A Dobutrex 3 B Intropin 2 A Aricept 1 A Doxacurium Nuromax 2 A Dopram 2 A 3 A Doxans 2 A Adapin, 2 A Sinequan Decapryn 3 B Dromostanolone Drolban 3 B Inapsine, Droleptan, Innovar-Vet 2 A (with Fentanyl) 2 A

Page 22 of 61

ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Dyclonine Dyclone 4 C Dyphylline 3 B Edrophonium Tensilon 3 B Eletripan Relpax 3 A Eltenac 4 B (metabolite enaloprilat) Vasotec 3 A 2 A Endorphins 1 A Enkephalins 1 A 2 A 2 A Epinephrine 2 A mesylates ( mesylate, mesylate, and mesylate) 2 A Ergonovine Ergotrate 4 C Gynergen, 4 B Cafergot, etc. Erthrityl tetranitrate Cardilate 3 A Epogen, Erythropoietin (EPO) 1 A Procrit, etc. Brevibloc 3 B Esomeprazole Nexium 5 D

Page 23 of 61

ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Domnamid, Eurodin, 2 A Nuctalon 2 A 3 B Etanercept Enbrel 4 B Ethacrynic acid Edecrin 3 B Ethamivan 2 A 2 A Placidyl 2 A Valmid 2 A Zactane 2 A Ethopropazine Parsidol 2 A Zarontin 3 A Peganone 4 B Cardrase, 4 C Ethamide Ethylaminobenzoate () Semets, etc. 4 C Maxibolin, 3 B Organon Ethylisobutrazine Diquel 2 A Dionin 1 A Ethylnorepinephrine Bronkephrine 3 A 1 A Duranest 2 A Etifoxin Stresam 2 A

Page 24 of 61

ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Depas, 2 A Pasaden Lodine 3 B Indunox 2 A 2 A HCl M99 1 A Gaster, etc. 5 D Felbatol 3 B Plendil 4 B Fenarbamate Tymium 2 A Cincopal 3 B Myalex 2 B Pondimin 2 A Corlopam 3 B Nalfon 3 B Berotec 3 B Respiride, 3 B Respan, etc Fentanyl Sublimaze 1 A 3 B Allegra 4 C 4 C Idalon 4 B Idalon, 4 B Idarac Sedalande 2 A

Page 25 of 61

ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Fludiazepam Erispam 2 A Alforone, etc. 4 C 3 B Flumethasone Flucort, etc. 4 C Flumethiazide Ademol 4 B Sibelium 4 B Bronilide, 4 C etc. Rohypnol, Narcozep, 2 A Darkene, Hypnodorm Banamine 4 C* Synalar 4 C Licon, Lidex 4 C Fluopromazine Psyquil, Siquil 2 A Fluoresone Caducid 2 A FML 4 C Fluoroprednisolone 4 B Prozac 2 A Halotestin 3 B Depixol, Flupenthixol 2 A Fluanxol Prolixin, Permitil, 2 B Anatensol, etc.

Page 26 of 61

ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Flupirtine Katadolone 3 A Alphadrol 4 C Flurandrenolide Cordran 4 C Dalmane 2 A Froben 3 B Imap, 2 A Redeptin Flixonase, 4 C Flutide Restas 2 A Dumirox, 2 A Faverin, etc. 3 A Altram 3 B Monopril 3 A Cerebyx 3 B 3 A Lasix N/A Neurontin 3 B Reminyl 2 A Gallamine Flaxedil 2 A Gamma Aminobutryic Acid (GABA) Carolina Gold 3 B 2 A 3 A Doriden 2 A Glycopyrrolate Robinul 4 C

Page 27 of 61

ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Guaifenesin ( guiacolate) Gecolate 4 C Hylorel 3 A Ismelin 3 A Wytensin 3 B Paxipam 2 A Halog 4 C Halobetasol Ultravate 4 C Haldol 2 A Somelin 2 A Oxyglobin Hemoglobin glutamers 2 A Hemopure Corofundol 3 B 1 A Hexafluorenium Myalexen 2 A Evipal 2 A Tral 4 B Cyclaine 2 B Homapin 3 B Homophenazine Pelvichthol 2 A Hydralazine Apresoline 3 B Hydrochlorthiazide Hydrodiuril 4 B (dihydrocodienone) Hycodan 1 A () Cortef, etc. 4 C Saluron 4 B Dilaudid 1 A Hydroxyamphetamine Paradrine 1 A

