Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000702065Cyc: Kandleria vitulina DSM 20405 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari sn-glycerol sn-glycerol glycine betaine phosphate lactose lactose 3-phosphate 3-phosphate gly uracil D-cellobiose D-cellobiose

RS0104625 UraA UgpC UgpC RS0105360 RS0111220 RS0106875

glycine betaine uracil sn-glycerol sn-glycerol lactose 6'-phosphate lactose 6'-phosphate phosphate gly 3-phosphate 3-phosphate D-cellobiose 6'-phosphate D-cellobiose 6'-phosphate

Aromatic Compound Aldehyde Metabolic Regulator Glycolysis Secondary Metabolite Biosynthesis superpathway of pyrimidine Nucleoside and Nucleotide Degradation Degradation Biosynthesis Degradation an inactive an N-formyl-L- an (R)-2- a [bis(guanylyl hydrogen a (1->4)- deoxyribonucleosides degradation a reduced H O a ribonucleoside a reduced a ribonucleoside an L-asparaginyl- diphosphate 2 α chorismate biosynthesis I glycolysis I (from glucose 6-phosphate) ribonucleoside SAM methionylaminoacyl- halocarboxylate molybdopterin) cys formate peroxide Asn -D-glucan L-lactaldehyde N-acetylglucosamine flavodoxin triphosphate thioredoxin triphosphate [tRNA ] GTP ATP ppGpp metabolism 2'-deoxycytidine triphosphate tRNA cofactor formate formate 1,4-alpha- degradation ribonucleoside Aminoacyl-tRNA Charging gln degradation I glucan glutaminyl-tRNA biosynthesis via transamidation D-erythrose reductase chaperone]- triphosphate D-glucopyranose 6-phosphate (anaerobic) HAD family 4-phosphate nucleoside N-acetyl-D- RdgB/HAM1 family non- L-cysteine anaerobic thioredoxin- branching pppGpp 3-deoxy-7- peptide reductase: aminoacyl- (S)-lactaldehyde hydrolase: dependent protein deaminase: glucosamine canonical purine NTP deformylase: ribonucleoside- T513_RS0108970 ribonucleoside ribonucleoside glu phosphoheptulonate anaerobic T513_RS0103120 tRNA bifunctional (p)ppGpp glucose-6-phosphate T513_RS0109330 lactaldehyde 6-phosphateN-acetylglucosamine- pyrophosphatase: rdgB triphosphate thiol GlgB: glgB synthase: thymidine ribonucleoside- T513_RS0106435 cysteine anaerobic hydrolase: triphosphate triphosphate synthetase/guanosine- guanosine 3'- isomerase: reductase: fucO 6-phosphate HAD family reductase: nrdD peroxidase: T513_RS0103090 cytidine deaminase: triphosphate putative manganese- peptide desulfurase: ribonucleoside- pth2 reductase: reductase: 1,4-alpha- 3',5'-bis(diphosphate) 3'- 3-deoxy- T513_RS0107660 pyrimidine- (S)-propane- hydrolase: bcp diphosphate 5'- T513_RS0107545 D-glucosaminedeacetylase: nagA dependent inorganic T513_RS0108970 T513_RS0108970 glucan 1,2-diol reductase deformylase: T513_RS0103215 ribonucleoside triphosphate aminoacyl-tRNA pyrophosphohydrolase: triphosphate 3'- D-arabino- nucleoside T513_RS0105695 6-phosphate activating diphosphatase: T513_RS0102515 triphosphate reductase: nrdD anaerobic anaerobic branching T513_RS0102050 heptulosonate phosphorylase: cysteine a 2'- hydrolase: diphosphatase: F6P 2'-deoxyuridine T513_RS0105465 protein an L-glutamyl- protein: nrdG desulfurase: reductase: an oxidized H O T513_RS0104515 ribonucleoside- ribonucleoside- T513_RS0102050 7-phosphate T513_RS0107075 2 deoxyribonucleoside Gln gln an (S)-2- T513_RS0108970 thioredoxin triphosphate triphosphate GlgB: glgB [tRNA ] anaerobic a halide anion T513_RS0100540 5'-triphosphate α 3-dehydroquinate a L-methionylaminoacyl- hydroxycarboxylate a (1,6)- -D- F0F1 ATP 6-phosphofructokinase: thymine α formate reductase: nrdD reductase: nrdD H + H + Asp-tRNA(Asn) synthase: aroB -D-glucosamine ribonucleoside- + tRNA glucosyl-(1,4) synthase carbamoylphosphate T513_RS0108675 phosphate H a 2'- Asn /Glu-tRNA(Gln) GTP ppGpp 6-phosphate triphosphate a [bis(guanylyl asn tRNA -α-glucan synthase large subunit: [+ 3 isozymes] pyrimidine- deoxyribonucleoside amidotransferase: 3-dehydroquinate class II fructose-1,6- glucosamine- reductase ala molybdopterin) T513_RS0103655 nucleoside 5'-triphosphate gatC gatA gatB bisphosphate aldolase: fba phosphorylase: 6-phosphate activating protein: cofactor dGTP dATP V-type ATP [+ 10 isozymes] type I 3- DHAP β-D-fructose 1,6-bisphosphate H + H + a 5-phosphooxy- nucleoside- superpathway of purine deoxyribonucleosides degradation deaminase: T513_RS12040 chaperone]-S- dehydroquinate T513_RS0107075 synthase L-glutamyl- ammonium diphosphate GDP nagB sulfanyl-L-cysteine dehydratase: aroD [tRNA Gln ] kinase: ndk pyrophosphokinase: bifunctional (p)ppGpp triose-phosphate an active T513_RS0102050 synthetase/guanosine- F6P 5'-deoxyadenosine a flavodoxin 3-dehydroshikimate isomerase: 2'-deoxyguanosine met ribonucleoside biotin RS0106335 biotin Asp-tRNA(Asn) 3',5'-bis(diphosphate) 3'- semiquinone T513_RS0106140 uracil 2-deoxy-α-D- triphosphate /Glu-tRNA(Gln) pyrophosphohydrolase: 2'-deoxyadenosine shikimate ribose 1-phosphate reductase amidotransferase: T513_RS0102050 dehydrogenase: gatC gatA gatB phosphopentomutase: a metal a metal GDP T513_RS0110670 D-glyceraldehyde 3-phosphate purine-nucleoside RS0104550 T513_RS0101335 a pentaglycine cation cation adenosine phosphorylase: 3-aci- an (S)-2- a [ThiI sulfur- phosphoenol DNA combined a (1->4)- 34 a protein with an N-modified H O formate an L-cysteinyl- shikimate 2-deoxy-D-ribose a 5,10-gly a uridine cross-bridge of carrier protein]- cys 2 CTP with exogenous α-D-glucan an L-glutaminyl- deaminase: deoD nitropropanoate NPXTN motif halocarboxylate aminoacyl-[tRNA] GTP dGDP pyruvate [tRNA Cys ] type I glyceraldehyde- methylenetetrahydrofolate in tRNA peptidoglycan L-cysteine DNA to form a 1,4-alpha- [tRNA Gln ] 5-phosphate add purine-nucleoside shikimate kinase: 3-phosphate recombinational glucan a metal a metal purine-nucleoside phosphorylase: nitronate HAD family Holliday T513_RS0100160 dehydrogenase: gap ribonucleoside junction branching cation cation deoxyribose- T513_RS0105675 tRNA uridine-5- class B cysteine aminoacyl- GTPase aminoacyl- junction RS0103135 tRNA charging phosphorylase: monooxygenase: hydrolase: triphosphate protein shikimate 3- phosphate carboxymethylaminomethyl(34) sortase: desulfurase: tRNA pyruvate tRNA resolvase deoD 2'-deoxyinosine T513_RS0106290 T513_RS0103120 HflX: hflX reductase: GlgB: glgB ala ala phosphate 13-DPG aldolase: synthesis GTPase MnmE: mnmE srtB T513_RS0103215 hydrolase: kinase: pyk hydrolase: RecU: recU purine-nucleoside nitronate HAD family [+ 5 isozymes] T513_RS0108970 deoC pth2 pth2 1,4-alpha-a metal a metal serine serine phe a tRNA Phe thr a tRNA Thr asn tRNA Asn ile a tRNA Ile his a tRNA His tRNA asp asp tyr a tRNA Tyr arg a tRNA Arg trp a tRNA Trp elongator tRNA Met met initiator tRNA Met met cys a tRNA Cys glu a tRNA glu 3-phosphoshikimate 1- tRNA uridine-5- cysteine Holliday RS0105810 SstT phosphorylase: purine-nucleoside monooxygenase: hydrolase: anaerobic glucan cation cation Leu Ala Val Pro Gly ser Lys Fatty Acid and carboxymethylaminomethyl(34) a protein with a peptide with desulfurase: aminoacyl-tRNA aminoacyl-tRNA thr thr leu a tRNA a tRNA ala val a tRNA pro a tRNA gly a tRNA ser a tRNA lys a tRNA carboxyvinyltransferase: T513_RS0105675 phosphorylase: T513_RS0106295 T513_RS0105695 H + ribonucleoside- junction Gln phosphoglycerate D-glyceraldehyde Lipid Degradation phosphate branching gln a tRNA aroA acetaldehyde synthesis enzyme MnmG: mnmG NPXT carboxyl an N-terminal T513_RS0100540 hydrolase: GDP pyruvate hydrolase: resolvase 3-phosphate deoD triphosphate resolution of protein phenylalanine- threonine- asparagine- isoleucine- histidine-- aspartate- tyrosine-- arginine-- tryptophan- methionine- methionine- cysteine-- glutamate-- 5-enolpyruvoyl- kinase: T513_RS0106135 end attached to L-asparagine T513_RS0104515 dGTP T513_RS0104515 β [unspecified reductase: nrdD recombinationalRuvX: ruvX a metal a metal purine-nucleoside oleate -oxidation an (S)-2- GlgB: glgB serine serine -tRNA ligase: -tRNA leucine--tRNA ligase: -tRNA alanine--tRNA -tRNA valine--tRNA ligase: tRNA ligase: -tRNA tRNA ligase: proline--tRNA ligase: tRNA ligase: glycine--tRNA ligase: serine--tRNA -tRNA -tRNA -tRNA tRNA ligase: lysine--tRNA tRNA ligase: shikimate 3- bifunctional 34 a pentaglycine RS0106550 RS0111135 phosphorylase: a 5-carboxymethylaminomethyluridine 3-oxopropanoate nitrite degradation a halide anion a [ThiI sulfur- junction cation cation thr thr pheS pheT ligase: thrS T513_RS0100455 ligase: asnS ligase: alaS ligase: ileS T513_RS0101650 T513_RS0102065 ligase: aspS T513_RS0102115 T513_RS0105015 T513_RS0105655 T513_RS0107565 ligase: serS ligase: trpS ligase: metG ligase: metG T513_RS0109285 ligase: lysS T513_RS0110530 phosphate acetaldehyde- a 7,8-dihydrofolate cross-bridge of hydroxycarboxylate a GlgE-glycogen 3-phospho-D-glycerate T513_RS0105675 in tRNA products] ala carrier protein]- formation of two chorismate oleate peptidoglycan an N-modified an uncharged dCTP Cys CoA/alcohol α S-sulfanyl- cys a tRNA intact strands 2-deoxy- -D- amino acid tRNA synthase: dehydrogenase: L-cysteine an L-phenylalanyl- an L-glutaminyl- Thr Leu an L-asparaginyl- Ala Ile Val His asp Tyr Pro Arg Gly ser an L-tryptophanyl- an L-methionyl- an L-methionyl- Cys Lys Glu ribose 1-phosphate a metal a metal serine serine Phe Gln an L-threonyl-[tRNA ] an L-leucyl-[tRNA ] Asn an L-alanyl-[tRNA ] an L-isoleucyl-[tRNA ] an L-valyl-[tRNA ] an L-histidyl-[tRNA ] an L-aspartyl-[tRNA ] an L-tyrosyl-[tRNA ] an L-prolyl-[tRNA ] an L-arginyl-[tRNA ] a glycyl-[tRNA ] an L-seryl-[tRNA ] Trp Met Met an L-cysteinyl-[tRNA ] an L-lysyl-[tRNA ] an L-glutamyl-[tRNA ] aroC 2,3-bisphosphoglycerate- adhE RS0111140 [tRNA ] [tRNA ] [tRNA ] [tRNA ] [elongator tRNA ] [initiator tRNA ] cation cation thr thr independent phosphopentomutase: RS0110115 chorismate inosine 5'-phosphate a mature peptidoglycan RNase III mRNA a mature a [protein] N- phosphoglycerate acetyl-CoA T513_RS0101335 quinoxaline-2- an (S)-2- phosphoenol a glucosylated degradation a D-tyrosyl- a nucleoside formate ala ala mutase: T513_RS0106025 oleoyl-CoA (meso-diaminopimelate aryl-carrier protein processing peptidoglycan terminal-formyl- Tyr RNA UTP glycogenin 2-deoxy-D-ribose carboxyl adenylate halocarboxylate (n) [tRNA ] dADP pyruvate triphosphate GTP containing) substrate (meso-DAP L-methionine 1,4-alpha- 2+ 2+ sulfate