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Inflammation/Immunology Inflammation/Immunology The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency. www.MedChemExpress.com 1 Inflammation/Immunology Inhibitors & Modulators (+)-Borneol (+)-DHMEQ ((1R,2R,6R)-Dehydroxymethylepoxyquinomicin; (d-Borneol) Cat. No.: HY-N1368A (1R,2R,6R)-DHMEQ) Cat. No.: HY-14645A Bioactivity: (+)-Borneol (d-Borneol) is a natural bicyclic monoterpene used Bioactivity: (+)-DHMEQ is an activator of antioxidant transcription factor for analgesia and anesthesia in traditional Chinese medicine; Nrf2. (+)-DHMEQ is the enantiomer of (-)-DHMEQ. (-)-DHMEQ enhances GABA receptor activity with an EC50 of 248 μM. inhibits NF-kB than its enantiomer (+)-DHMEQ. Purity: 98.0% Purity: 98.02% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 2 mg, 5 mg, 10 mg, 25 mg (-)-Epicatechin (-)-Ketoconazole ((-)-Epicatechol; Epicatechin; epi-Catechin) Cat. No.: HY-N0001 Cat. No.: HY-B0105B Bioactivity: (-)-Epicatechin inhibits cyclooxygenase-1 ( COX-1) with an Bioactivity: (-)-Ketoconazole is one of the enantiomer of Ketoconazole. Ketoconazole is a racemic mixture of two enantiomers, IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the levoketoconazole ((2S,4R)-(−)-ketoconazole) and p65 subunit of NF-κB. dextroketoconazole ((2R,4S)-(+)-ketoconazole). Purity: 99.00% Purity: 99.40% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 10 mg, 50 mg (3R,4S)-Tofacitinib (3S,4R)-Tofacitinib Cat. No.: HY-40354D Cat. No.: HY-40354B Bioactivity: (3R,4S)-Tofacitinib is an enantiomer of Tofacitinib. Bioactivity: (3S,4R)-Tofacitinib is an enantiomer of Tofacitinib. Tofacitinib inhibits JAK3 with IC50 of 1 nM. Tofacitinib inhibits JAK3 with IC50 of 1 nM. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg Size: 5 mg (3S,4S)-Tofacitinib (R)-(-)-Ibuprofen Cat. No.: HY-40354C ((R)-Ibuprofen) Cat. No.: HY-78131B Bioactivity: (3S,4S)-Tofacitinib is the S-enantiomer of Tofacitinib. Bioactivity: (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive Tofacitinib inhibits JAK3 with IC50 of 1 nM. on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects. Purity: >98% Purity: 98.49% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg 200 mg (R)-BPO-27 (R)-Lansoprazole Cat. No.: HY-19778 (Dexlansoprazole) Cat. No.: HY-13662B Bioactivity: (R)-BPO-27 is a potent CFTR inhibitor with an IC50 of 4 nM. Bioactivity: (R)-Lansoprazole is a proton pump inhibitor which prevents the stomach from producing acid. Target: Proton Pump Lansoprazole sodium is sodium salt form of lansoprazole, lansoprazole, a substituted benzimidizole proton pump inhibitor, on pharmacokinetics and metabolism of theophylline has been… Purity: 99.56% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 100 mg, 500 mg 2 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected] (R,R)-Palonosetron Hydrochloride (S)-(+)-Ibuprofen Cat. No.: HY-A0021C ((S)-Ibuprofen) Cat. No.: HY-78131A Bioactivity: (R,R)-Palonosetron Hydrochloride is the active enantiomer of Bioactivity: (S)-(+)-Ibuprofen is the S-enantiomer of Ibuprofen. Ibuprofen Palonosetron. is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively. Purity: 99.61% Purity: 99.97% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 2 mg, 5 mg, 10 mg Size: 1 g, 5 g (S)-(+)-Rolipram (±)-Bisoprolol (hemifumarate) ((+)-Rolipram; (S)-Rolipram) Cat. No.: HY-B0392 (Bisoprolol hemifumarate salt) Cat. No.: HY-B0076 Bioactivity: (S)-(+)-Rolipram is a PDE4-inhibitor and an anti-inflammatory Bioactivity: Bisoprolol is a selective type β1 adrenergic receptor blocker. agent, less potent than its R enantiomer. Purity: 99.85% Purity: 98.41% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 100 mg, 200 mg, 500 mg 1-O-Acetylbritannilactone 13-cis-N-[4-(Ethoxycarbonyl)phenyl]retinamide (Inulicin) Cat. No.: HY-N0896 Cat. No.: HY-112077 Bioactivity: 1-O-Acetylbritannilactone is an active compound isolated from Bioactivity: 13-cis-N-[4-(Ethoxycarbonyl)phenyl]retinamide is a derivative Inula Britannica L. 1-O-Acetylbritannilactone inhibits of Retinoic acid. VEGF-mediated activation of Src and FAK. 