Page 28 of 61

ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

4-Hydroxytestosterone 3 B Atarax 2 B Ibomal Noctal 2 A Motrin, Advil, 4 C Nurpin, etc. Corvert 3 B Ventavis 3 A Imavate, Presamine, 2 A Tofranil Indomethacin Indocin 3 B Infliximab Remicade 4 B Ipratropium 3 B Irbesarten Avapro 3 A Isapirone 2 A Marplan 2 A Isoetharine Bronkosol 3 B Predef 2x 4 C 2 A Octin, Octon 4 B Darbid 4 B Isoproterenol Isoprel 2 A Isosorbide dinitrate Isordil 3 B Maxicam 2 B Vasodilan 4 D DynaCirc 4 B

Page 29 of 61

ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Kebuzone 3 B Ketalar, Ketaset, 2 B Vetalar Anxon, Laftram, 2 A Solatran, Loftran Orudis 4 C* Toradol 3 A Normodyne 3 B Lamictal 3 A Lansoprazole 5 D Elanone-V 2 A Viscotiol, Letosteine 4 B Visiotal 3 A 2 B Betagan 3 B 2 A Levo- 1 A Dremoran Lidocaine Xylocaine 2 B Prinivil, Lisinopril 3 A Zestril Lithizine, 2 A Duralith, etc. 2 A

Page 30 of 61

ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Lofentanil 1 A Loflazepate, Ethyl Victan 2 A Imodium 3 B Dormonort, 2 A Havlane Loratidine Claritin 4 C Ativan 2 A Noctamid 2 A Losartan Hyzaar 3 B Laxitane 2 A 3 A Ludiomil 2 A Mazindol Sanorex 1 A Axiten, Dormate, 2 A Capla Inversine 3 B Antivert, 3 B Bonine Arquel 4 C Lucidiril, etc. 2 A Nobrium, etc. 2 A Domitor 3 B Medriusar, 4 C etc. Ponstel 3 B

Page 31 of 61

ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Mildronate, Meldonium 1 A et al Mobic 4 B Eunerpan 2 A Namenda 2 A Meparfynol Oblivon 2 A Mepazine Pacatal 2 A Cantil 3 B Meperidine Demerol 1 A Tolserol 4 B Control, etc. 2 A Wyamine 1 A Mesantoin 2 A Mephobarbital Mebaral 2 A () Carbocaine 2 B Equanil, 2 A Miltown Mercuhydrin 4 B Merbaphen Novasural 4 B Mercaptomerin Thiomerin 4 B Mercumatilin Cumertilin 4 B Salyrgan 4 B Mesalamine Asacol 5 C Serentil 2 A 3 A

Page 32 of 61

ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Mesterolone 3 A Talis 2 A Alupent, Metaproterenol 3 B Metaprel Aramine 1 A Skelaxin 4 B 2 A Metformin 2 B Methenolone Primobolan 3 A 3 A Dolophine 1 A Recommended Penalty B if testing can prove presence of Desoxyn 1 A4 only levo-methamphetamine is present in sample. Methandrostenolone Dianobal 3 A (Methylandrostenediol) Probolic 3 A Banthine 3 B Histadyl, etc. 3 B Quaalude 1 A Gemonil 2 A 3 A Naptazane 4 C 1 A Tacaryl 3 B Methixene Trest 3 A Robaxin 4 C Brevital 2 A

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ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Folex, Methotrexate 4 B Nexate, etc. Levoprome, Methotrimeprazine 2 A Neurocil, etc. Vasoxyl 3 A Orthoxide 3 A Methscopolamine Pamine 4 B Methsuximide Celontin 4 B 3 B Enduron 4 B 3 A Aldomet 3 A Geranamine 1 A (Methylhexaneamine) Methylergonovine Methergine 4 C Methylnortestosterone () 3 A Ritalin 1 A Medrol 4 C Metandren 3 B Methyl-1- 3 A Noludar 2 A Sansert 4 B 4 B Reglan 4 C Metubine 2 A 3 B

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ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Metomidate Hypnodil 2 A 1 A (methydihydromorphinone) Lopressor 3 B Melex 2 A Mexitil 4 B Posicor 3 B 3 B Versed 3 B Pro-Amiline 3 B Milrinon 4 B Loniten 3 B Mirtazepine Remeron 2 A Cytotec 5 D Kratom 1 A Mivacurium Mivacron 2 A Provigil 2 A Moexipril (metabolite, moexiprilat) Uniretic 3 B Moban 2 A Elocon 4 C Singulair 4 C Luvatren 2 A If it is determined by the State Veterinarian/Equine Medical Director; the Stewards, or the Racing Authority that the Morphine 1 A6 finding of cocaine or morphine was unintentional and not based upon an attempt to affect the outcome of a race, the

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ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Stewards or Racing Authority may elect to assign a Class B penalty to the trainer.

