CSID-Abstracts.Pdf

Total Page:16

File Type:pdf, Size:1020Kb

CSID-Abstracts.Pdf The 5th Annual Meeting of Chinese Society of Investigative Dermatology contents Contents E-poster PO-001 Protective properties on oxidative damage of Isorhamnetin and Kaempferol extracted from Vernonia anthelmintica (L.) Willd seeds in human primary melanocytes and keratinocytes ---------------------------------------------------------------------------- HuWen,Wang Hongjuan,Zhang Kunjie,etc 1 PO-002 Effect of IL-17A on NF-κB signaling pathway in human epidermal keratinocytes --------------------------------------------------------------------------------- LiShuang,Hou Shaowei,Feng Jian,etc 2 PO-003 Metabolomics profiling reveals alterations of amino acid and carnitine are metabolic signatures in psoriasisChenChao,Hou Guixue,Zeng Chunwei,etc -------------------------------------------------------------------------- 3 PO-004 Lysophosphatidylcholine promotes the development of psoriasis through metabolic reprogramming ------------------------------------------------------------------------------------ Panpan Liu,Cong Peng,Xiang Chen 4 PO-005 Circular RNA circLOC101928570 suppress systemic lupus erythematosus progression via targeting the miR-150/c-myb axis ---------------------------------------------------- Xingwang Zhao,Longlong Zhang,Junkai Guo,etc 5 PO-006 A novel role of IL-17A in contributing to the impaired suppressive function of Tregs in psoriasis ----------------------------------------------------------------------------------- Yanghe Liu,Luting Yang,Gang Wang 6 PO-007 Expression of co-inhibitory receptors in psoriasis and correlation with clinical improvement of anti-TNF- α therapy -------------------------------------------------------------------------------- Yingyuan Yu,Zeyu Chen,Ying Li,etc 7 PO-008 The P2Y6 targeting PIK3R2 inhibits keratinocyte proliferation in psoriasis by regulating of PETN/PI3K/AKT pathway ------------------------------------------------------------------------------------ peng xu,Yuling Shi 8 PO-009 The effect of TLR7/MyD88 signaling pathway inducing chemokine CXCL16 on the activation of neutrophils in pustular psoriasis ------------------------------------------------------------- Jiajing Lu,Ying Li,Ning Yu,etc 9 PO-010 Study on the correlation between circulating monocyte subsets and the pathogenesis of SLE -------------------------------------------------------------------------- Cuie Gao,Wenying Liu,Shuguang Chen,etc 10 PO-011 MucopolysaccharidePolysulfate as Treatment for adult blaschkitis with features of lichen planus pigmentosus ----------------------------------------------------------------------------- Zhaoshengnan,Qi ruiqun,Zhang shifa 11 PO-012 Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) ameliorate psoriasis in mice by inhibiting inflammatory responses mediated by IL-17A-producing γδ T cells --------------------------------------------------------------------------------ChenYoudong,Hu Yifan,Zhang Xilin,etc 12 PO-013 Non-classical activation of nitroso-dapsone-specific CD8+ T-cells through MHC Class II contributes to evidence of promiscuous drug-haptens in patients with DRESS ------------ ZhaoQing,Sun Lele,Sun Yonghu,etc 13 PO-014 Preliminary study on expression and clinical value of circRNAs in PBMC of Systemic Lupus Erythematous -------------------------------------------------------------------------------- LiWenyu,Fan Runge,Wei Yue,etc 14 PO-015 Epidural Nerve Block by Lidocaine for the Treatment of Psoriasis --------------------------------------------------------------------------------- Qianqian Yin,Qifang Li,Xiaojie Cai,etc 15 PO-016 TWEAK participates in the pathogenesis of pemphigus ------------------ SiJia Wang,Yumin Xia,Yale Liu 16 PO-017 Immune complexes containing Anti–Acidic Ribosomal Protein P0 elicits pro-inflammatory cytokine production by human M-CSF-oriented macrophages in Systemic Lupus Erythematosus ------------------------------------------------------------------------------ WenJingjing,Lan Jiajia,Zhang Yamin,etc 17 PO-018 In vivo inhibition of miRNA-21 alleviates the progression of murine lupus by regulating aberrant 1 The 5th Annual Meeting of Chinese Society of Investigative Dermatology contents differentiation