WINTER 2018/19

DarwinianTHE

From the ends of chromosomes to the food of the future: outstanding research by Darwinians

Nobel Laureate and Alumna Elizabeth Blackburn is interviewed by Ron Laskey Possibility of vaccine for Ebola

Sustainable food of the future

News for the Darwin College Community A Message from Mary Fowler Master

2018 has been a year of espite this year’s intemperate weather, Darwin, our students and Fellows have extremes, February and benefitted from and flourished within March saw biting cold wind our strong community of scholars. and rain for many weeks – the Students and Fellows appreciate the diversity of disciplines and cultures so called ‘Beast from the East’. represented here in our friendly, But then came the summer welcoming and informal College. when the weeks of hot sun DReading through this newsletter what becomes searing down upon us meant apparent (and possibly surprising) is that a place the that the Darwin gardens were size of Darwin has, and is having, such an impact on parched, with grass like straw. the wider world. And what is documented here is Relax, it’s green again now. only the tip of the iceberg. Darwin over its short 54- year existence has produced alumni and Fellows who have, through their research and business acumen,

DarwinianTHE 2 “Reading through this newsletter what becomes apparent (and possibly surprising) is that a place the size of Darwin has, and is having, such an impact on the wider world.”

changed the world for the better. I am thrilled to be part of it.

This term began with a real highlight: we were so pleased that Darwin alumna Elizabeth Blackburn, one of our eight Nobel laureates, visited College. Liz had a busy time here, she was inducted as an Honorary Fellow of Darwin, and met with current biological and biomedical students and post docs. Plus she was interviewed about her life and work by Emeritus Fellow Ron Laskey (see page four).

During the last twelve months I have visited alumni in New York, Washington, Christchurch, Wellington, several honorary degrees. It was a pleasure to be one Auckland, Hong Kong, Singapore and Kuala Lumpur. of the recipients, another delight to accompany the As always, meeting Darwinians is such a great similar degree given to me in Edinburgh the week pleasure, wherever the location and whatever the before. venue. Nearer to home, the refurbishment of the Old Granary We were very fortunate in being able to schedule the is almost complete and eight lucky students should Hong Kong reunion to coincide with our Vice-Master be moving in as you read this. Over the last year the Professor Martin Jones’ public Joseph Needham building has been sympathetically renovated and Memorial Lecture ‘Food Globalization in Prehistory’ in restored inside and out. Phase two is the completion Hong Kong Central Library. Martin has just retired of the new multi-purpose Bradfield Room. The shell after 6 years as Vice-Master – he was untiring in his of the building is in place and all that remains is for the support of the College and I am very grateful to him roof and interior to be finished. We anticipate that it (see page eleven). will be ready in the early spring. Around Easter next year we will invite our donors to the Grand Opening My New Zealand visit was scheduled around the Ceremony - the Alumni and Development Office will opening of a new integrated science building at the keep you posted. University of Canterbury by Prime Minister Jacinda Ardern. We gave her a Darwin College teddy bear In January there is of course, the annual Lent Term (the version wearing a dark blue sweater, that being Darwin College Lecture Series to look forward to. The closest to ‘All Black’) for her baby. The reunion in 2019 Series is entitled ‘Visions’. We have eight eclectic Wellington was particularly memorable as I flew lectures for you to share in, whether in the auditorium from Christchurch in the morning, leaving there just or watching afterwards online. The full programme is before a major cyclone caused closure of the airport, on the reverse of the newsletter, and I hope to meet and arriving in Wellington just before that airport many of you there. was also closed. Schools and businesses closed, BUT Darwinians are resilient – on that really wet and windy After the Lecture Series finishes, I plan to travel to Left: evening in an almost completely deserted Wellington Beijing and Tokyo, and along with our Development Mary with the Prime a group of Dawinians met and talked and talked... Director Samuel Venn, am looking forward to meeting Minister of New Zealand, with alumni and hearing about how Darwinians are Jacinda Ardern, who is holding Ernest Rutherford’s One of the great pleasures of the year was visiting the impacting that area of the world. Plans are embryonic Nobel Prize. University of Leeds to attend the ceremony investing at this stage, but I am excited about the trip and to Darwin Fellow, Dame Jane Francis as Chancellor of hosting events there. Above: that University. It is a much deserved honour for Jane Mary receiving her Honorary Degree from who is Director of the British Antarctic Survey and an My very best wishes for a peaceful and happy Jane Francis, University of exceptional scientist. Once installed, Jane conferred New Year. Leeds.

WINTER 3 2018/19 From Graduate Student to Honorary Fellow, Elizabeth Blackburn Nobel Laureate in Physiology or Medicine

An Interview by Ron Laskey

Elizabeth Blackburn was a Graduate Student at Darwin 1972-1975. She received the Nobel Prize in Physiology or Medicine in 2009, together with Carol Greider and Jack Szostak for their discovery of how the ends of chromosomes are protected by telomeres and the enzyme that makes them, telomerase.

Ron: Welcome back to Cambridge.

Liz: It’s good to be here.

Ron: Obviously one question that Darwin students would like to know is what was it like to be in Darwin back in the 1970s?

Liz: Well it was a good place to be because, as a PhD student, it was exactly what I wanted. A college all about the life of PhD students and I was at the stage when I didn’t want to be in an undergraduate college because I was beyond that kind of thing. Darwin was very international; it was very informal; it was friendly and it was in the right place. I enjoyed the interactions and the time that I had here because it was so much geared toward exactly the situation I was in, a PhD student who had come from Australia, immersed in the research of Cambridge and just needing another home besides the research lab.

Ron: I think you just encapsulated what appeals to many of us about Darwin.

Liz: Good! So being a student at Darwin College I had a room in the Old Granary and I remember just thinking I had died and gone to heaven, because you looked out on this mill pond, still a very beautiful, bucolic landscape. You know you’re in Cambridge and you’re looking at trees and grass and it’s extremely lovely and you just hear the ducks every morning when you wake up. To this day I can conjure Right: up this sound of those ducks down on the water. Our new Nobel Laureate discusses his work. It was a pleasant room and it seemed inordinately Photo Credit: Sir Cam large to me. I don’t know why; it wasn’t a very high

DarwinianTHE 4 room but it somehow seemed very spacious. It was Yet everybody worked really hard and there was a quite a lovely place to be. To have a room like that as culture of having long hours in the lab. Interestingly, a student, as I said I thought I had died and gone to Fred wasn’t one prone to extensive discussions heaven. as Francis Crick and Sidney Brenner were. He just liked you to get your hands on the experimental Ron: But you also had another rather special place material. I remember when I first arrived I said: “Fred, for your PhD, the MRC Laboratory of Molecular well I suppose I should be doing a lot of reading” Biology, the LMB. How did that feel? and he said, “Well I’ll show you how to use this little capillary and you can pick little spots out to solubilise Liz: Yes, I think the LMB was all about research and oligonucleotides”. So, he just dived right into the that thrilled me because I had learned that was what experimental material and I related very well to that. I really loved to do. I was in the research group of Fred Sanger and Fred had a very informal way of Ron: After you left the LMB you went to work with encouraging you to be hands on very quickly and someone else who has a very special reputation as a then to let you find your way. I felt at home very mentor and as a superb scientist, namely Joe Gall. quickly. I had found two places where I could feel comfortable as a student. Liz: Yes, this was Joe Gall at Yale and he became known because several of his women trainees had Ron: How does it feel to look back to those times done very well scientifically in academic research. now when your project was to determine a very This was an influence in my applying to work small part of the DNA sequence of a small bacterial with him. I had heard that he was not only a good virus, whereas now whole large genomes can be scientist, but he was also a good person to work churned out in a very short time? with. And Joe again let me really develop as a scientist by just running with the problem of trying Liz: Well you know it’s laughable how embryonic to understand DNA sequences at the ends of very this was, but it was opening up a way of thinking small chromosomes in the model system that I was about the genome. You had a feeling that you were using, a single celled organism called Tetrahymena. on a new frontier. Already the idea that you could ask a question in different ways, because suddenly you Ron: Your choice of Tetrahymena ribosomal DNA, had new information that nobody had ever had, was where there are additional linear copies with ends on incredibly heady. I hope that that’s what scientists the molecules that you can study was profoundly…. feel now as they have new ways of dealing with hitherto inaccessible knowledge and information. Liz: Lucky!

Ron: Just the fact that any sequence information Ron: I wouldn’t have said lucky; I would have said a could be derived from DNA at that time must itself very good choice. have been exciting. Liz: Joe Gall had been fascinated by genes that Liz: Yes, and it was intellectually pleasing because get into higher copy numbers, amplified as it is I remember the day when there was someone called. Using electron microscopy, he had recently deriving amino acid sequences of a protein very found that the amplified ribosomal RNA genes in directly, others in Fred’s group, including my (future) Tetrahymena were linear molecules, uniform in size husband, looking at the DNA sequence and I was and present in about 10,000 copies of these per copying DNA into RNA because there were well single cell. So, you know that’s as good as virus in established ways of getting sequences pieced terms of a very high copy number. together with RNA. When the three lined up it was like: the central dogma works: phew! Ron: At what stage did you choose telomeres, the ends of the chromosomes, as your target? Ron: And what was Fred Sanger like to work with? Liz: I chose them because this was before DNA Liz: Well Fred was really the perfect advisor for my cloning had begun and I thought how do you get a temperament. It helped that all his group were sequence of something? Either you chop it in little exploring various ways of getting DNA sequences pieces and purify it, and that’s what was done for and that he was doing it himself in the way that the bacteriophage genomes, or you cleverly started became the Sanger sequencing method. The in one place, but where were the landmarks in the atmosphere was to just ask anybody anything, ribosomal RNA genes? The only places you could including Fred. And if I had a gel that looked peculiar approach were the ends, and from day one it was like: I would show it to Fred and ask what did he think. “Wow! something very different is going on there. This Opposite: It was a remarkably un-hierarchical culture, which I is not what virus ends look like”. So that was great fun Elizabeth Blackburn. think from my colonial view point I appreciated a lot. because it was immediately interesting. Photo credit: Sir Cam

WINTER 5 2018/19 Above: Ron Laskey and Elizabeth Blackburn. Photo credit: Sir Cam

Ron: What was the clue, that told you that this is University of California San Francisco, at an up and fundamentally different, that there is a specialised coming department of biochemistry, and I applied structure at the ends of the chromosomes? for a job at Berkeley but they just said we’re on hold. Then they opened up the search again because Liz: There were two things. People were just they got funding and I got the job, so I started in the beginning to use restriction enzymes to cut DNA middle of ’78 at the University of California, Berkeley, into small enough pieces for me to say that all the having been 6 months at the University of California, molecules in the population were identical inside, San Francisco. So, in some ways the system was more but the ones at the end had a blurry look to them. forgiving, but in other ways we definitely had to.... In other words, the population of molecules have different lengths at the end. The second was when Ron: Make sacrifices.... I started radioactively labelling these molecules, asking enzymes to copy the DNA at the ends and see Liz: Well I didn’t think of it as making sacrifices but what sequences became labelled up. Immediately it wasn’t as if it fell into our laps. We had a lot of the signals for seeing the fragments that you could rejection letters so it wasn’t like we could just get the put together were irrationally strong and that said first job we wanted. that there had to be repeated DNA sequences out there and it was quite a job working that out, so I Ron: And at which point did you discover spent my postdoc piecing these together. telomerase, the enzyme that makes the ends of chromosomes? Ron: At what point in the story did you move to California? Liz: That was all at Berkeley. In the early 1980s I started to suspect that there might be an enzymatic Liz: After I’d finished my postdoc, a paper was sent in activity so thought go for Tetrahymena because it about finding this repeated sequence at the ends of has a lot of telomeres and I grew vats and vats of these little tiny chromosomes. And then I just had to Tetrahymena. I had learned that from Joe Gall who’d job hunt, and my (by then) husband John Sedat and always said: “If you have a biological question the I put ourselves on the job market. Everyone thinks principles may be general, but find a system where it’s very easy, but I have a pile of rejection letters it’s experimentally amenable”. I really learned that somewhere. Then John was offered a job at the from that postdoctoral experience.

