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Inflammation/Immunology

The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

www.MedChemExpress.com 1 Inflammation/Immunology Inhibitors & Modulators

(+)- (+)-DHMEQ ((1R,2R,6R)-Dehydroxymethylepoxyquinomicin; (d-Borneol) Cat. No.: HY-N1368A (1R,2R,6R)-DHMEQ) Cat. No.: HY-14645A

Bioactivity: (+)-Borneol (d-Borneol) is a natural bicyclic monoterpene used Bioactivity: (+)-DHMEQ is an activator of for analgesia and anesthesia in traditional Chinese medicine; Nrf2. (+)-DHMEQ is the enantiomer of (-)-DHMEQ. (-)-DHMEQ

enhances GABA activity with an EC50 of 248 μM. inhibits NF-kB than its enantiomer (+)-DHMEQ.

Purity: 98.0% Purity: 98.02% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 2 mg, 5 mg, 10 mg, 25 mg

(-)-Epicatechin (-)- ((-)-Epicatechol; Epicatechin; epi-) Cat. No.: HY-N0001 Cat. No.: HY-B0105B

Bioactivity: (-)-Epicatechin inhibits -1 ( COX-1) with an Bioactivity: (-)-Ketoconazole is one of the enantiomer of Ketoconazole. Ketoconazole is a racemic mixture of two enantiomers, IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the levoketoconazole ((2S,4R)-(−)-ketoconazole) and p65 subunit of NF-κB. dextroketoconazole ((2R,4S)-(+)-ketoconazole).

Purity: 99.00% Purity: 99.40% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 10 mg, 50 mg

(3R,4S)-Tofacitinib (3S,4R)-Tofacitinib Cat. No.: HY-40354D Cat. No.: HY-40354B

Bioactivity: (3R,4S)-Tofacitinib is an enantiomer of Tofacitinib. Bioactivity: (3S,4R)-Tofacitinib is an enantiomer of Tofacitinib.

Tofacitinib inhibits JAK3 with IC50 of 1 nM. Tofacitinib inhibits JAK3 with IC50 of 1 nM.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg Size: 5 mg

(3S,4S)-Tofacitinib (R)-(-)- Cat. No.: HY-40354C ((R)-Ibuprofen) Cat. No.: HY-78131B

Bioactivity: (3S,4S)-Tofacitinib is the S-enantiomer of Tofacitinib. Bioactivity: (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive

Tofacitinib inhibits JAK3 with IC50 of 1 nM. on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.

Purity: >98% Purity: 98.49% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg 200 mg

(R)-BPO-27 (R)-Lansoprazole Cat. No.: HY-19778 (Dexlansoprazole) Cat. No.: HY-13662B

Bioactivity: (R)-BPO-27 is a potent CFTR inhibitor with an IC50 of 4 nM. Bioactivity: (R)-Lansoprazole is a proton pump inhibitor which prevents the stomach from producing acid. Target: Proton Pump Lansoprazole is sodium salt form of lansoprazole, lansoprazole, a substituted benzimidizole proton pump inhibitor, on and of has been… Purity: 99.56% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 100 mg, 500 mg

2 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

(R,R)-Palonosetron Hydrochloride (S)-(+)-Ibuprofen Cat. No.: HY-A0021C ((S)-Ibuprofen) Cat. No.: HY-78131A

Bioactivity: (R,R)-Palonosetron Hydrochloride is the active enantiomer of Bioactivity: (S)-(+)-Ibuprofen is the S-enantiomer of Ibuprofen. Ibuprofen Palonosetron. is an anti-inflammatory inhibitor targeting COX-1 and COX-2

with IC50 of 13 μM and 370 μM, respectively.

Purity: 99.61% Purity: 99.97% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 2 mg, 5 mg, 10 mg Size: 1 g, 5 g

(S)-(+)-Rolipram (±)- (hemifumarate) ((+)-Rolipram; (S)-Rolipram) Cat. No.: HY-B0392 (Bisoprolol hemifumarate salt) Cat. No.: HY-B0076

Bioactivity: (S)-(+)-Rolipram is a PDE4-inhibitor and an anti-inflammatory Bioactivity: Bisoprolol is a selective type β1 receptor blocker. agent, less potent than its R enantiomer.

Purity: 99.85% Purity: 98.41% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 100 mg, 200 mg, 500 mg

1-O-Acetylbritannilactone 13-cis-N-[4-(Ethoxycarbonyl)phenyl]retinamide (Inulicin) Cat. No.: HY-N0896 Cat. No.: HY-112077

Bioactivity: 1-O-Acetylbritannilactone is an active compound isolated from Bioactivity: 13-cis-N-[4-(Ethoxycarbonyl)phenyl]retinamide is a derivative Inula Britannica L. 1-O-Acetylbritannilactone inhibits of . VEGF-mediated activation of Src and FAK.

1-O-Acetylbritannilactone inhibits LPS-induced PGE2 production and COX-2 expression, and NF-κB activation and… Purity: 99.37% Purity: 98.32% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 5 mg, 10 mg, 50 mg, 100 mg

14-Deoxy-11,12-didehydroandrographolide 1400W Dihydrochloride (14-dehydro Andrographolide; AP10) Cat. No.: HY-N1490 Cat. No.: HY-18731

Bioactivity: 14-Deoxy-11,12-didehydroandrographolide is an analogue of Bioactivity: 1400W dihydrochloride is a potent and selective inhibitor of

Andrographolide that can be isolated from A. paniculata. human inducible NO synthase with Ki values of 7 nM. 14-Deoxy-11,12-didehydroandrographolide inhibits NF-κB activation.

Purity: 98.0% Purity: 99.66% Clinical Data: Phase 1 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg 5 mg, 10 mg, 50 mg, 100 mg

18β-Glycyrrhetinic acid 24-Norursodeoxycholic acid Cat. No.: HY-N0180 (nor-UDCA) Cat. No.: HY-101737

Bioactivity: 18β-Glycyrrhetinic acid is the major bioactive component of Bioactivity: 24-norursodeoxycholic acid (norUDCA) is a side chain-shortened

Glycyrrhizae Radix and possesses anti-ulcerative, C 23 homologue of UDCA and has shown potent anti-cholestatic, anti-inflammatory and antiproliferative properties. anti-inflammatory and anti-fibrotic properties.

Purity: 99.63% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 500 mg, 5 g

www.MedChemExpress.com 3

25-Hydroxycholesterol 3-Deazaadenosine Cat. No.: HY-113134 Cat. No.: HY-W013332

Bioactivity: 25-Hydroxycholesterol is a metabolite of that is Bioactivity: 3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine produced and secreted by in response to Toll-like hydrolase, with a Ki of 3.9 µM; 3-Deazaadenosine has receptor (TLR) activation. 25-hydroxycholesterol is a potent anti-inflammatory, anti-proliferative and anti- HIV activity. (EC 50≈65 nM) and selective suppressor of IgA production by B cells. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: Size: 1 mg, 5 mg, 10 mg

3-Deazaadenosine hydrochloride 4-O-Methyl Cat. No.: HY-W013332A Cat. No.: HY-U00450

Bioactivity: 3-Deazaadenosine (hydrochloride) is an inhibitor of Bioactivity: 4-O-Methyl honokiol is a natural neolignan isolated from

S-adenosylhomocysteine hydrolase, with a Ki of 3.9 µM; Magnolia officinalis, acts as a PPARγ , and inhibtis 3-Deazaadenosine has anti-inflammatory, anti-proliferative and NF-κB activity, used for cancer and inflammation research. anti- HIV activity.

Purity: 98.06% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 25 mg 1 mg, 5 mg, 10 mg

4-Octyl Itaconate 48740 RP Cat. No.: HY-112675 (RP-55778) Cat. No.: HY-100153

Bioactivity: 4-Octyl Itaconate is a cell-permeable Itaconate derivative. Bioactivity: 48740 RP is a platelet-activating factor ( PAF) antagonist. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

Purity: 99.64% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 50 mg, 100 mg, 200 mg, 500 mg

5-Aminosalicylic Acid 5-Lipoxygenase-In-1 (Mesalamine; 5-ASA; ) Cat. No.: HY-15027 Cat. No.: HY-U00308

Bioactivity: 5-Aminosalicylic acid acts as a specific PPARγ agonist and Bioactivity: 5-Lipoxygenase-In-1 is a 5-Lipoxygenase inhibitor extracted also inhibits p21-activated kinase 1 ( PAK1) and NF-κB. from patent EP 331232 A2, table 4, compound example 4.10.

Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 10 g

5Z-7-Oxozeaenol 6-Aminochrysene (FR148083; L783279; LL-Z 1640-2) Cat. No.: HY-12686 (6-Chrysenamine) Cat. No.: HY-108315

Bioactivity: 5Z-7-Oxozeaenol is a natural anti-protozoan compound from Bioactivity: 6-Aminochrysene (6-Aminochrysene) is an aromatic amine used as fungal origin, acting as a potent irreversible and selective a chemotherapeutic agent in the treatment of splenomegaly,

inhibitor of TAK1 and VEGF-R2, with IC50s of 8 nM and 52 nM, myeloid , and . respectively.

Purity: 99.0% Purity: 95.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10mM x 1mL in DMSO, 25 mg

4 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

6-OAU 6-Thioguanine (GTPL5846) Cat. No.: HY-12764 (6-TG; 2-Amino-6-; 2-Amino-6-purinethiol) Cat. No.: HY-13765

Bioactivity: 6-OAU(GTPL5846; 6-n-octylaminouracil) is a surrogate agonist Bioactivity: 6-Thioguanine is an anti-leukemia and immunosuppressant agent, of GPR84; activates human GPR84 in the presence of Gqi5 acts as an inhibitor of SARS and MERS coronavirus papain-like chimera in HEK293 cells with an EC50 of 105 nM in the PI proteases ( PLpros) and also potently inhibits USP2

assay. IC50 value: 105 nM [1] Target: GPR84 agonist in vitro: activity, with IC50s of 25 μM and 40 μM for Plpros and 6-OAU increased [35S]GTPγS incorporated in Sf9 cell membranes… recombinant human USP2, respectively. Purity: 97.53% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 100 mg, 500 mg

6α- 21-hemisuccinate sodium salt 7,4'-Di-O-methylapigenin (Methylprednisolone sodium succinate; …) Cat. No.: HY-B1060 (4',7-Dimethoxy-5-Hydroxyflavone) Cat. No.: HY-N2144

Bioactivity: 6α-Methylprednisolone 21-hemisuccinate sodium salt is a Bioactivity: The compound 7,4'-Di-O-methylapigenin may be partly of slightly longer half-life than that of responsible for the reported activity of C. . It has potential uses in antiinflammatory zeyheri, and may serve as a potential source of lead compounds agents. that can be developed as antifungal phytomedicines.

Purity: 95.04% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 2 mg, 5 mg 10 mg, 50 mg

8-O-Acetyl shanzhiside methyl ester 9-Propenyladenine (Mutagenic Impurity of Tenofovir Cat. No.: HY-N0758 Disoproxil; Tenofovir Impurity 2) Cat. No.: HY-100079

Bioactivity: 8-O-Acetyl shanzhiside methyl ester (ND01) is an iridoid Bioactivity: 9H-Purin-6-amine, 9-(1E)-1-propen-1-yl- is a mutagenic glucoside isolated from the leaves of Lamiophlomis rotata impurity in tenofovir disoproxil fumarate. Tenofovir is an Kudo, a Chinese folk medicinal plant in Xi-zang. 8-O-Acetyl antiretroviral drug known as analogue reverse shanzhiside methyl ester could inhibt NF-κB. transcriptase inhibitors, which block reverse transcriptase, a crucial virus in HIV-1 and HBV. Purity: 98.52% Purity: 96.81% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

A-69412 A-770041 Cat. No.: HY-101945 Cat. No.: HY-11011

Bioactivity: A-69412 is a reversible, specific inhibitor of the hydrophilic Bioactivity: A-770041 is selective and orally active Src-family Lck 5-lipoxygenase ( 5-LO). inhibitor; A-770041 is a 147 nM inhibitor of Lck (1 mM ATP) and is 300-fold selective against Fyn, the other Src family kinase involved in T-.

Purity: >98% Purity: 99.53% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg

A-967079 A2B 1 Cat. No.: HY-108463 Cat. No.: HY-U00321

Bioactivity: A-967079 is a selective TRPA1 receptor antagonist with IC50s Bioactivity: A2B receptor antagonist 1 is a potent A2B receptor of 67 nM and 289 nM at human and rat TRPA1 receptors, antagonist extracted from patent WO 2009157938 A1 EXAMPLE 9B. respectively, and has good penetration into the CNS.

Purity: 98.66% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

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ABBV-744 ABT-702 dihydrochloride Cat. No.: HY-112090 Cat. No.: HY-103161

Bioactivity: ABBV-744 is a highly BDII-selective BET bromodomain Bioactivity: ABT-702 dihydrochloride is a potent adenosine kinase ( AK)

inhibitor, used in the research of inflammatory diseases, inhibitor ( IC50=1.7 nM). cancer, and AIDS.

Purity: 90.0% Purity: 98.03% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg, 50 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

Acebilustat Cat. No.: HY-17625 Cat. No.: HY-B0634

Bioactivity: Acebilustat is a leukotriene A4 hydrolase inhibitor, used for Bioactivity: Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) an oral antiinflammatory drug. analog of .

Purity: 99.48% Purity: 99.80% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 1 g, 5 g 1 mg, 5 mg, 10 mg, 25 mg, 50 mg

Acemetacin Acetaminophen (; 4'-Hydroxyacetanilide; Cat. No.: HY-B0482 4-Acetamidophenol; APAP) Cat. No.: HY-66005

Bioactivity: is a non-steroidal anti-inflammatory drug and a Bioactivity: Acetaminophen (paracetamol) is a selective cyclooxygenase-2 (

ester of that is a cyclooxygenase COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used inhibitor. and drug.

Purity: 99.97% Purity: 99.69% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 5 g, 10 g 1 g, 5 g

ACHP Hydrochloride Cat. No.: HY-13060 (Ro 10-1670) Cat. No.: HY-B0107

Bioactivity: ACHP Hydrochloride is a highly potent and selective IKK-β Bioactivity: Acitretin(Ro 10-1670) is a second-generation, systemic that has been used in the treatment of . inhibitor with an IC50 of 8.5 nM.

Purity: 98.03% Purity: 99.56% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 100 mg, 200 mg, 500 mg

Acitretin sodium Aclidinium (Ro 10-1670 sodium) Cat. No.: HY-B0107A (LAS 34273; LAS-W 330) Cat. No.: HY-14144

Bioactivity: Acitretin sodium(Ro 10-1670) is a second-generation, systemic Bioactivity: (LAS 34273; LAS-W 330) is a long-acting, retinoid that has been used in the treatment of psoriasis. inhaled as a maintenance treatment for chronic obstructive pulmonary disease (COPD).

Purity: >98% Purity: 99.54% Clinical Data: Launched Clinical Data: Launched Size: 100 mg, 200 mg, 500 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

6 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Aconine ACP-105 (Jesaconine) Cat. No.: HY-N0277 Cat. No.: HY-112256

Bioactivity: Aconine inhibits receptor activator of nuclear factor (NF)-κB Bioactivity: ACP-105 is an orally available, selective amd potent (RANKL)-induced NF-κB activation. (SARM), with pEC50s of 9.0 and 9.3 for AR wild type and T877A mutant, respectively.

Purity: 99.23% Purity: 98.37% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Acrivastine ACTH 1-13 (BW825C) Cat. No.: HY-B1510 (Adrenocorticotropic (1-13)) Cat. No.: HY-P1555

Bioactivity: (BW825C) is a short acting 1 Bioactivity: ACTH (1-13) is a 13-aa , with cytoprotective effects in receptor antagonist for the treatment of allergic rhinitis. the model of induced gastric lesions in rats.

Purity: 98.00% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 10 mg, 50 mg, 100 mg

ACTH 11-24 Acumapimod (Adrenocorticotropic Hormone (11-24)) Cat. No.: HY-P1558 Cat. No.: HY-16715

Bioactivity: ACTH (11-24) is a fragment of adrenocorticotrophin, acts as an Bioactivity: Acumapimod (BCT197) is an orally active p38 MAP kinase antagonist of adrenocorticotropic hormone (ACTH) receptor, and inhibitor, with an IC50 of less than 1 μM for p38α. induces release.

Purity: >98% Purity: 99.14% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg

Adapalene sodium salt (CD271) Cat. No.: HY-B0091 (CD 271 sodium salt) Cat. No.: HY-B0091A

Bioactivity: Adapalene(CD-271; Differin), a synthetic retinoid, is a Bioactivity: Adapalene sodium salt(CD 271; Differin), a synthetic retinoid, retinoic acid receptor agonist (RAR). is a Retinoic acid receptor agonist (RAR).

Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 50 mg, 100 mg, 500 mg 50 mg, 100 mg, 500 mg

Adavivint Adelmidrol (SM04690) Cat. No.: HY-109049 Cat. No.: HY-B1026

Bioactivity: Adavivint is a potent and selective inhibitor of canonical Bioactivity: Adelmidrol exerts important anti-inflammatory effects that are

Wnt signaling, with an EC50 of 19.5 nM via a partly dependent on PPARγ. Adelmidrol reduces NF-κB high-throughput TCF/LEF-reporter assay in SW480 colon cancer translocation, and COX-2 expression. cells.

Purity: 98.0% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 100 mg

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Adrenic Acid AE-3763 (cis-7,10,13,16-Docosatetraenoic acid) Cat. No.: HY-W013215 Cat. No.: HY-19406

Bioactivity: Adrenic Acid is an inflammation enhancer in non-alcoholic Bioactivity: AE-3763 is a peptide-based human neutrophil elastase fatty liver disease. inhibitor with an IC50 of 29 nM.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: Size: 250 mg, 500 mg

AG126 AGN 210676 (Tyrphostin AG126) Cat. No.: HY-108330 (Simenepag) Cat. No.: HY-14898

Bioactivity: AG126 is a kinase inhibitor which can prevent the Bioactivity: AGN 210676 is a selective EP2 agonist activation of mitogen-activated protein kinase p42MAPK ( extracted from patent US20070203222A1, Compound example 23, ERK2). has an EC50 of 5 nM.

Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

AH 6809 Ailanthone Cat. No.: HY-10418 (Δ13-Dehydrochaparrinone) Cat. No.: HY-N1943

Bioactivity: AH 6809 is an EP and DP receptor antagonist with nearly equal Bioactivity: Ailanthone (Δ13-Dehydrochaparrinone) is a potent inhibitor of

affinity for the cloned human EP1, EP2, EP3-III, and DP1 both full-length androgen receptor (AR) ( IC50=69nM) receptors. and constitutively active truncated AR splice variants (AR

1-651 IC50=309nM). Purity: 99.47% Purity: 99.71% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg

AKP-11 Albiflorin Cat. No.: HY-104069 Cat. No.: HY-N0037

Bioactivity: AKP-11 is a S1P1 agonist with immunomodulatory activities. Bioactivity: Albiflorin is a major constituent contained in peony root; possesses therapeutic potential for neurodegenerative diseases.

Purity: 98.23% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg

Alcaftadine hemitartrate (R89674) Cat. No.: HY-17039 (Trimeprazine hemitartrate) Cat. No.: HY-12752A

Bioactivity: Alcaftadine(R89674) is a H1 antagonist, Bioactivity: Alimemazine hemitartrate is a derivative that is which is used to prevent eye irritation brought on by allergic generally used as an antipruritic agent and also a conjunctivitis. hemagglutinin ( HA)- receptor antagonist.

Purity: 97.17% Purity: 98.92% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 10 mg, 50 mg, 100 mg

8 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Allantoin alpha-Cyperone (5-Ureidohydantoin) Cat. No.: HY-N0543 (α-Cyperone; (+)-α-Cyperone) Cat. No.: HY-N0710

Bioactivity: Allantoin is a skin conditioning agent that promotes healthy Bioactivity: Alpha-cyperone is associated with the down-regulation of skin, stimulates new and healthy tissue growth. COX-2,IL-6,Nck-2,Cdc42 and Rac1, resulting in reduction of inflammation. which would be highly beneficial for treatment of inflammatory diseases such as AD.

Purity: 98.36% Purity: 99.12% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 5 mg, 10 mg, 25 mg, 50 mg

Alpha- Alvelestat (; Epiestradiol; Epiestrol) Cat. No.: HY-B0141A (AZD9668) Cat. No.: HY-15651

Bioactivity: Alpha-Estradiol is a weak and a 5α-reductase Bioactivity: Alvelestat (AZD9668) is a novel, oral inhibitor of neutrophil inhibitor which is used as a topical in the elastase (NE) with the pIC50 of 7.9 for Human NE. treatment of androgenic alopecia.

Purity: 99.46% Purity: 99.27% Clinical Data: Launched Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 5 mg, 10 mg, 50 mg, 100 mg

AM 103 AM-0902 Cat. No.: HY-14163 Cat. No.: HY-108329

Bioactivity: AM 103 is a potent and selective FLAP inhibitor, with an IC50 Bioactivity: AM-0902 is a potent, selective transient receptor potential A1 ( TRPA1) antagonist with IC s of 71 and 131 nM for rTRPA1 value of 4.2 nM. 50 and hTRPA1, respectively.

Purity: >98% Purity: 99.39% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

AM095 AM095 free acid Cat. No.: HY-16039 Cat. No.: HY-16040

Bioactivity: AM095 is a selective LPA1 receptor antagonist. The IC50 for Bioactivity: AM095 (free acid) is a potent LPA1 receptor antagonist with IC values of 0.98 and 0.73 μM for recombinant human or mouse AM095 antagonism of LPA-induced flux of human or mouse 50

LPA 1-transfected CHO cells is 0.025 and 0.023 μM, LPA1 respectively. respectively. Purity: 98.14% Purity: 99.28% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg 5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg

AM211 AM679 (AM211 free acid) Cat. No.: HY-13213 Cat. No.: HY-14460

Bioactivity: AM211 is a potent, selective and orally bioavailable Bioactivity: AM679 is a potent and selective FLAP inhibitor with IC50s of (PGD2) receptor type 2 (DP2) antagonist, with 2.2 nM/0.6 nM/154 nM for FLAP binding/hLA/hWB respectively.

IC50s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively.

Purity: 99.94% Purity: 99.98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

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AM966 Cat. No.: HY-15277 (BL700) Cat. No.: HY-U00067

Bioactivity: AM966 is a high affinity, selective, oral LPA1-antagonist, Bioactivity: Ambutonium bromide is an antagonist. inhibits LPA-stimulated intracellular calcium release (

IC50=17 nM).

Purity: 98.75% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 50 mg, 100 mg

Amcinonide (CL-34699) Cat. No.: HY-B1197 Cat. No.: HY-U00298

Bioactivity: inhibit NO release from activated microglia with Bioactivity: Amebucort is a synthetic glucocorticoid , may IC50 3.38 nM. Amcinonide has affinity for the glucocorticoid used for the research of inflammatory disorders. receptor.

Purity: >98% Purity: 98.04% Clinical Data: Launched Clinical Data: No Development Reported Size: 100 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

Amfenac Sodium Hydrate AMG 487 Cat. No.: HY-17479A Cat. No.: HY-15319

Bioactivity: Sodium Hydrate is a COX-2 inhibitor. Bioactivity: AMG 487 is an antagonist of the CXCR3, which inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 with

IC50 values of 8.0 and 8.2 nM, respectively.

Purity: 98.65% Purity: 99.65% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg

AMG-009 AMG-47a Cat. No.: HY-19499 Cat. No.: HY-18303

Bioactivity: AMG-009 is a potent antagonist of prostaglandin D2, with IC50 Bioactivity: AMG-47a is a potent inhibitor of Lck and T cell proliferation; of 3 nM and 12 nM for CRTH2 and DP receptors, respectively. exhibits anti-inflammatory activity (ED50 = 11 mg/kg) in the anti-CD3 induced production of IL-2 in mice.

Purity: >98% Purity: 98.78% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg

Aminochlorthenoxazin (ICI 350) Cat. No.: HY-U00152 Cat. No.: HY-B0140

Bioactivity: Aminochlorthenoxazin is an antipyretic and analgesic agent. Bioactivity: Aminophylline is a competitive nonselective phosphodiesterase inhibitor that is used to treat airway obstruction from or COPD. Target: Phosphodiesterase Aminophylline is a compound of the theophylline with in 2:1 ratio. The ethylenediamine improves solubility, and the… Purity: >98% Purity: 99.56% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 100 mg, 500 mg

10 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Amodiaquin dihydrochloride dihydrate (Amodiaquine dihydrochloride dihydrate) Cat. No.: HY-B1322 (CP 65703) Cat. No.: HY-17484

Bioactivity: Amodiaquine dihydrochloride dihydrate is a histamine Bioactivity: Ampiroxicam(CP65703) is a nonselective cyclooxygenase N-methyltransferase inhibitor, used as an antimalarial and inhibitor uesd as anti-inflammatory drug. anti-inflammatory agent. Target: histamine N-methyltransferase Amodiaquine has been shown to be more effective than chloroquine in treating chloroquine-resistant Plasmodium… Purity: 99.98% Purity: 97.36% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 100 mg 10 mg, 50 mg

AN-3485 AN3199 Cat. No.: HY-18325 Cat. No.: HY-19830

Bioactivity: AN-3485 is a benzoxaborole analog, Toll-Like Receptor(TLR) Bioactivity: AN3199 is a PDE4 inhibitor with IC50 of 94.5 nM.

inhibitor with IC50 values ranging from 18 to 580 nM.

Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg

Anagrelide hydrochloride (BL4162A) Cat. No.: HY-B0523A Cat. No.: HY-10863

Bioactivity: Hydrochloride(BL4162A) is a drug used for the Bioactivity: Anandamide is an immune modulator in the central nervous treatment of essential thrombocytosis. system acts via not only receptors ( CB1 and CB2) but also other targets (e.g., GPR18/ GPR55).

Purity: 99.75% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg 10 mg, 50 mg, 100 mg

Anemarsaponin E Cat. No.: HY-N0813 (LY 122512) Cat. No.: HY-17350

Bioactivity: Anemarsaponin E is extracted from Anemarrhena asphodeloides Bioactivity: Anitrazafen is a topically effective antiinflammatory agent Bunge and has anti-inflammatory activity. which displays COX-2 inhibitor activity.

Purity: 99.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 25 mg 5 mg

Ansofaxine hydrochloride Antennapedia Peptide(TFA) (LY03005; LPM570065) Cat. No.: HY-U00096 Cat. No.: HY-P0307A

Bioactivity: Ansofaxine hydrochloride (LY03005; LPM570065) is a triple Bioactivity: Antennapedia Peptide TFA is a 16-mer peptide ; inhibits serotonin, and (RQIKIWFQNRRMKWKK) from Antennapedia preferentially targets

reuptake with IC50 values of 723, 491 and 763 the Class I pathway. nM, respectively.

Purity: >98% Purity: 98.17% Clinical Data: Phase 1 Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg

www.MedChemExpress.com 11

Anti-inflammatory agent 1 Anti-inflammatory agent 2 Cat. No.: HY-U00273 Cat. No.: HY-U00299

Bioactivity: Anti-inflammatory agent 1 is an anti-inflammatory agent Bioactivity: Anti-inflammatory agent 2 can be used to treat and prevent extracted from patent WO 2009003229 A1, example 36. inflammatory diseases extracted from patent WO 2001035936 A2, example 1.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

Antiasthmatic Compound 1 Antipyrine Cat. No.: HY-U00409 (; Phenazon) Cat. No.: HY-B0171

Bioactivity: Antiasthmatic Compound 1 is an antiasthmatic agent, which can Bioactivity: Antipyrine is an analgesic and antipyretic agent. be used to treat allergic asthma.

Purity: >98% Purity: 99.67% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 50 mg, 100 mg

Apigenin (4',5,7-Trihydroxyflavone; Apigenine; Apigenol; C.I. Apremilast Natural Yellow 1) Cat. No.: HY-N1201 (CC-10004) Cat. No.: HY-12085

Bioactivity: is a competitive CYP2C9 inhibitor with a Ki of 2 μM. Bioactivity: Apremilast is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase ( PDE-4) with an IC50 of 74 nM.

Purity: 98.0% Purity: 99.87% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

APY0201 Apyramide Cat. No.: HY-15982 Cat. No.: HY-U00046

Bioactivity: APY0201 is a potent PIKfyve inhibitor, which inhibits the Bioactivity: Apyramide is an anti-inflammatory agent.

conversion of PtdIns3P to PtdIns(3,5)P 2 in the presence of 33 in the presence of [ P]ATP with an IC50 of 5.2 nM. APY0201 also inhibits IL-12/IL-23 production. Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 50 mg, 100 mg

Arachidonic acid Arg-Gly-Asp-Ser (Immunocytophyt; Immunocytophyte; Vevodar) Cat. No.: HY-109590 (RGDS peptide; Fibronectin tetrapeptide) Cat. No.: HY-12290

Bioactivity: is an essential fatty acid and a major Bioactivity: Arg-Gly-Asp-Ser is an binding sequence that inhibits constituent of biomembranes. integrin receptor function, decreases systemic inflammation via inhibition of -triggered activation of leukocytes and attenuates expression of inflammatory , iNOS and MMP-9. Purity: 98.0% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 5 mg, 10 mg, 50 mg

12 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

ARQ 531 AS-35 Cat. No.: HY-112215 Cat. No.: HY-101946

Bioactivity: ARQ 531 is a reversible non-covalent inhibitor of Bruton’s Bioactivity: AS-35 is an orally effective, potent and selective antagonist

Tyrosine Kinase ( BTK), with IC50s of 0.85 nM and 0.39 nM for of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum with IC values of 8 nM, 4 nM and 3 WT-BTK and C481S-BTK, respectively. 50 nM, respectively, and has antiallergic activities.

Purity: 98.54% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

AS1517499 AS2521780 Cat. No.: HY-100614 Cat. No.: HY-12663

Bioactivity: AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM. Bioactivity: AS2521780 is a novel PKCθ selective inhibitor with an IC50 of 0.48 nM.

Purity: 99.17% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Asapiprant Asarylaldehyde (Asaronaldehyde; Asaraldehyde; (S-555739) Cat. No.: HY-16763 2,4,5-trimethoxy-Benzaldehyde) Cat. No.: HY-100580

Bioactivity: Asapiprant is a potent and selective DP1 receptor Bioactivity: Asarylaldehyde is a natural COX-2 inhibitor, which isolated from carrot ( Daucus carota L.) seeds significantly inhibits antagonist with a Ki of 0.44 nM. cyclooxygenase II (COX-2) activity at IC50 value 100 μg/mL.

Purity: 99.67% Purity: 99.68% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 100 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

Asiaticoside Asimadoline (Madecassol) Cat. No.: HY-N0439 (EMD-61753) Cat. No.: HY-107384

Bioactivity: Asiaticoside, a trisaccaride triterpene from Centella asiatica, Bioactivity: Asimadoline is a potent κ receptor agonist with IC50s suppresses TGF-β/Smad signaling through inducing Smad7 and of 5.6 and 1.2 nM for guinea pig and human recombinant κ inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts; , respectively. Asiaticoside shows antioxidant, anti-inflammatory, and anti-ulcer properties. Purity: 98.46% Purity: 99.36% Clinical Data: No Development Reported Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg

Aspirin Aluminum (ASA; Acetylsalicylic Acid) Cat. No.: HY-14654 (Aluminum diacetylsalicylate) Cat. No.: HY-B2175

Bioactivity: Aspirin (acetylsalicylic acid ) is an inhibitor of COX-1 with Bioactivity: Aspirin Aluminum is a novel intermolecular compound which can

an IC50 of 27.75 μM (5 μg/mL); commonly used for the treatment inhibit gastrointestinal mucosal disorders induced by NSAIDs of pain, fever, and inflammation. (non-steroidal anti-inflammatory agents) extracted from patent WO 2010064441 A1.

Purity: 99.0% Purity: 99.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g 100 mg, 1 g

www.MedChemExpress.com 13

Asthma relating compound 1 Astilbin Cat. No.: HY-U00412 Cat. No.: HY-N0509

Bioactivity: Asthma relating compound 1 is an anti-asthmatic agent Bioactivity: Astilbin, a compound, is isolated from the rhizome candidate extracted from patent EP0295656A1. of Smilax glabra. Astilbin enhances NRF2 activation. Astilbin also suppresses TNF-α expression and NF-κB activation.

Purity: >98% Purity: 99.43% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 10 mg, 25 mg, 50 mg, 100 mg

Astragalin (Astragaline; 3-Glucosylkaempferol; Astragaloside VI 3-β-D-glucopyranoside) Cat. No.: HY-N0015 Cat. No.: HY-N6577

Bioactivity: Astragalin (kaempferol-3-O-glucoside) is a flavonoid with Bioactivity: Astragaloside VI could activate EGFR/ERK signalling pathway anti-inflammatory activity and newly found in persimmon leaves to improve wound healing. and green tea seeds.

Purity: 99.64% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 5 mg

Astragalus polysaccharide ATB-346 (Astragalus Polysacharin) Cat. No.: HY-N0937 Cat. No.: HY-15028

Bioactivity: Astragalus polysaccharide, one active component of the Bioactivity: ATB-346 is a novel hydrogen sulphide-releasing derivative of polysaccharides extract of Astragulus, attenuates with markedly reduced toxicity. TNF-α-induced resistance by suppressing miR-721 and activating PPAR-γ and PI3K/Akt in 3T3-L1 adipocytes.

Purity: 98.0% Purity: 98.53% Clinical Data: Phase 4 Clinical Data: Phase 1 Size: 50 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg

Aucubin Auranofin Cat. No.: HY-N0664 (SKF-39162) Cat. No.: HY-B1123

Bioactivity: Aucubin is an iridoid glycoside with a wide range of Bioactivity: Auranofin (SKF-39162) is a thioredoxin reductase ( TrxR) biological activities, including anti-inflammatory, inhibitor with an IC50 of 0.2 μM. anti-microbial, anti-algesic as well as anti-tumor activities.

Purity: 98.50% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 10 mg, 50 mg, 100 mg

Avacopan Avatrombopag (CCX168) Cat. No.: HY-17627 (AKR-501; E5501; AS1670542) Cat. No.: HY-13463

Bioactivity: Avacopan (CCX168) is a potent, selective and orally available Bioactivity: Avatrombopag(AKR-501; AS1670542) is a novel orally-active

complement 5a receptor inhibitor with an IC50 of 0.1 nM. thrombopoietin(TPO) receptor agonist with EC50 of 3.3 nM.

Purity: 99.53% Purity: 98.04% Clinical Data: Phase 3 Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

14 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Avelumab (Anti-Human PD-L1, Human Antibody; MSB 0010718C; AX-024 MSB0010718C) Cat. No.: HY-108730 Cat. No.: HY-107390

Bioactivity: Avelumab is a fully human IgG1 anti-PD-L1 monoclonal antibody Bioactivity: AX-024 is an release inhibitor which can strongly with potential antibody-dependent cell-mediated cytotoxicity. inhibit the production of -6 ( IL-6), -α ( TNFα), -γ ( IFN-γ), IL-10 and IL-17A.

Purity: Purity: 98.0% Clinical Data: Launched Clinical Data: Phase 1 Size: 1 mg, 5 mg, 20 mg Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

AX-024 hydrochloride AX-15836 Cat. No.: HY-107390A Cat. No.: HY-101846

Bioactivity: AX-024 hydrochloride is an cytokine release inhibitor which can Bioactivity: AX-15836 is a potent and selective ERK5 inhibitor with an

strongly inhibit the production of interleukin-6 ( IL-6), IC50 of 8 nM. tumor necrosis factor-α ( TNFα), interferon-γ ( IFN-γ), IL-10 and IL-17A.

Purity: 99.29% Purity: 98.95% Clinical Data: Phase 1 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 2 mg, 5 mg, 10 mg, 25 mg, 50 mg

AZ3451 Cat. No.: HY-112558 Cat. No.: HY-B0170

Bioactivity: AZ3451 is a protease-activated receptor-2 (PAR2) antagonist. Bioactivity: Azatadine is an histamine and inhibitor with IC50 of 6.5 nM and 10 nM, respectively.

Purity: 99.13% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Azatadine dimaleate (Azatadine maleate) Cat. No.: HY-B0170A (BW 57-322) Cat. No.: HY-B0256

Bioactivity: Azatadine dimaleate is an histamine and cholinergic inhibitor Bioactivity: Azathioprine(Azasan, Imuran; BW 57-322) is a drug that with IC50 of 6.5 nM and 10 nM, respectively. suppresses the immune system and is used in organ transplantation and autoimmune disease.

Purity: 99.85% Purity: 99.87% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 1 g, 5 g

AZD 4407 AZD1390 (ZD 4407) Cat. No.: HY-U00217 Cat. No.: HY-109566

Bioactivity: AZD 4407 is a potent 5-lipoxygenase inhibitor. Bioactivity: AZD1390 is an ATM inhibitor.

Purity: >98% Purity: 99.81% Clinical Data: No Development Reported Clinical Data: Phase 1 Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg

www.MedChemExpress.com 15

AZD1981 AZD2098 Cat. No.: HY-15950 Cat. No.: HY-U00064

Bioactivity: AZD1981 is a potent and selective CRTh2 antagonist; displaces Bioactivity: AZD2098 is a potent CC-chemokine receptor 4 ( CCR4) radio-labelled PGD2 from human recombinant DP2 with high inhibitor, used for asthma research. potency (pIC50 = 8.4). IC50 value: Target: GPR44 antagonist in vitro: AZD1981 produced a concentration-dependent displacement of the [3H]PGD2-specific binding with a mean pIC50 of 8.4 ±… Purity: 99.26% Purity: 99.85% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 20 mg

AZD3264 AZD7594 Cat. No.: HY-19362 (AZ13189620) Cat. No.: HY-111453

Bioactivity: AZD3264 is a selective IkB-kinase IKK2 inhibitor. Bioactivity: AZD7594 is a potent selective glucocorticoid

receptor modulator, with an IC50 of 0.9 nM.

Purity: 98.77% Purity: 98.70% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

AZD7624 AZD7986 Cat. No.: HY-103672 (INS 1007) Cat. No.: HY-101056

Bioactivity: AZD7624 is an inhaled p38 inhibitor, with potent Bioactivity: AZD7986 is a Dipeptidyl peptidase 1 ( DPP1) inhibitor with

anti-inflammatory activity. pIC50s of 6.85, 7.6, 7.7, 7.8, and 7.8 in human, mouse, rat, dog and rabbit, respectively.

Purity: >98% Purity: 99.07% Clinical Data: No Development Reported Clinical Data: Phase 1 Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

AZD8797 AZD9056 hydrochloride Cat. No.: HY-13848 Cat. No.: HY-19427A

Bioactivity: AZD8797 is an allosteric non-competitive modulator of the Bioactivity: AZD9056 is a selective orally active inhibitor of P2X7 which

human CX3CR1 receptor; antagonizes CX3CR1 and CXCR2 with Kis plays a significant role in inflammation and pain-causing of 3.9 and 2800 nM, respectively. diseases.

Purity: 98.22% Purity: 98.10% Clinical Data: Launched Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

Azelastine hydrochloride Cat. No.: HY-B0462A Cat. No.: HY-B0462

Bioactivity: Azelastine is a potent, second-generation, selective, Bioactivity: Azelastine HCl is a potent, second-generation, selective, histamine antagonist. histamine antagonist.