Mosaprimine 2 A 3 A myo-inositol trispyrophosphate 1 A (ITPP) Anthraxan, Relafen, 3 A Reliflex Nadol Corgard 3 B Naepaine Amylsine 2 A Nubain 2 A Nalline, 2 A Lethidrone Narcan 3 B Revia 3 B Nandrolin, Laurabolin, 3 B Durabolin Privine 4 B Equiproxen, 4 C Naprosyn Amerge 3 B 3 A Tilade 5 D Serzone 2 A

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ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Nefopam 3 A Prostigmine 3 B Cardine 4 B Procardia 4 B Nifluril 3 B Nikethamide Coramine 1 A 3 B Erimin 2 A Nemotop 4 B Mogadon 2 A Nitroglycerin 2 B Axid 5 D 19-Norandrostenediol 3 B 19-Norandrostenedione 3 B Norbolethone/ 3 A 3 A Calmday, Nordiazepam 2 A Nordaz, etc. 2 A 3 A Nortestosterone 3 B Aventyl, 2 A Pamelor Nylidrine Arlidin 3 A Olanzepine Zyprexa 2 A Olmesartan Benicar 3 A

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ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Olsalazine Dipentum 5 C Prilosec, 5 D Losec Norlfex 4 B 3 A Anavar 3 B Daypro, 4 B Deflam Serax 2 A Serenal 2 A Trileptal 3 A (hydroxyephedrine) 2 A Trasicor 3 A Percodan 1 A 3 A Afrin 4 B Adroyd, 3 B Anadrol Numorphan 1 A Oxyperitine Forit, Integrin 2 A Tandearil 4 C Daricon 4 B Oxyphenonium Antrenyl 4 B 2 A Pancuronium Pavulon 2 A Pantoprazole Protonix 5 D

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ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Papaverine Pavagen, etc. 3 A Paral 2 A Paradione 3 A Haldrone 4 C Eutonyl 3 A Paxil, Seroxat 2 A Pemoline Cylert 1 A Levatol 3 B Cyperon 2 A Pentaerythritol tetranitrate Duotrate 3 A Talwin 3 B Nembutal 2 A Trental, Pentoxyfylline 4 D Vazofirin Metrazol, Pentylenetetrazol 1 A Nioric Taxilan 2 A Perfluorodecolin 2 A Perfluorodecahydronophthalene 2 A Perfluorooctylbromide 2 A Perfluorotripropylamine 2 A Perfluorocarbons 2 A Permax 3 B Alodept, etc. 2 A Perindopril Biprel 3 A Hypnodin 2 A

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ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Perphenazine Trilafon 2 A Phenurone 4 B Acalo, 2 A Alcamid, etc. Narphen 1 A (PCP) Sernylan 1 A Bontril, etc. 1 A Nardelzine, 2 A Nardil Hedulin 5 D Preludin 1 A Luminal 2 A Dibenzyline 3 B Liquamar 5 D Milontin 4 B Iomamin 2 A Regitine 3 B Butazolidin 4 C* Isophrin, Neo- 3 B Propadrine 3 B Dilantin 4 B Eserine 3 A 1 A Alvodine, 2 A Cimadon

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ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Pimobendan 2 B Orap 2 A Domar 2 A Viskin 3 B Dipiperon 2 A Pipecuronium Arduan 2 A 2 A Psymod, 2 A Quide Metycaine 2 A Lonseren, 2 A Piportil Dataril, Gerondyl, 2 A etc. 2 A Maxair 3 B Gastrozepin 5 C Arelix, Tauliz 3 B 1 A Feldene 4 B Polyethylene glycol 5 D Renese 4 B Pramoxine Tronothaine 4 C Verstran, 2 A Centrax Minipress 3 B