DarwinianTHE 6 Ron: The discovery that telomerase had an RNA from the model system. The yeast and telomerase template component must have been immensely work was done in the 80s. Work on telomeres and exciting. I remember it was exciting to people that telomerase in yeast and Tetrahymena was going back weren’t working on it, so what must it have been like and forth between the systems in the 80s so that’s for you? a few decades. The interest in humans started to emerge from a lot of different converging and not Liz: Yes, well most people thought it was weird so converging interests. People started looking for in Tetrahymena and they could ignore it, so that telomerase enzymatic activity and we had a good was good for us because we could just do it. First, assay system for it. It wasn’t lost on people that there was an enzymatic activity that was making a cancer cells keep replicating and so quite quickly DNA sequence, not a very long one, a repeat of 6 people started finding enzymatic activity in cancer nucleotides but still putting them in sequence. So, cell extracts and then it was realised that of course Carol (Greider) and I worked very much with “Oh my normal cells actually do have to maintain ends God, what about this artefact?” and “Oh my God, this to some degree. It turned out that in humans it’s could all be just something uninteresting”. Then we enormously nuanced and specific for tissue type and would try and think of an experiment, so gradually developmental stage. we homed in on “It’s going to be hard to explain this one away”. Ron: Did you have any suspicion that it was going to turn out like that at the time? Ron: And that was the time at which you got the gel with this spectacular ladder of bands… Liz: None at all! I mean the only thing was that when we knocked out telomerase activity by making a Liz: That was an early result that said there was rather surgical mutation in the RNA, by accident of something you could get your hands on now. Before, course, in Tetrahymena, we did see something that I’d seen some products getting a little bit longer and we said we’re going to call ‘senescence’ because it at very low resolution but once they were run on a was clear that there was not an instant problem and DNA sequencing gel that then spread it out. So, it then cells progressed for a while and the telomeres worked well that you could get high resolution and got shorter, but that was in a model system and visualise it. When Carol saw this she realised, and there was nothing that linearly extrapolated into showed me next day and I realised, this is good. whole mammals. It’s great fun when fields are growing and you are just in very exciting stages of Ron: And you then did a beautiful series of never knowing …. experiments in which you showed that changing the sequence of the template changed the sequence of Ron: You must have had a certain amount of the telomeres, which was a clincher. satisfaction from the knowledge that you actually started the field. Liz: Yes, well I’d done this with Jack Szostak in a lovely experiment where we did this crazy thing. We Liz: Well I was too busy to have satisfaction. You’re said if we put a Tetrahymena telomere onto the end immersed and you don’t really think about that, so of a linear plasmid in yeast would that now stabilise I was just constantly doing science and then later that linear plasmid in yeast. When we did this, we when people started giving awards I thought: “Yes, said: “Well let’s see what’s added on to the ends” this is great to have been able to do something and the ends got longer and it was yeast telomeric where you learn something”. Then lots of work done repeats. First, Carol and I thought a lovely reciprocal by many others has expanded it into different kinds would be to give a yeast primer to Tetrahymena and of questions but we certainly didn’t initially think: that pleased us a lot and convinced us that this was “How will this play out in humans?” We just really a biologically real enzyme. Then, my student Guo- didn’t know. Liang Yu actually changed the template itself in the RNA and that proved telomerase really copied it into Ron: Thank you so much for coming back and DNA. talking to us and congratulations on becoming an Honorary Fellow of your old College, Darwin. Ron: So how long was it after you found telomeres and telomerase that you received the information that you were being awarded the Nobel Prize in Physiology or Medicine?

Liz: That was October 2009 and I suppose the very first sequence of Tetrahymena, which certainly didn’t look very physiology or medicine related, was 1978 and then we published telomerase but, first of all,

WINTER 7 2018/19 From the Development and Alumni Relations Office

“Darwin College is one of the most welcoming places to be a student. I have found nothing but friendliness and helpfulness since I arrived.”

his comment is from a new student to Derek our Head Porter. It echoes what we are trying to achieve in the Development and Alumni Relations Office: we aim to emulate the community feeling within College to our wider alumni body. We always welcome your Tcomments and try to act on them wherever we can. This year we have held events not only in Cambridge, but also in New Zealand, London, Hong Kong, Kuala Lumpur and Singapore. Our Development Director Samuel Venn will be in New York in December and hopes to see many alumni at a dinner he will host.

Events for 2019 are beginning to take shape, and it looks to be an exciting year, with dinners in Beijing, Shanghai, Tokyo and Athens already in the diary. 2019 is also the Thank you to everyone who has donated in the past Darwin College Boat Club’s 50th Anniversary and they are year. Here is where you asked for your gifts to be planning an extravaganza of celebrations on July 6 2019. allocated and the money received to date: All alumni are very welcome to attend, and we hope to see many of you there! Gifts by fund July 2017–June 2018 Bradfield Court £44,606 Building and Grounds £35,966 Of course, an important part of the remit of the David McKay Fellowship £744 Development Office is fundraising. This year we have Lecture Series £10,737 focussed on two areas. Patrick Sissons Fellowship £10,017 Philosophy Fund £2,332 The first is to raise money to increase the amount of Student Support and Studentships £62,171 funds available to students facing hardship due to Where most needed £149,483 unexpected emergencies. I am pleased to report that in 2016-2018 51 students received emergency Thanks to a legacy gift from a US alumna, we have funding of between £25 and £2,000, and next year, put one studentship in place this year. The College with your help we should be able to help more students is happy to announce that for 2019-20 entry Darwin in adverse circumstances. is offering a new David Ellar/BBSRC Scholarship. The scholarship is named in honour of the legator’s The second area is Studentships, funding has become PhD supervisor and has been match funded by the increasingly scarcer for graduate students, and many Biotechnology and Biological Sciences Council. It will Darwin students spend much of their time applying for cover the cost of the University tuition fees and an funds and getting nowhere. We are therefore working annual maintenance stipend for four years. We are towards providing scholarships for students to study grateful to her forward planning and her memory at Darwin by increasing the number we have available will be honoured through this scholarship for years to to those who cannot afford to fund their graduate come. studies. The brightest students should have the opportunity to study at Cambridge, not limited by You may well have noticed that the GDPR (General their ability to pay. Data Protection Regulations) came into force

DarwinianTHE 8 Patrick Sissons Fellows

Below The Master with alumni at the Reunion Dinner in Hong Kong Following donations received from alumni and friends of Darwin, as well as the Evelyn Trust’s generous commitment to funding three years of a Research Fellowship in honour of Professor Sir Patrick Sissons, we elected Dr Iosifina Foskolou as Patrick Sissons Evelyn Trust Research Fellow. Iosifina joined Darwin in October 2018, and is working on the role of low-oxygen (hypoxia) inducible metabolites in cancer immunology. She undertook her DPhil studies at the Department of Oncology at Oxford University, where she investigated the DNA replication stress induced by hypoxia and was funded by a CRUK in May. GDPR is a regulation that covers privacy Oxford Centre DPhil Prize Studentship. To ensure for all individuals within the European Union and that Patrick's name continues to be associated with the European Economic Area. It also addresses the research in medicine (particularly immunology), we export of personal data outside the EU and EEA areas. are seeking further donations to fund the Research Primarily its aims are to give control to individuals Fellowship, either by annual funding after the initial over their personal data and to simplify the regulatory three years, or by finding the endowment capital sum. environment for businesses by unifying the regulation within the EU. Funding received by the Clinical School in Darwin College has a Data Protection Statement Cambridge has enabled specifically for our alumni and supporters which outlines Darwin to appoint a our policy on how we look after your data. You can find Professorial Fellow, it by going to: darwin.cam.ac.uk/alumni/data-protection. who will also be known as a Sissons Fellow: Finally, if you are visiting Cambridge, please do call into Professor James Darwin: alumni are always welcome to visit the College! Rowe. James is a neuroscientist and a cognitive You can come in for cafeteria meals and pay with a neurologist, and leads a major research programme normal bank card, and you can book into formal dinners, into Parkinson’s-plus diseases in Cambridge. He and reserve College punts, by contacting the Alumni became Professor of Cognitive Neurology at the Office. University of Cambridge in 2015, and he is also an affiliated Professor of Clinical Neuroscience at the University of Copenhagen in Denmark. He is The Development and Alumni Relations Team an active consultant neurologist, leading regional consists of: specialist clinics for patients with early dementia, Samuel Venn, Development Director frontotemporal dementia, Progressive Supranuclear [email protected] Palsy, and other ‘tauopathies’. Sophia Smith, Deputy Development Director [email protected] Eleanor Collingwood, Alumni Officer [email protected]

WINTER 9 2018/19 News from the Fellows

Two new University Chancellors Two New Honorary Fellows for Darwin

Honorary Fellow and Darwin alumna Professor Dame Jean This year, Professor Elizabeth Blackburn and Professor Eric Thomas was invested as Chancellor of Swansea University in Maskin, both Nobel Prize winners and both with Honorary January. She succeeds former first minister of Wales, Rhodri Morgan, Doctorates from Cambridge University, were elected as Honorary who was chancellor from 2011 until his death in 2017. She said it Fellows of the College. Elizabeth is an alumna of the College, having was an honour to serve the University she graduated from “many graduated with a PhD in Biology in 1975. A full interview with her years ago”. She is looking forward to being part of the University’s about her research and its consequences on longevity is on page “exciting ambition” in the run up to its centenary year in 2020. four of this newsletter.

