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List of European Pharmacopoeia Reference Standards Effective from 2015/12/24 Order Reference Standard Batch n° Quantity Sale Information Monograph Leaflet Storage Price Code per vial Unit Y0001756 Exemestane for system suitability 1 10 mg 1 2766 Yes +5°C ± 3°C 79 ! Y0001561 Abacavir sulfate 1 20 mg 1 2589 Yes +5°C ± 3°C 79 ! Y0001552 Abacavir for peak identification 1 10 mg 1 2589 Yes +5°C ± 3°C 79 ! Y0001551 Abacavir for system suitability 1 10 mg 1 2589 Yes +5°C ± 3°C 79 ! Y0000055 Acamprosate calcium - reference spectrum 1 n/a 1 1585 79 ! Y0000116 Acamprosate impurity A 1 50 mg 1 3-aminopropane-1-sulphonic acid 1585 Yes +5°C ± 3°C 79 ! Y0000500 Acarbose 3 100 mg 1 See leaflet ; Batch 2 is valid until 31 August 2015 2089 Yes +5°C ± 3°C 79 ! Y0000354 Acarbose for identification 1 10 mg 1 2089 Yes +5°C ± 3°C 79 ! Y0000427 Acarbose for peak identification 3 20 mg 1 Batch 2 is valid until 31 January 2015 2089 Yes +5°C ± 3°C 79 ! A0040000 Acebutolol hydrochloride 1 50 mg 1 0871 Yes +5°C ± 3°C 79 ! Y0000359 Acebutolol impurity B 2 10 mg 1 -[3-acetyl-4-[(2RS)-2-hydroxy-3-[(1-methylethyl)amino] propoxy]phenyl] 0871 Yes +5°C ± 3°C 79 ! acetamide (diacetolol) Y0000127 Acebutolol impurity C 1 20 mg 1 N-(3-acetyl-4-hydroxyphenyl)butanamide 0871 Yes +5°C ± 3°C 79 ! Y0000128 Acebutolol impurity I 2 0.004 mg 1 N-[3-acetyl-4-[(2RS)-3-(ethylamino)-2-hydroxypropoxy]phenyl] 0871 Yes +5°C ± 3°C 79 ! butanamide Y0000056 Aceclofenac - reference spectrum 1 n/a 1 1281 79 ! Y0000085 Aceclofenac impurity F 2 15 mg 1 benzyl[[[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxy]acetate 1281 Yes +5°C ± 3°C 79 ! Y0000086 Aceclofenac impurity H 1 10 mg 1 [[[[[[[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxy]acetyl] oxy]acetyl]oxy] 1281 Yes +5°C ± 3°C 79 ! acetic acid Y0001094 Aceclofenac for peak identification 1 10 mg 1 1281 Yes +5°C ± 3°C 79 ! Y0000810 Acemetacin 1 100 mg 1 1686 Yes +5°C ± 3°C 79 ! Y0000811 Acemetacin impurity A 1 10 mg 1 4-chlorobenzoic acid 1686 Yes +5°C ± 3°C 79 ! Y0000842 Acemetacin impurity mixture 1 0.06 mg 1 1686 Yes +5°C ± 3°C 79 ! A0070000 Acesulfame potassium 2 50 mg 1 1282 Yes +5°C ± 3°C 79 ! A0070020 Acesulfame potassium impurity B 4 15 mg 1 see leaflet; 5-chloro-6-methyl-1,2,3-oxathiazin-4(3§)-one 2,2-dioxide 1282 Yes +5°C ± 3°C 79 ! A0100000 Acetazolamide 1 100 mg 1 0454 Yes +5°C ± 3°C 79 ! Y0001084 Acetazolamide for system suitability 2 0.0068 mg 1 Batch 1 is valid until 31 May 2015 0454 Yes +5°C ± 3°C 79 ! Y0000002 Acetylcholine chloride 1 50 mg 1 1485,1971 Yes -20°C ± 5°C 79 ! A0150000 Acetylcysteine 3 50 mg 1 0967 Yes +5°C ± 3°C 79 ! A0152000 Acetylcysteine impurity C 9 10 mg 1 See leaflet; N,N'-diacetyl-L-cystine 0967 Yes +5°C ± 3°C 79 ! A0153000 Acetylcysteine impurity D 6 10 mg 1 N,£-diacetyl-L-cysteine ; Batch 5 is valid until 28 May 2015 0967 Yes +5°C ± 3°C 79 ! Y0000565 ß-Acetyldigoxin 2 50 mg 1 See leaflet C÷–HÿÿOŒ— 2168 Yes +5°C ± 3°C 79 ! Y0000642 