RS0110025 sulfate 5-phosphate Cd CadA Cd containing) anaerobic glucan IMP Amino Acid Biosynthesis 2-phospho-D-glycerate HAD family ribonucleoside ribonucleoside- branching endolytic acyl carrier ribonuclease III: peptide D-tyrosyl-tRNA(Tyr) DNA- deoxyribose- hydrolase: triphosphate triphosphate protein pyrimidine IMP dehydrogenase: (2E,9Z)- transglycosylase protein: acpP endolytic deacylase: directed RNA phosphate T513_RS0109290 T513_RS0103120 deformylase: pyruvate 2+ 2+ + + L-histidine biosynthesis phosphopyruvate ribonucleosides T513_RS0100625 reductase: reductase: nrdD GlgB: glgB Cd CadA Cd Na RS0108630 Na superpathway of branched chain amino acid biosynthesis superpathway of L-serine L-lysine biosynthesis III ammonia assimilation cycle III L-alanine octadecenoyl-CoA MltG: mltG acyl carrier protein: transglycosylase T513_RS0106435 T513_RS0100590 kinase: pyk polymerase: aldolase: ribonuclease III: T513_RS0108970 L-glutamate hydratase: eno degradation HAD family rpoC rpoB ribonucleoside 1,4-alpha- and glycine biosynthesis I biosynthesis III deoC XMP T513_RS0105030 T513_RS0103195 MltG: mltG peptide biosynthesis III Fatty Acid and Lipid Biosynthesis cytidine hydrolase: anaerobic triphosphate Secondary Metabolite Biosynthesis PRPP a mature peptidoglycan a mature peptidoglycan [+ 2 isozymes] glucan pyruvate 3-phospho- ammonium nucleoside deaminase: T513_RS0105695 deformylase: thr asp Tyr ribonucleoside- reductase: branching 2+ 2+ chloride RS0102110 chloride cys D-glyceraldehyde with (L-alanyl-γ-D- strand (non- a quinoxaline-2- RNase III a mature GlcNAc-1,6- T513_RS0102515 D-tyrosine a tRNA pyruvate Mg MgtE Mg ATP D-glycerate 2-oxoglutarate phosphoenolpyruvate T513_RS0109330 (S)-3-hydroxy-(9Z) triphosphate T513_RS0108970 biosynthetic-type phosphoglycerate aspartate kinase: 2-oxoglutarate glu palmitate biosynthesis acetaldehyde glutamyl-meso-2,6- reducing terminus) an mRNA fragment peptidoglycan anhMurNAc- dATP protein methylerythritol phosphate pathway I cysteine desulfurase: CDP-diacylglycerol biotin-carboxyl carrier protein assembly 3-phosphate carboxyl-[aryl- processing (n) autoinducer AI-2 biosynthesis I phosphoribosyltransferase threonine dehydrogenase: NADP-specific glutamine synthetase (type II fatty acid synthase) cytidine deaminase: -octadecenoyl-CoA AMP RNA reductase: nrdD GlgB: glgB acetolactate T513_RS0100410 T513_RS0100540 diaminopimeloyl-D- product mRNA a (2R)-2- (meso-DAP L-Ala-γ-D-Glu- dGTP ammonia-lyase: glutamate NADP-specific glutamate III: T513_RS0109175 biosynthesis I T513_RS0107545 bifunctional carrier protein] a halide anion an N-terminal L- regulatory subunit: synthase: ilvN ilvB T513_RS0103695 3-hydroxyacyl-CoA hydroxy fatty acid D-glyceraldehyde L-aspartyl- a [biotin carboxyl- alanine) tetrapeptide containing) DAP-D-Ala formate a glycogen 2+ 2+ 2+ 2+ pyruvate T513_RS0106620 T513_RS0108425 3-phosphooxypyruvate dehydrogenase: dehydrogenase: gdhA glutamine synthetase cysteine desulfurase: uridine acetaldehyde- methionyl-[protein] Mg MgtE Mg Ca RS0110205 Ca 4-phosphate an acetoacetyl-[acp] pyruvate kinase: pyk xanthosine dehydrogenase: dUTP 3-phosphate SAM gdhA [+ 2 isozymes] T513_RS0103215 DHAP carrier protein]-L-lysine CoA/alcohol ATP (S)-2-acetolactate III: T513_RS0104980 pyrimidine-nucleoside T513_RS0103670 (2Z)-2-aminobut-2-enoate 3-phosphoserine/ ala glycerol-3- biotin--[acetyl-CoA- dehydrogenase: phosphoribosyltransferase: [+ 2 isozymes] aspartate- phosphorylase: 1-deoxy-D-xylulose- 3-oxoacyl-[acyl- phosphate 3-oxo-(9Z)- phosphohydroxythreonine carboxylase] ligase: adhE purine-nucleoside 34 an N-terminal- 1939 (E)-4-hydroxy-3- a (1->4)- T513_RS0106615 glu semialdehyde carrier-protein] T513_RS0107075 octadecenoyl-CoA a 5,10- a 2-thiouridine sn-glycerol a CDP- a 2'-deoxyribonucleoside an (R)-2- a D-aspartyl- a uracil a sugar RS0108835 a sugar folate RS0103705 folate 5-phosphate transaminase: serC dehydrogenase: T513_RS11765 pyruvate phosphorylase: deoD a peptide with a aci-nitroethane L-methionyl-L- methylbut-2-en- α dehydrogenase: ammonium gln methylenetetrahydrofolate in tRNA diacylglycerol [DNA] halocarboxylate asp in 23S rRNA -D-glucan synthase: SAH 1-(5-phospho- reductase: fabG acetyl-CoA 3-phosphate 5'-triphosphate leader sequence [tRNA ] ATP T513_RS0100715 a [biotin carboxyl-carrier uracil purine-nucleoside threonyl-[protein] 23S rRNA 1-yl diphosphate 1,4-alpha- β (2R)-2,3-dihydroxy- O-phospho- asd sn-glycerol flavodoxin- T513_RS0101360 -D-ribosyl)-ATP a (3R)-3- 6 anaerobic glucan L-serine protein]-N -biotinyl-L-lysine phosphorylase: (uracil(1939)-C(5)) 5'-methylthioadenosine/ 3-methylbutanoate 2-iminobutanoate L-aspartate 4- 3-phosphate tRNA uridine-5- HAD family nitronate dependent bifunctional hydroxybutanoyl-[acp] T513_RS0105675 DNA polymerase -methyltransferase ribonucleoside- branching a sugar RS0107425 a sugar predicted adenosylhomocysteine semialdehyde CDP-diacylglycerol-- signal type I methionyl D-tyrosyl-tRNA(Tyr) (E)-4-hydroxy- 1-deoxy-D-xylulose phosphoribosyl- dihydroxy-acid glycerol-3- (7Z)-hexadecenoyl-CoA carboxymethylaminomethyl(34) hydrolase: monooxygenase: triphosphate protein 3-hydroxyacyl- Macromolecule Modification glycerol-3-phosphate 3- III subunit aminopeptidase: deacylase: RlmD: rlmD ABC 5-phosphate nucleosidase: dehydratase: ilvD alanine xanthine synthesis GTPase MnmE: mnmE T513_RS0103120 peptidase I: lepB T513_RS0106290 3-methylbut- Peptide Peptide AMP cyclohydrolase/ 4-hydroxy- carbamoylphosphate phosphate 1-O- gamma/tau: dnaX reductase: nrdD GlgB: glgB transporter T513_RS0101250 ACP dehydratase phosphatidyltransferase: signal map T513_RS0100590 23S rRNA 2-enyl- 1-deoxy-D-xylulose- phosphoribosyl- racemization tetrahydrodipicolinate acyltransferase a [biotin carboxyl-carrier-protein purine ribonucleosides degradation tRNA uridine-5- HAD family nitronate synthase large subunit: FabZ: fabZ tRNA-uridine 2-thiolation pgsA [+ 6 isozymes] (uracil(1939)-C(5)) ribonucleoside 1,4-alpha- of a peptide 3-methyl-2-oxobutanoate glu 6 peptidase I: lepB diphosphate predicted 5-phosphate ATP diphosphatase ser synthase: T513_RS0103655 PlsY: plsY dimer]-N -biotinyl-L-lysine carboxymethylaminomethyl(34) hydrolase: monooxygenase: triphosphate S-ribosyl-L-homocysteine 2-oxobutanoate and selenation (bacteria) -methyltransferase synthase: ispG glucan ABC reductoisomerase: HisIE: ala T513_RS0108090 a 1-acyl-sn (2E,7Z)- synthesis enzyme MnmG: mnmG T513_RS0105695 T513_RS0106295 an N-terminal L- 2-C-methyl-D- [+ 10 isozymes] a (2E)-but-2-enoyl-[acp] acetyl-CoA 1-(3-sn- asp RlmD: rlmD reductase: branching a sugar a sugar met RS0106930 met (2S,4S)-4- -glycerol 3- acetyl-CoA CMP met threonyl-[protein] tRNA D-aspartate a 5- erythritol-2,4- transporter T513_RS0101580 T513_RS0106585 2-isopropylmalate branched-chain biosynthetic-type serine alanine carboxylase adenosine hexadecenoyl-CoA [DNA] T513_RS0108970 S-ribosylhomocysteine phosphate cys urate phosphatidyl) 1939 protein of a sugar acetolactate hydroxymethyltransferase: racemase: hydroxy-2,3,4,5- crotonyl-[acyl- carboxylase biotin a leader sequence a peptide methyluracil cyclodiphosphate 1-(5-phospho-β- synthase: leuA amino acid carboxyltransferase a 5-aminomethyl-2- -sn-glycerol a (2R)-2- dATP GlgB: glgB MEP lyase: T513_RS0106905 tetrahydrodipicolinate 1-acyl-sn-glycerol- carboxylase subunit: in 23S rRNA synthase: ilvN ilvB T513_RS0107365 alr carrier-protein] adenosine a 7,8-dihydrofolate 34 a halide anion acetaldehyde nitrite D-ribosyl)-AMP aminotransferase: 3-phosphate subunit beta: cysteine thiouridine in tRNA 3-phosphate hydroxy fatty acid fluoride CrcB fluoride D-ala 4-hydroxy- reductase: fabG T513_RS0106320 starch thiamine RS0100815 thiamine AI-2 T513_RS0101895 (S)-2-aceto-2- L-homocysteine biosynthesis T513_RS0106315 deaminase: 2-C-methyl-D- bifunctional (2S)-2-isopropylmalate tetrahydrodipicolinate acyltransferase: desulfurase: (S)-3-hydroxy-(7Z) hydroxybutanoate gly add erythritol 4-phosphate phosphoribosyl- reductase: a butanoyl-[acp] T513_RS0100140 a [carboxyl-carrier protein dimer]- T513_RS0100540 -hexadecenoyl-CoA AMP cyclohydrolase/ 3-isopropylmalate a 1,2-diacyl- 6 UDP-N-acetyl-α-D-muramoyl- DNA with adenine:7,8- an N-terminal- an N-terminal- cytidylyltransferase: T513_RS0108085 N -carboxybiotinyl-L-lysine cysteine 3-hydroxyacyl-CoA a [DNA]-3'- + a 5'-phospho- val L-homoserine xanthosine adenosine inosine guanosine di-trans,octa-cis- NAD a 2'-deoxyribonucleoside 5'-deoxyadenosine Ala chloramphenicol ala RS0107920 ala phosphoribosyl- dehydratase: sn-glycerol L-alanyl-γ-D-glutamyl-L- [DNA] glu a (6S)-5- dihydro-8- a glycyl-[tRNA ] L-methionyl-L- L-methionyl-L- ser a tRNA sec T513_RS0105080 (S)-2,3,4,5- beta-ketoacyl- desulfurase: dehydrogenase: undecaprenyl phosphate hydroxyl [DNA] 5'-triphosphate ATP roseoflavin ATP diphosphatase leuC leuD 3-phosphate lysyl-D-alanyl-D-alanine formyltetrahydrofolate oxoguanine mismatch CatB-related O- alanyl-[protein] valyl-[protein] [+ 2 isozymes] (2R,4S)-2-methyl-2,4- (R)-2,3-dihydroxy- tetrahydrodipicolinate homoserine O- ACP synthase T513_RS0103215 T513_RS0103670 5'-phosphate dihydroxydihydrofuran-3-one HisIE: phosphatidate an [L-cysteine acetyltransferase: 4-(cytidine 5'- 2-isopropylmaleate 3-methylpentanoate acetyltransferase: II: fabF 3-oxo-(7Z)- NAD- 5'-methylthioadenosine/ T513_RS0106585 cytidylyltransferase: desulfurase]-S- purine-nucleoside purine-nucleoside purine-nucleoside purine-nucleoside phospho-N- DNA polymerase D-tyrosyl-tRNA(Tyr) T513_RS0104090 type I methionyl type I methionyl diphospho)-2-C- metA hexadecenoyl-CoA dependent folylpolyglutamate adenosylhomocysteine A/G-specific serine- dihydroxy-acid T513_RS0101585 phosphatidylserine and phosphorylase: phosphorylase: phosphorylase: phosphorylase: methyl-D-erythritol 1-(5-phospho-β-D-ribosyl)- 3-isopropylmalate a 3-oxohexanoyl-[acp] sulfanyl-L-cysteine acetylmuramoyl- III subunit synthase/ adenine deacylase: CatB-related O- aminopeptidase: aminopeptidase: riboflavin -tRNA dehydratase: ilvD O-acetyl-L- phosphatidylethanolamine DNA ligase nucleosidase: 4-(cytidine 5'- 5-[(5-phosphoribosylamino) dehydratase: a CDP- deoD deoD deoD deoD pentapeptide- gamma/tau: dnaX dihydrofolate glycosylase: T513_RS0100590 