Eric Maskin carried out research in Cambridge while a visiting student from Harvard in 1975-6. He was resident at Darwin during that time, and remembers fondly his time in the Old Granary. “For whatever reason – the dazzling first impression Cambridge made on me, the colourful and eccentric characters I encountered, or perhaps just because I was young – that initial Cambridge sojourn has the rosiest glow of all in my memory.”

Nobel Prize Win College Fellow Professor Dame Jane Francis was invested as Chancellor of Leeds University in June. She succeeds Melvin Bragg. She has strong ties with the University, with a 22-year career at Leeds before joining the British Antarctic Survey, where she has been Director since 2013. Jane said: “I loved my time at Leeds and feel truly honoured to be back as Chancellor. Helping to inspire passion and achievement is what excites me in my work, and in this role I hope to be able to do just that.”

We are pleased to announce that Professor Sir Gregory Winter, Master of Trinity College and Honorary Fellow of Darwin College, was jointly awarded this year’s Nobel Prize for Chemistry. Shared with Frances Arnold and George Smith, the prize was awarded for their work in harnessing evolution to produce new enzymes and antibodies; their work has led to the development of new fuels and pharmaceuticals by making use of nature’s evolutionary processes Following Jane Francis’s investiture, she had the pleasure of themselves, leading to medical and environmental advances. giving Professor Mary Fowler, Master of Darwin College, an Honorary Doctorate of Science for her contribution to the study of This win means that Darwin now has a tally of eight Nobel Geophysics. Mary had been similarly honoured with an Honorary Laureates, which is a remarkable achievement for a College which Doctorate in Science from the University of Edinburgh (pictured) is only 54 years old. just a few days previously. Above, left to right: Alan Fersht, Gregory Winter, Mary Fowler and Christopher Dobson.

DarwinianTHE 10 Retirement of Martin Jones, a much-loved Dr Jan Löwe appointed Director of the Vice-Master Laboratory of Molecular Biology

Professor Martin Jones has retired as College Vice-Master. He was elected a Fellow of Darwin in 2002 and became Vice- Master in 2012. Martin was until retirement the George Pitt-Rivers Professor of Archaeological Science, and is particularly interested in the archaeology of food. His work focused on the spread of farming across Asia, food sharing in the Upper Palaeolithic and the development of agrarian societies and their food economies in Darwin Fellow, Dr Jan Löwe, was appointed as Director of the later prehistory and historic periods. MRC Laboratory of Molecular Biology (LMB) earlier this year. Jan became a Fellow of Darwin College in 2012, and was previously the In July of this year, Martin was elected as a Fellow of the British joint head of the Structural Studies Division at the LMB, and Deputy Academy in recognition of his work in the field of archaeobotany. Director of the Institute.

On his retirement his colleagues at the Founded in 1962, the LMB is a multi-disciplinary research institute Department of Archaeology looked for dedicated to the understanding of important biological processes something appropriate to present to him. at the levels of atoms, molecules, cells and organisms, towards The answer was a limited edition beer named solving key problems in human health. Scientists at the LMB tackle in his honour! This collaborative beer was difficult long-term research problems and have made revolutionary brewed with Professor Jones and some of contributions to science – such as in the sequencing of DNA and his colleagues, at Milton Brewery, and was pioneering the method of X-ray crystallography to determine launched at the Cambridge Beer Festival protein structure. in May. It is named after the Roman festival Cerealia – in honour of the goddess of agriculture and fertility. Jan said on his appointment: “Not in my wildest dreams would I have thought in 1996 when I came here that I would one day be the director He is now an Emeritus Fellow of Darwin, and we wish him all the of this great institute. Being given such an important job makes me best in his retirement. feel both excited and humbled. I will aim to preserve and develop LMB’s very special culture and people, so that new ideas keep the LMB at the forefront of molecular biology, where it belongs.”

Richard Henderson appointed Companion Darwin College has had a long and distinguished list of Fellows, of Honour Honorary Fellows, and alumni who have been associated with the LMB, including four Nobel Laureates: Max Perutz, Richard Nobel Laureate and Emeritus Fellow of Darwin Professor Richard Henderson, César Milstein, and Elizabeth Blackburn. Henderson was appointed a Companion of Honour in the Queen’s Birthday Honours 2018. Distinguished Associate Jill Kerr Conway

Ron Laskey awarded an Honorary The College is sad to report the passing of Australian-American scholar and author Jill Kerr Conway, who died in June 2018. Doctorate Well known for her autobiographies, in particular her first memoir The Road from Coorain, she was also Smith College’s first woman In early October Emeritus Fellow Professor Ron Laskey was president and most recently served as a visiting professor at the awarded an Honoris Causa Doctorate from Montpellier University Massachusetts Institute of Technology. in France.

WINTER 11 2018/19 People

Zoonotics: viruses crossing species

Professor Jonathan Heeney is a Fellow of Darwin College and has recently taken up the position of joint Vice-Master following the retirement of Martin Jones. Jonathan established The Lab of Viral Zoonotics (LVZ) in the Department of Veterinary Medicine at Cambridge. He and his team are developing an all-in-one vaccine for some of the deadliest viruses known – Ebola, Lassa and Murburg viruses.

how to contain ‘surprise’ occurrences and prevent potentially devastating global pandemics.

In recent Ebola outbreaks WHO (The World Health Organisation) has tried to contain the epidemic by ‘ring vaccination’ – a methodology developed by veterinarians to contain epidemic outbreaks in livestock. Medics are now using this practice to vaccinate a ring of people at risk around each infected individual. However, this response can only be used after an outbreak, such as the ongoing Ebola outbreak in the Democratic Republic of Congo. In order to prevent future outbreaks, it is vital to understand and predict which strain of virus are most likely to cause them.

“A disproportionally high number of emerging and re-emerging diseases – from Ebola to Lassa through to rabies and influenza – are caused by RNA viruses carried naturally by animals,” says Jonathan. “We Above: ‘Zoonotics’ is defined as the transference of an know very little about the viral diversity within these Jonathan Heeney has infection from animals to humans. Unfortunately, reservoir species and what enables them to spread founded DIOSynVax Ltd, a new Cambridge start-up there have been many high profile examples of to humans – and hence where the likely future to make a new generation such outbreaks in the last thirty years – HIV, avian threats lie.” of vaccines to prevent flu, swine flu and more recently Ebola, Lassa and epidemics like Ebola in the Marburg viruses. All have high mortality rates. developing world. The Lab of Viral Zoonotics are taking a two pronged Outbreaks cause devastating local epidemics in the approach to fight these deadly diseases: they are human population and to wildlife. They also have the researching how to predict what strain of viruses potential to create havoc to the infrastructure and have the greatest likelihood to jump species into economies of the epidemic area. humans, and as a result hope to develop potential vaccines. Jonathan and his team of dedicated scientists take particular interest in retroviruses. Once a retrovirus Jonathan has received £1.4 million from the BBSRC has infected a cell, its RNA genome is replicated, or (Biotechnology and Biological Sciences Research ‘reverse transcribed’, into DNA and is copied every Council) to do exactly this. The One Health project time the infected cell divides. Often this happens is cross-disciplinary with veterinarians, clinicians, slowly and can sometimes go unnoticed for many ecologists, medical and public health workers in years. This ‘silent’ disease can often take the medical West Africa working to understand how Lassa community by surprise with the scale of the fever becomes transmitted from indigenous rat infection locally, and subsequently causes worries populations to humans. about a global outbreak. The team have already developed and successfully Ebola, Lassa and Marburg are RNA viruses without a tested a vaccine in guinea pigs that protects against DNA intermediate, and each of these diseases have Ebola, Lassa and Marburg viruses. As a consequence, raised concerns amongst health professionals about Jonathan has been awarded a further £2 million by

DarwinianTHE 12 “We’ve taken fundamental science that stretches back almost two decades and developed a new approach to vaccine development.”

Innovate UK and the Department of Health and Social Care to take the vaccine to clinical trials in humans.

A virus’s genetic code is written into its nucleic acid (either RNA or DNA), which leads to the code for the generation of proteins. When we are infected by a virus our immune system responds to these proteins, known as ‘antigens’, producing antibodies that can identify and try to eliminate the invading pathogen.

Jonathan has started a Cambridge spin-out company called DIOSynVax to make a new generation of vaccines. Their approach involves understanding how the immune system correctly identifies the virus from its proteins, and uses this information to create ‘virus- like proteins’ that can generate an immune response. Using copies of antibodies taken from survivors – they can then test whether the body can effectively eliminate these fake viruses, leading to protection.

“We’ve taken fundamental science that stretches back almost two decades and developed a new approach to vaccine development. This has the potential to dramatically reduce the time needed to produce new vaccines and change the way in which the industry makes them.”

With the new funding the DIOSynVax team will scale up production. They will then carry out toxicity tests in animals and human blood samples to ensure the vaccines are safe; if successful, they will trial the vaccine in healthy human volunteers. Above, top to bottom: Jonathan Heeney and the Lassa Fever field team based at the African “Equipped with this information, we should be able to Centre of Excellence for Genomics of Infectious Diseases based in Ede design Next Generation of vaccines for more effective Nigeria. and broad-protection from infections. Combined Members of the Lab of Viral Zoonotics (LVZ), Dept of Veterinary with our accelerated vaccine development platform, Medicine, in the Richard King Room. this has the potential to have an enormous positive impact on global public health.” The hypothesis that the Ebola virus may be carried in sequestered body tissues in some Human Ebola survivors, triggering new cases after the primary outbreaks are contained. Later proven to be the source of Article adapted and reproduced with the permission of post-outbreak flare-ups of human cases. (J Heeney, Nature. 2015 Nov Cambridge University. 26;527(7579), image courtesy of Nature)

WINTER 13 2018/19 People

Sustainable Fish and Poultry Food of the Future...

Insect protein could be used to feed fish and poultry after a Cambridge company co-founded by Darwin alumnus Matt McLaren (MBA 2014) was awarded a £900,000 government grant in 2017 to further its work.

he company comprises four recent Cambridge University graduates with backgrounds in biochemistry, biology, engineering and business, and has been supported by the Cambridge Judge Entrepreneurship Centre’s ‘Accelerate Cambridge’ Tprogramme. “It’s one of those stories where we came together in a pub over a pint, talking about weird ideas,” explains Matt. “The team has members from the Department of Biochemistry, from Engineering, from the Business School, so it really is a diverse skill set.”

Entomics Biosystems works with the University of Stirling and the University of Reading to investigate the effectiveness of insect-derived feeds for farmed salmon. They conduct industrial research with the aim of reducing the reliance on resource intensive proteins such as fishmeal and soy, while also mitigating the use of antibiotics in the food chain, one of the causes of the increase in drug-resistant bacteria.

It has been estimated that each year over 1.3 billion tonnes of food are wasted globally – equating to around US$1 trillion of lost value. With an increasing population and modern lifestyles, the burden of food waste on society and the environment is set to increase in the future.