Purity: >98% Purity: 99.95% Clinical Data: Launched Clinical Data: Launched Size: 100 mg, 200 mg Size: 10mM x 1mL in DMSO, 100 mg, 200 mg

16 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Baicalin Balicatib (Baicalein 7-O-β-D-glucuronide) Cat. No.: HY-N0197 (AAE581) Cat. No.: HY-15100

Bioactivity: is a flavonoid glycoside isolated from Bioactivity: Balicatib(AAE-581) is a potent and selective inhibitor of baicalensis. Baicalin reduces the expression of NF-κB. cathepsin K; 10-100 fold more potent in cell-based enzyme occupancy assays than against cathepsin B, L, and S.

Purity: 98.01% Purity: 97.23% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg, 1 g, 5 g 5 mg, 10 mg, 50 mg, 100 mg

Balsalazide Balsalazide sodium hydrate Cat. No.: HY-B0667 (Balsalazide disodium dihydrate) Cat. No.: HY-B0667A

Bioactivity: Balsalazide could suppress colitis-associated carcinogenesis Bioactivity: Balsalazide sodium hydrate could suppress colitis-associated through modulation of IL-6/STAT3 pathway. carcinogenesis through modulation of IL-6/STAT3 pathway.

Purity: 99.20% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 10 mg, 50 mg, 100 mg

Bamaluzole Bamirastine Cat. No.: HY-100124 (TAK-427) Cat. No.: HY-101601

Bioactivity: Bamaluzole is a GABA receptor agonist extracted from patent Bioactivity: Bamirastine inhibits ligand binding to recombinant human

WO 2012064642 A1. histamine H 1 receptors ( rhH1R) with an IC50 value of 17.3 nM.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

Baohuoside I BAR502 (Icariin-II; Icariside-II) Cat. No.: HY-N0011 Cat. No.: HY-101273

Bioactivity: Baohuoside I, a flavonoid isolated from Epimedium koreanum Bioactivity: BAR502 is a dual FXR and GPBAR1 agonist with IC50 values of Nakai, acts as an inhibitor of CXCR4, downregulates CXCR4 2 μM and 0.4 μM, respectively. expression, induces and shows anti-tumor activity.

Purity: 98.96% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

Baricitinib Baricitinib (INCB028050; LY3009104) Cat. No.: HY-15315 (INCB028050; LY3009104) Cat. No.: HY-15315A

Bioactivity: Baricitinib is a selective and orally bioavailable JAK1 and Bioactivity: Baricitinib phosphate is a selective orally bioavailable

JAK2 inhibitor with IC50s of 5.9 nM and 5.7 nM, respectively. JAK1/ JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, respectively.

Purity: 99.70% Purity: 99.49% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg 5 mg, 10 mg, 50 mg, 100 mg

www.MedChemExpress.com 17

Batefenterol Bavachinin (GSK961081; TD-5959) Cat. No.: HY-12980 (7-O-Methylbavachin; Bavachinin A) Cat. No.: HY-N0234

Bioactivity: Batefenterol (GSK961081;TD-5959) is a novel muscarinic Bioactivity: Bavachinin(7-O-Methylbavachin) is a natural compound isolated from the Chinese herb Fructus Psoraleae;has potent receptor antagonist and β2-adrenoceptor agonist; displays high affinity for hM2, hM3 muscarinic and hβ -adrenoceptor anti-angiogenic activity. IC50 value: Target: in vitro: 2 Isobavachalcone significantly inhibits both oligomerization with K values of 1.4, 1.3 and 3.7 nM, respectively. i and fibrillization of Aβ42, whereas bavachinin inhibits… Purity: 98.30% Purity: 99.62% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg

BAY 11-7082 BAY 41-2272 (BAY 11-7821) Cat. No.: HY-13453 Cat. No.: HY-12376

Bioactivity: BAY 11-7082 is a NF-κB inhibitor which decreases NF-κB by Bioactivity: BAY 41-2272 is a soluble guanylate cyclases (sGC) activator. inhibiting TNF-α-induced phosphorylation of IκB-α. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 with

IC50s of 0.19 μM and 0.96 μM, respectively.

Purity: 99.42% Purity: 99.93% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

BAY 61-3606 BAY 61-3606 dihydrochloride Cat. No.: HY-76474 (BAY 61-3606) Cat. No.: HY-14985

Bioactivity: BAY 61-3606 is a potent, ATP-competitive, reversible, and Bioactivity: BAY 61-3606 (dihydrochloride) is a potent, ATP-competitive, highly selective inhibitor of Syk tyrosine kinase activity reversible, and highly selective inhibitor of Syk tyrosine

(Ki= 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, kinase ( IC50=10 nM) with no inhibitory effect on Btk, Fyn, Lyn, and Src. Itk, Lyn, and Src.

Purity: >98% Purity: 97.22% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg

Bay 65-1942 free base Bay 65-1942 hydrochloride Cat. No.: HY-50949 Cat. No.: HY-50948

Bioactivity: Bay 65-1942 free base is an ATP-competitive and selective IKKβ Bioactivity: Bay 65-1942 hydrochloride is an ATP-competitive and selective inhibitor. IKKβ inhibitor.

Purity: >98% Purity: 99.05% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg

Bay 65-1942 R form BCX 1470 Cat. No.: HY-50949A ( inhibitor) Cat. No.: HY-50874

Bioactivity: Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bioactivity: BCX 1470 inhibits the esterolytic activity of factor D Bay 65-1942 is an ATP-competitive and selective IKKβ (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, inhibitor. respectively, than that of trypsin.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg Size: 5 mg, 10 mg

18 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

BCX 1470 methanesulfonate (BCX 1470) Cat. No.: HY-50875 (Beclomethasone) Cat. No.: HY-B1540

Bioactivity: BCX 1470 inhibits the esterolytic activity of factor D Bioactivity: Beclometasone (Beclomethasone) is a prototype glucocorticoid (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, receptor agonist. respectively, than that of trypsin.

Purity: 99.43% Purity: 92.92% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 25 mg, 50 mg, 100 mg

Beclometasone dipropionate hydrochloride Cat. No.: HY-13571A Cat. No.: HY-30235A

Bioactivity: Beclometasone dipropionate is a potent glucocorticoid agonist; Bioactivity: Benzydamine Hcl is a locally-acting nonsteroidal it is a prodrug of the free form, beclometasone. IC50 Value: anti-inflammatory drug with local anaesthetic and analgesic 0.2 nM (Inhibiting thymidine incorporation) [1] Target: properties; selectively binds to prostaglandin synthetase and in vitro: Cortisol and beclomethasone has notable in vitro antibacterial activity. dipropionate were more potent than in inhibiting… Purity: 99.92% Purity: 98.79% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 250 mg 100 mg

Beperidium iodide Beslilate (SX 810) Cat. No.: HY-100152 Cat. No.: HY-A0015

Bioactivity: Beperidium iodide shows a competitive antagonistic effect Bioactivity: Bepotastine Beslilate (Bepreve) is a histamine H1 receptor against with a pA2 of 7.93. anatagonist.

Purity: >98% Purity: 99.36% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg

BET-IN-1 Cat. No.: HY-19760 Cat. No.: HY-13570

Bioactivity: BET-IN-1 is a bromodomain inhibitor extracted from patent Bioactivity: Betamethasone is a glucocorticoid with WO/2013024104A1, compound example 2, has a plC50 in the range anti-inflammatory and immunosuppressive properties. Target: 6.0 - 7.0. Glucocorticoid Receptor Betamethasone is a potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. Unlike other drugs with these… Purity: 99.01% Purity: 99.24% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 100 mg, 500 mg

Betamethasone 17-benzoate Betamethasone dipropionate Cat. No.: HY-U00161 (Betamethasone 17,21-dipropionate) Cat. No.: HY-13571

Bioactivity: Betamethasone 17-benzoate is a representative steroid, which Bioactivity: Betamethasone dipropionate is a glucocorticoid steroid with can be used in the treatment of recurrent aphothous ulcers anti-inflammatory and immunosuppressive abilities. (RAU).

Purity: >98% Purity: 99.12% Clinical Data: Launched Clinical Data: Launched Size: 5 mg Size: 10mM x 1mL in DMSO, 250 mg, 1 g

www.MedChemExpress.com 19

Betamethasone hydrochloride Betamethasone-17-butyrate-21-propionate Cat. No.: HY-13570A Cat. No.: HY-B0775

Bioactivity: Betamethasone (hydrochloride) is a glucocorticoid steroid with Bioactivity: Betamethasone-17-butyrate-21-propionate is a topical anti-inflammatory and immunosuppressive properties. corticosteroid with potential in the treatment of inflammatory skin diseases.

Purity: >98% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 100 mg, 500 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

Betulinic acid Bevenopran (Lupatic acid; Betulic acid) Cat. No.: HY-10529 (CB-5945; ADL-5945) Cat. No.: HY-100122

Bioactivity: is a natural pentacyclic triterpenoid, acts as Bioactivity: Bevenopran is a peripheral μ-opioid receptor antagonist.

a eukaryotic topoisomerase I inhibitor, with an IC50 of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties.

Purity: 98.58% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg 100 mg, 200 mg, 500 mg

BIBR 1087 SE (Desethyl Etexilate) Cat. No.: HY-W004360 Cat. No.: HY-14447

Bioactivity: BIBR 1087 SE is an intermediate metabolite of dabigatran Bioactivity: Bilastine is a selective histamine H1 receptor antagonist used etexilate. for treatment of allergic rhinoconjunctivitis and urticaria.

Purity: 96.86% Purity: 99.95% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg 10 mg, 50 mg, 100 mg

Bimosiamose Bindarit (TBC 1269) Cat. No.: HY-106139 (AF2838) Cat. No.: HY-B0498

Bioactivity: Bimosiamose is a pan- selectin antagonist, inhibits E-, P-, Bioactivity: Bindarit(AF-2838), a CCL2, CCL7 and CCL8 inhibitor, is an anti-inflammatory agent. and L-selectin with IC50s of 88 μM, 20 μM, and 86 μM, respectively, and can be used in the research of inflammatory disease.

Purity: >98% Purity: 99.83% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg

BMS-066 BMS-1 Cat. No.: HY-18710 (PD-1/PD-L1 inhibitor 1) Cat. No.: HY-19991

Bioactivity: BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor, with IC50s of 9 Bioactivity: BMS-1 is an inhibitor of the PD-1/PD-L1 protein/protein nM and 72 nM, respectively. interaction.

Purity: >98% Purity: 99.85% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

20 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

BMS-1166 BMS-509744 (PD-1/PD-L1-IN1) Cat. No.: HY-102011 Cat. No.: HY-11092

Bioactivity: BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an Bioactivity: BMS-509744 Itk IC50 19 nM IC50 of 1.4 nM.

Purity: >98% Purity: 98.02% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg

BMS-582949 hydrochloride BMS-935177 Cat. No.: HY-14305A Cat. No.: HY-101793

Bioactivity: BMS-582949 hydrochloride is a novel highly selective p38α MAPK Bioactivity: BMS-935177 is a potent and selective reversible inhibitor of

inhibitor, inhibits p38α with IC50 of 13 nM. Bruton’s tyrosine kinase ( Btk) with an IC50 of 3 nM.

Purity: 98.83% Purity: 99.05% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

BMS-986120 BMS-986142 Cat. No.: HY-19837 Cat. No.: HY-101856

Bioactivity: BMS-986120 is an antagonist of the Platelet Protease-Activated Bioactivity: BMS-986142 is a potent and highly selective reversible

Receptor-4 ( PAR4), with IC50s of 9.5, 2.1 nM in human and inhibitor of Bruton's tyrosine kinase ( BTK) with an IC 50 monkey blood, respectively. of 0.5 nM.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 250 mg, 500 mg Size: 250 mg, 500 mg

BMY-25271 BPO-27 racemate Cat. No.: HY-100191 Cat. No.: HY-19778A

Bioactivity: BMY-25271 is a antagonist. Bioactivity: BPO-27 racemate is a potent CFTR inhibitor with an IC50 of 8 nM.

Purity: >98% Purity: 98.67% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

Brequinar sodium hydrate (DUP785; NSC 368390) Cat. No.: HY-108325 (Bromfenac monosodium salt sesquihydrate) Cat. No.: HY-B1888B

Bioactivity: Brequinar is a potent inhibitor of dihydroorotate Bioactivity: Bromfenac (sodium hydrate) is a nonsteroidal anti-inflammatory dehydrogenase, with potent activities against a broad drug (NSAID), which has anti-inflammatory activity. spectrum of viruses.

Purity: 99.57% Purity: 99.70% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 10 mg, 50 mg, 100 mg, 200 mg

www.MedChemExpress.com 21

Bromisoval maleate (Bromovalerylurea) Cat. No.: HY-B2113 Cat. No.: HY-B0480

Bioactivity: has anti-inflammatory effects and has been used as Bioactivity: Brompheniramine maleate is a histamine H1 receptors an old sedative and hypnotic. antagonist.

Purity: 99.94% Purity: 99.95% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g 50 mg, 100 mg

Bronchospasmolytic agent 1 BT-11 Cat. No.: HY-U00405 Cat. No.: HY-102013

Bioactivity: Bronchospasmolytic agent 1, a synthetic flutropium bromide Bioactivity: BT-11 is an orally available LANCL2 binding compound for compound, acts as a bronchospasmolytic agent. treating inflammatory bowel disease.

Purity: >98% Purity: 98.60% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

BTK IN-1 Btk inhibitor 2 Cat. No.: HY-101941 Cat. No.: HY-101766

Bioactivity: BTK IN-1 is a potent BTK inhibitor, with an IC50 of <100 Bioactivity: Btk inhibitor 2 is a Bruton's tyrosine kinase ( BTK) nM. inhibitor extracted from patent US 20170224688 A1.

Purity: 98.88% Purity: 98.93% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

BTM-1086 Bucloxic acid Cat. No.: HY-U00406 (804CB; Bucloxonic acid; Esfar) Cat. No.: HY-101581

Bioactivity: BTM-1086 is a potent anti-ulcer and gastric secretory Bioactivity: Bucloxic acid is an anti-inflammatory pyrrazole derivative. inhibiting agent. Bucloxic acid can be used in the treatment of chronic glomerular nephropathies.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

Bufexamac BVT 2733 (Bufexamic acid) Cat. No.: HY-B0494 Cat. No.: HY-18054

Bioactivity: is a class IIB histone deacetylases (HDAC6 and Bioactivity: BVT 2733 is a new, small molecule, non-steroidal, HDAC10) inhibitor used as an anti-inflammatory agent. isoform-selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1).

Purity: 98.0% Purity: 98.00% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 5 mg, 10 mg, 50 mg, 100 mg

22 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

BW-A 78U BX471 Cat. No.: HY-100118 (ZK-811752) Cat. No.: HY-12080

Bioactivity: BW-A 78U is a PDE4 inhibitor with an IC50 of 3 μM. Bioactivity: BX471 is a potent and selective non-peptide CCR1 antagonist with a Ki of 1 nM, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.

Purity: >98% Purity: 95.64% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg

BX471 hydrochloride Bz 423 (ZK-811752 (hydrochloride)) Cat. No.: HY-12080A (BZ48) Cat. No.: HY-13108

Bioactivity: BX471 hydrochloride is a potent, selective non-peptide CCR1 Bioactivity: Bz 423 is a pro-apoptotic 1,4- with therapeutic properties in murine models of lupus demonstrating selectivity antagonist with Ki of 1 nM for human CCR1, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. for autoreactive lymphocytes, and activates Bax and Bak.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mg, 50 mg Size: 1 mg

C 87 C-176 Cat. No.: HY-100735 (STING inhibitor 1) Cat. No.: HY-112906

Bioactivity: C87 is a novel small-molecule TNFα inhibitor; potently Bioactivity: C-176 is a strong and covalent mouse STING inhibitor.

inhibits TNFα-induced cytotoxicity with an IC50 of 8.73 μM.

Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg c-FMS inhibitor C29 Cat. No.: HY-13075 Cat. No.: HY-100461

Bioactivity: c-FMS inhibitor is a novel c-Fms kinase inhibitor with a Bioactivity: C29 is a Toll-like receptor 2 (TLR2) inhibitor. potential as anti-inflammatory agent and antirheumatic agent. IC50 value: Target: c-Fms

Purity: 99.39% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

C3a 70-77 CaCCinh-A01 (Complement 3a (70-77)) Cat. No.: HY-P1505 Cat. No.: HY-100611

Bioactivity: C3a (70-77) is an octapeptide corresponding to the COOH Bioactivity: CaCCinh-A01 is an inhibitor of both TMEM16A and

terminus of C3a, exhibits the specificity and 1 to 2% biologic calcium-activated ( CaCC) with IC50s of activities of C3a. 2.1 and 10 μM, respectively.

Purity: >98% Purity: 99.60% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

www.MedChemExpress.com 23

Caffeic acid phenethyl ester Cat. No.: HY-N0172 Cat. No.: HY-N0274

Bioactivity: Caffeic acid is an inhibitor of both TRPV1 and Bioactivity: Caffeic acid phenethyl ester is a NF-κB inhibitor. 5-Lipoxygenase ( 5-LO).

Purity: 98.80% Purity: 99.67% Clinical Data: Phase 4 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 5 g 5 mg, 70 mg, 100 mg

Calcipotriol Impurity C (MC 903; Calcipotriene) Cat. No.: HY-10001 Cat. No.: HY-75035

Bioactivity: Calcipotriol is a synthetic VitD 3 analogue with a high Bioactivity: Calcipotriol Impurity C is the impurity of Calcipotriol, affinity for the receptor. Calcipotriol is a ligand of VDR-like receptors. Target: VDR

Purity: 99.76% Purity: 99.20% Clinical Data: Launched Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 500 mg

Calcipotriol monohydrate Calf thymus DNA Cat. No.: HY-10001A (DNA from calf thymus, Thymonucleic acid) Cat. No.: HY-109517

Bioactivity: Calcipotriol monohydrate is a synthetic VitD3 analogue with a Bioactivity: Calf thymus DNA is high quality double-stranded template DNA high affinity for the vitamin D receptor. isolated from the thymus of male and female calves.

Purity: 99.75% Purity: Clinical Data: Launched Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg, 100 mg Size: 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

CAM-IN-1 CaMKII-IN-1 Cat. No.: HY-U00003 Cat. No.: HY-18271

Bioactivity: CAM-IN-1 is a potent and selective inhibitor of E-selectin and Bioactivity: CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM; significantly high selectivity against ICAM-1 with IC50 values of 7 and 5 nM, respectively. CaMKIV, MLCK, p38a, Akt1, and PKC.

Purity: 99.73% Purity: 98.09% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 50 mg, 100 mg

Camobucol (AGIX 4207) Cat. No.: HY-14916 (E 161g; all-trans-Canthaxanthin) Cat. No.: HY-B1960

Bioactivity: Camobucol is an orally active, phenolic antioxidant and Bioactivity: Canthaxanthin is a red-orange with various anti-inflammatory compound with antirheumatic properties. biological activities, such as antioxidant, antitumor properties.

Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 5 mg, 10 mg, 50 mg, 100 mg

24 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Carbasalate calcium Carbetapentane citrate Cat. No.: HY-17476 (Pentoxyverine citrate) Cat. No.: HY-B1055

Bioactivity: is an anti-inflammatory, antipyretic, and Bioactivity: Carbetapentane citrate is a selective inhibitor of the cough, analgesic agent. with mild -like effect and local anesthesia effect.

Purity: 98.0% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg 100 mg, 500 mg

Cariporide Carnosic acid (HOE-642) Cat. No.: HY-19693 Cat. No.: HY-N0644

Bioactivity: Cariporide (HOE-642) is a selective Na+/H+ exchange Bioactivity: Carnosic acid has demonstrated inhibition of oxidative stress inhibitor. and inflammation, suppression of cell proliferation, and antibacterial activity.

Purity: 98.57% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg

Carprofen Carsalam Cat. No.: HY-B1227 (Carbonylsalicylamide; 2H-1,3-Benzoxazine-2,4(3H)-dione) Cat. No.: HY-B1047

Bioactivity: is a nonsteroid anti-inflammatory agent, acts as a Bioactivity: Carsalam is a nonsteroidal anti-inflammatory drug.

multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.

Purity: 99.76% Purity: 99.72% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 100 mg

Cathepsin Inhibitor 2 CAY10595 Cat. No.: HY-U00377 Cat. No.: HY-118180

Bioactivity: Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor Bioactivity: CAY10595 is a potent CRTH2/DP2 receptor antagonist that binds

extracted from patent WO2009123623A1, has a Ki of <20 nM. to the human receptor with a Ki of 10 nM.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 250 mg, 500 mg

CAY10602 CAY10650 Cat. No.: HY-104073 Cat. No.: HY-10801

Bioactivity: CAY10602 is a SIRT1 activator. Bioactivity: CAY10650 is a highly potent cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC 50 value of 12 nM.

Purity: 98.56% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 50 mg

www.MedChemExpress.com 25

CB1 antagonist 1 CC-930 Cat. No.: HY-U00397 (Tanzisertib) Cat. No.: HY-15495

Bioactivity: CB1 antagonist 1 is an antagonist of CB1 receptor, used in Bioactivity: CC-930 is a potent JNK1/ JNK2/ JNK3 inhibitor with IC50 the research of metabolic syndrome and obesity, values of 61/7/6 nM, respectively, and used for the treatment neuroinflammatory disorders, cognitive disorders and of fibrotic and infammatory indications. psychosis, gastrointestinal disorders, and cardiovascular conditions. Purity: >98% Purity: 99.98% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

CCCP (Carbonyl cyanide 3-chlorophenylhydrazone; Carbonyl CCG-203971 Cyanide m-Chlorophenylhydrazone) Cat. No.: HY-100941 Cat. No.: HY-108361

Bioactivity: CCCP is an oxidative phosphorylation uncoupler. Bioactivity: CCG-203971 is a second-generation RhoA/myocardin-related transcription factor A ( MRTF-A) inhibitor. CCG-203971 potently targets RhoA/C-activated serum response element

(SRE)-luciferase (IC 50=6.2 μM).

Purity: 99.83% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg 10 mg, 25 mg, 50 mg, 100 mg

CCR1 antagonist 1 CCR2-RA-[R] Cat. No.: HY-U00350 Cat. No.: HY-50081

Bioactivity: CCR1 antagonist 1 is an antagonist of CCR1 receptor, with Bioactivity: CCR2-RA-[R] is an allosteric antagonist of the C-C chemokine

anti-inflammatory activity. receptor type 2 (CCR2) with an IC50 of 103 nM.

Purity: >98% Purity: 99.36% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

CCR3 antagonist 1 CDK8-IN-3 Cat. No.: HY-U00331 Cat. No.: HY-111463

Bioactivity: CCR3 antagonist 1 is a potent antagonist of CCR3, used for Bioactivity: CDK8-IN-3 is an inhibitor of CDK8 extracted from patent the research of immunologic and inflammatory diseases. WO2016041618A1, compound example 1.7.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 250 mg, 500 mg

Cecropin A Celastrol Cat. No.: HY-P1539 (Tripterin) Cat. No.: HY-13067

Bioactivity: Cecropin A is a linear 37-residue antimicrobial polypeptide, Bioactivity: Celastrol is a which potently and with anticancer and anti-inflammatory activity. preferentially inhibits the chymotrypsin-like activity of a

purified 20S proteasome with IC50 of 2.5 μM.

Purity: >98% Purity: 99.90% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg

26 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Celecoxib Cenerimod (Celebra; Celebrex; SC 58635) Cat. No.: HY-14398 (ACT-334441) Cat. No.: HY-17606

Bioactivity: is a selective COX-2 inhibitor with an IC50 of 40 Bioactivity: Cenerimod (ACT-334441) is a potent and orally available nM. sphingosine 1-phosphate 1 receptor ( S1P1) agonist extracted from patent WO 2016184939 A1 and WO 2011007324 A1, example 1,

with an EC50 of 2.7 nM.

Purity: 99.50% Purity: 98.43% Clinical Data: Launched Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 1 g 2 mg, 5 mg, 10 mg, 50 mg, 100 mg

Cenicriviroc Mesylate Cephalosporin C salt (TAK-652 Mesylate; TBR-652 Mesylate) Cat. No.: HY-14882A Cat. No.: HY-B1299A

Bioactivity: Cenicriviroc is a dual CCR2/CCR5 antagonist, also inhibits Bioactivity: Cephalosporin C zinc salt is a potent inhibitor of SAMHD1

both HIV-1 and HIV-2, and displays potent anti-inflammatory with an IC50 of 1.1 μM. and antiinfective activity.

Purity: 98.23% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg 10 mg, 50 mg, 100 mg

Cetirizine dihydrochloride Cat. No.: HY-17042 (P071) Cat. No.: HY-17042A

Bioactivity: Cetirizine, a second-generation , is a major Bioactivity: Cetirizine 2Hcl, a second-generation antihistamine, is a major metabolite of , and a racemic selective H1 receptor metabolite of hydroxyzine, and a racemic selective H1 receptor used in the treatment of allergies, hay fever, inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria. IC50 value: Target: Histamine H1 angioedema, and urticaria. IC50 value: Target: Histamine H1 receptor Cetirizine crosses the blood-brain barrier only… receptor Cetirizine crosses the blood-brain barrier only… Purity: >98% Purity: 99.17% Clinical Data: Launched Clinical Data: Launched Size: 100 mg, 200 mg, 500 mg Size: 10mM x 1mL in DMSO, 100 mg, 200 mg, 500 mg cFMS-IN-2 cGAMP Cat. No.: HY-18787 (Cyclic AMP-GMP; Cyclic GMP-AMP) Cat. No.: HY-12512

Bioactivity: cFMS-IN-2 is a FMS kinase inhibitor with an IC50 of 0.024 Bioactivity: cGAMP(Cyclic GMP-AMP) is an endogenous second messenger in μM. metazoans and triggers interferon production in response to cytosolic DNA; STING ligand. Target: in vitro: cGAMP induced IFNβ RNA robustly even at concentrations as low as 10 nM. cGAMP was much more potent than c-di-GMP in inducing IFNβ… Purity: 99.05% Purity: 98.56% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 500u g, 1 mg

CGI-1746 CGS 15435 Cat. No.: HY-11999 Cat. No.: HY-100283

Bioactivity: CGI-1746 is a potent and highly selective inhibitor of Bioactivity: CGS 15435, a potent ( TxA2) synthetase inhibitor the Btk with IC50 of 1.9 nM. with an IC50 of 1 nM, has a selectivity for Tx synthetase

100000-fold greater than that for cyclooxygenase, PGI 2 synthetase and lipoxygenase . Purity: 95.03% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 5 mg, 10 mg, 50 mg, 100 mg

www.MedChemExpress.com 27

CH-223191 Chebulagic acid Cat. No.: HY-12684 Cat. No.: HY-N1996

Bioactivity: CH-223191 is a potent and specific antagonist of aryl Bioactivity: Chebulagic acid is a COX-LOX dual inhibitor isolated from the hydrocarbon receptor (AhR). CH-223191 blocks the binding of fruits of Terminalia chebula Retz, on angiogenesis.

TCDD to AhR with an IC50 of 0.03 µM.

Purity: 98.16% Purity: 98.19% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg 2 mg, 5 mg, 10 mg, 25 mg

Chelerythrine Chloride hydrochloride Cat. No.: HY-12048 Cat. No.: HY-112067A

Bioactivity: Chloride is a potent, cell-permeable inhibitor Bioactivity: Chlorcyclizine hydrochloride is a histamine H1 antagonist.

of protein kinase C, with an IC50 of 660 nM, competitive with respect to the phosphate acceptor and non-competitive with respect to ATP.

Purity: 98.0% Purity: 99.90% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 100 mg, 200 mg, 500 mg

Chlorogenic acid Chloroquine diphosphate (3-O-Caffeoylquinic acid; Heriguard; NSC-407296) Cat. No.: HY-N0055 Cat. No.: HY-17589

Bioactivity: Chlorogenic acid is a major phenolic compound in coffee and Bioactivity: Chloroquine (diphosphate) is an antimalarial and tea. It plays several important and therapeutic roles such as anti-inflammatory drug widely used to treat malaria and antioxidant activity, antibacterial, hepatoprotective, rheumatoid arthritis. Chloroquine is an inhibitor of cardioprotective, anti-inflammatory, antipyretic, autophagy and toll-like receptors (TLRs). neuroprotective, anti-obesity, antiviral, anti-microbial,… Purity: 99.29% Purity: 99.94% Clinical Data: Phase 3 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 500 mg 100 mg

Chlorpheniramine maleate Chlorthenoxazine ( maleate) Cat. No.: HY-B0286A (Chlorethylbenzmethoxazone) Cat. No.: HY-101751

Bioactivity: Chlorpheniramine maleate is an histamine H1 receptor Bioactivity: Chlorthenoxazine is a nonsteroidal anti-inflammatory drug. antagonist with IC50 of 12 nM.

Purity: 99.91% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 1 g, 5 g

Chlorzoxazone Cholera toxin Cat. No.: HY-B1462 (choleragen) Cat. No.: HY-P1446

Bioactivity: is a centrally acting used to Bioactivity: Cholera toxin is a multifunctional protein produced by Vibrio treat muscle spasm and the resulting pain or discomfort. It cholera. Cholera toxin is not just another enterotoxin that acts on the spinal cord by depressing reflexes.Chlorzoxazone causes cholera but also able to influence the immune system in is currently being used as a marker substrate in vitro/vivo many ways. Sequence: N/A. studies to quantify cytochrome P450 2E1 (CYP2E1) activity in… Purity: 99.72% Purity: 90.80% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 1 mg 5 g

28 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Cholesteryl palmitate Cat. No.: HY-W010708 (Chondroitin polysulfate) Cat. No.: HY-B2162

Bioactivity: Cholesteryl palmitate is a useful prognostic biomarker for Bioactivity: Chondroitin sulfate, one of five classes of chronic interstitial pneumonia (CIP). , has been widely used in the treatment of . Chondroitin sulfate reduces inflammation mediators and the apoptotic process and is able to reduce protein production of inflammatory cytokines, iNOS and MMPs Purity: >98% Purity: 95.40% Clinical Data: No Development Reported Clinical Data: Launched Size: Size: 250 mg, 1 g

Chymase-IN-1 Chymase-IN-2 Cat. No.: HY-100269 Cat. No.: HY-U00282

Bioactivity: Chymase-IN-1 is a potent, selective, orally active, nonpeptide Bioactivity: Chymase-IN-2 is a chymase modulator which is useful in the

inhibitor of human chymase with an IC50 of 29 nM. treatment of inflammatory and mediated disorders.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

CI-1044 CI-949 (PD-189659) Cat. No.: HY-100246 Cat. No.: HY-U00364

Bioactivity: CI-1044 is an orally active PDE4 inhibitor with IC50s of Bioactivity: CI-949 is an allergic mediator release inhibitor, which inhibits histamine, leukotriene C /D (LTC /LTD ), and 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and 4 4 4 4

PDE4D3, respectively. thromboxane B2 (TXB2) release with IC50s of 11.4 μM, 0.5 μM and 0.1 μM, respectively. Purity: 98.00% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 1 mg, 5 mg, 10 mg

Ciclesonide CID-1067700 (RPR251526) Cat. No.: HY-B0625 Cat. No.: HY-13452

Bioactivity: (RPR251526) is a glucocorticoid used to treat Bioactivity: CID-1067700 is a pan GTPase inhibitor, and competitively obstructive airway diseases. inhibits Ras-related in brain 7 ( Rab7) with a Ki of 13 nM.

Purity: 98.95% Purity: 98.86% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 5 mg, 10 mg

CID-2858522 Cilomilast Cat. No.: HY-15530 (SB-207499) Cat. No.: HY-10790

Bioactivity: CID-2858522 is a highly potent and selective antigen Bioactivity: Cilomilast(SB 207499; Ariflo) is a potent PDE4 inhibitor with

receptor-mediated NF-κB activation inhibitor with an IC50 of IC50 of about 110 nM, has anti-inflammatory activity and low 70 nM. central nervous system activity.

Purity: 96.57% Purity: 98.81% Clinical Data: No Development Reported Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 5 mg, 10 mg, 50 mg, 100 mg

www.MedChemExpress.com 29

Cimetropium Bromide Cimifugin Cat. No.: HY-U00106 (Cimitin) Cat. No.: HY-N0634

Bioactivity: is a mAChR antagonist for long-term Bioactivity: Cimifugin is a major components of Yu-ping-feng-san, a Chinese treatment of irritable bowel syndrome. medical formula that is used clinically for allergic diseases and characterized by reducing allergy relapse.

Purity: 95.34% Purity: 99.97% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg

Cinchophen Cat. No.: HY-B0972 Cat. No.: HY-N1428

Bioactivity: Cinchophen is an effective method for producing chronic peptic Bioactivity: Citric acid is a weak organic tricarboxylic acid found in ulcer in dogs. citrus fruits. Citric acid is a natural preservative and food tartness enhancer.

Purity: 99.71% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 g 100 mg

CJ-42794 Cl-amidine (CJ-042794) Cat. No.: HY-10797 Cat. No.: HY-100574

Bioactivity: CJ-42794 is a selective prostaglandin E receptor subtype 4 Bioactivity: Cl-amidine is a peptidylarginine deminase (PAD) inhibitor, (EP4) antagonist, inhibits [3H]-PGE2 binding to the human EP4 with an IC50 5.9 μM for PAD4. receptor with a mean pKi of 8.5, a binding affinity that was at least 200-fold more selective for the human EP4 receptor than other human EP receptor subtypes (EP1, EP2, and EP3). Purity: 99.31% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 10 mg, 50 mg, 100 mg

Clemizole hydrochloride Cat. No.: HY-30234 Cat. No.: HY-30234A

Bioactivity: Clemizole is an H1 histamine receptor antagonist, is found Bioactivity: Clemizole hydrochloride is an H1 histamine receptor

to substantially inhibit HCV replication. The IC50 of antagonist, is found to substantially inhibit HCV replication. The IC of Clemizole for RNA binding by NS4B is Clemizole for RNA binding by NS4B is 24±1 nM, whereas its 50

EC50 for viral replication is 8 µM. 24±1 nM, whereas its EC50 for viral replication is 8 µM. Purity: >98% Purity: 99.32% Clinical Data: Launched Clinical Data: Launched Size: 5 mg, 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

Clenbuterol hydrochloride propionate Cat. No.: HY-B1614 Cat. No.: HY-13600

Bioactivity: hydrochloride is a β2 Bioactivity: is a anti-inflammatory corticosteroid agonist. It is a powerful bronchodilator withfat burning used to treat various skin disorders. properties.

Purity: 99.23% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 25 mg, 50 mg, 100 mg, 200 mg 100 mg, 200 mg, 500 mg

30 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Clofazimine fendizoate Cat. No.: HY-B1046 Cat. No.: HY-B2179

Bioactivity: Clofazimine is a fat-soluble iminophenazine dye, has a marked Bioactivity: Cloperastine fendizoate inhibits the hERG K+ currents in a anti-inflammatory effect, has been used in combination with concentration-dependent manner with an IC50 value of 27 nM. other antimycobacterial drugs to treat AIDS and Crohn's disease.

Purity: 98.78% Purity: 99.38% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 500 mg 100 mg

Clorprenaline hydrochloride Clozic Cat. No.: HY-B1347 (ICI 55897; Clobuzarit) Cat. No.: HY-100142

Bioactivity: Clorprenaline hydrochloride is a β2-adrenergic receptor Bioactivity: Clozic is a potential anti-arthritic agent. agonist.

Purity: 99.89% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 50 mg

CMI-392 CMI977 Cat. No.: HY-19205A (LDP977) Cat. No.: HY-U00260

Bioactivity: CMI-392 is a dual 5-lipoxygenese inhibitor and Bioactivity: CMI977 is a potent 5-Lipoxygenase ( 5-LO) inhibitor. platelet-activating factor ( PAF) receptor antagonist with

IC50s of 100 and 10 nM, respectively.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg

Coenzyme Q10 Columbianadin (Ubiquinone-10; CoQ10) Cat. No.: HY-N0111 Cat. No.: HY-N0362

Bioactivity: is an essential cofactor of the electron Bioactivity: Columbianadin, a natural from, is known to have transport chain and a potent antioxidant agent. various biological activities including anti-inflammatory and anti-cancer effects.

Purity: 98.0% Purity: 99.85% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 200 mg, 500 mg, 1 g, 5 g 5 mg, 10 mg, 25 mg, 50 mg

Columbin Complanatuside Cat. No.: HY-N0389 Cat. No.: HY-N1444

Bioactivity: Columbin is a diterpenoid furanolactone with anti-inflammation Bioactivity: Complanatuside is a flavonoid found in the traditional Chinese activity. medicine Semen Astragali Complanati.

Purity: 99.42% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg 5 mg, 10 mg

www.MedChemExpress.com 31

Complement factor D-IN-1 Cordycepin Cat. No.: HY-102034 (3'-Deoxyadenosine) Cat. No.: HY-N0262

Bioactivity: Complement factor D-IN-1 is a potent and selective Bioactivity: Cordycepin, which is a derivative isolated from

small-molecule reversible factor d inhibitor, with IC50s Cordyceps, inhibits IL-1β-induced MMP-1 and MMP-3 of 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay expression in rheumatoid arthritis synovial fibroblasts and a MAC Deposition Assay, respectively. (RASFs) in a dose-dependent manner.

Purity: >98% Purity: 99.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 10 mg, 25 mg, 50 mg

Cortisone (17-Hydroxy-11-dehydrocorticosterone; Kendall's Coumarin compound E) Cat. No.: HY-17461 Cat. No.: HY-N0709

Bioactivity: is a 21-carbon steroid hormone. Cortisone is one of Bioactivity: Coumarin is the primary bioactive ingredient in Radix the main released by the adrenal gland in response to Glehniae, named Beishashen in China, which possesses many stress. pharmacological activities, including anticancer, anti-inflammation and antivirus activities.

Purity: 98.63% Purity: 99.91% Clinical Data: Launched Clinical Data: Phase 4 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 100 mg, 500 mg

COX-2-IN-1 COX/5-LO-IN-1 Cat. No.: HY-U00275 Cat. No.: HY-U00347

Bioactivity: COX-2-IN-1 is potent and slective COX-2 inhibitor with an Bioactivity: COX/5-LO-IN-1 is an inhibitor of cylooxygenase and

IC50 of 3.9 μM. 5-lipoxygenase, used for the research of inflammatory and allergic disease states.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

COX2-IN-1 CP-105696 Cat. No.: HY-101655 (Pfizer 105696) Cat. No.: HY-19193

Bioactivity: COX2-IN-1 is a selective and inducible COX2 inhibitor with an Bioactivity: CP-105696 is a potent and selective Receptor IC50 of 0.24 μM. COX2-IN-1 is an anti-inflammatory compound antagonist, with an IC50 of 8.42 nM. with anti-inflammatory and analgesic activities.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 250 mg, 500 mg

CP-96486 CRAC intermediate 1 Cat. No.: HY-100316 Cat. No.: HY-20587

Bioactivity: CP-96486 is a potent and orally active leukotriene D 4 ( Bioactivity: CRAC intermediate 1 is a key intermediate in the chemical LTD )/platelet activating factor ( PAF) receptor antagonist synthesis of a series of CRAC channel inhibitors, detailed 4 information can be found in Patent WO 2010122089 A1, with K s of 20 and 24 nM, respectively. i intermediate 9.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg

32 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

CRF,bovine Crisaborole (Corticotropin Releasing Factor bovine) Cat. No.: HY-P1533 (AN-2728; PF-06930164) Cat. No.: HY-10978

Bioactivity: CRF,bovine is a potent agonist of CRF receptor, and Bioactivity: AN-2728 is a potent inhibitor of PDE4 and cytokine release; 125 inhibit PDE4 with an IC of 0.49 μM. displaces [ I-Tyr]ovine CRF with a Ki of 3.52 nM. 50

Purity: >98% Purity: 99.97% Clinical Data: No Development Reported Clinical Data: Phase 3 Size: 500u g, 1 mg, 5 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg

Cromolyn sodium CRTh2 antagonist 1 (Disodium Cromoglycate) Cat. No.: HY-B0320A Cat. No.: HY-112265

Bioactivity: Cromolyn sodium is an antiallergic drug. Target: Calcium Bioactivity: CRTh2 antagonist 1 is a CRTh2 antagonist with an

Channel Cromolyn sodium is a chromone complex that acts by IC50 of 89 nM inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an… Purity: 99.97% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 250 mg, 500 mg 1 g, 5 g

CRTH2-IN-1 CU-CPT-8m ( analog) Cat. No.: HY-U00423 (TLR8-specific antagonist) Cat. No.: HY-112050

Bioactivity: CRTH2-IN-1 (Ramatroban analog) is a selective prostaglandin D2 Bioactivity: CU-CPT-8m is a specific TLR8 antagonist, with an IC50 of 67 receptor DP2 ( CRTH2) antagonist with an IC 50 of 6 nM in a nM. human DP2 binding assay.

