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2019 RiboClub Program
RNA: 20 Years of Discoveries

In Association with the Gairdner Foundation

September 22-27 -   Hotel Chéribourg, Orford, Québec, Canada
Organizing Committee: Allan Jacobson, Robert Singer, Adrian Krainer, Françoise Stutz, Yukihide Tomari, Sandra Wolin, Nehalkumar Thakor (ARRTI co-organizer for western
Canada) and the RiboClub.

Sunday, September 22, 2019 (Day1)

15:00 – 20:00 Registration / Coffee and cake 17:00 – 17:10 Welcome notes and Announcements
Sherif Abou Elela

RiboClub organizer and co-founder, Member of the   Université de Sherbrooke RNA Group

17:15 – 17:45 Opening Lecture I: RNA Biology: Origins and Reflections
Joan Steitz Sterling Professor of Molecular Biophysics and Biochemistry, Yale University First speakers of the RiboClub 1998

17:45 – 18:15 Opening Lecture II: RNA Biology: History of Discoveries
Witold Filipowicz

Professor of Biochemistry, Friedrich Miescher Institute for Biomedical Research

18:15 – 18:45 Special presentation by the recipient of the RiboClub 2009 life achievement award: Initiating the study of Initiation: Initiating translation initiation: a short history and perspective Nahum Sonenberg, Member of the RiboClub, Gilman Cheney Chair in Biochemistry, McGill University

18:45 – 19:45 Cocktail and social time 19:45 – 19:50 Introduction of members of the community and dignitaries
Raymund Wellinger

Master of ceremonies, Co-founder of the Université de Sherbrooke RNA group,

19:50 – 19:50 Welcome note
Pierre Cossette President, Université de Sherbrooke
19:50 – 20:45 Networking Dinner 20:45 – 20:55 Student Recognition and Travel Awards
Eric Masse

RiboClub Member, Université de Sherbrooke.

20:45 – 20:50 RNA studies at the Université de Sherbrooke
Nathalie Rivard

Vice Dean Research, Graduate Studies and Innovation, Faculty of Medicine and Health Sciences, Université de Sherbrooke

20:50 – 21:00 RNA Biology in Canada and the Training of Future Professionals
Hans-Joachim Wieden

Director, Alberta RNA Research and Training Institute University of Lethbridge

21:00 – 23:30 Get Together

Monday, September 23, 2019 (Day2) Public session: Introduction 9:00 – 9:10 Highlights of the RiboClub 2019

Sherif Abou Elela

RiboClub organizer and co-founder, Member of the   Université de Sherbrooke RNA Group

9:10 –9:15. Gairdner Foundation Supporting Excellence in RNA Biology

Janet Rossant

President and Scientific Director, Gairdner Foundation

Public session: The RiboClub and the Societal Impact of RNA Research

Host: Michelle Scott, Member of the   Université de Sherbrooke RNA group

9:15 – 9:25 Riboclub: Building an RNA Community to Trigger Discoveries

Benoit Chabot

Co-founder of the Université de Sherbrooke RNA group

9:25 –9:30 The RiboClub: A Training Playground for Future Researchers

Jonathan Perreault

Former students’ representative, 2017 Alumnus of the year, member of the RiboClub, Professor at INRS-Institute Armand-Frappier

9:30 –9:35 Role of Institutions in Supporting and Developing RNA Based Research

Jean-Pierre Perreault

Vice-President Research and Graduated Studies, co-founder of the Université de Sherbrooke RNA group

9:35 –9:40 Funding RNA Research to Improve Healthcare

Michael Strong

President, Canadian Institutes for Health Research (CIHR)

9:40 –9:45 The Outlook for Basic Research in Canada

Mona Nemer

Chief Science Advisor of the Government of Canada

9:45 - 10:00 Open Questions and Panel Discussion

Moderators: Martin Simard, 2004 Alumnus of the year, Université Laval and Thomas Duchaine, 2012 Alumnus of the year, McGill University

Participants: Sherif Abou Elela, Benoit Chabot, Jean-Pierre Perreault, Janet Rossant, Michael Strong, Mona Nemer, Jonathan Perreault

10:00 – 10:30 Coffee break and social time

Public Session: RNA Based Discoveries and Impact

Presenter: Stephen Rader

RiboClub member, University of Northern British   Columbia

10:30 –10:50 Re-Writing Genomes with CRISPR RNAs

Erik Sontheimer

The RNA Therapeutic Institute, University of Massachusetts Medical School, Founder of Intellia Therapeutics Inc. Developer of CRISPR-based therapy.