DarwinianTHE 14 “The world’s looking for more sustainable sources of feed and I think increasingly there’s a recognition that it’s not just about basic nutrition, but it’s about overall health.”

Entomics focuses on ‘insect biomass conversion’. Larvae of the black soldier fly chew their way through several tonnes of food waste collected from local supermarkets and food processing plants. The insects are fed different ‘recipes’ under controlled conditions to see how these affect growth rates and nutritional profiles. They metabolise the food waste into fats and proteins, growing to around 5,000 times their body weight within just a couple of weeks.

As McLaren, explains, these fats and proteins “are great sources of nutrition for salmon and poultry – in fact, insects are part of their natural diet. Farmed salmon in Scotland are currently fed on fishmeal which comes from wild-caught anchovies from as far away as Chile and Peru, which are then shipped across the world to Scotland,” he explains. “Insects provide a local, sustainable solution.”

With support, including from Innovate UK and the European Institute of Technology, Entomics is using a novel bioprocessing technique to boost the nutritional and functional benefits of these insect-derived feeds, using a microbial fermentation technology they have termed ‘Metamorphosis’. Essentially, these specialised feeds represent a “The world’s looking for more sustainable sources Opposite: sustainable, holistic approach to improving overall of feed and I think increasingly there’s a recognition Matt McLaren (MBA fish health and welfare. 2014) that it’s not just about basic nutrition, but it’s Above: about overall health,” says McLaren. “We are taking Salmon trials “There are several benefits to this process,” explains a promising, sustainable ingredient of the future Matt and his team at Miha Pipan, Chief Scientific Officer and fellow co- – these insect-derived feeds – and adding a bit of Entomics founder, “from affecting the gut’s microbiome and biotechnology to really enhance what the effect trying to preserve a healthier bacterial community is in the salmon and reduce reliance on traditional there, to training immune systems to make livestock antibiotics and veterinary medicines.” more resistant to disease challenges and at the same time reduce the need for veterinary medicines, Article adapted and reproduced with the permission antibiotics and vaccines.” of Cambridge University.

WINTER 15 2018/19 People

Tidings of Joy – an ongoing conservation story

Pei Rong Cheo studied at Darwin for an MPhil in Conservation Leadership in 2017, and is now working as a conservationist leading an army of volunteers to preserve the hidden treasures of Singapore's shoreline.

onservation is not just about the plants and animals. It is about people too. People may cause harm, and yet they are the very ones with hopes and “C solutions.” Inspired by fellow Cambridge graduate Sir David Attenborough, Pei Rong set up a citizen science programme, ‘Intertidal Watch’, to train volunteers and national park managers to monitor marine life, raise awareness of Singapore’s natural heritage, and promote conservation and sustainability.

“I’m a big fan of Sir David Attenborough,” she says. “I was really motivated by a quote of his. He said; No one will protect what they don’t care about, and no one will care about what they have never Pei Rong gave a talk about how she established experienced.” Intertidal Watch in 2016, as part of the Community in Nature Initiative at the National Parks Board, “I always feel that people might become a bit Singapore (NParks). The project has grown rapidly, detached from the sea, because they can’t see what’s and now has more than 250 volunteers. in our murky waters especially if they can’t swim or scuba dive, so I wanted to set up a programme that “Monitoring can be really labour intensive and would give people the opportunity to be engaged expensive, so we thought it was a good chance to with marine life.” kill a few birds with one stone. We collect data, we engage the public, and we can use the information “Singapore is located within a biodiversity hotspot. the volunteers have gathered to inform decisions, There are lots of exciting marine animals out there, management actions and even, in the future, policy.” you just need to know when and where to look.” In the early stages of the project, Pei Rong was joined During her time in Cambridge she helped to by park managers on the beach, sometimes as early establish the Cambridge University Marine as 3am. “I am very grateful for their support, and I Conservation Society and organised Cambridge’s first think this helped me to get more volunteers, both World Oceans Day event, at the David Attenborough from my organisation and the wider public.” Building, home to the Cambridge Conservation Initiative. At the event in June 2018, researchers, Once the volunteers have signed up Pei Rong gives students and representatives of non-governmental them a crash course in Singapore's marine life, so organisations and government departments they know what they can expect to find, how to delivered a series of talks about marine life, the identify and monitor the different species, and the importance of protecting it, and their ongoing importance of accurate data recording. She also efforts to do so. plans intertidal survey trips to coincide with spring

DarwinianTHE 16 “Singapore is located within a biodiversity hotspot. There are lots of exciting marine animals out there, you just need to know when and where to look.” low tides, when the seagrass beds are exposed for important that we know what is in these areas, long enough to complete a survey. At each session, so that when an accident happens or if there are the team usually have about two hours to complete development plans, activities, or events, we are their work before the tide returns, and sometimes are equipped with the information to conserve these hard at work as early as 5.30am. areas.”

“The volunteers work really hard, and they’re Pei Rong aspires to engage more volunteers and meticulous when they record things. It’s not nurture volunteer champions who can lead the field always smooth sailing, it can get very muddy and surveys. She is also in discussion with collaborators sometimes areas become flooded, but this is part of from the local polytechnics and universities on fieldwork and scientific research.” incorporating Intertidal Watch within their curricula and activities, and publishing the data collected by Pei Rong has recently returned to her position as the citizen scientists. Manager (Biodiversity) of the National Biodiversity Centre at the National Parks Board, Singapore. She Pei Rong’s experience in Cambridge has given hopes to see a protocol in place at each of the key her new ideas and broadened her perspectives in intertidal sites and integrate the monitoring process conservation. She is excited about the possibilities into the parks’ management plans. to work on different conservation initiatives in the future, including building partnerships engaging “Monitoring only works if it is long-term,” she says. communities and strengthening science-policy “Moreover, intertidal areas are often the first areas interface. affected by coastal development, so it’s really

Opposite: Pei Rong Cheo (MPhil Conservation Leadership, 2017) talking with Sir David Attenborough Left: Volunteers collecting data

WINTER 17 2018/19 People

Two birds of a feather

Darwin College is forging a new partnership with the Zukunftskolleg of the University of Konstanz in Germany. The first joint initiative in this partnership will be the Research Visit programme. Participating Fellows will not only benefit from institutional support, but also and especially from their integration into an interdisciplinary community.

hen he arrived at Darwin College in International relations are essential for realising 1989, Giovanni Galizia did not realise this aim. “International connections are crucially that his stay in Cambridge would affect important for researchers. This is why we create more than just his scientific career. He networks for our Fellows to meet with researchers had just completed his undergraduate from all over the world,” explains Giovanni. In order Wuniversity studies at the Freie Universität Berlin and to expand these opportunities for interaction, was beginning his PhD studies in Zoology. The the Zukunftskolleg initiated the Research Visits Anglo-American university system with its colleges programme. was completely new to him. But the fact that Darwin College was then, as it is today, comprised of a The programme supports international exchange community of researchers from all different kinds and collaboration in two ways: Fellows from the of scientific disciplines delighted him from the very Zukunftskolleg can visit an international institute beginning. Beyond his academic activities, he also of their choice, and early career researchers from played his part in the colleges’ theatre group, joined partner institutions can visit the Zukunftskolleg. the DCBC, became president of DCSA, and learned how to pour a headless beer at the College bar. Darwin is one of the first partner institutions with Today, Giovanni is Professor of Neurobiology and whom the Zukunftskolleg is carrying out the Director of the Zukunftskolleg at the University of Research Visit programme. “Darwin is an international Konstanz. and interdisciplinary community – just like the Zukunftskolleg. They are two birds of a feather,” The Zukunftskolleg is an Institute of Advanced Study says Giovanni when describing the basis of the that promotes the academic life of early career partnership. researchers from a multitude of disciplines. Post- Beyond the practical benefits of the Research Visit doctoral researchers and early career research group programme, participants will also benefit from leaders join for a period of either two or five years. personal interaction. “Building relationships is The Fellows are joined by established researchers absolutely essential”. Indeed, he is still in contact – the Senior Fellows – as well as doctoral students with former fellows with whom he was happy to – the Doctoral Fellows. The overall aim of the share his Darwin College experience as an early Zukunftskolleg is to provide Fellows with the tools career researcher. they need to advance both their research and their academic careers in an optimal way. Above: Giovanni Galizia (PhD Zoology, 1989)

DarwinianTHE 18 Boat Club

ith a strong progression over the last year, DCBC is now one of the most successful graduate rowing clubs in Cambridge. And the 2017/18 year saw some pretty incredible achievements! WThe first W3 in May Bumps in 17 years, an overbump by Darwin M1 in day one of Lent Bumps, decisively breaking the spell of spoons, a crew trip to Prague and a beautifully solid performance from W1 all year. But racing success aside, what has made this year so wonderful is the brilliantly positive attitude of all the crews, celebrating the victories and disappointments alike and laughing our way through it all.

Lent Bumps brought with it some spectacular bad weather featuring blizzards, hail and -8 degrees, leading to many races being cancelled. However, after an incredible effort from all of the Colleges de-icing Above, clockwise from top left: the towpath, the final days of Bumps could go ahead. Lent Bumps 2018. W1’s dramatic hand break turn in Grassy corner to secure their third and final bump. Congratulations to the crew and their coach who were awarded discretionary blades for All three of our crews managed to race three times their impressive achievements! with M1 going up 2 places, W1 going up 3 places and May Bumps 2018. Darwin M1 soaking up the sun and the applause on the final day of May W2 going down 3 places. Bumps 2018! Darwin W1 celebrated in style and cracked out the on board cocktails! Following on swiftly from their success in Bumps, W1 went straight off to race on the Thames in the Women’s Eights Head of the River Race (WEHORR). Following a short post-Bumps break DCBC started They smashed expectations by moving up an preparing themselves for racing in South Korea! Our incredible 81 positions to 149th (out of 320). crew did amazingly well at the the 2018 DGIST World Class University Rowing Festival, bringing home gold May Bumps this year was one of the most successful in the women’s coxed 4 1K race and the erg relay, as for Darwin in many years. All five Darwin crews well as silver in the mixed 8s 1K race. successfully made it through the four days of Bumps without too many crashes. W1, M1 and W2 We are very excited about this academic year, as demonstrated grand rowing abilities, bumping up our Club turns 50! Mark your calendars for the 3 out of 4 days each. Sadly, M2 didn’t have much 6th of July 2019 because we are throwing the luck but, with their row over on day 2, they avoided spoons! W3 put in a solid performance going down best anniversary party Darwin College has ever only one position overall. Most importantly though, seen. There will be racing, but there also will we all celebrated in style at a spectacular Boat Club be eating, drinking and dancing. On top of that Dinner featuring a new Darwin “shot blade” followed rumour has it DCBC is getting a new men’s boat by a trip to Wetherspoons. in 2019!

