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(12) United States Patent (10) Patent No.: US 9,358,393 B1 L0zano (45) Date of Patent: Jun

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(12) United States Patent (10) Patent No.: US 9,358,393 B1 L0zano (45) Date of Patent: Jun US00935.8393B1 (12) United States Patent (10) Patent No.: US 9,358,393 B1 L0ZanO (45) Date of Patent: Jun. 7, 2016 (54) STIMULATION METHODS AND SYSTEMS 4,203,440 A 5/1980 Theeuwes FORTREATING AN AUDITORY 4,203.442 A 5/1980 Michaels DYSFUNCTION 4,210,139 A 7/1980 Higuchi (Continued) (76) Inventor: Andres M. Lozano, Toronto (CA) FOREIGN PATENT DOCUMENTS (*) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 WO WOO1,08617 A1 2/2001 U.S.C. 154(b) by 1826 days. OTHER PUBLICATIONS (21) Appl. No.: 11/271,126 Office action dated Sep. 16, 2009 for related U.S. Appl. No. 1 1/271,688 (Lozano-1), filed Nov. 9, 2005, Inventor: Andres M. (22) Filed: Nov. 9, 2005 Lozano, (14 pages). Related U.S. Application Data (Continued) (60) gynal application No. 60/626,174, filed on Nov. Primary Examiner — Nicole F Lavert s (74) Attorney, Agent, or Firm — Faegre Baker Daniels LLP (51) Int. Cl. A61N L/00 (2006.01) (57) ABSTRACT A6 IB5/02 (2006.01) Methods of treating auditory hallucinations, hyperacusis, A6 IN L/36 (2006.01) Schizophrenia, and/or phonophobia include applying at least A61N L/05 (2006.01) one stimulus to a stimulation site within a patient with an (52) U.S. Cl. implanted stimulator in accordance with one or more stimu CPC .......... A61N I/36132 (2013.01); A61N I/0541 lation parameters. The stimulation site may include, for (2013.01) example, at least one or more of a cochlear nucleus, auditory (58) Field of Classification Search striae, Superior olivary complex, lateral lemniscus, inferior USPC ....................................... 607/55, 57; 600/372 colliculus, brachium of the inferior colliculus, medial genicu See application file for complete search history. late body, primary auditory cortex, secondary auditory corti cal area, and auditory radiation. Systems for treating auditory (56) References Cited hallucinations, hyperacusis, Schizophrenia, and/or phono phobia include an implanted Stimulator configured to apply at U.S. PATENT DOCUMENTS least one stimulus to a stimulation site within a patient in 3,760,984 A 9, 1973 Theeuwes accordance with one or more stimulation parameters. The 3,845,770 A 11/1974 Theeuwes et al. stimulation site may include, for example, at least one or more 3,916,899 A 11/1975 Theeuwes et al. of a cochlear nucleus, auditory striae, Superior olivary com 3,923,426 A 12/1975 Theeuwes et al. plex, lateral lemniscus, inferior colliculus, brachium of the 3,987,790 A 10, 1976 Eckenhoff et al. inferior colliculus, medial geniculate body, primary auditory 3,995,631 A 12/1976 Higuchi et al. 4,016,880 A 4, 1977 Theeuwes et al. cortex, secondary auditory cortical area, and auditory radia 4,036,228 A 7, 1977 Theeuwes tion. 4,111.202 A 9, 1978 Theeuwes 4,111,203 A 9, 1978 Theeuwes 3 Claims, 9 Drawing Sheets OUTEREAR 7 MDDEEAR/ NNEREAR7 62 64 66 US 9,358,393 B1 Page 2 (56) References Cited 6,770,067 B2 8/2004 Lorenzen et al. 6,915, 166 B1* 7/2005 Stecker et al. .................. 6O7/55 U.S. PATENT DOCUMENTS 6,993,392 B2* 1/2006 Nicolelis et al. 607,45 7,292,892 B2 * 1 1/2007 Litvak et al. .................... 6O7. 57 4,284.856 A * 8/1981 Hochmair et al. ................ 607.9 2004/0236390 A1* 11/2004 Dadd et al. ...................... 6O7/55 4,327,725 A 5, 1982 Cortese et al. 2005, 0070971 A1* 3, 2005 Fowler et al. ... 607,45 4,360,019 A 11, 1982 Portner et al. 2006/0217784 A1* 9, 2006 Kitazawa et al. 6O7. 57 4.487,603 A 12/1984 Harris 2007/0043403 A1* 2/2007 Blamey et al. 6O7/55 4,562,751 A 1, 1986 Nason et al. 2007/0106344 A1* 5/2007 Darley et al. 6O7/55 4,627,850 A 12/1986 Deters et al. 2007/0129772 A1* 6, 2007 Loeb ........ 6O7. 57 4,678.408 A 7, 1987 Nason et al. 2007/0255344 A1* 1 1/2007 Van Dijk ......................... 6O7. 57 4,685,903. A 8, 1987 Cable et al. 4,692,147 A 9/1987 Duggan OTHER PUBLICATIONS 2. A 33.6 ERF Office Action dated May 25, 2010 for related U.S. Appl. No. 5,0573 is A 10/1991 Magruder et al, 1 1/271,688 (Lozano-1), filed Nov. 9, 2005, Inventor: Andres M. 5,059,423. A 10/1991 Magruder et al. Lozano, (9 pages). 5,069,210 A * 12/1991 Jeutter et al. .................... 