Purity: >98% Purity: 99.93% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

CU-CPT-9a CU-CPT-9b Cat. No.: HY-112667 (TLR8-specific antagonist 1) Cat. No.: HY-112051

Bioactivity: CU-CPT-9a is a specific TLR8 antagonist, with an IC50 of 0.5 Bioactivity: CU-CPT-9b is a specific TLR8 antagonist, with an IC50 of 0.7 nM. nM.

Purity: 98.62% Purity: 99.05% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

CU-CPT17e CV-159 Cat. No.: HY-101929 Cat. No.: HY-19025

Bioactivity: CU-CPT17e is a multi- Toll-like receptor ( TLR) agonist that Bioactivity: CV-159 is a unique dihydropyridine Ca2+ antagonist with an activates TLR3, TLR8, and TLR9. anti-calmodulin (CaM) action, and has antiinflammatory activities.

Purity: 98.02% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

www.MedChemExpress.com 33

CXCR2-IN-1 CY-09 Cat. No.: HY-101022 Cat. No.: HY-103666

Bioactivity: CXCR2-IN-1 is a central nervous system penetrant CXCR2 Bioactivity: CY-09 is an NLRP3 inhibitor.

antagonists with a pIC50 of 9.3.

Purity: 98.81% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

Cyclosporin A Cynarin (Cyclosporine; ) Cat. No.: HY-B0579 (Cynarine) Cat. No.: HY-N0359

Bioactivity: Cyclosporin A is an immunosuppressant which binds to the Bioactivity: Cynarin is an antichoke agent with a variety of biological cyclophilin and inhibits phosphatase activity of calcineurin activities including antioxidant, antihistamic and antiviral

with an IC50 of 5 nM. activities.

Purity: 98.0% Purity: 98.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 200 mg, 500 mg 5 mg, 10 mg, 25 mg

CZC24832 D-(+)-Neopterin Cat. No.: HY-15294 Cat. No.: HY-W040055

Bioactivity: CZC24832 is a highly selective and potent PI3Kγ inhibitor (IC Bioactivity: D-(+)-Neopterin, a catabolic product of triphosphate app (GTM), serves as a marker of cellular immune system 50=27 nM) with apparent dissociation constants ( Kd ) of activation. 19 nM.

Purity: 98.01% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg

D-Panthenol D18024 (Dexpanthenol) Cat. No.: HY-B1391 Cat. No.: HY-U00210

Bioactivity: D-Panthenol is the biologically-active of pantothenic Bioactivity: D18024 is a phthalazinonderivat antiallergic and acid, which leads to an elevation in the amount of coenzyme A antihistaminic activity. in the cell.

Purity: 98.28% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 1 g

Dagrocorat Danirixin Cat. No.: HY-16718 (GSK1325756) Cat. No.: HY-19768

Bioactivity: Dagrocorat is a novel and dissociated Glucocorticoid Receptor Bioactivity: Danirixin is a selective, and reversible CXCR2 antagonist,

Agonist. with IC50of12.5 nM for CXCL8.

Purity: >98% Purity: 98.23% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

34 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Daphylloside Darbufelone mesylate Cat. No.: HY-N6245 (CI-1004 mesylate) Cat. No.: HY-101438A

Bioactivity: Daphylloside is an iridoid isolated from the aerial parts of Bioactivity: Darbufelone mesylate is a dual inhibitor of cellular PGF2α Galium verum. and LTB4 production. Darbufelone potently inhibits PGHS-2 (

IC50 = 0.19 μM) but is much less potent with PGHS-1 ( IC50= 20 μM). Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

DDR1-IN-2 Decernotinib Cat. No.: HY-U00444 (VX-509; VRT-831509) Cat. No.: HY-12469

Bioactivity: DDR1-IN-2 is a potent inhibitor of discoidin domain receptor 1 Bioactivity: Decernotinib is a potent, orally active JAK3 inhibitor, with

( DDR1), with an IC50 of 13.1 nM, and also less potently Kis of 2.5, 11, 13 and 11 nM for JAK3, JAK1, JAK2, and TYK2,

inhibits DDR2, with an IC50 of 203 nM. respectively.

Purity: >98% Purity: 98.91% Clinical Data: No Development Reported Clinical Data: Phase 3 Size: 5 mg, 10 mg, 25 mg Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg

Decloxizine Decloxizine dihydrochloride (UCB-1402; NSC289116) Cat. No.: HY-17582 (UCB 1402 dihydrochloride) Cat. No.: HY-A0075

Bioactivity: Decloxizine(UCB-1402; NSC289116) is a histamine 1 receptor Bioactivity: Decloxizine dihydrochloride(UCB-1402; NSC289116) is a antagonist. histamine 1 receptor antagonist.

Purity: >98% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 50 mg, 100 mg, 500 mg Size: 10mM x 1mL in DMSO, 50 mg, 100 mg, 500 mg

Decursin ((+)-Decursin) Cat. No.: HY-18981 Cat. No.: HY-13609

Bioactivity: Decursin is an anticancer agent, with potential Bioactivity: Deflazacort is a glucocorticoid used as an anti-inflammatory anti-inflammatory activity. and immunosuppressant.

Purity: 99.98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg 50 mg, 100 mg

Delgocitinib Deloxolone (JTE-052) Cat. No.: HY-109053 Cat. No.: HY-U00278

Bioactivity: Delgocitinib is a novel and specific JAK inhibitor with IC50s Bioactivity: Deloxolone can be used to treat and prevent inflammatory, of 2.8, 2.6, 13 and 58 nM for JAK1, JAK2, JAK3 and Tyk2, ischemic and proliferative diseases. respectively.

Purity: 99.14% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

www.MedChemExpress.com 35

Demethoxycurcumin ( II; Desmethoxycurcumin; Monodemethoxycurcumin)Cat. No.: HY-N0006 (SC 046; SC 46; SC 59046) Cat. No.: HY-17509

Bioactivity: Demethoxycurcumin(Curcumin II) is a major active ; Bioactivity: Deracoxib, a selective cyclooxygenase-2 inhibitor, is a possess anti-inflammatory properties; also exert cytotoxic non-narcotic, non-steroidal anti-inflammatory drug (NSAID). effects in human cancer cells via induction of apoptosis. IC50 value: Target: in vitro: DMC significantly decreased NO secretion by 35-41% in our inflamed cell model. Decrease in NO… Purity: 99.09% Purity: 99.82% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 100 mg, 500 mg

Desisobutyryl-ciclesonide (CIC-AP; Ciclesonide active principle) Cat. No.: HY-111490 (Sch34117) Cat. No.: HY-B0539

Bioactivity: Desisobutyryl-ciclesonide is the active metabolite of Bioactivity: Desloratadine(Sch34117) is a potent antagonist for human Ciclesonide. Desisobutyryl-ciclesonide has affinity for the histamine H1 receptor used to treat allergies. glucocorticoid receptor.

Purity: 99.53% Purity: 99.75% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg 50 mg, 100 mg, 500 mg

Desonide Cat. No.: HY-B0248 Cat. No.: HY-17570

Bioactivity: is a nonfluorinated corticosteroid anti-inflammatory Bioactivity: Desoximetasone(Topicort) is a medication belonging to the agent used topically for dermatoses. family of known as topical ; is used for the relief of various skin conditions, including rashes.

Purity: 99.81% Purity: 98.82% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg 1 g, 5 g

Dexamethasone 9,11-epoxide (Hexadecadrol; Prednisolone F) Cat. No.: HY-14648 Cat. No.: HY-N0348

Bioactivity: Dexamethasone is a glucocorticoid receptor agonist. Bioactivity: Dexamethasone 9,11-epoxide, a compound extracted from patent CN 106520896 A and RU 2532902 C1, is an intermediate in the preparation of dexamethasone.

Purity: 99.70% Purity: 99.27% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g 10 mg, 50 mg, 100 mg, 200 mg, 500 mg

Dexamethasone acetate Dexamethasone phosphate disodium (Dexamethasone 21-acetate) Cat. No.: HY-14648A (Dexamethasone 21-phosphate disodium salt) Cat. No.: HY-B1829A

Bioactivity: is a glucocorticoid receptor agonist. Bioactivity: Dexamethasone phosphate disodium is a glucocorticoid receptor agonist.

Purity: 99.34% Purity: 99.68% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 1 g, 5 g 100 mg, 500 mg

36 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Dexchlorpheniramine maleate diABZI STING agonist-1 (S-(+)-Chlorpheniramine maleate salt) Cat. No.: HY-B1062 Cat. No.: HY-112921

Bioactivity: maleate is an antihistamine, with Bioactivity: diABZI STING agonist-1 is a selective stimulator of interferon

properties, used to treat allergic conditions. genes (STING) receptor agonist, with an EC50s of 130 for human PBMCs.

Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 200 mg diABZI STING agonist-1 Tautomerism diABZI STING agonist-1 Tautomerism trihydrochloride Cat. No.: HY-112921A Cat. No.: HY-112921B

Bioactivity: diABZI STING agonist-1 (Tautomerism) is a selective stimulator Bioactivity: diABZI STING agonist-1 (Tautomerism trihydrochloride) is a of interferon genes (STING) receptor agonist. selective stimulator of interferon genes (STING) receptor agonist.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 500 mg, 250 mg

Diacerein Diarylalkane derivative 1 (Diacerhein; Diacetylrhein; Fisiodar; Artrodar) Cat. No.: HY-N0283 Cat. No.: HY-U00384

Bioactivity: , a interleukin-1 beta inhibitor, is a slow-acting Bioactivity: Diarylalkane derivative 1 is used for the research of medicine of the class anthraquinone used to treat joint pancreatitis. diseases.

Purity: 98.78% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 50 mg, 100 mg

Dichlorisone acetate Diclofenac Cat. No.: HY-B1383 Cat. No.: HY-15036

Bioactivity: acetate is a synthetic glucocorticoid Bioactivity: Diclofenac is a potent and nonselective anti-inflammatory

corticosteroid used as an anti-inflammatory agent. agent, acts as a COX inhibitor, with IC50s of 4 nM, 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1, 0.84 μM for ovine COX-1 and COX-2, respectively.

Purity: 99.61% Purity: 99.98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 5 g, 10 g

Diclofenac diethylamine Diclofenac Sodium Cat. No.: HY-15036A Cat. No.: HY-15037

Bioactivity: Diclofenac diethylamine is a potent and nonselective Bioactivity: Diclofenac Sodium is a potent and nonselective

anti-inflammatory agent, acts as a COX inhibitor, with IC50s anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 nM, 1.3 nM for human COX-1 and COX-2 in CHO cells, and of 4 nM, 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1, 0.84 μM for ovine COX-1 and COX-2, respectively. 5.1, 0.84 μM for ovine COX-1 and COX-2, respectively.

Purity: >98% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 5 g, 10 g Size: 10mM x 1mL in Water, 5 g

www.MedChemExpress.com 37

Diflorasone Diflumidone Cat. No.: HY-A0158 (R807) Cat. No.: HY-100139

Bioactivity: is a potent topical anti-inflammatory steroid. Bioactivity: Diflumidone is a non-steroidal antiinflammatory drug.

Purity: 99.62% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Diflunisal (MK-647) Cat. No.: HY-18342 Cat. No.: HY-17569

Bioactivity: (MK-647) is a salicylate derivative with Bioactivity: Difluprednate(Durezol) is a corticosteroid, approved nonsteroidal anti-inflammatory and uricosuric properties, difluprednate for the treatment of post-operative ocular which is used alone as an analgesic and in rheumatoid inflammation and pain. arthritis patients. The mechanism of action of diflunisal is as a Cyclooxygenase ( COX) Inhibitor. Purity: 99.37% Purity: 99.49% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 100 mg, 500 mg

Digeranyl bisphophonate Digoxigenin (DGBP) Cat. No.: HY-U00145 (Lanadigenin) Cat. No.: HY-B1025

Bioactivity: Digeranyl bisphophonate is a potent Bioactivity: Digoxigenin is a hapten, a small molecule with high geranylgeranylpyrophosphate (GGPP) synthase inhibitor, which antigenicity, that is used in many molecular biology inhibits geranylgeranylation of Rac1. applications, as an alternative probe labeling for in situ hybridization

Purity: >98% Purity: 99.70% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: Size: 10mM x 1mL in DMSO, 10 mg, 50 mg

Dilmapimod Dimemorfan phosphate (SB-681323; GW 681323) Cat. No.: HY-10404 Cat. No.: HY-B2215

Bioactivity: SB-681323 is a potent p38 MAPK inhibitor that potentially Bioactivity: Dimemorfan phosphate is a sigma 1 receptor agonist, used suppresses inflammation in chronic obstructive pulmonary as a potent antitussive. disease.

Purity: 99.56% Purity: 98.42% Clinical Data: Phase 2 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 20 mg 50 mg, 100 mg

Dimethyl fumarate hydrochloride (DMF) Cat. No.: HY-17363 (DPH) Cat. No.: HY-B0303A

Bioactivity: Dimethyl fumarate is a nuclear factor (erythroid-derived)-like Bioactivity: Diphenhydramine HCl (Benadryl), a histamine H1 antagonist used 2 ( Nrf2) pathway activator and induces upregulation of as an antiemetic, antitussive, for dermatoses and pruritus, antioxidant gene expression. for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. Purity: 98.0% Purity: 99.75% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 g 250 mg, 500 mg, 5 g

38 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Diphenyleneiodonium chloride Dipsacoside B (DPI) Cat. No.: HY-100965 Cat. No.: HY-N0266

Bioactivity: Diphenyleneiodonium chloride is a NADPH oxidase ( NOX) Bioactivity: Dipsacoside B is a major bioactive saponin, which can be used inhibitor and also functions as a TRPA1 activator with an as a marker.

EC50 of 1 to 3 μM.

Purity: 99.87% Purity: >98% Clinical Data: Phase 4 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 25 mg 10 mg, 50 mg, 100 mg

Dipyrocetyl Diquafosol tetrasodium Cat. No.: HY-B1179 (INS365) Cat. No.: HY-B0606

Bioactivity: is an anti-inflammatory and analgesic agent Bioactivity: Diquafosol tetrasodium is a P2Y2 receptor agonist that extracted from patent WO 2011132171 A1. stimulates fluid and mucin secretion on the ocular surface, as a topical treatment of dry eye disease.

Purity: 98.39% Purity: 99.93% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 10 mg 5 mg, 10 mg, 50 mg, 100 mg

Dithranol DL-α-Tocopherol acetate (Anthralin) Cat. No.: HY-B0738 ( acetate) Cat. No.: HY-B1278A

Bioactivity: is highly effective in the treatment of psoriasis. Bioactivity: DL-α-Tocopherol acetate is a vitamin E derivative which is often included in the formulations of enteral nutrition.

Purity: 98.0% Purity: 98.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 100 mg

DMP 777 Doramapimod (L-694458) Cat. No.: HY-75957 (BIRB 796) Cat. No.: HY-10320

Bioactivity: DMP 777 is a potent, selective, and orally active human Bioactivity: Doramapimod (BIRB 796) is a highly potent p38 MAPK leukocyte elastase (HLE) inhibitor. inhibitor with an IC50 of 4 nM. It also inhibits B-Raf with

an IC50 of 83 nM.

Purity: 98.59% Purity: 99.72% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 5 mg, 10 mg, 25 mg, 50 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg, 200 mg

Doxofylline succinate Cat. No.: HY-B0004 Cat. No.: HY-A0069

Bioactivity: is an antagonist of which Bioactivity: Doxylamine is a first generation antihistamine; can be used by also inhibits phosphodiesterase IV. itself as a short-term sedative and in combination with other drugs to provide night-time allergy and cold relief.

Purity: 99.88% Purity: 99.77% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 100 mg

www.MedChemExpress.com 39

DPP-IV-IN-2 DprE1-IN-1 Cat. No.: HY-108319 (AZ 7371) Cat. No.: HY-19750

Bioactivity: DPP-IV-IN-2 is an inhibitor of both dipeptidyl peptidase IV ( Bioactivity: DprE1-IN-1 is a potent DprE1 inhibitor, with ic50 of 10 nM, also inhibits PDE6, with IC50 of 6 uM. DPIV) and DP8/9 with IC50s of 0.1 and 0.95 μM, respectively.

Purity: 98.0% Purity: 99.94% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg 2 mg, 5 mg, 10 mg, 50 mg, 100 mg

Dropropizine DW-1350 ((±)-; UCB-196) Cat. No.: HY-B1032 Cat. No.: HY-100173

Bioactivity: Dropropizine is a racemic non- antitussive agent which Bioactivity: DW-1350 is a LTB4 receptor antagonist. has been used clinically for many years.

Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 100 mg

DZ2002 E-64 Cat. No.: HY-18620 Cat. No.: HY-15282

Bioactivity: DZ2002 is a potent and reversible S-Adenosyl-L-homocysteine Bioactivity: E-64 is a potent irreversible inhibitor against general

Hydrolase(SAHH; AdoHcy Hydrolase) inhibitor with Ki of 17.9 cysteine proteases with IC50 of 9 nM for papain. nM.

Purity: 99.85% Purity: 99.62% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg

E-​6123 E3 Ligase Ligand-Linker Conjugates 24 TFA Cat. No.: HY-10164 (E3 Ligase Ligand-Linker Conjugates 24 trifluoroacetate) Cat. No.: HY-112617A

Bioactivity: E-​6123 is a platelet-activating factor ( PAF) receptor Bioactivity: E3 Ligase Ligand-Linker Conjugates 24 (TFA) incorporates an E3 antagonist. ligase ligand and a linker, can be an immunomodulater for the treatment of cancer.

Purity: >98% Purity: 99.52% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 100 mg, 500 mg, 1 g, 2 g

E6130 Cat. No.: HY-107456 (LAS-W 090; RP64305) Cat. No.: HY-B0674

Bioactivity: E6130 is an orally available and highly selective CX3CR1 Bioactivity: Ebastine(LAS-W 090;RP64305) is a long-acting and selective modulator, that may be effective for treatment of inflammatory H1-histamine receptor antagonist. Target: Histamine H1 bowel disease. Receptor Ebastine is a H1 antihistamine with low potential for causing drowsiness. Ebastine (10 mg orally) causes brain histamine H1-receptor occupation of approximately 10%,… Purity: >98% Purity: 99.96% Clinical Data: No Development Reported Clinical Data: Phase 4 Size: 250 mg, 500 mg Size: 10mM x 1mL in Ethanol, 500 mg, 1 g, 5 g

40 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Ebrotidine Ebselen (FI3542) Cat. No.: HY-15538 (SPI-1005; PZ-51; CCG-39161) Cat. No.: HY-13750

Bioactivity: (FI 3542) is a competitive H2-receptor antagonist Bioactivity: Ebselen is a small-molecule capsid Inhibitor of HIV-1 (Ki= 127.5 nM) with a potent antisecretory activity and replication. Target: Ebselen is an organoselenium compound, as evidenced gastroprotection. an inhibitor of HIV-1 capsid CTD dimerization. Ebselen inhibits early viral postentry events of the HIV-1 life cycle by impairing the incoming capsid uncoating process. [1]… Purity: 97.78% Purity: 99.89% Clinical Data: No Development Reported Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg

Echinocystic acid Edicotinib Cat. No.: HY-N0271 (JNJ-40346527) Cat. No.: HY-109086

Bioactivity: Echinocystic acid a pentacyclic triterpene isolated from the Bioactivity: Edicotinib is a selective and orally available fruits of Gleditsia sinensis Lam, has potent antioxidant, colony-stimulating factor-1 (CSF-1) receptor inhibitor, anti-inflammatory and anti-tumor properties. and has entered phase IIA clinical trial to study rheumatoid arthritis (RA) despite disease.

Purity: 98.08% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 5 mg, 10 mg

Efavirenz EIPA (DMP 266; EFV; L-743726) Cat. No.: HY-10572 (L593754; MH 12-43; Ethylisopropylamiloride) Cat. No.: HY-101840

Bioactivity: is a potent inhibitor of the wild-type HIV-1 reverse Bioactivity: EIPA is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. transcriptase with a K of 2.93 nM and exhibits an IC of 1.5 i 95 EIPA also inhibits Na+/H+-exchanger ( NHE) and nM for the inhibition of HIV-1 replicative spread in cell macropinocytosis. culture.

Purity: 99.99% Purity: 99.73% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg

Eleutheroside E Cat. No.: HY-N0272 Cat. No.: HY-U00132

Bioactivity: Eleutheroside E, a principal component of Eleutherococcus Bioactivity: Embramine is a monoethanolamine used as an antihistamine and enticosus, has anti-inflammatory and protective effects in anticholinergic. ischemia heart.

Purity: 99.65% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 50 mg, 100 mg

Emeramide Enazadrem (BDTH2) Cat. No.: HY-16739 Cat. No.: HY-U00024

Bioactivity: Emeramide is a novel lipid-soluble, thiol-redox antioxidant Bioactivity: Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory and heavy metal chelator. activities.

Purity: 99.56% Purity: 97.26% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 100 mg, 500 mg

www.MedChemExpress.com 41

Endothelin 1 swine, human Engeletin Cat. No.: HY-P0202 Cat. No.: HY-N0436

Bioactivity: 1 (swine, human) is a synthetic peptide with the Bioactivity: Engeletin is a flavanonol glycoside isolated from hymenaea Sequence: Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr- martiana, inhibits NF-κB signaling-pathway activation, and Phe-Cys-His-Leu-Asp-Ile-Ile-Trp(Disulfide bridge: possesses anti-inflammatory, analgesic, diuresis, Cys1-Cys15,Cys3-Cys11). detumescence, and antibiosis effects.

Purity: 96.85% Purity: 98.88% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500u g, 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Epinastine ERA63 (WAL801) Cat. No.: HY-B0640 Cat. No.: HY-U00093

Bioactivity: (WAL801) is an antihistamine and mast cell Bioactivity: ERA63 is a selective estrogen receptor α agonist. stabilizer that is used in eye drops to treat .

Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 50 mg, 100 mg, 500 mg

ERB-196 Ergosterol (WAY-202196) Cat. No.: HY-19468 (Ergosterin; Provitamin D; Provitamin D2) Cat. No.: HY-N0181

Bioactivity: ERB-196 is a nonsteroidal selective estrogen receptor-β ( Bioactivity: Ergosterol is the primary sterol found in fungi, with ERβ) agonist. antioxidative, anti-proliferative, and anti-inflammatory effects.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 100 mg

Eriodictyol Esonarimod (Huazhongilexone) Cat. No.: HY-N0637 (KE-298) Cat. No.: HY-19440

Bioactivity: Eriodictyol is a flavonoid isolated from the Chinese herb, Bioactivity: Esonarimod is an antirheumatic drug. with antioxidant and anti-inflammatory activity. Eriodictyol induces Nrf2 signaling pathway.

Purity: >98% Purity: 99.81% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

Ethoxzolamide (Redupresin; L-643786; PNU-4191) Cat. No.: HY-B1480 Cat. No.: HY-76251

Bioactivity: Ethoxzolamide is a carbonic anhydrase inhibitor with Ki of 1 Bioactivity: Etodolac is a non-steroidal anti-inflammatory compound that is nM. a non-selective inhibitor of COX (IC50=53.5 nM)

Purity: 98.78% Purity: 99.10% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 50 mg, 100 mg

42 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Etofenamate Cat. No.: HY-17361 (MK-663; MK-0663) Cat. No.: HY-15321

Bioactivity: is a non-steroidal anti-inflammatory drug used for Bioactivity: Etoricoxib is a non steroidal anti-inflammatory agent, acting

the treatment joint and muscular pain. as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.

Purity: 98.99% Purity: 99.92% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 10 mg, 50 mg, 100 mg

Etosalamide Etrasimod (Ethosalamide) Cat. No.: HY-B1015 (APD334) Cat. No.: HY-12789

Bioactivity: Etosalamide is an antipyretic and , used as an Bioactivity: Etrasimod (APD334) is a potent, selective and orally available

anti-inflammatory drug. antagonist of the sphingosine-1-phosphate-1 ( S1P1) receptor

with an IC50 value of 1.88 nM in CHO cells.

Purity: >98% Purity: 99.64% Clinical Data: Launched Clinical Data: Phase 2 Size: 10 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

Eugenol Eupatilin Cat. No.: HY-N0337 Cat. No.: HY-N0783

Bioactivity: Eugenol is an essential oil found in cloves with Bioactivity: Eupatilin, a lipophilic flavonoid isolated from Artemisia antibacterial, anthelmintic and antioxidant activity. Eugenol species, is a PPARα agonist, and possesses anti-apoptotic, is shown to inhibit lipid peroxidation. anti-oxidative and anti-inflammatory activities.

Purity: 99.86% Purity: 99.01% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 5 mg, 10 mg, 25 mg, 50 mg

Felbinac (4-Biphenylacetic acid) Cat. No.: HY-B0641 (CL-82204) Cat. No.: HY-B1138

Bioactivity: is a potent non-steroidal anti-inflammatory agent, Bioactivity: Fenbufen is a non-steroidal anti-inflammatory drug in the used to treat muscle inflammation and arthritis. derivatives class.

Purity: 99.93% Purity: 98.47% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g 100 mg

Fenclozine Calcium Cat. No.: HY-19017 Cat. No.: HY-B0288A

Bioactivity: Fenclozine is a non-steroidal antiinflammatory drug extracted Bioactivity: Fenoprofen Calcium is a nonsteroidal, anti-inflammatory from patent WO 2012112690 A2. antiarthritic agent.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg Size: 1 g, 5 g

www.MedChemExpress.com 43

Fenoprofen Calcium hydrate Hydrochloride (Fenoprofen calcium salt dihydrate) Cat. No.: HY-B0288B Cat. No.: HY-A0027

Bioactivity: Fenoprofen Calcium hydrate is a nonsteroidal, Bioactivity: Fenspiride Hcl is an α adrenergic and H1 histamine receptor anti-inflammatory antiarthritic agent. Target: Prostaglandin antagonist. G/H synthase 1 Fenoprofen is a non-steroidal anti-inflammatory, antipyretic, analgesic agent advocated for use in rheumatoid arthritis, degenerative joint disease,… Purity: 99.35% Purity: 99.03% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g 100 mg

Fibrinopeptide B, human Fingolimod (FPB,human) Cat. No.: HY-P1493 (FTY720 free base) Cat. No.: HY-11063

Bioactivity: Fibrinopeptide B, human is a 14-aa peptide, released from the Bioactivity: Fingolimod is a sphingosine 1-phosphate ( S1P) antagonist amino-terminus of β-chains of fibrinogen by thrombin. with IC50 of 0.033 nM in K562 and NK cells.

Purity: >98% Purity: 99.95% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg

Fingolimod hydrochloride FIPI (FTY720) Cat. No.: HY-12005 (5-Fluoro-2-indolyl deschlorohalopemide) Cat. No.: HY-12807

Bioactivity: Fingolimod hydrochloride is a sphingosine 1-phosphate ( S1P) Bioactivity: FIPI is a derivative of halopemide which potently inhibits both PLD1 and PLD2 with IC s of 25 nM and 20 nM, antagonist with an IC50 of 0.033 nM in K562 and NK cells. 50 respectively.

Purity: 99.76% Purity: 99.07% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 200 mg, 1 g, 5 g 5 mg, 10 mg, 50 mg, 100 mg

Firocoxib Fisetin (ML 1785713) Cat. No.: HY-14670 Cat. No.: HY-N0182

Bioactivity: (ML 1785713) is a potent and selective cyclooxygenase Bioactivity: Fisetin is a natural flavonol found in many fruits and (COX)-2 inhibitor with IC50 of 0.13 uM, 58 fold sensitivity vegetables with various benefits, such as antioxidant, for COX2 VSCOX1. anticancer, neuroprotection effects.

Purity: 99.50% Purity: 98.0% Clinical Data: Launched Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 100 mg, 500 mg, 1 g

FK 3311 FKK Cat. No.: HY-14445 Cat. No.: HY-100194

Bioactivity: FK 3311 is a selective inhibitor of COX-2; antiinflammatory Bioactivity: FKK is an indazole derivative and also a novel bronchodilator. agent.

Purity: 98.06% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 10 mg, 50 mg

44 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

FLAG peptide Flosulide Cat. No.: HY-P0223 (ZK 38997; CGP 28238) Cat. No.: HY-U00083

Bioactivity: FLAG peptide is an eight amino acids peptide Bioactivity: Flosulide is a potent and selective COX-2 inhibitor, used for (Asp-Tyr-Lys-Asp-Asp-Asp-Asp-Lys) with an the treatment for inflammatory diseases. enterokinase-cleavage site; designed for antibody-mediated identification and purification of recombinant proteins.Sequence: Asp-Tyr-Lys-Asp-Asp-Asp-Asp-Lys. Purity: 98.67% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 25 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

Fludrocortisone acetate (9α-Fludrocortisone; 9α-Fluorcortisol) Cat. No.: HY-B1203 (9α-Fludrocortisone acetate; 9α-Fluorcortisol acetate) Cat. No.: HY-B1203A

Bioactivity: Fludrocortisone, a synthetic mineralocorticoid with Bioactivity: Fludrocortisone Acetate is a synthetic mineralocorticoid, used anti-inflammatory activity. to control the amount of sodium and fluids in your body. It is used to treat Addison's disease by decreasing the amount of sodium that is lost (excreted) in your urinealso used to increase blood pressure. Purity: >98% Purity: 99.45% Clinical Data: Launched Clinical Data: Launched Size: 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 100 mg

Flufenamic acid Flumethasone Cat. No.: HY-B1221 () Cat. No.: HY-B1051

Bioactivity: is a non-steroidal anti-inflammatory agent, Bioactivity: Flumethasone is a corticosteroid for topical use, in inhibits cyclooxygenase ( COX), activates AMPK, and also combination with Clioquinol for the treatment of otitis modulates ion channels, blocking chloride channels and L-type externa and otomycosis. Flumethasone shows fully 420 times the Ca2+ channels, modulating non-selective cation channel… potency of cortisone in an animal model for anti-inflammatory activity. Purity: 99.92% Purity: 99.40% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 50 mg, 100 mg, 250 mg

Flunisolide meglumine Cat. No.: HY-B1121 Cat. No.: HY-B0386

Bioactivity: is a corticosteroid often used to treat allergic Bioactivity: Flunixin Meglumine is a potent inhibitor of COX used as rhinitis.The principal mechanism of action of Flunisolide is analgesic agent with anti-inflammatory and antipyretic to activate glucocorticoid receptors, meaning it has an activity. anti-inflammatory action.

Purity: 99.61% Purity: 99.65% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 100 mg 1 g, 5 g

Fluocinolone Acetonide Cat. No.: HY-B0415 Cat. No.: HY-B0485

Bioactivity: Acetonide is a glucocorticoid derivative used Bioactivity: Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically in the treatment of various skin disorders. topically as anti-inflammatory agent for the treatment of skin disorders. Target: Glucocorticoid Receptor Fluocinonide is a potent glucocorticoid steroid used topically as an anti-inflammatory agent for the treatment of skin disorders… Purity: 98.58% Purity: 99.42% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g 100 mg, 500 mg

www.MedChemExpress.com 45

Flurandrenolide (; Flurandrenolone) Cat. No.: HY-B1013 (dl-Flurbiprofen) Cat. No.: HY-10582

Bioactivity: Fludroxycortide is a synthetic and is used as Bioactivity: Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) an anti-inflammatory treatment for use on skin irritations. with antipyretic and analgesic activity. Target: PGE synthase Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for… Purity: 99.83% Purity: 99.75% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 25 mg 100 mg, 500 mg

Fluticasone propionate FM381 Cat. No.: HY-B0154 Cat. No.: HY-102046

Bioactivity: propionate is a high affinity, selective GR Bioactivity: FM381 is a potent covalent reversible inhibitor of JAK3 (glucocorticoid receptor) agonist which is derived from targeting the unique Cys909 at the gatekeeper position +7 in

fluticasone used to treat asthma and allergic rhinitis. JAK3. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 Target: Glucocorticoid Receptor is a and 3600-fold selectivity over JAK1, JAK2 and TYK2, corticosteroid derived from fluticasone used to treat asthma… respectively. Purity: 99.57% Purity: 98.41% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Fmoc-Thr[GalNAc(Ac)3-α-D]-OH Fodipir (Fmoc-Thr(Ac₃AcNH-α-Gal)-OH) Cat. No.: HY-P0232 (DPDP) Cat. No.: HY-108869

Bioactivity: Fmoc-Thr[GalNAc(Ac)3-α-D]-OH is a building block in the Bioactivity: Fodipir is an active metabolite of mangafodipir, involved in development of cancer . mangafodipir-mediated cytoprotection against 7β-hydroxycholesterol-induced cell death.

Purity: 97.72% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 25 mg, 50 mg, 100 mg Size: 250 mg, 500 mg

Forsythoside B Cat. No.: HY-N0029 (PF-04171327) Cat. No.: HY-16722

Bioactivity: Forsythoside B is a phenylethanoid glycoside isolated from the Bioactivity: Fosdagrocorat (PF-04171327) is a dissociated glucocorticoid leaves of Lamiophlomis rotata Kudo, a Chinese folk medicinal receptor agonist. plant for treating inflammatory diseases and promoting blood circulation. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate NF-κB. Purity: 99.84% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

FPL59360 FR-188582 (Minocromil) Cat. No.: HY-U00258 Cat. No.: HY-U00146

Bioactivity: FPL59360 is a new Anti-asthmatic agent. Bioactivity: FR-188582 is a highly selective inhibitor of cyclooxygenase (

COX)-2, with an IC50 value of 17 nM.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

46 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

FR167344 free base FR183998 free base Cat. No.: HY-100301 Cat. No.: HY-100302

Bioactivity: FR167344 free base is an orally active, nonpeptide Bioactivity: FR183998 free base is a potent Na+/H+-exchange inhibitor, receptor B2 antagonist. FR167344 free base shows a high with IC50s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pH i affinity binding to the B2 receptor with an IC value of 65 50 change in rat lymphocytes, rat and human platelets, nM and no binding affinity for the B1 receptor. respectively. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg

Frentizole FRG8701 Cat. No.: HY-15374 Cat. No.: HY-U00238

Bioactivity: Frentizole, an FDA-approved , is a novel Bioactivity: FRG-8701 is a new Histamine H2-receptor antagonist with inhibitor of the Aβ-ABAD interaction. an IC50 of ranging from 0.25 to 0.43 μM.

Purity: 99.01% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg

FT011 FTY720 (S)-Phosphate Cat. No.: HY-100495 ((S)-FTY720P; (S)-FTY720 phosphate) Cat. No.: HY-15382

Bioactivity: FT011, a new anti-fibrotic and an anti-inflammatory agent, Bioactivity: FTY720 (S)-Phosphate is an agonist of S1P receptor 1 prevents glycogen accumulation by reducing glycogenin mRNA (S1PR1), used in the research of acute inflammatory diseases translation. such as acute lung injury.

Purity: 98.89% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg 2 mg, 5 mg, 10 mg, 50 mg, 100 mg

Fucoxanthin (all-trans-) Cat. No.: HY-N2302 (XEN402) Cat. No.: HY-16723

Bioactivity: Fucoxanthin is a marine carotenoid and shows anti-obesity, Bioactivity: Funapide is a potent Nav1.7 inhibitor. anti-diabetic, anti-oxidant, anti-inflammatory and anticancer activities.

Purity: 99.17% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Furaltadone hydrochloride Fursultiamine Cat. No.: HY-B1148 Cat. No.: HY-B2082

Bioactivity: Furaltadone hydrochloride is effective against chronic Bioactivity: Fursultiamine is a vitamin B1 derivative. respiratory disease complex and paratyphoid infections, and has shown marked in vitro activity against Vibrio fetus.

Purity: 98.83% Purity: 99.72% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

www.MedChemExpress.com 47

FX1 Gabexate mesylate Cat. No.: HY-102027 (FOY) Cat. No.: HY-B0385

Bioactivity: FX1 is a potent and specific BCL6 inhibitor, with an IC50 of Bioactivity: Gabexate Mesylate is a inhibitor. around 35 μM.

Purity: 98.0% Purity: 98.51% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg 10 mg, 100 mg

GAL-021 Galantide Cat. No.: HY-101422 Cat. No.: HY-P0262

Bioactivity: GAL-021 a new intravenous BKCa-. Bioactivity: Galantide is a reversible and non-specific receptor antagonist. Sequence: Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu- Leu-Gly-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2.

Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 500u g, 1 mg, 5 mg 5 mg, 10 mg, 50 mg, 100 mg

Gastrodin Gastrofensin AN 5 free base (Gastrodine) Cat. No.: HY-N0115 Cat. No.: HY-100296

Bioactivity: Gastrodin, a main constituent of a Chinese herbal medicine Bioactivity: Gastrofensin AN 5 free base, a 4-phenyl-tetrahydroisoquinoline Tianma, has been known to display anti-inflammatory effects. derivative, is an antiulcer agent. Gastrodin, has long been used for treating dizziness, epilepsy, stroke and dementia.

Purity: 99.40% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 25 mg, 50 mg, 100 mg

GDC-0834 GDC-0834 Racemate Cat. No.: HY-15427 Cat. No.: HY-15427A

Bioactivity: GDC-0834 is a potent and selective BTK inhibitor. GDC-0834 Bioactivity: GDC-0834 Racemate is the racemate form of GDC-0834, which is a potent and selective BTK inhibitor with in vitro IC50s of 5.9 inhibits BTK with an in vitro IC50 of 5.9 and 6.4 nM in biochemical and cellular assays, respectively, and in vivo and 6.4 nM in biochemical and cellular assays, respectively. IC of 1.1 and 5.6 μM in mouse and rat, respectively. IC50 value: 5.9 nM/6.4 nM(biochemical/cellular assay) [1] 50 Target: BTK in vitro: GDC-0834 inhibited BTK with an in vitro… Purity: 99.07% Purity: 95.47% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg

Gefapixant Gefarnate (AF219; MK-7264) Cat. No.: HY-101588 Cat. No.: HY-B2206

Bioactivity: is an orally active P2X3 receptor ( P2X3R) Bioactivity: Gefarnate is a drug used for the treatment of gastritis and

antagonist with IC 50s of ~30 nM versus recombinant hP2X3 gastric ulcer, and has been proposed for use in the treatment homotrimers and 100-250 nM at hP2X2/3 heterotrimeric of dry eye syndrome. receptors.

Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 50 mg, 100 mg

48 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Gemilukast Genkwanin (ONO-6950) Cat. No.: HY-16780 (Puddumetin) Cat. No.: HY-N0731

Bioactivity: Gemilukast is an orally active and potent dual cysteinyl Bioactivity: Genkwanin is a major non-glycosylated flavonoid with

leukotriene 1 and 2 receptors (CysLT1 and CysLT2) anti-flammatory activities.

antagonist, with IC50s of 1.7, 25 nM for human CysLT 1 and

CysLT 2, respectively. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 5 mg, 10 mg, 50 mg

Gentiopicroside GENZ-882706 (Gentiopicrin) Cat. No.: HY-N0494 (RA03546849) Cat. No.: HY-101526

Bioactivity: Gentiopicroside, a naturally occurring iridoid glycoside, Bioactivity: GENZ-882706 is a potent colony stimulating factor-1 receptor (

inhibits P450 activity, with an IC 50 and a K i of 61 µM and CSF-1R) Inhibitor extracted from patent WO 2017015267A1. 22.8 µM for CYP2A6; Gentiopicroside has antianti-inflammatoryand antioxidative effects.

Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 25 mg, 50 mg 10 mg, 25 mg, 50 mg, 100 mg

Geraniin Gestrinone Cat. No.: HY-N0472 (R 2323) Cat. No.: HY-101405

Bioactivity: Geraniin is a TNF-α releasing inhibitor with numerous Bioactivity: Gestrinone (R2323) is a synthetic steroid hormone used to

activities including anticancer, anti-inflammatory, and treat endometriosis. It inhibits leiomyoma cells with an IC50 anti-hyperglycemic activities, with an IC of 43 μM. 50 of 43.67 μM.

Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg

Ginkgetin Ginkgolide A Cat. No.: HY-N0889 Cat. No.: HY-B0355

Bioactivity: Ginkgetin is a natural biflavonoid isolated from leaves of Bioactivity: Ginkgolide A is an extract from in Ginkgo biloba and a Ginkgo biloba L; effects of anti-inflammation and anticancer g-aminobutyric acid (GABA) antagonist. have been reported. IC50 value: Target: in vitro: Ginkgetin inhibits COX-2 dependent phases of prostaglandin D(2) (PGD(2)) generation in bone marrow-derived mast cells (BMMC) in a… Purity: 98.0% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 10 mg, 50 mg

Ginsenoside C-K Ginsenoside Rb1 (Ginsenoside K; Ginsenoside compound K) Cat. No.: HY-N0904 (Gypenoside III) Cat. No.: HY-N0039

Bioactivity: Ginsenoside C-K, a bacterial metabolite of G-Rb1, exhibits Bioactivity: Ginsenoside Rb1, a main constituent of the root of Panax anti-inflammatory effects by reducing iNOS and COX-2. + + ginseng, inhibits Na , K -ATPase activity with an IC50 of Ginsenoside C-K exhibits an inhibition against the activity of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and CYP2C9 and CYP2A6 in human liver microsomes with IC s of 50 phosphorylation of NF-κB p65 . 32.0±3.6 μM and 63.6±4.2 μM, respectively. Purity: 98.0% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 5 mg, 10 mg

www.MedChemExpress.com 49

Ginsenoside Rb2 Ginsenoside Rb3 (Ginsenoside C) Cat. No.: HY-N0040 (Gypenoside IV) Cat. No.: HY-N0041

Bioactivity: Ginsenoside Rb2 is one of the main bioactive components of Bioactivity: Ginsenoside Rb3 is extracted from steamed Panax notoginseng. ginseng extracts. Rb2 can upregulate GPR120 gene expression. Ginsenoside Rb3 exhibits inhibitory effect on TNFα-induced

NF-κB transcriptional activity with an IC50 of 8.2 μM in 293T cell lines. Ginsenoside Rb3 also inhibits the induction of COX-2 and iNOS mRNA. Purity: 98.26% Purity: 99.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 5 mg, 10 mg 5 mg, 10 mg

Ginsenoside Rc Ginsenoside Rd (Panaxoside Rc) Cat. No.: HY-N0042 (Gypenoside VIII) Cat. No.: HY-N0043

Bioactivity: Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, Bioactivity: Ginsenoside Rd inhibits TNFα-induced NF-κB transcriptional enhances GABA receptor ( GABA )-mediated ion channel A A activity with an IC50 of 12.05±0.82 μM in HepG2 cells.

currents (I GABA). Ginsenoside Rc inhibits the expression of Ginsenoside Rd inhibits expression of COX-2 and iNOS mRNA. TNF-α and IL-1β. Ginsenoside Rd also inhibits Ca2+ influx. Ginsenoside… Purity: 98.0% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 5 mg, 10 mg

Ginsenoside Re (Ginsenoside B2; Panaxoside Re; Ginsenoside Rg1 Chikusetsusaponin IVc; Sanchinoside Re) Cat. No.: HY-N0044 (Panaxoside A; Panaxoside Rg1) Cat. No.: HY-N0045

Bioactivity: Ginsenoside Re is an extract from Panax notoginseng. Ginsenoside Bioactivity: Ginsenoside Rg1 is one of the major active components of Re decreases the β-amyloid protein ( Aβ). Ginsenoside Re ginseng. Ginsenoside Rg1 displays promising effects by plays a role in antiinflammation through inhibition of JNK reducing cerebral Aβ levels. Ginsenoside Rg1 also reduces and NF-κB. NF-κB nuclear translocation.

Purity: 98.09% Purity: 98.0% Clinical Data: Phase 1 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 5 mg, 10 mg

Ginsenoside Rg3 Ginsenoside Rg5 (20(S)-Ginsenoside-Rg3; Rg3; S-Ginsenoside Rg3) Cat. No.: HY-N0603 Cat. No.: HY-N0908

Bioactivity: Ginsenoside Rg3 is the main component of Red ginseng. Bioactivity: Ginsenoside Rg5 is the main component of Red ginseng. Ginsenoside Rg3 inhibits Na+ and hKv1.4 channel with IC Ginsenoside blocks binding of IGF-1 to its receptor with an IC of ~90 nM. Ginsenoside Rg5 also inhibits the mRNA 50s of 32.2±4.5 and 32.6±2.2 μM, respectively. Ginsenoside 50 Rg3 also inhibits Aβ levels, NF-κB activity, and COX-2<… expression of COX-2 via suppression of the DNA binding activities of NF-κB p65. Purity: 98.0% Purity: 99.36% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 5 mg, 10 mg

Ginsenoside Rg6 Ginsenoside Rh1 (Prosapogenin A2; Sanchinoside B2; Cat. No.: HY-N0907 Sanchinoside Rh1; Ginsenoside-Rh1) Cat. No.: HY-N0604

Bioactivity: Ginsenoside Rg6 is the component isolated from notoginseng. Bioactivity: Ginsenoside Rh1 is isolated from the root of Panax Ginseng. Ginsenoside Rg6 inhibits TNF-α-induced NF-κB transcriptional Ginsenoside Rh1 inhibits the expression of PPAR-γ, TNF-α,

activity with an IC50 of 29.34±2.22 μM in HepG2 cells. IL-6, and IL-1β. Ginsenoside Rg6 also exhibits apoptosis-inducing effect.

Purity: >98% Purity: 98.17% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg

50 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Ginsenoside Rh3 Ginsenoside Rk3 Cat. No.: HY-N0606 Cat. No.: HY-N0906

Bioactivity: Ginsenoside Rh3 is a bacterial metabolite of Ginsenoside Rg5. Bioactivity: Ginsenoside Rk3 is present in the roots Panax notoginseng herbs. Ginsenoside Rh3 treatment in human cells induces Nrf2 Ginsenoside Rk3 significantly inhibits TNF-α-induced NF-κB

activation. transcriptional activity, with an IC50 of 14.24±1.30 μM in HepG2 cells

Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg 5 mg, 10 mg

Glafenine hydrochloride (Glafenin) Cat. No.: HY-B1153 (Glafenin hydrochloride) Cat. No.: HY-B1153A

Bioactivity: Glafenine is a non-steroidal anti-inflammatory drug (NSAID), Bioactivity: Glafenine hydrochloride is a non-narcotic analgesic and is a non-narcotic analgesic agent, widely used for the non-steroidal anti-inflammatory drug. It is an ABCG2

treatment of pains of various origins. inhibitor with an IC50 of 3.2 μM.

Purity: >98% Purity: 98.59% Clinical Data: Launched Clinical Data: No Development Reported Size: 100 mg Size: 10mM x 1mL in DMSO, 100 mg

GLPG1690 Glycerol Cat. No.: HY-101772 (Glycerin) Cat. No.: HY-B1659

Bioactivity: GLPG1690 is a first-in-class autotaxin (ATX) inhibitor, with Bioactivity: Glycerol is a clear, colourless, viscous, sweet-tasting liquid. Glycerol is used in sample preparation and gel an IC50 of 131 nM and Ki of 15 nM. formation for polyacrylamide gel electrophoresis.

Purity: 99.80% Purity: 99.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 100mL in 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

GNE-0946 GNE-4997 Cat. No.: HY-19774 Cat. No.: HY-16984

Bioactivity: GNE-0946 is a potent and selective RORγ( RORc) agonist with Bioactivity: GNE-4997 is a potent and selective ITK/TSK inhibitor.

an EC50 value of 4 nM for HEK-293 cell.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 250 mg, 500 mg

GNE-6468 Gp100 (25-33), human Cat. No.: HY-19775 Cat. No.: HY-P1585

Bioactivity: GNE-6468 is a potent and selective RORγ(RORc) with Bioactivity: Gp100 (25-33), human is the 25-33 fragment of the human

an EC50 value of 13 nM for HEK-293 cell. melanoma antigen.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 1 mg, 5 mg, 10 mg

www.MedChemExpress.com 51

GPR84 antagonist 8 GR79236 Cat. No.: HY-112562 Cat. No.: HY-18978

Bioactivity: GPR84 antagonist 8 is a selective GPR84 antagonist. Bioactivity: GR79236 is a highly potent and selective adenosine A1 receptor agonist (Ki = 3.1 nM) that has analgesic and anti-inflammatory actions in humans and animals. IC50 value: 3.1 nM(Ki) Target: adenosine A1 receptor in vitro: GR79236 is a highly potent and selective A1-receptor agonist that is originally developed for… Purity: >98% Purity: 99.98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in Water, 5 mg, 10 mg, 50 mg

GS-9620 GSK 4027 (Vesatolimod) Cat. No.: HY-15601 Cat. No.: HY-101027

Bioactivity: GS-9620 is a potent and selective orally active agonist of Bioactivity: GSK 4027 is a chemical probe for the PCAF/ GCN5 Toll-Like Receptor (TLR)7. bromodomain with an pIC50 of 7.4±0.11 for PCAF in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay.

Purity: 98.78% Purity: 98.01% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

GSK'872 GSK-5498A (GSK872) Cat. No.: HY-101872 Cat. No.: HY-12521

Bioactivity: GSK'872 is a RIPK3 inhibitor, which binds RIP3 kinase domain Bioactivity: GSK-5498A is a selective small molecule blocker of CRAC channel(IC50=1 uM); inhibit mediator release from mast cells, with high affinity ( IC50=1.8 nM,), and inhibits kinase activity ( IC =1.3 nM). and pro-inflammatory cytokine release from T-cells in a 50 variety of species.

Purity: 99.65% Purity: 97.45% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg

GSK-7975A GSK1292263 Cat. No.: HY-12507 Cat. No.: HY-12066

Bioactivity: GSK-7975A is a potent and orally available CRAC channel Bioactivity: GSK1292263 is a novel GPR119 receptor agonist used for the inhibitor. treatment of type 2 diabetes. IC50 value: Target: GPR119 in vitro: GSK-1292263 is selected from 1538 compounds by using Hypo1, the Fit-Value and Estimate of GSK-1292263 that is aligned in Hypo1 are 8.8 and 7.7 (nM), respectively [1]. in… Purity: 99.56% Purity: 98.77% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

GSK2018682 GSK2190915 Cat. No.: HY-19511 (AM-803; Fiboflapon) Cat. No.: HY-15874

Bioactivity: GSK2018682 is an agonist for S1P1 and S1P5 receptor with Bioactivity: GSK2190915(AM-803; Fiboflapon) is a potent

pEC50s of 7.7 and 7.2, respectively, and has no agonist FLAP(5-Lipoxygenase-activating protein) inhibitor with binding activity towards human S1P2, S1P3, or S1P4. GSK2018682 is used IC50 of 2.9 nM. in the research of .

Purity: >98% Purity: 98.18% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg

52 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

GSK2190915 sodium salt GSK2239633A (GSK-2190915A; Fiboflapon sodium; AM-803 sodium) Cat. No.: HY-15874A Cat. No.: HY-100183

Bioactivity: GSK2190915(AM-803; Fiboflapon) sodium salt is a potent Bioactivity: GSK2239633A is a CC-chemokine receptor 4 ( CCR4) antagonist, FLAP(5-Lipoxygenase-activating protein) inhibitor with binding which inhibits the binding of [ 125I]-TARC to human CCR4 with a IC50 of 2.9 nM. pIC50 of 7.96±0.11.

Purity: 99.08% Purity: 98.05% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 1 mg, 5 mg, 10 mg

GSK256066 GSK256066 2,2,2-trifluoroacetic acid Cat. No.: HY-10469 (GSK 256066) Cat. No.: HY-70069

Bioactivity: GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) Bioactivity: GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7. PDE4B versus PDE7.

Purity: 98.11% Purity: 98.94% Clinical Data: Phase 2 Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg

GSK2981278 GSK2982772 Cat. No.: HY-19770 Cat. No.: HY-101760

Bioactivity: GSK2981278 is a retinoid-related gamma (RORy) Bioactivity: GSK2982772 is a potent and ATP competitive RIP1 inhibitor with modulator, extracted from patent WO/2015061515 A1, example an IC50 of 16 nM. 124.

Purity: 99.77% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

GSK4028 GSK484 Cat. No.: HY-101027A (GTPL8577; AOB6992) Cat. No.: HY-100514

Bioactivity: GSK4028 is the enantiomeric negative control of GSK4027, which Bioactivity: GSK484 is a peptidylarginine deiminase 4 ( PAD4) inhibitor. is a PCAF/GCN5 bromodomain chemical probe, the pIC of 50 GSK484 demonstrates high affinity binding to PAD4 with IC50s GSK4028 is 4.9 in a time-resolved fluorescence resonance of 50 nM in the absence of Calcium. In the presence of 2 mM energy transfer (TR-FRET) assay. Calcium, notably lower potency (250 nM) is observed.

Purity: >98% Purity: 98.00% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

GSK682753A GTS-21 dihydrochloride Cat. No.: HY-101192 (DMXB-A; DMBX-anabaseine) Cat. No.: HY-14564A

Bioactivity: GSK682753A is a selective and highly potent inverse agonist of Bioactivity: GTS-21 dihydrochloride is a selective α7 nicotinic

the epstein-barr virus-induced receptor 2 ( EBI2) with an IC50 acetylcholine receptor agonist, has recently been established of 53.6 nM. as a promising treatment for inflammation.

Purity: 98.47% Purity: 99.76% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

www.MedChemExpress.com 53

Guacetisal GW 766994 Cat. No.: HY-17477 (GW 994) Cat. No.: HY-107051

Bioactivity: is obtained from the esterification of Bioactivity: GW 766994 is a specific and oral chemokine receptor-3 acetylsalicylic acid with which can be used to treat (CCR3) antagonist, which has entered clinical trial for chronic bronchitis extracted from patent CN 106866420 A. asthma and eosinophilic bronchitis.

Purity: 99.95% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

GW-870086 GW0742 Cat. No.: HY-103662 (GW610742) Cat. No.: HY-13928

Bioactivity: GW-870086 is a potent anti-inflammatory agent, acting as a Bioactivity: GW0742 is a high affinity PPAR β/δ agonist with an IC50 of 1 glucocorticoid receptor agonist, with a pIC50 of 10.1 in A549 nM for human PPARδ, and EC50s of 1 nM, 1.1 μM and 2 μM for cells expressing NF-κB. human PPARδ, PPARα, and PPARγ, respectively.

Purity: >98% Purity: 99.63% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

GW2580 GW274150 Cat. No.: HY-10917 Cat. No.: HY-12119

Bioactivity: GW2580 is an orally bioavailable inhibitor of c-Fms kinase Bioactivity: GW274150 is a novel arginine-competitive, NADPH-dependent iNOS which completely inhibits human cFMS kinase in vitro at 0.06 μM. inhibitor that has been identified from a series of acetamide amino acids that have a high selectivity for iNOS vs both eNOS (> 260-fold) and nNOS (> 219-fold) and high (> 90%) after oral administration. Target:… Purity: 98.45% Purity: 99.84% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g 1 mg, 5 mg, 10 mg, 50 mg

GW311616 GW311616 hydrochloride Cat. No.: HY-15891 (GW311616A) Cat. No.: HY-15891A

Bioactivity: GW311616 is a potent, intracellular, orally bioavailable, long Bioactivity: GW311616A(GW311616 Hcl) is a potent, intracellular, orally duration inhibitor of human neutrophil elastase(HNE) with IC50 bioavailable, long duration inhibitor of human neutrophil of 22 nM; free base form of GW311616A. elastase(HNE) with IC50 of 22 nM. IC50 value: 22 nM [1] Target: neutrophil elastase The HNE inhibitor GW311616A is selective over other human serine proteases (IC50 values… Purity: 99.30% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

GW4869 GW627368 Cat. No.: HY-19363 Cat. No.: HY-16963

Bioactivity: GW4869 is a noncompetitive neutral sphingomyelinase Bioactivity: GW627368(GW627368X) is a novel, potent and selective

inhibitor with an IC50 of 1 μM. competitive antagonist of EP4 receptor(Ki= 100 nM) with additional human TP receptor affinity(Ki= 150 nM).

Purity: 96.35% Purity: 99.88% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg

54 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

GW842166X H3R-IN-1 Hydrochloride Cat. No.: HY-14167 Cat. No.: HY-112219A

Bioactivity: GW842166X is a potent and selective 2 Bioactivity: H3R-IN-1 Hydrochloride is a histamine receptor 3 ( H3R)

(CB2) agonist with IC50 values of 63 and 91 nM for human and inverse agonist extracted from patent WO2013107336A1, compound rat CB2, respectively. example 2.

Purity: 99.97% Purity: 95.52% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 25 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

HA Peptide Halofuginone Cat. No.: HY-P0239 (Tempostatin; RU-19110) Cat. No.: HY-N1584

Bioactivity: HA Peptide (HA tag) is a nine amino acids peptide derived from Bioactivity: Halofuginone is a plant derivative that has been shown to the human influenza hemagglutinin (HA). It is extensively used inhibit Th17 differentiation, and recently tested as a to isolate, purify, detect, and track the protein of interest potential immunosuppressant. in cell biology and biochemistry. Sequence: Tyr-Pro-Tyr-Asp-Val-Pro-Asp-Tyr-Ala. Purity: 99.40% Purity: 97.46% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Handle region peptide, rat Heparan Sulfate Cat. No.: HY-P1572 Cat. No.: HY-101916

Bioactivity: Handle region peptide, rat is a prorenin receptor antagonist, Bioactivity: Heparan sulfate, a complex and linear polysaccharide, exists suppresses the progression of diabetic nephropathy and has as part of glycoproteins named heparan sulfate proteoglycans, anti-inflammatory in the eye. which are expressed abundantly on the cell surface and in the extracellular matrix.

Purity: >98% Purity: Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg, 25 mg

Heterocyclyl derivative 1 HG-9-91-01 Cat. No.: HY-101831 (SIK inhibitor 1) Cat. No.: HY-15776

Bioactivity: Heterocyclyl carbamate derivative 1 is a heterocyclyl Bioactivity: HG-9-91-01 is a potent and highly selective salt-inducible

carbamate derivative that may be used for the research of kinase ( SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 inflammatory and neurological diseases. nM for SIK1, SIK2 and SIK3 respectively.

Purity: >98% Purity: 98.17% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

Hispidol Histatin 5 ((Z)-Hispidol) Cat. No.: HY-102040 Cat. No.: HY-P0273

Bioactivity: Hispidol ((Z)-Hispidol) is a potential therapeutic for Bioactivity: Histatin 5 inhibits the activity of the host matrix

inflammatory bowel disease; inhibits TNF-α induced adhesion metalloproteinases MMP-2 and MMP-9 with IC 50s of 0.57 and of monocytes to colon epithelial cells with an IC50 of 0.50 0.25 μM, respectively. Sequence: Asp-Ser-His-Ala-Lys-Arg-His-H µM. is-Gly-Tyr-Lys-Arg-Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Gly -Tyr. Purity: 98.57% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 500u g, 1 mg, 5 mg, 10 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg

www.MedChemExpress.com 55

Homoplantaginin Hosenkoside A Cat. No.: HY-N1949 Cat. No.: HY-N2249

Bioactivity: Homoplantaginin is a flavonoid from a traditional Chinese Bioactivity: Hosenkoside A is a baccharane glycoside isolated from the medicine Salvia plebeia with antiinflammatory and antioxidant seeds of impatiens balsamina. properties. Homoplantaginin could inhibit TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation.

Purity: 99.81% Purity: 99.65% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg 5 mg

Hosenkoside B Hosenkoside F Cat. No.: HY-N2250 ((+)-Hosenkoside F) Cat. No.: HY-N2241

Bioactivity: Hosenkoside B is a baccharane glycoside isolated from the Bioactivity: Hosenkoside F is a baccharane glycoside isolated from the seeds of impatiens balsamina. seeds of impatiens balsamina.

Purity: 96.23% Purity: 98.39% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg 5 mg

Hosenkoside K Hosenkoside M Cat. No.: HY-N2243 ((+)-Hosenkoside M) Cat. No.: HY-N2244

Bioactivity: Hosenkoside K is a baccharane glycoside isolated from the Bioactivity: Hosenkoside M is a baccharane glycoside isolated from the seeds of impatiens balsamina. seeds of impatiens balsamina.

Purity: 99.29% Purity: 99.71% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg 5 mg

HPGDS inhibitor 1 hPGDS-IN-1 Cat. No.: HY-10439 Cat. No.: HY-12791

Bioactivity: HPGDS inhibitor 1 is a novel and selective Hematopoietic Bioactivity: hPGDS-IN-1 is a hPGDS inhibitor ,with IC50 of 12 nM in the Prostaglandin D Synthase (HPGDS) inhibitor with an IC50 Value Fluorescence Polarization Assay or the EIA assay. of 0.7 nM.

Purity: 99.49% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg

HSR6071 Cat. No.: HY-U00133 (Cortisol) Cat. No.: HY-N0583

Bioactivity: HSR6071 is an antiallergic agent with potential for the Bioactivity: Hydrocortisone is a steroid hormone or glucocorticoid secreted treatment of asthma. by the adrenal cortex.

Purity: >98% Purity: 99.66% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 1 g, 5 g

56 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Hydrocortisone 17-butyrate (Cortisol 17-butyrate; ) Cat. No.: HY-B0983 (Hydrocortisone 21-acetate) Cat. No.: HY-B1183

Bioactivity: Hydrocortisone 17-butyrate is an adrenocortico hormone. Bioactivity: Hydrocortisone acetate is a corticosteroid, used to decrease swelling, itching, and pain that is caused by minor skin irritations or by hemorrhoids.

Purity: >98% Purity: 99.23% Clinical Data: Launched Clinical Data: Launched Size: 200 mg, 500 mg Size: 10mM x 1mL in DMSO, 100 mg

Hydrocortisone cypionate Hydroxyfasudil Cat. No.: HY-U00089 (HA-1100) Cat. No.: HY-13911

Bioactivity: is a synthetic glucocorticoid Bioactivity: Hydroxyfasudil is a ROCK inhibitor, with IC50s of 0.73 and corticosteroid and a corticosteroid ester. 0.72 μM for ROCK1 and ROCK2, respectively.

Purity: >98% Purity: 98.13% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg

Hydroxyfasudil hydrochloride (HA-1100 hydrochloride; HA 1100 Hydroxyzine hydrochloride; HA1100 hydrochloride) Cat. No.: HY-13911A Cat. No.: HY-B0548

Bioactivity: Hydroxyfasudil hydrochloride is a ROCK inhibitor, with IC50s Bioactivity: Hydroxyzine is a histamine H1-receptor antagonist. of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively.

Purity: 99.40% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 100 mg, 500 mg 5 mg, 10 mg, 50 mg

Hydroxyzine dihydrochloride Hydroxyzine pamoate Cat. No.: HY-B0548A Cat. No.: HY-B0895

Bioactivity: Hydroxyzine Dihydrochloride is a histamine H1-receptor Bioactivity: Hydroxyzine pamoate is a histamine H1-receptor antagonist. antagonist. Target: Histamine H1-Receptor Hydroxyzine inhibits Target: Histamine H1-Receptor Hydroxyzine inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for and by 17% 0.1 μM in pretreated bladder slices for 60 min [1]. 60 min [1]. Hydroxyzine (0.1 mM) treatment inhibits the… Hydroxyzine (0.1 mM) treatment inhibits the progression and… Purity: 99.96% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in Water, Size: 100 mg 100 mg, 500 mg

Hypaconitine Iberdomide Cat. No.: HY-N0267 (CC-220) Cat. No.: HY-101291

Bioactivity: Hypaconitine, an active and highly toxic constituent derived Bioactivity: Iberdomide (CC-220) is a cereblon modulator with an IC50 of 60 from Aconitum species, is widely used to treat rheumatism. nM.

Purity: 98.0% Purity: 98.90% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

www.MedChemExpress.com 57

IBMX (3-Isobutyl-1-methylxanthine; Isobutylmethylxanthine) Cat. No.: HY-12318 (KC-404; AV-411; MN-166) Cat. No.: HY-B0763

Bioactivity: IBMX is a broad-spectrum phosphodiesterase ( PDE) inhibitor, Bioactivity: Ibudilast(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor which has been marketed for with IC50s of 6.5, 26.3 and 31.7 μM for PDE3, PDE4 and PDE5, respectively. treating asthma.

Purity: 99.99% Purity: 99.89% Clinical Data: Phase 2 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg 10 mg, 50 mg, 100 mg

Ibuprofen piconol Icariin (U75630) Cat. No.: HY-101482 (Ieariline) Cat. No.: HY-N0014

Bioactivity: Ibuprofen piconol is a non-steroidal, anti-inflammatory Bioactivity: Icariin is a flavonol glycoside. Icariin inhibits PDE5 and (NSAID) drug marketed in Japan for the topical relief of PDE4 activities with IC50s of 432 nM and 73.50 μM, primary thermal burns and . respectively. Icariin also is a PPARα activator.

Purity: 98.0% Purity: 98.0% Clinical Data: Launched Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg 100 mg, 200 mg, 500 mg

ICI 211965 IDE1 (ZM-211965) Cat. No.: HY-100148 Cat. No.: HY-100533

Bioactivity: ICI 211965 is a selective and orally potent 5-Lipoxygenase ( Bioactivity: IDE1 is an inducer of definitive endoderm 1 (IDE1). 5-LPO) inhibitor.

Purity: >98% Purity: 98.01% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg

IFN alpha-IFNAR-IN-1 IFN alpha-IFNAR-IN-1 hydrochloride (IFN-alpha and IFNAR interaction inhibitor) Cat. No.: HY-12836 (IFN-alpha and IFNAR interaction inhibitor) Cat. No.: HY-12836A

Bioactivity: IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight Bioactivity: IFN alpha-IFNAR-IN-1 hydrochloride is a nonpeptidic, inhibitor of the interaction between IFN-α and IFNAR; inhibit low-molecular-weight inhibitor of the interaction between MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 uM). IFN-α and IFNAR; inhibit MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 uM).

Purity: >98% Purity: 96.75% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg, 100 mg Size: 5 mg, 10 mg, 50 mg, 100 mg

Iguratimod IKarisoside A (T614) Cat. No.: HY-17009 (Icarisoside-A; Baohuoside II) Cat. No.: HY-N0875

Bioactivity: Iguratimod is an antirheumatic agent, acts as an inhibitor of Bioactivity: IKarisoside A(Icarisoside-A) is a natural compound isolated

COX-2, with an IC50 of 20 μM (7.7 μg/mL), but shows no effect from Epimedium koreanum (Berberidaceae); has anti-inflammatory on COX-1. Iguratimod also inhibits migration properties.

inhibitory factor ( MIF) with an IC50 of 6.81 μM. Purity: 99.85% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg 5 mg, 10 mg, 50 mg

58 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

IKK 16 IKK-3 Inhibitor Cat. No.: HY-13687 Cat. No.: HY-14682

Bioactivity: IKK 16 is a selective IκB kinase ( IKK) inhibitor for IKK2, IKK Bioactivity: IKK-3 Inhibitor is a dual inhibitor of TBK1 and IKKε with

complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, IC50s of 93 nM and 469 nM, respectively. IKK-3 Inhibitor also

respectively. IKK16 also inhibits -rich repeat kinase-2 inhibits IKK2 with an IC50 of 790 nM. ( LRRK2) with an IC50 of 50 nM. Purity: 99.78% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg 10 mg, 50 mg

IKK-IN-1 IL-17A antagonist 1 Cat. No.: HY-13873 Cat. No.: HY-101913

Bioactivity: IKK-IN-1 is an inhibitor of IKK extracted from patent Bioactivity: IL-17A antagonist 1 is an IL-17A antagonist. WO2002024679A1, compound example 18-13.

Purity: 95.04% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 1 mg, 5 mg, 10 mg

IL-17A antagonist 3 Imidazol-1-yl compound 1 Cat. No.: HY-101915 Cat. No.: HY-U00322

Bioactivity: IL-17A antagonist 3 is an IL-17A antagonist. Bioactivity: Imidazol-1-yl compound 1 is a compound which can be used to treat gastro intestinal functional disorders in the lower intestinal tracts extracted from patent DE 4238553 A1.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

Imiquimod Imiquimod hydrochloride (R 837) Cat. No.: HY-B0180 (R 837 hydrochloride) Cat. No.: HY-B0180A

Bioactivity: Imiquimod is an immune response modifier and a toll-like Bioactivity: Imiquimod hydrochloride is an immune response modifier that receptor 7 agonist. acts as a toll-like receptor 7agonist.

Purity: 99.57% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 100 mg, 200 mg, 500 mg 100 mg, 200 mg, 500 mg

Imiquimod maleate INCB 024360 (R 837 maleate) Cat. No.: HY-B0180B (Epacadostat) Cat. No.: HY-15689

Bioactivity: Imiquimod maleate is an immune response modifier that acts as Bioactivity: INCB 024360 is a potent and selective indoleamine

a toll-like receptor 7agonist. 2,3-dioxigenase 1 (IDO1) inhibitor with an IC50 of 71.8 nM.

Purity: >98% Purity: 99.65% Clinical Data: Launched Clinical Data: Phase 3 Size: 100 mg, 200 mg, 500 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g, 2 g

www.MedChemExpress.com 59

INCB3344 Cat. No.: HY-50674 (MK-639; L-735524) Cat. No.: HY-B0689

Bioactivity: INCB3344 is a potent, selective and orally bioavailable CCR2 Bioactivity: Indinavir(MK-639; L735524) is a potent and specific HIV protease inhibitor that appears to have good oral antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM bioavailability. Target: HIV Protease Indinavir(MK-639) is a (mCCR2) in antagonism of chemotaxis activity. protease inhibitor used as a component of highly active antiretroviral therapy (HAART) to treat HIV infection and… Purity: 99.76% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

Indinavir sulfate Indomethacin (MK-639 sulfate; L735524 sulfate) Cat. No.: HY-B0689A (Indometacin) Cat. No.: HY-14397

Bioactivity: Indinavir sulfate(MK-639 sulfate; L735524 sulfate ) is a Bioactivity: Indomethacin is a potent and nonselective inhibitor of COX1 potent and specific HIV protease inhibitor that appears to and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and have good oral bioavailability. Target: HIV Protease COX-2, respectively, in CHO cells. Indinavir(MK-639) is a protease inhibitor used as a component of highly active antiretroviral therapy (HAART) to treat HIV… Purity: 99.50% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg 1 g, 5 g

Indoprofen INF39 ((±)-Indoprofe) Cat. No.: HY-B1104 Cat. No.: HY-101868

Bioactivity: is a non-steroidal anti-inflammatory drug, provide Bioactivity: INF39 is an irreversible and noncytotoxic NLRP3 inhibitor. insight into treatments for spinal muscular atrophies.

Purity: 99.58% Purity: 99.61% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Ingenol Mebutate INO5042 (Ingenol 3-angelate; PEP005) Cat. No.: HY-B0719 Cat. No.: HY-U00094

Bioactivity: Ingenol Mebutate is an active ingredient in Euphorbia peplus, Bioactivity: INO5042 is an anti-inflammatory agent.

acts as a potent PKC modulator, with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has antiinflammatory and antitumor activity. Purity: 98.74% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 1 mg, 5 mg, 10 mg

Interferon receptor agonist IPI-3063 Cat. No.: HY-112189 Cat. No.: HY-111510

Bioactivity: Interferon receptor agonist is an interferonm (IFN) receptor Bioactivity: IPI-3063 is a potent and selective PI3K p110δ inhibitor with

agonist. an IC50 of 2.5±1.2 nM.

Purity: >98% Purity: 98.80% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 25 mg

60 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Ipsalazide IQ-1 Cat. No.: HY-101744 (IQ-1S (free acid)) Cat. No.: HY-100233

Bioactivity: Ipsalazide is a novel sulfasalazine analog designed to release Bioactivity: IQ-1 is a prospective inhibitor of NF-κB/activating protein 1 ( 5-aminosalicylic acid and a nontoxic carrier molecule in the AP-1) activity with an IC50 of 2.3±0.41 μM. IQ-1 has binding gastrointestinal tract. affinity (K d values) in the nanomolar range for all three

JNKs with Kds of 100 nM, 240 nM, and 360 nM for JNK3 Purity: >98% Purity: 98.71% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

IRAK inhibitor 1 IRAK inhibitor 2 Cat. No.: HY-13275 Cat. No.: HY-13276

Bioactivity: IRAK inhibitor 1 is a potent IRAK-4 inhibitor with IC50 of 216 Bioactivity: IRAK inhibitor 2 is interleukin-1 receptor associated kinase inhibitor . nM, is poorly active against JNK-1 and JNK-2 with IC50 of 3.801 μM, and >10 μM, respectively.

Purity: 99.47% Purity: 97.23% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg

IRAK inhibitor 3 IRAK inhibitor 4 Cat. No.: HY-13277 Cat. No.: HY-13278

Bioactivity: IRAK inhibitor 3 is an interleukin-1 (IL-I) Bioactivity: IRAK inhibitor 4 is an interleukin-1 receptor associated receptor-associated kinase ( IRAK) kinase modulator extracted kinase 4( IRAK4) inhibitor. from patent WO2008030579 A2.

Purity: 96.20% Purity: 98.05% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg

IRAK inhibitor 4 trans IRAK inhibitor 6 Cat. No.: HY-13278A Cat. No.: HY-13280

Bioactivity: IRAK inhibitor 4 (trans) is the trans form of IRAK inhibitor Bioactivity: IRAK inhibitor 6 is an inhibitor of interleukin-1 receptor 4. IRAK inhibitor 4 is an interleukin-1 receptor associated associated kinase 4 (IRAK-4) with IC50 of 160 nM. kinase 4 ( IRAK4) inhibitor.

Purity: 99.50% Purity: 99.70% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg 5 mg, 10 mg, 50 mg

IRAK-1-4 Inhibitor I IRAK4-IN-1 (IRAK-1/4 Inhibitor I) Cat. No.: HY-13329 Cat. No.: HY-101922

Bioactivity: IRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 Bioactivity: IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (

receptor-associated kinase 1/4 ( IRAK 1/4) with IC50s of 0.2 IRAK4) inhibitor with an IC50 of 7 nM. μM and 0.3 μM, respectively.

Purity: 98.49% Purity: 99.01% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

www.MedChemExpress.com 61

Iralukast Irsogladine (CGP 45715A) Cat. No.: HY-101944 (Dicloguamine) Cat. No.: HY-B0327

Bioactivity: Iralukast is a cysteinyl-leukotriene antagonist ( CysLT) with Bioactivity: Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder. a pK i of 7.8 for CysLT1.

Purity: >98% Purity: 95.13% Clinical Data: No Development Reported Clinical Data: Launched Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 100 mg, 500 mg

Irsogladine maleate ISCK03 (Dicloguamine maleate; MN1695) Cat. No.: HY-B0327A Cat. No.: HY-101443

Bioactivity: Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine Bioactivity: ISCK03 is a specific SCF/c-Kit inhibitor. receptor binder.

Purity: >98% Purity: 98.82% Clinical Data: Launched Clinical Data: No Development Reported Size: 100 mg, 500 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

ISO-1 Isoorientin (MIF Antagonist) Cat. No.: HY-16692 (Homoorientin) Cat. No.: HY-N0767

Bioactivity: ISO-1 is a macrophage migration inhibitory factor ( MIF) Bioactivity: Isoorientin is a potent inhibitor of COX-2 with an IC50 value antagonist with an IC of 7 μM. 50 of 39 μM.

Purity: 98.0% Purity: 99.24% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 1 mg, 5 mg, 10 mg, 25 mg, 50 mg

Isoquercitrin Isorhamnetin (Isoquercitroside; Isoquercetin) Cat. No.: HY-N0768 (3'-Methylquercetin) Cat. No.: HY-N0776

Bioactivity: Isoquercitrin is an effective antioxidant and an eosinophilic Bioactivity: Isorhamnetin is a flavonoid compound extracted from the inflammation suppressor. Chinese herb Hippophae rhamnoides L.. Isorhamnetin suppresses through direct inhibition of MEK1 and PI3K.

Purity: 99.97% Purity: 98.00% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg

Isovitexin IT1t (Saponaretin; Homovitexin) Cat. No.: HY-N0773 Cat. No.: HY-101458

Bioactivity: Isovitexin is a flavonoid isolated from rice hulls of Oryza Bioactivity: IT1t is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4

sativa, possesses anti-inflammatory and anti-oxidant interaction with an IC50 of 2.1 nM. activities; Isovitexin acts like a JNK1/2 inhibitor and inhibits the activation of NF-κB.

Purity: 98.94% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg

62 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

IT1t dihydrochloride Itch-Targeting Compound 1 Cat. No.: HY-101458A Cat. No.: HY-U00361

Bioactivity: IT1t dihydrochloride is a potent CXCR4 antagonist; inhibits Bioactivity: Itch-Targeting Compound 1 is an anti-itching agent.

CXCL12/CXCR4 interaction with an IC50 of 2.1 nM.

Purity: 98.09% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

ITE ITK inhibitor Cat. No.: HY-19317 Cat. No.: HY-11066

Bioactivity: ITE is a potent endogenous agonist of aryl hydrocarbon Bioactivity: ITK inhibitor is a potent ITK inhibitor.

receptor ( AhR), binding directly to AHR, with a Ki of 3 nM. ITE also has immunosuppressive activity.