WINTER 19 2018/19 Darwin College Register 2018

VISITOR Christopher Michael BISHOP, PhD FRS FRSE; (1998); Aylwyn Olav SCALLY, PhD; (2016); Group Leader, The Right Honourable Lord BURNETT of MALDON Director, Microsoft Research Cambridge Department of Genetics (Ian Duncan), Lord Chief Justice of England and Torsten KRUDE, PhD; (2000); University Senior Julia DAVIES, PhD; (2016); Head of Transport Wales Lecturer, Department of Zoology Group, Department of Plant Sciences John Harold NILSSON-WRIGHT, PhD; (2001); Daniel Haskell WEISS, PhD; (2017); Polonsky- MASTER University Senior Lecturer, Faculty of Asian and Coexist Lecturer in Jewish Studies, Faculty of Christine Mary Rutherford FOWLER, MA PhD FRAS Middle Eastern Studies Divinity FGS FRCGS; (2012) Alan Frank BLACKWELL, PhD; (2001); Professor of Alexandra BRINTRUP, PhD; (2017); University Interdisciplinary Design, Computer Laboratory Lecturer in Digital Manufacturing, Institute of VICE-MASTERS Emily Fleur SHUCKBURGH, OBE PhD; (2001); Head Manufacturing Jonathan Luke HEENEY, PhD ScD; (2012); of Open Oceans, British Antarctic Survey Paolo CAMPANA, PhD; (2017); University Lecturer Professor of Comparative Pathology, Department Paul Andrew ROBERTSON, PhD; (2003); University in Criminology and Complex Networks, Institute of Veterinary Medicine Senior Lecturer, Department of Engineering of Criminology Fiona Eve KARET, PhD FMedSci; (2014); Professor Mark Edmondus Jan DE ROND, DPhil; (2006); Jennifer Mary SCHOOLING, PhD FICE; (2018); of Nephrology, Cambridge Institute for Medical Professor of Organisational Ethnography, Judge Director of the Centre for Smart Infrastructure, Research Business School Department of Engineering Michael Edwin AKAM, DPhil FRS; (2006); 1866 James Benedict ROWE, PhD; (2018); Patrick DEAN Professor of Zoology, Department of Zoology Sissons Fellow, Professor for Cognitive Neurology, Duncan James NEEDHAM, PhD; (2013); Associate Dénes SZŰCS, MA PhD; (2007); Reader in Department of Clinical Neurosciences Lecturer, Faculty of History Cognitive Neuroscience and Psychology, Centre for Neuroscience in Education. Honorary Wine Steward VISITING FELLOW DEPUTY DEANS Carl Edward RASMUSSEN, PhD; (2008); Professor Gill PARTINGTON, PhD; (2018); Munby Research Matthew Russell JONES, PhD; (1992); Reader in of Machine Learning, Department of Engineering Fellow in Bibliography, University Library Information Systems, Judge Business School Christopher Guy SANDBROOK, PhD; (2011); Sara Theresa BAKER, PhD; (2012); University Senior Lecturer in Conservation Leadership, RESEARCH FELLOWS Lecturer in Psychology and Education, Faculty of Department of Geography Benjamin David RAYNOR, PhD; (2015); Moses Education Russell Paul COWBURN, PhD ScD FRS; (2011); and Mary Finley Research Fellow, Faculty of Professor of Experimental Physics, Cavendish Classics, Fellow Librarian BURSAR Laboratory Tanya HUTTER, PhD; (2015); Henslow Research John Tannatt DIX, LLB MA; (2014) Thomas Jeffrey MILEY, PhD; (2011); Lecturer in Fellow, Department of Chemistry Political Sociology, Department of Sociology Thomas Joseph MAGUIRE, PhD; (2015); Research COLLEGE SECRETARY Jan Dietrich Karsen LÖWE, PhD FRS; (2012); Fellow, Department of Politics and International Julian Graham EVANS, MA; (2014); Secretary, Honorary Professor, Director, MRC Laboratory of Studies School of Humanities and Social Sciences Molecular Biology Arthur Dale DUDNEY, PhD; (2016); Leverhulme Panayiotis ANTONIOU, PhD; (2012); University Early Career Fellow, Faculty of Asian and Middle DEVELOPMENT DIRECTOR Senior Lecturer in Educational Leadership and Eastern Studies Samuel Oliver VENN, BA; (2017) Evaluation, Faculty of Education Daniel Matthew STORISTEANU, PhD; (2016); Paul Stuart ANDERSON, PhD; (2013); University Postdoctoral Researcher, Department of Medicine PROFESSORIAL AND OFFICIAL FELLOWS Senior Lecturer in Middle Eastern Studies, Faculty Tao LIU, PhD; (2016); Research Fellow, Simon John SCHAFFER, MA PhD; (1984); of Asian and Middle Eastern Studies Department of Chemistry Professor of History of Science, Department of Paul Joseph LEHNER, PhD FRCP FMedSci; Jenny ZHAO, PhD; (2016); Lloyd Dan-David History and Philosophy of Science (2013); Professor of Immunology and Medicine, Research Fellow, Needham Research Institute Sir Harshad Kumar Dharamshi Hansraj Cambridge Institute for Medical Research Alexandra (Sandy) SKELTON, PhD; (2016); BHADESHIA, PhD FREng FRS; (1985); Tata Steel Dame Jane Elizabeth FRANCIS, DCMG PhD; Research Associate, Department of Engineering Professor of Metallurgy, Department of Materials (2013); Director, British Antarctic Survey Miltos ALLAMANIS, PhD; (2017); Postdoctoral Science and Metallurgy Eric WOLFF, PhD FRS; (2013); Royal Society Researcher, Microsoft Research Cambridge Adrian Thomas GROUNDS, DM FRCPsych; Research Professor, Department of Earth Sciences Adrian Vivian WELLER, PhD; (2017); David Mackay (1987); Honorary Research Fellow, Institute of Christine VAN RUYMBEKE, Doctorate, Université Newton Research Fellow, Senior Researcher, Criminology Libre de Bruxelles; (2015); Ali Reza and Mohamed Machine Learning Group Andrew Mawdesley PITTS, PhD; (1990); Professor Soudavar Senior Lecturer, Faculty of Asian and Emily Joan WARD, PhD; (2017); Moses and Mary of Theoretical Computer Science, Computer Middle Eastern Studies; College Praelector Finley Research Fellow, Faculty of History Laboratory Ines BARROSO, PhD; (2015); Senior Group Leader, David Alan FRIEDMAN, PhD; (2017); Junior François -André PENZ, PhD; (1995); Professor of Metabolic Disease Group, Sanger Institute Research Fellow, Faculty of Classics Architecture and the Moving Image, Faculty of Simone Nicole WEYAND, PhD; (2016); Group Charu SINGH, PhD; (2017); Adrian Research Fellow Architecture; Director of Studies in Architecture Leader, Department of Biochemistry Advait SARKAR, PhD; (2017); Microsoft Research Carol Elspeth Goodeve BRAYNE, CBE MSc MD Timothy Nicholas MILNER, MA; (2016); Deputy Fellow, Microsoft Research Cambridge FRCP FFPH; (1995); Professor of Public Health Senior Proctor (2018-19), Ceremonial Officer, Robin REUVERS, PhD; (2017); Schlumberger Medicine, Cambridge Institute of Public Health University of Cambridge; Deputy College Praelector Research Fellow, Department of Applied Anne Carla FERGUSON-SMITH, PhD FRS FMedSci; Angela Mary WOOD, PhD; (2016); University Mathematics and Theoretical Physics (1997); Arthur Balfour Professor of Genetics, Lecturer in Biostatistics, Department of Public Department of Genetics Health and Primary Care