1-O-Acetylbritannilactone inhibits LPS-induced PGE2 production and COX-2 expression, and NF-κB activation and… Purity: 99.37% Purity: 98.32% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 5 mg, 10 mg, 50 mg, 100 mg 14-Deoxy-11,12-didehydroandrographolide 1400W Dihydrochloride (14-dehydro Andrographolide; AP10) Cat. No.: HY-N1490 Cat. No.: HY-18731 Bioactivity: 14-Deoxy-11,12-didehydroandrographolide is an analogue of Bioactivity: 1400W dihydrochloride is a potent and selective inhibitor of Andrographolide that can be isolated from A. paniculata. human inducible NO synthase with Ki values of 7 nM. 14-Deoxy-11,12-didehydroandrographolide inhibits NF-κB activation. Purity: 98.0% Purity: 99.66% Clinical Data: Phase 1 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg 5 mg, 10 mg, 50 mg, 100 mg 18β-Glycyrrhetinic acid 24-Norursodeoxycholic acid Cat. No.: HY-N0180 (nor-UDCA) Cat. No.: HY-101737 Bioactivity: 18β-Glycyrrhetinic acid is the major bioactive component of Bioactivity: 24-norursodeoxycholic acid (norUDCA) is a side chain-shortened Glycyrrhizae Radix and possesses anti-ulcerative, C 23 homologue of UDCA and has shown potent anti-cholestatic, anti-inflammatory and antiproliferative properties. anti-inflammatory and anti-fibrotic properties. Purity: 99.63% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 500 mg, 5 g www.MedChemExpress.com 3 25-Hydroxycholesterol 3-Deazaadenosine Cat. No.: HY-113134 Cat. No.: HY-W013332 Bioactivity: 25-Hydroxycholesterol is a metabolite of cholesterol that is Bioactivity: 3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine produced and secreted by macrophages in response to Toll-like hydrolase, with a Ki of 3.9 µM; 3-Deazaadenosine has receptor (TLR) activation. 25-hydroxycholesterol is a potent anti-inflammatory, anti-proliferative and anti- HIV activity. (EC 50≈65 nM) and selective suppressor of IgA production by B cells. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: Size: 1 mg, 5 mg, 10 mg 3-Deazaadenosine hydrochloride 4-O-Methyl honokiol Cat. No.: HY-W013332A Cat. No.: HY-U00450 Bioactivity: 3-Deazaadenosine (hydrochloride) is an inhibitor of Bioactivity: 4-O-Methyl honokiol is a natural neolignan isolated from S-adenosylhomocysteine hydrolase, with a Ki of 3.9 µM; Magnolia officinalis, acts as a PPARγ agonist, and inhibtis 3-Deazaadenosine has anti-inflammatory, anti-proliferative and NF-κB activity, used for cancer and inflammation research. anti- HIV activity. Purity: 98.06% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 25 mg 1 mg, 5 mg, 10 mg 4-Octyl Itaconate 48740 RP Cat. No.: HY-112675 (RP-55778) Cat. No.: HY-100153 Bioactivity: 4-Octyl Itaconate is a cell-permeable Itaconate derivative. Bioactivity: 48740 RP is a platelet-activating factor ( PAF) antagonist. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Purity: 99.64% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 50 mg, 100 mg, 200 mg, 500 mg 5-Aminosalicylic Acid 5-Lipoxygenase-In-1 (Mesalamine; 5-ASA; Mesalazine) Cat. No.: HY-15027 Cat. No.: HY-U00308 Bioactivity: 5-Aminosalicylic acid acts as a specific PPARγ agonist and Bioactivity: 5-Lipoxygenase-In-1 is a 5-Lipoxygenase inhibitor extracted also inhibits p21-activated kinase 1 ( PAK1) and NF-κB. from patent EP 331232 A2, table 4, compound example 4.10. Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 10 g 5Z-7-Oxozeaenol 6-Aminochrysene (FR148083; L783279; LL-Z 1640-2) Cat. No.: HY-12686 (6-Chrysenamine) Cat. No.: HY-108315 Bioactivity: 5Z-7-Oxozeaenol is a natural anti-protozoan compound from Bioactivity: 6-Aminochrysene (6-Aminochrysene) is an aromatic amine used as fungal origin, acting as a potent irreversible and selective a chemotherapeutic agent in the treatment of splenomegaly, inhibitor of TAK1 and VEGF-R2, with IC50s of 8 nM and 52 nM, myeloid leukemia, and breast cancer. respectively. Purity: 99.0% Purity: 95.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10mM x 1mL in DMSO, 25 mg 4 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected] 6-OAU 6-Thioguanine (GTPL5846) Cat.
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