10:50 - 11:10 Genetic Nonsense: From Bench to Bedside and Back to the Bench

Allan Jacobson

Chair of the Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Professor of Pathology and Cell biology, Founder of Applied biotechnology Inc and Founder and Director of PTC Therapeutics Inc. Developer of Translarna as treatment for Duchenne Muscular Dystrophy

11:10 - 11:30 RNA Splicing: From Discovery to Treatment

Adrian Krainer

St. Giles Foundation Professor at Cold Spring Harbor Laboratory, Laureate of Life Sciences Breakthrough Prize 2019, Founder and Director of Stoke Therapeutics Inc., Inventor of   Spinraza, the first approved drug for spinal muscular atrophy

11:30 –12:00 Panel Discussion and Questions

Moderator: Katherine Borden

Canada Research Chair, Professor of Pathology and Cell biology, Université de Montréal

Panel Participants: Adrian Krainer, Erik Sontheimer, Allan Jacobson
End of public session and departure of unregistered guests

Scientific Meeting

13:00 - 14:00 Lunch for registered guests

Session 1: RNA Silencing

Chair: Victor Ambros 14:00 - 14:15 Victor Ambros
Introduction and history

14:15 - 14:30 Michael McManus 14:30 - 14:45 Yukihide Tomari 14:45 - 15:00 Lin He 15:00 - 15:15 Olivia Rissland 15:15 - 15:25 Selection from abstract 15:25 - 15:35 Selection from abstract 15:35 – 16:05 Questions and panel discussions
Moderator: Muthiah Manoharan, Alnylam Pharmaceuticals

16:05 - 16:25 Coffee Break

Session 2: RNA editing, modification and transcriptomics

Session Chair: Brenda Bass 16:25 - 16:40 Brenda Bass
Introduction and history

16:40 - 16:55 Tsutomu Suzuki 16:55 - 17:10 Wendy Gilbert 17:10 - 17:25 Pierre Close 17:25 - 17:40 Chuan He 17:40 - 17:50 Selection from abstract 17:50 – 18:00 Selection from abstract 18:00 – 18:30 Questions and panel discussion
Moderator: Valerie A. De Crecy-Lagard

18:30 – 21:00 Dinner

21:00 – 22:00 Get Together

Tuesday September 24, 2019 (Day 3)

07:00 - 08:00 Breakfast

Session 3: Bacterial RNA

Chair: Susan Gottesman 08:00 - 08:15 Susan Gottesman 08:15 - 08:30 Jörg Vogel 08:30 - 08:45 Eric Masse
Introduction and history
08:45 - 09:00 Lydia Contreras 09:00 - 09:15 Cynthia Sharma

09:15 - 09:25 Selection from abstract 09:25 - 09:35 Selection from abstract 09:35 - 10:05 Questions and panel discussion
Moderator: Sarah Woodson

10:05 – 10:35 Coffee Break

Session 4A: Non-coding RNA

Chair: David Bartel 10:35 - 10:50 David Bartel
Introduction and history

10:50 - 11:05 Wade Winkler 11:05 - 11:20 Sherif Abou Elela 11:20 - 11:35 Alena Shkumatava 11:35 - 11:50 Lingling Chen 11:50 - 12:00 Selection from abstract 12:00 - 12:10 Selection from abstract 12:10– 12:40 Questions and panel discussion
Moderator: TBD

12:40 - 14:00 Mentor mentee Lunch

Session 4B: Non-coding RNA

Chair: Kathy Collins 14:00 - 14:15 Introduction and history
Kathy Collins

14:15 - 14:30 Claus Azzalin 14:30 - 14:45 Jorgen Kjems 14:45 - 15:00 Howard Chang 15:00 - 15:15 Anton Petrov 15:15 - 15:25 Selection from abstract 15:25 - 15:35 Selection from abstract 15:35 – 16:05 Questions and panel discussion
Moderator: Raymund Wellinger

16:05 – 16:35 Coffee break

Session 5: Ribosome structure and function

Chair: Joachim Frank 16:35 - 16:50 Introduction and history
Joachim Frank

16:50 - 17:05 Marat Yusupov 17:05 - 17:20 Andrei Korostelev 17:20 - 17:35 Jamie Williamson 17:35 - 17:45 Selection from abstract 17:45 - 17:55 Selection from abstract 17:55 – 18:25 Questions and panel discussion
Moderator: Gloria Culver

