From hospital to home, a patient support program for YUPELRI® (revefenacin) inhalation solution is within reach

What is YUPELRI®? • YUPELRI is a prescription medicine used to treat chronic obstructive pulmonary disease (COPD), a long-term (chronic) lung disease that includes chronic bronchitis, emphysema, or both. • It is an anticholinergic medicine which helps the muscles around the airway in your lungs stay relaxed to prevent symptoms such as wheezing, cough, chest tightness, and shortness of breath. • It is used long-term as 1 vial of YUPELRI, 1 time each day inhaled through your nebulizer to improve symptoms of COPD for better breathing. Please see pages 6-9 for full Important Safety Information. You’ve got Care Within Reach Welcome home Once enrolled in Care Within Reach, you will have support and resources that can get you started with YUPELRI and help you stay on track while following your doctor’s instructions. Here’s what you can expect once you have decided to enroll in the Care Within Reach program. From day one with YUPELRI ® (revefenacin) inhalation solution, Care Within Reach is here to support you from the hospital to We’ll call you your home • If you choose, you will receive a call in the hospital You’ve been prescribed YUPELRI, and now you’re ready to continue treatment confirming your enrollment and date of discharge while following your doctor’s instructions in the comfort of your own home. • After you leave the hospital, you’ll receive a call to check Care Within Reach supports you from the beginning, starting with your free, that you’ve received your free, 7-day trial of YUPELRI 7-day trial of YUPELRI shipped to your home. We can provide education shipped to your home about COPD management and, if you choose, will provide regular reminders • We’ll check in with you monthly for the first 3 months of about taking and refilling your medication. the program (you may opt out at any time) • You will receive text refill reminders (if you opt in) • We will provide educational calls about COPD Taking your medication once daily is important. REMEMBER, management WE’RE HERE If you have questions or need assistance, reach out to us Monday to Friday 8 AM to 8 PM EST. • We’ll remind you about the importance of refilling and FOR SUPPORT Call 1-888-YUPELRI (987-3574) taking maintenance medications, as directed by your healthcare team. Refill reminders can be sent throughout the first year (if you opt in, you can opt out at any time)