acetyltransferase: map map biosynthesis L-α-amino-ε- hydrogen sulfide biosynthesis I LigA: ligA T513_RS0101250 ligase: (2R,4S)-2-methyl-2,3,3,4- leuC leuD homoserine 3-oxoacyl-[acyl- diacylglycerol transferase: T513_RS0102605 protein diphospho)- methylideneamino]imidazole- (3S)-3-methyl-2- keto-pimelate purine-nucleoside purine-nucleoside purine-nucleoside purine-nucleoside [+ 6 isozymes] synthase: mutY serS tetrahydroxytetrahydrofuran carrier-protein] a CDP-diacylglycerol T513_RS0110990 chloramphenicol RibF: ribF 2-C-methyl-D- 4-carboxamide oxopentanoate a [TusA sulfur- phosphorylase: phosphorylase: phosphorylase: phosphorylase: T513_RS0102200 (2R,3S)-3-isopropylmalate L-arginine biosynthesis II (acetyl cycle) diaminopimelate (5Z)-tetradecenoyl-CoA 3-acetate an N-terminal L- an N-terminal erythritol kinase: 1-(5-phosphoribosyl)-5- O-acetylhomoserine reductase: fabG phosphatidylserine T513_RS0105675 T513_RS0105675 T513_RS0105675 T513_RS0105675 5-deoxy-D-ribose Ala branched-chain carrier protein]-S- [DNA] NMN an apurinic site a tRNA gly met alanyl-[protein] met L-valyl-[protein] dehydrogenase: aminocarboxypropyltransferase/ synthase: AMP [DNA] adenine roseoflavin an L-seryl- T513_RS0103845 [(5- phosphoribosylamino) 3-isopropylmalate amino acid a (3R)-3- sulfanyl-L-cysteine undecaprenyl-diphospho-N- UMP N-acetylglutamyl- T513_RS0111150 a (6S)-5- adenine within DNA sec 2-phospho-4-(cytidine methylideneamino]imidazole-4- cysteine synthase: T513_RS0109410 α-D-ribose- γ adenine [tRNA ] dehydrogenase: aminotransferase: phosphate hydroxyhexanoyl-[acp] fatty acid biosynthesis a 3-sn-phosphatidyl- acetylmuramoyl-L-alanyl- -D- 5'-diphospho)-2-C- 1-phosphate formyltetrahydrofolate carboxamide isomerase: hisA leuB T513_RS0101895 meso- T513_RS0105600 initiation (type II) L-serine glutamyl-L-lysyl- D-alanyl-D-alanine dinucleotide preQ biosynthesis 3-hydroxyacyl- methyl-D-erythritol 0 diaminopimelate S-methyl-5'-thioadenosine pyrimidine deoxyribonucleotides (2E,5Z)- phosphoribulosylformimino- (2S)-2-isopropyl- ACP dehydratase phosphatidylserine a [TusD sulfur- phosphopentomutase: 2-C-methyl-D- ile degradation IV dephosphorylation tetradecenoyl-CoA AICAR-phosphate 3-oxosuccinate FabZ: fabZ acetyl-CoA decarboxylase: T513_RS0101335 UDP-N-acetyl-α-D- a [ThiI sulfur- an α-D- a 1-acyl-2- 3''-O-acetyl- an N-terminal- an N-terminal- 34 erythritol 2,4- diaminopimelate L-homocysteine carrier protein]-S- nucleotide methyl β-D-glucoside an adenosine N-acetyl-gamma- acetyl-CoA di-trans,octa-cis- a uracil in tRNA S-methyl-L- decarboxylase: lysA T513_RS0109405 sulfanyl-L-cysteine S-methyl-5'- D-ribose 5- muramoyl-L-alanyl-γ-D- carrier protein]- galactoside arachidonoyl- L-homocysteine 6-phosphate ADP-ribose L-methionyl-L- L-methionyl- in [tRNA Arg2 ] cyclodiphosphate GTP glutamyl-phosphate pyrophosphohydrolase: undecaprenyl phosphate ATP methionine ATP imidazole a (2E)-hex-2-enoyl-[acp] carboxylase an L-1- thioadenosine phosphate glutamyl-L-lysyl-D-alanine S-sulfanyl- a tRNA precursor sn-glycerol seryl-[protein] glycyl-[protein] biotin Flp pilus synthase: GTP reductase: L-cysteine biosynthesis I 5'-methylthioadenosine/ T513_RS0109975 CTP carboxyltransferase L-cysteine 3-phosphate CTP assembly T513_RS0106205 cyclohydrolase glycerol lys L-tryptophan biosynthesis phosphatidylethanolamine adenosylhomocysteine alpha-galactosidase: O-acetyl-ADP- acetylglutamate T513_RS0106370 hexanoyl-[acyl- subunit beta: nucleotide (3E,5Z)-tetradeca- (S)-3-hydroxy-(5Z) 6-phospho-beta- 7,8- phosphate 4-methyl-2-oxopentanoate phospho-N- homocysteine S- ribose deacetylase: type I methionyl type I methionyl complex I FolE: folE a [TusE sulfur nucleosidase: pyrophosphohydrolase: 3,5-dienoyl-CoA -tetradecenoyl-CoA T513_RS0107415 glucosidase: 2-C-methyl-D-erythritol- kinase: argB carrier-protein] T513_RS0106315 tRNA 4- CCA tRNA biotin--[acetyl- ATPase dihydroneopterin synthase: ser carrier protein]-S T513_RS0101250 acetylmuramoyl- phosphatidate methyltransferase: T513_RS0104955 aminopeptidase: aminopeptidase: 2,4-cyclodiphosphate gln N-acetyl-L-glutamate reductase: fabG malonyl-CoA a uridine 34 in tRNA T513_RS0102415 acyl-CoA 3-hydroxyacyl-CoA thiouridine(8) alpha-galactosidase: T513_RS0107170 3'-triphosphate hisF hisH branched-chain glu N-acetyl-L-glutamate gln pentapeptide- nucleotidyltransferase: cytidylyltransferase: mmuM map map CoA-carboxylase] component 5-semialdehyde chorismate serine acetyltransferase: -sulfanylcysteine MTR dCTP dCMP T513_RS0103085 amino acid bifunctional thioesterase: dehydrogenase: synthase T513_RS0105625 [+ 3 isozymes] ligase: TadA: tadA flavodoxin- 6-carboxytetrahydropterin ACP S- transferase: T513_RS0101585 aminotransferase: glutamate N- carbamoyl T513_RS0107805 a hexanoyl-[acp] T513_RS0105830 T513_RS0103670 ThiI: thiI an inosine 34 dependent D-erythro-1- tRNA 2- T513_RS0110990 acetate ADP-D-ribose T513_RS11765 synthase QueD: queD malonyltransferase: α-D- a non an N-terminal an N-terminal Arg2 AICAR (imidazol-4- T513_RS0101895 acetyltransferase/ phosphate synthase: bifunctional anthranilate synthase: O-acetyl-L-serine dUTP diphosphatase: (3E,5Z)- 3-oxo-(5Z)- β-D-glucose in [tRNA ] (E)-4-hydroxy- fabD thiouridine(34) a tRNA a CDP-1-acyl- met met met 6-carboxy-5,6,7,8- T513_RS0105005 T513_RS0105145 beta-ketoacyl- T513_RS0104530 a [ThiI sulfur- a 4-thiouracil galactopyranose galactosylated MeOH L-seryl-[protein] glycyl-[protein] 3-methylbut- yl)-glycerol amino-acid glutamate N- tetradecadienoate tetradecenoyl-CoA containing a 6-phosphate ACP synthase synthase undecaprenyl-diphospho-N UMP carrier protein]- galactose acceptor 2-arachidonoyl- biotinyl-5'- tetrahydropterin 3-phosphate leu acetyltransferase carB acetyltransferase/ O-acetylhomoserine [+ 3 isozymes] in tRNA 2-enyl- L-homoserine II: fabF a malonyl-[acp] MnmA: mnmA dUTP dUMP -acetylmuramoyl-L-alanyl-γ- L-cysteine 3' CCA end glycerol adenylate putative 7- imidazoleglycerol- ArgJ: argJ [+ 2 isozymes] amino-acid aminocarboxypropyltransferase/ diphosphate biosynthesis anthranilate PRPP D-glutamyl-L-lysyl- D-alanine carboxy-7- cysteine synthase: synthase: ispG phosphate acetyltransferase ketoacyl-ACP 34 L-proline carbamoyl phosphate L-ornithine a 3-oxooctanoyl-[acp] a 2-thiouridine deazaguanine dehydratase ArgJ: argJ T513_RS0105600 (3Z)-dodec- (E)-4-hydroxy-3- biosynthesis I synthase III: in tRNA 5-hydroxy-CTP 5-hydroxy-CMP asp anthranilate cysteine synthase A: cysK 3-enoyl-CoA (1S,2R)-1- an N 3 -methyladenine an N-terminal- N-acetyl-D- 2''-O-acetyl- a uridine 38- a peptide with an unstable methylbut-2-en- synthase HisB: hisB 3-oxoacyl-[acyl- T513_RS0106300 37 an L-cysteinyl- (from L-glutamate) N-acetyl-L-ornithine L-tyrosine tRNA uridine-5- hydrogen selenide pyruvate DMAPP an adenosine L-methionyl-L- galactosamine ADP-ribose an N-terminal RecA filament- QueE: queE 3-(imidazol-4- aspartate kinase: phosphoribosyltransferase: trpD O-acetyl-L-serine ser C-(indol-3- in DNA 40 in tRNA Pro 1-yl diphosphate biosynthesis I carrier-protein] in tRNA [tRNA ] yl)-2-oxopropyl T513_RS0100410 cys carboxymethylaminomethyl(34) yl)glycerol cysteinyl-[protein] 6-phosphate RluA family L-methionine DNA complex 7-carboxy-7- glu reductase: fabG an acetoacetyl-[acp] DNA synthesis GTPase MnmE: mnmE pseudouridine 4-hydroxy-3- phosphate L-aspartyl- 3-phosphate O-acetyl-ADP- repair deazaguanine glutamate 5- chorismate N-(5-phosphoribosyl)-anthranilate (2E)-dodec- pyruvate, DNA-3- histidinol-phosphate 4-phosphate a (3R)-3- tRNA uridine-5- O-acetylhomoserine tRNA (adenosine(37)-N6) type I methionyl N-acetylglucosamine- synthase: type I methionyl methylbut-2-enyl phosphate dikinase: methyladenine ribose deacetylase: Cys- protein 7-cyano-7- kinase: proB ornithine chorismate mutase: hydroxyoctanoyl-[acp] 2-enoyl-CoA tryptophan T513_RS0100335 diphosphate transaminase: γ-L-glutamyl carboxymethylaminomethyl(34) aminocarboxypropyltransferase/ -dimethylallyltransferase aminopeptidase: 6-phosphate T513_RS0104955 aminopeptidase: tRNA(Pro) RecO: deazaguanine aspartate- carbamoyltransferase: T513_RS0100165 phosphoribosylanthranilate T513_RS0102220 synthase: trpB glycosylase I: 4-hydroxy-3- reductase: T513_RS0106045 5-phosphate 3-hydroxyacyl- synthesis enzyme MnmG: mnmG cysteine synthase: MiaA: miaA map deacetylase: nagA [+ 5 isozymes] map deacylase: recO synthase semialdehyde argF isomerase: T513_RS0105165 glycerol T513_RS0105175 T513_RS0102635 a pseudouridine 38- a stabilized methylbut-2-enyl prephenate T513_RS0105600 ybaK T513_RS0107605 L-histidinol ACP dehydratase a 5-carboxymethylaminomethyl- degradation I RecA filament- QueC: queC glutamate-5- dehydrogenase: 1-(2-carboxyphenylamino)-1- 6 40 in tRNA diphosphate L-threonine 34 cysteine synthase A: cysK phosphoenol + acetate ADP-D-ribose phosphate prephenate FabZ: fabZ 2-thiouridine in tRNA (S)-3- H N -(3-methylbut- D-galactosamine DNA complex semialdehyde asd deoxy-D-ribulose 5-phosphate pyruvate diphosphate D-glyceraldehyde an N-terminal L- reductase: preQ biosynthesis Carbohydrate Degradation AMP an apurinic site 2-en-1-yl)- acetate 0 dehydrogenase: glycerol hydroxydodecanoyl-CoA 3-phosphate trp 3-methyladenine met cysteinyl-[protein] 6-phosphate met a peptide IPP histidinol- dehydrogenase: 37 T513_RS0107605 L-aspartate 4- indole-3-glycerol phosphate a (2E)-oct-2-enoyl-[acp] within DNA adenosine Pro phosphatase: T513_RS0104400 T513_RS0109510 3-hydroxyacyl-CoA acetate cys a tRNA semialdehyde synthase TrpC: trpC L-selenocysteine in tRNA 3-(4- L-homoserine glycogen degradation II dehydrogenase: T513_RS0104300 octanoyl-[acyl- a 5-aminomethyl-2- L-glutamate-5- homoserine hydroxyphenyl) D-galactose degradation I (Leloir pathway) L-citrulline homoserine kinase: 34 glycerol T513_RS0103670 histidinol semialdehyde (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate carrier-protein] thiouridine in tRNA dehydrogenase: pyruvate T513_RS0103640 a glycogen reductase: fabG glycerol 6 T513_RS0105860 argininosuccinate tyrosine O-phospho- β-D-galactopyranose 3-oxododecanoyl-CoA an N -L- p-nitrophenyl-α-D- a β-D- guanosine 2251 a supercoiled D-sedoheptulose a mismatched histidinol tryptophan synthase: kinase a sulfurated 37 an acyl-[acyl- a tripeptide O-ureido-L- a