18:25 - 18:45 Students’ Poster Promotion Micro talks (2 minutes talks by students)
Host: Daniel Lafontaine

18:45 - 19:45 Dinner 19:45 - 21:45 Poster Session I 21:45 - 23:00 Get Together

Wednesday September 25, 2019 (Day 4)

07:00 - 08:00 Breakfast

Session 6: Spliceosome structure and dynamics

Chair: Reinhardt Lührmann 08:00 - 08:15 Reinhardt Lührmann: Introduction and history

08:15 - 08:30 Dan Larson 08:30 - 08:45 Kiyoshi Nagai 08:45 - 09:00 Doug Black 09:00- 09:15 Manny Ares 09:15 - 09:25 Selection from abstract 09:25 - 09:35 Selection from abstract 09:35 - 10:05 Questions and panel discussions
Moderator: Chris Trotta
10:05 - 10:35 Coffee Break

Session 7: RNA decay and surveillance

10:35 - 10:50 Introduction and history
Allan Jacobson

10:50 - 11:05 Lori Passmore 11:05 - 11:20 Torben Heick Jensen 11:20 - 11:35 Lynne Maquat 11:35- 11:50 Jianjun Chen 11:50 - 12:00 Selection from abstract 12:00 - 12:10 Selection from abstract 12:10 - 12:40 Questions and panel discussion (applications and future)
Moderator: Kristian Baker

12:40 – 12:55 Group photo 12:55 – 14:40 Lunch 14:40 – 16:40 Poster session II 16:40 – 19:00 Free afternoon

19:00 - 20:30 Dinner

20:30 - 20:40 The blue jacket awardees.
Martin Bisaillon

20:40 - 20:50 Poster awards presentation by Michelle Scott 20:50 - 21:10 RNA biology: the early days
Marvin Wickens

Max Perutz Professor of Molecular Biology and Biochemistry, University of Wisconsin

Introduction by Mark Schmitt, SUNY Upstate Medical University

21:30 - 23:00 Get together Thursday September 26, 2019 (Day 5)

07:00 - 08:00 Breakfast

Session 8: RNA and Immunity

Session Chair: Sandra Wolin 8:00 - 8:15 Sandra Wolin

Introduction and history

8:15 - 8:30 Daniel Stetson 8:30 - 8:45 Uttiya Basu 8:45 -9:00 Karla Kirkegaard 9:00 - 9:15 Selection from abstract 9:15 - 9:25 Selection from abstract 9:25 - 9:35 Selection from abstract 9:35 - 10:05 Questions and panel discussion
Moderator: Jonathan Yingling,

10:05 - 10:35 Coffee Break

Session 9: Alternative splicing mechanisms and regulation

Chair: John Mattick 10:35 - 10:50 John Mattick: Introduction and history

10:50 - 11:05 Benoit Chabot 11:05 - 11:20 Ben Blencowe 11:20 - 11:35 Kristen Lynch 11:35 - 11:50 Karla Neugebauer 11:50 - 12:00 Selection from abstract 12:00 - 12:10 Selection from abstract 12:10 - 12:40 Questions and Panel discussion (applications and future)
Moderator: TBD

12:40 - 14:40 Lunch

Session 10: RNA granules and droplets

Chair: Roy Parker 14:40 - 14:55 Roy Parker 14:55 - 15:10 Mark Ashe 15:10 - 15:25 Graciela L. Boccaccio 15:25 - 15:40 Ross Buchan 15:40 - 15:50 Selection from abstract 15:50 - 16:00 Selection from abstract 16:00 - 16:30 Questions and Panel discussion (applications and future)
Moderator: Rachel Meyers

16:30 - 17:00 Coffee break

Session 11: RNA structure, evolution, aptamer and catalytic RNA

Chair: Larry Gold 17:00 - 17:15 Larry Gold 17:15 - 17:30 Jack Szostak 17:30 - 17:45 Adrian R. Ferré-D’Amare 17:45 - 18:00 Alan Lambowitz 18:00 - 18:15 David Mathews 18:15 - 18:45 Questions and panel discussion
Moderator: TBD
18:45 – 19:20 Students choice special presentation Andrew Fire

19:30 - 20:30 Closing Gala and Awards Ceremony

Host: Francois Bachand, Director of the Université de Sherbrooke Center of RNA Biology, member of Université de Sherbrooke RNA group

20:30 - 20:35 The Dean’s Notes

Dominque Dorion Dean, Faculty of Medicine and Health Sciences, Université de Sherbrooke