ß-Acetyldigoxin for peak identification 1 10 mg 1 2168 Yes +5°C ± 3°C 79 ! A0200000 Acetylsalicylic acid 4 15 mg 1 0309 Yes +5°C ± 3°C 79 ! Y0001460 Acetylsalicylic acid for peak identification 2 10.3 mg 1 0309 Yes +5°C ± 3°C 79 ! Y0001462 Acetylsulfadiazine 1 0.002 mg 1 0294 Yes +5°C ± 3°C 79 ! A0208000 N-Acetyltryptophan 2 125 mg 1 1383 Yes +5°C ± 3°C 79 ! © Council of Europe, all rights reserved 2015 1 For extra charges, please see supply terms and conditions. List of European Pharmacopoeia Reference Standards Effective from 2015/12/24 Order Reference Standard Batch n° Quantity Sale Information Monograph Leaflet Storage Price Code per vial Unit A0202000 N-Acetyltyrosine 1 200 mg 1 1384 Yes +5°C ± 3°C 79 ! Y0000693 Acholeplasma laidlawii BRP 1 1 ml 1 20607 Yes -80°C ± 10°C 120 ! A0220000 Aciclovir 3 75 mg 1 0968 Yes +5°C ± 3°C 79 ! Y0001271 Aciclovir for peak identification 1 3 0.303 mg 1 0968 Yes +5°C ± 3°C 79 ! Y0001269 Aciclovir for peak identification 2 3 0.004 mg 1 Batch 2 is valid until 31 December 2014 0968 Yes +5°C ± 3°C 79 ! Y0001264 Aciclovir for system suitability 1 10 mg 1 0968 Yes +5°C ± 3°C 79 ! A0225000 Acitretin 2 100 mg 1 See leaflet CœŒHœÿO– 1385 Yes +5°C ± 3°C 79 ! Y0001463 Actaea racemosa HRS 1 1200 mg 1 2069 Yes +5°C ± 3°C 79 ! Y0001543 Actaea racemosa for assay CRS 1 300 mg 1 See leaflet C÷œHÿ—NOŒÿ; Monoammonium glycyrrhizate 2069 Yes +5°C ± 3°C 79 ! Y0001464 Actaea racemosa dry extract for system suitability HRS 1 1200 mg 1 2069 Yes -20°C ± 5°C 79 ! Y0001121 Adapalene 1 100 mg 1 See leaflet Cœ‡Hœ‡O– 2445 Yes +5°C ± 3°C 79 ! Y0001120 Adapalene impurity C 3 6 mg 1 1-[2-(methyloxy)phenyl]tricyclo[3.3.1.1]decane 2445 Yes +5°C ± 3°C 79 ! Y0001119 Adapalene for peak identification 2 2.022 mg 1 Batch 1 is valid until 31 March 2016 2445 Yes +5°C ± 3°C 79 ! A0230000 Adenine 2 50 mg 1 0800 Yes +5°C ± 3°C 79 ! A0230200 Adenosine 1 50 mg 1 1486 Yes +5°C ± 3°C 79 ! Y0000110 Adipic acid 1 50 mg 1 1586 Yes +5°C ± 3°C 79 ! Y0000882 Adrenaline 1 5 mg 1 2303 Yes +5°C ± 3°C 79 ! Y0000740 Adrenaline impurity mixture 3 0.0045 mg 1 0254,2303 Yes +5°C ± 3°C 79 ! Y0000883 Adrenaline with impurity F 1 10 mg 1 2303 Yes +5°C ± 3°C 79 ! A0300000 Adrenaline tartrate 5 100 mg 1 0254 Yes +5°C ± 3°C 79 ! Y0000707 Adrenaline tartrate with impurity A 1 15 mg 1 0254 Yes +5°C ± 3°C 79 ! Y0001724 Agnus castus fruit dry extract 1 350 mg 1 see leaflet 2309, 2147 Yes -20°C ± 5°C 79 ! A0325000 Alanine 3 60 mg 1 0752 Yes +5°C ± 3°C 79 ! A0325100 Albendazole 2 50 mg 1 Batch 1 is valid until 31 December 2015 1386 Yes +5°C ± 3°C 79 ! A0325200 Alcuronium chloride 2 50 mg 1 1285 Yes -20°C ± 5°C 79 ! A0325450 Alfacalcidol 9 5 mg 1 See leaflet ; Batch 8 is valid until 31 October 2015 1286 Yes -20°C ± 5°C 300 ! Y0001601 Alfacalcidol for system suitability 1 2.5 mg 1 1286 Yes -20°C ± 5°C 79 ! A0325451 Alfacalcidol - reference spectrum 1 n/a 1 1286 79 ! A1225000 Alfadex 3 150 mg 1 See leaflet [CÿHŒ!0—]ÿ 1070,1487 Yes +5°C ± 3°C 79 ! A0325500 Alfentanil