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ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Delta-Cortef, 4 C etc. Meticorten, 4 C etc. Citanest 2 B Mysoline 3 B 4 C Pronestyl 4 B Procaine 3 B Pro Air 3 A Darbazine, 2 A Compazine Kemadrin 3 B Sparine 3 B Phenergan 3 B Rythmol 4 B 2 A Propantheline Pro-Banthine 3 B Proparacaine Ophthaine 4 C Propentophylline Karsivan 3 B Largon 2 A Propionylpromazine Tranvet 2 A 2 A Diprivan, 2 A Disoprivan Ravocaine 2 A Propranolol Inderal 3 B

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ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Propylhexedrine Benzedrex 4 B Prostanazol 3 A Dominal 2 A Ventaire 3 A Concordin, 2 A Triptil Axeen, 2 A Centralgol Cenafed, 3 B Novafed Mestinon, Pyridostigmine 3 B Regonol Neoantergan Pyrilamine 3 B , Equihist Hybersulfan, 2 A Sonodor Quazipam Doral 2 A Seroquel 2 A 3 A Quinapril, Quinaprilat Accupril 3 A Quinidex, 4 B Quinicardine Rabeprazole Aciphex 5 D Racemethorphan 2 A 2 A 2 A Paylean 2 A , metabolite Ramiprilat Altace 3 A

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ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Ranitidine Zantac 5 D Ultiva 1 A Roxiam 2 A Serpasil 2 B 2 A 2 A 2 A Yutopar 3 B Exelon 2 A Maxalt 3 B Rocuronium Zemuron 2 A Vioxx 2 B Sedivet 3 B Naropin 2 A 4 C Salicylate 4 C 3 B (Hyoscine) Triptone 4 C (Quinalbarbitone) Seconal 2 A Eldepryl, 2 A Jumex, etc. Lustral, 2 A Zoloft Meridia 3 B Viagra 3 A Snake Venoms 1 A

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ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Somatropin Nutropin 2 A Somatrem Protropin 2 A Betapace, 3 B Sotacor Spiclomazine 2 A 2 A Spirapril, metabolite Spiraprilat Renomax 3 A Spironalactone Aldactone 4 B Winstrol-V 3 B 3 A 1 A Sucostrin, Succinylcholine 2 A Quelin, etc. Sufenta 1 A Azulfidine, Sulfasalazine 4 C Azaline Sulfondiethylmethane 2 A 2 A Inofal 2 A Clinoril 3 B Aiglonyl, 2 A Sulpitil Barnetil 2 A Imitrex 3 B Spice, K2, Synthetic 1 A Kronic Tadalasil Cialis 3 A

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ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Talbutal Lotusate 2 A 2 A TCO2 3 B Telmisartin Micardis 3 B Restoril 2 A Alganex, etc. 3 B 3 B Hytrin 3 A Brethine, 3 B Bricanyl Seldane, 4 C Triludan Teslac 3 B Testosterone 3 B Nitoman 2 A Pontocaine 2 A 3 A Tetrahydrozoline Tyzine 4 B Musaril, 2 A Myolastin 2 A 4 B Aqualphyllin, 3 B etc. Kemithal 2 A Surital 2 A Torecan 2 A

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ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Thiopental Pentothal 2 A Dartal 2 A Majeptil 2 A Mellaril 2 A Thiosalicylate 4 B Thiothixene Navane 2 A Thiphenamil Trocinate 4 B Italprid, 2 A Luxoben, etc. Surgam 3 B Component 2 A of Telazol Tolopelon 2 A Blocardrin 3 B Tonocard 4 B Grandaxain, 2 A Seriel Priscoline 3 B 4 B Tolectin 3 B Topirimate Topamax 2 A Torsemide () Demadex 3 A Ultram 2 B Trandolapril (and metabolite, Tarka 3 B trandolaprilat) Tranexamic acid 4 C Parnate 2 A

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ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Trazodone Desyrel 2 A Finoplix 3 B Inolin 2 A Vetalog, etc. 4 C Dyrenium 4 B Halcion 2 A Tribromethanol 2 A Tricaine methanesulfonate Finquel 2 A Naqua, 4 C Naquasone Trichloroethanol 2 A Trilene, Tricholoethylene 2 A Trimar Triclos 2 A Pathilon 4 B Trifluomeprazine Nortran 2 A Stelazine 2 A Triperidol 2 A Vetame, 2 A Vesprin Trihexylphenidyl Artane 3 A Trimeprazine Temaril 4 B Tridione 3 B Trimethaphan Arfonad 3 A Surmontil 2 A PBZ 3 B