20:35 - 21:10 Special presentation of a lifetime of RNA biology

Phillip Sharp

Professor, Koch Institute for Integrative Cancer Research at MIT

Introduction by Andrew McMillan, Member of the RiboClub, University of Alberta

21:10 - 21:20 Presentation of the life achievement award

Nahum Sonnenberg

James McGill Professor of Biochemistry, McGill University and HHMI senior international research scholar,

21:20 - 21:25 Predicting the future, Closing Remarks

Benoit Chabot, co-founder of Université de Sherbrooke RNA group

21:25 - 23:30 Entertainment and Music show

Brendan Bell, Member of the Université de Sherbrooke RNA group

  • 23:30 -
  • Dance

Friday September 27, 2019 (Day 6)

07:00 - 09:00 Breakfast

Departure

Recommended publications
  • Watching Dynamics and Assembly of Spliceosomal

    Watching Dynamics and Assembly of Spliceosomal

    WATCHING DYNAMICS AND ASSEMBLY OF SPLICEOSOMAL COMPLEXES AT SINGLE MOLECULE RESOLUTION A thesis submitted for the degree of DOCTOR OF PHILOSOPHY 2015 CHANDANI MANOJA WARNASOORIYA Section of Virology, Department of Medicine Imperial College London 1 Copyright Declaration The copyright of this thesis rests with the author and is made available under a Creative Commons Attribution Non-Commercial No Derivatives licence. Researchers are free to copy, distribute or transmit the thesis on the condition that they attribute it, that they do not use it for commercial purposes and that they do not alter, transform or build upon it. For any reuse or redistribution, researchers must make clear to others the licence terms of this work. 2 Declaration of Origin I hereby declare that this project was entirely my own work (except the gel images in figures 4.2-4.5 in the chapter 4) and that any additional sources of information have been properly cited. I hereby declare that any internet sources, published and unpublished works from which I have quoted or drawn reference have been referenced fully in the text and in the reference list. I understand that failure to do so will result in failure of this project due to plagiarism. Chapter 3 was in collaboration with Prof. Samuel Butcher and Prof. David Brow at University of Wisconsin-Madison, Wisconsin, USA. The Prp24 full length protein and the truncated protein (234C) were provided by them. Chapter 4 was in collaboration with Prof. Kiyoshi Nagai and his lab members Dr. John Hardin and Yasushi Kondo at LMB Cambridge University, Cambridge, UK.
  • Structural and Functional Characterization of the N-Terminal Acetyltransferase Natc

    Structural and Functional Characterization of the N-Terminal Acetyltransferase Natc

    Structural and functional characterization of the N-terminal acetyltransferase NatC Inaugural-Dissertation to obtain the academic degree Doctor rerum naturalium (Dr. rer. nat.) submitted to the Department of Biology, Chemistry, Pharmacy of Freie Universität Berlin by Stephan Grunwald Berlin October 01, 2019 Die vorliegende Arbeit wurde von April 2014 bis Oktober 2019 am Max-Delbrück-Centrum für Molekulare Medizin unter der Anleitung von PROF. DR. OLIVER DAUMKE angefertigt. Erster Gutachter: PROF. DR. OLIVER DAUMKE Zweite Gutachterin: PROF. DR. ANNETTE SCHÜRMANN Disputation am 26. November 2019 iii iv Erklärung Ich versichere, dass ich die von mir vorgelegte Dissertation selbstständig angefertigt, die benutzten Quellen und Hilfsmittel vollständig angegeben und die Stellen der Arbeit – einschließlich Tabellen, Karten und Abbildungen – die anderen Werken im Wortlaut oder dem Sinn nach entnommen sind, in jedem Einzelfall als Entlehnung kenntlich gemacht habe; und dass diese Dissertation keiner anderen Fakultät oder Universität zur Prüfung vorgelegen hat. Berlin, 9. November 2020 Stephan Grunwald v vi Acknowledgement I would like to thank Prof. Oliver Daumke for giving me the opportunity to do the research for this project in his laboratory and for the supervision of this thesis. I would also like to thank Prof. Dr. Annette Schürmann from the German Institute of Human Nutrition (DifE) in Potsdam-Rehbruecke for being my second supervisor. From the Daumke laboratory I would like to especially thank Dr. Manuel Hessenberger, Dr. Stephen Marino and Dr. Tobias Bock-Bierbaum, who gave me helpful advice. I also like to thank the rest of the lab members for helpful discussions. I deeply thank my wife Theresa Grunwald, who always had some helpful suggestions and kept me alive while writing this thesis.
  • Crystal Structures of Two Sm Protein Complexes and Their Implications for the Assembly of the Spliceosomal Snrnps