Purity: 98.0% Purity: 97.28% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg

IX 207-887 JAK inhibitor 1 Cat. No.: HY-106087 Cat. No.: HY-111471

Bioactivity: IX 207-887 is a novel antiarthritic agent which inhibits the Bioactivity: JAK inhibitor 1 is an inhibitor of JAK extracted from patent release of interleukin-1 ( IL-1). US20170121327A1, compound example 283.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 250 mg, 500 mg

JAK-IN-1 JAK3-IN-6 Cat. No.: HY-13827 Cat. No.: HY-101976

Bioactivity: JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and Bioactivity: JAK3-IN-6 is a potent, selective irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC of 0.15 nM. 3.2 nM, respectively. JAK-IN-1 shows improved selectivity for 50 JAK3 over JAK1.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 250 mg, 500 mg

JNJ-42041935 JNJ-7777120 Cat. No.: HY-12832 Cat. No.: HY-13508

Bioactivity: JNJ-42041935 is a potent, competitive and selective inhibitor Bioactivity: JNJ-7777120 is a selective H4R antagonist with Ki of 4 ±1 nM, of prolyl hydroxylase PHD; inhibits PHD1, PHD2, and PHD3 with exhibits >1000-fold selectivity over the other histamin

pKi values of 7.91±0.04, 7.29 ±0.05, and 7.65±0.09, receptors. respectively.

Purity: 99.79% Purity: 98.13% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 5 mg, 10 mg, 50 mg, 100 mg

www.MedChemExpress.com 63

JTE522 K-7174 (JTP19605; RWJ57504; ) Cat. No.: HY-U00197 Cat. No.: HY-12743

Bioactivity: JTE522 is a highly selective, time-dependent and irreversible Bioactivity: K-7174 is a novel cell adhesion inhibitor; inhibits the

human COX-2 inhibitor with an IC50 of 85 nM in an enzyme expression of vascular cell adhesion molecule-1 (VCAM-1) assay. induced by either IL-1β or TNF-α.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 5 mg, 10 mg, 50 mg

K-7174 dihydrochloride KCA 757 Cat. No.: HY-12743A (MN 001; Tipelukast) Cat. No.: HY-14938

Bioactivity: K-7174 dihydrochloride is a novel cell adhesion inhibitor; Bioactivity: KCA 757 is a sulfidopeptide antagonist, inhibits the expression of vascular cell adhesion molecule-1 an orally bioavailable anti-inflammatory agent and used for (VCAM-1) induced by either IL-1β or TNF-α. the treatment of asthma.

Purity: 99.63% Purity: >98% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in Water, Size: 1 mg 5 mg, 10 mg, 50 mg

Ketoprofen Cat. No.: HY-B0227 (RS37619) Cat. No.: HY-B0580

Bioactivity: is a non-steroidal antiinflammatory agent, acting Bioactivity: Ketorolac is a non-steroidal anti-inflammatory agent, acting

as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM as a nonselective COX inhibitor, with IC50s of 20 nM for for COX-1 and COX-2 in human blood monocytes, respectively. COX-1 and 120 nM for COX-2.

Purity: 99.69% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 100 mg, 500 mg 1 g, 5 g

Ketorolac tromethamine salt fumarate (Ketorolac tris salt; Ketorolac Tromethamine) Cat. No.: HY-B0138 (HC 20511 fumarate) Cat. No.: HY-B0157A

Bioactivity: Ketorolac tromethamine salt is a non-steroidal Bioactivity: Ketotifen (fumarate) is a second-generation noncompetitive anti-inflammatory agent, acting as a nonselective COX H1-antihistamine and , which is used to

inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. prevent asthma attacks.

Purity: 99.79% Purity: 99.92% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g 200 mg, 1 g

KG-501 Ki20227 (Naphthol AS-E phosphate) Cat. No.: HY-103299 Cat. No.: HY-10408

Bioactivity: KG-501 is a CREB inhibitor, with an IC50 of 6.89 μM. Bioactivity: Ki-20227 is a highly selective c-Fms tyrosine kinase(CSF1R) inhibitor with IC50 value of 2 nM; 6 fold and > 100 fold selectivity over VEGFR2(IC50=12 nM) and c-Kit/PDGFRβ(IC50=451/217 nM), respectively. IC50 value: Target: CSF1R in vitro: Ki20227 did not inhibit other kinases… Purity: 99.12% Purity: 99.30% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 2 mg, 5 mg, 10 mg, 50 mg

64 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

KI696 Kif15-IN-1 Cat. No.: HY-101140 Cat. No.: HY-15948

Bioactivity: KI696 is a high affinity probe that disrupts the Keap1/NRF2 Bioactivity: Kif15-IN-1 is an inhibitor of the mitotic kinesin Kif15, and is interaction. used for the research of cellular proliferative diseases.

Purity: 99.25% Purity: 99.04% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

Kif15-IN-2 KIN1148 Cat. No.: HY-15949 Cat. No.: HY-101950

Bioactivity: Kif15-IN-2 is an inhibitor of the mitotic kinesin Kif15, and is Bioactivity: KIN1148, a small-molecule IRF3 agonist, is a novel influenza used for the research of cellular proliferative diseases. adjuvant found to enhance flu vaccine efficacy.

Purity: 96.51% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

KIRA6 KP136 Cat. No.: HY-19708 (AL136) Cat. No.: HY-U00168

Bioactivity: KIRA6 allosterically inhibits IRE1α RNase kinase activity with Bioactivity: KP136 is an orally effective antiallergic agent. The IC50 is an IC of 0.6 µM. 50 76.1 μg/mL for histamine release and 63 ug/mL for degranulation.

Purity: 98.75% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 1 mg, 5 mg, 10 mg

KP496 KRN2 Cat. No.: HY-U00253 Cat. No.: HY-112125

Bioactivity: KP496 is a selective, dual antagonist for Leukotriene D4 Bioactivity: KRN2 is a selective inhibitor of nuclear factor of activated T

receptor and receptor. cells (NFAT5), with an IC50 of 0.1 μM.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

KRN2 bromide Kuwanon A Cat. No.: HY-112125A Cat. No.: HY-N2300

Bioactivity: KRN2 is a selective inhibitor of nuclear factor of activated T Bioactivity: Kuwanon A is a flavone derivative isolated from the root barks

cells (NFAT5), with an IC50 of 0.1 μM. of the mulberry tree ( Morus alba L.); inhibits production with an IC50 of 10.5 μM.

Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 2 mg, 5 mg, 10 mg, 25 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

www.MedChemExpress.com 65

KY-556 Kynurenic acid (N556) Cat. No.: HY-U00148 (Quinurenic acid) Cat. No.: HY-100806

Bioactivity: KY-556 is a promising and orally-active pro-drug of disodium Bioactivity: Kynurenic acid, an endogenous metabolite, is a cromoglycate (DSCG) against allergic diseases. broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also a selective ligand of the GPR35 receptor.

Purity: >98% Purity: 98.75% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 100 mg, 500 mg

Kynurenic acid sodium KZR-504 Cat. No.: HY-107512 Cat. No.: HY-101786

Bioactivity: Kynurenic acid, an endogenous tryptophan metabolite, is a Bioactivity: KZR-504 is a highly selective and orally active inhibitor of broad-spectrum antagonist targeting NMDA, glutamate, immunoproteasome low molecular mass polypeptide 2 (LMP2),

α7 nicotinic acetylcholine receptor. Kynurenic acid is also a with IC50s of 51 nM, 4.274 μM for LMP2 and LMP7, respectively. selective ligand of the GPR35 receptor.

Purity: 98.60% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 100 mg

L 601920-0 L 888607 (Methyl-3β-hydroxycholenate; NSC 84140) Cat. No.: HY-100084 Cat. No.: HY-111271

Bioactivity: L 601920-0 is a ROR gamma modulator extracted from patent Bioactivity: L 888607 is a potent, and selective CRTH2 (also known as DP

US20110263046 A1, in figure 2. 2) agonist with a Ki of 0.8±0.4 nM.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

L 888607 Racemate L-689502 Cat. No.: HY-111271A Cat. No.: HY-U00261

Bioactivity: L 888607 Racemate is a selective prostaglandin D 2 receptor Bioactivity: L-689502 is a potent inhibitor of HIV-l protease with an IC50

subtype 1 (DP1) antagonist, with Kis of 132 nM and 17 nM for of 1 nM. DP1 and thromboxane A2 receptor (TP), respectively.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

L-745337 L-Cysteine methyl ester hydrochloride (Thioflosulide) Cat. No.: HY-19217 Cat. No.: HY-B1038

Bioactivity: L-745337 is a selective cyclooxygenase-2 (COX2) inhibitor with Bioactivity: Mecysteine hydrochloride is an antitussive, and an expectorant anti-inflammatory activities. agent, used to relieve breathing difficulties caused by mucus.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 1 g

66 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

L-Glutathione reduced L-Hisidine (GSH; γ-L-Glutamyl-L-cysteinyl-glycine) Cat. No.: HY-D0187 Cat. No.: HY-N0832

Bioactivity: L- reduced (GSH; γ-L-Glutamyl-L-cysteinyl-glycine) Bioactivity: L-Hisidine is an essential amino acid for infants. L-Hisidine is an endogenous antioxidant and is capable of scavenging is an inhibitor of mitochondrial glutamine transport. oxygen-derived free radicals.

Purity: 99.64% Purity: 99.94% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 g, 5 g Size: 10mM x 1mL in Water, 1 g

L-Homocystine L-Kynurenine Cat. No.: HY-W011690 Cat. No.: HY-104026

Bioactivity: L-Homocystine is the oxidized member of the L-homocysteine. Bioactivity: L-Kynurenine is a metabolite of the amino acid L-tryptophan. Homocysteine is a pro-thrombotic factor, vasodilation L-Kynurenine is an aryl hydrocarbon receptor agonist. impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms. Purity: 98.0% Purity: 99.40% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 50 mg

L-Lysine hydrochloride L-NIL Cat. No.: HY-N0470 Cat. No.: HY-12116

Bioactivity: L-lysine hydrochloride is an essential amino acid for humans Bioactivity: L-NIL is a potent and selective inhibitor of inducible NO with various benefits including treating herpes, increasing synthase with IC50s of 3.3 and 92 μM for mouse inducible NO calcium absorption, reducing diabetes-related illnesses and synthase and rat brain constitutive NO synthase, respectively. improving gut health.

Purity: 98.0% Purity: 99.26% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 g 50 mg, 100 mg

L-Valyl-L-phenylalanine Lansoprazole (Valylphenylalanine; H-VAL-PHE-OH) Cat. No.: HY-107378 (AG-1749) Cat. No.: HY-13662

Bioactivity: L-Valyl-L-phenylalanine (Valylphenylalanine; H-VAL-PHE-OH) has Bioactivity: Lansoprazole(AG 1749) is a proton pump inhibitor which been reported as biocompatible polymer. prevents the stomach from producing acid.

Purity: 99.72% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg 1 g, 5 g

Lansoprazole sodium (AG-1749 sodium) Cat. No.: HY-13662A (ABR-215062) Cat. No.: HY-13010

Bioactivity: Lansoprazole sodium(AG-1749) is a proton pump inhibitor which Bioactivity: Laquinimod is a potent immunomodulator which prevents prevents the stomach from producing acid. neurodegeneration and inflammation in the central nervous system.

Purity: >98% Purity: 99.84% Clinical Data: Launched Clinical Data: Phase 3 Size: 1 g, 5 g Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg, 500 mg

www.MedChemExpress.com 67

Larazotide acetate Cat. No.: HY-106268A (MK-0524) Cat. No.: HY-50175

Bioactivity: Larazotide acetate is a synthetic peptide that functions as a Bioactivity: Laropiprant is a potent, selective DP receptor antagonist tight junction regulator and reverses leaky junctions to their with Ki values of 0.57 nM and 2.95 nM for DP receptor and TP normally closed state. Receptor, respectively.

Purity: 99.53% Purity: 99.21% Clinical Data: Phase 2 Clinical Data: Phase 4 Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg 5 mg, 10 mg, 50 mg, 100 mg

LAS101057 Laurolitsine hydrochloride Cat. No.: HY-14390 ((+)-Norboldine hydrochloride) Cat. No.: HY-N2352A

Bioactivity: LAS101057 is a potent, selective, and orally efficacious A2B Bioactivity: Laurolitsine hydrochloride is an alkaloid isolated from Phoebe receptor antagonist. formosana, and shows weak anti-inflammatory activity.

Purity: >98% Purity: 99.81% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg

Lck Inhibitor Lck inhibitor 2 Cat. No.: HY-12072 Cat. No.: HY-10644

Bioactivity: Lck Inhibitor is a new class of compounds that are potent Bioactivity: Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of inhibitors of Lck with an IC50 value of 7 nM. IC50 Value: 7 nM tyrosine kinases including LCK, BTK, LYN, SYK, and TXK. The [1] Target: Lck in vitro: Lck Inhibitor (compound 25) IC50 values are 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk, exhibited good potency in the T-cell receptor-induced IL-2 Lyn, Btk and Txk respectively secretion assay (IL- 2) and also inhibited subsequent T-cell… Purity: 98.85% Purity: 99.73% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

LCMV gp33-41 LDC1267 Cat. No.: HY-P1569 Cat. No.: HY-12494

Bioactivity: LCMV gp33-41 is the H-2Db restricted epitope derived from the Bioactivity: LDC1267 is a highly selective TAM(Tyro3, Axl and Mer) kinase lymphocytic choreomeningitis virus (LCMV) glycoprotein gp 33; inhibitor with IC50 of <5 nM/8 nM/29 nM for Tyro3,Axl and residues 33 to 41. Mer respectively.

Purity: >98% Purity: 99.84% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

Leniolisib Leonurine (CDZ173) Cat. No.: HY-17635 (SCM-198) Cat. No.: HY-N0741

Bioactivity: Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor Bioactivity: Leonurine, a natural alkaloid extracted from Herba leonuri, has currently in phase II/III clinical trials for the treatment of been proved to have anti-inflammatory effect. immunodeficiency disorders.

Purity: 99.62% Purity: 99.45% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

68 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Letrazuril Leukadherin-1 Cat. No.: HY-106859 Cat. No.: HY-15701

Bioactivity: Letrazuril is a p-fluor analogue of diclazuril which can be Bioactivity: Leukadherin-1 is a specific agonist of CR3 and the leukocyte used in the prevention and treatment of coccidia infections in surface integrin CD11b/CD18. domestic fowl.

Purity: 98.27% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg, 200 mg

Leupeptin hemisulfate Cat. No.: HY-18234A ((S)-(-)-Dropropizine) Cat. No.: HY-B1895

Bioactivity: hemisulfate is a reversible, competitive Bioactivity: Levodropropizine is a histamine receptor inhibitor, serine/cysteine protease inhibitor. Levodropropizine is an effective and very well tolerated peripheral antitussive drug.

Purity: 98.0% Purity: 99.92% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 50 mg, 100 mg

Lexacalcitol Licogliflozin (KH 106; KH 1060) Cat. No.: HY-32340 (LIK066) Cat. No.: HY-109092

Bioactivity: Lexacalcitol (KH1060) is over 100 times more active than Bioactivity: Licogliflozin is a sodium glucose cotransporter ( SGLT1 and 1alpha,25-dihydroxyvitamin D3 [1alpha,25-(OH)2D3], as judged SGLT2) inhibitor. by in vitro antiproliferative and cell differentiating assays.

Purity: >98% Purity: 98.53% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 25 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Lidocaine hydrochloride (Lignocaine hydrochloride) Cat. No.: HY-B0185A (SAR 1118) Cat. No.: HY-19344

Bioactivity: Hcl salt, an amide , has Bioactivity: Lifitegrast is an integrin lymphocyte function-associated anti-inflammatory properties in vitro and in vivo, possibly antigen-1 ( LFA-1) antagonist; inhibits Jurkat T cell

due to an attenuation of pro-inflammatory cytokines, attachment to ICAM-1 with an IC50 of 2.98 nM. intracellular adhesion molecule-1 (ICAM-1), and reduction of neutrophils influx. Purity: 99.95% Purity: 99.12% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 5 g, 10 g 5 mg, 10 mg, 50 mg, 100 mg, 200 mg

Limaprost (17α,20-dimethyl-δ2-PGE1; ONO1206; OP1206) Cat. No.: HY-B0683 ((R)-(+)-α-Lipoic acid; R-(+)-Thioctic acid) Cat. No.: HY-18733

Bioactivity: Limaprost(OP1206) is a PGE1 analog and potent platelet Bioactivity: Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which adhesion inhibitor. is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

Purity: 99.76% Purity: 99.59% Clinical Data: Launched Clinical Data: Phase 4 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 50 mg 500 mg

www.MedChemExpress.com 69

Liquiritigenin Lodoxamide (4',7-Dihydroxyflavanone) Cat. No.: HY-N0377 Cat. No.: HY-14270

Bioactivity: Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, Bioactivity: Lodoxamide is an antiallergic compound acting as a mast-cell is a highly selective estrogen receptor β ( ERβ) agonist with stabilizer for the treatment of asthma and allergic

an EC50 of 36.5 nM for activation of the ERE tk-Luc. conjunctivitis.

Purity: 99.49% Purity: 98.00% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg, 200 mg

Lodoxamide tromethamine Lopinavir Cat. No.: HY-16289 (ABT-378) Cat. No.: HY-14588

Bioactivity: Lodoxamide tromethamine is a medication for the treatment of Bioactivity: Lopinavir is a potent HIV protease inhibitor with Ki of 1.3 prophylaxis of mast cell-mediated allergic disease. pM.

Purity: 98.0% Purity: 99.58% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 50 mg, 100 mg, 250 mg

Loratadine (SCH 29851; Loratidine) Cat. No.: HY-17043 (Chlortenoxicam; Ro 13-9297; TS110) Cat. No.: HY-B0367

Bioactivity: (SCH-29851) is a selective inverse peripheral Bioactivity: Lornoxicam, a COX-1 and COX-2 inhibitor, is a new nonsteroidal histamine H1-receptor agonist with an IC50 of >32 μM. anti-inflammatory drug (NSAID).

Purity: 99.95% Purity: 98.31% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 100 mg, 200 mg, 500 mg

Losmapimod Losmiprofen (GSK-AHAB; GW856553X; SB856553) Cat. No.: HY-10402 Cat. No.: HY-101642

Bioactivity: Losmapimod is a selective, potent, and orally active p38 Bioactivity: Losmiprofen is a nonsteroidal antiinflammatory agent.

MAPK inhibitor with pKis of 8.1 and 7.6 for p38α and p38β, respectively.

Purity: 97.08% Purity: >98% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 10 mg, 50 mg

Loteprednol Etabonate LOXL2-IN-1 hydrochloride Cat. No.: HY-17358 Cat. No.: HY-101771A

Bioactivity: Etabonate is an anti-inflammatory corticosteroid Bioactivity: LOXL2-IN-1 hydrochloride is a selective LOXL2 inhibitor with

used in optometry and ophthalmology. an IC50 of 126 nM.

Purity: 98.0% Purity: 98.76% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 100 mg

70 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Loxoprofen LP117 Cat. No.: HY-B0578 Cat. No.: HY-U00438

Bioactivity: is a non-steroidal anti-inflammatory drug. Bioactivity: LP117 is a novel and potent inhibitor of 5-Lipoxygenase (

5-LO) product synthesis with an IC50 of 1.1 μM.

Purity: 98.82% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 25 mg 10 mg, 50 mg, 100 mg, 200 mg

LPA1 antagonist 1 LTD4 antagonist 1 Cat. No.: HY-18076 Cat. No.: HY-U00359

Bioactivity: LPA1 antagonist 1 is a highly selective Bioactivity: LTD 4 antagonist 1 is a potent, orally active antagonist of receptor-1 (LPA1) antagonist with an IC of 25 nM. 50 leukotriene D4 ( LTD4) with a Ki of 0.57 nM.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

LTX-401 Lusutrombopag Cat. No.: HY-101949 (S-888711) Cat. No.: HY-19883

Bioactivity: LTX-401, an oncolytic amino acid derivative, targets the Golgi Bioactivity: Lusutrombopag is an orally bioavailable thrombopoietin apparatus. (TPO) receptor agonist, used for treatment of chronic liver disease.

Purity: >98% Purity: 98.81% Clinical Data: No Development Reported Clinical Data: Launched Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Luteolin-7-rutinoside LY 178002 Cat. No.: HY-N6647 Cat. No.: HY-101579

Bioactivity: -7-rutinoside has both anti-arthritic and antifungal Bioactivity: LY 178002 is a potent inhibitor of cyclooxygenase, activities, can result in a combination therapy for the 5-1ipoxygenase, phospholipase A2 and cellular production of treatment of fungal arthritis due to C. albicans infection. LTB4 by human polymorphonuclear leukocytes, with IC50 of 0.6 μM for 5-1ipoxygenase.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

LY 3000328 LY210073 Cat. No.: HY-15533 Cat. No.: HY-U00263

Bioactivity: LY 3000328 is a potent and selective Cathepsin S (Cat S) Bioactivity: LY210073 is a Leukotriene B4 ( LTB4) receptor antagonist inhibitor with IC50s of 7.7 and 1.67 nM for hCat S and mCat S, with an IC50 of 6.2 nM. respectively.

Purity: 98.62% Purity: >98% Clinical Data: Phase 1 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 5 mg, 10 mg, 50 mg

www.MedChemExpress.com 71

LY223982 M3 receptor antagonist 1 (CGS23131; SKF107324) Cat. No.: HY-112737 Cat. No.: HY-U00302

Bioactivity: LY223982 is a potent and specific inhibitor of leukotriene B4 Bioactivity: M3 receptor antagonist 1 is a muscarinic M3-receptor 3 antagonist extracted from patent WO 2008012290 A2, formula Ic. receptor, with an IC50 of 13.2 nM against [ H]LTB4 binding to LTB4 receptor.

Purity: 100.00% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

Magnolin Cat. No.: HY-N1374 Cat. No.: HY-N0163

Bioactivity: Magnolin, a major component of Magnolia flos (Shin-Yi), Bioactivity: Magnolol, a natural isolated from the stem bark of inhibits the Ras/ERKs/RSK2 signaling axis by targeting the Magnolia officinalis, is a dual agonist of both RXRα and

active pocket of ERK1 and ERK2 with IC50s of 87 nM and 16.5 PPARγ, with EC50 values of 10.4 µM and 17.7 µM, nM, respectively. respectively.

Purity: 99.98% Purity: 99.72% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg 10 mg, 50 mg, 100 mg

Manitimus Maraviroc (FK778) Cat. No.: HY-101603 (UK-427857; Selzentry; Celsentri) Cat. No.: HY-13004

Bioactivity: Manitimus is an inhibitor of dehydroorotate dehydrogenase, and Bioactivity: Maraviroc is a selective CCR5 antagonist with activity a potent immunosuppressive drug. against human HIV.

Purity: >98% Purity: 99.71% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

MART-1 (26-35) human Cat. No.: HY-P0138 (Crategolic acid; 2α-Hydroxyoleanolic acid) Cat. No.: HY-N0629

Bioactivity: MART-1 (26-35) is amino acid residue 26 to 35 of MART-1 Bioactivity: Maslinic acid can inhibit the DNA-binding activity of NF-κB protein. Sequence: Glu-Ala-Ala-Gly-Ile-Gly-Ile-Leu-Thr-Val. p65 and abolish the phosphorylation of IκB-α, which is required for p65 activation

Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg

MCC950 MCC950 sodium (CP-456773) Cat. No.: HY-12815 (CP-456773 sodium; CRID3 sodium salt) Cat. No.: HY-12815A

Bioactivity: MCC950 is a potent and selective NLRP3 inhibitor with IC50s Bioactivity: MCC950 sodium is a potent, selective NLRP3 inhibitor with IC s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively. of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively. 50

Purity: 98.0% Purity: 98.82% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg, 200 mg

72 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

MD2-IN-1 MDL 19301 Cat. No.: HY-103483 Cat. No.: HY-100286

Bioactivity: MD2-IN-1 is an inhibitor of Myeloid differentiation protein Bioactivity: MDL 19301 is a nonsteroidal, anti-inflammatory agent. 2 ( MD2) with a KD of 189 μM for the recombinant human MD2 ( rhMD2).

Purity: 99.85% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

Mebhydrolin napadisylate Cat. No.: HY-B1303A (Mebhydroline 1,5-naphthalenedisulfonate salt) Cat. No.: HY-B1303

Bioactivity: Mebhydrolin is a specific histamine H1 receptor Bioactivity: Mebhydrolin napadisylate is a specific histamine H1 antagonist. receptor antagonist.

Purity: 99.46% Purity: 99.53% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 100 mg

Medrysone (HMS; 6α-Methyl-11β-hydroxyprogesterone) Cat. No.: HY-B1076 Cat. No.: HY-B0574

Bioactivity: is a corticosteroid, in ophthalmology for the Bioactivity: Mefenamic acid is a non-steroidal anti-inflammatory agent, treatment of eye inflammations. acting as a competitive inhibitor of hCOX-1 and hCOX-2, with

IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.

Purity: 99.55% Purity: 99.99% Clinical Data: Phase 3 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 5 g, 10 g

Melittin Cat. No.: HY-P0233 Cat. No.: HY-B0261

Bioactivity: Melittin is a PLA2 activator, stimulates the activity of the Bioactivity: Meloxicam is a non-steroidal antiinflammatory agent, inhibits COX activity, with IC s of 0.49 µM and 36.6 µM for COX-2 and low molecular weight PLA 2, while it does not the increase 50 COX-1, respectively. activity of the high molecular weight PLA 2. Sequence: Gly-Il e-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-I… Purity: 96.73% Purity: 98.07% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 100 mg, 500 mg

Menbutone (Genabilic acid) Cat. No.: HY-B1136 Cat. No.: HY-B2168

Bioactivity: Menbutone is an oxobutyric acid derivative, and is a Bioactivity: Mequitazine is a potent, nonsedative and long-acting histamine

choleretic.Menbutone has a rapid onset of action, reaching its H1 antagonist. maximum plasma level within 1 hour and lasting for roughly 10 hours.

Purity: 98.51% Purity: 99.47% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

www.MedChemExpress.com 73

Metamizole sodium hydrate Methoxatin disodium salt Cat. No.: HY-B1279 (Pyrroloquinolinequinone disodium salt) Cat. No.: HY-100196A

Bioactivity: (Dipyrone) sodium hydrate is a potent analgesic Bioactivity: Methoxatin (disodium salt) as the cofactor in bovine plasma drug that has been demonstrated to inhibit cyclooxygenase amine oxidase from resonance Raman spectroscopy. (COX).

Purity: >98% Purity: 99.37% Clinical Data: Launched Clinical Data: No Development Reported Size: 500 mg Size: 10mM x 1mL in Water, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Methoxsalen Methscopolamine bromide (8-Methoxypsoralen; Xanthotoxin; 8-MOP) Cat. No.: HY-30151 ((-)- methyl bromide; Hyoscine methyl bromide) Cat. No.: HY-B0344

Bioactivity: (8-Methoxypsoralen) is a potent Bioactivity: Methscopolamine (Pamine) is a muscarinic acetylcholine furocoumarin suicide inhibitor of CYP (cytochrome P-450), is receptor blocker. Target: mAChR Methylscopolamine is an oral an agent used to treat psoriasis, eczema, vitiligo and some medication used along with other medications to treat peptic cutaneous Lymphomas in conjunction with exposing the skin to ulcers by reducing stomach acid secretion. With the advent of sunlight. proton pump inhibitors and antihistamine medications it is… Purity: 99.98% Purity: 99.44% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g 100 mg, 500 mg

Methylbenactyzium Bromide Methylprednisolone Cat. No.: HY-B2070 (U 7532) Cat. No.: HY-B0260

Bioactivity: Methylbenactyzium Bromide is a muscarinic acetylcholine Bioactivity: Methylprednisolone is a synthetic corticosteroid with receptor ( mAChR) inhibitor. anti-inflammatory and immunomodulating properties. Target: Glucocorticoid Receptor Methylprednisolone is typically used for its anti-inflammatory effects. Common uses include arthritis therapy and short-term treatment of bronchial… Purity: 98.0% Purity: 99.67% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg, 200 mg 100 mg, 500 mg

Methylprednisolone succinate Methylthiouracil (Methylprednisolone hydrogen succinate) Cat. No.: HY-B1900 (MTU) Cat. No.: HY-B0513

Bioactivity: Methylprednisolone succinate is a synthetic glucocorticoid and Bioactivity: Methylthiouracil is an antithyroid agent. Methylthiouracil widely used as an anti-inflammatory agent. suppresses the production TNF-α and IL-6, and the activation of NF-κB and ERK1/2.

Purity: 99.14% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg, 200 mg 50 mg, 100 mg

MF63 Mito-TEMPO Cat. No.: HY-13283 Cat. No.: HY-112879

Bioactivity: MF63 is a selective mPGES-1 inhibitor with an IC50 of 0.9 nM Bioactivity: Mito-TEMPO is a mitochondria-targeted and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, mimetic with superoxide and alkyl radical scavenging respectively. properties.

Purity: 98.94% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg 5 mg, 10 mg, 50 mg, 100 mg

74 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Mizolastine dihydrochloride Cat. No.: HY-B0164 Cat. No.: HY-B0164A

Bioactivity: Mizolastine is a histamine H1-receptor antagonist with IC50 of Bioactivity: Mizolastine dihydrochloride is a histamine H1-receptor 47 nM used in the treatment of hay fever (seasonal allergic antagonist with IC50 of 47 nM used in the treatment of hay rhinitis), hives and other allergic reactions. fever (seasonal allergic rhinitis), hives and other allergic reactions.

Purity: 99.33% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 100 mg, 200 mg, 500 mg Size: 100 mg, 200 mg, 500 mg

Mizoribine MK-0429 (NSC 289637; HE 69) Cat. No.: HY-17470 (L-000845704) Cat. No.: HY-15102

Bioactivity: Mizoribine(NSC 289637; HE 69; β-Bredinin) is an Bioactivity: MK-0429 is a potent integrin antagonist with IC50s of 12.2 immunosuppressive agents (IC50=100 uM) that inhibit the nM (α5β1 integrin) and 2.8 nM (αvβ3 integrin), respectively. proliferation of lymphocytes selectively, via inhibition of IMPDH.

Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 10 mg, 50 mg, 100 mg

MK-0812 MK-0812 Succinate Cat. No.: HY-50669 Cat. No.: HY-50669A

Bioactivity: MK-0812 is a potent and selective CCR2 antagonist with low nM Bioactivity: MK-0812 Succinate is a potent and selective CCR2 antagonist affinity for CCR2 on human monocytes. with high affinity at CCR2 on human monocytes.

Purity: 99.75% Purity: 99.57% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

MK-2894 MK-2894 sodium salt Cat. No.: HY-10413 Cat. No.: HY-10414

Bioactivity: MK-2894 is a highly potent and selective second generation EP4 Bioactivity: MK-2894 sodium salt is a highly potent and selective second antagonist. generation EP4 antagonist.

Purity: 98.10% Purity: 98.09% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg

MK-447 MK-571 sodium salt Cat. No.: HY-100297 (L-660711 sodium salt) Cat. No.: HY-19989A

Bioactivity: MK-447 is a free radical scavenger, also a nonsteroidal Bioactivity: MK-571 sodium salt is a potent, selective, orally active antiinflammatory agent, and enhances the formation of the 3 leukotriene receptor antagonist, which inhibits [ H] LTD4 endoperoxide, PGH 2, and other . binding in guinea pig lung with a Ki of 0.22±0.15 nM and [ 3 H] LTD4 binding in human lung with a Ki of 2.1±1.8 nM. Purity: >98% Purity: 99.24% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg

www.MedChemExpress.com 75

MK-7246 MK-7246 S enantiomer Cat. No.: HY-15853 Cat. No.: HY-15853A

Bioactivity: MK-7246 is a potent and selective CRTH2 antagonist with a Ki Bioactivity: MK-7246 S enantiomer is the less active enantiomer of MK-7246. of 2.5±0.5 nM. MK-7246 is a potent and selective CRTH2 antagonist.

Purity: 98.16% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg 5 mg, 10 mg, 25 mg

MK-8617 MK2-IN-1 hydrochloride Cat. No.: HY-101023 (MK2 Inhibitor) Cat. No.: HY-12834A

Bioactivity: MK-8617 is an orally active pan-inhibitor of hypoxia-inducible Bioactivity: MK2-IN-1 hydrochloride is a potent and selecitve MAPKAPK2(MK2)

factor prolyl hydroxylase 1-3 ( HIF PHD1-3) with an IC50 of 1 inhibitor(IC50=0.11 uM) with a non-ATP competitive binding nM for PHD2. mode.

Purity: 98.0% Purity: 97.32% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg 5 mg, 10 mg, 50 mg

MK591 MK591 free acid (Quiflapon sodium) Cat. No.: HY-50714 (Quiflapon) Cat. No.: HY-10037

Bioactivity: MK591 is a selective and specific 5-Lipoxygenase-activating Bioactivity: MK591 (free acid) is a selective and specific protein ( FLAP) inhibitor. 5-Lipoxygenase-activating protein (FLAP) inhibitor with an IC

50 value of 1.6 nM in a FLAP binding assay.

Purity: 99.25% Purity: 95.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

ML RR-S2 CDA ML RR-S2 CDA ammonium salt (STING-Inducer-1) Cat. No.: HY-12885 (STING-Inducer-1 ammonium salt) Cat. No.: HY-12885B

Bioactivity: ML RR-S2 CDA (STING-Inducer-1) is a highly active Bioactivity: ML RR-S2 CDA ammonium salt is an activator of stimulator of cyclic-di-nucleotide immune stimulators that activate DCs via interferon genes ( STING). the cytoplamtic receptor STING (Stimulator of Interferon Genes).

Purity: 99.23% Purity: 99.23% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg 1 mg, 5 mg, 10 mg, 25 mg, 50 mg

ML-030 ML355 Cat. No.: HY-103050 Cat. No.: HY-12341

Bioactivity: ML-030 is a potent PDE4 inhibitor, with IC50 of 6.7 nM, 12.9 Bioactivity: ML355 is a potent and selective inhibitors of nM, 48.2 nM, 37.2 nM, 452 nM and 49.2 nM for PDE4A, PDE4A1, 12-Lipoxygenase(12-LOX) with IC50 of 0.34 μM, excellent PDE4B1, PDE4B2, PDE4C1,and PDE4D2, respectively. selectivity over related lipoxygenases and , and possess favorable ADME properties. IC50 value: 0.34 μM [1] Target: 12-LOX ML355 inhibits PAR-4 induced aggregation and… Purity: 99.32% Purity: 98.28% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

76 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Mometasone furoate Monoammonium glycyrrhizinate hydrate (Sch32088) Cat. No.: HY-13693 Cat. No.: HY-76225

Bioactivity: furoate, prodrug of the free form mometasone, is a Bioactivity: Monoammonium glycyrrhizinate hydrate has various agent with high affinity for the glucocorticoid receptor. pharmacological actions such as anti-inflammatory, antiallergic, antigastriculcer, and antihepatitis activities. In Vivo: The increase of the lung W/D weight ratios is significantly reduced by high and medium dose of MAG (10 and… Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg, 200 mg, 500 mg 1 g

Montelukast sodium Morusin Cat. No.: HY-13315 (Mulberrochromene) Cat. No.: HY-N0622

Bioactivity: sodium is a potent, selective CysLT1 receptor Bioactivity: Morusin is a prenylated flavonoid isolated from M. australis antagonist. with various biological activities, such as antitumor, antioxidant, and anti-bacteria property. Morusin could inhibit NF-κB and STAT3 activity.

Purity: 99.82% Purity: 99.08% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg, 500 mg 2 mg, 5 mg, 10 mg, 25 mg

MRT67307 MS417 Cat. No.: HY-13018 (GTPL7512) Cat. No.: HY-111139

Bioactivity: MRT67307 is a dual inhibitor of the IKKε and TBK-1, which Bioactivity: MS417 is a BET-specific BRD4 inhibitor, binds to BRD4-BD1 and

mediates the phosphorylation of interferon regulatory factor 3 BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, (IRF3), with IC50 values of 160 and 19 nM when assayed at 0.1 respectively, with weak selectivity at CBP BRD ( IC50, 32.7 mM ATP in vitro, and also targets ULK1 and ULK2 with h… μM). Purity: 99.00% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

MSX-122 MTPPA Cat. No.: HY-13696 (M 5011) Cat. No.: HY-101670

Bioactivity: MSX-122 is a partial antagonist of CXCR4, inhibiting Bioactivity: MTPPA is a drug for treating symptoms of inflammation and pain. CXCR4/CXCL12 actions, with an IC50 of 10 nM; MSX-122 has anti-inflammatory and anti-metastatic activity.

Purity: 99.74% Purity: >98% Clinical Data: Phase 1 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 50 mg, 100 mg

MUC5AC motif peptide Cat. No.: HY-P0280 (Mycophenolate) Cat. No.: HY-B0421

Bioactivity: MUC5AC motif peptide is a 16-amino acid fragment of mucin 5. Bioactivity: Mycophenolic acid is an an immunosuppresant drug and has Sequence: Gly-Thr-Thr-Pro-Ser-Pro-Val-Pro-Thr-Thr-Ser-Thr-Thr- potent anti-proliferative activity. Ser-Ala-Pro.

Purity: >98% Purity: 99.24% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 100 mg, 500 mg, 1 g

www.MedChemExpress.com 77

Myelin Basic Protein (MBP) (68-82), guinea pig N-Acetyl-Ser-Asp-Lys-Pro Cat. No.: HY-P1048 Cat. No.: HY-P0266

Bioactivity: Myelin Basic Protein (MBP) (68-82), guinea pig is a fragment Bioactivity: N-Acetyl-Ser-Asp-Lys-Pro is a natural and specific substrate of myelin basic protein (MBP). for the N-terminal site of ACE. Sequence: Ac-Ser-Asp-Lys-Pro.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 25 mg 1 mg, 5 mg, 10 mg

N-Acetylcysteine amide N-Acetylhistamine Cat. No.: HY-110256 (N-Omega-acetylhistamine) Cat. No.: HY-112175

Bioactivity: N-Acetylcysteine amide is a cell membranes and blood brain Bioactivity: N-acetylhistamine is a histamine metabolite. N-acetylhistamine barrier permeant thiol antioxidant and neuroprotective agent. can be used as a potential biomarker of histidine metabolism for anaphylactoid reactions.

Purity: 99.0% Purity: 98.99% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg 50 mg

N-Formyl-Met-Leu-Phe N6-(2-Phenylethyl)adenosine (fMLP; N-Formyl-MLF) Cat. No.: HY-P0224 (N6-Phenethyladenosine; N6-Phenylethyladenosine) Cat. No.: HY-101854

Bioactivity: N-Formyl-Met-Leu-Phe (fMLP; N-Formyl-MLF) is a chemotactic Bioactivity: N6-(2-Phenylethyl)adenosine is a selective A1 adenosine peptide and a specific ligand of N- receptor agonist. (FPR). N-Formyl-Met-Leu-Ph is reported to inhibit TNF-alpha secretion.

Purity: 99.46% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg, 200 mg

N6022 Cat. No.: HY-14984 (BRL14777) Cat. No.: HY-B0559

Bioactivity: N6022 is a potent, selective, reversible, and efficacious Bioactivity: Nabumetone is an orally active non-acidic anti-inflammatory

S-Nitrosoglutathione reductase(GSNOR) inhibitor with IC50 of 8 agent, acts as a potent and selective COX-2 inhibitor, and is nM. the prodrug of the active metabolite 6MNA.