DarwinianTHE 20 Francesco Simone RUGGERI, PhD; (2017); Janet ROSSANT, CC PhD (Hon)ScD FRS FRSC; DISTINGUISHED ASSOCIATES Postdoctoral Researcher, Department of (2017) Dame Diana BRITTAN, DBE Chemistry Elizabeth BLACKBURN, AC FRS FAA FRSN ScD; Mr Edward CHAPLIN, CMG OBE Giancarlo SOAVI, PhD; (2017); Research Associate, (2018) Dr Hermann HAUSER, KBE FRS FREng FInstP Cambridge Graphene Centre and Department of Eric MASKIN, PHD ScD; (2018) CPhys Engineering Simon KEYNES, PHD FBA; (2018) Professor Sheila LEATHERMAN, CBE Samuel George OTTEWILL-SOULSBY, PhD; (2017); The Right Honourable Lord JUDGE (Igor), Research Associate, Faculty of Classics EMERITUS FELLOWS Commissary of the University Jenna Mae Irene Russum DITTMAR, PhD; (2017); Abraham David YOFFE, ScD; (1964) Wellcome Trust Research Fellow, McDonald Philip Murray Jourdan MCNAIR, PhD DPhil; (1965) SENIOR MEMBERS Institute for Archaeological Research Reginald Frederick William GOODWIN, MA PhD Ms Saumya BALSARI; Katja Sabina KEVIC, PhD; (2018); Microsoft MRCVS; (1966) Dr Thorsten BOROVIAK; Department of Research Fellow, Microsoft Research Cambridge Donald James WEST, MD LittD; (1967) Physiology, Development and Neuroscience Iosifina Petrina FOSKOLOU, PhD; (2018); Patrick Bruce Anthony NEWTON, ScD FRCPath; (1968) Dr Giorgio DIVITINI; Electron Microscopy Group Sisson Evelyn Trust Research Fellow, Department George Thomas GÖMÖRI, MA BLitt; (1969) Dr David FELLER; Research Operations Office of Physiology Chester WHITE, MBE TD MA BM PhD; (1969) Dr John GABBAY; Cambridge Institute of Public Leah ASTBURY, PhD, (2018); Wellcome Trust Paul RIES, MA PhD; (1973) Health Research Fellow, Department of History and Roger George WHITEHEAD, CBE MA PhD Professor David GANZ Philosophy of Science FIBiol;(1973) Dr Angela GONCALVES; Wellcome Sanger Miguel ANAYA, PhD, (2018); Schlumberger Elisabeth Somerville LEEDHAM-GREEN, MA PhD; Institute Research Fellow, Cavendish Laboratory (1973); Honorary Archivist Dr Stefan GRAF; Department of Medicine Hong GE, PhD, (2018); Postdoctoral Researcher, Peter Furneaux FRIEND, MA PhD; (1974) Dr Anthony HOTSON; Centre for Financial History Machine Learning Group Nicholas JARDINE, MA PhD; (1975) Professor Nicholas HUMPHREY; Rebecca Vanessa BERRENS, (2018); PhD; Charles Dean Ullathorne HAWKES, MA PhD RIBA; (1976) Dr Harriet HUNT; Department of Archaeology and Katharine Darwin Research Fellow Richard HENDERSON, CH, PhD, FRS; (1981) Dr Daniel JONES; British Antarctic Survey Ronald Alfred LASKEY, CBE PhD FRS; (1982) Professor Adrian KENT; Department of Applied HONORARY FELLOWS Nicholas James Bertram Alwyn BRANSON, MA Mathematics and Theoretical Physics; Director of Christopher Michael Paley JOHNSON, MA PhD; PhD; (1983) Studies in Mathematics (1978) Janine Delysia BOURRIAU, MA FSA; (1983) Professor Andreas KONTOLEON; Department of Sir Arnold Stanley Vincent BURGEN, MA MD FRCP Andrew Christopher FABIAN, OBE MA PhD FRS; Land Economy FRS; (1982) (1983) Professor Ioannis KONTOYIANNIS; Department of Sir Geoffrey Ernest Richard LLOYD, PhD FBA; Leopold Eftimios Anagnostis HOWE, MA PhD; Engineering (1985) (1986) Dr Richard LANGFORD; Cavendish Laboratory Sir Michael Francis ATIYAH, OM PhD (Hon) ScD Richard Ashton KING, CBE MA FBIM; (1986) Dr Noelle L’HOMMEDIEU FRS FRSE FMedSci FREng; (1992) Mohammad Munawar CHAUDHRI, PhD; (1990) Dr Celia MARTINEZ; Cancer Research UK Jeffrey William EDINGTON, BSc PhD DSc; (1998) Kathleen Michelle WHEELER, PhD; (1990) Cambridge Institute Amartya Kumar SEN, CH MA PhD (Hon) LittD FBA Karalyn Eve PATTERSON, FRS FMedSci FBA; (1991); Dr Derek MATRAVERS; Open University FRSE; (1998) Margaret CONE, PhD; (1992) Dr Eyal MAORI; Cambridge Infectious Diseases Michael Charles SHEPPARD, MA DPhil; (2000) John Robert COOPER, PhD; (1993) Dr Seán Ó HÉIGEARTAIGH; Centre for Research in Sir Charles Antony Richard HOARE, DSc FRS; Kiyoshi NAGAI, PhD FRS; (1993) the Arts, Social Sciences and Humanities (2001) Jennifer Alice CLACK, MA ScD FRS; (1997) Dr David PEARSON; Ekhard Karl Hermann SALJE, PhD FRS; (2002) Richard Anthony COX, ScD; (1999) Dr Anna PETRUNKINA; Department of Medicine The Honourable Robert Anthony RAYNE; (2004) William Arthur BROWN, CBE MA; (2001) Professor Gloria PUNGETTI; Chairman, Darwin The Lord REES of LUDLOW (Martin John), OM PhD Martin Kenneth JONES, PhD FBA; (2001) College Alumni Society (Hon) ScD FRS; (2004) Peta Margaret STEVENS, MA; (2001) Mr Nebojsa RADIC; The Language Centre Bernard Michael de Lerisson CAZENOVE; (2005) Peter John BRINDLE, MA MPhil FCMI FinstD; Professor John RUST; The Psychometrics Centre Dame Jean Olwen THOMAS, DBE MA ScD FRS (2001) Professor Stoyan SMOUKOV; Department of FMedSci; (2007) Felicia Adina HUPPERT, PhD; (2002) Materials Science and Metallurgy Robert Hughes JONES, PhD; (2008) Ian MCCONNELL, MA PhD MRCVS FRCPath FRSE; Dr Daniel WUNDERLICH; School of Arts and Simon Hastings BITTLESTON, PhD; (2013) (2003) Humanities Christopher Martin DOBSON, DPhil ScD FRS Christopher CULLEN, MA PhD; (2005) FMedSci; (2014) Philip DAWID, MA ScD; (2007) POSTDOCTORAL RESEARCH AFFILIATES Sir Alan Roy FERSHT, PhD FRS FMedSci; (2014) Lawrence W SHERMAN, PhD; (2009) Dr Aya BEN-YAKOV; Cambridge Neuroscience Sir Gregory Paul WINTER, CBE PhD FRS FMedSci; Dr Lorena ESCUDERO; Cavendish Laboratory (2014) BYE-FELLOWS Dr Jessie HITCHCOCK; CRUK Cambridge Centre Nicola Margaret PADFIELD, MA DipCrim DES; Catherine Morag Elisabeth HOWIE, (2018) Dr Anna PROTASIO; Sanger Institute (2014) Professor Arokia NATHAN; Department of Robin Wayne CARRELL, PhD FRS FMedSci; (2015) Engineering, (2018) Olga KENNARD (Lady BURGEN), OBE (Hon) ScD FRS; (2016)

WINTER 21 2018/19 Darwin College Register 2018

RESEARCH ASSOCIATES New Members of the Fellowship Charu SINGH Dr Domagoj BARETIC; MRC Laboratory of (Adrian Research Fellow) Molecular Biology 2018 Academic Year Department: History and Philosophy of Science Dr Dario BRESSAN; Cancer Research UK Research Interests: History of science, knowledge Cambridge Institute This year we are pleased to have inducted the and empire; South Asian history Dr Sara CAVIOLA; Department of Psychology following people to the Fellowship. Welcome to Advait SARKAR Dr Lincoln COLLING; Department of Psychology them all, their input into the College is very much (Microsoft Research Fellow) Dr Sylvain DELAUNAY; Department of Genetics appreciated. Department: Microsoft Research, Cambridge Dr Claudio FALCO; Department of Engineering Research Interests:The future of humanity in the Dr Jonas GELDMANN; Department of Zoology FELLOWS age of artificial intelligence, and universal data Dr Mustafa KAMAL; Department of Engineering Paolo CAMPANA literacy. Dr George LANSBURY; Institute of Astronomy Department: University Lecturer in Criminology and Complex Networks, Institute of Criminology Dr Dmitry MAZUNIN; MRC Laboratory of Robin REUVERS Research Interests: Organised crime and forms Molecular Biology (Schlumberger Research Fellow) of extra-legal governance. Corporate crime Dr Elizabeth MONIER; Faculty of Asian and Middle Department: Department of Applied Mathematics and fraud; trust, reputation and mechanisms of Eastern Studies and Theoretical Physics cooperation in illegal settings. Dr Nozomi TAKAHASHI; Department of Genetics Research Interests: Mathematics of Bose gases, Dr Holly WINTON; British Anartic Survey Jennifer SCHOOLING fermionic antisymmetry, many-body quantum Department: Director of the Centre for Smart physics, related topics in quantum information POSTDOCTORAL ASSOCIATES Infrastructure (CSIC), Department of Engineering and mathematical analysis. Dr Adam ATTAHERI; Department of Psychology Research Interests: CSIC is an Innovation and Francesco RUGGERI Dr Elise BIERSMA; British Antartic Survey Knowledge Centre (IKC) with the specific aim Department: Department of Chemistry Dr Jotis BORONAS; Department of Earth Sciences to transform infrastructure through smarter Research Interests: Biophysics and Biophysical Dr Eleanor CAMPBELL; Department of Biological information. Sciences Chemistry James ROWE Dr Jude CASTELINO; Department of Earth Giancarlo SOAVI (Patrick Sissons Fellow) Sciences Department: Cambridge Graphene Centre and Department: Director and Principal Investigator, Dr Chrispin CHAGUZA; Department of Biological Department of Engineering Cambridge Centre for Frontotemporal Dementia Sciences Research Interests: Photonics and Optoelectronics and related disorders, Department of Clinical Dr Stephanie DIEPEVEEN; Department of Politics Baseed on Graphene and Related Materials and International Studies Neurosciences Dr Jochen DREYER; Department of Chemical Research Interests: Dementia, Frontotemporal Samuel OTTEWILL-SOULSBY Engineering and Biotechnology dementia, Action control and decision making, Department: Faculty of Classics Dr Shoven DUTTA; Cavendish Laboratory Progressive Supranuclear Palsy, Corticobasal Research Interests: Part of the ERC funded Impact Dr Avishai GILKIS; Institute of Astronomy degeneration, Successful cognitive ageing, of the Ancient City project based in the Faculty Dr Natalia GOMES NAVARRO; Department of Parkinson’s disease, Alzheimer’s disease, Primary of Classics, investigating the legacy of classical Biological Sciences Progressive Aphasia. thought of the city on medieval urban ideals. Dr Thomas GRUNER; Cavendish Laboratory Early medieval history, particularly in its politics, Dr Nancy HIGHCOCK; Department of RESEARCH FELLOWS specialising in frontiers and diplomacy, and contact Archaeology Adrian WELLER between Christians and Muslims in the period. Dr Max HOLLOWAY; Department of Geography (David Mackay Newton Research Fellow) Department: Senior Researcher, Machine Learning Jenna DITTMAR Dr Nanna KAALUND; Scott Polar Research (Wellcome Trust Research Fellow) Institute Group Research Interests: Broad interests across machine Department: McDonald Institute for Dr Leon KAPETAS; Department of Engineering Archaeological Research Dr Tim KIETZMANN; Medical Research Council, learning and artificial intelligence (AI), their applications, and their implications for society, Research Interests: Examining the historical Cognition and Brain Sciences Unit and biological effects of the Medieval plague Dr Emma LAWLOR; Medical Research Council, including: scalability, reliability, interpretability, fairness, privacy, ethics, safety and finance. epidemic. Archaeological, historical and genetic Epidemiology Unit (aDNA) studies will enable a discussion about Dr Lucy MACGREGOR; Cambridge Neuroscience Emily WARD the previously unstudied consequences by Dr Bishara MARZOOK; Department of Biological (Moses and Mary Finley Research Fellow) revealing how the plague changed human well- Sciences Department: Faculty of History being, activity, mobility, health and the genetic Dr Charles MORGAN; Department of Biological Research Interests: Male adolescence and the constitution of Europe. Sciences barriers between childhood and adulthood in the Dr Ioannis POLITIS; Department of Engineering central Middle Ages. Katja KEVIC Dr Monica RAMSEY; Department of Archaeology (Microsoft Research Fellow) Dr Souvik ROY; Department of Chemistry David FRIEDMAN Department: Microsoft Cambridge Dr Enric STERN-TAULATS; Department of Materials Department: Faculty of History Research Interests: Mining repositories of software Science and Metallurgy Research Interests: Flavius Josephus, ancient projects to better support developers in their Dr Kaveesha WIJESINGHE; Department of historiography, ancient ethnography. programming tasks. Recommending relevant Pathology places in the source code when performing a Dr Joseph ZHANG; Department of Chemistry change task or when navigating the source code.