of T follicular helper cells -------------------------------------------- Xiaofei Gao,Limin Liu,Xiaoli Min,etc 18 PO-019 Downregulation of UHRF1 enhance BCL6 expression and promote Tfh differentiation in SLE ---------------------------------------------------------------------------------- liulimin,hu longyuan,yang linxuan,etc 19 PO-020 Loss of 5-hydroxymethylcytosine in Primary cutaneous CD4+ small /medium sized pleomorphic T-cell lymphoproliferative disorder -------------------------------------------------------------------------- jiahui hu,Songmei Geng 23 PO-021 Prognosis and Predictive Significance of Adenylate kinase 4 in Mammary and Extramammary Paget’s disease ---------------------------------------------------------------------------------------------------------------- WangYangbin, 24 PO-022 ATP-citrate lyase epigenetically potentiates oxidative phosphorylation to promote melanoma growth and MAPK inhibition adaptive resistance ---------------------------- Weinan Guo,Jinyuan Ma,Sen Guo,Huina Wang,etc 24 PO-023 Effects on matrix metalloproteinases MMP2 and MMP9 in melanoma cells by the transfection with T-cadherin ----------------------------------------------------------------------- duanxinsuo,Zhang ShengWei,Lu HaiTao,etc 25 PO-024 PCDH9 target RAC1/ROS-NADPH-oxidase complex with the assist of Pyk2 interaction through Cyclin D1 trafficking -------------------------------------------------------------------------------------------------------------- ChenRong, 28 PO-025 Trichilemmal carcinoma of the scalp in a young female: a case report ---------------------------------------------------------------------------------- Qiuyu Jia,Xue Chen,Dandan Mao,etc 29 PO-026 Seryl tRNA synthetase cooperates with POT1 to regulate the length of telomere and cellular senescence in tumor cells ------------------------------------------------------------------------------------- LiYingXi,Hu LiZhi 29 PO-027 Targeting YAP1 through BET Bromodomain Inhibition as a Therapeutic Approach to Melanoma ----------------------------------------------------------------------------------------- Yao Li,Mingzhu Yin,Xiang Chen 31 PO-028 Exploration of genetic patterns in different endothelial cell lines associated with Kaposi sarcoma virus infection -------------------------------------------------------------------------------- Peng Wang,Wen Hu,Xiaojing Kang,etc 32 PO-029 Differential SATB1 expression reveals heterogeneity of cutaneous T cell lymphoma ------------------------------------------------------------------- Yumei Gao,Fengjie Liu,Jingru Sun,Yujie Wen,etc 33 PO-030 Predicting the risk of psoriatic arthritis in psoriasis patients: development and assessment of a new predictive nomogram ---------------------------------------------------------------- Panpan Liu,Yehong Kuang,Wu Zhu,etc 35 PO-031 Hippo-YAP signaling play a key role in IL-17A promoted psoriatic epidermis hyperplasia --------------------------------------------------------------------------------------------------- Zengyang Yu,Yuling Shi 36 PO-032 Comparative Study of dermoscopy and curettage in examination of scabies ------------------------------------------------------------------------------ ChenZhiRui,Wei Ling,Yin SongChao,etc 37 PO-033 Rapid improvement of Psoriasis Vulgaris in a patient with hypothyroidism after using Secukinumab - --------------------------------------------------------------------------------- Zhaoshengnan,Qi Ruiqun,Zhang shifa 37 PO-034 Factors Associated with Multibacillary Leprosy in Northwest China: A Retrospective Observational Study ----------------------------------------------------------------------------- LiGe,ZHANG Hong,ZHANG Qingping,etc 38 PO-035 Sensitive skin in China: An updated epidemiological approach ------------------------------------------------------------------- LiangYuan,Seité Sophie,Delvigne Véronique,etc 39 PO-036 Methylation of IFI44L gene for differential diagnosis of SLEwith tumor, hepatitis and myositislimin liu, -------------------------------------------------------------------------------------------------------- bo zhang,ming zhao 40 PO-037 Study of skin aging traits around eyes, neck, face and hands in Chinese women of different