Authors: Pallavi Subhraveti Peter D Karp Ingrid Keseler An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane are shown on the membrane. Anamika Kothari Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000442315Cyc: Rubellimicrobium thermophilum DSM 16684 Cellular Overview Connections between pathways are omitted for legibility. Ron Caspi

II (meso phosphate diaminopimelate sn-glycerol containing) phosphate dCTP 3-phosphate predicted ABC RS07495 RS12165 RS03605 transporter RS13105 of phosphate lipid II (meso dCTP sn-glycerol diaminopimelate phosphate 3-phosphate containing) phosphate

Secondary Metabolite Degradation Storage Compound Biosynthesis Tetrapyrrole Biosynthesis Hormone Biosynthesis Aromatic Compound Aldehyde Degradation UDP-N-acetyl- Biosynthesis undecaprenyl- a mature (4R)-4-hydroxy- an L-glutamyl- a []-L- queuosine at Macromolecule Modification myo-inositol degradation I α-D-glucosamine adenosylcobinamide a purine L-canavanine 5'-deoxyadenosine sec Metabolic Regulator Biosynthesis Amine and Polyamine Biosynthesis polyhydroxybutanoate biosynthesis siroheme biosynthesis methylglyoxal degradation I diphospho-N- peptidoglycan 2-oxoglutarate Gln β-isoaspartate glu position 34 ser a tRNA indole-3-acetate 4-deoxy-L-threo-hex-4- D-fructuronate degradation L-idonate ribonucleoside (n) [tRNA ] ATP roseoflavin chorismate biosynthesis I acetylmuramoyl- (meso-DAP protein-L- of a tRNA Asp enopyranuronate degradation degradation Asp-tRNA(Asn) 5'-phosphate Aminoacyl-tRNA Charging glutaminyl-tRNA gln biosynthesis via transamidation biosynthesis tRNA-uridine 2-thiolation and selenation (bacteria) L-alanyl-γ-D- 5'-triphosphate containing) isoaspartate O- ppGpp spermidine biosynthesis III acetyl-CoA uroporphyrinogen-III myo-inositol S-methyl-5'- /Glu-tRNA(Gln) trehalose biosynthesis I putrescine spermidine biosynthesis I IV (bacteria) D-erythrose 4-deoxy-L-threo-hex- D-fructuronate methylglyoxal glutamyl-L-lysyl- Arginase/agmatinase/ bifunctional methyltransferase: trehalose siroheme synthase: (indole-3-yl) 4-enopyranuronate L-idonate lactoylglutathione : bifunctional formimionoglutamate thioadenosine 4-hydroxy-2- amidotransferase tRNA glutamyl- - biosynthesis I acetyl-CoA C- 4-phosphate inositol 2- D-alanyl-D-alanine RUTHE_RS00520 bifunctional glu biosynthesis V RUTHE_RS00605 acetonitrile cys D-mannonate L-idonate 5- RUTHE_RS06270 UDP-N- adenosylcobinamide lytic : oxoglutarate subunit GatB: gatB Q(34) synthetase -tRNA pppGpp D-glucopyranose arg SAM acyltransferase: dehydrogenase: protein-L- riboflavin / UDP-α-D-glucose SAM uroporphyrinogen-III : dehydrogenase: acetylglucosamine- kinase/ transglycosylase arginase family: mtnP aldolase/2- Asp-tRNA(Asn) GluQRS: : a glycogen 6-phosphate RUTHE_RS13365 3-deoxy- iolG lactoylglutathione lyase: isoaspartate(D- FAD synthetase: bifunctional (p)ppGpp arg C-methyltransferase: RUTHE_RS11770 RUTHE_RS11800 -N-acetylmuramyl- adenosylcobinamide- domain-containing RUTHE_RS02820 dehydro-3-deoxy- /Glu-tRNA(Gln) RUTHE_RS04050 serS isoamylase: (indol-3-yl) D-arabino- 5-dehydro-4-deoxy- 5-dehydro- RUTHE_RS06595 aspartate) O- RUTHE_RS03210 synthetase/guanosine- [+ 2 isozymes] cobA scyllo-inosose (R)-S-lactoylglutathione (pentapeptide) phosphate protein: phosphogluconate amidotransferase guanosine 3'- glgX trehalose-6- acetamide heptulosonate D-glucuronate D-mannonate D-gluconate arginase: rocF α methyltransferase: 3',5'-bis(diphosphate) 3'- precorrin-1 pyrophosphoryl- : RUTHE_RS01915 5-deoxy- -ribose aldolase: eda subunit GatC: gatC glutamyl- diphosphate 5'- a maltodextrin phosphate acetoacetyl-CoA 7-phosphate adenine RUTHE_RS00315 roseoflavin an L-seryl- an L-glutamyl- pyrophosphohydrolase: agmatine amidase: an [L-cysteine desulfurase]- myo-inosose-2 5-dehydro- mannonate hydroxyacylglutathione undecaprenol N- cobU [+ 5 isozymes] 1-phosphate an L-glutaminyl- a protein L-β- queuosine at triphosphate 3'- synthase: 3-dehydroquinate Gln [tRNA sec ] Gln agmatine dAdoMet uroporphyrinogen-III RUTHE_RS08370 S-sulfanyl-L-cysteine dehydratase: iolE 4-deoxy-D- acetylglucosamine [tRNA ] adenine [tRNA ] RUTHE_RS04610 diphosphatase: malto- RUTHE_RS07565 putrescine dAdoMet synthase: dehydratase: D-galactonate degradation hydrolase: gloB urea isoaspartate position 34 Arginase/agmatinase/ C-methyltransferase: glucuronate adenosyl- L-canaline Asp dinucleotide oligosyltrehalose 3D-(3,5/4)- uxuA : a mature GlcNAc-1,6- glyoxylate pyruvate α-methyl ester of a tRNA Asp-tRNA(Asn) RUTHE_RS04610 formimionoglutamate cobA (indol-3-yl)acetate RUTHE_RS04375 : D-gluconate cobinamide synthase: treY α,α-trehalose polyamine trihydroxycyclohexane- (R)-lactate ditrans,octacisRUTHE_RS03610- UDP a purine peptidoglycan anhMurNAc- /Glu-tRNA(Gln) hydrolase polyamine (3R)-3- kduI 2-dehydro-3- D-galactonate phosphate (n) gln aminopropyltransferase: 3-dehydroquinate 1,2-dione : undecaprenyldiphospho- (meso-DAP L-Ala-γ-D-Glu- amidotransferase a maltooligosyl- 6-phosphate arginase family: aminopropyltransferase: hydroxybutanoyl- poly-[(R)-3- precorrin-2 a [TusA sulfur-carrier protein]- deoxy-D-gluconate ribonucleoside speE 3D-(3,5/4)- 3-deoxy-D-glycero- D-galactonate RUTHE_RS10490 N-acetyl-(N-acetyl-β-D- containing) DAP-D-Ala subunit GatB: gatB GTP ppGpp trehalose trehalose- RUTHE_RS02820 speE CoA hydroxybutanoate] type II 3- S-sulfanyl-L-cysteine 5'-diphosphate Asp-tRNA(Asn) siroheme synthase: trihydroxycyclohexane- 2,5-hexodiulosonate dehydratase: D-gluconate glucosaminyl)muramoyl- Asp-tRNA(Asn) malto- phosphatase: 1 dehydroquinate /Glu-tRNA(Gln) N -(3- [+ 2 isozymes] class I poly(R)- RUTHE_RS00605 1,2-dione acylhydrolase 2-dehydro- RUTHE_RS02350 6-phosphate L-alanyl-γ-D-glutamyl-L- /Glu-tRNA(Gln) oligosyltrehalose otsB aminopropyl) dehydratase: aroQ pyruvate a reduced amidotransferase nucleoside- bifunctional (p)ppGpp putrescine spermidine hydroxyalkanoic (decyclizing): iolD 3-deoxy-D- 2-dehydro-3-deoxy- lysyl-D-alanyl-D-alanine amidotransferase trehalohydrolase: α α agmatine KDGP H O c-type subunit GatB: gatB diphosphate kinase: synthetase/guanosine- , -trehalose acid synthase: sirohydrochlorin 3-dehydroshikimate a [TusD sulfur-carrier protein]- gluconate 5- D-galactonate 2 cytochrome- subunit GatC: gatC treZ 5-deoxy-D-glucuronate cytochrome [+ 3 isozymes] RUTHE_RS14460 3',5'-bis(diphosphate) 3'- phaC S-sulfanyl-L-cysteine dehydrogenase 2-dehydro-3- c oxidase, an oxidized a 5-phosphooxy- UDP-N-acetyl- undecaprenyldiphospho- a DNA containing UDP-N-acetyl- phosphoenol pyrophosphohydrolase: α,α-trehalose siroheme synthase: shikimate 5- KduD: kduD a nucleoside an L-aspartyl- oleoyl-CoA H O 34 O cbb3-type c-type L-glutamyl- bifunctional deoxygalactonokinase: D-sorbitol degradation I α-D-glucosamine N-acetylmuramoyl-L- an apurinic/ α D-glt H O 3'-AMP ala 2 a cytidine lys 2 ammonium a ribonucleic acid -D-muramoyl- 2 Asn pyruvate UDP-N-acetyl- Gln RUTHE_RS04610 poly-[(R)-3- RUTHE_RS00605 dehydrogenase: triphosphate GTP [tRNA ] dGDP Ile2 acytochrome reduced [tRNA ] 2-dehydro-3- 4-hydroxy-2- RUTHE_RS08865 alanyl-γ-D-glutamyl-meso apyrimidinic site L-alanine α-D-muramate in tRNA spermidine hydroxybutanoate] RUTHE_RS12865 2-dehydro-3-deoxy- Asp-tRNA(Asn) 5'/3'-nucleotidase H O c-type siroheme a [TusE sulfur carrier 5-dehydro-2- deoxy-D-gluconate oxoglutarate D-sorbitol -2,6-diaminopimeloyl- SurE: surE 2 cytochrome Asp-tRNA(Asn) a uridine 34 in tRNA D-galactonate /Glu-tRNA(Gln) tol-pal system- ancytochrome oxidized shikimate protein]-S-sulfanylcysteine deoxy-D-gluconate aldolase/2- L-iditol 2- D-alanyl-D-alanine endonuclease DNA- tRNA c oxidase /Glu-tRNA(Gln) GDP 6-phosphate UDP-N- GTPase amidotransferase bifunctional 2',3'- UDP-N- associated O c-type dehydro-3-deoxy- directed RNA 2 5-dehydro-2- dehydrogenase: III: nth acetylmuramoyl- HflX: hflX subunit GatB: gatB pyruvate cyclic-nucleotide 2'- acetylmuramate-- acyl-CoA lysidine(34) a reduced amidotransferase : phosphogluconate UDP-N- : cytochrome tRNA 2-thiouridine(34) deoxygluconokinase: 2-dehydro-3-deoxy-6- RUTHE_RS10505 bifunctional DNA- L-alanine--D- [+ 2 isozymes] Asp-tRNA(Asn) kinase: pyk phosphodiesterase/ L-alanine ligase: thioesterase: synthetase H O c-type subunit GatB: gatB RUTHE_RS04380 aldolase: eda keto-D-fructose acetylglucosamine- rpoB rpoC 2 synthase MnmA: mnmA iolC KDGP phosphogalactonate formamidopyrimidine glutamate ligase: /Glu-tRNA(Gln) 3'-nucleotidase: RUTHE_RS03615 ybgC TilS: tilS cytochrome Asp-tRNA(Asn) -N-acetylmuramyl- RS12765 an oxidized shikimate 3- 5-dehydro-2-deoxy-D- aldolase: glycosylase/ DNA-directed RUTHE_RS06155 amidotransferase RUTHE_RS11010 /Glu-tRNA(Gln) D-glyceraldehyde (pentapeptide) phosphate H + O c-type phosphate a 2-thiouridine 34 in tRNA gluconate 6-phosphate pyruvate RUTHE_RS08860 DNA-(apurinic RNA polymerase GDP subunit GatC: gatC pyruvate UDP-N-acetyl- a lysidine 34 2 amidotransferase bifunctional 3-phosphate pyrophosphoryl- an L-asparaginyl- dGTP adenosine H + RS00710 cytochromeH + 3-phosphoshikimate 1- or apyrimidinic subunit alpha: UDP-N-acetyl- α-D-muramoyl- oleate in tRNA Ile2 subunit GatC: gatC 4-hydroxy-2- undecaprenol N- Asn tRNA uridine-5- D-glyceraldehyde β-D-fructofuranose site) lyase: mutM RUTHE_RS11235 α-D-muramoyl-L- [tRNA ] L-alanine carboxyvinyltransferase: oxoglutarate pyruvate acetylglucosamine carboxymethylaminomethyl(34) 3-phosphate alanyl-D-glutamate aroA aldolase/2- : transferase: an L-glutaminyl- tRNA charging 5-enolpyruvoyl- synthesis GTPase MnmE: mnmE F0F1 ATP Gln DHAP dehydro-3-deoxy- RUTHE_RS03095 RUTHE_RS03610 a 3'-terminal a 5'-phospho- + + [tRNA ] shikimate 3- tRNA uridine-5- 3-oxopropanoate D-arabitol a ribonucleic acid H synthase H phosphate phosphogluconate degradation unsaturated sugar [DNA] carboxymethylaminomethyl(34) malonate F6P lipid II (meso glu a tRNA glu chorismate aldolase: eda UDP synthesis MnmG: mnmG semialdehyde D-arabinitol diaminopimelate containing) synthase: a 5-carboxymethylaminomethyl- dehydrogenase: D-glyceraldehyde ATP ser a tRNA ser phe a tRNA Phe tRNA asp asp aroC 34 + + glutamate-- elongator 2-thiouridine in tRNA RUTHE_RS05050 3-phosphate pyruvate H synthase F0 H gly a tRNA Gly his a tRNA His cys a tRNA Cys tyr a tRNA Tyr thr a tRNA Thr arg a tRNA Arg met initiator tRNA Met met ile a tRNA Ile trp a tRNA Trp leu a tRNA Leu a peptidoglycan a nascent peptidoglycan a [DNA]-3'- a 5'-phospho- sn-glycero-3- N-acetyl-D- phosphoenol (E)-4-hydroxy-3- tRNA Met D-xylulose NAD + lauroyl-CoA H O N-acetyl- subcomplex tRNA ligase: Lys Pro Val chorismate γ γ glu a (6S)-5- phospho-N- galactosamine a tRNA precursor 3'-GMP 2 methylbut-2-en- lys a tRNA pro a tRNA val a tRNA acetyl-CoA with (L-alanyl- -D- with (L-alanyl- -D- hydroxyl [DNA] dADP pyruvate L-citrulline Ala Asn Gln RUTHE_RS04935 formyltetrahydrofolate a tRNA ala asn tRNA gln a tRNA serine- phenylalanine- aspartate- : glutamyl-meso-2,6- glutamyl-meso-2,6- (arachidonoyl) 6-phosphate 5'/3'-nucleotidase 1-yl diphosphateflavodoxin- glycine--tRNA ligase: -tRNA glutamate-- histidine-- cysteine-- tyrosine-- threonine- arginine-- -tRNA ligase methionine-- methionine-- isoleucine-- tryptophan- leucine-- -tRNA Detoxification diaminopimeloyl-D- diaminopimeloyl-D- ethanolamine SurE: surE arsenite RS04810 arsenite a 5-aminomethyl-2-thiouridine 34 in tRNA xylB ATP-dependent tol-pal system- dependent RUTHE_RS01265 ligase: tRNA ligase: lysine--tRNA ligase: tRNA ligase: tRNA ligase: tRNA ligase: proline--tRNA ligase: -tRNA tRNA ligase: subunit tRNA ligase: tRNA ligase: tRNA ligase: -tRNA valine--tRNA ligase: tRNA ligase: ligase: alanine) tetrapeptide alanine) tetrapeptide xylulokinase: DNA ligase: bifunctional N-acetylglucosamine- ribonuclease D: bifunctional 2',3'- associated (E)-4-hydroxy- acetylornithine RUTHE_RS01275 serS RUTHE_RS06780 RUTHE_RS05115 RUTHE_RS05335 RUTHE_RS05625 RUTHE_RS05645 RUTHE_RS06355 ligase: thrS RUTHE_RS07365 alpha: pheS RUTHE_RS08145 RUTHE_RS08145 RUTHE_RS09310 ligase: trpS RUTHE_RS11830 RUTHE_RS14285 aspS xylB arsenate folylpolyglutamate glycerophosphoryl 6-phosphate RUTHE_RS01560 pyruvate cyclic-nucleotide 2'- 3-methylbut- deacetylase: 8-oxo-(d)GTP detoxification I superoxide RUTHE_RS06935 acyl-CoA detoxification L,D-transpeptidase: synthase/ diester deacetylase: ribonuclease kinase: pyk phosphodiesterase/ 2-enyl- argE a sugar RS12180 a sugar an L-methionyl- D-xylulose radicals degradation NAD- thioesterase: an L-alanyl- an L-asparaginyl- an L-glutaminyl- an L-seryl- an L-glutamyl- an L-lysyl- an L-histidyl- an L-cysteinyl- an L-tyrosyl- an L-prolyl- an L-threonyl- an