hydrochloride - reference spectrum 1 n/a 1 1062 79 ! A0325800 Alfuzosin hydrochloride 2 10 mg 1 1287 Yes +5°C ± 3°C 79 ! Y0000832 Alfuzosin for system suitability 1 10 mg 1 1287 Yes +5°C ± 3°C 79 ! Y0001583 Alimemazine hemitartrate 1 15 mg 1 2650 Yes +5°C ± 3°C 79 ! Y0001581 Alimemazine for system suitability 1 5 mg 1 2650 Yes +5°C ± 3°C 79 ! A0349000 Allantoin 1 60 mg 1 1288 Yes +5°C ± 3°C 79 ! A0350000 Allopurinol 3 100 mg 1 See leaflet ; Batch 2 is valid until 31 October 2015 0576 Yes +5°C ± 3°C 79 ! © Council of Europe, all rights reserved 2015 2 For extra charges, please see supply terms and conditions. List of European Pharmacopoeia Reference Standards Effective from 2015/12/24 Order Reference Standard Batch n° Quantity Sale Information Monograph Leaflet Storage Price Code per vial Unit A0350010 Allopurinol impurity A 2 10 mg 1 5-amino-1H-pyrazole-4-carboxamide 0576 Yes +5°C ± 3°C 79 ! A0350020 Allopurinol impurity B 3 10 mg 1 5-formylamino-1H-pyrazole-4-carboxamide 0576 Yes +5°C ± 3°C 79 ! A0350030 Allopurinol impurity C 3 10 mg 1 5-(4H-1,2,4-triazol-4-yl)-1H-pyrazole-4-carboxamide 0576 Yes +5°C ± 3°C 79 ! A0350040 Allopurinol impurity D 4 15 mg 1 ethyl 5-amino-1H-pyrazole-4-carboxylate ; Batch 3 is valid until 30 September 0576 Yes +5°C ± 3°C 79 ! 2015 A0350050 Allopurinol impurity E 1 20 mg 1 ethyl 5-(formylamino)-1H-pyrazole-4-carboxylate 0576 Yes +5°C ± 3°C 79 ! A0351000 Allylstrychnine bromide 1 10 mg 1 1285 Yes -20°C ± 5°C 79 ! Y0000235 Almagate 1 25 mg 1 See leaflet 2010 Yes +5°C ± 3°C 79 ! Y0000255 Almagate - reference spectrum 1 n/a 1 2010 79 ! A0357000 Alprazolam - * psy 2 100 mg 1 1065 Yes +5°C ± 3°C 79 ! A0360000 Alprenolol hydrochloride 1 100 mg 1 0628,0876 Yes +5°C ± 3°C 79 ! Y0000054 Alprostadil 2 50 mg 1 see leaflet 1488 Yes -20°C ± 5°C 79 ! Y0000606 Altizide 2 150 mg 1 See leaflet CŒŒHŒ÷ClN–O÷S– 0370,2185 Yes +5°C ± 3°C 79 ! Y0000843 Altizide impurity B 1 15 mg 1 3-[(2,2-dimethoxyethyl)sulphanyl]prop-1-ene 2185 Yes +5°C ± 3°C 79 ! Y0000687 Alverine citrate 1 5 mg 1 2156 Yes +5°C ± 3°C 79 ! Y0000607 Alverine impurity D 1 10 mg 1 N-(3-cyclohexylpropyl)-N-ethyl-3-phenylpropan-1-amine 2156 Yes +5°C ± 3°C 79 ! Y0000595 Alverine for peak identification 2 0.125 mg 1 2156 Yes -20°C ± 5°C 79 ! A0363000 Amantadine hydrochloride 1 100 mg 1 0463 Yes +5°C ± 3°C 79 ! A0363700 Ambroxol hydrochloride 3 125 mg 1 1489 Yes +5°C ± 3°C 79 ! A0900000 Amfetamine sulfate - reference spectrum 1 n/a 1 0368 79 ! A0365000 Amidotrizoic acid dihydrate 1 100 mg 1 0873 Yes +5°C ± 3°C 79 ! Y0001461 Amidotrizoic acid for system suitability 1 0.08 mg 1 0873 Yes +5°C ± 3°C 79 ! A0368000 Amikacin 3 200 mg 1 See leaflet 1289,1290 Yes +5°C ± 3°C 79 ! Y0001467 Amikacin impurity I 1 20 mg 1 (2S)-4-amino-2-hydroxybutanoic acid 1289, 1290 Yes +5°C ± 3°C 79 ! New Y0001117 Amikacin for system suitability 3 10 mg 1 1289,1290 Yes +5°C ± 3°C 79 ! A0365900 Amikacin sulfate 3 200 mg 1 The batch 3 is not suitable for use in the assay in monograph 1290:07/2014.