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ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Triprolidine Actidil 3 B Tubocurarine () Metubin 2 A Benvil, 2 A Nospan, etc. Urethane 2 A 2 B 3 A Nirvanyl 2 A Valsartan Diovan 3 B Levitra 3 A 4 B Efflexor 2 A Accional, 2 A Veralipril Calan, Isoptin 4 B Vercuronium Norcuron 2 A Catatrol, 2 A Vivalan, etc. Delvinol 2 A Optanox, 2 A Speda Coumadin, 5 D Coufarin Rompun, Bay 3 B Va 1470 Otrivin 4 B 2 B

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ARCI UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES – V.13.4 Trade Drug Penalty Drug/Substance Name(s) Class Class Special Notation

Zafirlukast Accolate 4 C Sonata 2 A Ralgro 4 C 1 A Zyflo 4 C hydrochloride Zilpaterol 2 A Geoden 2 A 2 A Zomig 3 B Ambien, 2 A Stilnox Zomax 2 B Zonegran 3 B Imovan 2 A Lodopin 2 A Ciatyl, 2 A Cesordinol ∆-1-androstene-3, 17-diol 3 A ∆-1-androstene-3, 17-dione 3 A ∆-1- 3 A

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Non-Classified Substances

Substances that are considered to have no effect on the physio logy of a racing animal except to improve nutrition or treat or prevent infections or parasite infestations, are not classifi ed . These Substances normally include antimicrobials, antiparasitic drugs, and nutrients such as vit am ins . Examples of such substances include the following :

Sulfonamides and trimethoprim Bufotenine 1. Note : Bufotenine is not commerically available in any fo rm .

Ant ibio t ics : 2. Note : Bufotenine is a metabolite ofS-methoxy-N- N Cephalosporins dimethyltryptamine, found in reed canary grass Chloramphenicol (and potentially other food source plants). It may Aminoglycosides be found Tetractckubes in the urine of horses eating this grass (and Nitrofurans potentially other plant foods), and has been . Findings of Metronidazole reported as a positive finding bufotenine in equine urine should not be considered for regulatory act .

Ant h elm int ics : Benzimadaziles

Antifungals Vitamins A,D,E,K,B vitamins Vitamin C

NOTE: Dimethylsulphone (MSM) has been removed from the classification document and its status is “Do N ot Report”.

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UNIFORM CLASSIFICATION OF FOREIGN SUBSTANCES Version 13.4 (January, 2018)

PENALTY GUIDELINES

 ASSOCIATION OF RACING COMMISSIONERS INTERNATIONAL – 2018.

Association of Racing Commissioners International 1510 Newtown Pike, Lexington, Kentucky, United States www.arci.com

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PENALTY CATEGORY “A”

The following are recommended penalties for violati ons due to the presence of a drug carrying a Category “A” penalty and for violations of ARCI-011-015 and ARCI-025-015: Prohibited Practices:

LICENSED TRAINER: 1st Offense 2nd LIFETIME offense in any jurisdiction 3rd LIFETIME offense in any jurisdiction • Minimum one-year suspension absent mitigating • Minimum three-year suspension absent mitigating • Minimum five-year suspension absent mitigating circumstances. The presence of aggravating factors circumstances. The presence of aggravating factors circumstances. The presence of aggravating factors could be used to impose a maximum of a three-year could be used to impose a maximum of license could be used to impose a maximum of license suspension revocation with no reapplication for a three-year revocation with no reapplication for a five-year period. period.

AND AND AND • Minimum fine of $10,000 or 10% of total purse • Minimum fine of $25,000 or 25% of total purse • Minimum fine of $50,000 or 50% of total purse (greater of the two) absent mitigating circumstance s. (greater of the two) absent mitigating circumstance s. (greater of the two) absent mitigating circumstance s. The presence of aggravating factors could be used to The presence of aggravating factors could be used t o The preence of aggravating factors could be used to impose a maximum of $25,000 or 25% of purse impose a maximum of $50,000 or 50% purse (greater impose a maximum of $100,000 or 100% purse (greater of the two). of the two). (greater of the two).