DarwinianTHE 22 Iosifina FOSKOLOU Graduands presented James HADFIELD (Patrick Sisson Evelyn Trust Research Fellow) Analysis of an intracellular bacterium using Department: Department of Physiology July 2017–July 2018 population genomics and data visualisation. Research Interests: The role of hypoxia-inducible Sophie MORGAN metabolites in cancer immunology PhD: Prion-like properties of assembled human alpha- synuclein. Leah ASTBURY Applied Mathematics: Oliver PALMER (Wellcome Trust Research Fellow) Giles SHAW Computational analysis of pathogenic mutations in Department: History and Philosophy of Science Liftings, young measures, and lower semicontinuity. mitochondrial diseases using machine learning and Research Interests: Marriage and health in early interaction network topology. modern England. Applied Mathematics and Theoretical Thomas RENSCH Miguel ANAYA Physics: Applications for ChIP-sequencing data reusability. (Schlumberger Research Fellow) Marine DUPOIRON James STOWELL Department: Cavendish Laboratory The effect of gas on multi-stage mixed-flow Targeting poly(A) tail removal with an MMI1 bound Research Interests: Optoelectronic properties of centrifugal pumps: flow visualisation and modelling. CCR4-not complex. emerging semiconductors. Maciej SZUKSZTO Archaeology: Regulation of Mammalian mitochondrial gene Hong GE expression: new factors and approaches. Department: Machine Learning Group Yiru WANG Identifying the beginnings of sheep husbandry in Research Interests: Machine Learning, Probabilistic Chemical Engineering: Programming, Bayesian Nonparametrics. western China. Thomas BLYTHE Rebecca BERRENS Asian and Middle Eastern Studies: Taking magnetic resonance into industrial applications. (Charles and Katharine Darwin Research Fellow) Yuhsin HUANG Tian TIAN Department: Cancer Research UK A cross-linguistic comparison in the L2 acquisition of The development of monolithic metal-organic Research Interests: Transposable elements in Chinese applicative double object constructions and frameworks. mammalian development. double unaccusative constructions. Zehavit ZASLANSKY HONORARY FELLOWS Melancholy and modernity in diasporic Hebrew Chemistry: Elizabeth BLACKBURN, AC FRS FAA FRSN SCD poetry. Raphaele CLEMENT Biography: Matriculated at Darwin 1971, PhD First principles DFT and solid-state NMR studies of Biology. Elizabeth discovered the molecular Biochemistry: sodium transition metal oxides for rechargeable Na- nature of telomeres - the ends of eukaryotic ion battery applications. Mona BASSUNI chromosomes that serve as protective caps Rosemary FREER Dynamics and architecture of a mycolactone essential for preserving the genetic information - Molecular origins of tissue vulnerability to aberrant polyketide synthase module. and the ribonucleoprotein enzyme, telomerase. aggregation in protein misfolding diseases. Samuel MYERS She received an Honorary Degree from Oscar MENDEZ LUCIO Determining the signalling pathways that govern Cambridge in 2017 and the Nobel Prize for Bioactivity and selectivity analysis of Kinase human naïve pluripotency. Physiology or Medicine in 2009. Inhibitors. Janaina NASCIMENTO Florian ROESSLER Eric MASKIN, PHD SCD Cordon usage determines mRNA levels in Development and applications of structure based Biography: Eric was a visiting student at Darwin Trypanosoma brucei. force field parameters in molecular dynamics 1975-76. An economist and co-winner of the simulations. 2007 Nobel Prize in Economics ‘for having laid the Biological Anthropology: Ingrid VAN DER WATEREN foundations of mechanism design theory’. He is Denis MUKHONGO Effects of C-terminal truncation and lipid interactions the Adams University Professor at Harvard and Matrilineal, phenotypic diversity and possible on the aggregation of α-synuclein. has made contributions to game theory, contract nutritional adaptation among the Turkana in north- Yuteng WU theory, social choice theory, political economy, western Kenya. Double-click peptide stapling strategies for inhibiting and other areas of economics. He received an protein-protein interactions. Honorary Degree from Cambridge in 2017. Biological Science: Simon KEYNES, PHD FBA Kamilla ERIKSEN Clinical Neurosciences: Biography: Simon Keynes is the Elrington and Maternal nutrition, breast milk micronutrients and Daire ROWLANDS Bosworth Professor of Anglo-Saxon and Fellow infant growth in rural Gambia. The role of the extracellular matrix modifications in of Trinity College. He has been a fellow of Trinity Dominic EVANS central nervious system plasticity. College since 1976. From 1999 to 2006 he was A midbrain mechanism for computing escape head of the Department of Anglo-Saxon, Norse decisions in the mouse. Computer Science: Karol FIEDORCZUK and Celtic. He is a fellow of the Royal Historical Kiela DOUWE Cryo-electron microscopy studies on ovine Society, the Society of Antiquaries of London and Deep embodiment: grounding semantics in mitochondrial complex. the British Academy. perceptual modalities. Poppy GOULD The role of DNA repair in DNA methylation dynamics.

WINTER 23 2018/19 Darwin College Register 2018

Criminology: Andrea MASI History and Philosophy of Science: Jennifer BARTON-CROSBY Eddy-resolving simulations of the flow around a Matthew DRAGE Situational action theory and intimate partner vertical tail plane. “Universal Dharma”: authority, experience and violence: an exploration of morality as the underlying Andrew MELZER metaphysics in the transmission of mindfulness- mechanism in the explanation of violent crime. Aerodynamics of transonic Turbine trailing edges. based stress reduction. Bella NGUYEN Carl FISHER Development Studies: Vision-based over-height vehicle detection for Early Darwinian commemoration in Britain, 1882- Zhenyu FU warning drivers. 1914. What factors determine the success and failure of Ying QIN innovation in China? A systemic study of the Chinese Assessing the water, energy and land nexus in China. Law: mining industry. Christoph SCHREIBER Jason ALLEN Guy WILLIAMS Inlet recirculation in radial compressors. Judicial review of non-statutory executive power: Change in China’s banking sector as an institutional William WEBSTER ultra vires and the common law. evolution. The production of radionuclides for nuclear medicine Gabriel BOTTINI from a low-energy, high-current compact particle Admissibility in investment arbitration: standing Earth Sciences: accelerator. causes of action, and damages. Andrew HOWELL Tsung-Hsien WEN Coastal tectonics and tsunami generation in the Recurrent neural network language generation for Materials Science: eastern Mediterranean. dialogue systems. Michael COTO Tajudeen TAJUDEEN Marco ZACCARIA Harnessing the photochemistry of TiO2 based Coupling source term, mineral reactivity and flow in Bi-tempered glass. nanocomposites. radionuclide transport. Subhankar DAS BAKSHI Moon Hyo KANG English: Wear of fine pearlite, nanostructure bainite and Optimisation of transfer and doping of polymer Ezra HORBURY martensite. supported CVD graphene. Early modern prodigal sons: the parable, prodigality, Hanwei FU Thomas WILLIAMS and filiality. Microstructural alterations in bearing steels under Investigating the circulation of southern ocean rolling contact fatigue. deep water masses over the last 1.5 million years by Genetics: Arunim RAY geochemical fingerprinting of marine sediments. Amanda ANDERSSON-ROLF Niobium microalloyed rail steels. Application and development of advanced genetic Economics: tools to study adult stem cells. Medical Science: Jan KVASNICKA Gianmarco MASTROGIOVANNI Rajbir BATRA Essays in optimal fiscal policy. Establishment of new human and mouse liver Decoding the regulatory role and epiclonal Cherry MUIJSSON cancer models and their use to uncover the role of dynamics of DNA methylation in 1482 breast Topics in systematic risk and financial RNF43 and ZNRF3 in liver homeostasis and repair. tumours. connectedness. Alessandra MERENDA Guinevere GRICE Development of a new screening system for Decoding Lysine-11signals in ubiquitination. Education: the identification of RNF43-related genes and Rui MAURICIO Ekaterina MACE-NAZINA characterisation of other PA-RING family members. Understanding of the Shigella virulence factor IcsA The impact of childhood international mobility on and the interaction with N-WASP. cultural identity. Geography: Daniel WRIGHT James LESTER Investigating the relationship between markers of Engineering: Investigating patterns of disease and transmission at ageing and cardiometabolic disease. Adedayo ABINUSAWA a wildlife-human interface in Western Uganda. Growth investment matrix - a framework linking James TEMPEST Medicine: corporate venture capital investment with business Hydrodynamic effects of salt marsh canopies and Ali ALISAAC growth strategy. their prediction using remote sensing techniques. Understanding functional mechanisms of genetic Philipp BRAEUNINGER-WEIMER Nicholas WILKINSON susceptibility to mycobacterial infection. Fundamentals of CVD enabled graphene Conserving the unknown: decision-making for the Joel CHAPPELL manufacturing and integration. critically endangered Saola Pseudoryx nghetinhensis Vascular smooth muscle cell heterogeneity and Martin FELLE in Vietnam. plasticity in models of cardiovascular disease. Telecom wavelength quantum devices. Albert LILEY Fabio GIARDINA Haematology: Statistical co-analysis of high dimensional On the discretisation of locomotion dynamics: Jan BOTTHOFF association studies. impulse- and shape-based modelling for hopping Loss of rad51 in zebrafish (Danio rerio): a novel Daniela RODRIGUEZ-RINCON robots. Fanconi anaemia model. Tackling mycobacterium abscessus infection in cystic Yingzhen LI Francesca NICE fibrosis. Approximate inference: new visions. The effect of DNMT3A mutations in Tiziana ROSA Edouard MACHOVER myeloproliferative neoplasms. Protection against myocardial infarction by Spark ignition in annular combustors. decreasing mitochondrial oxidative stress.