Purity: 98.62% Purity: 99.86% Clinical Data: Phase 1 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 1 g, 5 g

Nadifloxacin Nafocare B1 (OPC7251) Cat. No.: HY-B0506 (Methylfurylbutyrolactone) Cat. No.: HY-100241

Bioactivity: Nadifloxacin(OPC7251) is a topical fluoroquinolone Bioactivity: Nafocare B1 is a synthetic immune biological response for the treatment of vulgaris. modifier.

Purity: 99.29% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 1 g, 5 g

78 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Naproxen Naproxen etemesil ((S)-Naproxen) Cat. No.: HY-15030 (LT-NS 001; MX 1094) Cat. No.: HY-19675

Bioactivity: Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 Bioactivity: Naproxen etemesil is a lipophilic, non-acidic, inactive and 5.15 μM, respectively in cell assay. prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2

inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. Purity: 99.66% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 g, 10 g

Naproxen sodium Naringin Cat. No.: HY-15030A (Naringoside) Cat. No.: HY-N0153

Bioactivity: Naproxen sodium is a COX-1 and COX-2 inhibitor with IC50s of Bioactivity: Naringin is a major flavanone glycoside obtained from 8.72 and 5.15 μM, respectively in cell assay. tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities.

Purity: 99.98% Purity: 99.50% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 g, 10 g 200 mg, 10 g

Navarixin NBI-74330 (SCH 527123; MK-7123) Cat. No.: HY-10198 Cat. No.: HY-15320

Bioactivity: Navarixin is a potent, allosteric antagonist of both CXCR1 Bioactivity: NBI-74330 is a potent antagonist for CXCR3, and exhibits 125 125 and CXCR2, with Kd values of 41 nM for cynomolgus CXCR1 and potent inhibition of ( I)CXCL10 and ( I)CXCL11 specific 0.20 nM, 0.20 nM, 0.08 nM for mouse, rat and cynomolgus monkey binding with Ki of 1.5 and 3.2 nM, respectively. CXCR2, respectivelly.

Purity: 99.06% Purity: 98.0% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

NCX1022 NecroX-5 Cat. No.: HY-U00187 Cat. No.: HY-104015

Bioactivity: NCX1022 is an NO-releasing derivative of Hydrocortisone, which Bioactivity: NecroX-5 is a derivative of the NecroX, reduces intracellular is the most widely used anti-inflammatory drug for the calcium concentration, and possesses anti-inflammatory and treatment of skin inflammation. anti-cancer activity.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Nedocromil sodium (FPL 59002) Cat. No.: HY-13448 (FPL 59002KP; Nedocromil disodium salt) Cat. No.: HY-16344

Bioactivity: Nedocromil suppresses the action or formation of multiple Bioactivity: Nedocromil sodium suppresses the action or formation of

mediators, including histamine, leukotriene C4 ( LTC4), multiple mediators, including histamine, leukotriene C4 (

and prostaglandin D2 ( PGD2). LTC4), and prostaglandin D2 ( PGD2).

Purity: 95.66% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 5 mg, 10 mg

www.MedChemExpress.com 79

Neflamapimod Neochlorogenic acid (VX-745) Cat. No.: HY-10328 (trans-5-O-Caffeoylquinic acid) Cat. No.: HY-N0722

Bioactivity: VX-745 is a potent and selective inhibitor of p38α, and Bioactivity: Neochlorogenic acid is a natural polyphenolic compound found possesses anti-inflammatory activity. in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and IL-1β. Neochlorogenic acid suppresses iNOS and COX-2 protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK… Purity: 98.74% Purity: 99.46% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 5 mg, 10 mg

Neohesperidin Neohesperidin dihydrochalcone (Hesperetin 7-O-neohesperidoside) Cat. No.: HY-N0101 (Neohesperidin DC; NHDC) Cat. No.: HY-N0154

Bioactivity: Neohesperidin is a flavonoid compound found in high amounts in Bioactivity: Neohesperidin dihydrochalcone is a synthetic glycoside Poncirus trifoliata with anti-oxidant and anti-inflammatory chalcone, is added to various foods and beverages as a low effects. caloric artificial sweetener.

Purity: 95.10% Purity: 98.04% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg, 100 mg, 500 mg, 1 g, 5 g 100 mg, 500 mg, 1 g, 5 g

Nepafenac Neurokinin antagonist 1 (AHR 9434; AL 6515) Cat. No.: HY-17357 Cat. No.: HY-U00320

Bioactivity: (AHR 9434; AL 6515; Nevanac) is a selective COX-2 Bioactivity: Neurokinin antagonist 1 is a Neurokinin antagonist inhibitor; is prodrug of Amfenac. extracted from patent WO1998045262A1.

Purity: 95.14% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 10 mg, 50 mg, 100 mg

NF-κB inducing kinase inhibitor NFAT Inhibitor Cat. No.: HY-112433 (VIVIT peptide; 11R-VIVIT) Cat. No.: HY-P1026

Bioactivity: NF-κB inducing kinase inhibitor is a potent, selective NF-κB Bioactivity: NFAT Inhibitor is a selective inhibitor of inducing kinase ( NIK) inhibitor, which inhibits NIK-catalyzed calcineurin-mediated dephosphorylation of nuclear factor of

hydrolysis of ATP to ADP with IC 50 of 0.23±0.17 nM. activated T cells (NFAT). Sequence: Met-Ala-Gly-Pro-His-Pro-Va l-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu.

Purity: >98% Purity: 98.41% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500 mg, 250 mg Size: 10mM x 1mL in Water, 1 mg, 5 mg, 10 mg, 25 mg

NFAT Transcription Factor Regulator NG25 Cat. No.: HY-112778 Cat. No.: HY-15434

Bioactivity: NFAT Transcription Factor Regulator is an IL-2 synthesis Bioactivity: NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with

inhibitor with an IC50 of 182 nM. IC50s of 149 nM and 21.7 nM, respectively.

Purity: >98% Purity: 99.45% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg

80 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

NI-57 NIBR189 Cat. No.: HY-19537 Cat. No.: HY-12336

Bioactivity: NI-57 is an inhibitor of bromodomain and plant homeodomain Bioactivity: NIBR189 is a small molecule antagonist of the Epstein-Barr

finger-containing ( BRPF) famlily of proteins, with IC50s of virus-induced gene 2 (EBI2; GPR183) receptor with IC50 of 16 3.1, 46 and 140 nM for BRPF1, BRPF2 (BRD1) and BRPF3, nM(Binding) and 11 nM (Functional). respectively.

Purity: 99.89% Purity: 99.24% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

Nicotinamide N-oxide Cat. No.: HY-101407 Cat. No.: HY-17475

Bioactivity: N-oxide, an in vivo nicotinamide metabolite, is a Bioactivity: Nifenazone is a pyrazole drug which can be used in the in the potent, and selective antagonist of the CXCR2 receptor. treatment of a variety of rheumatic disorders.

Purity: 99.45% Purity: 99.55% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 100 mg

Niflumic acid NIM811 Cat. No.: HY-B0493 ((Melle-4)cyclosporin; SDZ NIM811) Cat. No.: HY-P0025

Bioactivity: , a Ca2+-activated Cl- channel blocker, is an Bioactivity: NIM811 (SDZ NIM811) is a potent mitochondrial permeability analgesic and anti-inflammatory agent used in the treatment of transition inhibitor. Sequence: rheumatoid arthritis. Cyclo[{Aaa}-{Abu}-{Sar}-Ile-Val-Leu-Ala-{D-Ala}-Leu-Leu-Val].

Purity: 99.86% Purity: 99.55% Clinical Data: Launched Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 1 mg, 5 mg

Nimesulide (R805) Cat. No.: HY-B0363 Cat. No.: HY-B0310

Bioactivity: is a selective COX-2 inhibitor, with IC50s of 70 Bioactivity: Nizatidine is a histamine H2 receptor antagonist with low nM-70 μM in a time-dependent manner, but it shows no effect on toxicity that inhibits gastric acid secretion.

COX-1 (IC 50 >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties. Purity: 99.91% Purity: 99.49% Clinical Data: Phase 4 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 1 g, 5 g

NO-prednisolone NOD-IN-1 (NCX-1015) Cat. No.: HY-101757 Cat. No.: HY-100691

Bioactivity: NO-prednisolone is a nitric oxide (NO)-releasing derivative of Bioactivity: NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding Prednisolone. NO-prednisolone potently stimulates IL-10 oligomerization domain ( NOD)-like receptors, NOD1 and NOD2,

production in vivo. with IC50 of 5.74 μM and 6.45 μM, respectively.

Purity: 98.58% Purity: 98.99% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

www.MedChemExpress.com 81

Nodinitib-1 Norethindrone acetate (ML130; CID-1088438) Cat. No.: HY-18639 (19-Norethindrone acetate) Cat. No.: HY-B1710

Bioactivity: Nodinitib-1 (ML130;CID-1088438) is a NOD1 inhibitor with an Bioactivity: Norethindrone acetate is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by IC50 of 0.56 μM. abnormal hormone levels, and secondary amenorrhea.

Purity: 98.0% Purity: 99.33% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 100 mg, 500 mg

Nosantine racemate NS-398 (NPT-15392 racemate) Cat. No.: HY-101687 Cat. No.: HY-13913

Bioactivity: Nosantine racemate is the racemate of Nosantine. Nosantine is Bioactivity: NS-398 is a non-steroidal an-inflammatory agent with analgesic an inducer of IL-2 or enhancer of IL-2 induction by and antipyretic effects, and selectively inhibits phytohemagglutinin (PHA). prostaglandin G/H synthase 2/cyclooxygenase 2 ( COX-2)

activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM. Purity: >98% Purity: 99.79% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

NS6180 NSC117079 Cat. No.: HY-15707 Cat. No.: HY-19819

Bioactivity: NS6180 is a novel potent and selective KCa3.1 channel Bioactivity: NSC117079 is a novel PHLPP inhibitor. inhibitor(IC50= 9 nM) prevents T-cell activation and inflammation.

Purity: 99.99% Purity: 98.90% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

NSC297623 Nucleoprotein 396-404 (W2395; Meseclazone) Cat. No.: HY-U00157 (NP 396) Cat. No.: HY-P1571

Bioactivity: Meseclazone exhibits inhibitory potency of secondary phase ADP Bioactivity: Nucleoprotein (396-404) is the 396 to 404 fragment of aggregation. Meseclazone possesses anti-inflammatory, lymphocytic choriomeningitis virus (LCMV). Nucleoprotein analgesic and antipyretic activity. (396-404) is the H-2D(b)-restricted immunodominant epitope and can be used as a molecular model of viral antigen.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg

OC000459 Oclacitinib maleate (Timapiprant) Cat. No.: HY-15342 (PF-03394197 maleate) Cat. No.: HY-13577A

Bioactivity: OC000459 is a potent and selective D prostanoid receptor 2 Bioactivity: Oclacitinib maleate is a novel JAK inhibitor. Oclacitinib is

(DP2) antagonist with IC50 of 13 nM. IC50 Value: 13 nM( Ki for most potent at inhibiting JAK1 ( IC50=10 nM). hrCRTH2); 3 nM( Ki for Rat rCRTH2);13 nM(Ki for human native CRTH2) Target: D prostanoid receptor 2 CRTH2 (chemoattractant receptor expressed on T-helper (Th) type 2 cells) is a… Purity: 95.12% Purity: 99.53% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg

82 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Octreotide Oglemilast (SMS 201-995) Cat. No.: HY-P0036 (GRC 3886) Cat. No.: HY-15178

Bioactivity: Octreotide is a somatostatin analog that binds to the Bioactivity: Oglemilast(GRC3886) is a potent PDE4 inhibitor, under clinical , mainly subtypes 2, 3, and 5, studies in the treatment of -induced asthma. increases Gi activity, and reduces intracellular cAMP production. Sequence: Phe-Cys-Phe-Trp-Lys-Thr-Cys-Thr(Disulfide bridge: Cys2-Cys7). Purity: 99.15% Purity: 96.83% Clinical Data: Launched Clinical Data: Phase 2 Size: 1 mg, 5 mg, 10 mg, 25 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg

Oleanolic acid derivative 1 derivative 2 Cat. No.: HY-18002 Cat. No.: HY-18003

Bioactivity: Oleanolic acid derivative 1 is an oleanolic acid derivative, Bioactivity: Oleanolic acid derivative 2 is an oleanolic acid derivative, which is a novel triterpenoid-steroid hybrid molecule. which is a novel triterpenoid-steroid hybrid molecule.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg 1 mg, 5 mg

Olopatadine hydrochloride Omtriptolide (ALO4943A; KW4679) Cat. No.: HY-B0426A Cat. No.: HY-16363

Bioactivity: HCl is a histamine blocker used to treat allergic Bioactivity: Omtriptolide (PG490-88) is a water soluble derivative prodrug conjunctivitis. of triptolide purified from the Chinese herb.

Purity: 99.55% Purity: 98.29% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 1 mg, 5 mg, 10 mg, 25 mg

ONO4057 ONX-0914 (ONO-LB457) Cat. No.: HY-U00252 (PR-957) Cat. No.: HY-13207

Bioactivity: ONO4057 is a antagonist, with an IC50 Bioactivity: ONX-0914 (PR-957) is a potent and selective immunoproteasome of 0.7±0.3 μM. inhibitor with minimal cross-reactivity for the constitutive proteasome.

Purity: >98% Purity: 98.86% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

opigolix Oridonin Cat. No.: HY-U00289 (Isodonol) Cat. No.: HY-N0004

Bioactivity: Opigolix is a Gonadotropin-releasing hormone ( GnRH) receptor Bioactivity: Oridonin, a diterpenoid isolated from Rabdosia rubescens, acts

antagonist, used for the research of endometriosis and as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 rheumatoid arthritis. and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects.

Purity: >98% Purity: 99.85% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg

www.MedChemExpress.com 83

Osajin (CID 95168; NSC 21565) Cat. No.: HY-N3125 (LCI699) Cat. No.: HY-16276

Bioactivity: Osajin is the major bioactive isoflavone present in the fruit Bioactivity: Osilodrostat (LCI699) is a potent inhibitor of human

of Maclura pomifera with antitumor, antioxidant and 11β-hydroxylase and aldosterone synthase with IC50 values of anti-inflammatory activities. 2.5 and 0.7 nM, respectively.

Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Phase 3 Size: 5 mg Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

OVA Peptide 323-339 Cat. No.: HY-P0286 (Oxaprozinum; Wy21743) Cat. No.: HY-B0808

Bioactivity: OVA Peptide (323-339) represents a T and B cell epitope of Bioactivity: Oxaprozin is an inhibitor of both COX-1 and COX-2 with IC50s Ovalbumin (Ova), which is important in the generation and of 2.2 μM and 36 μM for human platelet COX-1 and development of immediate hypersensitivity responses in BALB/c IL-1-stimulated human synovial cell COX-2, respectively. mice. Sequence: Ile-Ser-Gln-Ala-Val-His-Ala-Ala-His-Ala-Glu-Il Oxaprozin also inhibits the activation of NF-κB. e-Asn-Glu-Ala-Gly-Arg. Purity: 99.85% Purity: 99.63% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg

Oxeladin citrate Cat. No.: HY-B1216 Cat. No.: HY-U00105

Bioactivity: Oxeladin citrate is a cough suppressant, is a highly potent Bioactivity: Oxitropium bromide is an mAChR antagonist used as an and effective drug used to treat all types of cough of various anticholinergic bronchodilator drug for the treatment of etiologies. asthma and chronic obstructive pulmonary disease.

Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 5 mg 100 mg

Oxolamine citrate Oxymatrine (SKF-9976 citrate; AF-438 citrate) Cat. No.: HY-B1042 Cat. No.: HY-N0158

Bioactivity: Oxolamine citrate is a cough suppressant. Bioactivity: Oxymatrine, an alkaloid from the roots of Sophora species, with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway.

Purity: 98.54% Purity: 98.0% Clinical Data: Launched Clinical Data: Phase 4 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g 100 mg, 200 mg, 500 mg, 1 g

Ozanimod p2Ca (RPC-1063) Cat. No.: HY-12288 Cat. No.: HY-P0260

Bioactivity: Ozanimod is a potent and selective S1P1 and S1P5 receptor Bioactivity: p2Ca, an 8-mer peptide, is a ligand that is naturally agonist with EC s of 410±160 pM and 11±4.3 nM in [ processed and presented to the Ld-alloreactive T cell clone, 50 2C. Sequence: Leu-Ser-Pro-Phe-Pro-Phe-Asp-Leu. 35S]-GTPγS binding, respectively.

Purity: 99.81% Purity: >98% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

84 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

PAC-14028 PAF-AN-1 (Asivatrep) Cat. No.: HY-12777 Cat. No.: HY-U00040

Bioactivity: PAC-14028 is a potent and selective transient receptor Bioactivity: PAF-AN-1 is a platelet activating factor receptor ( PAF) potential vanilloid type I ( TRPV1) antagonist. antagonist.

Purity: 95.03% Purity: >98% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

Pamidronic acid PAP-1 Cat. No.: HY-B0012 (5-(4-Phenoxybutoxy)) Cat. No.: HY-10015

Bioactivity: Pamidronic acid is a drug used to treat a broad spectrum of Bioactivity: PAP-1 is a selective inhibitor of Kv1.3, voltage-gated K+ bone absorption diseases. channel. PAP-1 (EC50=2 nM) potently inhibits human T effector memory cell proliferation and delayed hypersensitivity. IC50 value: 2 nM (EC50) [1] in vitro: blocks Kv1.3 in a use-dependent manner, with a Hill coefficient of 2 and an EC50… Purity: 98.0% Purity: 99.69% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 50 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Papain Paquinimod Cat. No.: HY-P1645 (ABR 25757) Cat. No.: HY-100442

Bioactivity: Papain is a cysteine protease of the peptidase C1 family, Bioactivity: Paquinimod is a S100A9 inhibitor, which prevents S100A9 which is used in food, pharmaceutical, textile, and cosmetic binding to TLR-4. industries.

Purity: >98% Purity: 98.38% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

PAR-4 Agonist Peptide, amide Parcetasal (PAR-4-AP; AY-NH2) Cat. No.: HY-P1309 (MR-897) Cat. No.: HY-U00100

Bioactivity: PAR-4 Agonist Peptide, amide is a proteinase-activated Bioactivity: Paclitaxal is a non-steroidal anti-inflammatory analgesic. receptor-4 ( PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

Parecoxib Sodium (SC 69124) Cat. No.: HY-17474 (SC 69124A) Cat. No.: HY-17474A

Bioactivity: Parecoxib is a potent and selective COX-2 inhibitor. Bioactivity: Parecoxib is a potent and selective COX-2 inhibitor.

Purity: 99.32% Purity: 99.85% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 25 mg, 50 mg, 100 mg 25 mg, 50 mg, 100 mg

www.MedChemExpress.com 85

Parimifasor Paritaprevir (LYC30937) Cat. No.: HY-109098 (ABT-450; Veruprevir) Cat. No.: HY-12594

Bioactivity: Parimifasor is an immunomodulator, with anti-inflammatory Bioactivity: Paritaprevir (ABT-450) is a potent non-structural protein 3/4A

activity. ( NS3/4A) protease inhibitor with EC50s of 1 and 0.21 nM against HCV 1a and 1b, respectively.

Purity: 97.00% Purity: 98.87% Clinical Data: No Development Reported Clinical Data: Phase 4 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

Pasiniazid (Paraniazide; Pasiniazide; Isonicotinic acid PAT-1251 Hydrochloride hydrazide p-aminosalicylate) Cat. No.: HY-B1048 Cat. No.: HY-107422A

Bioactivity: Pasiniazid is an anti-TB and anti-leprosy drug, used to treat Bioactivity: PAT-1251 Hydrochloride is a potent, selective and oral lysyl

various types of TB and leprosy. oxidase-like 2 ( LOXL2) inhibitor, with IC50s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently

inhibits mouse, rat, and dog LOXL2 ( IC50s, 0.10, 0.12, … Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 1 g

PAT-505 PBI-4050 sodium salt Cat. No.: HY-107781 (Setogepram (sodium salt)) Cat. No.: HY-100775

Bioactivity: PAT-505 is a potent, selective, noncompetitive and orally Bioactivity: PBI-4050 acts as an agonist for GPR40 and as an antagonist or

available autotaxin inhibitor, with an IC50 of 2 nM in Hep3B inverse agonist for GPR84. cells, 9.7 nM in human blood and 62 nM in mouse plasma.

Purity: >98% Purity: 99.39% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

PCI 29732 PD-1-IN-1 Cat. No.: HY-18010 Cat. No.: HY-101093

Bioactivity: PCI 29732 is a selective and irreversible Btk inhibitor with Bioactivity: PD-1-IN-1 is an inhibitor of programmed cell dealth-1 ( PD-1) IC50 of 8.2 nM in a FRET based biochemical enzymology assay. extracted from patent WO 2015033299 A1, compound example 4.

Purity: >98% Purity: 98.48% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

PD1-IN-2 PDE IV-IN-1 Cat. No.: HY-101098 Cat. No.: HY-U00352

Bioactivity: PD1-IN-2 is a PD1 signaling pathway inhibitor, which acts as Bioactivity: PDE IV-IN-1 is an inhibitor of phosphodiesterase IV, used for an immunomodulator. the research of asthma, COPD or other inflammatory diseases.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

86 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

PDM2 Peficitinib Cat. No.: HY-112629 (ASP015K; JNJ-54781532) Cat. No.: HY-19568

Bioactivity: PDM2 is a selective, high-affinity aryl hydrocarbon receptor ( Bioactivity: Peficitinib is an oral JAK inhibitor, with IC50s of 3.9, 5.0, AhR) antagonist with an K of 1.2±0.4 nM. i 0.7 and 4.8 nM for JAK1, JAK2, JAK3 and Tyk2, respectively.

Purity: 98.88% Purity: 99.43% Clinical Data: No Development Reported Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Peimine Peiminine (Verticine; Dihydroisoimperialine) Cat. No.: HY-N0212 (Verticinone; Raddeanine) Cat. No.: HY-N0213

Bioactivity: Peimine(Dihydroisoimperialine; Verticine) is a natural Bioactivity: Peiminine(Verticinone; Raddeanine) is a natural compound with compound with good anti-inflammatory effects in vivo. anti-inflammatory activity. IC50 value: Target: Peiminine and DXS significantly reduced alveolar inflammation and pulmonary interstitial inflammation in rats with -induced lung injury. peiminine inhibits lung inflammation and pulmonary… Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 5 mg, 10 mg

Pemafibrate Pemirolast potassium ((R)-K-13675) Cat. No.: HY-17618 (TWT-8152; BMY 26517) Cat. No.: HY-B0538A

Bioactivity: Pemafibrate is a potent PPARα agonist, with EC50s of 1 nM, Bioactivity: Pemirolast Potassium (BMY 26517) is a histamine H1 antagonist 1.10 μM and 1.58 μM for h-PPARα, h-PPARγ and h-PPARδ, and mast cell stabilizer that acts as an antiallergic agent. respectively, and possesses lipid-lowering effect. Target: Histamine H1 Receptor Pemirolast potassium (BMY 26517) is a new oral, nonbronchodilator antiallergy medication that is being evaluated for the therapy of asthma [1]. Pemirolast… Purity: 99.78% Purity: 99.96% Clinical Data: Phase 3 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 10 mg, 50 mg, 100 mg

Penicillamine Pentanoic acid (D-(-)-Penicillamine) Cat. No.: HY-B0300 Cat. No.: HY-N6056

Bioactivity: Penicillamine is the most characteristic degradation product Bioactivity: Pentanoic acid, a short-chain fatty acid, is a product of of the penicillin . It is used as an antirheumatic bacterial metabolism and are associated with allergic skin and as a chelating agent in Wilson's disease. Target: Others disorders. Pentanoic acid activates ROCK signaling pathway. Penicillamine(Cuprimine, Depen) is used as an antirheumatic and as a chelating agent in Wilson's disease and is a… Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: Size: 10mM x 1mL in Water, Size: 10 mg 1 g, 5 g

Pentosan Polysulfate Peptide 401 Cat. No.: HY-A0203 Cat. No.: HY-12537

Bioactivity: Pentosan Polysulfate is a semi-synthetic drug used to treat Bioactivity: Peptide 401, a potent mast cell degranulating factor from bee various medical conditions including thrombi and interstitial venom, suppresses the increased vascular permeability due to cystitis. intradermal injection of various spasmogens ( histamine, and 5-HT).

Purity: 98.0% Purity: 98.29% Clinical Data: Launched Clinical Data: No Development Reported Size: 100 mg Size: 500u g, 1 mg, 5 mg

www.MedChemExpress.com 87

PF-06260933 PF-06651600 Cat. No.: HY-19562 Cat. No.: HY-100754

Bioactivity: PF-06260933 is a highly selective small-molecule inhibitor of Bioactivity: PF-06651600 is a potent JAK3-selective inhibitor with an IC50 MAP4K4 with IC s of 3.7 and 160 nM for kinase and cell, 50 of 33.1 nM. respectively.

Purity: 99.69% Purity: 99.98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg

PF-3845 PF-3893787 hydrochloride Cat. No.: HY-14380 Cat. No.: HY-19705B

Bioactivity: PF-3845 is a selective fatty acid amide hydrolase (FAAH) Bioactivity: PF-3893787 hydrochloride is a novel inhibitor (Ki = 0.23 μM); showing negligible activity against antagonist binding affinity ( Ki=2.4 nM) and is also a FAAH2. functional ( Ki=1.56 nM) antagonist.

Purity: 98.94% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

PF-4136309 PF-4840154 (INCB8761) Cat. No.: HY-13245 Cat. No.: HY-18779

Bioactivity: PF-4136309 is a potent, selective, and orally bioavailable Bioactivity: PF-4840154 is a potent, selective agonist of the rat and human

CCR2 antagonist, with IC50 of 5.2 nM, 17 nM and 13 nM for TrpA1 channel with EC50s of 97 and 23 nM, respectively. human, mouse and rat CCR2.

Purity: 99.59% Purity: 99.92% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg

PF-4878691 PF-8380 (3M-852A) Cat. No.: HY-100176 Cat. No.: HY-13344

Bioactivity: PF-4878691 is a potent and selective Toll-like receptor 7 ( Bioactivity: PF-8380 is a potent autotaxin inhibitor with an IC50 of 2.8 nM TLR7) agonist. in isolated enzyme assay and 101 nM in human whole blood.

Purity: 99.89% Purity: 98.49% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg 5 mg, 10 mg, 50 mg, 100 mg

PF-8380 hydrochloride PF06650833 Cat. No.: HY-13344A Cat. No.: HY-19836

Bioactivity: PF-8380 hydrochloride is a potent autotaxin inhibitor with an Bioactivity: PF06650833 is an inhibitor of Interleukin-1 receptor associated

IC50 of 2.8 nM in isolated enzyme assay and 101 nM in human kinase 4 (IRAK4), and used to treat diseases such as rheumatoid whole blood. arthritis, lupus, and lymphomas.

Purity: >98% Purity: 98.68% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

88 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

PGD2-IN-1 PGS-IN-1 Cat. No.: HY-101430 (KME-4) Cat. No.: HY-101587

Bioactivity: PGD2-IN-1 is an antagonist of DP extracted from patent WO Bioactivity: PGS-IN-1 is a potent inhibitor of prostaglandin synthetase

2006044732 A2, example 15 (d); has an IC50 of 0.3 nM. (PGS) with an IC50 of 0.28 μM; also inhibits 5-lipoxygenase

with an IC50 of 1.05 μM.

Purity: 98.03% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 50 mg, 100 mg

PH-797804 Cat. No.: HY-10403 (Acetophenetidin) Cat. No.: HY-B0476

Bioactivity: PH-797804 is a novel pyridinone inhibitor of p38α with IC50 of Bioactivity: Phenacetin is a non-opioid analgesic without anti-inflammatory 26 nM; 4-fold more selective versus p38β and does not inhibit properties. JNK2. IC50 value: 26 nM [1] Target: p38αMAPK in vitro: PH-797804 blocks LPS-induced TNF-α production and p38 kinase activity in the human monocytic U937 cell line, with… Purity: 98.59% Purity: 99.09% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg 1 g, 5 g

Pheniramine Maleate Cat. No.: HY-B0971 Cat. No.: HY-B0230

Bioactivity: Maleate ia an antihistamine and vasoconstrictor. Bioactivity: Phenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of , including the symptoms of arthritis.

Purity: 99.88% Purity: 98.86% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 500 mg

Phorbol 12-myristate 13-acetate Disodium (PMA) Cat. No.: HY-18739 Cat. No.: HY-N2021A

Bioactivity: Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a Bioactivity: Phosphoramidon disodium is a metalloprotease inhibitor. commonly used PKC activator. Phosphoramidon inhibits endothelin-converting enzyme ( ECE), neutral endopeptidase ( NEP), and angiotensin-converting

enzyme ( ACE) with IC50 values of 3.5, 0.034, and 78 μM, respectively. Purity: 99.08% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 1 mg, 5 mg, 10 mg 1 mg, 5 mg, 10 mg, 25 mg, 50 mg

Phytic acid (myo-, hexakis(dihydrogen phosphate); PI-3065 Inositol hexaphosphate) Cat. No.: HY-N0814 Cat. No.: HY-12235

Bioactivity: is a major phosphorus storage compound of most Bioactivity: PI-3065 is a potent inhibitor of PI3K p110δ, with IC50 and Ki seeds and cereal grains. values of 5 nM and 1.5 nM, and exhibits less potent activity

against p110α, p110β, p110γ with IC 50s of 910, 600, >10000 nM. Purity: 64.55% Purity: 98.27% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 250 mg 5 mg, 10 mg, 50 mg, 100 mg

www.MedChemExpress.com 89

PI3Kδ-IN-2 Cat. No.: HY-102031 Cat. No.: HY-B0944

Bioactivity: PI3Kδ-IN-2 is a potent and selective inhibitor of PI3Kδ Bioactivity: Pidotimod is an , a synthetic dipeptide with extracted from patent WO 2015055071 A1, compound 10; has an immunomodulatory properties, also able to increase the

IC50 of 6.4 nM. concentration of salivary IgA directed against bacteria.

Purity: 98.95% Purity: 99.36% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 100 mg, 500 mg

Pimecrolimus Piperidinylaminomethyl Trifluoromethyl Cyclic Ether Compound (SDZ-ASM 981) Cat. No.: HY-13723 1 Cat. No.: HY-U00382 Bioactivity: is an immunophilin ligand, which binds Bioactivity: Piperidinylaminomethyl Trifluoromethyl Cyclic Ether Compound 1 specifically to the cytosolic receptor, immunophilin has the potential function in central nervous system macrophilin-12. disorders, respiratory, inflammatory diseases and gastrointestinal disorders.

Purity: 98.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 10 mg, 50 mg, 100 mg

Piperine hydrochloride (Bioperine; 1-Piperoylpiperidine) Cat. No.: HY-N0144 (Benodaine hydrochloride) Cat. No.: HY-100850

Bioactivity: Piperine, a natural alkaloid isolated from Piper nigrum L, Bioactivity: Piperoxan hydrochloride is an α 2 adrenoceptor antagonist. inhibits P-glycoprotein and CYP3A4 activities with an IC50 value of 61.94±0.054 μg/mL in HeLa cell.

Purity: 98.76% Purity: 99.68% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 200 mg, 1 g, 5 g 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Pirazolac dihydrochloride (ZK-76604) Cat. No.: HY-100146 (LS519) Cat. No.: HY-17037

Bioactivity: Pirazolac is a non-steroidal anti-inflammatory drug. Bioactivity: Pirenzepine dihydrochloride (LS519) is a selective M1 muscarinic receptor antagonist.

Purity: >98% Purity: 99.60% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 100 mg, 500 mg

Pirfenidone Pirolate (AMR69) Cat. No.: HY-B0673 (CP-32387) Cat. No.: HY-100280

Bioactivity: Pirfenidone is a drug used for the treatment of idiopathic Bioactivity: Pirolate is a histamine H1 receptor. pulmonary fibrosis. It inhibits FGFR, EGFR, PDGFR, TGF-β, thereby slowing tumor cell proliferation.

Purity: 99.98% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 100 mg, 500 mg, 1 g, 5 g

90 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Piroxicam PKC-IN-1 Cat. No.: HY-B0253 Cat. No.: HY-16903

Bioactivity: is a non-steroidal anti-inflammatory drugs, acts as Bioactivity: PKC-IN-1 is a potent, ATP-competitive and reversible inhibitor

a COX inhibitor, with IC50s of 47, 25 μM for human monocyte of conventional PKC enzymes with Kis of 5.3 and 10.4 nM for

COX-1 and COX-2, respectively. human PKCβ and PKCα, and IC50s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808 nM for PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu … Purity: 99.73% Purity: 99.50% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 5 g, 10 g 5 mg, 10 mg, 50 mg, 100 mg

Plerixafor octahydrochloride (AMD3100 octahydrochloride; (AMD 3100; AMD-3329; JM3100) Cat. No.: HY-10046 JM3100 octahydrochloride; SID791 octahydrochloride) Cat. No.: HY-50912

Bioactivity: Plerixafor is a selective CXCR4 antagonist with an IC50 of 44 Bioactivity: Plerixafor octahydrochloride is a selective CXCR4 antagonist with an IC of 44 nM. nM. 50

Purity: 98.0% Purity: 98.90% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in Ethanol, Size: 10mM x 1mL in Water, 10 mg, 50 mg, 100 mg 10 mg, 50 mg, 100 mg

PLP 139-151 PLP(139-151) Cat. No.: HY-P0129 Cat. No.: HY-P1038

Bioactivity: PLP (139-151) is amino acid residue 139 to 151 of myelin Bioactivity: PLP(139-151) is a fragment of myelin proteolipid protein, proteolipid protein (PLP) used to induce experimental induce experimental autoimmune encephalomyelitis (EAE). autoimmune encephalomyelitis (EAE). Sequence: Sequence: His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe. His-Cys-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe.

Purity: 98.63% Purity: 98.25% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

PMX 205 PMX 205 Trifluoroacetate Cat. No.: HY-110136 Cat. No.: HY-110136A

Bioactivity: PMX 205 is a potent complement ( C5aR; Bioactivity: PMX 205 Trifluoroacetate is a potent complement C5a CD88) antagonist. receptor ( C5aR; CD88) antagonist.

Purity: >98% Purity: 98.89% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 500u g, 1 mg, 5 mg Size: 10mM x 1mL in DMSO, 500u g, 1 mg, 5 mg

PNF21 PNRI-299 (Prednisolone Farnesylate) Cat. No.: HY-U00169 Cat. No.: HY-15131

Bioactivity: PNF21 is a new transdermal corticosteroid with Bioactivity: PNRI-299 is a selective AP-1 transcription inhibitor with IC50 anti-inflammatory activity. of 20 uM without affecting NF-kappaB transcription (up to 200 uM) or thioredoxin (up to 200 uM). IC50 value: 20 uM [1] Target: AP-1 inhibitor in vitro: PNRI-299 specifically reacts with Ref-1, inhibits AP-1 transcription, and overexpression of… Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 5 mg

www.MedChemExpress.com 91

Polaprezinc Polydatin (Zinc L-) Cat. No.: HY-B0729 () Cat. No.: HY-N0120A

Bioactivity: Polaprezinc is an orally bioavailable chelate composed of zinc Bioactivity: Polydatin (Piceid), extracted from the roots of Polygonum and L-carnosine, with potential gastroprotective, cuspidatum Sieb, a widely used traditional Chinese anti-oxidant, anti-ulcer and anti-inflammatory activities. remedies, possesses anti-inflammatory activity in several experimental models.

Purity: 98.0% Purity: 98.42% Clinical Data: Launched Clinical Data: Phase 2 Size: 10 mg, 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 100 mg, 200 mg, 500 mg

Ponesimod PPA-904 (ACT-128800) Cat. No.: HY-10569 Cat. No.: HY-U00128

Bioactivity: Ponesimod(ACT-128800) is an orally active, selective Bioactivity: PPA-904 is a specific phenothiazine photosensitizer used in sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator. .

Purity: 99.53% Purity: >98% Clinical Data: Phase 3 Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 50 mg, 100 mg

Pranlukast (ONO-1078) Cat. No.: HY-B0290 Cat. No.: HY-B0336

Bioactivity: is a highly potent, selective and competitive Bioactivity: Pranoprofen is a non-steroidal anti-inflammatory drug used in antagonist of peptide leukotrienes. Pranlukast inhibits [ ophthalmology. 3 3 3 H]LTE 4, [ H]LTD 4, and [ H]LTC 4 bindings to lung

membranes with Kis of 0.63±0.11, 0.99±0.19, and 5640±680 … Purity: 98.0% Purity: 98.48% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 100 mg, 500 mg

Prednisolone 21-acetate Prednisolone disodium phosphate Cat. No.: HY-B1214 (Prednisolone 21-phosphate disodium) Cat. No.: HY-B0645

Bioactivity: Prednisolone 21-acetate is an adrenal cortico hormones, with Bioactivity: Prednisolone disodium phosphate is a synthetic glucocorticoid anti-inflammatory, anti-allergic and immune suppressive with anti-inflammatory and immunomodulating properties. effects. Target: Glucocorticoid Receptor Prednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity. Prednisolone can activate and… Purity: 98.0% Purity: 98.37% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 250 mg, 500 mg 100 mg, 500 mg

Prednisolone hemisuccinate (Prednisolone 21-hemisuccinate) Cat. No.: HY-B1087 Cat. No.: HY-U00098

Bioactivity: Prednisolone hemisuccinate is a synthetic glucocorticoid, a Bioactivity: Prednisolone tebutate is a synthetic glucocorticoid used as an derivative of cortisol, which is used to treat a variety of antiinflammatory and immunosuppressant. inflammatory and auto-immune conditions.

Purity: >98% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 100 mg Size: 5 mg

92 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Prednisone Prim-O-glucosylcimifugin (Dehydrocortisone) Cat. No.: HY-B0214 Cat. No.: HY-N0635

Bioactivity: (Adasone) is a synthetic corticosteroid agent that Bioactivity: Prim-O-glucosylcimifugin exerts anti-inflammatory effects is particularly effective as an immunosuppressant compound. through the inhibition of iNOS and COX-2 expression by through Target: Others Prednisone is a synthetic corticosteroid drug regulating JAK2/STAT3 signaling. that is particularly effective as an immunosuppressant drug. It is used to treat certain inflammatory diseases (such as… Purity: 99.35% Purity: 99.76% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg 1 g, 5 g

PRN694 Cat. No.: HY-12680 (4-Isopropylantipyrine; Isopropylphenazone) Cat. No.: HY-A0273

Bioactivity: PRN694 is a highly selective and potent covalent inhibitor of Bioactivity: Propyphenazone is a derivative with T cell kinase ( ITK) and resting lymphocyte kinase ( RLK) with anti-inflammatory, analgesic and antipyretic activity,

IC50s of 0.3 and 1.4 nM, respectively. Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.