    Crystal Structures of Two Sm Protein Complexes and Their Implications for the Assembly of the Spliceosomal Snrnps

    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Cell, Vol. 96, 375±387, February 5, 1999, Copyright 1999 by Cell Press Crystal Structures of Two Sm Protein Complexes and Their Implications for the Assembly of the Spliceosomal snRNPs Christian Kambach,* Stefan Walke,* Robert Young,*§ RNA±RNA interactions to allow the trans-esterification Johanna M. Avis,*k Eric de la Fortelle,* reactions to occur (Moore et al., 1993; Nilsen, 1994). Veronica A. Raker,² Reinhard LuÈ hrmann,² The snRNPs are named after their RNA components: Jade Li,* and Kiyoshi Nagai*³ the U1, U2, U4/U6, and U5 snRNPs contain U1, U2, U4/ *MRC Laboratory of Molecular Biology U6, and U5 small nuclear RNAs (snRNAs), respectively. Hills Road Their protein components are classified into two groups: Cambridge CB2 2QH specific proteins such as U1A, U1 70K, U2B99, and U2A9, England present only in a particular snRNP, and the core proteins ² Institut fuÈ r Molekularbiologie und Tumorforschung common to U1, U2, U4/U6, and U5 snRNPs (LuÈ hrmann Philipps-UniversitaÈ t Marburg et al., 1990; Nagai and Mattaj, 1994). In the spliceosomal Emil-Mannkopff Strabe2 snRNPs from HeLa cell nuclear extract, seven core pro- D-35037 Marburg teins, referred to as the B/B9,D1,D2,D3,E,F,andG Germany proteins, have been identified. The core proteins are also called the Sm proteins due to their reactivity with autoantibodies of the Sm serotype from patients with Summary systemic lupus erythematosus (Lerner and Steitz, 1979). The Sm proteins form a distinct family characterized The U1, U2, U4/U6, and U5 small nuclear ribonucleo- by a conserved Sm sequence motif in two segments, protein particles (snRNPs) involved in pre-mRNA splic- Sm1 and Sm2, separated by a linker of variable length ing contain seven Sm proteins (B/B9,D1,D2,D3,E,F, (Cooper et al., 1995; Hermann et al., 1995; Se raphin, and G) in common, which assemble around the Sm 1995) (Figure 1A).
  • The Completion of John Bradfield Court and New Studentships: with Grateful Thanks to Darwinians Worldwide

    The Completion of John Bradfield Court and New Studentships: with Grateful Thanks to Darwinians Worldwide

    WINTER 2019/20 DarwinianTHE The completion of John Bradfield Court and new studentships: with grateful thanks to Darwinians worldwide A New Portrait John Bradfield Court Nobel Laureate Eric Maskin is interviewed by Andrew Prentice NewS FOR THE DArwin COLLEGE COMMUNITY A Message from Mary Fowler Master Above: even wonderful years ago I followed someone who makes the world better. A wonderful The College’s new portrait Willy Brown as Master of Darwin. As you man, Willy is deeply missed not just here in Darwin, of Mary Fowler at its unveiling, with that of her may know, he died very unexpectedly in in Cambridge and in the UK, but around the world. predecessor Willy Brown August. Much-loved as Master, Willy was He gave his skills and knowledge freely. Fortunate behind. distinguished in labour economics and were those who worked with him, or were taught or industrial relations and a founder of the tutored by him, who experienced his generosity and Low Pay Commission. His work, which friendship. A full tribute to him is on page 10. was characterised by the use of statistics, and careful research, centred around the concept of Now I’m myself in my last year as Master (but S“fairness”. That reflected his own nature, modest, fair, certainly not my last year in Cambridge). September generous, kind, a man of integrity. He was a mediator, saw a ritual – the unveiling of my portrait. Darwin DarwinianTHE 2 members and friends gathered in the Dining Hall where the portrait was waiting, covered. Portraits “A wonderful man, Willy Brown is can be a controversial matter.
  • Darwinianthe