AND AND AND • May be referred to the Commission for any further • May be referred to the Commission for any further • May be referred to the Commission for any further action deemed necessary by the Commission. action deemed necessary by the Commission. action deemed necessary by the Commission. LICENSED OWNER: 2nd LIFETIME offense in owner’s stable any 3rd LIFETIME offense in owner’s stable in any st 1 Offense jurisdiction jurisdiction • Disqualification and loss of purse • Disqualification and loss of purse • Disqualification, loss of purse and $50,000 fine AND AND AND • Horse shall be placed on the Veterinarian’s List fo r • Horse shall be placed on the Veterinarian’s List fo r • Horse shall be placed on the Veterinarian’s List fo r 180 days and must pass a commission-approved 180 days and must pass a commission-approved 180 days and must pass a commission-approved examination before becoming eligible to be entered. examination before becoming eligible to be entered. examination before becoming eligible to be entered. AND • Referral to the Commission with a recommendation of a suspension for a minimum of 90 days.

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PENALTY CATEGORY “B”

The following are recommended penalties for violati ons due to the presence of a drug carrying Category “B” penalty, for the presence of more than one NSA ID a plasma/serum sample, subject to the provisions set forth in ARCI-011-020(E) and ARCI-025-020(E) and fo r violations of the established levels for total ca rbon dioxide:

LICENSED TRAINER: 1st Offense 2nd offense (365 -day period) in any jurisdiction 3rd offense (365 -day period) in any jurisdiction • Minimum 15-day suspension absent mitigating • Minimum 30-day suspension absent mitigating • Minimum 60-day suspension absent mitigating circumstances. The presence of aggravating factors circumstances. The presence of aggravating factors circumstances. The presence of aggravating factors could be used to impose a maximum of a 60-day could be used to impose a maximum of a 180-day could be used to impose a maximum of a one-year suspension suspension suspension.

AND AND • Minimum fine of $500 absent mitigating • Minimum fine of $1,000 absent mitigating • Minimum fine of $2,500 absent mitigating circumstances. The presence of aggravating factors circumstances. The presence of aggravating factors circumstances. The presence of aggravating factors could be used to impose a maximum fine of $1,000. could be used to impose a maximum fine of $2,500. could be used to impose a maximum of $5,000 or 5% purse (greater of the two).

AND • May be referred to the Commission for any further action deemed necessary by the Commission. LICENSED OWNER: 2nd offense (365-day period) in owner’s stable any 3rd offense (365-day period) in owner’s stable in any st 1 Offense jurisdiction jurisdiction • Disqualification and loss of purse [in the absence of • Disqualification and loss of purse [in the absence of • Disqualification, loss of purse, and in the absence of mitigating circumstances]* mitigating circumstances]* mitigating circumstances a $5,000 fine.* AND AND AND • Horse must pass a commission-approved • Horse must pass a commission-approved • Horse shall be placed on the Veterinarian’s List fo r examination before becoming eligible to be entered. examination before becoming eligible to be entered. 45 days and must pass a commission-approved examination before becoming eligible to be entered.

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PENALTY CATEGORY “C”

The following are recommended penalties for violati ons due to the presence of a drug carrying a Catego ry “C” penalty and overages for permitted NSAIDs an d furosemide: ( All concentrations are for measurements in serum or plasma.)

Phenylbutazone (>2.0-5.0 mcg/ml)* Phenylbutazone (>5.0 mcg/ml) Flunixin (>20 - 100 ng/ml) Flunxin (>100 ng/ml) LICENSED TRAINER Ketoprofen (>2- 50 ng/ml) Ketoprofen (>50 ng/ml) and Furosemide (>100 ng/ml) and/or CLASS C Violations no furosemide when identified as administered 1st Offense (365-day period) in any Minimum of a written warning to maximum fine of Minimum fine of $1,000 absent mitigating circumstan ces jurisdiction $500

2nd Offense (365-day period) in any Minimum of a written warning to maximum fine of Minimum fine of $1,500 and 15-day suspension absent mitigating jurisdiction $750 circumstances

3rd Offense (365-day period) in any Minimum fine of $500 to a maximum fine of $1,000 Minimum fine of $2,500 and 30-day suspension absent mitigating jurisdiction circumstances