DarwinianTHE 24 Music: Hannah JONGSMA ScD: Ariana PHILLIPS-HUTTON The role of the sociocultural context in explaining Is sorry really the hardest word? Guilt, forgiveness, variance in incidence of psychosis and higher rates of Clinical Medicine & Clinical Veterinary and reconciliation in contemporary music. disorder in minorities. Medicine: Thomas WILDER Pietro MASTROENI The forging of an icon: the violin in nineteenth- Psychology: century London. Amy DEVINE Cognitive and emotional mathematics learning EngD: Pathology: problems in primary and secondary school students. Justyna KUCIA-TRAN Tomas FOLKE Engineering: Investigating Oncostatin M receptor as a novel The pragmatics of confidence in perceptual and Matthew APPLETON therapeutic target in squamous cell carcinoma. value-based choice. Carina PEREIRA LLM: The Influenza A virus NS1 protein and viral mRNA Public Health and Primary Care: nuclear export. Kenneth EKORU Law: Towards reliable evidence for tackling Akber AHMED Physics: cardiometabolic disease in sub-Saharan Africa. Ajebodunde AJENIFUJA Matthew APPLEGATE James BLAKER Quantum random number generation by photon Pure Mathematics: Michal HABAS number detection. Alberto COCA CABRERO Shuk Kwan HUNG James HAMP Efficient nonparametric estimation of discretely Sheriar KHAN Collective phenomena in pyrochlore and kagome observed compound Poisson processes. Candice LAU frustrated Ising magnets. Irena MADELLA Cheng LI Social and Developmental Psychology: Shivankar SHARMA Metal oxide films for optoelectronic device Jennifer LANDT Tomáš STŘELEČEK application. Wanting to help others. Eugene TAN Zachary RUFF Lee TING HAN Towards colloidal self-assembly for functional Sociology: materials. Torsten GEELAN MASt: Trade unions and the media: exercising and Physiology, Development and revitalizing power after the financial crisis of 2008. Applied Mathematics: Neuroscience: Julieta PALMA Adam CHALABI Björn AÐALSTEINSSON Extended living arrangements in Chile: an analysis of Christian ESPARZA LOPEZ Roles and imprinting of Dlk1 and Rtl1 during skeletal subfamilies. Thomas GRIMM muscle development and regeneration. Moritz LAYER Philipe MENDONÇA Theoretical and Applied Linguistics: Cheng-Tai LEE Mechanisms of irregular spiking and firing dynamics Eleni SAVVA Abhay SHRESTHA in cortical oscillations. Subsentential speech from a contextualist Christopher WEYRER perspective. Pure Mathematics: Molecular mechanisms of presynaptic plasticity and Rylan GAJEK-LEONARD function in the mammalian brain. Veterinary Medicine: Iason KOUNTOURIDIS Samuel STUBBS Siavash LASHKARIGHOUCHANI Plant Sciences: The virome in primary and secondary Torben SELL Alex CANTO PASTOR immunodeficiency. Yulun WANG Small RNAs in tomato: from defence to development. Patrick DICKINSON Zoology: Mathematical Statistics: An investigation of warm temperature induced gene Thomas CLAY Zhen DAI expression in Arabidopsis. Drivers of variation in the migration and foraging Kusti SKYTÉN strategies of pelagic seabirds. WEI ZONG Polar Studies: Elizabeth GREEN Ciaran ROBB Population responses to climate change of two Using semi-automated methods to map glacial European warbler species. MBA Business Administration: geomorphology from remotely sensed data. Joaquim JACOB Rachel ADELMAN Behavioural and electrophysiological analysis of the Andrey ANDREEV Psychiatry: singing central pattern generator network in crickets: Dayne BARTSCHT Shayanti CHATTOPADHYAY MUKHERJEE implications for the evolution of song patterns. Jonathan DE GROOT Brain connectivity in adolescents with major Ana MOSTERIN HOPPING Rohhan DIVANJI depressive disorder. Improvements to influenza vaccine strategy based Hitomi HAMABA-FURUKAWA on understanding of host immunity and viral David HOGAN evolution. Joseph KOEBELE

WINTER 25 2018/19 Darwin College Register 2018

Douglas PAETZELL Biological Science: Early Modern History: Leela PAMIDIMUKKALA Tu LE Marc DE KNIGHTEN Sheela SANEINEJAD Biological Science (Genetics): Caroline FISH Toshiaki SHIBATA Shuai DING Anastazja GRUDNICKA Billy SUWANTO Eliska ZLAMALOVA Andrew TEEVEN Muhammad TAHIR Biological Science (Zoology): Economic and Social History: MEd Education: Justin KEMP Vanessa MCKAY Milena PAVLICKOVA Claudia FRANZ Marie-Yon STRÜCKER Economic Research: Simon GLENISTER Timothy WONG Henry AVIOMOH Xinyang ZHANG Jakob BERNDT MFin Finance: Paul KOENIG Bioscience Enterprise: Nor Ayuni AMIR Jeremy 0’HANLON Economics: Gustavo CANO OCHOA Lucy WALLACE Danyal ARNOLD Robin LOBO Annabel PETRAKIS Fransiska NOVIANTI Chemical Engineering and Ines POZAS FRANCO Panayot POSHTOV Biotechnology: Laurent RENAUD Luis René RAMÓN ARANA Ines COLIĆ Jun Yin SHIK Yuxiang WANG François STIENNON Xi ZHOU Chemistry: Dustin WALPERT Maureen GEORGES Robert WOODHARD MPhil: Xiaoxu OU Katarina PISANI Education: Katherine BUSSIERE Advanced Chemical Engineering: Julia ERDELMANN Pranav CHOKHANI Classics: Konstantinos LYGOURIS Julieta GARCIA HAMILTON Xueyu HE Advanced Computer Science: James MACKSOUD Andrew MARTIN Soizic LE COURTOIS Sean BILLINGS Anthony LI Catalina CANGEA Preeti NAYAK Clinical Science: Christopher DAVIS Garrett RUBIN Owain JONES Łukasz DUDZIAK Yuan TIAN Hrafn EIRIKSSON Xiangyi ZHA Christos NIKOLAOU Computational Biology: Lorcan REIDY Robert ARCULUS Energy Technologies: Ilia SHUMAILOV Maxime DUVIEUSART Conservation Leadership: African Studies: Carolina SOTO VARGAS Engineering: Noa STEINER Najla AHMAD Amani ZALZALI Nicholas BRICE-BENNETT Pui May WONG Engineering for Sustainable American History: Criminological Research: Development: Jessica BROOKES Daniela KAISER OLHAGARAY Abdul BIN MD DIN Elizabeth STANTON Laura KENNEDY Shivi CHANDNA Ryan DUCHANOIS Criminology: Archaeology: Kyle GRAY Atticus DEPROSPO Alisa SANTIKARN Brendon HARKNESS Bianca RITTER Alicia STEVENS Sorcha NÍ MHUIMHNEACHÁIN Teodora VLAICU Yiru WANG Christina SKONDROGIANNI Fuyu ZHAO Architecture and Urban Design: Development Studies: Luke KON Blandine BENEZIT English Studies: Kah Yun CHIA Karla AL HAGE John HEALEY Melissa FIELDING Papa JACK Anna KASIMATIS Environmental Policy: Assyriology: Hanan TABBARA Ningshan ZHANG Isabel FELANDRO LLANOS Talin Ghazarian Benedict PROBST

DarwinianTHE 26 European, Latin American and Tan SU Public Policy: Comparative Literatures and Cultures: Katerina WRIGHT Kelly FARROW Rossella BUGLIESI Byron HEWSON Management: Real Estate Finance: Finance: Wassila AYOUCH Elise LIGNIERES Maximilian BAUMANN Robin BADLOE Nana Aba DERBY Natalia IOANNOU Julian SPROSSMANN Medical Science: Scientific Computing: Jason TAN Cristina JAUSET GONZALEZ Callum COURT Adiran GARAIZAR Finance and Economics: Medical Science (Clinical James KLIMAVICZ Huaqing CAO Neurosciences): Akshay SRIDHAR Francine CHOI Raquel GOMES ALVES DA CONCEICAO Social and Developmental Psychology: Annie CAFFYN Genomic Medicine: Modern British History: Joshua WONG Maxwell DENTON Social Anthropological Analysis: Jacob FEAR Julian MURRAY Geographical Research: Eamonn O’KEEFFE Grace BURCHELL Sociology: Modern European History: Xiaomin CAI Health, Medicine and Society: Moritz SORG Benjamin TEASDALE Technology Policy: Modern South Asian Studies: Maxime HUERRE Hojeong YOON History and Philosophy of Science and Gaurav DAGA Medicine: Theology and Religious Studies: Topaz HALPERIN Music Studies: Joseph POWELL Anaïs RAMEAU John BOWCOCK Benjamin O’SULLIVAN Theoretical and Applied Linguistics: History of Art and Architecture: Madeleine BOOTH Ksenia PAVLENKO Nuclear Energy: Amanda ROIG MARIN Charlotte SCHELLING Sara ALSHOMALI Kinjal DAVE World History: Samuel AMOS History, Philosophy and Sociology of Una DAVIES Science, Technology and Medicine: Alexander BJORNSON Philosophy: MRes: Vassili CHRISTODOULOU Farbod AKHLAGI-GHAFFAROKH Katie COHEN Alfred COLLINS Future Infrastructure and Built Environment: Joshua EVANS Huanghui DENG Nicholas EMMERSON Socrates ANGELIDES Audrey HARNAGEL Francesca O’HANLON Elizabeth SEGER Physics: Gas Turbine Aerodynamics: Industrial Systems, Manufacturing and Shannon SEAH Pawel PRZYTARSKI Management: Anshul AGARWAL Physiology, Development and Graphene Technology: Carl BRINKMANN Neuroscience: Lianglun LAI Paul JACCARINI Aram-Christopher SAYADIAN Vinay MALHOTRA Ziaena KOPPERNAES Marlena STANIAK Political Thought and Intellectual Integrated Photonic and Electronic Ze Sheng Jonathan TAN Systems: History: Chawit USWACHOKE Conor BOLLINS John WHEATLEY Innovation, Strategy and Organisation: Margot GALEZ Primary Care Research: Nanoscience and Nanotechnology: Alex MONACO TSCHAN Sarah FLYNN Taylor UEKERT

International Relations and Politics: Public Health: Medical Science: Behnam GHARAGOZLI Tereza KAPLANOVA Iain HAY Carly KRAKOW Eleanor TURNER-MOSS Mirian LISCI Sadif MUNIR Adam STREETER Plant Sciences: Jack CURTIS

WINTER 27 2018/19 Events in 2019

Darwin College Lecture Series 2019: Alumni Events: VISIONS The Lady Mitchell Hall, Sidgwick Avenue

18th January 15th February Friday 15th March Friday 14th June Professor Paul Fletcher, Professor Carlo Rovelli, Darwin College Society Reunion Darwin College Society Reunion Cambridge Neuroscience International Centre for Dinner during Formal Hall, and Dinner during Formal Hall, and Visions Theoretical Physics drinks afterwards drinks afterwards Appearance and Physical Venue: Dining Hall and Richard Venue: Dining Hall and Richard 25th January Reality King Room King Room Professor Anya Hurlbert, Newcastle University 22nd February March/April (to be confirmed) Saturday 6th July Colour and Vision Dr Carolin Crawford, Alumni events in Beijing, Darwin College Boat Club 50th University of Cambridge Shanghai and Tokyo Anniversary Event 1st February Viewing the Universe Venue: College gardens and Professor Dan-Eric Nilsson, Thursday 21st March dining hall Lund University 1st March Judge Business School students, Evolution of the Eye Professor Andrew Blake, alumni and Fellows Drinks Sunday 7th July Samsung AI Research Centre Venue: Richard King Room Alumni Garden Party 8th February Computer Vision Venue: College gardens Ms Sophie Hackford, April (to be confirmed) Wired Magazine 8th March Alumni Event in Athens, Greece Saturday 21st September Vision of Future Technology Professor Colin Blakemore, Alumni Buffet Lunch School of Advanced Study Friday 10th May Venue: College gardens and Perception of Visual Space Alumni Reunion Dinner for years dining hall 1964-75 and 1986-96 Venue: Dining Hall and Richard King Room Above: The Beagle Punt. Credit: Fioralmpa Ampilas

Editors: Sophia Smith, John Dix

The editors especially welcome short articles, pictures and news from all our alumni but particularly those overseas.

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Front over image: Photo credit Samuel Venn