cytidine 34 DMAPP synthase: aminotransferase: L-homoserine glycogen/starch/ threonylcarbamoyladenine DL-allothreonine galactopyranoside fructofuranoside asp in 23S rRNA duplex DNA 1,7-bisphosphate lys DNA base pair an octanoyl-[acp] carrier protein] Ile2 dehydrogenase: L-asparagine L-homoserine T513_RS0103745 trpB T513_RS0105175 alpha-glucan galactose GlpK: glpK [sulfur carrier] in tRNA homoserine 23S rRNA UvrD-helicase in tRNA DNA T513_RS0106380 a 5-methylaminomethyl- hisD biosynthesis I (S)-1-pyrroline- threonine synthase: phosphorylase: mutarotase: (guanosine(2251) domain-containing mismatch ser beta-ketoacyl- 2-thiouridine 34 in tRNA sn-glycerol alpha-galactosidase: 5-carboxylate L-arginino-succinate tyr indole T513_RS0103645 T513_RS0106855 sucrose-6- class II T513_RS0104500 3-phosphate phosphate serine peptidase argininosuccinate -2'-O)- protein: repair histidinal ACP synthase tRNA (N(6)-L- T513_RS0107415 phosphate fructose-1,6- tRNA asp pyrroline-5- decanoyl-CoA T: pepT methyltransferase T513_RS0102555 protein II: fabF glycogen/ α-D-galactopyranose threonylcarbamoyladenosine(37) acyltransferase hydroxymethyltransferase: synthase: lysidine(34) argininosuccinate thr alpha-galactosidase: hydrolase: bisphosphate histidinol asparagine carboxylate PlsX: plsX T513_RS0107365 T513_RS0106380 RlmB: rlmB [+ 2 isozymes] MutS: mutS tryptophan synthase: starch/alpha- -C(2))- methylthiotransferase T513_RS0103085 T513_RS0106920 2-O- aldolase: fba synthetase a properly dehydrogenase: synthase reductase: lyase: argH a 5-methylaminomethyl- a single trpB T513_RS0105175 a 3-oxodecanoyl-[acp] glucan family galactokinase: MtaB: mtaB [+ 3 isozymes] methylguanosine 2251 TilS: tilS matched hisD B: asnB proC 2-(S-geranyl) a proteinogenic stranded DNA phosphorylase: T513_RS0107400 DHAP a dipeptide in 23S rRNA DNA base pair asn arg thiouridine 34 in tRNA D-erythrose 3-oxoacyl-[acyl- glgP 6 acetaldehyde D-galactopyranose amino acid canavaninosuccinate (2E)-dec-2-enoyl-CoA a 2-methylsulfanyl-N -L- acyl-carrier protein an acyl phosphate gly 4-nitrophenol DHAP 34 his pro trp α-D-galactose 4-phosphate a lysidine carrier-protein] UDP-α-D-glucose 37 5'-deoxyadenosine an unsulfurated β-D-fructofuranose a glycoside threonylcarbamoyladenine met in tRNA Ile2 reductase: fabG an α-limit dextrin 1-phosphate [sulfur carrier] in tRNA a 5-methylaminomethyl- a (3R)-3- 4-alpha- 2-(Se-phospho) hydroxydecanoyl-[acp] glucanotransferase: (S)-3- 6 4 34 N -(3-methylbut- an O - 34 an [amino-group carrier (3R,5S)-3- selenouridine in tRNA a [protein]- a [protein]-S- a uridine a D-aminoacyl- an L-aspartyl- 3-hydroxyacyl- malQ hydroxydecanoyl-CoA coenzyme A [EntB aryl- a uracil in DNA a RNA-DNA hybrid γ NADH Nucleoside and Nucleotide Biosynthesis a sulfurated [sulfur carrier] 2-en-1-yl)- methylthymine sulfanyl-L-cysteine in tRNA protein]-C-terminal- - Asn met hydroxy-1- L-cysteine carrier protein] [tRNA] [tRNA ] ACP dehydratase [+ 2 isozymes] 3-hydroxyacyl-CoA adenosine 37 in tRNA in DNA (L-glutamyl)-L-glutamate Asp-tRNA(Asn) bifunctional pyrroline-5- FabZ: fabZ a debranched dehydrogenase: gluconeogenesis I Carbohydrate Biosynthesis acetylglutamate /Glu-tRNA(Gln) glutamate N- carboxylatepyrroline-5- superpathway of purine nucleotides de novo biosynthesis I a 5-methylaminomethyl- α-limit dextrin T513_RS0103670 tRNA 2- uracil-DNA NAD(+) UMP biosynthesis III superpathway of adenine and adenosine salvage III guanine and guanosine salvage superpathway of pyrimidine dTDP-β-L-rhamnose UDP-α-D-glucose methylated-DNA-- holo-ACP D-tyrosyl-tRNA(Tyr) ribonuclease HII: kinase: argB carboxylate 2-selenouridine 34 tRNA (N6-isopentenyl thiouridine(34) glycosylase: amidotransferase: acetyltransferase/ diphosphatase: guanosine nucleotides biosynthesis biosynthesis a (2E)-dec-2-enoyl-[acp] [protein]-cysteine S- synthase: T513_RS0103360 nucleobases salvage adenosine(37)-C2)- deacylase: an [amino-group carrier gatC gatA gatB amino-acid reductase: (S)-malate in tRNA glycogen/starch/ 3-oxodecanoyl-CoA synthase T513_RS0105495 nudC PRPP de novo biosynthesis I methyltransferase: acpS T513_RS0100590 an L-asparaginyl- proC uracil α-D-glucopyranose D-glucopyranose decanoyl-[acyl- methylthiotransferase MnmA: mnmA protein]-C-terminal- acetyltransferase gln adenine alpha-glucan T513_RS0106350 [tRNA Asn ] Hyp hydrogencarbonate guanosine uracil 1-phosphate 6-phosphate MiaB: miaB γ-(5-phospho-L- ArgJ: argJ amidophosphoribosyltransferase: phospho- carrier-protein] phosphorylase: reduced β- IMP purine-nucleoside purine-nucleoside glucose-1-phosphate D-glucopyranose an apyrimidinic uracil DNA a nucleoside 5'- N-acetyl-L- T513_RS0107640 phosphoribosyltransferase: upp reductase: fabG 3',5'-ADP a holo-[EntB aryl- glutamyl)-L-glutamate nicotinamide D- phosphorylase: deoD thymidylyltransferase sugar mutase: T513_RS0104500 a [protein]- a 2-thiouridine 34 an uncharged site in DNA monophosphate phosphorylase: deoD UMP tRNA processing 6 a [protein]-S- carrier protein] a D-amino acid methionine AMP amidophosphoribosyltransferase: carbamoyl T513_RS0110465 N -(3-methylbut-2-en- a thymine in DNA tRNA ribonucleotide purine-nucleoside malate RfbA: rfbA α-D-glucopyranose glycogen/ octanoyl-CoA an unsulfurated methyl-L-cysteine L-cysteine in tRNA T513_RS0105000 purine-nucleoside malate α a decanoyl-[acyl-carrier protein] 5'-deoxyadenosine 1-yl)-2-(methylsulfanyl) met phosphate synthase: IMP dehydrogenase: UMP kinase: dehydrogenase: malate dTDP- -D-glucose starch/alpha- phosphorylase: phosphorylase: 1-phosphate UDP-glucose-- 37 [sulfur carrier] β T513_RS0100625 T513_RS0101610 dehydrogenase, a polycistronic UDP-glucose adenosine in tRNA 5-phospho- - gly T513_RS0105005 T513_RS0105675 T513_RS0108015 dehydrogenase: dTDP-glucose 4,6- glucan family hexose-1-phosphate T513_RS0105675 NAD-requiring: UTP--glucose- beta-ketoacyl- tRNA precursor D-ribosylamine carB T513_RS0108015 4-epimerase adenosine guanine UDP dehydratase: rfbB ACP synthase phosphorylase: uridylyltransferase: T513_RS0108015 1-phosphate GalE: galE 6 [+ 2 isozymes] XMP dTDP-4-dehydro-6- glgP T513_RS0107395 an O - D-cellobiose (+)-7-epi- D-firefly a double-stranded a negatively an organic nucleoside- uridylyltransferase II: fabF methanethiol O-acetyl-L- a [protein]- coenzyme A [EntF L-seryl- carbamoyl H O H O an L-glutamyl- phosphoribosylamine- α α-D-glucopyranose (2E)-oct-2-enoyl-CoA methylguanine L-ornithine 2 2 xanthine deoxy- -D-glucopyranose α L-cysteine 6'-phosphate jasmonoyl-CoA luciferyl-CoA oligonucleotide Gln supercoiled DNA hydroperoxide -glycine ligase: purD adenosine diphosphate kinase: ndk GalU: galU UDP- -D-galactose homoserine carrier protein] phosphate [tRNA ] dITP carbamoyl a 3-oxododecanoyl-[acp] α-D- 1-phosphate in DNA bifunctional DNA thioredoxin- asp glutamine- phosphoribosyltransferase: oxaloacetate dTDP-4- Asp-tRNA(Asn) deaminase: add UTP a tRNA precursor a tRNA precursor glucopyranose oligoribonuclease/ topoisomerase RdgB/HAM1 family dependent phosphate hydrolyzing GMP T513_RS0103420 dehydrorhamnose UDP-α-D-glucose /Glu-tRNA(Gln) phospho- 6-phospho-beta- acyl-CoA acyl-CoA non-canonical CTP synthase: 3-oxoacyl-[acyl- with a 5' with a 5' 1-phosphate O-acetylhomoserine methylated-DNA-- holo-ACP ornithine PAP phosphatase IV: parE parC thiol GAR synthase: guaA hypoxanthine pyruvate UDP-N-acetyl-D- 3,5-epimerase: rfbC thioesterase: thioesterase: amidotransferase: phosphoenolpyruvate extension and extension and a sugar mutase: aminocarboxypropyltransferase/ [protein]-cysteine S- glucosidase: synthase: NrnA: purine NTP peroxidase: aspartate inosine T513_RS0106210 glucosamine biosynthesis I dTDP-4-dehydro- carrier-protein] (S)-3- carbamoyltransferase: gatC gatA gatB type I DNA phosphoribosyltransferase: hpt phospho- T513_RS0110465 lactose and galactose T513_RS0107170 T513_RS0105830 T513_RS0105830 pyrophosphatase: phosphoribosylglycinamide carboxykinase β reductase: fabG a long 3' trailer short 3' extension hydroxyoctanoyl-CoA cysteine synthase: methyltransferase: acpS argF T513_RS0103435 an L-glutaminyl- topoisomerase: bcp carbamoyltransferase GMP CTP -L-rhamnose formyltransferase: (ATP): pckA D-glucopyranose ribonuclease sugar mutase: degradation I T513_RS0105600 T513_RS0106350 [+ 3 isozymes] a nucleoside 5'- [tRNA Gln ] rdgB regulatory subunit: purine-nucleoside GMP dTDP-4- a (3R)-3- D-glucopyranose 3-hydroxyacyl-CoA topA an alcohol T513_RS0100290 6-phosphate P protein T513_RS0110465 lactose 6'- a holo-[EntF (+)-7-epi- monophosphate [+ 2 isozymes] T513_RS0107050 phosphorylase: deoD glucose-6- dehydrorhamnose UDP-α-D-galactofuranose hydroxydodecanoyl-[acp] 6-phosphate dehydrogenase: D-firefly luciferin a relaxed DNA guanylate component: 3',5'-ADP L-seryl-carrier jasmonate purine-nucleoside phosphoenol phosphate biosynthesis polyribonucleotide phosphate T513_RS0103670 a [protein]-S- D-glucopyranose dIMP FGAR aspartate guanine and guanosine salvage II reductase: rfbD 3-hydroxyacyl- D-glucopyranose acetate a guanine in DNA D-glucopyranose protein] L-citrulline kinase: gmk pyruvate nucleotidyltransferase: pnp rnpA met methyl-L-cysteine 6-phosphate carbamoyltransferase: phosphorylase: isomerase: 6-phospho-beta- dTDP-β-L-rhamnose ACP dehydratase a tRNA precursor 6-phosphate 3-oxooctanoyl-CoA T513_RS0105675 phosphopyruvate T513_RS0107660 UDP-α-D-glucose galactosidase: phosphoribosylformylglycinamidine pyrB FabZ: fabZ a tRNA with a short hydratase: eno F6P UDP-glucose 4- lacG synthase: T513_RS0100275 GDP guanosine precursor with 3' extension hypoxanthine epimerase GalE: galE D-galactopyranose adenine 2503 a uridine 34 a thiocarboxylated a long-linear a hypoxanthine dihomo γ- an oxidized a supercoiled N-carbamoyl- 2-phospho- glutamine-- UDP-α-D-galactose a (2E)-dodec-2-enoyl-[acp] a 5' extension coenzyme A AsbD acyl- α-D-glucopyranose H O an acyl-CoA H O acetyl-CoA FGAM 6-phosphate in 23S rRNA in tRNA [SAMP] C- α-D-glucan in DNA linolenoyl-CoA 2 2 L-homocysteine factor 420 duplex DNA L-aspartate D-glycerate fructose-6- sucrose degradation III (sucrose invertase) carrier protein XTP xanthine UDP-galactopyranose dodecanoyl-[acyl- ribonuclease terminal glycine acetyl-CoA Coenzyme F420 ATP- nucleoside- 2,3-bisphosphoglycerate- phosphate