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  • 8Th European Congress on Epileptology, Berlin, Germany, 21 – 25 September 2008

    8Th European Congress on Epileptology, Berlin, Germany, 21 – 25 September 2008

    Epilepsia, 50(Suppl. 4): 2–262, 2009 doi: 10.1111/j.1528-1167.2009.02063.x 8th ECE PROCEEDINGS 8th European Congress on Epileptology, Berlin, Germany, 21 – 25 September 2008 Sunday 21 September 2008 KV7 channels (KV7.1-5) are encoded by five genes (KCNQ1-5). They have been identified in the last 10–15 years by discovering the caus- 14:30 – 16:00 ative genes for three autosomal dominant diseases: cardiac arrhythmia Hall 1 (long QT syndrome, KCNQ1), congenital deafness (KCNQ1 and KCNQ4), benign familial neonatal seizures (BFNS, KCNQ2 and VALEANT PHARMACEUTICALS SATELLITE SYM- KCNQ3), and peripheral nerve hyperexcitability (PNH, KCNQ2). The fifth member of this gene family (KCNQ5) is not affected in a disease so POSIUM – NEURON-SPECIFIC M-CURRENT K+ CHAN- far. The phenotypic spectrum associated with KCNQ2 mutations is prob- NELS: A NEW TARGET IN MANAGING EPILEPSY ably broader than initially thought (i.e. not only BFNS), as patients with E. Perucca severe epilepsies and developmental delay, or with Rolando epilepsy University of Pavia, Italy have been described. With regard to the underlying molecular pathophys- iology, it has been shown that mutations in KCNQ2 and KCNQ3 Innovations in protein biology, coupled with genetic manipulations, have decrease the resulting K+ current thereby explaining the occurrence of defined the structure and function of many of the voltage- and ligand- epileptic seizures by membrane depolarization and increased neuronal gated ion channels, channel subunits, and receptors that are the underpin- firing. Very subtle changes restricted to subthreshold voltages are suffi- nings of neuronal hyperexcitability and epilepsy. Of the currently cient to cause BFNS which proves in a human disease model that this is available antiepileptic drugs (AEDs), no two act in the same way, but all the relevant voltage range for these channels to modulate the firing rate.
  • Difference Between Patient-Reported Side Effects of Ciclesonide Versus fluticasone Propionate

    Difference Between Patient-Reported Side Effects of Ciclesonide Versus fluticasone Propionate

    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Respiratory Medicine (2010) 104, 1825e1833 available at www.sciencedirect.com journal homepage: www.elsevier.com/locate/rmed Difference between patient-reported side effects of ciclesonide versus fluticasone propionate Thys van der Molen a, Juliet M. Foster a,b, Manfred Caeser c,e, Thomas Mu¨ller c, Dirkje S. Postma d,* a Department of General Practice, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands b Woolcock Institute of Medical Research, 431 Glebe Point Rd, Glebe NSW 2037, Sydney, Australia c Nycomed GmbH, Byk-Gulden-Straße 2, 78467 Konstanz, Konstanz, Germany d Department of Pulmonary Diseases, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands Received 18 January 2010; accepted 26 May 2010 Available online 2 July 2010 KEYWORDS Summary Adverse events; Rationale: Patient-reported outcomes provide new insights into the dynamics of asthma Inhaled corticosteroid management. Further to asthma control and quality of life, self-reported side effects of treat- questionnaire; ment can be assessed with the validated Inhaled Corticosteroid Questionnaire (ICQ). ICQ; Objectives: To compare patient-reported side effects between the inhaled corticosteroids Patient-reported ciclesonide and fluticasone propionate. outcomes Methods: Patients with moderate or moderate-to-severe asthma, pre-treated with a constant dose and type of medication, were randomized in three separate studies: 1) once daily cicle- sonide 320 mg(n Z 234) or twice daily fluticasone propionate 200 mg(n Z 240); 2) twice daily ciclesonide 320 mg(n Z 255) or twice daily fluticasone propionate 375 mg(n Z 273); and 3) twice daily ciclesonide 320 mg(n Z 259) or twice daily fluticasone propionate 500 mg (n Z 244).