Purity: 99.44% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg 250 mg

Protease-Activated Receptor-2 Activating Peptide Protirelin (Synthetic thyrotropin-releasing factor; Synthetic Cat. No.: HY-P1308 thyrotropin-releasing hormone; TRF; TRH; TSH-RF; …) Cat. No.: HY-P0002

Bioactivity: Protease-Activated Receptor-2 Activating Peptide is an agonist Bioactivity: Protirelin is a highly conserved that exerts the of Protease-Activated Receptor-2 ( PAR-2). hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Phase 3 Size: 5 mg, 10 mg Size: 10 mg

Protirelin Acetate PRT062607 (TRF Acetate; TRH Acetate; TSH-RF Acetate) Cat. No.: HY-P0002A (P505-15; PRT-2607; BIIB-057) Cat. No.: HY-15322

Bioactivity: Protirelin Acetate is a highly conserved neuropeptide that Bioactivity: PRT062607(P505-15; PRT-2607; BIIB-057) is a highly specific exerts the hormonal control of thyroid-stimulating hormone and potent inhibitor of Syk with IC50 of 1-2 nM; >80-fold (TSH) levels as well as neuromodulatory functions. selective for Syk than Fgr, Lyn, FAK, Pyk2 and Zap70.

Purity: 99.58% Purity: >98% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 50 mg 10 mg, 50 mg, 100 mg

Puerarin Pumaprazole Cat. No.: HY-N0145 (BY-841) Cat. No.: HY-19223

Bioactivity: , an isoflavone extracted from Radix puerariae, is a Bioactivity: Pumaprazole is a reversible proton pump antagonist. 5-HT2C receptor antagonist.

Purity: 98.14% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 10 mg, 50 mg, 100 mg

www.MedChemExpress.com 93

Purpureaside C Pyributicarb Cat. No.: HY-N4148 (TSH-888) Cat. No.: HY-111202

Bioactivity: Purpureaside C is a phenolic glycoside and has significant Bioactivity: Pyributicarb, a carbamate-type herbicide, is a potent proinflammatory action. activator of both CYP3A4 gene and human pregnane X receptor ( hPXR).

Purity: 98.0% Purity: 99.99% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 50 mg

Pyrrolifene QL9 Cat. No.: HY-U00081 Cat. No.: HY-P0287

Bioactivity: Pyrrolifene is an analgesic with anti-inflammatory effect. Bioactivity: QL9 (QLSPFPFDL) is a high-affinity alloantigen for the 2C T cell receptor (TCR). Sequence: Gln-Leu-Ser-Pro-Phe-Pro-Phe-Asp-Leu.

Purity: >98% Purity: 98.49% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg

QNZ Quadrol (EVP4593) Cat. No.: HY-13812 (N,N,N′,N′-Tetrakis(2-hydroxypropyl)ethylenediamine; EDTP) Cat. No.: HY-B2149

Bioactivity: QNZ shows strong inhibitory effects on NF-κB transcriptional Bioactivity: Quadrol is an immunostimulant and has been implicated as a potentially useful agent in accelerated wound healing. activation and TNF-α production with IC50s of 11 and 7 nM, respectively. EVP4593 is a neuroprotective inhibitor of SOC channel.

Purity: 98.46% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 10 g

Quercitrin Quinolinic acid ( 3-rhamnoside) Cat. No.: HY-N0418 Cat. No.: HY-100807

Bioactivity: Quercitrin is a natural compound found in Tartary buckwheat Bioactivity: Quinolinic acid is an endogenous N-methyl-D-aspartate receptor with a potential anti-inflammation effect that is used to agonist synthesized from L-tryptophan via the kynurenine treat heart and vascular conditions. IC50 value: Target: In pathway and thereby has the potential of mediating vitro: There were significant increases in caspase-3 activity, N-methyl-D-aspartate neuronal damage and dysfunction. loss of MMP, and increases in the apoptotic cell population in… Purity: 98.27% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 1 g

Quinotolast sodium R112 (FR71021) Cat. No.: HY-U00027 Cat. No.: HY-16420

Bioactivity: Quinotolast sodium in the concentration range of 1-100 μg/mL Bioactivity: R112 is an ATP-competitive inhibitor of Syk kinase with a Ki

inhibits histamine, LTC4 and PGD2 release in a of 96 nM. R112 inhibits Syk kinase activity with an IC50 of concentration-dependent manner. 226 nM.

Purity: >98% Purity: 99.95% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

94 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

R406 free base R788 Cat. No.: HY-11108 (Fostamatinib) Cat. No.: HY-13038A

Bioactivity: R406 is a potent Syk inhibitor with IC50 of 41 nM, strongly Bioactivity: R788 (Fostamatinib), a prodrug of the active metabolite R406, inhibits Syk but not Lyn, 5-fold less potent to Flt3. IC50 is a potent Syk inhibitor with IC50 of 41 nM. IC50 Value: 41 value: 41 nM [1] Target: Syk in vitro: R406 is a potent nM [1] Target: Syk in vitro: R788 is a methylene phosphate inhibitor of immunoglobulin E (IgE)- and IgG-mediated prodrug of R406, which can be rapidly converted to R406 in activation of Fc receptor signaling. R406 inhibits the… vivo. R406 (in vitro active form of R788) selectively inhibits… Purity: 99.25% Purity: >98% Clinical Data: No Development Reported Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

R788 disodium hexahydrate R788(Disodium) (Fostamatinib disodium hexahydrate) Cat. No.: HY-13038B (Fostamatinib Disodium) Cat. No.: HY-13038

Bioactivity: R788 sodium salt hydrate (Fostamatinib), a prodrug of the Bioactivity: R788 (Fostamatinib) disodium, a prodrug of the active active metabolite R406, is a potent Syk inhibitor with IC50 of metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM. 41 nM. IC50 Value: 41 nM [1] Target: Syk in vitro: R788 is a IC50 Value: 41 nM [1] Target: Syk in vitro: R788 is a methylene phosphate prodrug of R406, which can be rapidly methylene phosphate prodrug of R406, which can be rapidly converted to R406 in vivo. R406 (in vitro active form of R788)… converted to R406 in vivo. R406 (in vitro active form of R788)… Purity: 98.87% Purity: 98.79% Clinical Data: Phase 3 Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

Rabeprazole Rabeprazole sodium (LY307640) Cat. No.: HY-B0656 (LY307640 sodium) Cat. No.: HY-B0656A

Bioactivity: Rabeprazole is an antiulcer drug in the class of proton pump Bioactivity: Rabeprazole sodium(LY307640 sodium) is an antiulcer drug in inhibitors. the class of proton pump inhibitors.

Purity: >98% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 10 mg, 50 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg

Ramatroban Ramifenazone (BAY u3405) Cat. No.: HY-B0745 (Isopropylaminoantipyrine) Cat. No.: HY-B1137

Bioactivity: Ramatroban is a selective thromboxane A2 ( TxA2, Bioactivity: Ramifenazone is a nonsteroidal anti-inflammatory drug.

IC50=14 nM) antagonist, which also antagonizes CRTH2 (

IC50=113 nM) by inhibiting PGD2 binding.

Purity: 99.16% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg 10 mg, 50 mg, 100 mg

RD20000 ReN-1869 hydrochloride ( propionate) Cat. No.: HY-U00190 (NNC-05-1869 hydrochloride) Cat. No.: HY-101724

Bioactivity: RD20000 is a corticosteroid which is obtained by esterifying Bioactivity: ReN 1869 hydrochloride is a novel, selective histamine H1 with propionic acid the 17-position of the prednisolone receptor antagonist, which demonstrates affinity to the skeleton and deoxidating its 21-position. histamine H 1 receptor (guinea pig brain) with K i of 0.19±0.04 μM and the non-selective σ site (guinea pig bra… Purity: >98% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

www.MedChemExpress.com 95

Reparixin Reparixin L-lysine salt (Repertaxin; DF 1681Y) Cat. No.: HY-15251 (Repertaxin L-lysine salt) Cat. No.: HY-15252

Bioactivity: Reparixin is a non-competitive allosteric inhibitor of the Bioactivity: Reparixin L-lysine salt is an allosteric inhibitor of

chemokine receptors CXCR1 and CXCR2 activation with IC50s of chemokine receptor 1/2 (CXCR1/2) activation. 1 and 100 nM, respectively.

Purity: 99.88% Purity: 98.44% Clinical Data: Phase 3 Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg 5 mg, 10 mg, 50 mg

Resatorvid Resiquimod (TAK-242; CLI-095) Cat. No.: HY-11109 (R848; S28463) Cat. No.: HY-13740

Bioactivity: TAK-242 (Resatorvid) is a potent TLR4 signaling inhibitor Bioactivity: Resiquimod is a Toll-like receptor 7 and 8 ( TLR7/TLR8) which selectively inhibits the TLR4-mediated production of agonist that induces the upregulation of cytokines such as cytokines and nitric oxide. TNF-α, IL-6 and IFN-α.

Purity: 99.95% Purity: 99.82% Clinical Data: Phase 3 Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 10 mg, 25 mg, 50 mg, 100 mg

Resorcinol monoacetate (Resorcin; 1,3-Benzenediol) Cat. No.: HY-B0907 (Acetylresorcinol; Resorcin monoacetate) Cat. No.: HY-B0894

Bioactivity: Resorcinol is an and a disinfectant, and a chemical Bioactivity: Resorcinol monoacetate is an antiseptic and a disinfectant, is intermediate for the production of many other a chemical intermediate for the production of many other pharmaceuticalsis used to treat acne, seborrheic dermatitis, pharmaceuticals, and can be used to treat acne, seborrheic eczema, psoriasis, and other skin disorders. dermatitis, eczema, psoriasis, and other skin disorders.

Purity: 99.96% Purity: 62.40% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 100 mg

Resveratrol (trans-) Cat. No.: HY-16561 (Vitamin A1; all-trans-Retinol) Cat. No.: HY-B1342

Bioactivity: Resveratrol, a natural polyphenol that possesses anti-oxidant, Bioactivity: Retinol, also known as Vitamin A1, has pleiotropic functions anti-inflammatory, cardioprotective, and anti-cancer including vison, immunity, hematopoiesis, reproduction, cell properties. It has a wide spectrum of targets including differentiation/growth, and development. mTOR, JAK, β-amyloid.

Purity: 98.90% Purity: Clinical Data: Phase 4 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 200 mg, 500 mg 100 mg

Revefenacin RGX-104 (TD-4208; GSK1160724) Cat. No.: HY-15851 Cat. No.: HY-111498

Bioactivity: (TD-4208; GSK1160724) is a potent mAChR Bioactivity: RGX-104 is a small-molecule LXR agonist that modulates innate

antagonist; has a high affinity on M3 receptor with a Ki of immunity via transcriptional activation of the ApoE gene. 0.18 nM

Purity: 99.62% Purity: >98% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 2 mg, 5 mg, 10 mg, 50 mg, 100 mg

96 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

RIPA-56 RISARESTAT Cat. No.: HY-101032 (CT 112) Cat. No.: HY-16433

Bioactivity: RIPA-56 is a highly potent, selective, and metabolically Bioactivity: RISARESTAT (CT-112), an aldose reductase inhibitor, is stable inhibitor of receptor-interacting protein 1 ( RIP1) with developed for the treatment of diabetic complications.

an IC50 of 13 nM.

Purity: 99.86% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 10 mg, 50 mg, 100 mg, 200 mg

RK-24466 RN486 (KIN 001-51) Cat. No.: HY-108318 Cat. No.: HY-18018

Bioactivity: RK-24466 (KIN 001-51) is a potent and selective Lck Bioactivity: RN486 is a selective Btk inhibitor with an IC50 Value of 4.0 nM. inhibitor; inhibits Lck (64-509) and LckCD isoforms with IC50s of less than 1 and 2 nM, respectively.

Purity: 89.21% Purity: 99.38% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg 1 mg, 5 mg, 10 mg, 25 mg, 50 mg

Ro 31-9790 Ro-24-0238 (GI4747) Cat. No.: HY-101703 Cat. No.: HY-19084

Bioactivity: Ro 31-9790 is a synthetic metalloproteinase ( MMP) Bioactivity: Ro-24-0238 is an antagonist of platelet activating factor inhibitor. (PAF) and inhibitor of thromboxane synthesis, used for lessening the inflammation and damage resulting from a local release of PAF.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg

RO1138452 RO9021 (CAY10441) Cat. No.: HY-108912 Cat. No.: HY-16902

Bioactivity: RO1138452 is a potent and selective IP ( ) receptor Bioactivity: RO9021 is an orally bioavailable, novel ATP-competitive

antagonist. RO1138452 displays high affinity for IP receptors. inhibitor of SYK, with an average IC50 of 5.6 nM. In human platelets, pKi is 9.3±0.1; in a recombinant IP

receptor system, pKi is 8.7±0.06. Purity: 98.21% Purity: 99.56% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

ROCK-IN-1 ROCK2-IN-2 Cat. No.: HY-U00351 Cat. No.: HY-103620

Bioactivity: ROCK-IN-1 is a potent inhibitor of ROCK, with an IC50 of 1.2 Bioactivity: ROCK2-IN-2 is a selective ROCK2 inhibitor extracted from patent US20180093978A1, Compound A-30, has an IC of <1 nM for ROCK2. 50 μM.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 250 mg, 500 mg

www.MedChemExpress.com 97

Rofecoxib (MK 966) Cat. No.: HY-17372 Cat. No.: HY-15455

Bioactivity: is a potent, specific and orally active COX-2 Bioactivity: Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, inhibitor, with IC s of 26 and 18 nM for human COX-2 in human 50 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, osteosarcoma cells and Chinese hamster ovary cells, with a respectively, without affecting PDE1, PDE2, PDE3 or PDE5

1000-fold selectivity for COX-2 over human COX-1 (IC 50 &… isoenzymes from various cells. Purity: 99.95% Purity: 99.97% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 5 mg, 10 mg, 50 mg

Roflumilast Impurity E Roflumilast N-oxide Cat. No.: HY-100640 Cat. No.: HY-100639

Bioactivity: Roflumilast Impurity E is the impurity of Roflumilast. Bioactivity: Roflumilast N-oxide is a PDE type 4 inhibitor. Roflumilast(Daliresp) is a drug which acts as a selective and

long-acting inhibitor of the enzyme PDE-4 with an IC50 value of 0.8 nM.

Purity: >98% Purity: 99.69% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg

Roquinimex ROR gamma-t-IN-1 (Linomide; FCF89; LS2616; ABR212616; PNU212616) Cat. No.: HY-13743 Cat. No.: HY-12776

Bioactivity: Roquinimex (Linomide; PNU212616; ABR212616) is a Bioactivity: RORγt-IN-1 is a potent, orally bioavailable RORγγ Inhibitor derivative immunostimulant which increases NK cell activity with pIC50 of 8.4 and >8.2 for RORγ FRET assay and Th17 and macrophage cytotoxicity; inhibits angiogenesis and reduces assay. the secretion of TNF alpha. IC50 value: Target: TNF alpha Prophylactic administration of DSS-treated mice with… Purity: 98.88% Purity: 98.05% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 5 mg, 10 mg, 50 mg, 100 mg

RORγ-IN-1 Rosiglitazone Cat. No.: HY-103637 (BRL49653) Cat. No.: HY-17386

Bioactivity: RORγ-IN-1 is a RORγ inhibitor extracted from patent US Bioactivity: Rosiglitazone (BRL49653) is a potent thiazolidinedione insulin sensitizer. Rosiglitazone is a selective PPARγ agonist with 9481674 B1, has a Ki of <100 nM. EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively.

Purity: >98% Purity: 99.21% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 25 mg Size: 10mM x 1mL in DMSO, 50 mg, 200 mg

Rosiglitazone maleate Rosmanol (BRL 49653C) Cat. No.: HY-14600 Cat. No.: HY-N5015

Bioactivity: Rosiglitazone maleate is a potent and selective activator of Bioactivity: Rosmanol could inhibit the oxidation of low density

PPARγ, with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, lipoprotein (LPL) and significantly inhibit lipopolysaccharide PPARγ2, and PPARγ, respectively, and a K of appr 40 nM induced iNOS and COX-2 expression, with anti-inflammatory d effect. for PPARγ; Rosiglitazone maleate is also an modulator of … Purity: 99.25% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 25 mg 100 mg, 500 mg

98 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Rosmarinic acid racemate Rovazolac Cat. No.: HY-N2336 Cat. No.: HY-109073

Bioactivity: racemate is the racemate of Rosmarinic acid. Bioactivity: Rovazolac is a liver x receptor (LXR) modulator extracted from Rosmarinic acid inhibits MAO-A, MAO-B and COMT patent WO2013130892A1.

enzymes with IC50s of 50.1, 184.6 and 26.7 μM, respectively.

Purity: 98.01% Purity: 99.82% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 50 mg, 100 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

Roxatidine Acetate Hydrochloride RP-54745 (HOE 760) Cat. No.: HY-B0305A Cat. No.: HY-101716

Bioactivity: HCl is a specific and competitive histamin Bioactivity: RP 54745 is an inhibitor of macrophage stimulation and H2 receptor antagonist. interleukin-1 production, and a potential antirheumatic compound.

Purity: 98.87% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 1 g, 5 g

RS 504393 RS-601 Cat. No.: HY-15418 Cat. No.: HY-U00072

Bioactivity: RS 504393 is a selective CCR2 chemokine receptor antagonist ( Bioactivity: RS-601 is a novel leukotriene D4 (LTD4)/thromboxane A2 (TxA2)

IC50 values are 89 nM and > 100 μM for inhibition of human dual receptor antagonist, with antiasthmatic activities. recombinant CCR2 and CCR1 receptors respectively).

Purity: 98.58% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 5 mg, 10 mg, 25 mg, 50 mg

RS4317 RTA-408 (Lonapalene) Cat. No.: HY-U00156 (Omaveloxolone) Cat. No.: HY-12212

Bioactivity: RS4317 is a topically effective 5-lipoxygenase ( 5-LO) Bioactivity: RTA-408 is an antioxidant inflammation modulator (AIM), which inhibitor. activates Nrf2 and suppresses nitric oxide (NO).

Purity: >98% Purity: 98.96% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg

Rupatadine Fumarate (UR-12592) Cat. No.: HY-13511 Cat. No.: HY-13511A

Bioactivity: Rupatadine (UR-12592) is a potent dual PAF/H1 antagonist with Bioactivity: Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual Ki of 0.55/0.1 uM(rabbit platelet membranes/guinea pig PAF/H1 antagonist with Ki of 0.55/0.1 uM(rabbit platelet cerebellum membranes). membranes/guinea pig cerebellum membranes). IC50 value: Target: PAF/H1 antagonist in vitro: Rupatadine competitively inhibited histamine-induced guinea pig ileum contraction (pA2… Purity: >98% Purity: 99.34% Clinical Data: Launched Clinical Data: Launched Size: 100 mg, 500 mg Size: 10mM x 1mL in DMSO, 100 mg, 500 mg

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Rutaecarpine Rutin (Rutecarpine) Cat. No.: HY-N0147 (Rutoside; Quercetin 3-O-rutinoside) Cat. No.: HY-N0148

Bioactivity: Rutaecarpine, an alkaloid of Evodia rutaecarpa, is an inhibitor Bioactivity: Rutin, a naturally occurring flavonoid glycoside, has

of COX-2 with an IC50 value of 0.28 μM. antioxidant, anti-inflammatory, anti-allergic, anti-angiogenic and antiviral properties.

Purity: 99.11% Purity: 98.67% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 5 g, 10 g

RVT-501 RWJ 63556 (E6005; lotamilast) Cat. No.: HY-12740 Cat. No.: HY-U00022

Bioactivity: RVT-501 (E6005) is a selective phosphodiesterase 4 ( PDE4) Bioactivity: RWJ 63556 is an orally active COX-2 selective/5-lipoxygenase

inhibitor with an IC50 of 2.8 nM. inhibitor, with anti-inflammatory activities.

Purity: 98.0% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 50 mg, 100 mg

S-(+)-Ketoprofen S-2474 ((S)-Ketoprofen; ) Cat. No.: HY-B2137 Cat. No.: HY-19212

Bioactivity: S-(+)-Ketoprofen is a potent inhibitor of both COX-1 and Bioactivity: S-2474 is an inhibitor of COX-2 and 5-lipoxygenase, and used

COX-2 with IC50s of 1.9 and 27 nM, respectively. as a nonsteroidal anti-inflammatory drug.

Purity: 99.95% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 100 mg

S-Allyl-L-cysteine S-methyl-KE-298 Cat. No.: HY-W013573 (M-2) Cat. No.: HY-101671

Bioactivity: S-Allyl-L-cysteine, one of the organosulfur compounds found in Bioactivity: S-methyl-KE-298 is an active metabolite of KE-298. KE-298 AGE, possess various biological effects including neurotrophic inhibits matrix metalloproteinase (MMP-1) production from activity, anti-cancer activity, anti-inflammatory activity. rheumatoid arthritis (RA) synovial cells.

Purity: 98.64% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 10 mg, 25 mg, 50 mg, 100 mg

S1p receptor agonist 1 S1P1 Agonist III Cat. No.: HY-101265 Cat. No.: HY-12835

Bioactivity: S1p receptor agonist 1 is an S1P receptor agonist extracted Bioactivity: S1P1 Agonist III is a potent and orally active S1P1 agonist from patent WO 2015039587 A1, compound example 2. with EC50 of 18 nM; no activity on S1P3.

Purity: 98.28% Purity: 98.46% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

100 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

S1PR1-MO-1 S3337 Cat. No.: HY-U00366 Cat. No.: HY-U00222

Bioactivity: S1PR-MO-1 is the modulator of sphingosine-1-phosphate Bioactivity: S3337 is an H +, K +-ATPase inhibitor. receptor, used for research of hyperproliferative, inflammatory diseases.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

Saikogenin A Saikosaponin D Cat. No.: HY-N6584 Cat. No.: HY-N0250

Bioactivity: Saikogenin A, extracted from a Chinese herbal plant called Bioactivity: Saikosaponin D is a triterpene saponin isolated from Tsai-Fu, is a dipeptidyl peptidase-IV ( DPP-IV) inhibitor. Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; Saikosaponin D inhibits selectin, STAT3 and NF-kB and activates estrogen receptor-β.

Purity: 98.31% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Salbutamol hemisulfate Cat. No.: HY-B0436 (D-(−)-Salicin; Salicoside) Cat. No.: HY-N0149

Bioactivity: Salbutamol Hemisulfate is a short-acting β2 adrenergic Bioactivity: Salicin is a natural COX inhibitor. receptor agonist Target: β2 Adrenergic Receptor Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. All the effects of R,S-salbutamol on guinea-pig skeletal muscles are due to the… Purity: 98.0% Purity: 99.60% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 500 mg, 1 g, 5 g

Salicylamide (2-Hydroxybenzamide) Cat. No.: HY-B0811 (2-Hydroxybenzoic acid) Cat. No.: HY-B0167

Bioactivity: is an inhibitor of microsomal Bioactivity: Salicylic acid inhibits cyclo-oxygenase-2 ( COX-2) activity UDP-glucuronosyltransferase. Salicylamide is an analgesic and independently of transcription factor (NF-κB) activation. anti-pyretic agent.

Purity: 99.58% Purity: 98.0% Clinical Data: Launched Clinical Data: Launched Size: 1 g, 10 g Size: 10mM x 1mL in DMSO, 10 g, 50 g

Salmeterol xinafoate (GR 33343X xinafoate) Cat. No.: HY-17453 (Salicylsalicylic acid; Disalicylic acid) Cat. No.: HY-B1245

Bioactivity: xinafoate is a long-acting beta-2 adrenergic Bioactivity: Salsalate is a nonsteroidal anti-inflammatory drug (NSAID).

receptor ( β2AR) agonist, with Ki of 1.5 nM for WT β 2AR, and used for asthma treatment.

Purity: 97.66% Purity: 99.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg, 200 mg 100 mg

www.MedChemExpress.com 101

Salvianolic acid A SAR-100842 Cat. No.: HY-N0318 Cat. No.: HY-100185

Bioactivity: Salvianolic acid A could protect the blood brain barrier Bioactivity: SAR-100842 is a lysophaphatidic acid 1 ( LPA1/ Edg-2) through matrix metallopeptidase 9 (MMP-9) inhibition and receptor inhibitor. anti-inflammation.

Purity: 99.26% Purity: 99.69% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg 1 mg, 5 mg, 10 mg

Sarsasapogenin SB 203580 (Parigenin; Sarsagenin) Cat. No.: HY-N0073 (RWJ 64809) Cat. No.: HY-10256

Bioactivity: Sarsasapogenin is a sapogenin from the Chinese medical herb Bioactivity: SB 203580 is a widely used p38 MAPK inhibitor with an IC50 Anemarrhena asphodeloides Bunge, with antidiabetic, of 0.3-0.5 μM. It shows more than 100-fold selectivity over anti-oxidative, anticancer and anti-inflamatory activities. PKB, LCK, and GSK-3β.

Purity: 99.20% Purity: 99.54% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 25 mg, 50 mg, 100 mg 10 mg, 50 mg, 100 mg, 200 mg

SB 203580 hydrochloride SB 239063 (RWJ 64809 hydrochloride) Cat. No.: HY-10256A Cat. No.: HY-11068

Bioactivity: SB 203580 hydrochloride is a widely used p38 MAPK Bioactivity: SB 239063 is a potent and selective p38 MAPK inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity inhibitor with an IC50 of 0.3-0.5 μM. It shows more than 100-fold selectivity over PKB, LCK, and GSK-3β. over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. IC50 value: 44 nM ( p38α) Target: p38 MAPK SB 239063 reduces inflammatory cytokine production and is… Purity: 99.71% Purity: 99.53% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg, 200 mg 5 mg, 10 mg, 50 mg

SB225002 SB290157 trifluoroacetate Cat. No.: HY-16711 Cat. No.: HY-101502A

Bioactivity: SB225002 is a potent and selective CXCR2 antagonist with an Bioactivity: SB290157 trifluoroacetate is a potent and selective C3a

IC50 of 22 nM. receptor antagonist with an IC50 of 200 nM.

Purity: 99.58% Purity: 99.45% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

SC57666 SC58451 Cat. No.: HY-U00129 Cat. No.: HY-U00239

Bioactivity: SC57666 is a selective COX2 inhibitor with an IC50 of 26 nM. Bioactivity: SC58451 is a potent and selective Cox-2 inhibitor with an IC50 of 1.1 nM.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

102 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

SCH 546738 SCH 563705 Cat. No.: HY-10017 Cat. No.: HY-10011

Bioactivity: SCH 546738 is a novel, potent and non-competitive CXCR3 Bioactivity: SCH 563705 is a potent and orally available CXCR2 and CXCR1

antagonist, the affinity constant ( Ki) of SCH 546738 binding antagonist, with IC50s of 1.3 nM, 7.3 nM and Kis of 1 and 3 to human CXCR3 receptor is determined to be 0.4 nM in multiple nM, respectively. experiments.

Purity: 99.20% Purity: 95.34% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 2 mg, 5 mg, 10 mg

Schisandrin (Schizandrol; Schizandrol-A; Wuweizi alcohol-A; Schisandrin A Wuweizichun-A) Cat. No.: HY-N0691 (Schizandrin-A; Wuweizisu-A; Deoxyschizandrin) Cat. No.: HY-N0693

Bioactivity: Schisandrin has various therapeutic effects on a range of Bioactivity: Schisandrin A inhibits CYP3A activity with an IC50 of 6.60 μM medical conditions such as anti-asthmatic, anti-cancer, and and K of 5.83 μM, respectively. anti-inflammatory effects. IC50 value: Target: in vitro: Sch i inhibited the pro-fibrotic activity of TGF-β1 in AML12 cells; thus, it suppressed the accumulation of ECM proteins. Also,… Purity: 99.62% Purity: 99.88% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 10 mg

Schisantherin A Scopoletin (Gomisin-C; Schizantherin-A; Wuweizi ester-A) Cat. No.: HY-N0694 (Gelseminic acid; Chrysatropic acid) Cat. No.: HY-N0342

Bioactivity: Schisantherin A is a dibenzocyclooctadiene lignan isolated Bioactivity: Scopoletin is an inhibitor of acetylcholinesterase ( AChE). from the fruit of Schisandra sphenanthera. Schisantherin A inhibits p65-NF-κB translocation into the nucleus by IκBα degradation.

Purity: 99.69% Purity: 99.57% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 50 mg, 100 mg, 200 mg

Scutellarein SD 0006 (6-Hydroxyapigenin; 4',5,6,7-Tetrahydroxyflavone) Cat. No.: HY-N0752 (SD-06) Cat. No.: HY-11087

Bioactivity: Scutellarin, a main active ingredient extracted from Erigeron Bioactivity: SD-06 is a p38 MAP kinase inhibitor; inhibits p38α with an breviscapus (Vant.) Hand-Mazz., has been wildly used to treat IC50 value of 170 nM and inhibits LPS-stimulated TNF-release acute cerebral infarction and paralysis induced by in rats (83% inhibition at 1mg/kg, po). IC50 value: 170 nM cerebrovascular diseases. Target: p38MAPK

Purity: 98.15% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg 5 mg

SDMA Secalciferol (Symmetric dimethylarginine; NG,NG'-Dimethyl-L-arginine) Cat. No.: HY-101410 ((24R)-24,25-Dihydroxyvitamin D3) Cat. No.: HY-32343

Bioactivity: SDMA (Symmetric dimethylarginine) is an endogenous inhibitor Bioactivity: Secalciferol is a metabolite of Vitamin D, a possibly of nitric oxide ( NO) synthase activity. anti-inflammatory steroid which is involved in bone ossification.

Purity: 98.0% Purity: 98.58% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg 10 mg, 25 mg, 50 mg, 100 mg

www.MedChemExpress.com 103

Seco Rapamycin sodium salt , porcine (Secorapamycin A monosodium) Cat. No.: HY-19555A (Porcine secretin acetate) Cat. No.: HY-P1535

Bioactivity: Seco Rapamycin sodium salt is the ring-opened product of Bioactivity: Secretin, porcine is a 27-amino acid peptide, acting on Rapamycin. Seco-rapamycin is reported not to affect the mTOR pancreatic acinar cells and ductal epithelial cells function. stimulating the production of bicarbonate rich fluid.

Purity: 87.02% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg 1 mg, 5 mg, 10 mg, 25 mg, 50 mg

Seletalisib (UCB5857) Cat. No.: HY-16754 (AA 2414) Cat. No.: HY-B0774

Bioactivity: Seletalisib (UCB5857) is potent and selective PI3Kδ inhibitor Bioactivity: Seratrodast(AA 2414) is a potent and selective thromboxane A2 receptor (TP) antagonist. with an IC50 of 12 nM.

Purity: 99.59% Purity: 98.12% Clinical Data: Phase 2 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 10 mg, 50 mg

Sertaconazole nitrate (FI7056) Cat. No.: HY-B0736A (ACT-129968; KYTH-105) Cat. No.: HY-16635

Bioactivity: Sertaconazole nitrate is a topical broad-spectrum antifungal Bioactivity: Setipiprant is an orally available, selective CRTH2 that is developed to provide an additional agent for the antagonist. CRTH2 is a -coupled receptor for PGD2. treatment of superficial cutaneous and mucosal infections.

Purity: 96.97% Purity: 98.17% Clinical Data: Launched Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg

Sinomenine hydrochloride SK1-IN-1 (Cucoline hydrochloride) Cat. No.: HY-15122A Cat. No.: HY-101805

Bioactivity: Sinomenine hydrochloride is a blocker of the NF-κB activation Bioactivity: SK1-IN-1 is a potent sphingosine kinase 1 ( SPHK1) inhibitor

and also an activator of μ-opioid receptor. with an IC50 of 58 nM.

Purity: 98.0% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Skepinone-L SKF-86002 (Skepinone L) Cat. No.: HY-15300 Cat. No.: HY-12511

Bioactivity: Skepinone-L is a selective p38 mitogen-activated protein Bioactivity: SKF-86002 is a potent inhibitor of p38 MAP kinase wit IC50 of kinase inhibitor. 0.5-1 uM; inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM).

Purity: 99.63% Purity: 99.51% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 5 mg, 10 mg, 50 mg

104 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

SM 16 Sodium gualenate Cat. No.: HY-111482 (Guaiazulenesulfonate sodium) Cat. No.: HY-B2191

Bioactivity: SM 16 is a ALK5/ALK4 kinase inhibitor with Kis of 10 and 1.5 Bioactivity: Sodium gualenate (Guaiazulenesulfonate sodium) is a nM, respectively. hydrophilic derivative of guaiazulene with excellent anti-inflammatory and wound-healing effects mainly used for the treatment of duodenal ulcer, gastric ulcer and gastritis.

Purity: >98% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 100 mg

Sodium Salicylate (Salicylic acid sodium salt; Sofalcone 2-Hydroxybenzoic acid sodium salt) Cat. No.: HY-B0167A Cat. No.: HY-B2184

Bioactivity: inhibits cyclo-oxygenase-2 ( COX-2) Bioactivity: Sofalcone, a gastric antiulcer agent in clinical use, is known activity independently of transcription factor (NF-κB) to induce the expression of Heme oxygenase-1 ( HO-1) in activation. gastric .

Purity: 99.93% Purity: 98.89% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 10 g, 50 g 100 mg, 500 mg, 1 g, 5 g

Solcitinib Sophoricoside (GSK-2586184; GLPG-0778) Cat. No.: HY-16755 Cat. No.: HY-N0423

Bioactivity: Solcitinib is an orally active, competitive, potent, selective Bioactivity: Sophoricoside is an isoflavone glycoside isolated from Sophora

JAK1 inhibitor, with an IC50 of 9.8 nM, and 11-, 55- and japonica and has anti-inflammatory, anti-cancer and 23-fold selectivity over JAK2, JAK3 and TYK2, respectively; immunosuppressive effects. Solcitinib is used in the research of moderate-to-severe plaque-type psoriasis. Purity: 99.42% Purity: 98.93% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg 10 mg, 50 mg, 100 mg

Sotrastaurin Spirofylline (AEB071) Cat. No.: HY-10343 Cat. No.: HY-100250

Bioactivity: Sotrastaurin is a potent pan- PKC inhibitor, with Kis of 0.22 Bioactivity: Spirofylline is a bronchodilator, which can be used to treat nM, 0.64nM, 0.95 nM, 1.8 nM, 2.1 nM and 3.2 nM for PKCθ, PKCβ, asthma and bronchitis and emphysema. PKCα, PKCη, PKCδ and PKCε, respectively.

Purity: 99.70% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 5 mg, 10 mg, 50 mg

SR-31747 SR0987 Cat. No.: HY-13751A Cat. No.: HY-101454

Bioactivity: SR-31747 is a new sigma ligand with immunosuppressive Bioactivity: SR0987 is a RORγt agonist, with an EC50 of 800 nM. properties.

Purity: >98% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

www.MedChemExpress.com 105

SR1001 SR121566A Cat. No.: HY-13421 Cat. No.: HY-U00235

Bioactivity: SR1001 is a selective RORα and RORγ inverse agonist; Bioactivity: SR121566A is a novel non-peptide Glycoprotein IIb/IIIa ( GP IIb-IIIa) antagonist, which can inhibit ADP-, arachidonic acid- inhibits T H17 cell differentiation and function. and collagen-induced human platelet aggregation with IC50s of 46±7.5, 56±6 and 42±3 nM, respectively.

Purity: 99.79% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 50 mg

SR2211 SRT3109 Cat. No.: HY-16998 Cat. No.: HY-15462

Bioactivity: SR2211 is a potent, selective synthetic RORγ modulator and Bioactivity: SRT3109 is an antagonist of CXCR2, with a pIC50 of 8.2, and functions as an inverse agonist, with a K of 105 nM and an IC i used in the research of chemokine mediated diseases.

50 of ~320 nM.

Purity: 98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg, 50 mg Size: 10mM x 1mL in DMSO, 5 mg

SRT3190 SSR240612 Cat. No.: HY-13021 Cat. No.: HY-15039

Bioactivity: SRT3190 is an antagonist of CXCR2, used in the research of Bioactivity: SSR240612 is a potent, and orally active specific non-peptide

chemokine mediated diseases. bradykinin B1 receptor antagonist, with Kis of 0.48 nM and 0.73 nM for B1 receptors of human fibroblast MRC5 and HEK cells expressing human B1 receptors, 481 nM and 358 nM for B2 receptors of guinea pig ileum membranes and CHO cells… Purity: 99.61% Purity: 99.19% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

ST 2825 Stigmasterol Cat. No.: HY-50937 (Stigmasterin) Cat. No.: HY-N0131

Bioactivity: ST 2825 is a MyD88 dimerization inhibitor. Bioactivity: Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases.

Purity: 99.51% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Ethanol, 1 mg, 5 mg, 10 mg 100 mg

SU1498 Succinobucol (AG 1498; Tyrphostin SU 1498) Cat. No.: HY-19326 (AGI-1067; Probucol monosuccinate) Cat. No.: HY-14937

Bioactivity: SU1498 is a selective inhibitor of the VEGFR2; inhibits Flk-1 Bioactivity: Succinobucol is a phenolic antioxidant with anti-inflammatory

with an IC50 of value of 700 nM. and antiplatelet effects.

Purity: 99.46% Purity: 99.74% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

106 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Sucralfate Sulfasalazine (Sucrose octasulfate–aluminum complex) Cat. No.: HY-B0644 (NSC 667219) Cat. No.: HY-14655

Bioactivity: Sucralfate is a cytoprotective agent which has been employed Bioactivity: Sulfasalazine is a drug for the treatment of rheumatoid for prevention and treatment of several gastrointestinal arthritis and ulcerative colitis. Sulfasalazine is reported to diseases. suppress NF-κB activity.

Purity: Purity: 99.42% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 1 g, 5 g

Sulfogaiacol Cat. No.: HY-B2115 Cat. No.: HY-B0008

Bioactivity: Sulfogaiacol is a antitussive agent. Sulfogaiacol is used for Bioactivity: Sulindac is a non-steroidal antiinflammatory agent, acts as a acute respiratory tract infections, cough and other COX-2 inhibitor, and inhibits overexpression of COX-2. conditions.

Purity: 99.88% Purity: 99.46% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g 100 mg, 500 mg

SUN 1334H Suplatast Tosilate Cat. No.: HY-U00084 (IPD 1151T) Cat. No.: HY-17002

Bioactivity: SUN 1334H is a potent, orally active, highly selective H1 Bioactivity: Suplatast tosilate(IPD 1151T) is a Th2 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect receptor antagonist, with Ki of 9.7 nM. on IFN-γ production.

Purity: 95.0% Purity: 98.09% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 100 mg, 500 mg

Suprofen Cat. No.: HY-B0270 Cat. No.: HY-B1079

Bioactivity: is a non-steroidal anti-inflammatory drug (NSAID). Bioactivity: Suxibuzone is a drug used for joint and muscular pain, is a prodrug of the non steroidal anti inflammatory drug Phenylbutazone.