hexanoyl-CoA homocysteine S- phosphoribosylformylglycinamidine phosphoribosyltransferase: mutase: glf carboxylase biotin hydrogenase/ RdgB/HAM1 family dependent dihydroorotase: diphosphate guanine carrier-protein] P protein 23S rRNA 4-alpha- DNA-deoxyinosine acyl-CoA acyl-CoA cyclo-ligase: T513_RS0100295 independent transaminase sucrose tRNA 2- holo-ACP carboxylase subunit: methyltransferase: non-canonical DNA T513_RS0103420 reductase: fabG component: glucanotransferase: dehydrogenase, T513_RS0107655 kinase: ndk phosphoglycerate (isomerizing) UDP-Galf D-tagatofuranose (adenine(2503)-C(2) glycosylase: thioesterase: thioesterase: mmuM purine NTP fatty acid elongation -- saturated thiouridine(34) synthase: T513_RS0106320 beta subunit C- helicase hypoxanthine xanthine rnpA )-methyltransferase malQ T513_RS0106425 T513_RS0105830 T513_RS0105830 AIR dGDP mutase: : glmS 6-phosphate synthase acpS pyrophosphatase: RecG: recG (S)-dihydroorotate phosphoribosyltransferase: hpt phosphoribosyltransferase: a dodecanoyl-[acp] sucrose-6- [+ 3 isozymes] met terminal domain: T513_RS0106025 RlmN: rlmN [+ 2 isozymes] rdgB a single D-glucosamine tagatose-6- (2E)-hexenoyl-CoA MnmA: mnmA T513_RS0104075 5-(carboxyamino) T513_RS0103420 an uncharged phosphate malonyl-CoA GTP nucleoside- 3-phospho- 6-phosphate an acetoacetyl-[acp] phosphate an apurinic site di-homo-γ- a reduced [+ 2 isozymes] stranded DNA imidazole dihydroorotate IMP hypoxanthine tRNA hydrolase: a holo-[AsbD acyl- a carboxylate beta-ketoacyl- 2503 34 3',5'-ADP a short 1,4- factor 420 dehydrogenase diphosphate D-glycerate phosphoglucosamine T513_RS0106920 kinase: pfkA a 2-methyladenine a [SAMP] C- a 2-thiouridine carrier protein] within DNA hypoxanthine linolenate XMP ribonucleotide phosphoribosyltransferase: hpt 5'-deoxyadenosine α-D-glucan kinase: ndk phosphoglycerate mutase: ACP synthase D-tagatofuranose in 23S rRNA met mutase: purE electron [+ 3 isozymes] terminal glycine in tRNA pyrimidine deoxyribonucleotides kinase: T513_RS0108375 II: fabF 1,6-bisphosphate transfer subunit: (S)-3- asp de novo biosynthesis I GMP glycogen biosynthesis I (from ADP-D-Glucose) laurate CAIR T513_RS0102545 dGTP T513_RS0106135 α-D-glucosamine β-D-fructofuranose D-glucopyranose hydroxyhexanoyl-CoA 1-phosphate lipoprotein posttranslational UDP CTP a 3-oxoacyl-[acp] a nascent peptidoglycan a [protein]- a DNA methyl a long-chain a guanine 966 a cytidine 34 dihydroorotate a 3-oxotetradecanoyl-[acp] 3-hydroxyacyl-CoA coenzyme A an apo [peptidyl- stachyose a D-tryptophanyl- H O α-amylose an unfolded 13-DPG D-glucopyranose 6-phosphate modification 2 A ammonium H O (meso-DAP containing) L-cysteine phosphotriester Trp fatty acyl-CoA 2 in 16S rRNA in tRNA phosphoribosylaminoimidazolesuccinocarboxamide dehydrogenase: dehydrogenase: carrier protein] [tRNA ] ITP protein superpathway of D-glyceraldehyde 16S rRNA tRNA (cytidine(34) 1,4-alpha-glucan synthase: T513_RS0100300 T513_RS0102550 phospho- 3-oxoacyl-[acyl- a [prolipoprotein]- T513_RS0103670 adenosine nucleotides dUDP CDP type I DHAP branching RdgB/HAM1 family α lauroyl-CoA 3-oxoacyl- L-cysteine 3-phosphate endolytic (guanine(966)-N(2) -2'-O)- chaperonin PRPP N-acetyl- -D- sugar mutase: carrier-protein] D-glucopyranose methylated-DNA-- alpha-galactosidase: acyl-CoA orotate de novo biosynthesis I pyrimidine ribonucleosides salvage I glyceraldehyde- 3-oxohexanoyl-CoA holo-ACP hydroxylamine )-methyltransferase methyltransferase: protein GlgB: glgB non-canonical nucleoside- glucosamine T513_RS0110465 reductase: fabG [acyl-carrier- prolipoprotein 6-phosphate transglycosylase T513_RS0107415 D-tyrosyl-tRNA(Tyr) GroEL: groL SAICAR 3-phosphate [protein]-cysteine S- thioesterase: purine NTP diphosphate protein] synthase: reductase: hcp 2 RsmD: rsmD T513_RS0104370 1,4-alpha-glucan 1-phosphate α beta- diacylglyceryl MltG: mltG alpha-galactosidase: deacylase: T513_RS0105830 an N - a 2'-O- orotate IMP cytidine triose-phosphate dehydrogenase: -D-glucopyranose a (3R)-3- glucose-6- methyltransferase: acpS pyrophosphatase: asp kinase: ndk ketoacyl- reductase: T513_RS0100590 966 34 branching dCDP UDP-N- 1-phosphate transferase: T513_RS0106350 T513_RS0103085 methylguanine methylcytidine a protein adenylosuccinate phosphoribosyltransferase: isomerase: gap hydroxytetradecanoyl-[acp] phosphate protein GlgB: glgB rdgB acetylglucosamine ACP fabG T513_RS0105610 sucrose degradation I a mature peptidoglycan a nascent peptidoglycan in 16S rRNA in tRNA lyase: purB T513_RS0105055 dUTP nucleoside- uridine nucleoside T513_RS0106140 glucose-1-phosphate isomerase: melibiose degradation D-glyceraldehyde 3-hydroxyacyl- synthase a [prolipoprotein]- (sucrose phosphotransferase) a long-chain hydroxylamine amylopectin [+ 2 isozymes] kinase: udk DHAP pyrophosphorylase: a (3R)-3- with (L-alanyl-γ-D-glutamyl- (meso-DAP containing) 3',5'-ADP a holo [peptidyl- α-D- adenylosuccinate dUTP diphosphate deaminase: 3-phosphate adenylyltransferase: a 2,3,4-saturated T513_RS0107660 butanoyl-CoA a [protein]-S- fatty acid T513_RS0104235 ACP dehydratase II: fabF S-1,2-diacyl-sn- meso-2,6-diaminopimeloyl- with GlcNAc terminus carrier protein] raffinose D-tryptophan a tRNA Trp IMP AICAR kinase: ndk T513_RS0109330 T513_RS0105505 hydroxyacyl-[acyl- melibiose [DNA] galactopyranose orotidine 5'- synthase: diphosphatase: FabZ: fabZ fatty acyl-[acp] glyceryl-L-cysteine sucrose methyl-L-cysteine CMP UDP-N-acetyl- 3-hydroxyacyl-carrier protein] F6P D-alanine) tetrapeptide phosphate T513_RS0100005 T513_RS0104530 dCTP cytidine deaminase: glucose-1-phosphate phosphoribosylaminoimidazolecarboxamide α-D-glucosamine ACP T513_RS0107545 adenylyltransferase a (2E)-tetradec-2-enoyl-[acp] formyltransferase: T513_RS0106505 [+ 3 isozymes] class II signal alpha-galactosidase: orotidine-5'- dehydratase a ring-opened 7- an apo-[LYS2 L- 46 1498 subunit GlgD: glgD peptidase T513_RS0107415 β-D-fructofuranose a [release factor]- a guanine a uracil CTP phosphate adenylo-succinate dUMP fructose-1,6- FabZ: fabZ crotonyl-CoA D-glucopyranose maltohexaose coenzyme A raffinose FMN NAD(P)H H + DNA with lesion roseoflavin uridine myristoyl-[acyl- II: lspA sucrose 6 G methylguanine 2-aminoadipyl- 1-phosphate L-glutamine in tRNA in 16S rRNA FAICAR decarboxylase: bisphosphate α α alpha-galactosidase: anaerobic thymidylate a (1->4)- -D-glucan ADP- -D-glucose carrier-protein] -phosphate in DNA carrier-protein] peptide chain tRNA 16S rRNA excinuclease riboflavin adenylosuccinate uridine aldolase: fba chitobiose degradation T513_RS0103085 ribonucleoside- pyrF synthase: thyA reductase: fabG an (S-diacyl- release factor (guanosine(46)-N7) (uracil(1498)-N(3))- ABC subunit biosynthesis IMP cyclohydrolase: kinase: udk glycogen a lipoprotein 4-alpha- alpha-galactosidase: class II fructose- triphosphate lyase: purB holo-ACP flavin reductase: N(5)-glutamine -methyltransferase methyltransferase: UvrC: uvrC protein T513_RS0100285 UMP dTMP synthase sn-glyceryl) signal peptide sucrose-6- DNA- glucanotransferase: T513_RS0107415 UMP a myristoyl-[acp] enoyl-[acyl- N,N'-diacetylchitobiose D-galactopyranose D-glucopyranose (S)-3- T513_RS0103060 1,6-bisphosphate reductase: nrdD RibF: ribF a trans-2- -L-cysteinyl- formamidopyrimidine synthase: methyltransferase: 7 TrmB: trmB 3 T513_RS0102150 excinuclease GlgA: glgA carrier- 6'-phosphate phosphate malQ alpha-galactosidase: aldolase: fba an N - an N - dTMP kinase: β-D-fructose 1,6- a 2,3,4-saturated hydroxybutanoyl-CoA acpS flavin reductase: prmC ribonucleoside roseoflavin AMP enoyl-[acyl- [apolipoprotein] hydrolase: glycosylase: mutM methylguanine 46 methyluracil 1498 ABC: uvrA uvrB T513_RS0109345 a (1->4)-α-D-glucan beta-ketoacyl- fatty acyl-[acp] protein] [+ 2 isozymes] T513_RS0103085 T513_RS0110080 a [release factor]-N 5 DNA without 5'-phosphate IMP bisphosphate carrier protein] 3-hydroxyacyl-CoA triphosphate PRPP biosynthesis reductase: T513_RS0103475 in tRNA in 16S rRNA dTDP ACP synthase N-monoacetylchitobiose dehydrogenase: a holo-[LYS2 L- -methyl-L-glutamine lesion reductase: 1,4-alpha-glucan [+ 3 isozymes] a [DNA]- 2,6-diamino-4- DHAP D-glyceraldehyde adenylate kinase: adenine and II: fabF fabG a peptide 6'-phosphate a 5'-phospho- 3',5'-ADP 2-aminoadipyl- α-D- T513_RS0108970 D-ribose 5- T513_RS0103670 4-oxo-2-pentenal maltopentaose maltose sucrose nucleoside- adenosine salvage I branching an N-acyl-(S- fructose degradation nucleotide- [DNA] hydroxy-5-(N-methyl) galactopyranose FMNH NAD(P) + T513_RS0110775 6-phospho-beta- carrier-protein] 2 phosphate β-D-glucose 3'-phosphate formamidopyrimidine dCTP diphosphate ribose-phosphate protein GlgB: glgB a 3-oxohexadecanoyl-[acp] diacyl-sn-glyceryl) β-D-fructofuranose acetoacetyl-CoA IMP dehydrogenase: F6P 2,3,4-saturated glucosidase: 6-phosphate ADP kinase: ndk pyrophosphokinase: 1,4-alpha-glucan -L-cysteinyl- β-D-fructofuranose T513_RS0100625 adenosine fatty acyl- T513_RS0107170 branching 3-oxoacyl-[acyl- [lipoprotein] 1-phosphate a 7,8-dihydro- 37 superpathway of pyrimidine deoxyribonucleoside salvage dTTP glucose-6- T513_RS0103835 [+ 3 isozymes] guanine a double UTP D-ribulose purine-nucleoside carrier-protein] [acp]:NAD+ 1-phosphofructokinase: D-glucopyranose a maltodextrin coenzyme A an apo-[aryl- melibionate NADP + FMNH canavaninosuccinate a holo [PedN acyl- L,L- phosphate PRPP protein GlgB: glgB 8-oxoguanine 2 in tRNA Phe stranded DNA 5-phosphate phosphorylase: deoD reductase: fabG oxidoreductase: N-acetyl-D-glucosamine pfkB carrier protein] carrier protein] diaminopimelate anaerobic 2'-deoxycytidine isomerase: β-D-fructose 1,6- in DNA tRNA DNA: ribulose- purine-nucleoside a glycogen fabG 6-phosphate F6P acetyl-CoA ACP S- diaminopimelate ribonucleoside- T513_RS0107660 a (3R)-3- bisphosphate (guanosine(37)-N1) gyrA gyrB phosphate 3- XMP phosphorylase: queuosine biosynthesis I (de novo) 4-alpha- alpha-galactosidase: flavin reductase: malonyltransferase: epimerase: triphosphate nucleoside 2'-deoxycytidine D-glucopyranose hydroxyhexadecanoyl-[acp] Cell Structure Biosynthesis DNA- holo-ACP argininosuccinate -methyltransferase DNA epimerase: dADP T513_RS0105675 glucanotransferase: T513_RS0107415 T513_RS0110080 reductase: nrdD deaminase: kinase: synthase: lyase: argH fabD TrmD: trmD T513_RS0111070 topoisomerase rpe adenine 6-phosphate 3-hydroxyacyl- formamidopyrimidine malQ alpha-galactosidase: a malonyl[PedN an N 1 - glutamine- T513_RS0110035 acpS flavin reductase: meso- ribonucleoside D-xylulose T513_RS0109330 preQ glycosylase: mutM 37 IV: parE parC nucleoside- ACP dehydratase peptidoglycan biosynthesis I (meso-diaminopimelate containing) 0 [+ 2 isozymes] T513_RS0103085 acyl-carrier methylguanine hydrolyzing T513_RS0103060 diaminopimelate a negatively triphosphate 5-phosphate cytidine deaminase: NADPH-dependent 7- Phe GMP asp diphosphate adenine FabZ: fabZ protein] in tRNA dCMP cyano-7-deazaguanine Inorganic Nutrient supercoiled DNA reductase: T513_RS0107545 kinase: ndk UDP-N-acetyl-α-D-glucosamine a [DNA]- a holo-[aryl- L-canavanine fumarate synthase: phosphoribosyltransferase: Metabolism a 5'-phospho- 7,8-dihydro- 3',5'-ADP α-D- T513_RS0108970 reductase QueF: queF 4-oxo-2-pentenal a maltodextrin maltose D-gluconate guaA adenylosuccinate (d)CMP kinase: T513_RS0102045 a (2E)-hexadec-2-enoyl-[acp] nucleotide- [DNA] 8-oxoguanine carrier protein] galactopyranose FMN NADPH H + UDP-N-acetylglucosamine preQ dUTP 2'-deoxyuridine T513_RS0100725 1 3'-phosphate synthase: dATP 1-carboxyvinyltransferase: urea cycle palmitoyl-[acyl- Amino Acid Degradation GMP T513_RS0100005 dCDP AMP T513_RS0110545 thymidine kinase: carrier-protein] tRNA guanosine(34) UDP-N-acetyl- UDP-N-acetyl-α-D- transglycosylase Tgt: tgt decaprenyl-diphospho-N- a 2,3,4-saturated a DNA containing (S)-2,3,4,5- a guanine 37 a [protein]-L- D-sedoheptulose D-ribose 5- adenylo-succinate T513_RS0109715 nucleoside- reductase: fabG L-threonine degradation I arg α D-glucopyranose maltopentaose FMN NADH H + a holo [PedD acyl- glucosamine-enolpyruvate -D-glucosamine acetylmuramoyl-pentapeptide 1,2-diacyl-sn- an apurinic/ tetrahydrodipicolinate proline (ω = 180) 1-phosphate phosphate guanylate deoxynucleoside diphosphate a 7-aminomethyl-7- L-citrulline degradation L-glutamine carrier protein] in tRNA GTP thymidine glycerol 3-phosphate CTP apyrimidinic site 2,3,4,5- tRNA peptidylprolyl ribose 5- a palmitoyl-[acp] 34 degradation I kinase: gmk adenylosuccinate kinase: kinase: ndk UDP-N-acetylmuramate deazaguanosine in tRNA ACP S- undecaprenyldiphospho- tetrahydropyridine- (guanosine(37)-N1) isomerase: phosphate lyase: purB T513_RS0110035 dehydrogenase: murB thr 4-alpha- diguanylate cyclase: class II thymidine kinase: dCTP purine deoxyribonucleosides salvage tRNA preQ1(34) S- argininosuccinate flavin reductase: 2,6-dicarboxylate N- malonyltransferase: -methyltransferase T513_RS0107715 isomerase threonine L-citrulline muramoylpentapeptide beta-N- glucanotransferase: phosphatidate T513_RS0103935 T513_RS0109715 UDP-N-acetylmuramate adenosylmethionine gln lyase: argH endonuclease T513_RS0110080 fabD fructose-1,6- GDP ornithine ammonium acetylglucosaminyltransferase: acetyltransferase: 1 TrmD: trmD [+ 3 isozymes] B: rpiB ammonia-lyase: carbamoylphosphate malQ cytidylyltransferase: a malonyl- an N - [+ 2 isozymes] dUMP deoxynucleoside acyl-CoA hydrolysis dehydrogenase: murB ribosyltransferase- III: nth flavin reductase: dapD a [protein]-L- bisphosphate D-ribulose AMP ala carbamoyltransferase: murG T513_RS0101585 37 glu isomerase QueA: queA (2Z)-2-aminobut-T513_RS0108425 synthase large subunit: [+ 2 isozymes] [PedD acyl- methylguanine proline (ω = 0) c-di-GMP aldolase: fba 5-phosphate kinase: 2'-deoxyguanosine 2'-deoxyadenosine UDP-N-acetyl-α-D-muramate argF carbamoylphosphate T513_RS0103060 L-2-acetamido-6- xanthine and palmitate carbamoyl T513_RS0103655 L-arginino- carrier protein] in tRNA T513_RS0110035 deoxynucleoside deoxynucleoside a 2,3,4-saturated 2-enoate L-ornithine synthase large subunit: oxoheptanedioate thymidylate xanthosine salvage an epoxyqueuosine 34 in tRNA phosphate succinate decaprenyl-pyrophosphoryl- a 3'-terminal a 5'-phospho- adenylate kinase: kinase: kinase: fatty acyl CoA [+ 10 isozymes] T513_RS0103655 UDP a CDP-2,3,4-saturated- synthase: thyA acyl-CoA glutamate UDP-N-acetylmuramate- maltose maltotetraose D-erythrose T513_RS0110775 glu (N-acetylglucosamine)-N- diacylglycerol unsaturated sugar [DNA] FMNH NAD + DHAP nucleoside- T513_RS0110035 T513_RS0110035 racemase: murI -alanine ligase: carbamoylphosphate [+ 2 isozymes] 2 thioesterase: epoxyqueuosine acetylmuramyl-(pentapeptide) diphosphate dGMP dAMP xanthosine T513_RS0105830 T513_RS0102085 reductase QueH: synthase large subunit: ADP carbamoyl kinase: ndk a 2,3,4-saturated 2-iminobutanoate T513_RS0103655 ornithine CMP purine-nucleoside palmitoyl-CoA D-glt T513_RS0103730 phosphate fatty acid argininosuccinate 10 a (1->4)- phosphorylation UDP-N-acetyl-α-D-muramoyl-L-alanine [+ 2 isozymes] carbamoyltransferase: an L-methionyl- an N - a [DNA]-3'- γ-glutamyl- phosphoenol phosphorylase: deoD 34 synthase: D-glucopyranose maltotetraose maltotriose a glucan α a holo [BryU acyl- D-threo-isocitrate (R)-lactate a queuosine in tRNA argF Met a type IV prepilin -D-glucan L-homoserine [initiator tRNA ] formyltetrahydrofolate hydroxyl carrier protein] isopropylamide pyruvate dGDP CMP purine-nucleoside carbamate T513_RS0106380 NADP-dependent D-2-hydroxyacid UDP-N-acetylmuramoyl- L-alanine L-citrulline dTMP (d)CMP kinase: phosphorylase: ACP S- homoserine O- isocitrate ferredoxin: dehydrogenase: pyruvate L-alanine--D- 4-alpha- 4-alpha- maltodextrin GTP T513_RS0100725 T513_RS0105675 degradation IV malonyltransferase: succinyltransferase: T513_RS0100735 kinase: pyk dADP dGDP dADP 2-oxobutanoate methionyl-tRNA exodeoxyribonuclease dehydrogenase: T513_RS0108525 dTMP kinase: CDP xanthine glutamate ligase: murD glucanotransferase: glucanotransferase: glucosidase: III: xth prepilin peptidase: fabD metA T513_RS0103520 nucleoside- T513_RS0109345 6 37 L-glutamine formyltransferase: malQ malQ T513_RS0101070 a malonyl- N-(γ-L-glutamyl) D-2-hydroxyacid α N -L-threonylcarbamoyladenosine 2-ketobutyrate ala T513_RS0101810 pyruvate diphosphate nucleoside- nucleoside- nucleoside- nucleoside- xanthine meso-diaminopimelate UDP-N-acetyl- -D-muramoyl- T513_RS0107080 O-succinyl-L- 2-oxoglutarate dehydrogenase: dTDP -modified tRNA biosynthesis formate- CO degradation II [+ 2 isozymes] [+ 2 isozymes] [BryU acyl- -L-alaninol kinase: ndk diphosphate phosphoribosyltransferase: L-alanyl-D-glutamate 2 alanine homoserine T513_RS0100770 diphosphate diphosphate diphosphate lyase: pflB C1 Compound Utilization a 2'- a (1->4)- carrier protein] kinase: ndk T513_RS0103420 a [DNA]-3'- D-glucopyranose kinase: ndk nucleoside- kinase: ndk kinase: ndk dehydrogenase: ald and Assimilation an N-formyl- deoxyribonucleoside α-D-glucan pyruvate UDP-N-acetylmuramoyl- thr gln hydroxyl a cleaved type diphosphate CTP propanoyl-CoA pyruvate L-methionyl- a tetrahydrofolate maltose maltotriose a glucan D-glucopyranose 5'-monophosphate a peptide L-alanyl-D-glutamate-- glutamate IV prepilin kinase: ndk threonylcarbamoyl- formate assimilation into 5,10- met dGTP dATP dGTP dATP XMP synthase large [initiator tRNA ] 2, 6-diaminopimelate AMP synthase: phosphate methylenetetrahydrofolate dTTP subunit: gltB ligase: T513_RS0102165 T513_RS0107375 propanoyltransferase: D-ala (L-threonylcarbamoyl) T513_RS0110900 NADPH- UDP-N-acetyl-α-D-glucosamine undecaprenyl-diphospho-N a plant soluble a single- adenine 37 Cofactor, Carrier, and Vitamin Biosynthesis UDP-N-acetylmuramoyl- adenylate formate D-glucopyranose coenzyme A coenzyme A [DNA] a holo [BryP acyl- acetate (S)-malate pullulan dependent -acetylmuramoyl-L-alanyl-γ- heteroglycan stranded RNA VibB in tRNA val a protein L-alanyl-D-glutamate-- tRNA (adenosine(37)-N6)- propanoyl formate-- carrier protein] 1 D-alanine--D- glutamate D-glutamyl-L-lysyl- D-alanine DNA polymerase tRNA1(Val) type I 2, 6-diaminopimelate tetrahydrofolate endopeptidase alanine ligase: threonylcarbamoyltransferase phosphate ACP S- acetate kinase: fumarate hydratase: [2Fe-2S] iron-sulfur synthase: gltA undecaprenyldiphospho- IV: dinB (adenine(37)-N6)- La: lon pullulanase: flavin biosynthesis I (bacteria and plants) superpathway of pyridoxal 5'-phosphate biosynthesis and salvage NAD de novo biosynthesis ligase: T513_RS0110220 complex: tsaD tsaB tsaE ligase: 4-alpha- cluster biosynthesis bis(guanylyl molybdopterin) tetrahydrofolate biosynthesis thiamine diphosphate T513_RS0106080 glu polyribonucleotide CoA pyrophosphatase: holo-ACP DNA polymerase malonyltransferase: methyltransferase: T513_RS0103440 T513_RS0110930 pulA 6 acetate kinase: T513_RS0100310 muramoylpentapeptide beta-N- glucanotransferase: endopeptidase I (from aspartate) cofactor sulfurylation biosynthesis I (E. coli) an N -L- an N 10 - fabD α nucleotidyltransferase: pnp T513_RS0107595 synthase: III subunit 6 T513_RS0109440 D-erythrose (7,8-dihydropterin- UDP-N-acetyl- -D-muramoyl-L-alanyl- D-alanyl-D-alanine 37 T513_RS0103440 acetylglucosaminyltransferase: malQ a malonyl- an N - La: lon maltotriose threonylcarbamoyladenine formyltetrahydrofolate acetyl phosphate fumarate 2-[(2R,5Z)- γ acpS gamma/tau: dnaX 37 L-cysteine desulfurase 4-phosphate 6-yl)methyl -D-glutamyl-meso-2,6-diaminopimelate in tRNA murG [+ 2 isozymes] [BryP acyl- methyladenine a peptide GTP asp cys 4-aminobenzoate 2-carboxy-4- propanoate bifunctional a 2'-deoxyribonucleoside diphosphate carrier protein] in tRNA val a single- 1 cysteine L-aspartate oxidase: methylthiazol-5(2H UDP-N-acetylmuramoyl- methylenetetrahydrofolate ditrans,octacis-undecaprenyldiphospho- a nucleoside 4'-phosphopantetheine 5'-monophosphate UDP a plant soluble 3',5'-ADP 3',5'-ADP a holo-[VibB aryl- desulfurase: bifunctional cysteine )-ylidene]ethyl tripeptide--D-alanyl- dehydrogenase/ diphosphate stranded RNA T513_RS0103510 HMP-PP N-acetyl-(N-acetylglucosaminyl)muramoyl- maltose carrier protein] Alcohol Degradation heteroglycan T513_RS0100540 3,4-dihydroxy- 4-phospho- 2-iminosuccinate desulfurase: phosphate D- alanine ligase: Fermentation methenyltetrahydrofolate L-alanyl-γ-D-glutamyl-L-lysyl-D-alanine cysteine 2-butanone- D-erythronate T513_RS0100540 T513_RS0106075 cyclohydrolase FolD: folD quinolinate 7,8- desulfurase: 4-phosphate cysteine thiamine phosphate ethanol dihydropteroate pyruvate