ages. -- --------------------------------------------------------------------------------Qianqian Wang,Liyuan Qiao,Rui Ye,etc 41 PO-038 Investigation on risk factors of postherpetic neuralgia and its relationship with viral load ------------------------------------------------------------------------------------------------------------------- YuJunFeng, 42 PO-039 Evaluation of the efficacy of 5-aminolevulinic acid photodynamic therapy on vulvar condyloma 2 The 5th Annual Meeting of Chinese Society of Investigative Dermatology contents acuminata in pregnancy and the effect on delivery -------------------------------------------- FengYingJun,Zeng Kang 43 PO-040 IL-17A antagonists on the Immunomodulatory of lymphocyte activation gene 3 (LAG-3) in moderate to severe plaque psoriasis --------------------------------------------------------------------- gongyu,Hu Yifan,Chen Zeyu,etc 43 PO-041 Risk of recurrence for adult-onset Still’s disease: A retrospective study of 56 patients. -------------------------------------------------------------------------------------- Sheng Li,Hong Fang,Jianjun Qiao 45 PO-042 Comparison of behavioral risk factors and cardiometabolic comorbidities of psoriatic arthritis
Recommended publications
  • Baicalein Inhibits Benzo [A] Pyrene-Induced Toxic Response by Downregulating Src Phosphorylation and by Upregulating NRF2-HMOX1 System
    antioxidants Article Baicalein Inhibits Benzo[a]pyrene-Induced Toxic Response by Downregulating Src Phosphorylation and by Upregulating NRF2-HMOX1 System Yuka Tanaka 1 , Takamichi Ito 1, Gaku Tsuji 1,2 and Masutaka Furue 1,2,3,* 1 Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan; [email protected] (Y.T.); [email protected] (T.I.); [email protected] (G.T.) 2 Research and Clinical Center for Yusho and Dioxin, Kyushu University Hospital, Fukuoka 812-8582, Japan 3 Division of Skin Surface Sensing, Department of Dermatology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan * Correspondence: [email protected]; Tel.: +81-92-642-5581; Fax: +81-92-642-5600 Received: 1 June 2020; Accepted: 8 June 2020; Published: 9 June 2020 Abstract: Benzo[a]pyrene (BaP), a major environmental pollutant, activates aryl hydrocarbon receptor (AHR), induces its cytoplasmic-to-nuclear translocation and upregulates the production of cytochrome P450 1A1 (CYP1A1), a xenobiotic metabolizing enzyme which metabolize BaP. The BaP-AHR-CYP1A1 axis generates reactive oxygen species (ROS) and induces proinflammatory cytokines. Although the anti-inflammatory phytochemical baicalein (BAI) is known to inhibit the BaP-AHR-mediated CYP1A1 expression, its subcellular signaling remains elusive. In this study, normal human epidermal keratinocytes and HaCaT keratinocytes were treated with BAI, BaP, or BAI + BaP, and assessed for the CYP1A1 expression, antioxidative pathways, ROS generation, and proinflammatory cytokine expressions. BAI and BAI-containing herbal medicine Wogon and Oren-gedoku-to could inhibit the BaP-induced CYP1A1 expression.
    [Show full text]
  • Inflammation/Immunology
    Inflammation/Immunology The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency. www.MedChemExpress.com 1 Inflammation/Immunology Inhibitors & Modulators (+)-Borneol (+)-DHMEQ ((1R,2R,6R)-Dehydroxymethylepoxyquinomicin; (d-Borneol) Cat. No.: HY-N1368A (1R,2R,6R)-DHMEQ) Cat. No.: HY-14645A Bioactivity: (+)-Borneol (d-Borneol) is a natural bicyclic monoterpene used Bioactivity: (+)-DHMEQ is an activator of antioxidant transcription factor for analgesia and anesthesia in traditional Chinese medicine; Nrf2. (+)-DHMEQ is the enantiomer of (-)-DHMEQ. (-)-DHMEQ enhances GABA receptor activity with an EC50 of 248 μM. inhibits NF-kB than its enantiomer (+)-DHMEQ. Purity: 98.0% Purity: 98.02% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 2 mg, 5 mg, 10 mg, 25 mg (-)-Epicatechin (-)-Ketoconazole ((-)-Epicatechol; Epicatechin; epi-Catechin) Cat. No.: HY-N0001 Cat. No.: HY-B0105B Bioactivity: (-)-Epicatechin inhibits cyclooxygenase-1 ( COX-1) with an Bioactivity: (-)-Ketoconazole is one of the enantiomer of Ketoconazole. Ketoconazole is a racemic mixture of two enantiomers, IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the levoketoconazole ((2S,4R)-(−)-ketoconazole) and p65 subunit of NF-κB.