Purity: 99.44% Purity: 99.53% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 10 mg

Tacrolimus TAK-715 (Fujimycin; FR900506; FK506) Cat. No.: HY-13756 Cat. No.: HY-10456

Bioactivity: is a macrocyclic lactone with potent Bioactivity: TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, immunosuppressive properties. Tacrolimus binds to FK506 28-fold more selective for p38α over p38β, no inhibition to binding protein (FKBP) to form a complex and inhibits p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1. IC50 value: 7.1 nM calcineurin phosphatase. [1] Target: p38α MAPK in vitro: TAK 715 inhibits LPS-stimulated release of TNF-alpha from THP-1 with IC50 of 48… Purity: 98.46% Purity: 99.93% Clinical Data: Launched Clinical Data: Phase 2 Size: 50 mg, 100 mg, 200 mg, 500 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg

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TAK-779 Talabostat (Takeda 779) Cat. No.: HY-13406 (PT100) Cat. No.: HY-13233

Bioactivity: TAK-779 is a potent and selective nonpeptide antagonist of Bioactivity: Talabostat (PT100, Val-boroPro) is a potent, nonselective and

CCR5 and CXCR3, with a Ki of 1.1 nM for CCR5, and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. effectively and selectively inhibits R5 HIV-1, with EC50 …

Purity: 99.73% Purity: >98% Clinical Data: No Development Reported Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 50 mg 5 mg, 10 mg

Talabostat mesylate Talarozole (Val-boroPro; PT100) Cat. No.: HY-13233A (R115866) Cat. No.: HY-14531

Bioactivity: Talabostat mesylate is a potent, nonselective and orally Bioactivity: Talarozole is a potent inhibitor of both CYP26A1 and available dipeptidyl peptidase IV (DPP-IV) inhibitor with a K i CYP26B1, with IC50s of 5.4 and 0.46 nM, respectively. of 0.18 nM.

Purity: 98.0% Purity: 99.54% Clinical Data: Phase 3 Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 2 mg, 5 mg, 10 mg, 50 mg, 100 mg

Tangeretin Tannic acid (Tangeritin; NSC53909; NSC618905; Ponkanetin) Cat. No.: HY-N0133 Cat. No.: HY-B2136

Bioactivity: Tangeretin, a flavonoid from citrus fruit peels, has been Bioactivity: Tannic acid is a novel hERG channel blocker with IC50 of 3.4 proven to play an important role in anti-inflammatory μM. responses and neuroprotective effects in several disease models, and was also selected as a Notch-1 inhibitor.

Purity: 98.98% Purity: 81.68% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 1 g, 5 g

Tapinarof Taprenepag isopropyl (WBI 1001; ; GSK2894512) Cat. No.: HY-109044 (PF-04217329) Cat. No.: HY-19998

Bioactivity: Tapinarof is a natural aryl hydrocarbon receptor ( AhR) Bioactivity: Taprenepag isopropyl is a highly selective EP2 receptor agonist with an EC of 13 nM. 50 agonist.

Purity: 99.74% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Tarenflurbil Taurochenodeoxycholic acid ((R)-Flurbiprofen; MPC7869) Cat. No.: HY-10291 (12-Deoxycholyltaurine) Cat. No.: HY-N2027

Bioactivity: (R)-Flurbiprofen is the R-enantiomer of the racemate NSAID Bioactivity: Taurochenodeoxycholic acid is one of the main bioactive Flurbiprofen, (R)-Flurbiprofen inhibits the binding of [ substances of animals' . 3 H]9-cis-RA to RXRα LBD with IC50 of 75 μM.

Purity: 99.23% Purity: 99.80% Clinical Data: Phase 2 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 50 mg

108 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Taurocholic acid Taurocholic Acid sodium hydrate (N-Choloyltaurine; NSC 25505) Cat. No.: HY-B1788 (Sodium taurocholate hydrate) Cat. No.: HY-B1131

Bioactivity: Taurocholic acid is a bile acid involved in the emulsification Bioactivity: Taurocholic Acid sodium hydrate is a bile acid involved in the of fats. emulsification of fats.

Purity: >98% Purity: 95.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: Size: 10mM x 1mL in Water, 250 mg

Tavilermide Tazanolast (MIM-D3) Cat. No.: HY-17622 (TO 188; Tazalest; Tazanol) Cat. No.: HY-101810

Bioactivity: Tavilermide is a selective, partial agonist of TrkA, or a Bioactivity: Tazanolast is a selective mast-cell-stabilizing drug, on nerve growth factor (NGF) mimetic. ozone-induced airway hyperresponsiveness in guinea pigs.

Purity: 98.0% Purity: 99.50% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 50 mg, 100 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

Tazarotene TBK1/IKKε-IN-2 Cat. No.: HY-15388 Cat. No.: HY-12453

Bioactivity: is a selective retinoic acid receptor ( RAR) Bioactivity: TBK1/IKKε-IN-2 is a dual TBK1 and IKKε inhibitor. agonist for the treatment of plaque psoriasis and acne vulgaris.

Purity: 98.68% Purity: 98.50% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

TD-198946 TD139 Cat. No.: HY-15642 Cat. No.: HY-19940

Bioactivity: TD-198946, a thienoindazole derivative, is a potent Bioactivity: TD139 is an inhaled galectin-3 inhibitor with a Kd of 14 nM. chondrogenic agent.

Purity: 96.01% Purity: 99.39% Clinical Data: No Development Reported Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 50 mg, 100 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

Tectorigenin Temarotene Cat. No.: HY-N0792 (Ro 15-0778) Cat. No.: HY-U00011

Bioactivity: Tectorigenin is a plant isoflavonoid originally isolated from Bioactivity: Temarotene is an orally administered, particular arotinoid. the dried flower of Pueraria thomsonii Benth.

Purity: 99.98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 50 mg

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Tenosal Cat. No.: HY-12384 Cat. No.: HY-B0440

Bioactivity: Tenosal is a new compound obtained by esterifying salicylic Bioactivity: Tenoxicam, an antiinflammatory agent with analgesic and acid with 2-thiophene-carboxylic acid and displays antipyretic properties. anti-inflammatory, analgesic and antipyretic properties.

Purity: >98% Purity: 99.83% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 1 g, 5 g

Terbutaline sulfate ( hemisulfate) Cat. No.: HY-B0802 ((±)-Terfenadine; MDL-991) Cat. No.: HY-B1193

Bioactivity: Terbutaline sulfate is a β2-adrenergic receptor agonist; a Bioactivity: Terfenadine is a potent open-channel blocker of hERG with a fast-acting bronchodilator and a tocolytic to delay premature mean IC50 of 204 nM. labor.

Purity: 98.0% Purity: 98.26% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 1 g, 5 g 100 mg

Teriflunomide Terpin hydrate (A 77-1726) Cat. No.: HY-15405 (Terpin monohydrate; cis-Terpin hydrate) Cat. No.: HY-B1063

Bioactivity: Teriflunomide is the active metabolite of leflunomide, an Bioactivity: Terpin hydrate is an expectorant, commonly used to loosen approved therapy for rheumatoid arthritis. It inhibits mucus in patients presenting with acute or chronic bronchitis, synthesis and therefore potently decreases T cell and related conditions. and B cell proliferation.

Purity: 99.07% Purity: 95.0% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in Water, 10 mg, 50 mg, 100 mg, 500 mg 1 g

Tetrahydrobiopterin Tetrahydrocoptisine (Sapropterin) Cat. No.: HY-107383 ((RS)-Stylopine; (±)-Stylopin) Cat. No.: HY-N0924

Bioactivity: Tetrahydrobiopterin is a cofactor of the aromatic amino Bioactivity: Tetrahydrocoptisine is an alkaloid compound originally acid hydroxylases enzymes and also acts as an essential isolated from Corydalis tubers that exhibits anti-inflammatory cofactor for all nitric oxide synthase (NOS) isoforms. and anti-parasitic activities.

Purity: 98.63% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg 5 mg, 10 mg, 50 mg

Tetrahydrocurcumin (Fanchinine; Hanfangchin A; NSC 77037; (HZIV 81-2) Cat. No.: HY-N0893 S,S-(+)-Tetrandrine; Sinomenine A; TTD; Tetrandrin; …) Cat. No.: HY-13764

Bioactivity: Tetrahydrocurcumin is a Curcuminoid found in turmeric ( Bioactivity: Tetrandrine is a bis-benzyl-isoquinoline alkaloid, which Curcuma longa) that is produced by the reduction of inhibits voltage-gated Ca2+ current (ICa) and Ca Curcumin. Tetrahydrocurcumin inhibit CYP2C9 and CYP3A4. 2+-activated K+ current.

Purity: 95.0% Purity: 99.90% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 100 mg, 250 mg 5 mg, 10 mg

110 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

TG 100572 Hydrochloride THIARABINE Cat. No.: HY-10185 Cat. No.: HY-16496

Bioactivity: TG 100572 Hydrochloride is a multi-targeted kinase inhibitor Bioactivity: THIARABINE shows potent anti-tumor activity and inhibition of which inhibits receptor tyrosine kinases and Src kinases; has DNA synthesis.

IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively. Purity: 98.44% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 1 mg, 5 mg, 10 mg, 50 mg

Thiazinamium chloride Thiazolidinone-Derivatives-1 (Multergan chloride) Cat. No.: HY-U00267 Cat. No.: HY-100284

Bioactivity: Thiazinamium chloride possesses potent anticholinergic and Bioactivity: Thiazolidinone-Derivatives-1 is an antiulcer agent which inhibits the secretion of gastric acid. antiallergic activity and inhibits TxB2 synthesis with IC50 value of 0.2 µM.

Purity: 97.44% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg

Thymus factor X Tibenelast sodium (TFX-Jelfa) Cat. No.: HY-P0001 (LY 186655) Cat. No.: HY-101705

Bioactivity: Thymus factor X is a biologically active polypeptide which can Bioactivity: Tibenelast sodium is a phosphodiesterase inhibitor. be used as a natural stimulator of lymphocyte function.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

Timegadine (SR1368) Cat. No.: HY-100125 Cat. No.: HY-U00111

Bioactivity: Timegadine, a new antiinflammatory agent, is found to be a Bioactivity: Timobesone is a topical corticosteroid but never marketed. potent, competitive inhibitor of prostaglandin synthetase which also inhibits cyclo-oxygenase ( COX) and lipo-oxygenase.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

Timosaponin BII Tinoridine hydrochloride (Prototimosaponin A III) Cat. No.: HY-N0812 (Y-3642 hydrochloride) Cat. No.: HY-111354

Bioactivity: Timosaponin BII is an antioxidant and an anti-inflammatory Bioactivity: Tinoridine hydrochloride is a nonsteroidal anti-inflammatory agent. drug and also has potent radical scavenger and antiperoxidative activity.

Purity: 98.52% Purity: 98.07% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 5 mg, 10 mg, 50 mg, 100 mg

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Tiopinac TLK117 (RS 40974) Cat. No.: HY-U00063 (TER117) Cat. No.: HY-13634B

Bioactivity: Tiopinac is a highly potent anti-inflammatory, analgesic and Bioactivity: TLK117, the active metabolite of TLK199, selective inhibits

anti-pyretic agent. Glutathione S-transferase P1–1 (GSTP1-1) with a Ki of 0.4 μM for GSTP. TLK117 also competitively inhibits glyoxalase I with a

Ki of 0.56 μM. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 5 mg, 10 mg

TLR7-agonist-1 TLR7/8 agonist 1 dihydrochloride Cat. No.: HY-103039 Cat. No.: HY-103698A

Bioactivity: TLR7-agonist-1 is a potent and selective Toll-like Receptor 7 Bioactivity: TLR7/8 agonist 1 dihydrochloride is a toll-like receptor ( ( TLR7) agonist with a LEC of 0.4 μM. TLR7)/ TLR8 dual-agonistic imidazoquinoline.

Purity: 98.82% Purity: 98.02% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

TNF-α-IN-1 Tofacitinib Cat. No.: HY-112275 (Tasocitinib; CP-690550) Cat. No.: HY-40354

Bioactivity: TNF-α-IN-1 is a TNF-α inhibitor extracted from patent Bioactivity: Tofacitinib is a JAK1/2/3 inhibitor with IC50s of 1, 20, and US20030096841A1, compound example I-7. 112 nM, respectively.

Purity: >98% Purity: 99.96% Clinical Data: No Development Reported Clinical Data: Launched Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg

Tofacitinib citrate TOK-8801 (Tasocitinib citrate; CP-690550 citrate) Cat. No.: HY-40354A Cat. No.: HY-100162

Bioactivity: Tofacitinib citrate is a JAK1/2/3 inhibitor with IC50s of 1, Bioactivity: TOK-8801 is a synthesized dihydroimidazothiazole carboxamide 20, and 112 nM, respectively. and is under development as an immunomodulator.

Purity: 99.92% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 10 mg, 50 mg, 100 mg, 200 mg, 500 mg

Tolfenamic Acid Toll-like receptor modulator Cat. No.: HY-B0335 Cat. No.: HY-10018

Bioactivity: is a non-steroidal anti-inflammatory and Bioactivity: A Toll-like receptor modulator.

anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.

Purity: 99.93% Purity: 99.40% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 g, 10 g 5 mg, 10 mg, 50 mg

112 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Tolmetin sodium dihydrate Tomatidine Cat. No.: HY-B1489 Cat. No.: HY-N2149

Bioactivity: sodium dihydrate is a non-steroidal antiinflammatory Bioactivity: Tomatidine acts as an anti-inflammatory agent by blocking agent, and acts as a non-selective COX inhibitor. NF-κB and JNK signaling.

Purity: 99.77% Purity: 98.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 25 mg, 50 mg, 100 mg 100 mg

Tosufloxacin tosylate hydrate Toxicarol isoflavone (A-61827 tosylate hydrate) Cat. No.: HY-B1802A Cat. No.: HY-N1135

Bioactivity: Tosufloxacin (tosylate hydrate) is a fluoroquinolone Bioactivity: Toxicarol isoflavone is an isoflavone extracted from antibacterial agent. Millettia brandisiana.

Purity: 98.88% Purity: 99.13% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg 200 mg, 1 g, 5 g, 10 g

TPCA-1 TPI-1 Cat. No.: HY-10074 Cat. No.: HY-100463

Bioactivity: TPCA-1 is a potent and selective inhibitor of IKK-2 with IC50 Bioactivity: TPI-1 is a SHP-1 inhibitor; inhibits recombinant SHP-1 with an IC of 40 nM. of 17.9 nM. 50

Purity: 99.54% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

TPPU TR-14035 Cat. No.: HY-101294 Cat. No.: HY-15770

Bioactivity: TTPU is a soluble epoxide hydrolase ( sEH) inhibitor with Bioactivity: TR-14035 is a a dual alpha4beta7(IC50=7 nM)/alpha4beta1 (IC50=87 nM) integrin antagonist . IC50 values of 37 and 3.7 nM for monkey and human sEH, respectively.

Purity: 98.07% Purity: 95.78% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

Tranilast Tranilast Sodium (MK 341; SB 252218) Cat. No.: HY-B0195 (Sodium Tranilast; MK 341 Sodium; SB 252218 Sodium) Cat. No.: HY-B0195A

Bioactivity: Tranilast is an antiallergic agent. Target: Angiotensin Bioactivity: Tranilast is an antiallergic agent. Target: Angiotensin Receptor Tranilast has been approved in Japan and South Korea, Receptor Tranilast has been approved in Japan and South Korea, since 1982, for the treatment of bronchial asthma, with since 1982, for the treatment of bronchial asthma, with indications for keloids and hypertrophic scar added in 1993. indications for keloids and hypertrophic scar added in 1993. Tranilast is also used to treat asthma, autoimmune diseases,… Tranilast is also used to treat asthma, autoimmune diseases,… Purity: 99.60% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg 10 mg, 50 mg

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Tranilast trans- trans-Trimethoxyresveratrol (trans-trismethoxy Resveratrol; (trans-Tranilast) Cat. No.: HY-18706 E-Resveratrol Trimethyl Ether; Tri-O-methylresveratrol) Cat. No.: HY-N1408

Bioactivity: Trans-Tranilast is an antiallergic drug, used to treat Bioactivity: Trans-Trimethoxyresveratrol is a derivative of Resveratrol bronchial asthma, allergic rhinitis and atopic dermatitis. (RSV),and it may be a more potent anti-inflammatory, antiangiogenic and vascular-disrupting agent when compared with resveratrol.

Purity: 99.66% Purity: 99.72% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg 50 mg

TRAP-6 (PAR-1 agonist peptide; Activator Trehalose 6-behenate Peptide 6) Cat. No.: HY-P0078 Cat. No.: HY-101871

Bioactivity: TRAP-6 is a protease-activated receptor 1 (PAR1) agonist. Bioactivity: Trehalose 6-behenate is a Th1/Th17 skewing vaccine adjuvant. Sequence: Ser-Phe-Leu-Leu-Arg-Asn.

Purity: 99.82% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 5 mg, 10 mg, 25 mg

Treprostinil sodium (LRX-15) Cat. No.: HY-100441 (UT-15) Cat. No.: HY-16504

Bioactivity: Treprostinil sodium is a potent DP1 and EP2 agonist with Bioactivity: Treprostinil sodium is a potent DP1 and EP2 agonist with

EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively. EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.

Purity: 98.83% Purity: 98.49% Clinical Data: Launched Clinical Data: Launched Size: 2 mg, 5 mg, 10 mg, 25 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg

Triamcinolone acetonide Cat. No.: HY-B0328 Cat. No.: HY-B0636

Bioactivity: Triamcinolone is a long-acting synthetic corticosteroid. Bioactivity: is a more potent type of triamcinolone, being about 8 times as effective as prednisone.

Purity: 99.15% Purity: 99.08% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 500 mg 1 g, 5 g

Triamcinolone Benetonide Triamcinolone hexacetonide Cat. No.: HY-U00043 Cat. No.: HY-U00103

Bioactivity: Triamcinolone benetonide is a synthetic glucocorticoid Bioactivity: Triamcinolone hexacetonide is a commonly used long-acting corticosteroid with anti-inflammatory activity. in treatment of subacute and chronic inflammatory joint diseases.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 5 mg

114 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Trifarotene (CD5789) Cat. No.: HY-100256 Cat. No.: HY-B0531

Bioactivity: is a retinoic acid receptor ( RAR) agonist with Bioactivity: Triflusal irreversibly inhibits the production of app thromboxane-B2 in platelets by acetylating cycloxygenase-1. Kd of 2, 15 and 500 nM for RARγ, RARβ and RARα, Target: COX Triflusal at 10 mM, 100 mM and 1 M decreases LDH respectively. efflux in rat brain slices after anoxia/reoxygenation by 24%, 35% and 49% respectively. Triflusal also reduces inducible NO… Purity: >98% Purity: 99.66% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg

Trimethoprim Cat. No.: HY-B0510 (Trisoralen; Trioxysalen; Trimethylpsoralen; TMP) Cat. No.: HY-B1157

Bioactivity: Trimethoprim is a bacteriostatic antibiotic used mainly in the Bioactivity: Trioxsalen is a furanocoumarin and a psoralen derivative, in prophylaxis and treatment of urinary tract infections. conjunction with UV-A for phototherapy treatment of vitiligo and . After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death.

Purity: 99.98% Purity: 98.91% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 g, 10 g 100 mg, 500 mg

Tripelennamine hydrochloride Tritoqualine (Pyribenzamine hydrochloride) Cat. No.: HY-17428 (Inhibostamin; Hypostamine) Cat. No.: HY-U00065

Bioactivity: Hcl, a H1-receptor antagonist, is a Bioactivity: Tritoqualine is used as a histidine decarboxylase inhibitor. psychoactive drug and member of the pyridine andethylenediamine classes that is used as an antipruritic and first-generation antihistamine.

Purity: 99.87% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 100 mg, 200 mg, 500 mg, 1 g, 5 g

Troxerutin Troxipide (Trihydroxyethylrutin) Cat. No.: HY-N0139 Cat. No.: HY-B0758

Bioactivity: Troxerutin, also known as vitamin P4, is a Bioactivity: Troxipide is a novel gastro protective agent with antiulcer, tri-hydroxyethylated derivative of natural bioflavonoid rutins anti-inflammatory and mucus secreting properties. which can inhibit the production of reactive oxygen species ( ROS) and depress ER stress-mediated NOD activation.

Purity: 98.05% Purity: 99.39% Clinical Data: Phase 4 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg, 5 g 100 mg, 500 mg

TTP 22 Tuftsin Cat. No.: HY-15479 Cat. No.: HY-P0240

Bioactivity: TTP 22 is a potent CK2 inhibitor, with an IC50 of 100 nM and Bioactivity: Tuftsin is a tetrapeptide. Tuftsin is a macrophage/microglial activator. Sequence: Thr-Lys-Pro-Arg. a Ki of 40 nM.

Purity: 97.01% Purity: 98.40% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 5 mg, 10 mg, 25 mg 10 mg, 50 mg

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Tuftsin diacetate hydrochloride Cat. No.: HY-P0240A Cat. No.: HY-W011733

Bioactivity: Tuftsin diacetate, a tetrapeptide, is a Bioactivity: Tulobuterol hydrochloride is a β2-adrenoceptor agonist. macrophage/microglial activator. Sequence: Thr-Lys-Pro-Arg.

Purity: >98% Purity: 99.82% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 50 mg, 100 mg, 500 mg

Tunicamycin TY-51469 Cat. No.: HY-A0098 Cat. No.: HY-12370

Bioactivity: Tunicamycin is a N-acetylglucosamine containing antibiotic Bioactivity: TY-51469 is a chymase inhibitor with IC50s for simian and from Streptomyces lysosuperijkus which inhibits protein human chymases of 0.4 and 7.0 nM, respectively. glycosylation.

Purity: 99.69% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 2 mg, 5 mg Size: 250 mg, 500 mg

TYK2-IN-2 Tyk2-IN-3 Cat. No.: HY-101762 Cat. No.: HY-18709

Bioactivity: TYK2-IN-2 is an inhibitor of TYK2, used for treatment of Bioactivity: Tyk2-IN-3 is a Tyk2 pseudokinase inhibitor, with an IC50 of inflammatory and autoimmune diseases. 485 nM.

Purity: 99.41% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 250 mg, 500 mg 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

Tyk2-IN-4 Tyrphostin A1 Cat. No.: HY-117287 (Tyrphostin 1; AG9) Cat. No.: HY-16668

Bioactivity: Tyk2-IN-4 is a selective, potent, allosteric inhibitor of Bioactivity: Tyrphostin A1(AG9) inhibits CD40L-stimulated IL-12 production tyrosine kinase 2 ( Tyk2). in macrophage cultures and antigen-induced generation of Th1 cells. IC50 value: Target: IL-12 production inhibitor Addition of increasing concentration of A1 resulted in a dose dependent decrease of IL-12 p40, with maximal inhibition (62.5%)… Purity: >98% Purity: 99.25% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 10 mg, 100 mg

U-73122 U66858 Cat. No.: HY-13419 (Bunaprolast) Cat. No.: HY-U00170

Bioactivity: U-73122 is an inhibitor of (PLC), phospholipase Bioactivity: U66858 is a potent inhibitor of LTB4 production in human A2, and 5-LO (5-lipoxygenase). whole blood. U66858 also exhibits significant inhibition of

lipoxygenase and TXB2 release.

Purity: 98.17% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg, 50 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

116 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Ufenamate UK-371804 (Flufenamic acid butyl ester; Butyl flufenamate) Cat. No.: HY-100009 Cat. No.: HY-101214

Bioactivity: Ufenamate is a topical analgesic. Bioactivity: UK-371804 is a -type ( uPA)

inhibitor with a Ki of 10 nM.

Purity: 99.37% Purity: 98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

Umeclidinium bromide UP202-56 (GSK573719A) Cat. No.: HY-12100 Cat. No.: HY-U00226

Bioactivity: is a novel mAChR antagonist. The Bioactivity: UP202-56 is an adenosine analogue, which is an agonist. affinity ( Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM.

Purity: 99.72% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 50 mg, 100 mg

Upadacitinib (ABT-494) Cat. No.: HY-19569 Cat. No.: HY-B2130

Bioactivity: Upadacitinib (ABT-494) is a potent and selective Janus kinase Bioactivity: Uric acid is an endogenous antioxidant that scavenges reactive

( JAK) 1 inhibitor with an IC50 of 43 nM, being developed for oxygen species (ROS) including singlet oxygen, oxygen the treatment of several autoimmune disorders. radicals, and peroxynitrite.

Purity: 99.96% Purity: 99.0% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 1 g 500 mg, 1 g, 5 g, 10 g

Uridine triphosphate (UTP; 5'-triphosphate) Cat. No.: HY-107372 (SC 65872) Cat. No.: HY-15762

Bioactivity: (UTP;Uridine 5'-triphosphate) is a Bioactivity: Valdecoxib is a highly potent and selective inhibitor of

pyrimidine nucleoside triphosphate that participates in COX-2, with IC50s of 5 nM and 140 μM for COX-2 and COX-1, glycogen metabolism and synthesis of RNA during transcription. respeceively. Valdecoxib can be used in the research of arthritis and pain.

Purity: 98.0% Purity: 99.91% Clinical Data: Phase 3 Clinical Data: Launched Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 10 mg, 50 mg

Valrubicin (AD-32) Cat. No.: HY-13772 (LY315920) Cat. No.: HY-13402

Bioactivity: is a agent, inhibits TPA- and Bioactivity: LY315920 (Varespladib) is a potent and selective human

PDBu-induced PKC activation with IC50s of 0.85 and 1.25 μM, non-pancreatic secretory phospholipase A2 (sPLA) inhibitor respectively, and has antitumor and antiinflammatory activity. with IC50 of 7 nM. IC50 value: 7 nM Target: sPLA2 in vitro: LY315920 exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit,… Purity: 99.60% Purity: 98.03% Clinical Data: Launched Clinical Data: Phase 3 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

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Varespladib methyl Veledimex (A-002; LY333013; S-3013) Cat. No.: HY-17448 (INXN-1001; RG-115932) Cat. No.: HY-16785

Bioactivity: Varespladib methyl is a selective inhibitor of group II Bioactivity: Veledimex is an oral activator ligand for a proprietary gene secretory phospholipase A2 ( PLA2). therapy promoter system, and a moderate inhibitor of and substrate for CYP3A4/5.

Purity: >98% Purity: 99.09% Clinical Data: Phase 3 Clinical Data: Phase 2 Size: 1 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 25 mg, 50 mg

Veledimex racemate Verbascoside (RG-115932 racemate; INXN-1001 racemate) Cat. No.: HY-16785A (Acteoside; Kusaginin; TJC160) Cat. No.: HY-N0021

Bioactivity: Veledimex racemate is the racemate of veledimex. Veledimex is Bioactivity: Verbascoside is isolated from Lantana camara, acts as an

an orally available, small-molecule activator ligand for the ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and RheoSwitch Therapeutic System. has antitumor, anti-inflammatory and antineuropathic pain activity.

Purity: 98.0% Purity: 95.67% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 25 mg, 50 mg Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg

Vercirnon VGX-1027 (GSK-1605786; CCX282-B) Cat. No.: HY-15724 (GIT 27) Cat. No.: HY-15507

Bioactivity: Vercirnon is an orally bioavailable, selective, and potent Bioactivity: VGX-1027(GIT27) is an isoxazole compound that exhibits various

antagonist of CCR9, with an IC50 of 10 nM, used in the immunomodulatory properties; reduce the secretion of IL-1beta, research of inflammatory bowel diseases. TNF-alpha and IL-10 from purified murine macrophages.

Purity: 98.04% Purity: 99.92% Clinical Data: Phase 3 Clinical Data: Phase 1 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 10 mg, 50 mg

Vidofludimus (4sc-101; SC12267) Cat. No.: HY-14908 (GW642444X; GW642444) Cat. No.: HY-14300

Bioactivity: Vidofludimus(4SC-101; SC12267) is a novel immunosuppressive Bioactivity: Vilanterol is a long-acting β2-adrenoceptor (β 2-AR) drug that inhibits DHODH; inhibits IL-17 secretion in vitro agonist with 24 h activity. The pEC s for β -AR,β -AR independently of effects on lymphocyte proliferation. 50 2 1 and β 3-AR is 10.37±0.05, 6.98±0.03 and 7.36±0.03, respectively. Purity: 99.05% Purity: 95.06% Clinical Data: Phase 2 Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg, 100 mg

Vilanterol trifenatate Visomitin (GW642444M) Cat. No.: HY-14300A (SKQ1) Cat. No.: HY-100474

Bioactivity: Vilanterol trifenatate is a long-acting β2-adrenoceptor (β Bioactivity: Visomitin is a new antioxidant with the highest mitochondrion -AR) agonist with inherent 24-hour activity. The pEC s membrane penetrating ability and potent antioxidant 2 50 capability. for β 2-AR, β 1-AR and β 3-AR are 10.37, 6.98 and 7.36, respectively. Purity: 99.02% Purity: 98.0% Clinical Data: Launched Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

118 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Voclosporin VUF10460 (ISAtx-247) Cat. No.: HY-106638 Cat. No.: HY-101420

Bioactivity: Voclosporin is a calcineurin (CN) inhibitor. Bioactivity: VUF10460 is a non- histamine H4 receptor agonist;

binds to rat H4 receptor with a pKi of 7.46.

Purity: 99.20% Purity: 98.37% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

VX-702 VX-765 Cat. No.: HY-10401 (Belnacasan) Cat. No.: HY-13205

Bioactivity: VX-702 is a highly selective inhibitor of p38α MAPK(IC50=4 -20 Bioactivity: VX-765 is an oral prodrug of VRT-043198, a potent and

nM), 14-fold higher potency against the p38α versus p38β. IC50 selective caspase-1 inhibitor with a Ki of 0.8 nM. value: 4-20 nM [1] Target: p38α MAPK in vitro: Pre-incubation of platelets with VX-702 (1 μM) completely or partially inhibits p38 activation (IC50 4 to 20 nM) induced by platelet… Purity: 99.54% Purity: 99.99% Clinical Data: Phase 2 Clinical Data: Phase 2 Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg, 200 mg 5 mg, 10 mg, 50 mg, 100 mg

VX-809 Warangalone (Lumacaftor; VRT 826809) Cat. No.: HY-13262 (Scandenolone) Cat. No.: HY-N1074

Bioactivity: VX-809 is a CFTR modulator that corrects the folding and Bioactivity: Warangalone is an anti-malarial compound which can inhibit the trafficking of CFTR protein. growth of both strains of parasite 3D7 (chloroquine

sensitive) and K1 (chloroquine resistant) with IC50s of 4.8 μg/mL and 3.7 μg/mL, respectively. Warangalone can also inhibit cyclic AMP-dependent protein kinase catalytic subunit (… Purity: 99.12% Purity: 98.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg 5 mg, 10 mg, 50 mg, 100 mg

WAY-204688 WAY-600 (SIM-688) Cat. No.: HY-19498 Cat. No.: HY-15272

Bioactivity: WAY-204688 is an estrogen receptor ( ER-α) selective, Bioactivity: WAY-600 is a potent, ATP-competitive, and selective mTOR

orally active inhibitor of NF-κB transcriptional activity inhibitor with an IC50 of 9 nM for recombinant mTOR enzyme. with an IC 50 of 122±30 nM for NF-κB-luciferase (NF-κB-luc) WAY-600 blocks mTOR complex 1/2 ( mTORC1/ 2) assemble and in HAECT-1 cells. activation.

Purity: >98% Purity: 95.41% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg

WAY127093B racemate WHI-P97 Cat. No.: HY-101749 Cat. No.: HY-11067

Bioactivity: WAY127093B racemate is the racemate of WAY127093B. Bioactivity: WHI-P97 is a rationally designed potent inhibitor of JAK-3. WAY127093B IC50 value: Target: JAK3 Treatment of mast cells with WHI-P97 is a novel, orallyactive phosphodiesterase IV inhibitor in inhibited the translocation of 5-lipoxygenase (5-LO) from the guinea pigs and rats. nucleoplasm to the nuclear membrane and consequently 5-LO-dependent leukotriene (LT) synthesis after IgE… Purity: >98% Purity: 99.48% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg

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Wilforlide A Withaferin A (Regelide; Abruslactone A) Cat. No.: HY-N0476 Cat. No.: HY-N2065

Bioactivity: Wilforlide A is a natural product, separated from the Bioactivity: Withaferin A is a steroidal lactone isolated from Withania ethanolic extract of tripterygium wilfordii. somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities.

Purity: 99.60% Purity: 99.68% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg 1 mg, 5 mg

Wogonin WS3 Cat. No.: HY-N0400 Cat. No.: HY-12462

Bioactivity: is a naturally occurring mono-flavonoid, can inhibit Bioactivity: WS3 is a novel small molecule that promotes β cell the activity of CDK8 and Wnt, and exhibits proliferation with EC50 of 28 nM(induced R7T1 proliferation). anti-inflammatory and anti-tumor effects.

Purity: 99.83% Purity: 98.78% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 10 mg, 50 mg, 100 mg

WS6 Wy 49051 Cat. No.: HY-12461 Cat. No.: HY-101830

Bioactivity: WS6 is a novel small molecule that promotes β cell Bioactivity: Wy 49051 is a potent, orally active H1 receptor antagonist, proliferation in rodent and human primary islets with EC50 of with IC50 of 44 nM. 0.28 uM(R7T1 cell viability). EC50 value: 0.28 uM [1] Target: β cell proliferation agonist in vitro: WS6 induced up to 4% of rat β cells to proliferate, with an EC50 of 0.4 μM. In the… Purity: 98.02% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 50 mg

Wy-14643 (Pirinixic acid) Cat. No.: HY-16995 Cat. No.: HY-W017389

Bioactivity: Wy-14643 is a potent agonist of PPARα, with EC50s of 0.63 Bioactivity: Xanthine is a base found in most human body tissues and μM, 32 μM for murine PPARα and PPARγ, and 5.0 μM, 60 μM, 35 fluids and in other organisms. μM for human PPARα, PPARγ and PPARδ, respectively.

Purity: 99.69% Purity: 95.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg, 250 mg 1 g

Xanthotoxol Y-320 Cat. No.: HY-30152 Cat. No.: HY-15898

Bioactivity: Xanthotoxol is a biologically active linear furocoumarin, Bioactivity: Y-320 is a new phenylpyrazoleanilide immunomodulator; inhibits shows strong pharmacological activities as anti-inflammatory, IL-17 production by CD4 T cells stimulated with IL-15 with antioxidant, 5-HT antagonistic, and neuroprotective effects. IC50 values of 20 to 60 nM.

Purity: 99.15% Purity: 99.07% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg

120 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Yangonin YKL-05-099 Cat. No.: HY-N0919 Cat. No.: HY-101147

Bioactivity: Yangonin exhibits affinity for the human recombinant Bioactivity: YKL-05-099 is a salt-inducible kinase ( SIK) probe; inhibits cannabinoid CB1 receptor with an IC and a K of 1.79 ± 50 i SIK2 with an IC50 of 40 nM. 0.53 μM and 0.72±0.21 μM, respectively.

Purity: >98% Purity: 99.76% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg Size: 10mM x 1mL in DMSO, 1 mg, 5 mg, 10 mg, 50 mg, 100 mg

YM-264 YM-58483 Cat. No.: HY-101833 (BTP2) Cat. No.: HY-100831

Bioactivity: YM-264 is a selective, potent and orally active Bioactivity: YM-58483 is the first selective and potent inhibitor of CRAC platelet-activating factor (PAF) antagonist with a pKi value channels and subsequent Ca 2+ signals. of 8.85 for rabbit platelet membranes.

Purity: >98% Purity: 98.31% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 250 mg, 500 mg Size: 10mM x 1mL in DMSO, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

YM-90709 YM158 free base Cat. No.: HY-19969 (YM-57158) Cat. No.: HY-U00355

Bioactivity: YM-90709 is a novel antagonist which inhibits the binding of Bioactivity: YM158 free base is a potent and selective LTD4 and TXA2 interleukin-5 to interleukin-5 receptor. receptor antagonist with pA2 values of about 8.87 and 8.81, respectively.

Purity: 99.14% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 5 mg, 10 mg, 25 mg, 50 mg

Z-Ile-Glu-Pro-Phe-Ome Cat. No.: HY-16707 (ICI 204219) Cat. No.: HY-17492

Bioactivity: Z-Ile-Glu-Pro-Phe-Ome is a peptide inhibitor of human heart Bioactivity: Zafirlukast is a potent orally active leukotriene D4 ( chymase. LTD4) receptor antagonist.

Purity: 95.0% Purity: 99.10% Clinical Data: No Development Reported Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg 100 mg, 500 mg

Zaltoprofen Zardaverine (CN100) Cat. No.: HY-B0619 Cat. No.: HY-15485

Bioactivity: (CN100) is an inhibitor of COX for treatment of Bioactivity: Zardaverine is a newly developed dual-selective PDE3/4 arthritis. inhibitor with IC50 values of 0.5 uM and 0.8 uM respectively.

Purity: 99.09% Purity: 98.17% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 10 mg, 50 mg, 100 mg 5 mg, 10 mg, 50 mg

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Zaurategrast ZD8321 (CDP323) Cat. No.: HY-70073 Cat. No.: HY-U00256

Bioactivity: Zaurategrast is a potent and oral-effective α4-integrin Bioactivity: ZD8321 is a potent inhibitor of human Neutrophil elastase ( NE) with a K of 13±1.7 nM. inhibitor. i

Purity: 98.81% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg, 5 mg, 10 mg 5 mg, 10 mg, 25 mg

Zileuton sodium (A 64077; Abbott 64077) Cat. No.: HY-14164 Cat. No.: HY-14164A

Bioactivity: Zileuton is a potent and selective inhibitor of 5-lipoxygenase, Bioactivity: Zileuton sodium is a potent and selective inhibitor of exhibiting inflammatory activities. 5-lipoxygenase, exhibiting inflammatory activities.

Purity: 99.93% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10mM x 1mL in DMSO, Size: 10 mg, 50 mg, 100 mg 10 mg, 50 mg, 100 mg

ZK-261991 ZK-90055 hydrochloride Cat. No.: HY-15333 Cat. No.: HY-U00293

Bioactivity: ZK-261991 is an orally active VEGFR tyrosine kinase inhibitor Bioactivity: ZK-90055 hydrochloride is a β2 adrenergic receptor agonist.

with an IC50 of 5 nM for VEGFR2.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 1 mg, 5 mg, 10 mg, 20 mg

Zomepirac sodium salt [Des-Arg9]-Bradykinin (McN-2783-21-98) Cat. No.: HY-B0890 Cat. No.: HY-P0298

Bioactivity: sodium salt is a pyrrole- structurally Bioactivity: [Des-Arg9]-Bradykinin is a Bradykinin ( B1) receptor agonist related to tolmetin sodium; a prostaglandin synthetase that displays selectivity for B over B receptors. inhibitor. 1 2 Sequence: Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe.

Purity: 99.40% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 5 mg, 10 mg, 25 mg 100 mg, 500 mg

[Des-Arg9]-Bradykinin acetate α-2,3-sialyltransferase-IN-1 Cat. No.: HY-P0298A Cat. No.: HY-112535

Bioactivity: [Des-Arg9]-Bradykinin acetate is a Bradykinin B1 receptor Bioactivity: α-2,3-sialyltransferase-IN-1 is a noncompetitive α-2,3-sialyltransferase inhibitor with an IC of 6 μM. agonist that displays selectivity for B 1 over B 2 50 receptors.

Purity: 99.06% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg 5 mg, 10 mg, 50 mg

122 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

α-Lipoic Acid β-CGRP, human ((±)-α-Lipoic acid; DL-α-Lipoic acid; Thioctic acid) Cat. No.: HY-N0492 (Human β-CGRP; CGRP-II (Human)) Cat. No.: HY-P1548

Bioactivity: α-Lipoic Acid is an antioxidant, which is an essential Bioactivity: β-CGRP, human is one of , acts via the cofactor of mitochondrial enzyme complexes. α-Lipoic Acid complex of calcitonin-receptor-like receptor (CRLR) and

inhibits NF-κB-dependent HIV-1 LTR activation. receptor-activity-modifying protein (RAMP), with IC50s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells.

Purity: 98.03% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 500u g, 1 mg, 5 mg 500 mg

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