6O7/57 Office Action dated Aug. 10, 2010 for related U.S. Appl. No. 5,080,653 A 1/1992 Voss et al. 1 1/271,688 (Lozano-1), filed Nov. 9, 2005, Inventor: Andres M. 5,097,122 A 3, 1992 Colman et al. Lozano, (5 pages). 5,112,614 A 5/1992 Magruder et al. Non-Final Office Action dated Apr. 1, 2008 issued from related U.S. 5,137,727 A 8, 1992 Eckenhoff Appl. No. 1 1/271,688; Inventor: Andres M. Lozano (12 pages). 5, 193,539 A 3, 1993 Schulman et al. Adams DA, Wilmont T.J. Meniere's disease: long-term results of 5, 193,540 A 3, 1993 Schulman et al. sympathectomy. J Laryngol Otol 1982; 96:705-10. 5,234,692 A 8/1993 Magruder et al. DeRidder D. DeMulder G. Walsh V. Muggleton N. Sunaert S. Moller 5,234,693. A 8/1993 Magruder et al. A. Magnetic and electrical stimulation of the auditory cortex for 5,312.439 A 5, 1994 Loeb intractable tinnitus. Case report. J Neuros. 5,496,369 A 3/1996 Howard, III Heller AJ. Classification and epidemiology of tinnitus. Otolaryngol 5,501,703 A 3, 1996 Holsheimer et al. Clin North Am 2003:36:239-48. 5,676,655 A 10/1997 Howard, III et al. Ito J. Sakakihara J. Suppression of tinnitus by cochlear implantation. 5,697,975 A 12/1997 Howard, III et al. Am J Otolaryngol 1994; 15:145-8. 5,713,847 A 2/1998 Howard, III et al. Jastreboff PJ, Jastreboff MM. Tinnitus retraining therapy for patients 5,728,396 A 3/1998 Peery et al. with tinnitus and decreased sound tolerance. Otolaryngol Clin North 5,735,885 A 4, 1998 Howard, III et al. Am 2003; 36:321-36. 5,776,172 A * 7/1998 Schulman et al. .............. 6O7/56 5,938,688 A 8, 1999 Schiff Johnson RM, Brummett R, Schleuning A. Use of alprazolam for 5,938,691 A * 8, 1999 Schulman et al. .............. 607/57 relief of tinnitus. A double-blind study. Arch Otolaryngol Head Neck 5,975,085 A * 1 1/1999 Rise .............................. 128/898 Surg 1993; 119:842-5. 6,016,449 A 1/2000 Fischell et al. Moller AR. Pathophysiology of tinnitus. Otolaryngol Clin North Am 6,051,017 A 4/2000 Loeb et al. 2003:36:249-66, v.-vi. 6,164,284 A 12/2000 Schulman et al. Moller AR. Similarities between severe tinnitus and chronic pain. J 6,176,242 B1 1/2001 Rise Am Acad Audiol 2000; 11:115-24. 6,185,452 B1 2, 2001 Schulman et al. Moller MB, Moller AR, Jannetta PJ, Jho HD. Vascular decompres 3.4. r. I R ck 3.299; ShiaCilleOV . et. al.. 623, 10 sion Surgery for severe Z.tinnitus: selection criteria and results. 6,216,040 B1 * 4/2001 E. 6O7/57 R.S.E. v. JA. Evaluation of a tinnitu 6,272,3826.219,580 B1* 4/20018/2001 Faltys et al. 6O7/57 maskingenluning program: Alonson a follow-up KMYeron. study of 598 Evaluationpatients. Ear of Hear unnels 1980; 6,289.247 B1 * 9/2001 Faltys et al...................... 607/57 1:71-4. 6,308.101 B1 10/2001 Faltys et al. Schleuning AJ, Johnson RM. Use of Masking for Tinnitus. Int Tin 6,368,315 B1 4/2002 Gillis et al. nitus J 1997; 3:25-29. 6,381,496 B1 4/2002 Meadows et al. Seidman MD, Babu S. Alternative medications and other treatments 6,390,971 B1* 5/2002 Adams et al. ................... 600/25 for tinnitus: facts from fiction. Otolaryngol Clin North Am 2003; 6,430,443 B1* 8/2002 Karell ......... ... 607/55 36:359-81. 6,456,886 B1* 9/2002 Howard et al. ................. 6O7/55 Sterrnerson RL, Cronin GW. Tinnitus reduction using transcutaneous 6,487446 B1 1 1/2002 Hill et al. electrical stimulation. Otolaryngol Clin North Am 2003; 36:337-44. 6,516,227 B1 2, 2003 Meadows et al. Tasker RR. Auditory system. In: Tasker RR, ed. The thalamus and 3. R 338 SE, al midbrain of man : a physiological atlas using electrical stimulation: 6,572,531 B2 * 6/2003 Zilberman et al. .............. 60025 C.C. Thomas, 1982,200-215. 6,620, 151 B2 9, 2003 Blischak Vernon JA, Meikle MB. Masking devices and alprazolam treatment 6,656,172 B1 12/2003 Hildebrand for tinnitus. Otolaryngol Clin North Am 2003; 36:307-20, vii. 6,666,845 B2 12/2003 Hooper et al. Office Action dated Mar. 4, 2009, for U.S. Appl. No. 1 1/271,688, 6,732,073 B1* 5/2004 Kluender et al. ............. TO4,233 Inventor: Andres M. Lozano, (Lozano-1) (12 pages). 6,740,072 B2 5, 2004 Starkweather et al. 6,760,626 B1 7/2004 Boveja * cited by examiner U.S. Patent Jun. 7, 2016 Sheet 1 of 9 US 9,358,393 B1 y EAR ty EAR y EAR 62 64 66 FIG 1A U.S. Patent Jun. 7, 2016 Sheet 2 of 9 US 9,358,393 B1 Auditory Cortex (209) Transverse temporal gyrus Temporai lobe Superior cofficulus Medial geniculate body (208) Ethe E.
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