    Darwinianthe

    WINTER 2018/19 DarwinianTHE From the ends of chromosomes to the food of the future: outstanding research by Darwinians Nobel Laureate and Alumna Elizabeth Blackburn is interviewed by Ron Laskey Possibility of vaccine for Ebola Sustainable food of the future NewS FOR THE DArwin COLLEGE COMMUNITY A Message from Mary Fowler Master 2018 has been a year of espite this year’s intemperate weather, Darwin, our students and Fellows have extremes, February and benefitted from and flourished within March saw biting cold wind our strong community of scholars. and rain for many weeks – the Students and Fellows appreciate the diversity of disciplines and cultures so called ‘Beast from the East’. represented here in our friendly, But then came the summer welcoming and informal College. when the weeks of hot sun DReading through this newsletter what becomes searing down upon us meant apparent (and possibly surprising) is that a place the that the Darwin gardens were size of Darwin has, and is having, such an impact on parched, with grass like straw. the wider world. And what is documented here is Relax, it’s green again now. only the tip of the iceberg. Darwin over its short 54- year existence has produced alumni and Fellows who have, through their research and business acumen, DarwinianTHE 2 “Reading through this newsletter what becomes apparent (and possibly surprising) is that a place the size of Darwin has, and is having, such an impact on the wider world.” changed the world for the better. I am thrilled to be part of it. This term began with a real highlight: we were so pleased that Darwin alumna Elizabeth Blackburn, one of our eight Nobel laureates, visited College.
  • Predicting Protein Folding Pathways Using Ensemble Modeling and Sequence Information

    Predicting Protein Folding Pathways Using Ensemble Modeling and Sequence Information

    Predicting Protein Folding Pathways Using Ensemble Modeling and Sequence Information by David Becerra McGill University School of Computer Science Montr´eal, Qu´ebec, Canada A thesis submitted to McGill University in partial fulfillment of the requirements of the degree of Doctor of Philosophy c David Becerra 2017 Dedicated to my GRANDMOM. Thanks for everything. You are such a strong woman i Acknowledgements My doctoral program has been an amazing adventure with ups and downs. The most valuable fact is that I am a different person with respect to the one who started the program five years ago. I am not better or worst, I am just different. I would like to express my gratitude to all the people who helped me during my time at McGill. This thesis contains only my name as author, but it should have the name of all the people who played an important role in the completion of this thesis (and they are a lot of people). I am certain I would have not reached the end of my thesis without the help, advises and support of all people around me. First at all, I want to thank my country Colombia. Being abroad, I learnt to value my culture, my roots and my south-american positiveness, happiness and resourcefulness. I am really proud of being Colombian and of showing to the world a bit of what our wonderful land has given to us. I would also like to thank all Colombians, because with your taxes (via Colciencia’s funding) I was able to complete this dream.
  • Giulio Fermi's Contributions to Biophysics and Molecular Biology

    Giulio Fermi's Contributions to Biophysics and Molecular Biology

    Giulio Fermi’s contributions to biophysics and molecular biology Fabio Pichierri Department of Applied Chemistry, Graduate School of Engineering, Tohoku University, Aoba-yama 6-6-07, Sendai 980-8579, Japan E-mail address: [email protected] [v.1, January 7, 2018] Abstract This paper presents a comprehensive list of the scientific articles of Giulio Fermi (1936-1997), son of the Italian-American physicist Enrico Fermi, published between 1962 and 1997. The initial research activity of Giulio was concerned with virology and biological cybernetics while, from 1975 onward, his work was completely devoted to protein crystallography. The crystallographic research was carried out in collaboration with Nobel laureate Max Perutz at the Medical Research Council (MRC) Laboratory of Molecular Biology in Cambridge (United Kingdom). A short biography of Giulio (Judd) Fermi appears inside John Finch’s book “A Nobel Fellow on Every Floor: A History of the Medical Research Council Laboratory of Molecular Biology” published by the MRC in 2008. Keywords: History of Science; Virology; Biological Cybernetics; Biocrystallography; Hemoglobin; Protein Structure; Biomolecules 1 1. Introduction Enrico Fermi (1901-1954) [1-6], the famous Italian-American physicist who displayed the rare ability of performing both experimental and theoretical research at equal levels of originality and creativity, received the Nobel Prize for Physics in 1938 "for his demonstrations of the existence of new radioactive elements produced by neutron irradiation, and for his related discovery of nuclear reactions brought about by slow neutrons" [7]. When the award ceremonies in Stockholm were over, after paying a short visit to Niels Bohr in Copenhagen, Enrico and his family fled to America on board of the RMS Franconia [3].