Important Safety Information What else does Care Within Reach help you with? Who should not use YUPELRI? • Help with getting a standard jet nebulizer to use at home • Do not use YUPELRI if you have sudden breathing problems. Always have a rescue inhaler with you. (if you’re eligible—you don’t have medical insurance, or if your current commercial insurance does not cover the • Do not use YUPELRI if you have had an allergic reaction to revefenacin, or any of the other ingredients in YUPELRI (sodium chloride, citric acid, sodium citrate). standard jet nebulizer) • Do not use in children. It is not known if YUPELRI is safe and effective • Arranging a visit in your home by a trained Respiratory in children. Therapist (RT), who can help educate you on the proper use Please see pages 6-9 for full Important Safety Information. of your standard jet nebulizer 2 3 You and your doctor chose YUPELRI® (revefenacin) Coverage and support information inhalation solution YUPELRI and a standard jet nebulizer are expected to be covered by Medicare Part B* If you’re 65 years of age or older, Medicare Part B may cover YUPELRI and a standard jet nebulizer used to deliver your medicine • Medicare Part B, with secondary, Medicare supplemental, or Medi-gap As with any medication, it’s important to take YUPELRI as directed by your insurance, may reimburse up to 100% of your YUPELRI prescription healthcare provider. Here’s what’s important to remember about taking YUPELRI. • Most nebulizers are considered durable medical equipment (DME), Take YUPELRI every day which is covered by Medicare • YUPELRI works best when you use it every day at home or on the go • For questions about your medication, contact your doctor. For questions about your standard jet nebulizer or insurance coverage, contact your DME • Any standard jet nebulizer with a mouthpiece delivers YUPELRI to your supplier, local retail pharmacist, or call the number on the back of your lungs in a mist you inhale insurance card • It takes about 8 minutes to take the full dose (does not include setup *No guarantee of coverage in any setting of care. For more information, check with your or cleanup time) insurance provider. In certain limited instances YUPELRI may be covered through a patient’s Medicare Part D pharmacy benefit. Important Safety Information Commercially insured patients may Before using YUPELRI, tell your healthcare provider about all your Pay as little as save with the YUPELRI Savings Card $0 for 30 days medical conditions, including if you: of therapy Eligible patients can save up to $550 per 30-day prescription up to For eligible commercially insured patients, this 12 times per calendar year, with a max yearly savings of $6,600. •  Not valid for patients enrolled in federal or state healthcare have eye problems such as glaucoma. YUPELRI may make your programs, such as Medicare, Medicaid, and TRICARE, and RxBIN: 610524 not valid for uninsured patients (except for commercially RxPCN: Loyalty insured patients without coverage for YUPELRI® (revefenacin) Savings Card can be used to reduce the amount inhalation solution). For full terms and conditions, visit glaucoma worse. RxGRP: 50777791 http://www.YUPELRI.com/copay. ISSUER: (80840) of their out-of-pocket expense up to a maximum The YUPELRI name and the YUPELRI logo are registered trademarks of Mylan ID: 0000000000 Specialty L.P. MYLAN and the Mylan logo are registered trademarks of Mylan Inc. • have prostate or bladder problems, or problems passing THERAVANCE® and the Cross/Star logo are registered trademarks of the Theravance Biopharma group of companies. © 2019 Mylan Specialty L.P. All rights reserved. urine. YUPELRI may make these problems worse. of $550 per 30-day prescription up to a total of 12 times per calendar year, with a benefit cap of $6,600 per calendar year. • have liver problems. Valid prescription with Prescriber ID # required.† • are allergic to any of the ingredients in YUPELRI, or any other medicines. †Eligibility restrictions apply. Please see full terms and conditions at YUPELRI.com. This offer is not valid for patients covered by Medicare, Medicaid, or any other federal or state-funded • are pregnant or planning to become pregnant. healthcare program or where prohibited by law. Mylan Specialty L.P. reserves the right to amend It is not known if YUPELRI may harm your or end this program at any time without notice. unborn baby. • are breastfeeding. It is not known if the If You Are Uninsured medicine in YUPELRI passes into your You may qualify for the Mylan Patient Assistance Program.‡ breast milk and if it can harm your baby. • For more information, please email or call below: Please see pages 6-9 for [email protected] 1-800-796-9526 full Important Safety Information. ‡You must meet financial and other program-specific criteria to be eligible for assistance. 4 5 Important Safety Information • are pregnant or planning to become pregnant. It is not known if YUPELRI may harm your unborn baby. • are breastfeeding. It is not known if the medicine in YUPELRI passes into your breast milk and if it can harm your baby.

Tell your healthcare provider about all the medicines you take including What is YUPELRI® (revefenacin)? prescription and over-the-counter medicines, vitamins, and herbal supplements. YUPELRI and certain other medicines may interact with each • YUPELRI is a prescription medicine used to treat chronic obstructive other. This may cause serious side effects. pulmonary disease (COPD), a long-term (chronic) lung disease that includes chronic bronchitis, emphysema, or both. Especially tell your healthcare provider if you take: • It is an anticholinergic medicine which helps the muscles around the airway • Other anticholinergics (including tiotropium, ipratropium, aclidinium, in your lungs stay relaxed to prevent symptoms such as wheezing, cough, umeclidinium, glycopyrrolate) chest tightness, and shortness of breath. • Atropine • It is used long-term as 1 vial of YUPELRI, 1 time each day inhaled through Know the medicines you take. Keep a list of them to show your healthcare your nebulizer to improve symptoms of COPD for better breathing. provider and pharmacist each time you get a new medicine. Who should not use YUPELRI? What are the possible side effects with YUPELRI? • Do not use YUPELRI if you have sudden breathing problems. Always have YUPELRI can cause serious side effects, including: a rescue inhaler with you. • Sudden breathing problems immediately after inhaling your medicine. • Do not use YUPELRI if you have had an allergic reaction to revefenacin, If you have sudden breathing problems immediately after inhaling your or any of the other ingredients in YUPELRI (sodium chloride, citric acid, medicine, stop using YUPELRI and call your healthcare provider right away. sodium citrate). • New or worsened eye problems including acute narrow-angle glaucoma. • Do not use in children. It is not known if YUPELRI is safe and effective Acute narrow-angle glaucoma can cause permanent loss of vision if not in children. treated. Symptoms may include: Before using YUPELRI, tell your healthcare provider about all your - Red eyes medical conditions, including if you: - Blurred vision • have eye problems such as glaucoma. YUPELRI may make your - Seeing halos or bright colors around lights glaucoma worse. - Eye pain or discomfort • have prostate or bladder problems, or problems passing urine. YUPELRI - Nausea or vomiting may make these problems worse. • have liver problems. • are allergic to any of the ingredients in YUPELRI, or any other medicines.

