Physiology of Adventure Racing – with Emphasis on Circulatory Response and Cardiac Fatigue
From the Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden PHYSIOLOGY OF ADVENTURE RACING – WITH EMPHASIS ON CIRCULATORY RESPONSE AND CARDIAC FATIGUE C. Mikael Mattsson Stockholm 2011 Supervisors Main supervisor Björn Ekblom, M.D., Ph.D., Professor emeritus Åstrand Laboratory of Work Physiology The Swedish School of Sport and Health Sciences, Stockholm, Sweden Co-supervisor Bo Berglund, M.D., Ph.D., Associate professor Department of Medicine Karolinska Institutet, Stockholm, Sweden External mentor Euan A. Ashley, M.D., Ph.D., Assistant professor Department of Medicine Stanford University, CA, USA Faculty Opponent Keith P. George, Ph.D., Professor Research Institute for Sport and Exercise Sciences Liverpool John Moores University, Liverpool, England Examination Board Eva Nylander, M.D., Ph.D., Professor Department of Medical and Health Sciences Linköping University, Linköping, Sweden Tomas Jogestrand, M.D., Ph.D., Professor Department of Laboratory Medicine Karolinska Institutet, Stockholm, Sweden Mats Börjesson, M.D., PhD., Associate professor Department of Emergency and Cardiovascular Medicine University of Gothenburg, Gothenburg, Sweden Front cover: Explore Sweden 2010. Photo: Krister Göransson. All previously published papers were reproduced with permission from the publisher. Published by Karolinska Institutet. Printed by Larserics Digital Print AB. © C. Mikael Mattsson, 2011 ISBN 978-91-7457-262-9 “We'll go because it's Thursday, and we'll go to wish everybody a Very Happy Thursday.” Winnie-the-Pooh 1 ABSTRACT The overall aims of this thesis were to elucidate the circulatory responses to ultra-endurance exercise (Adventure Racing), and furthermore, to contribute to the clarification of the so called “exercise-induced cardiac fatigue” in relation to said exercise.
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