    [Show full text]
  • Aryl Hydrocarbon Receptor in Atopic Dermatitis and Psoriasis
    International Journal of Molecular Sciences Review Aryl Hydrocarbon Receptor in Atopic Dermatitis and Psoriasis Masutaka Furue 1,2,3,* , Akiko Hashimoto-Hachiya 1,2 and Gaku Tsuji 1,2 1 Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan; [email protected] (A.H.-H.); [email protected] (G.T.) 2 Research and Clinical Center for Yusho and Dioxin, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan 3 Division of Skin Surface Sensing, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan * Correspondence: [email protected]; Tel.: +81-92-642-5581; Fax: +81-92-642-5600 Received: 15 October 2019; Accepted: 25 October 2019; Published: 31 October 2019 Abstract: The aryl hydrocarbon receptor (AHR)/AHR-nuclear translocator (ARNT) system is a sensitive sensor for small molecular, xenobiotic chemicals of exogenous and endogenous origin, including dioxins, phytochemicals, microbial bioproducts, and tryptophan photoproducts. AHR/ARNT are abundantly expressed in the skin. Once activated, the AHR/ARNT axis strengthens skin barrier functions and accelerates epidermal terminal differentiation by upregulating filaggrin expression. In addition, AHR activation induces oxidative stress. However, some AHR ligands simultaneously activate the nuclear factor-erythroid 2-related factor-2 (NRF2) transcription factor, which is a master switch of antioxidative enzymes that neutralizes oxidative stress. The immunoregulatory system governing T-helper 17/22 (Th17/22) and T regulatory cells (Treg) is also regulated by the AHR system. Notably, AHR agonists, such as tapinarof, are currently used as therapeutic agents in psoriasis and atopic dermatitis.
    [Show full text]
  • Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis
    International Journal of Molecular Sciences Review Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis Masutaka Furue 1,2,3 1 Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan; [email protected]; Tel.: +81-92-642-5581; Fax: +81-92-642-5600 2 Research and Clinical Center for Yusho and Dioxin, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan 3 Division of Skin Surface Sensing, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan Received: 7 July 2020; Accepted: 28 July 2020; Published: 29 July 2020 Abstract: Atopic dermatitis (AD) is an eczematous, pruritic skin disorder with extensive barrier dysfunction and elevated interleukin (IL)-4 and IL-13 signatures. The barrier dysfunction correlates with the downregulation of barrier-related molecules such as filaggrin (FLG), loricrin (LOR), and involucrin (IVL). IL-4 and IL-13 potently inhibit the expression of these molecules by activating signal transducer and activator of transcription (STAT)6 and STAT3. In addition to IL-4 and IL-13, IL-22 and IL-17A are probably involved in the barrier dysfunction by inhibiting the expression of these barrier-related molecules. In contrast, natural or medicinal ligands for aryl hydrocarbon receptor (AHR) are potent upregulators of FLG, LOR, and IVL expression. As IL-4, IL-13, IL-22, and IL-17A are all capable of inducing oxidative stress, antioxidative AHR agonists such as coal tar, glyteer, and tapinarof exert particular therapeutic efficacy for AD.
    [Show full text]
  • More Than Resveratrol: New Insights Into Stilbene-Based Compounds
    biomolecules Review More Than Resveratrol: New Insights into Stilbene-Based Compounds 1, 2, 3 3, Paulina Pecyna y, Joanna Wargula y , Marek Murias and Malgorzata Kucinska * 1 Department of Genetics and Pharmaceutical Microbiology, University of Medical Sciences, Swiecickiego 4 Street, 60-781 Poznan, Poland; [email protected] 2 Department of Organic Chemistry, University of Medical Sciences, Grunwaldzka 6 Street, 60-780 Poznan, Poland; [email protected] 3 Department of Toxicology, University of Medical Sciences, Dojazd 30 Street, 60-631 Poznan, Poland; [email protected] * Correspondence: [email protected] These authors contributed equally to this work. y Received: 29 June 2020; Accepted: 22 July 2020; Published: 27 July 2020 Abstract: The concept of a scaffold concerns many aspects at different steps on the drug development path. In medicinal chemistry, the choice of relevant “drug-likeness” scaffold is a starting point for the design of the structure dedicated to specific molecular targets. For many years, the chemical uniqueness of the stilbene structure has inspired scientists from different fields such as chemistry, biology, pharmacy, and medicine. In this review, we present the outstanding potential of the stilbene-based derivatives. Naturally occurring stilbenes, together with powerful synthetic chemistry possibilities, may offer an excellent approach for discovering new structures and identifying their therapeutic targets. With the development of scientific tools, sophisticated equipment, and a better understanding of the disease pathogenesis at the molecular level, the stilbene scaffold has moved innovation in science. This paper mainly focuses on the stilbene-based compounds beyond resveratrol, which are particularly attractive due to their biological activity.