  • Quentin H. Gibson 1918–2011

    Quentin H. Gibson 1918–2011 A Biographical Memoir by J. Woodland Hastings and John S. Olson ©2014 National Academy of Sciences. Any opinions expressed in this memoir are those of the authors and do not necessarily reflect the views of the National Academy of Sciences. QUENTIN HOWIESON GIBSON December 9, 1918–March 16, 2011 Elected to the NAS, 1982 Quentin Gibson1 was a remarkable scientist, well known for his life-long research on the kinetics, intermediates and mechanism of oxygen, carbon monoxide and nitric oxide binding to hemoglobins. More than 200 of his 250 plus publications are concerned with hemoglobins and myoglobins, and his first paper was published while he was on the junior staff in medical school (1). Gibson’s discov- eries and conclusions about the function of hemoglobins are now textbook material for biochemistry, biophysics, and hematology classes. Photo courtesy of ASBMB. of Photo courtesy Gibson is known even more widely for his Stopped Flow mixing apparatus (2), which allows kinetic measurements of reactions within 1-2 msec after mixing. His design, By J. Woodland Hastings which resulted in more rapid and complete mixing, has and John S. Olson stood the test of time and is used in almost all modern instruments(3). He also developed flash photolysis methods in conjunction with rapid mixing, which led to additional important discoveries in heme and flavo-protein kinetics. Gibson’s signature style was to work closely at the bench himself, often with a collab- orator, of which there were an extraordinarily large number over his long career. The relationships formed during these collaborations were highly individual and intellectually intense.
  • Acknowledgment of Reviewers, 2008

    Acknowledgment of Reviewers, 2008

    Proceedings of the National Academy ofPNAS Sciences of the United States of America www.pnas.org Acknowledgment of Reviewers, 2008 The PNAS editors would like to thank all the individuals who dedicated their considerable time and expertise to the journal by serving as reviewers in 2008. Their generous contribution is deeply appreciated. A Sarah Ades Qais Al-Awqati Marwan Al-shawi Anne Andrews Stuart Aaronson Elizabeth Adkins-Regan Tom Alber Gre´goire Altan-Bonnet David Andrews Alejandro Aballay Frederick Adler Cristina Alberini Karlheinz Altendorf Tim Andrews Cory Abate-Shen Kenneth Adler Heidi Albers Sonia Altizer Timothy Andrews Abul Abbas Lynn Adler Jonathan Alberts Russ Altman Alex Andrianopoulos Antonio Abbate Ralph Adolphs Susan Alberts Eric Altschuler Jean-Michel Ane´ L. Abbott Luciano Adorini Urs Albrecht Burton Altura Phillip Anfinrud Hanna Abboud Johannes Aerts John Alcock N. R. Aluru Klaus Anger Maha Abdellatif Jeffrey Agar Kenneth Aldape Lihini Aluwihare Jacob Anglister Goncalo Abecasis Munna Agarwal Courtney Aldrich Pedro Alzari Wim Annaert Steffen Abel Sunita Agarwal Jane Aldrich David Amaral Brian Annex John Aber Aneel Aggarwal Richard Aldrich Luis Amaral Lucio Annunciato Hinrich Abken Ariel Agmon Kristina Aldridge Richard Amasino Aseem Ansari Carmela Abraham Noam Agmon Maria-Luisa Alegre Christian Amatore Kristi Anseth Edward Abraham Bernard Agranoff Nicole Alessandri-Haber Victor Ambros Eric Anslyn Aneil Agrawal R. McNeill Alexander Stanley Ambrose Kenneth Anthony Soman Abraham Anurag Agrawal Richard Alexander Indu Ambudkar
  • UNDERSTANDING DNA, Third Edition

    UNDERSTANDING DNA, Third Edition

    Prelims.qxd 13/02/2004 12:53 AM Page i The Molecule & How It Works Third Edition Prelims.qxd 13/02/2004 12:53 AM Page ii From reviews of earlier editions A systematic and comprehensive analysis of the structure of DNA from a wonderfully fresh perspective. The book is a systematic effort to under- stand this fascinating molecule from the inside out, building from the first, and simplest, principles … . I recommend it very highly. Trends in Genetics We see DNA structures so often that it is often taken for granted that the molecule should not be anything but an aesthetically appealing, spiraling helix. But why should it assume such a nice structure? The book offers an absolutely delightful answer to this and other similarly mischievous ques- tions. ‘Understanding DNA’ is a great book that will surely prove to be a valuable teaching tool. The Biochemist Among the strengths of the book are the clarity of the explanations of some quite difficult concepts and the novel way in which certain ideas are treated, perhaps causing the reader to think again about certain aspects of DNA structure. I enjoyed reading this book and would encourage col- leagues working in the general area of DNA research to read it. Heredity Stylish … beautifully crafted, with a logical step-by-step approach to the subject. A book from which the advanced undergraduate will benefit, and which will also generate a refreshing perspective for experts. Nature Authoritative and lucid. Aaron Klug Prelims.qxd 13/02/2004 12:53 AM Page iii The Molecule & How It Works Third Edition by Chris R.
  • Acknowledgment of Reviewers, 2014