L-arginyl- an L-phenylalanyl- an L-methionyl- an L-isoleucyl- an L-tryptophanyl- an L-valyl- an L-leucyl- an L-aspartyl- II (glutaredoxin) RUTHE_RS15740 dihydrofolate phosphodiesterase: RUTHE_RS08655 D: rnd 3'-nucleotidase: diphosphate a glycyl-[tRNA Gly ] [elongator a 5-methylaminomethyl- 5-phosphate dependent ybgC [tRNA Ala ] [tRNA Asn ] [tRNA Gln ] [tRNA ser ] [tRNA Glu ] [tRNA Lys ] [tRNA His ] [tRNA Cys ] [tRNA Tyr ] [tRNA Pro ] [tRNA Thr ] [tRNA Arg ] [tRNA Phe ] [initiator tRNA Met ] [tRNA Ile ] [tRNA Trp ] [tRNA Val ] [tRNA Leu ] [tRNA asp ] synthase: RUTHE_RS08535 RUTHE_RS11010 synthase: ispG tRNA Met ] 2-thiouridine 34 in tRNA arsenate dGTP GTP superoxide [+ 5 isozymes] DNA ligase 2-C-methyl-D- RUTHE_RS14320 acetate L-citrulline arsenate superoxide LigA: ligA D-galactosamine a nucleoside 5'- pyruvate erythritol-2,4- a sugar RS00115 a sugar tRNA 2-selenouridine(34) a nascent peptidoglycan acetate 6-phosphate a tRNA dATP guanosine laurate cyclodiphosphate synthase MnmH: mnmH reductase ArsC: dismutase: anandamide sn-glycerol monophosphate and Lipid Degradation with L,D cross links D-ala RUTHE_RS06940 8-oxo-dGTP 8-oxo-GTP hydrogenRUTHE_RS02320 a (6S)-5- 3-phosphate a 5-methylaminomethyl-2-(S- arsenite (meso-diaminopimelate peroxide [DNA] NMN formyltetrahydrofolate geranyl)thiouridine 34 in tRNA oleate β-oxidation 8-oxo-dGTP containing) AMP a sugar RS00405 a sugar fatty acid β-oxidation I (generic) tRNA 2-selenouridine(34) diphosphatase , Carrier, and Vitamin Biosynthesis cob(II)yrinate a,c-diamide superpathway of heme b synthase MnmH: mnmH MutT: mutT superpathway of heme b flavin biosynthesis I NAD de novo biosynthesis superpathway of adenosylcobalamin salvage from cobinamide I pyridoxal 5'-phosphate biosynthesis I oleate a (3Z)-alk-3- biosynthesis II (late biosynthesis from glycine 8-oxo-GMP a sugar RS00590 a sugar biosynthesis from glutamate (bacteria and plants) II (from tryptophan) Cell Structure Biosynthesis a 5-methylaminomethyl-2-(Se- enoyl-CoA arsenite 8-oxo-dGMP O a ring-opened 7- DNA with adenine:7,8- an N-terminal- a peptide with (R)-4-hydroxy- cobalt incorporation) D-erythrose acyl-CoA 2 H O a ribonucleoside a single a ribonucleoside an L-asparaginyl- palmitoyl-CoA H O an acyl-CoA H O 34 methylguanine diphosphate 2 dihydro-8- L-methionyl-L- 2 2 an N-terminal 4-methyl-2- cob(II)inamide phospho)selenouridine in tRNA triphosphate 3'-phosphate [tRNA Asn ] uroporphyrinogen-III glu gly 4-phosphate synthetase: in DNA stranded DNA oxoguanine mismatch cysteinyl-[protein] L-methionine oxoglutarate GTP trp lipid IV biosynthesis (P. putida) tRNA 2-selenouridine(34) RUTHE_RS04825 bifunctional 2',3'- 4-carboxy-4- siroheme synthase: glutamate-- A lipid IV biosynthesis (E. coli) Kdo transfer to a sugar RS00740 a sugar cob(I)yrinic acid a,c-diamide A synthase MnmH: mnmH cyclic-nucleotide 2'- hydroxy-2- RUTHE_RS00605 tRNA ligase: lipid IV I (E. coli) a (2E)-2- RdgB/HAM1 family non- tol-pal system- tol-pal system- adenosyltransferase: cobO a (3R)-3- A oleoyl-CoA bifunctional DNA- bifunctional A/G-specific type I methionyl phosphodiesterase/ aminoacyl-tRNA type I methionyl oxoadipate uroporphyrinogen-III GTP a (3R)-3- a 5-methylaminomethyl-2- associated associated RUTHE_RS04935 N-Formyl-L- 5-aminolevulinate 4-phospho- hydroxydecanoyl- UDP-N-acetyl- enoyl-CoA formamidopyrimidine canonical purine NTP DNA / adenine aminopeptidase: 3'-nucleotidase: hydrolase: aminopeptidase: aldolase/ cyclohydrolase hydroxytetradecanoyl- UDP-N-acetyl- CMP-Kdo lipid IV (E. coli) selenouridine 34 in tRNA acyl-CoA acyl-CoA C-methyltransferase: glutamate-- kynurenine [corrinoid adenosyltranferase]-cob(II)inamide D-erythronate [acp] α-D-glucosamine A acyl-CoA pyrophosphatase: rdgB polymerase: glycosylase: map RUTHE_RS02580 map II: ribA [acp] α a 2,3,4-saturated acyl-CoA enoyl-CoA glycosylase/ RUTHE_RS11010 thioesterase: thioesterase: oxaloacetate a sugar RS15020 a sugar cobA tRNA ligase: 2,5-diamino-6- porphobilinogen -D-glucosamine dehydrogenase: manganese- RUTHE_RS01060 RUTHE_RS00960 erythronate- fatty acid dehydrogenase: hydratase: a 2,3,4- DNA-(apurinic 5'/3'- ybgC ybgC decarboxylase: precorrin-1 RUTHE_RS06780 (5-phospho-D- synthase: hemB acyl-ACP--UDP-N- 3-deoxy-D-manno- RUTHE_RS13510 acyl-CoA dependent inorganic an L-glutamyl- 4-phosphate thiamine diphosphate salvage II acyl-ACP--UDP-N- RUTHE_RS12760 caiD saturated (3R)-3- or apyrimidinic DNA primase: an N-terminal L- nucleotidase ligK acetylglucosamine O- octulosonic acid [+ 3 isozymes] synthetase: Asn uroporphyrinogen-III Glu ribosylamino) dehydrogenase: site) lyase: mutM pyrophosphatase: RUTHE_RS03135 met asn tRNA met a peptide [tRNA ] porphobilinogen acyltransferase: lpxA acetylglucosamine O- transferase: tRNA processing RUTHE_RS04825[+ 3 isozymes] a 2,3,4- hydroxyacyl-CoA an apurinic site cysteinyl-[protein] SurE: surE pyruvate a sugar RS12705 a sugar C-methyltransferase: pyrimidin- L-kynurenine RUTHE_RS07020 4-amino-2-methyl-5- (2E,9Z)- a 2,3,4-saturated RUTHE_RS03220 [corrinoid adenosyltranferase]-cob(I)inamide acyltransferase: lpxA RUTHE_RS05240 saturated (3S)-3- Degradation adenine within DNA a ribonucleoside palmitate a carboxylate cobA 4(3H)-one pyrimidinemethanol octadecenoyl-CoA fatty acyl CoA 2,6-diamino-4- hydroxymethylbilane (3R)-3-hydroxy-2-oxo- UDP-3-O-[(3R)-3- a polycistronic hydroxyacyl-CoA a 5'-phospho- a 3'-phospho- ssDNA/pppN(pN) 4 phosphooxybutanoate bifunctional UDP-3-O-[(3R)-3- α enoyl-CoA hydroxy-5-(N-methyl) 4-oxo-2-pentenal hybrid cob(I)yrinic acid a,c-diamide synthase: hemC hydroxydecanoyl]- -Kdo-(2->6)- tRNA precursor acetyl-CoA C- [DNA] [DNA] + n -1 precorrin-2 hydroxymyristoyl]-N- hydratase: glycerophosphodiester formamidopyrimidine phosphate H (S)-4-amino-5- adenosyltransferase: cobO phosphoserine hydroxymethylpyrimidine N-acetyl-α-D- lipid IV (E. coli) acyltransferase: glycerol degradation V predicted acetyl-α-D-glucosamine A caiD degradation precorrin-2 (C 20 )- oxopentanoate 5-amino-6-(5- preuroporphyrinogen transaminase: kinase/ glucosamine ABC 3-hydroxy- UDP-3-O-acyl-N- KDO transferase: coenzyme A RUTHE_RS13365 a sugar a sugar methyltransferase: phospho-D- adenosylcobinamide RUTHE_RS07015 phosphomethylpyrimidine UDP-3-O-acyl-N- (S)-3-hydroxy-(9Z) transporter