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Important Safety Information Common side effects of YUPELRI include: • Cough • Runny nose • Upper respiratory tract infection • Headache • Back pain What are the possible side effects with YUPELRI? (cont’d) Tell your healthcare provider if you get any side effects that bother you or ® • Urinary retention. People who take YUPELRI (revefenacin) inhalation that do not go away. These are not all the possible side effects with YUPELRI. solution may develop new or worse urinary retention. Symptoms of urinary Ask your healthcare provider or pharmacist for more information. Call your retention may include: doctor for medical advice about side effects. You may report side effects to - difficulty urinating FDA at 1-800-FDA-1088. - urinating frequently How should I use YUPELRI? - urination in a weak stream or drips Read the step by step instructions for using YUPELRI at the end of - painful urination this Patient Information Leaflet If you have any of these symptoms, call your healthcare provider right away • YUPELRI is only for use with a nebulizer. before taking another dose. • Do not use YUPELRI more often than prescribed. • Serious allergic reactions. Call your healthcare provider or get • Do not mix YUPELRI with other medicines in your nebulizer. emergency medical care if you get any of the following symptoms of a serious allergic reaction: • Do not use other medicines that contain an anticholinergic for any reason. - rash • Do not stop using YUPELRI, even if you are feeling better, unless your healthcare provider tells you to because your symptoms might get worse. - hives • Call your healthcare provider or get emergency medical care right away if - severe itching - your breathing problems get worse. - swelling of your face, mouth, and tongue - you need to use your rescue inhaler medicine more often than usual. - difficulty breathing or swallowing - your rescue inhaler medicine does not relieve your symptoms. If you have any of these symptoms, stop taking YUPELRI, and call your healthcare provider right away before taking another dose. This summary does not include all the information about YUPELRI and is not meant to take the place of a discussion with your healthcare provider about your treatment.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch,or call 1-800-FDA-1088.

8 9 You’ve got Care Within Reach Here’s what you can expect: • Education on appropriate use of YUPELRI® (revefenacin) inhalation solution and management of your COPD • A free, 7-day trial of YUPELRI shipped to your home • Help with getting a standard jet nebulizer to use at home (if you’re eligible—you don’t have medical insurance, or if your current commercial insurance does not cover the standard jet nebulizer) • Monthly medication refill reminders for up to a year (must opt in) • Optional in-home standard jet nebulizer training from a Respiratory Therapist (RT)

HAVE QUESTIONS ABOUT Reach out. THE CARE WITHIN REACH Monday to Friday 8 AM to 8 PM EST PROGRAM? Call 1-888-YUPELRI (987-3574)

Important Safety Information Tell your healthcare provider about all the medicines you take including prescription and over-the-counter medicines, vitamins, and herbal supplements. YUPELRI and certain other medicines may interact with each other. This may cause serious side effects. Especially tell your healthcare provider if you take: • Other anticholinergics (including tiotropium, ipratropium, aclidinium, umeclidinium, glycopyrrolate) • Atropine Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist each time you get a new medicine. Please see accompanying Full Prescribing Information.

YUPELRI and the YUPELRI logo are registered trademarks of Mylan Specialty L.P. MYLAN and the Mylan logo are registered trademarks of Mylan Inc. THERAVANCE® and the Cross/Star logo are registered trademarks of the Theravance Biopharma group of companies. © 2019 Mylan Specialty L.P. All rights reserved. REV-2019-0169