    Acknowledgment of Reviewers, 2014

    Acknowledgment of Reviewers, 2014 The PNAS editors would like to thank all the individuals who dedicated their considerable time and expertise to the journal by serving as reviewers in 2014. Their generous contribution is deeply appreciated. A Joseph Adams Seungkirl Ahn Hashim Al-Hashimi Luis Amaral Kjersti Aagard-Tillery Michael Adams Tero Ahola Javey Ali Rommie Amaro Duur Aanen Paul Adams Cyrus Aidun Antonios Aliprantis Bruno Amati Jorge Abad Ralf Adams Iannis Aifantis Kari Alitalo Jayakrishna Ambati Alejandro Aballay Lee Adamson Kazuyuki Aihara Rob Alkemade Richard Ambinder Adam Abate John Adelman Judd Aiken Michael Alkire Stanley Ambrose Alireza Abbaspourrad Karen Adelman Elizabeth Ainsworth Robin Allaby Indu Ambudkar Jonathan Abbatt Zach Adelman William Aird Milan P. Allan Chris Amemiya Patrick Abbot Pia Ädelroth Edoardo Airoldi Marc Allard Jan Amend Albert Abbott Sarah Ades Joanna Aizenberg Hunt Allcott Amal Amer Allison Abbott Ilensami Adesida Michael Aizenberg Martin Allday Stefan Ameres Derek Abbott Becky Adkins Myles Akabas Andrew Allen Sebastian Amigorena Larry Abbott Elizabeth Adkins-Regan Ilke Akartuna Charles Allen Mohammed Amin Nicholas Abbott Andy Adler Erol Akcay Dale Allen Ido Amit Paul Abbyad Frederick Adler Mark Akeson David Allen Gabriel Amitai Omar Abdel-Wahab Gregory Adler Christopher Akey Eric Allen Sygal Amitay Yalchin Abdullaev Lynn Adler Ethan Akin Irving Allen Markus Ammann Ikuro Abe Roee Admon Shizuo Akira James Allen David Amodio Jun-ichi Abe Ralph Adolphs Gustav Akk John Allen Angelika Amon Koji Abe Jose Adrio Mikael Akke Karen Allen Christopher Amos Goncalo Abecasis Radoslav Adzic Serap Aksoy Melinda Allen Linda Amos Stephen Abedon Markus Aebi Anastasia Aksyuk Nicola Allen Derk Amsen Markus Abel Toni Aebischer Klaus Aktories Paul Allen Ronald Amundson Moshe Abeles G.
  • The Spetses Summer Schools

    The Spetses Summer Schools

    THE SPETSES SUMMER SCHOOLS A Tribute to Marianne Grunberg-Manago Founding and More than 40 Years of the School How Spetses Summer Schools Were Run Financing the Spetses Summer Schools Past and Future of the Spetses Summer Schools Horst Feldmann 1 THE SPETSES SUMMER SCHOOLS A Tribute to Marianne On January 4, 2013, Marianne Grunberg-Manago passed away, two days before her 92nd birthday. She survived 13 difficult years, after she had suffered a terrible brain haemorrhage in March 2000 that kept her in hospital for the rest of her life. Some details of her life and exceptionally important scientific contributions have been recognized in a recent FEBS Obituary [1] by her colleagues from the Institut de Biologie-Physicochimique in Paris. They finally state “... Marianne will always be remembered as a vibrant person with a great sense of humour.” Indeed, Marianne showed these qualifications in a further engagement of hers, namely in establishing the ‘Spetses Summer Schools’ in 1966. She became enthusiastic about the idea that young researches should be given an enduring opportunity to obtain thorough insights into the newly developing field of Molecular Biology. Thus the Spetses Summer Schools became well-known throughout the scientific community in Life Sciences, and anyone who ever attended one of these venues, will remember it enthusiastically. In 2006, the School celebrated its 40th Anniversary. It is mainly these ventures that document her restless dedication to all work she initiated for scientific welfare. Marianne was inviting me to many of her Schools and at other occasions. Her love for the island and the School culminated in her deep sorrow how to continue these annual enterprises after she had to stay in the hospital.