L-kynurenine acetylglucosamine RUTHE_RS05240 a 2,3,4-saturated acetyl-CoA C- a 2,3,4-saturated a glycerophosphodiester glycerol cobA ribosylamino)uracil D-ribulose D-glyceraldehyde kinase: thiD acetylglucosamine -octadecenoyl-CoA N-succinyl- 4-hydroxy- of a sugar pyruvate 4-phosphooxy- α glycerol + a D-tyrosyl- L-gulono- 5-phosphate bifunctional deacetylase: -Kdo-(2->4)- a tRNA precursor a tRNA precursor fatty acyl CoA acyltransferase: 3-oxoacyl-CoA glycerophosphoryl 34 menadione NADH H H O Ala stearoyl-CoA H O NADH 3-phosphate a 5,10-gly a uridine 2 L,L-2,6- a glycyl-[tRNA ] 3',5'-ADP sulfite 2 4-methyl-2- kynureninase: L-threonine deacetylase: RUTHE_RS03650 α-Kdo-(2->6)- RUTHE_RS08305 diester dehydrogenase: ATP [tRNA Tyr ] 1,4-lactone precorrin-3A 3,4- adenosylcobinamide HMP-P with a 5' with a 5' methylenetetrahydrofolate in tRNA diaminopimelate oxoglutarate predicted 5-aminolevulinate kynU RUTHE_RS03650 UDP-3-O-(3- lipid IV (E. coli) phosphodiesterase: RUTHE_RS13010 SMP-30/ 4-carboxy-4- dihydroxy-2- kinase/adenosylcobinamide- uroporphyrinogen-III UDP-3-O-(3- A extension and extension and a ABC 5-amino-6-(5- 5-(2-hydroxyethyl) bifunctional hydroxymyristoyl) RUTHE_RS08535 dihydroxyacetone tol-pal system- gluconolactonase/ NAD(+) hydroxy-2- a sugar a sugar butanone-4- phosphate hydroxydecanoyl) a long 3' trailer short 3' extension 3-oxo-(9Z)- NADH-quinone phosphoadenylyl- transporter porphobilinogen phospho-D- 3-hydroxyanthranilate uroporphyrinogen -4-methylthiazole hydroxymethylpyrimidine -α-D-glucosamine tRNA uridine-5- type I secretion succinyl- D-tyrosyl-tRNA(Tyr) D-tyrosyl-tRNA(Tyr) associated LRE family protein: diphosphatase: oxoadipate phosphate guanylyltransferase: cobU 1-deoxy-D- 3-amino-1- -α-D-glucosamine octadecenoyl-CoA sn-glycerol 3-phosphate dihydroxyacetone oxidoreductase: nuoN sulfate reductase: of a sugar synthase: hemB ribitylamino)uracil decarboxylase: kinase/ UDP-3-O-(3- ribonuclease carboxymethylaminomethyl(34) system permease/ diaminopimelate deacylase: deacylase: acyl-CoA RUTHE_RS00100 nudC aldolase/ synthase: xylulose 5- hydroxyacetone hydroxyethylthiazole UDP-3-O-(3- acetyl-CoA C- kinase subunit RUTHE_RS06485 nuoK RUTHE_RS14390 precorrin-3B RUTHE_RS08750 phosphomethylpyrimidine hydroxymyristoyl) P protein acetyl-CoA glycerol-3-phosphate synthesis GTPase MnmE: mnmE ATPase: desuccinylase: RUTHE_RS03090 RUTHE_RS03090 thioesterase: SMP-30/ oxaloacetate porphobilinogen ribB adenosyl-cobinamide phosphate phosphate 1-phosphate kinase: thiM hydroxymyristoyl) acyltransferase: L: dhaL RUTHE_RS06500 nuoI predicted kinase: thiD glucosamine N- ribonuclease D: RUTHE_RS08550 dapE gluconolactonase/ β decarboxylase: 5,6-dimethylbenzimidazole 4-methyl-5-(2- glucosamine N- ribonuclease component: RUTHE_RS08305 dehydrogenase: tRNA uridine-5- nuoH RUTHE_RS06525 ybgC reduced - 1-deoxy-L- 2-amino-3- coproporphyrinogen III acyltransferase: RUTHE_RS01560 LRE family protein: ligK ABC hydroxymethylbilane bifunctional phosphooxyethyl) acyltransferase: D: rnd rnpA RUTHE_RS00840 DHAP carboxymethylaminomethyl(34) nuoE RUTHE_RS06565 [+ 3 isozymes] PAPS nicotinamide D- a sugar a sugar ARP glycero-tetrulose carboxymuconate- nicotinate-nucleotide-- HMP-PP RUTHE_RS04410 ribonuclease acetyl-CoA C- a tRNA Tyr a tRNA Ala RUTHE_RS08855 AMP transporter adenosylcobinamide -dependent thiazole ribonuclease D: synthesis enzyme MnmG: mnmG RUTHE_RS06570 D-tyrosine gly ribonucleotide pyruvate synthase: hemC 4-phosphate 6-semialdehyde dimethylbenzimidazole RUTHE_RS04410 UDP-2-N,3-O-bis[(3R)- D: rnd ribonuclease PH: a tRNA precursor acyltransferase: DHAP L,L- succinate of a sugar kinase/adenosylcobinamide- coproporphyrinogen UDP-2-N-[(3R)-3- RUTHE_RS01560 H + stearate L-gulonate precorrin-4 phosphoribosyltransferase: pyridoxine 3-hydroxytetradecanoyl]- RUTHE_RS10720 with a short RUTHE_RS13365 ADP phosphate diaminopimelate preuroporphyrinogen phosphate oxidase: hemF thiamine phosphate hydroxydodecanoyl]- 34 6,7-dimethyl-8- cobT 5'-phosphate α-D-glucosamine 3' extension a 5-carboxymethylaminomethyluridine predicted 11 guanylyltransferase: cobU a 7,8-dihydrofolate + precorrin-4 (C )- ribityllumazine synthase: 3-O-[(3R)-3- (7Z)-hexadecenoyl-CoA in tRNA NAD menadiol ABC protoporphyrinogen IX pyridoxamine RUTHE_RS04585 hydroxydecanoyl]- a sugar a sugar methyltransferase: synthase: quinolinate α-ribazole 5'-phosphate adenosylcobinamide-GDP transporter 5'-phosphate [+ 2 isozymes] α-D-glucosamine a tRNA ribonuclease D: acyl-CoA cobA RUTHE_RS04745 protoporphyrinogen of a sugar oxidase: pdxH precursor with RUTHE_RS01560 dehydrogenase: Nucleoside and Nucleotide Degradation a 7,8-dihydro- a peptidoglycan a [protein chain an N-terminal- an N-terminal- carboxylating oxidase HemJ: hemJ lipid X ribonuclease PH: a single a D-aspartyl- (2R,3S)-3- precorrin-5 uroporphyrinogen-III molybdenum cofactor biosynthesis a 5' extension RUTHE_RS13510 8-oxoguanine dimer (generic) (R)-β-lysine elongation factor L-methionyl-L- L-methionyl-L- γ-L-glutamyl- gly ser 6,7-dimethyl-8-(1- nicotinate- adenosylcobinamide- PLP thiamine RUTHE_RS10720 ribonuclease stranded DNA [tRNA asp ] isopropylmalate ATP predicted [+ 3 isozymes] in DNA 34 threonyl-[protein] 3-isopropylmalate alanyl-[protein] D-alanine uroporphyrinogen D-ribityl)lumazine nucleotide GDP ribazoletransferase: protoporphyrin IX phosphate D: rnd superpathway of pyrimidine EF-P]-L-lysine biotin threonine/serine ABC ribonuclease (2E,7Z)- purine nucleotides degradation II (aerobic) dehydratase a sugar a sugar decarboxylase: diphosphorylase: RUTHE_RS05895 lipid X (P. putida) deoxyribonucleosides degradation lytic dehydratase: transporter riboflavin synthase: ATP P protein hexadecenoyl-CoA exodeoxyribonuclease small subunit: leuD RUTHE_RS08750 nadC ferrochelatase: adenosylcobalamin lipid A disaccharide bifunctional DNA- transglycosylase EF-P lysine type I methionyl D-tyrosyl-tRNA(Tyr) type I methionyl glutathione RUTHE_RS02360 of a sugar RUTHE_RS04725 GTP component: 2'-deoxycytidine VII large subunit: biotin--[acetyl-CoA- RUTHE_RS10545 salvage from cobalamin (E. coli) enoyl-CoA formamidopyrimidine domain-containing aminoacylase aminopeptidase: deacylase: 3-isopropylmalate aminopeptidase: synthase: precorrin-6A coproporphyrinogen