Phenylbutazone (>2.0-5.0 mcg/ml)* Phenylbutazone (>5.0 mcg/ml) Flunixin (>20 - 100 ng/ml) Flunxin (>100 ng/ml) LICENSED OWNER Ketoprofen (>2- 50 ng/ml) Ketoprofen (>50 ng/ml) and Furosemide (>100 ng/ml) and/or CLASS C Violations no furosemide when identified as administered 1st Offense (365-day period) in any Horse may be required to pass commission-approved Disqualification and loss of purse in the absence o f mitigating jurisdiction examination before being eligible to run circumstances. Horse must pass commission-approved examination before being eligible to run. 2nd Offense (365-day period) in any Horse may be required to pass commission-approved Disqualification and loss of purse in the absence o f mitigating jurisdiction examination before being eligible to run circumstances. If same horse, placed on veterinaria n’s list for 45 days, must pass commission-approved examination bef ore being eligible to run 3rd Offense (365-day period) in any Disqualification and loss of purse. Horse must pass Disqualification and loss of purse in the absence o f mitigating jurisdiction commission-approved examination before being eligib le to circumstances. Minimum $5,000 fine. If same horse, placed on run veterinarian’s list for 60 days, must pass commissi on-approved examination before being eligible to run

*If the trainer has not had more than one violation within the previous two years, the Stewards/Judges are encouraged to issue a warning in lieu of a fin e provided the reported level is below 3.0 mcg/ml absent of aggravating factors.

After a two-year period, if the licensee has had no further violations, any penalty due to an overage in the 2.0-5.0 category will be expunged from the l icensee’s record for penalty purposes.

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PENALTY CATEGORY “D”

The recommended penalty for a violation involving a drug that carries a Category “D” penalty is a written warning to the trainer and owner. Multiple violations may result in fines and/or suspension.

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MMV Point System Multiple Medication Violation Model Rule. ARCI-011-020 (B)(13)

Officials are advised to check a licensee’s ARCI regulatory record to see if multiple medication violations should be considered as an aggravating factor in the determination of an appropriate penalty.

(1) Multiple Medication Violations (MMV) (a) A trainer who receives a penalty for a medication violation based upon a horse testing positive for a Class 1-5 medication with Penalty Class A-C, as provided in the most recent version of the ARCI Uniform Classification Guidelines for Foreign Substances, or similar state regulatory guidelines, shall be assigned points as follows:

Points If Controlled Points If Non-Controlled Penalty Class Therapeutic Substance Substance Class A N/A 6 Class B 2 4 ½ for first violation with 1 for first violation with an additional ½ point for an additional ½ point for Class C each additional violation each additional violation within 365 days 1 within 365 days Class D 0 0 1 Points for NSAID violations only apply when the prima ry threshold of the NSAID is exceeded. Points are no t to be separately assigned for a stacking violation .

If the Stewards or Commission determine that the violation is due to environmental contamination, they may assign lesser or no points against the trainer based upon the specific facts of the case.

(b) The points assigned to a medication violation by the Stewards or Commission ruling shall be included in the ARCI official database. The ARCI shall record points consistent with Section 13(a) including when appropriate, a designation that points have been suspended for the medication violation. Points assigned by such regulatory ruling shall reflect, in the case of multiple positive tests as described in paragraph

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(d), whether they constitute a single violation. The Stewards’ or Commission Ruling shall be posted on the official website of the Commission and within the official database of the Association of Racing Commissioners International. If an appeal is pending, that fact shall be noted in such Ruling. No points shall be applied until a final adjudication of the enforcement of any such violation.

(c) A trainer’s cumulative points for violations in all racing jurisdictions shall be maintained by the ARCI. Once all appeals are waived or exhausted, the points shall immediately become part of the trainer’s official ARCI record and shall be considered by the Commission in its determination to subject the trainer to the mandatory enhanced penalties by the Stewards or Commission as provided in this regulation.

(d) Multiple positive tests for the same medication incurred by a trainer prior to delivery of official notice by the commission may be treated as a single violation. In the case of a positive test indicating multiple substances found in a single post-race sample, the Stewards may treat each substance found as an individual violation for which points will be assigned, depending upon the facts and circumstances of the case.

(e) The official ARCI record shall be used to advise the Stewards or Commission of a trainer’s past record of violations and cumulative points. Nothing in this administrative regulation shall be construed to confer upon a licensed trainer the right to appeal a violation for which all remedies have been exhausted or for which the appeal time has expired as provided by applicable law.

(f) The Stewards or Commission shall consider all points for violations in all racing jurisdictions as contained in the trainer’s official ARCI record when determining whether the mandatory enhancements provided in this regulation shall be imposed.