fermentation ethylene glycol a 5,10- a [formate C a single RNase R degradation (5Z,8Z,11Z,14Z,17Z) an N-terminal L- a guanine 527 a 2'- uridine synthase/GTP synthase synthase: UDP-N-acetyl-α-D-muramoyl-L- degradation I glycerol degradation V glycerol degradation II a ribonucleoside a single T513_RS0103215 desulfurase: to ethanol I methenyltetrahydrofolate a reduced flavodoxin SAM alanyl-[S18 protein thr ferulate a protein NadA: nadA folylpolyglutamate alanyl-γ-D-glutamyl-meso-2,6- di-trans,octa-cis-undecaprenyl phosphate degradation acetyltransferase]-glycine stranded DNA substrate RNA -icosapentaenoyl-CoA triphosphate in 16S rRNA deoxyribonucleoside cyclohydrolase II: T513_RS0103215 T513_RS0110295 stranded DNA of 30S ribosome] an S-sulfanyl-[L- (3R)-3-hydroxy-2-oxo- synthase/ bifunctional ribosomal protein 16S rRNA deoxynucleoside phenolic acid ATP- uridine T513_RS0103620 an [L-cysteine diaminopimeloyl-D-alanyl-D-alanine ethanol glycerol glycerol threonine quinolinate thiamine pyruvate methylenetetrahydrofolate (guanine(527)-N(7) kinase: udk cysteine desulfurase] 2,5-diamino-6- 4 phosphooxybutanoate desulfurase]-S- dihydrofolate ethylene glycol glycerol glycerol acyl-CoA S18-alanine N- kinase: decarboxylase: dependent zinc phosphate bifunctional pyruvate formate DNA ammonia-lyase: (5-phospho-D- 3-phosphoserine/ D-glyceraldehyde synthase: phospho-N- lactaldehyde dehydrogenase/ exodeoxyribonuclease ribonuclease acetyltransferase: )-methyltransferase T513_RS0110035 T513_RS0109475 metalloprotease pyruvate carboxylating sulfanyl-L-cysteine acetaldehyde- dehydrogenase: dehydrogenase: lyase-activating thioesterase: T513_RS0108425 UMP synthase: methenyltetrahydrofolate VII: xseB xseA R: rnr primase: 7 RsmG: rsmG a 2'- ribosylamino) phosphohydroxythreonine 3-phosphate cysteine T513_RS0102200 acetylmuramoyl- formate C- reductase: fucO T513_RS0102940 T513_RS0102940 T513_RS0105830 an N-terminal N-acetyl-rimI an N - FtsH: ftsH nicotinate- thiE CoA/alcohol protein: pflA dnaG 4-vinylguaiacol glycolaldehyde cyclohydrolase FolD: folD 527 deoxyribonucleoside 2-oxobutanoate pyrimidin- transaminase: serC desulfurase: 7,8-dihydrofolate pentapeptide- acetyltransferase: dehydrogenase: dihydroxyacetone dihydroxyacetone L-alanyl-[S18 protein methylguanine a peptide nucleotide 5'-monophosphate an S-sulfanyl-[cysteine 4(3H)-one 1-deoxy-D-xylulose- T513_RS0100540 transferase: pflB a 5,10- of 30S ribosome] in 16S rRNA 4-phosphooxy- diphosphorylase: monoglutamate adhE glycolaldehyde a single-stranded desulfurase]-[disordered- 5-phosphate bis(guanylyl thiamine a [formate C acetyltransferase]- a ribonucleoside a diribonucleotide a nucleoside 5'- (5Z,8Z,11Z,14Z,17Z) L-threonine cysteine T513_RS0110990 acetaldehyde methylenetetrahydrofolate 5'-deoxyadenosine coenzyme A ssDNA/pppN(pN) nadC dehydrogenase: a flavodoxin semiquinone glycin -2-yl radical met 5'-monophosphate oligodeoxyribonucleotide monophosphate -icosapentaenoate form scaffold synthase: molybdopterin) phosphate hybrid desulfurase: acetyl-CoA formate T513_RS0109580 n -1 protein] complex T513_RS0101360 cofactor thiamine diphosphate undecaprenyldiphospho- bifunctional [cysteine desulfurase]-S- 5-amino-6-(5- NaMN T513_RS0103215 DHAP DHAP Detoxification D-ribulose biosynthesis III N-acetylmuramoyl-L-alanyl- acetaldehyde- sulfanylcysteine:[acceptor phospho-D- a [bis(guanylyl a 7,8-dihydrofolate bifunctional glycolate 3-amino-1- 1-deoxy-D- pyridoxine nicotinate-nucleotide γ-D-glutamyl-meso-2,6- α undecaprenyl-diphospho-N-acetylmuramoyl-L- α a (1->4)- 1518 5-phosphate molybdopterin) (Staphylococcus) CoA/alcohol UDP-N-acetyl- -D-glucosamine 7,8-dihydrofolate + 2-O-( -D- adenine / an insertion sequence 3-(imidazol- cytidine protein]-cysteine ribosylamino)uracil acetaldehyde- NADPH H sucrose a nucleoside reduced riboflavin trans-caffeate hydroxyacetone xylulose 5- adenylyltransferase: thiamine diaminopimeloyl-D-alanyl-D-alanine 8-oxo-(d)GTP detoxification I alanyl-γ-D-glutamyl-L-lysyl- D-alanyl-D-alanine α-D-glucan 1519 [bis-MGD cofactor cofactor dihydrofolate CoA/alcohol dehydrogenase: monoglutamate glucopyranosyl)glycerol triphosphate adenine in 16S rRNA element IS30 5-yl)lactate ATP sulfurtransferase: bifunctional 1-phosphate phosphate pyridoxamine HMP-PP T513_RS0101235 reductase: diphosphate undecaprenyldiphospho- adhE nucleotide ribosomal RNA transposase: flavin reductase: phenolic acid L-lactate uridine T513_RS0100540 3,4-dihydroxy- pyridoxamine chaperone]- chaperone]-S- thiamine phosphate dehydrogenase: pyruvate undecaprenyldiphospho- pyrophosphohydrolase: small subunit T513_RS0103060 kinase: udk a [cysteine desulfurase]- kinase: pyridoxamine nicotinate adenine bis-MGD sulfanyl-L-cysteine T513_RS0100145 synthase: muramoylpentapeptide beta-N- adhE muramoylpentapeptide beta-N- T513_RS0108535 decarboxylase: dehydrogenase: diadenylate 5-amino-6-(5- 2-butanone- fermentation acetyl-CoA dihydrofolate accessory Sec system amylosucrase: S-sulfanyl-[disordered- kinase: dinucleotide acetylglucosaminyltransferase: dGTP GTP T513_RS0102415 methyltransferase flavin reductase: T513_RS0109475 T513_RS0100155 cyclase CdaA: 4-phosphate T513_RS0109205 T513_RS0110295 to (S)-lactate acetylglucosaminyltransferase: reductase: glycosyltransferase T513_RS0103895 [+ 31 isozymes] phospho-D- a tetrahydrofolate A: rsmA an insertion T513_RS0110080 CMP form scaffold synthase/GTP T513_RS0109205 NAD + murG acetaldehyde Carboxylate Degradation murG T513_RS0100145 GtfA: gtfA nucleotide N 6 -dimethyladenine 1518 3,4- 3-(imidazol- T513_RS0108385 ribitylamino)uracil pyridoxal coenzyme A biosynthesis thiamine protein] complex pyruvate pyrophosphohydrolase: 6 1519 sequence IS30 with riboflavin cyclohydrolase II: pyridoxine pyridoxamine synthetase, NAD(+) /N -dimethyladenine dihydroxystyrene 5-yl)pyruvate c-di-AMP cysteine I (prokaryotic) phosphate lipid II (meso diaminopimelate containing) bifunctional L-lactate integrated transposon T513_RS0103620 glutamine synthase: sulfo-bis(guanylyl 8-oxo-dGTP 8-oxo-GTP a (1->4)- T513_RS0109975 in 16S rRNA desulfurase: 5'-phosphate 5'-phosphate synthase: acetaldehyde- dehydrogenase: bile acids deconjugation ditrans,octacis-undecaprenyldiphospho-N- α-D-glucopyranose D-fructofuranose pyridoxamine molybdopterin) UDP 5,6,7,8- + glycerol α-D-glucan a nucleoside 5'- 1-deoxy-L- dependent: nadE (R)-4'- NADP T513_RS0100540 thiE CoA/alcohol T513_RS0100155 8-oxo-dGTP acetyl-(N-acetyl-β-D-glucosaminyl)muramoyl-L- tetrahydrofolate 1-phosphate monophosphate kinase: nadE cofactor phosphopantothenate thiamine glycero-tetrulose bifunctional (S)-lactate diphosphatase: alanyl-γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine cysteine ARP T513_RS0109205 tetrahydrofolate salvage from dehydrogenase: glycocholate glycochenodeoxycholate 4-phosphate phosphate + phosphopantothenoylcysteine 5,10-methenyltetrahydrofolate adhE taurocholate taurochenodeoxycholate T513_RS0107590 desulfurase: NAD tauroursodeoxycholate decarboxylase/ 8-oxo-GMP T513_RS0103215 6,7-dimethyl-8- a peptidoglycan a cytidine 1402 D-mannopyranose (2R,3S)-3- an S-sulfanyl-[cysteine thioredoxin PLP phosphopantothenate-- a 5,10- ethanol choloylglycine choloylglycine 8-oxo-dGMP UDP-N-acetyl-α-D-muramoyl- F6P a uridine in tRNA histidinol thiazole component of thiamine diphosphate biosynthesis I D-alanyl-D-alanine fumarate asp dimer (generic) (R)-pantothenate 4-coumarate ribityllumazine methenyltetrahydrofolate hydrolase: bsh hydrolase: bsh L-alanyl-γ-D-glutamyl-L-lysine in 16S rRNA 6-phosphate isopropylmalate desulfurase]-S- pathway (R)-4'- cysteine ligase CoaBC: coaBC bifunctional synthase: S-adenosyl-L-methionine salvage I tRNA-dihydrouridine 16S rRNA type III class I mannose- 3-isopropylmalate phenolic acid histidinol sulfanyl-[disordered- thiamine phosphopantothenoyl- methylenetetrahydrofolate NADPH repair (prokaryotes) synthase: (cytidine(1402)-2'-O) pantothenate 6-phosphate form scaffold T513_RS0103615 an oxidized fructose-6- endolytic dehydrogenase: decarboxylase: dehydrogenase: cys L-cysteine dehydrogenase/ ursodeoxycholate cholate chenodeoxycholate UDP-N-acetylmuramoyl- T513_RS0108500 -methyltransferase: kinase: isomerase: protein] complex thioredoxin thiamine L-aspartate oxidase: phosphate aldolase: transglycosylase leuB T513_RS0109475 hisD SAH bifunctional methenyltetrahydrofolate tripeptide--D-alanyl- T513_RS0108010 [cysteine desulfurase]-S- 6,7-dimethyl-8-(1- diphosphokinase: NADPH T513_RS0103510 tRNA dihydrouridine MltG: mltG rsmI T513_RS0101955 4-methyl-2- cysteine D- alanine ligase: T513_RS0107780 a 2'-O- (R)-4'- sulfanylcysteine:[acceptor phosphopantothenoylcysteine 10 cyclohydrolase FolD: folD 4-vinylphenol his D-ribityl)lumazine an N - T513_RS0101695 synthase DusB: dusB methylcytidine 1402 F6P oxopentanoate protein]-cysteine desulfurase: 5'-methylthioadenosine/ decarboxylase/ T513_RS0106075 phosphopantothenate riboflavin thioredoxin- formyltetrahydrofolate a 5,6-dihydrouridine in tRNA GlcNAc-1,6- in 16S rRNA T513_RS0100540 adenosylhomocysteine thiamine D-glyceraldehyde sulfurtransferase: phosphopantothenate-- 2-iminosuccinate succinate dihydroxyacetone a lipid II synthase: disulfide phosphoribosylglycinamide diphosphate anhydro-MurNAc- T513_RS0100540 cysteine nucleosidase: cysteine ligase CoaBC: coaBC UDP-N-acetyl-α-D-muramoyl-L-alanyl- 3-phosphate a [cysteine ribE reductase: formyltransferase: pentapeptide desulfurase: T513_RS0101250 γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine desulfurase]-(S- trxB 4'-phosphopantetheine T513_RS0100290 (R)-NADPHX riboflavin T513_RS0103215 bifunctional sulfanyl) -[disordered- S-ribosyl-L-homocysteine 2 an [L-cysteine ADP-dependent an [amino-group carrier protein]- form scaffold pantetheine- a tetrahydrofolate a purine base D-glyceraldehyde D-sedoheptulose a 5S rRNA a cytidine 1402 (2R,3S)-3- (R)-propane- riboflavin desulfurase]-S- NAD(P)H-hydrate γ palmitoleoyl-CoA H O meso- a DNA segment lesion in DNA 3-phosphate 7-phosphate C-terminal- -(L-glutamate 5- 2 an acyl phosphate protein] complex sulfanyl-L-cysteine a reduced phosphate precursor in 16S rRNA diaminopimelate isopropylmalate 1,2-diol biosynthesis thiamine diphosphate salvage II dehydratase/ semialdehyde-2-yl)-L-glutamate 16S rRNA cysteine a [ThiS sulfur- thioredoxin S-ribosylhomocysteine adenylyltransferase: N-acetyl-gamma- 3-isopropylmalate protein NAD(P)H-hydrate (cytosine(1402)-N(4) diaminopimelate acylphosphatase: lactaldehyde recombinase desulfurase: carrier protein] 4-amino-2-methyl-5- lyase: T513_RS0106905 coaD DNA- glutamyl-phosphate acyl-CoA dehydratase: RibF: ribF epimerase: ribonuclease )-methyltransferase dehydrogenase: T513_RS0107880 reductase: fucO RecA: recA T513_RS0100540 pyrimidinemethanol 3'-dephospho- formamidopyrimidine transketolase: tkt reductase: thioesterase: leuC leuD a [cysteine desulfurase]- sulfur carrier T513_RS0101750 M5: rnmV RsmH: rsmH T513_RS0111150 a DNA segment FMN an [amino-group carrierT513_RS0106370 protein]- an N 4 - (2S)-2- [scaffold protein- cysteine protein ThiS bifunctional AI-2 CoA folate transformations III (E. coli) (S)-NADPHX glycosylase: mutM T513_RS0105830 (S)-2,3,4,5- (R)-lactaldehyde L-homocysteine 1402 a carboxylate in reverse dephospho- C-terminal-γ-(5-phospho- methylcytidine tetrahydrodipicolinate isopropylmalate (2Fe-2S)] complex desulfurase: adenylyltransferase: hydroxymethylpyrimidine orientation riboflavin L-glutamyl)-L-glutamate in 16S rRNA T513_RS0103215 thiF kinase/ CoA kinase: bifunctional a [DNA]- D-ribose 5- D-xylulose a double-stranded biosynthesis 5-methyltetrahydropteroyltriglutamate- a tetrahydrofolate a 5'-phospho- a modified a mature 5S-rRNA a [ThiI sulfur- a carboxy- T513_RS0100110 ADP-dependent nucleotide- 4-oxo-2-pentenal phosphate 5-phosphate oligonucleotide palmitoleate protein phosphomethylpyrimidine - homocysteine S-methyltransferase: [DNA] nucleobase carrier protein]-S- adenylated-[ThiS kinase: thiD NAD(P)H-hydrate 3'-phosphate a [co-chaperone]- RibF: ribF T513_RS0106810 sulfanyl-L-cysteine sulfur-carrier protein] coenzyme A cobalamin- dehydratase/ [scaffold protein- cobalamin-dependent FAD D-glyceraldehyde HMP-P dependent NAD(P)H-hydrate (2Fe-2S)] complex methionine synthase: an [HPr]- phosphoenol D-xylulose D-erythrose a pseudouridine 1915 a 6-phospho- a cytosine 967 GDP-α-D- carboxy-adenylated- 3-phosphate methionine synthase: epimerase: seleno-L- citrate a folate D-glycerate N5-CAIR SSQ1 tyr 5-(2-hydroxyethyl) bifunctional T513_RS0110585 dihydrofolate L-histidine pyruvate 5-phosphate 4-phosphate in 23S rRNA β-D-galactoside in 16S rRNA mannose [ThiS sulfur- T513_RS0110585 T513_RS0101750 homocysteine chaperone: 1-deoxy-D-xylulose- -4-methylthiazole hydroxymethylpyrimidine reductase: 23S rRNA 16S rRNA dihydrofolate GDP-mannose 5-(carboxyamino) carrier-protein] 5-methyltetrahydropteroyltriglutamate- dnaK 5-phosphate 2-iminoacetate met T513_RS0100145serine (pseudouridine(1915)- (cytosine(967)-C(5) aconitate hydratase: 4,6-dehydratase: glycerate kinase: imidazole sulfurtransferase: thiI hydroxyethylthiazole kinase/ NADPH phosphoenolpyruvate- 6-phospho-beta- reductase: a [chaperone-ATP]- synthase: synthase a 7,8-dihydrofolatehydroxymethyltransferase:a 5-methyltetrahydrofolate - homocysteine S-methyltransferase: N(3))-methyltransferase )-methyltransferase T513_RS0108755 T513_RS0102915 T513_RS0100340 ribonucleotide di-trans,poly-cis kinase: thiM phosphomethylpyrimidine -protein transketolase: tkt galactosidase: T513_RS0100145 [co-chaperone]- ThiH: thiH methionine T513_RS0107365 T513_RS0106810 GDP-4-dehydro- a thiocarboxylated- T513_RS0101360 kinase: thiD 3 RlmH: rlmH lacG RsmB: rsmB mutase: purE -undecaprenyl phosphotransferase: ptsP an N - 967 2-phospho- [scaffold protein- 4-methyl-5-(2- adenosyltransferase: a 5-methylcytosine D-threo-isocitrate a 7,8-dihydrofolate α-D-rhamnose [ThiS sulfur- 1-deoxy-D-xylulose thymidylate a (6S)-5-formyltetrahydrofolate SeMet methylpseudouridine 1915 D-glycerate CAIR (2Fe-2S)] complex phosphate biosynthesis 2-iminoacetate phosphooxyethyl) T513_RS0100485 in 16S rRNA carrier protein] 5-phosphate HMP-PP bifunctional (2E,6E)-farnesyl thiazole synthase: thyA an [HPr protein]- D-glyceraldehyde in 23S rRNA D-galactopyranose IPP methylenetetrahydrofolate5-formyltetrahydrofolate NADH repair (prokaryotes) π F6P an alcohol SSQ1 diphosphate SAM N -phospho- pyruvate 3-phosphate 6-phosphate thiazole synthase: dehydrogenase/ cyclo-ligase: ATP biosynthesis chaperone thiamine phosphate methylenetetrahydrofolate L-histidine methenyltetrahydrofolate T513_RS0110285 T513_RS0107685 NADH ATPase: dnaK isoprenyl synthase: NAD salvage pathway I (PNC VI cycle) reductase [NAD(P)H]: metF cyclohydrolase FolD: folD ADP T513_RS0110295 thiamine diphosphate 6 transferase: 2-[(2R,5Z)-2-carboxy- a 5,10-methylenetetrahydrofolate a 5,10-methenyltetrahydrofolate an N -L- 34 a 3,5,7,9,11,13,15- 55 a [chaperone- V-type ATP synthase: 5-amino-4- a 5-carboxymethylaminomethyluridine a single α a uridine 2'-deoxycytidine a large- T513_RS0101590 4-methylthiazol-5(2H)- thiamine biosynthesis + PRPP 37 an -limit dextrin a cytosine in DNA D-ribofuranose an [2Fe-2S] NADP NAD T513_RS0105885 imidazolecarboxyamide threonylcarbamoyladenine Leu hepta-oxo- branched glucan ADP]-[disordered- II (Bacillus) bifunctional in tRNA stranded DNA in tRNA deoxynucleoside cluster protein ylidene]ethyl phosphate phosphate in tRNA tRNA (cytidine(34) hexadecanoyl-[PKS-acp] 4-alpha- form scaffold biosynthesis T513_RS0105895 aldo/keto reductase: tRNA type I di-trans,octa-cis synthase: thiE methylenetetrahydrofolate tRNA deoxyribonuclease glucanotransferase: DNA methylase: kinase: ribokinase: HMP-PP NAD + synthetase, T513_RS0105900 -2'-O)- T513_RS0107135 pullulanase: protein] complex -undecaprenyl NAD(+) dehydrogenase/ (R)-NADHX adenine pseudouridine(55) T513_RS0110035 T513_RS0105400 NAD + thiamine phosphate threonylcarbamoyladenosine methyltransferase: IV: T513_RS0107615 malQ T513_RS0107985 non- glutamine diphosphatase: T513_RS0105905 aldo/keto reductase: synthase TruB: truB pulA diphosphate cytidylyl molybdenum methenyltetrahydrofolate bifunctional phosphoribosyltransferase: dehydratase: T513_RS0101690 dCMP NAD kinase: synthase: dependent: nadE NAD(+) T513_RS0105910 6 T513_RS0104370 [+ 2 isozymes] 55 D-ribofuranose a long-linear chaperonin undecaprenyl- thiamine phosphate nudC 4-aminobenzoate cyclohydrolase FolD: folD ADP-dependent T513_RS0102045 a cyclic N -L- 9-hydroxy-3,5,7,11,13,15-T513_RS0102740 a α-limit dextrin a pseudouridine a 5-methylcytosine folate polyglutamylation T513_RS0110295 cofactor sulfurylation a 5-carboxymethylaminomethyl- a 5'-phosphooligonucleotide α-D-glucan molecular T513_RS0107480 synthase: nadE biosynthesis T513_RS0105915 threonylcarbamoyladenosine in tRNA in DNA 5-phosphate diphosphate NAD(P)H-hydrate 2'-O-methyluridine 34 in tRNA Leu hexaoxohexadecanoyl- with short branches + thiamine an N 10 -formyltetrahydrofolate chaperone phosphatase: NADP nicotinate adenine dinucleotide NMN cytidylyl molybdenum dehydratase/ F0F1 ATP synthase: 37 in tRNA [PKS-acp] a tetrahydrofolate phosphate ATPase: dnaK T513_RS0103355 cofactor (trioxo) chorismate NAD(P)H-hydrate atpC atpD atpG AICAR synthase: an [Fe-S cluster di-trans,octa-cis nicotinate-nucleotide aminodeoxychorismate/ epimerase: T513_RS0107330 biosynthesis -undecaprenyl thiamine diphosphate thiE anthranilate synthase formate-- folylpolyglutamate serine thiamine adenylyltransferase: an [MCD cofactor T513_RS0101750 T513_RS0107335 atpF chaperone]-ATP phosphate component II: (S)-NADHX tetrahydrofolate synthase/ hydroxymethyltransferase: phosphate T513_RS0101235 chaperone]-MCD atpE T513_RS0107350 T513_RS0105150 ligase: dihydrofolate T513_RS0107365 cysteine 4-amino-4- bifunctional ATP T513_RS0100310 synthase: NaMN nicotinamide desulfurase: deoxychorismate ADP-dependent T513_RS0102200 a 5,10- T513_RS0100540 NAD(P)H-hydrate thiamine acyl carrier an N 10 - methylenetetrahydrofolate thiamine cysteine dehydratase/ diphosphate protein formyltetrahydrofolate folylpolyglutamate diphosphate desulfurase: NAD(P)H-hydrate salvage III a tetrahydrofolate nicotinate activation folylpolyglutamate synthase/ phosphoribosyltransferase: T513_RS0103215 4-aminobenzoate epimerase: an apo acyl- thiamine synthase/ dihydrofolate T513_RS0109515 a [cytidylyl molybdenum T513_RS0101750 carrier protein thiamine dihydrofolate synthase: nicotinate cofactor chaperone]- holo-ACP diphosphokinase: synthase: T513_RS0102200 cytidylyl molybdenum NADH synthase: T513_RS0101695 T513_RS0102200 cofactor (sulfo-dioxo) acpS thiamine a 5,10- a holo acyl- diphosphate an N 10 - methylenetetrahydrofolate carrier protein formyltetrahydrofolate an L-sorbose 1-phosphate a branched- D-fructose 1-phosphate chain an amino an amino an amino a dicarboxylate D-mannose 6-phosphate amino acid a sugar 6- a sugar 6- a sugar 6- acid acid acid an L-sorbose 1-phosphate an L-sorbose 1-phosphate phosphate phosphate phosphate an amino an amino a sugar 6- a sugar 6- a sugar 6- a sugar 6- a sugar 6- a sugar 6- a sugar 6- a sugar 6- D-fructose D-fructose 1-phosphate D-mannose D-fructose 1-phosphate D-glucose 6- chromate chromate (S)-lactate queuosine ammonium phosphate phosphate phosphate phosphate phosphate phosphate phosphate phosphate acid acid 1-phosphate 6-phosphate a carbohydrate phosphate D-mannose 6-phosphate D-mannose 6-phosphate predicted predicted predicted predicted predicted PEP-driven ABC predicted predicted predicted ABC ABC ABC transporter transporter PEP-driven PEP-driven PEP-driven ManX RS0101270 RS0109120 RS0110665 RS0105250 RS0101920 RS0101660 RS0100950 transporter transporter transporter RS0105320 RS0108980 RS0100965 RS0100970 RS0108815 RS0108930 RS0108945 RS0108800 of D- RS0107825 of a RS0110715 RS0107420 Amt RS0108855 transporter transporter transporter of an of an of an mannose/ branched- of a sugar of a sugar of a sugar amino acid amino acid amino acid D-fructose/ chain L-sorbose amino acid queuosine ammonium

L-sorbose L-sorbose L-sorbose a branched- a sugar a sugar a sugar a sugar a sugar a sugar a sugar a sugar a sugar a sugar a sugar an amino an amino an amino an amino D-fructose D-mannose a carbohydrate D-glucose chromate chromate D-fructose D-fructose D-fructose (S)-lactate chain acid acid acid acid a dicarboxylatean amino D-mannose D-mannose D-mannose amino acid acid This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.