III NaMN adenosylcobalamin 5'-phosphate rnpA AMP RUTHE_RS02175 carboxylase] ligase: L-serine riboflavin cys thiamine tetraacyldisaccharide queuosine hydratase: glycosylase/ protein: GenX: genX map RUTHE_RS03090 dehydratase: map gshB predicted nucleoside exodeoxyribonuclease RUTHE_RS06475 ammonia-lyase: protoheme GTP 3',8- cob(I)alamin diphosphate lipid A 4'-kinase: biosynthesis I (de novo) caiD DNA-(apurinic RUTHE_RS01915 leuD leuC ABC oxygen-dependent nicotinate-nucleotide deaminase: 5'-nucleotidase/ VII small subunit: (2S)-2- RUTHE_RS12015a sugar a sugar bifunctional cyclase disaccharide RUTHE_RS00940 (S)-3-hydroxy-(7Z) or apyrimidinic transporter coproporphyrinogen adenylyltransferase: a carboxy- preQ RUTHE_RS03130 thymidine 2',3'-cyclic RUTHE_RS10675 [+ 5 isozymes] [a protein chain an N-terminal L- isopropylmalate an N-terminal L- pyruvate / MoaA: (P. putida) 0 -hexadecenoyl-CoA site) lyase: mutM met tRNA asp D-aspartate met biotinyl-5'- norophthalmate of a sugar oxidase: hemF RUTHE_RS05160 adenylated lipid IV (E. coli) cytidine deaminase: phosphodiesterase: elongation factor threonyl-[protein] alanyl-[protein] precorrin-6B FAD synthetase: moaA tetraacyldisaccharide A thymidine β adenylate nicotinate adenine adenosylcobalamin [small subunit of an [L-cysteine (8S)-3',8-cyclo-7,8- cob(II)alamin RUTHE_RS02045 RUTHE_RS03020 GlcNAc-1,6- EF-P]-N-( -L- protoporphyrinogen IX RUTHE_RS03210 4'-kinase: phosphorylase: a single-stranded a lipid II 34 dinucleotide molybdopterin desulfurase]-S- NAD de novo biosynthesis IMP a 5'-phospho- a 3'-phospho- 7,8-dihydro- a ribonucleoside anhydro-MurNAc- lysyl)-L-lysine predicted glutathione- dihydroguanosine cob(I)yrinic acid RUTHE_RS00940 an uncharged preQ RUTHE_RS02050 4-oxo-2-pentenal oligodeoxyribonucleotide FMN synthase] sulfanyl-L-cysteine I (from aspartate) 1 2'-deoxyuridine adenosine [DNA] [DNA] 8-oxoguanine 5'-monophosphate pentapeptide ABC protoporphyrinogen NAD+ synthase: folate transformations III (E. coli) peroxide 5'-triphosphate a,c-diamide lipid IV tRNA 3-oxo-(7Z)- a sugar a sugar A GMP transporter oxidase HemJ: hemJ RUTHE_RS06800 redox reactions cyclic pyranopterin adenosyltransferase: (P. putida) tRNA hexadecenoyl-CoA thymine bifunctional monophosphate guanosine(34) adenosine of a sugar precorrin-7 cobO asp acetyl-CoA C- a mature peptidoglycan (meso a 2'- a peptide with an N-terminal- riboflavin kinase/ + a tetrahydrofolate GSSG deaminase: 5'-nucleotidase/ quinoxaline-2- 4-nitrophenyl an L-cysteinyl- protoporphyrin IX NAD synthase cob(II)alamin- L-aspartate oxidase: transglycosylase acyltransferase: uracil deoxyribonucleoside glycerophosphoserine asp O-ureido-L- L-methionyl-L- a protein FAD synthetase: a thiocarboxylated 2',3'-cyclic -diaminopimelate containing) aryl-carrier protein carboxyl adenylate [DNA] an N-terminal butanoate Cys predicted MoaC: moaC [corrinoid Tgt: tgt phosphorylase: RUTHE_RS02060 [tRNA ] dGDP RUTHE_RS03210 [small subunit of cyclic RUTHE_RS11835 RUTHE_RS08305 phosphodiesterase: 5'-triphosphate L-proline homoserine seryl-[protein] ATP-dependent ABC ferrochelatase: adenosyltranferase] Secondary Metabolite Biosynthesis a 7-aminomethyl-7- RUTHE_RS02050 XMP vitamin B12- a sugar a sugar 2-iminosuccinate 34 acetyl-CoA C- transporter RUTHE_RS10545 glutathione- molybdopterin pyranopterin Glycolysis deazaguanosine inosine RUTHE_RS03020 lytic transglycosylase glycerophosphoryl Clp protease dependent FAD acyltransferase: argininosuccinate arylesterase: type I methionyl aminoacyl-tRNA of a sugar precorrin-8x disulfide synthase] phosphate quinolinate in tRNA 5'-nucleotidase/ domain-containing acyl carrier protein: bifunctional diester prolyl proteolytic subunit: ribonucleotide methylerythritol RUTHE_RS13365 guanosine RUTHE_RS02810 DNA primase/ synthase: RUTHE_RS05185 aminopeptidase: hydrolase: RUTHE_RS05205 protoheme reductase: synthase: myo-inositol glycolysis III (from glucose) tRNA preQ1(34) S- purine-nucleoside 2',3'-cyclic protein: phosphodiesterase: aminopeptidase: pip reductase: 6-hydroxymethyl- cob(I)alamin- phosphate pathway I uracil 2-deoxy-α-D- polymerase: RUTHE_RS10685 map RUTHE_RS02580 predicted gorA RUTHE_RS11830 biosynthesis adenosylmethionine (5Z)-tetradecenoyl-CoA phosphorylase: phosphodiesterase: RUTHE_RS01915 acyl carrier protein: RUTHE_RS08535 Clp protease ClpP: RUTHE_RS14625 dihydropterin diphosphate [corrinoid ribose 1-phosphate RUTHE_RS01060 ABC D-glyceraldehyde ribosyltransferase- RUTHE_RS09435 purine-nucleoside RUTHE_RS03020 [+ 6 isozymes] RUTHE_RS16385 RUTHE_RS16520 a sugar a sugar biosynthesis I adenosyltranferase] quinolinate pyruvate D-glucopyranose D-glucopyranose acyl-CoA phosphorylase: [+ 4 isozymes] butanoate 4-nitrophenol GDP transporter molybdopterin 3-phosphate isomerase QueA: queA phosphopentomutase: an N-terminal a peptide hydrogenobyrinate cob(I)yrinic acid 6-phosphate dehydrogenase: RUTHE_RS09435 sn-glycerol a peptide pro canavaninosuccinate a tRNA Cys of a sugar glutathione : an epoxyqueuosine 34 RUTHE_RS02055 hypoxanthine xanthosine a mature peptidoglycan a mature peptidoglycan strand a quinoxaline-2- met L-seryl-[protein] cys coenzyme A biosynthesis GTP a,c-diamide carboxylating 3-phosphate ser hydrogenobyrinate RUTHE_RS04635 in tRNA RUTHE_RS12760 2-deoxy-D-ribose with (L-alanyl-γ-D-glutamyl- (non-reducing terminus) carboxyl-[aryl- I (prokaryotic) GTP cyclohydrolase serine glycine cleavage system adenosyltransferase: nicotinate- guanine AMP [DNA] predicted a,c-diamide synthase: tRNA [+ 3 isozymes] 5-phosphate meso-2,6-diaminopimeloyl- carrier protein] I FolE2: a 7,8-dihydrofolate hydroxymethyltransferase:protein GcvH: agcvH 5-methyltetrahydrofolate cobO nucleotide Ins(3)P D-glucopyranose ABC RUTHE_RS05600 (R)-4'- molybdopterin adenosylcob(III) 1-deoxy-D-xylulose epoxyqueuosine(34) (2E,5Z)- xanthine purine-nucleoside D-alanine) tetrapeptide a sugar a sugar 7,8- RUTHE_RS00210 RUTHE_RS13225[+ 2 isozymes] diphosphorylase: 6-phosphate transporter phosphopantothenate adenine alamin-[corrinoid 5-phosphate reductase QueG: queG tetradecenoyl-CoA deoxyribose- dehydrogenase phosphorylase: hydrogenobyrinate bifunctional dihydroneopterin nadC inositol glucose-6- of a sugar dinucleotide adenosyltranferase] 34 phosphate small subunit: xdhA RUTHE_RS09435 a,c-diamide phosphopantothenoylcysteine 3'-triphosphate 1-deoxy-D-xylulose- monophosphatase: phosphate a queuosine a nascent peptidoglycan a 2'- sn-glycero-3- β-D-fructofuranose a uridine 38- an N-terminal- an N-terminal- molybdopterin cob(I)yrinic acid NaMN 5-phosphate RUTHE_RS00495 enoyl-CoA aldolase: deoxyribonucleoside γ-L-glutamyl-(S)- L-methionyl-L- L-methionyl- cobaltochelatase decarboxylase/ isomerase: in tRNA (meso-DAP containing) dGTP [DNA] phosphoethanolamine 1-phosphate gly 40 in tRNA met dADP predicted tetrahydrofolate biosynthesis molybdotransferase a,c-diamide reductoisomerase: hydratase: deoC 5'-triphosphate 2-aminobutanoate valyl-[protein] glycyl-[protein] subunit CobN: cobN phosphopantothenate-- nicotinate-nucleotide RUTHE_RS12205 xanthine RluA family bifunctional ABC cysteine ligase CoaBC: coaBC MoeA: adenosyltransferase: RUTHE_RS03975 myo-inositol (3E,5Z)-tetradeca- caiD pseudouridine vitamin B12- a sugar a sugar cobaltochelatase (R)-4'- 7,8- (7,8-dihydropterin- a (6S)-5-formyltetrahydrofolate adenylyltransferase: glucose-6- lytic transglycosylase glycerophosphoryl class I fructose- glutamate N- transporter bifunctional RUTHE_RS07330 cobO 3,5-dienoyl-CoA D-glyceraldehyde xanthine synthase: dependent subunit CobS: cobS phosphopantothenoyl- dihydroneopterin 6-yl)methyl MoO - RUTHE_RS05160 phosphate acetaldehyde domain-containing bifunctional diester bisphosphate glutathione type I methionyl type I methionyl acetyltransferase/ of a sugar 4-aminobenzoate 5,10- 2 MEP (S)-3-hydroxy-(5Z) 3-phosphate dehydrogenase ribonucleotide cob(II)yrinate L-cysteine 3'-phosphate diphosphate methylenetetrahydrofolate 5-formyltetrahydrofolate lipoprotein posttranslational deoxyguanosinetriphosphate DNA primase/ synthase: RUTHE_RS08490 aminopeptidase: aminopeptidase: amino-acid methylenetetrahydrofolate molybdopterin adenosylcobalamin nicotinate adenine isomerase: -tetradecenoyl-CoA small subunit: xdhA protein: phosphodiesterase: aldolase: reductase: a,c-diamide bifunctional dehydrogenase/ cyclo-ligase: modification triphosphohydrolase: polymerase: gshB [+ 2 isozymes] map map acetyltransferase predicted cofactor dinucleotide bifunctional 2-C- RUTHE_RS05545 RUTHE_RS01915 RUTHE_RS08535 RUTHE_RS02945 a pseudouridine 38- RUTHE_RS14625 phosphopantothenoylcysteine reductase: metF methenyltetrahydrofolate RUTHE_RS00305 RUTHE_RS07370 RUTHE_RS01060 methyl-D-erythritol a [prolipoprotein]- (3E,5Z)- urate [+ 5 isozymes] 40 in tRNA ArgJ: argJ ABC decarboxylase/ cyclohydrolase FolD: folD NAD+ synthase: NAD+ synthase: F6P N-acetyl-L- ADP a sugar a sugar D-erythro-7,8- 4-phosphate L-cysteine tetradecadienoate [+ 4 isozymes] an N-terminal an N-terminal transporter phosphopantothenate-- a 5,10-methylenetetrahydrofolate a 5,10-methenyltetrahydrofolate RUTHE_RS06800 RUTHE_RS06800 acetyl-CoA sn-glycerol D-glyceraldehyde ophthalmate methionine dihydroneopterin 7,8- cytidylyltransferase/ prolipoprotein 3-oxo-(5Z)- superpathway of purine deoxyribonucleosides degradation a mature peptidoglycan a nascent peptidoglycan ethanolamine DHAP met L-valyl-[protein] met glycyl-[protein] of a sugar cysteine ligase CoaBC: coaBC triphosphate 3-phosphate dihydropteroate bifunctional superpathway of heme b biosynthesis from uroporphyrinogen-III NAD + 2-C-methyl-D- diacylglyceryl tetradecenoyl-CoA with (L-alanyl-γ-D-glutamyl- (meso-DAP containing) 2'-deoxyguanosine heme a biosynthesis dihydroneopterin [DNA] bifunctional methylenetetrahydrofolate erythritol 2,4- transferase: acetyl-CoA C- meso-2,6-diaminopimeloyl- with GlcNAc terminus a sugar RS05485 a sugar 4'-phosphopantetheine aldolase: β-D-fructose 1,6- folylpolyglutamate dehydrogenase/ phosphopantothenate biosynthesis I cyclodiphosphate RUTHE_RS12050 acyltransferase: D-alanine) tetrapeptide protoheme RUTHE_RS01290 uroporphyrinogen-III bisphosphate 2'-deoxyguanosine pantetheine- synthase/ adeninyl adenosylcobamide methenyltetrahydrofolate synthase: a [prolipoprotein]- RUTHE_RS13365 adenosine protoheme IX 6-(hydroxymethyl) 2'-deoxyadenosine phosphate dihydrofolate biosynthesis from cyclohydrolase FolD: folD uroporphyrinogen RUTHE_RS04325 S-1,2-diacyl-sn- acetyl-CoA C- nucleotides a sugar RS09115 a sugar farnesyltransferase: -7,8-dihydropterin 3-methyl-2-oxobutanoate N 6 -dimethylallyladenosine 37 molybdopterin (1S,2R)-1- (S)-4- a [DNA]-3'- a 5'-phospho- D-sedoheptulose a double adenylyltransferase: synthase: adenosylcobinamide-GDP decarboxylase: 2-methyladeninyl 4-(cytidine 5'- fructose- glyceryl-L-cysteine acyltransferase: degradation III a sulfurated tungstate a D-tryptophanyl- 2-oxoglutarate RUTHE_RS01960 an N 10 -formyltetrahydrofolate in tRNA adenine ser C-(indol-3- Trp hydroxymandelate hydroxyl [DNA] 1-phosphate glu ala stranded DNA a protein coaD RUTHE_RS14320 RUTHE_RS08750 adenosylcobamide biosynthesis Ketopantoate diphospho)-2-C- bisphosphate RUTHE_RS08305 purine-nucleoside [sulfur carrier] [tRNA ] ferroheme o signal peptidase II: dinucleotide yl)glycerol mandelate isopropylmalate/ DNA ATP- 3'-dephospho- adenine from adenosylcobinamide-GDP hydroxymethyltransferase: methyl-D-erythritol aldolase class II: adenosine phosphorylase: 7,8-dihydrofolate coproporphyrinogen III RUTHE_RS14885 (3Z)-dodec- AMP 3-phosphate racemase/muconate homocitrate/ topoisomerase dependent Peptide RS09260 Peptide CoA (7,8-dihydropterin- nicotinate-nucleotide-- 5-methylbenzimidazolyl 2-methyladenine RUTHE_RS09100 4-(cytidine 5'- RUTHE_RS00800 deaminase: RUTHE_RS09435 ATP-dependent class I fructose- heme A synthase: monoglutamate 3-enoyl-CoA purine-nucleoside succinate molybdopterin D-tyrosyl-tRNA(Tyr) lactonizing enzyme citramalate glutamate-- (ATP- protease 6-yl)methyl dimethylbenzimidazole adenosylcobamide biosynthesis nicotinate-nucleotide-- [+ 2 isozymes] diphospho)- class I fructose- AMP nucleosidase: purine ribonucleosides degradation RUTHE_RS02060 DNA ligase: bisphosphate RUTHE_RS04575 dephospho- an (S-diacyl- a lipoprotein phosphorylase: dehydrogenase, molybdotransferase tryptophan deacylase: family protein: synthase: cysteine ligase: hydrolyzing) subunit diphosphate phosphoribosyltransferase: from adenosylcobinamide-GDP oxygen-dependent oxygen-independent dimethylbenzimidazole 2-C-methyl-D- bisphosphate