(g) In addition to the penalty for the underlying offense, the following enhancements shall be imposed upon a licensed trainer based upon the cumulative points contained in his/her official ARCI record:

Points Suspension in days 5-5.5 15 to 30 6-8.5 30 to 60 9-10.5 90 to 180 11 or more 180 to 360

MMV penalties are not a substitute for the current penalty system and are intended to be an additional uniform penalty when the licensee: (i) Has had more than one medication violation for the relevant time period, and (ii) Exceeds the permissible number of points.

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The Stewards and Commission shall consider aggravating and mitigating circumstances, including the trainer’s prior record for medication violations, when determining the appropriate penalty for the underlying offense. The MMP is intended to be a separate and additional penalty for a pattern of violations.

(h) The suspension periods as provided in Section 13(g) shall run consecutive to any suspension imposed for the underlying offense.

(i) The Stewards’ or Commission Ruling shall distinguish between the penalty for the underlying offense and any enhancement based upon a Stewards or Commission review of the trainer’s cumulative points and regulatory record, which may be considered an aggravating factor in a case.

(j) Points shall expire as follows:

Penalty Classification Time to Expire A 3 years B 2 years C 1 year

In the case of a medication violation that results in a suspension, any points assessed expire on the anniversary date of the date the suspension is completed.

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NSAID STACKING MODEL RULE ARCI-011-020 (E)

E. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) (1) The use of NSAIDs shall be governed by the following conditions: (a) (BLANK) (b) NSAIDs included in the ARCI Controlled Therapeutic Medication Schedule, Version 2.2, are not to be used in a manner inconsistent with the restrictions contained therein. NSAIDs not included on the ARCI Controlled Therapeutic Medication Schedule, Version 2.2, are not be present in a racing horse biological sample at the laboratory concentration of detection. (c) The presence of more than one NSAID may constitute a NSAID stacking violation consistent with the following restrictions: A. A Class 1 NSAID Stacking Violation (Penalty Class B) occurs when: i. Two non-steroidal anti-inflammatory drugs are found at individual levels determined to exceed the following restrictions: a. Diclofenac – 5 nanograms per milliliter of plasma or serum; b. Firocoxib - 20 nanograms per milliliter of plasma or serum; c. Flunixin – 20 nanograms per milliliter of plasma or serum; d. Ketoprofen – 2 nanograms per milliliter of plasma or serum; e. Phenylbutazone – 2 micrograms per milliliter of plasma or serum; or f. all other non-steroidal anti-inflammatory drugs – laboratory concentration of detection ii. Three or more non-steroidal anti-inflammatory drugs are found at individual levels determined to exceed the following restrictions: a. Diclofenac – 5 nanograms per milliliter of plasma or serum; b. Firocoxib - 20 nanograms per milliliter of plasma or serum; c. Flunixin – 3 nanograms per milliliter of plasma or serum; d. Ketoprofen – 1 nanograms per milliliter of plasma or serum; e. Phenylbutazone – 0.3 micrograms per milliliter of plasma or serum; or f. all other non-steroidal anti-inflammatory drugs – laboratory concentration of detection.

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B. A Class 2 NSAID Stacking Violation (Penalty Class C) occurs when: i. Any one substance noted in Subsection (A)(i) above is found in excess of the restrictions contained therein in combination with any one of the following substances at levels below the restrictions so noted but in excess of the following levels: a. Flunixin – 3 nanograms per milliliter of plasma or serum; b. Ketoprofen – 1 nanogram per milliliter of plasma or serum; or c. Phenylbutazone – 0.3 micrograms per milliliter of plasma or serum;

C. A Class 3 NSAID Stacking Violation (Penalty Class C, fines only) occurs when: i. Any combination of two of the following non-steroidal anti-inflammatory drugs are found at or below the restrictions in Subsection (A)(i)(a through e) above but in excess of the noted restrictions: a. Flunixin – 3 nanograms per milliliter of plasma or serum; b. Ketoprofen – 1 nanogram per milliliter of plasma or serum; or c. Phenylbutazone – 0.3 micrograms per milliliter of plasma or serum;

(2) Any horse to which a NSAID has been administered shall be subject to having a blood and/or urine sample(s) taken at the direction of the official veterinarian to determine the quantitative NSAID level(s) and/or the presence of other drugs which may be present in the blood or urine sample(s).

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