    [Show full text]
  • Immunology/Inflammation
    Inhibitors, Agonists, Screening Libraries www.MedChemExpress.com Immunology/Inflammation The immune system has evolved to survey and respond appropriately to the universe of foreign pathogens, deploying an intricate repertoire of mechanisms that keep responses to host tissues in check. The immune system is typically divided into two categories--innate and adaptive. Innate immunity refers to nonspecific defense mechanisms that come into play immediately or within hours of an antigen's appearance in the body. Adaptive immunity refers to antigen-specific immune response. The antigen first must be processed and recognized, and then the adaptive immune system creates an army of immune cells specifically designed to attack that antigen. For the adaptive immune system, specificity and sensitivity are provided by a large repertoire of antigen T-cell receptors (TCRs) constructed in their extracellular domain to recognize antigenic peptide fragments restricted and presented by histocompatibility complex molecules, and coupled through intracellular domains to signal transduction modules that serve to transmit environmental cues inside the cell. Inflammation is triggered when innate immune cells detect infection or tissue injury. Pattern recognition receptors (PRRs) respond to pathogen-associated molecular patterns (PAMPs) or host-derived damage-associated molecular patterns (DAMPs) by triggering activation of NF-κB, AP1, CREB, c/EBP, and IRF transcription factors. Induction of genes encoding enzymes, chemokines, cytokines, adhesion molecules, and regulators of the extracellular matrix promotes the recruitment and activation of leukocytes. Besides resolving infection and injury, chronic inflammation is a risk factor for cancer. Immunity has a major impact on inflammatory diseases and cancer, and biologics targeting immune cells and their factors.
    [Show full text]
  • Immunology/Inflammation
    Inhibitors, Agonists, Screening Libraries www.MedChemExpress.com Immunology/Inflammation The immune system has evolved to survey and respond appropriately to the universe of foreign pathogens, deploying an intricate repertoire of mechanisms that keep responses to host tissues in check. The immune system is typically divided into two categories--innate and adaptive. Innate immunity refers to nonspecific defense mechanisms that come into play immediately or within hours of an antigen's appearance in the body. Adaptive immunity refers to antigen-specific immune response. The antigen first must be processed and recognized, and then the adaptive immune system creates an army of immune cells specifically designed to attack that antigen. For the adaptive immune system, specificity and sensitivity are provided by a large repertoire of antigen T-cell receptors (TCRs) constructed in their extracellular domain to recognize antigenic peptide fragments restricted and presented by histocompatibility complex molecules, and coupled through intracellular domains to signal transduction modules that serve to transmit environmental cues inside the cell. Inflammation is triggered when innate immune cells detect infection or tissue injury. Pattern recognition receptors (PRRs) respond to pathogen-associated molecular patterns (PAMPs) or host-derived damage-associated molecular patterns (DAMPs) by triggering activation of NF-κB, AP1, CREB, c/EBP, and IRF transcription factors. Induction of genes encoding enzymes, chemokines, cytokines, adhesion molecules, and regulators of the extracellular matrix promotes the recruitment and activation of leukocytes. Besides resolving infection and injury, chronic inflammation is a risk factor for cancer. Immunity has a major impact on inflammatory diseases and cancer, and biologics targeting immune cells and their factors.
    [Show full text]
  • Bacterial Pathogens: Threat Or Treat (A Review on Bioactive Natural Products from Cite This: Nat
    Natural Product Reports View Article Online REVIEW View Journal | View Issue Bacterial pathogens: threat or treat (a review on bioactive natural products from Cite this: Nat. Prod. Rep.,2021,38,782 bacterial pathogens)† Fleurdeliz Maglangit, *ab Yi Yu *c and Hai Deng *b Covering: up to the second quarter of 2020 Threat or treat? While pathogenic bacteria pose significant threats, they also represent a huge reservoir of potential pharmaceuticals to treat various diseases. The alarming antimicrobial resistance crisis and the dwindling clinical pipeline urgently call for the discovery and development of new antibiotics. Pathogenic bacteria have an enormous potential for natural products drug discovery, yet they remained untapped and understudied. Herein, we review the specialised metabolites isolated from entomopathogenic, Creative Commons Attribution 3.0 Unported Licence. phytopathogenic, and human pathogenic bacteria with antibacterial and antifungal activities, highlighting those currently in pre-clinical trials or with potential for drug development. Selected unusual biosynthetic pathways, the key roles they play (where known) in various ecological niches are described. We also provide an overview of the mode of action (molecular target), activity, and minimum inhibitory concentration (MIC) towards bacteria and fungi. The exploitation of pathogenic bacteria as a rich source of antimicrobials, combined with the recent advances in genomics and natural products research Received 14th August 2020 methodology, could pave the way for a new golden age of antibiotic discovery. This review should serve DOI: 10.1039/d0np00061b as a compendium to communities of medicinal chemists, organic chemists, natural product chemists, rsc.li/npr This article is licensed under a biochemists, clinical researchers, and many others interested in the subject.
    [Show full text]