RUTHE_RS15115 RUTHE_RS06935 aldolase: CoA kinase: sn-glyceryl) signal peptide purine-nucleoside RUTHE_RS09435 hydrophobic MoeA: synthase RUTHE_RS03090 RUTHE_RS00530 RUTHE_RS06910 RUTHE_RS13430 subunit B: gyrB HslV: hslV ferroheme i cobT coproporphyrinogen coproporphyrinogen phosphoribosyltransferase: 2-dehydropantoate : aldolase: adenine RUTHE_RS02945 Peptide RS05265 Peptide coaE adenine ribotide 5-methylbenzimidazole -L-cysteinyl- phosphorylase: membrane anchor RUTHE_RS07330 subunit [+ 3 isozymes] (2R)-homocitrate [+ 2 isozymes] nicotinate-nucleotide-- oxidase: hemF III oxidase: hemN cobT RUTHE_RS10985 RUTHE_RS02945 [apolipoprotein] (2E)-dodec- adenosine 2'-deoxyinosine beta: trpB (R)-4- a negatively a peptide a 7,8-dihydrofolate phosphate RUTHE_RS09435 protein: sdhD [DNA] γ heme A synthase: coenzyme A dimethylbenzimidazole 2-phospho-4-(cytidine 2-enoyl-CoA WO - hydroxymandelate -L-glutamyl- supercoiled DNA NAD salvage pathway I (PNC VI cycle) 2-methyladenine 2 D-tryptophan a tRNA Trp DHAP D-erythrose RUTHE_RS04575 phosphoribosyltransferase: 5'-diphospho)-2-C- crotonobetainyl- adenosine molybdopterin D-glyceraldehyde D-alanine adenosylcobinamide- protoporphyrinogen IX protoporphyrinogen IX ribotide phosphate triose-phosphate 2-deoxy-α-D-ribose 1-phosphate 2-methylsulfanyl-N 6 - AMP Peptide RS13160 Peptide cobT β-alanine methyl-D-erythritol a peptide CoA deaminase: cofactor 3-phosphate trp GDP (R)-pantoate isomerase: an N-acyl-(S- 5'-deoxyadenosine dimethylallyladenosine 37 an unsulfurated hydroxyferroheme i NAD + 5-methylbenzimidazole adenosylcobinamide- bifunctional 2-C- hydratase: caiD met ribazoletransferase: RUTHE_RS13530 diacyl-sn-glyceryl) RUTHE_RS02060 phosphopentomutase: in tRNA [sulfur carrier] NAD(+) a tetrahydrofolate ribotide phosphate protoporphyrinogen GDP methyl-D-erythritol (S)-3- RUTHE_RS02055 α α RUTHE_RS05895 triose-phosphate -L-cysteinyl- diphosphatase: nudC Co -[ -(adenin- adenosylcobinamide- oxidase HemJ: hemJ ribazoletransferase: pantoate--beta-alanine 4-phosphate hydroxydodecanoyl-CoA xanthosine adenosine inosine guanosine nitrate RS00635 nitrate NAD+ synthase: 9-yl)]-Coβ- isomerase: [lipoprotein] GDP RUTHE_RS05895 ligase: RUTHE_RS00390 cytidylyltransferase/ 2-deoxy-D-ribose 5-phosphate 34 an sn-glycero-3- RUTHE_RS06800 benzimidazolyl adenosylcobamide Coα-[α-(2- RUTHE_RS00815 a 5,10- a 2-thiouridine a cytosine 32 an [L-cysteine an N-modified NAD+ synthase: adenosylcobamide ribazoletransferase: 2-C-methyl-D- D-glyceraldehyde phospho-N-(acyl) canavaninosuccinate hydantoin 3'-cmp SAICAR acetamide 5-MTR-1-P ferroheme a biosynthesis from protoporphyrin IX methyladenin-9-yl)]-Co DHAP methylenetetrahydrofolate in tRNA in tRNA desulfurase]-S- aminoacyl-[tRNA] L-homoserine RUTHE_RS06800 5'-phosphate RUTHE_RS05895 erythritol 2,4- 3-phosphate ethanolamine 5'/3'-nucleotidase adenosylcobinamide-GDP β-adenosylcobamide (R)-pantothenate purine-nucleoside purine-nucleoside purine-nucleoside purine-nucleoside deoxyribose- sulfanyl-L-cysteine hydantoinase acetamidase/ S-methyl-5- nitrate RS12400 nitrate Coα-[α-(5- cyclodiphosphate type I homoserine O- SurE: surE nicotinate adenine dinucleotide NMN NAD salvage ferrochelatase: 6 37 3-oxododecanoyl-CoA phosphorylase: phosphorylase: phosphorylase: phosphorylase: phosphate B/oxoprolinase formamidase thioribose-1- methylbenzimidazolyl)]- benzimidazole 5'-phosphate synthase: N -L-threonylcarbamoyladenosine tRNA uridine-5- succinyltransferase: adenylosuccinate pathway III (to nicotinate-nucleotide-- RUTHE_RS10545 type III pantothenate glyceraldehyde- RUTHE_RS09435 RUTHE_RS09435 RUTHE_RS09435 RUTHE_RS09435 aldolase: deoC tRNA 2- glycerophosphoryl aminoacyl-tRNA argininosuccinate family protein: bifunctional 2',3'- family protein: phosphate α α Coβ-adenosylcobamide RUTHE_RS04325 -modified tRNA biosynthesis acetyl-CoA C- carboxymethylaminomethyl(34) RUTHE_RS04525 lyase: nicotinate-nucleotide nicotinamide riboside) Co -[ -(adenin- dimethylbenzimidazole kinase: RUTHE_RS06470 3-phosphate thiocytidine(32) diester hydrolase: lyase: argH RUTHE_RS09040 cyclic-nucleotide 2'- RUTHE_RS00280 isomerase: β synthesis GTPase MnmE: mnmE RUTHE_RS02720 2+ 2+ thiamine diphosphate 7-yl)]-Co - 5'-phosphate protoheme 2-C-methyl-D-erythritol- dehydrogenase: acyltransferase: α-D-ribose- synthetase phosphodiesterase: RUTHE_RS02580 [+ 3 isozymes] O-succinyl-L- phosphodiesterase/ amidase: mtnA Cd RS00060 Cd adenylyltransferase: NADP + phosphoribosyltransferase: Coα-[α-(2- 5-(methylsulfanyl) biosynthesis I (E. coli) adenosylcobamide (R)-4'-phosphopantothenate 2,4-cyclodiphosphate gap ATP RUTHE_RS08305 1-phosphate acetaldehyde D-glyceraldehyde 3-phosphate tRNA uridine-5- TtcA: ttcA RUTHE_RS08535 homoserine 3'-nucleotidase: RUTHE_RS08370 RUTHE_RS05160 cobT methyladenin-7-yl)]-Co thr N-carbamoylglycine -ribulose 1- 2-[(2R,5Z)- benzimidazole acetyl-CoA C- pseudouridine carboxymethylaminomethyl(34) L-canavanine fumarate RUTHE_RS11010 β-adenosylcobamide flavodoxin- thymine degradation phosphopentomutase: AICAR fumarate acetate phosphate Coα-[α-(5- ribotide phosphate 13-DPG acyltransferase: synthesis enzyme MnmG: mnmG 32 an [L-cysteine an N-modified an uncharged 2-carboxy-4- NaMN nicotinamide degradation a 2-thiocytosine cytidine Cd 2+ RS13915 Cd 2+ NAD + methylbenzimidazolyl)]- dependent RUTHE_RS13365 RUTHE_RS02055 desulfurase]- sn-glycerol an N- tRNA methylthiazol-5(2H adenosylcobinamide- folate polyglutamylation (E)-4-hydroxy- threonylcarbamoyl- thymine in tRNA Coβ-adenosylcobamide D-ribose 5- pseudouridine L-cysteine 3-phosphate acylethanolamine HMP-PP )-ylidene]ethyl bifunctional NAD(+) di-trans,poly-cis GDP thiamine diphosphate 3-methylbut- AMP synthase: dihydrothymine acetyl-CoA UTP and CTP dephosphorylation I a 5-aminomethyl-2- menaquinol-7 biosynthesis decanoyl-CoA phosphate pseudouridine a 7,8-dihydrofolate 34 phosphate nicotinamidase/ diphosphatase: -undecaprenyl ribazoletransferase: biosynthesis II (Bacillus) 2-enyl- RUTHE_RS12755 dehydrogenase: thiouridine in tRNA nicotinate a tetrahydrofolate kinase: Cd 2+ RS07665 Cd 2+ phosphate biosynthesis RUTHE_RS05895 3-phospho- acyl-CoA preA UTP phosphoribosyltransferase: pyrazinamidase: pncA nudC α α 2-(2-carboxy-4- all-trans- diphosphate RUTHE_RS04200 thiamine