Association Between Physical Activity and Risk of Bleeding in Children with Hemophilia

Home , Diving (sport), Lifesaving, Rafting, Trampolining

Supplementary Online Content

Broderick CR, Herbert RD, Latimer J, et al. Association Between Physical Activity and Risk of Bleeding in Children With Hemophilia. JAMA. doi:10.1001/jama.2012.12727.

eTable 1. Physical Activity Types, Categories and Examples

eTable 2. Sensitivity Analyses

This supplementary material has been provided by the authors to give readers additional information about their work.

Downloaded From: https://jamanetwork.com/ on 09/25/2021 eTable 1. Physical Activity Types, Categories and Examples Activity types Activity Examples category Inactive 0 eating, playing music except drums, lying down, reading, watching television, computer time, Playstation, PSP, Nintendo, bathing, dentist/doctor appointments, getting dressed, getting out of car, homework, talking on phone, board games Home duties 0 vacuuming, cleaning, dusting, sweeping, cooking, painting, gardening, lawn mowing, shopping, picking up rubbish, work duties-McDonalds etc Walking/jogging/ 1 walking for transport, walking for recreation, jogging, sprint races, long sprinting distance running, marching, athletics, bushwalking, cross country running Swimming 1 freestyle, breaststroke, butterfly, backstroke, kickboard, treading water Light play 1 playing with friends, building cubby house, playing with dog, playing with blocks, drumming, Wii fit or Wii sports, jumping, slippery dip, see-saw, frisbee, skipping, hula hoop, swing, push, card games, laser zone, theme parks Non-contact sports 1 archery, darts, lawn bowls, golf, fishing, tai chi, pool, snooker, table tennis, marbles, badminton, ten pin bowling Dancing 1 hip hop, jazz, ballroom, contemporary, Latin American, Irish, Scottish, folk dancing Gym activities 1 lifting weights, gym equipment, cardio, rowing ergometer, stretching, physiotherapy exercises PE unspecified 1 school PE lessons Unstructured non-contact ball 1 handball, two square, throwing, catching, kicking games Structured throwing activities 1 shot put, javelin, discus, Water activities (low risk) 1 swimming in surf, sailboarding, nippers, snorkeling, scuba diving, boogie boarding, rowing, canoeing, lifesaving Water activities (mod risk) 2 surfing, skim boarding, surf lifesaving, waterskiing, comp diving, water slides, white water rafting, sailing, Unstructured park/playground 2 jumping castle, trampolining, climbing, tug-o-war, climbing trees, swinging activities from ropes, playing on play equipment Gymnastics 2 artistic, rhythmic, acrobatics, competitive trampolining Riding activities (low risk) 2 bike riding, track & road cycling, riding scooter, riding horse, motor bike riding, rollerblading, roller-skating, BMX lite Wilderness 2 rock climbing, abseiling, chopping wood Hard ball games/training 2 baseball, softball, cricket, t-ball Running games/jumping 2 running games, chasings, tiggy, long jump, high jump, hurdles Racquet sports 2 tennis, squash, Mod-low contact sports 2 soccer, netball, basketball, touch football, Oz tag, water polo, volleyball, European handball, field hockey, football umpire, school sport Snow sports 3 skiing, ice-skating, tobogganing, snowboarding, Martial arts 3 karate, Kung Fu, Tae Kwon Do, Judo, boxercise, 30-30 boxing drill Contact/collision sports 3 tackle football including rugby union, rugby league, AFL, American football, ice hockey, wrestling, boxing Motor sports 3 motocross Riding activities (mod risk) 3 skateboarding, rip-stick, BMX hard core Rough play 3 wrestling, dodge ball, brandings, rumbling, slap boxing, rough housing

* Reproduced from Haemophilia (Broderick CR, Herbert RD, Latimer J, van Doorn N. Patterns of physical activity in children with haemophilia. Haemophilia. 2012;DOI 10.1111/j.1365-2516.2012.02904.x)

Downloaded From: https://jamanetwork.com/ on 09/25/2021 eTable 2. Sensitivity Analyses

With multiple imputation Excluding children with Excluding waking bleeds of missing data inhibitors

OR 95% CI OR 95% CI OR 95% CI

Category 2 2.7 1.7 to 4.3 2.7 1.8 to 4.7 2.7 1.7 to 4.5

Category 3 3.7 1.8 to 8.0 3.8 2.2 to 7.7 3.5 2.0 to 6.9

Clotting 0.980 0.970 to 0.991 0.980 0.962 to 0.991 0.981 0.966 to 0.992 factor level

Data are odds ratios. Results of three sensitivity analyses are shown. Rates are referenced to the rate of bleeding

while inactive or engaging in Category 1 activity with a factor level of 0.

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