phosphate (2E,6E)-farnesyl Co -[ -(benzimidazolyl) (R)-glycerate (L-threonylcarbamoyl) dehydrogenase: 5,6-dihydrothymine pncB IPP β methylthiazol-5- heptaprenyl 1,4-dihydroxy- synthase: ispG pseudouridine 1498 (3R,5S)-3- synthase: NMN diphosphate glutathione ]-Co -adenosylcobamide HMP-PP adenylate a purine base + 4-nitrophenyl a ribonucleoside a uracil 3'-UMP a [protein]-L- nicotinate formate-- serine bifunctional yl)ethyl phosphate diphosphate 2-naphthoate (E)-4-hydroxy-3- RUTHE_RS13510 hydantoinase 5'-phosphate nucleoside [DNA] NADPH NAD adenosylcobinamide pyrazinamide hydroxy-1- RUTHE_RS04585 biosynthesis 5'-phosphate triphosphate lesion in DNA palmitate diphosphate in 16S rRNA methionine a metal a metal tetrahydrofolate hydroxymethyltransferase: folylpolyglutamate methylbut-2-en- IPP tRNA (adenosine(37)-N6)- [+ 3 isozymes] B/oxoprolinase bifunctional vitamin B12- 16S rRNA 5'/3'-nucleotidase amidase: pyrroline-5- peptide- RS00250 [+ 2 isozymes] 5'-nucleotidase/ di-trans,poly-cis- pseudouridine- hydrolase: cation cation ligase: RUTHE_RS13225 synthase/ thiamine phosphate 1-yl diphosphate threonylcarbamoyltransferase family protein: pyrimidine deoxyribonucleotides CTP adenosylcobinamide dependent (uracil(1498)-N(3))- SurE: surE RUTHE_RS08370 carboxylatepyrroline-5- methionine thioredoxin 2',3'-cyclic decaprenylcistransferase: cys glu 2-phospho- (2E)-dec-2-enoyl-CoA 5'-phosphate RUTHE_RS05820 bifunctional DNA- exodeoxyribonuclease NAD(P)(+) tetrahydrofolate salvage from RUTHE_RS07090 dihydrofolate synthase: complex dimerization RUTHE_RS09040 dephosphorylation kinase/ arylesterase: ribonucleotide methyltransferase: bifunctional 2',3'- bifunctional carboxylate (S)-S-oxide pathway phosphodiesterase: uppS D-glycerate glycosidase: nucleoside formamidopyrimidine III: RUTHE_RS08405 transhydrogenase thiamine 5,10-methenyltetrahydrofolate Coα-[α-(benzimidazolyl) a 5,10- synthase: subunit type 1 TsaB: tsaB 2 nucleoside triphosphate adenosylcobinamide- RUTHE_RS03020 RUTHE_RS04585 trans-∆ - [+ 3 isozymes] triphosphate RUTHE_RS05185 reductase: 3 RUTHE_RS12735 cyclic-nucleotide 2'- nicotinamidase/ reductase: reductase 10 demethylmenaquinol-7 phosphopyruvate RUTHE_RS04195 an N - a metal a metal phosphate an oxidized β ]-Coβ-adenosylcobamide an N - methylenetetrahydrofolate RUTHE_RS14320 tRNA (adenosine(37)-N6)- pyrophosphohydrolase: UDP glycosylase/ exodeoxyribonuclease (Re/Si-specific) phosphate MsrA: msrA RS12595 a 5,10- 1-( -D di-trans,octa-cis glutamate-- [+ 2 isozymes] hydratase: decenoyl-CoA 3-(carbamoylamino)- hydrolase: a 2'- RUTHE_RS14625 methyluracil 1498 phosphodiesterase/ pyrazinamidase: RUTHE_RS12065 a protein-L- cation cation formyltetrahydrofolate threonylcarbamoyltransferase mazG uracil DNA-(apurinic III: xth subunit beta: guanylyltransferase: methenyltetrahydrofolate thioredoxin ribofuranosyl) -undecaprenyl cysteine ligase: bifunctional bifunctional RUTHE_RS05660 hydratase: 2-methylpropanoate RUTHE_RS05820 deoxyribonucleoside in 16S rRNA 3'-nucleotidase: pncA Hyp methionine- bifunctional DMAPP complex: tsaD tsaE dCTP dCMP or apyrimidinic RUTHE_RS05300 cobU pyrazine-2- nicotinamide diphosphate RUTHE_RS13430 bifunctional folylpolyglutamate a tetrahydrofolate thiamine demethylmenaquinone caiD 4-nitrophenol palmitate 5'-diphosphate RUTHE_RS11010 (S)-S-oxide methylenetetrahydrofolate phosphoenol an N 6 -L- CDP site) lyase: mutM a 2'- carboxylate folylpolyglutamate synthase/ phosphate methyltransferase/2- UMP adenosyl-cobinamide uridine a metal a metal undecaprenyl- pyruvate 37 (S)-3- S-methyl-5'- [DNA] thiamine dehydrogenase/ thioredoxin- synthase/ dihydrofolate threonylcarbamoyladenine dUTP diphosphatase: deoxyribonucleoside phosphate RS12605 diphosphate γ-L-glutamyl- glutathione- methoxy-6-polyprenyl- hydroxydecanoyl-CoA thioadenosine + cation cation diphosphate methenyltetrahydrofolate disulfide synthase: pyruvate in tRNA RUTHE_RS09560 5'-nucleotidase/ 5'-monophosphate NADH NADP phosphatase: L-cysteine glutaredoxin dihydrofolate 1,4-benzoquinol (R)-3-amino-2- degradation I a 5'-phospho- a 3'-phospho- a modified cyclohydrolase FolD: folD reductase: RUTHE_RS14320 kinase: pyk 2',3'-cyclic 4-oxo-2-pentenal an N 10 - lipoate biosynthesis RUTHE_RS09745 redox reactions synthase: methylase UbiE: ubiE methylpropanoate nucleoside triphosphate S-methyl-5'- CMP [DNA] [DNA] nucleobase trxB glutathione phosphodiesterase: formyltetrahydrofolate and incorporation I di-trans,octa-cis RUTHE_RS14320 a 5,10- menaquinol-6 biosynthesis thiamine pyrophosphohydrolase: thioadenosine a metal a metal synthase: glutathione menaquinol-7 pyruvate 5'-nucleotidase/ RUTHE_RS03020 RS12725 phosphoribosylglycinamide -undecaprenyl an N 10 - methylenetetrahydrofolate diphosphate mazG cation cation gshB N-end rule pathway I (prokaryotic) 3-oxodecanoyl-CoA a nascent peptidoglycan a 3-(acyloxy) 2030 2251 a [lipoyl-carrier phosphate dUTP dUMP 2',3'-cyclic uridine a peptidoglycan adenine guanosine L,L- S-adenosyl- formyltransferase: an octanoyl-[acp] formyltetrahydrofolate gly with (L-alanyl-γ-D-glutamyl- glycerophosphoglycerol acyl group of acetoacetyl-CoA a phenyl acetate protein]-N 6 -[(R) 3',5'-ADP a reduced glutathione demethylmenaquinol-6 acetyl-CoA C- MTR phosphodiesterase: in 23S rRNA in 23S rRNA diaminopimelate L-methionine RUTHE_RS07525 lipoyl(octanoyl) leucyl/phenylalanyl- meso-2,6-diaminopimeloyl- bacterial toxin 23S rRNA 23S rRNA 3-hydroxybutyryl- -dihydrolipoyl]- 3'(2'),5'- thioredoxin a reduced bifunctional acyltransferase: RUTHE_RS03020 a metal a metal biosynthesis transferase tRNA--protein S-methyl-5'- 5-hydroxy-CTP 5-hydroxy-CMP S-methyl-5- D-alanine) tetrapeptide (adenine(2030)-N(6) (guanosine(2251) CoA L-lysine bisphosphate RS00030 a tetrahydrofolate glutaredoxin demethylmenaquinone RUTHE_RS08305 lysozyme: glycerophosphoryl diaminopimelate dihydrolipoyl cation cation a [lipoyl-carrier protein]LipB: lipB menaquinol-9 biosynthesis menaquinol-8 biosynthesis transferase: thioadenosine thioribose kinase: cytidine )-methyltransferase -2'-O)- dehydrogenase: arylesterase: nucleotidase methyltransferase/2- a [protein] L,D-transpeptidase: RUTHE_RS11655 diester acyloxyacyl epimerase: dapF dehydrogenase: met 6 glutaredoxin an N-terminal RUTHE_RS05785 acetyl-CoA C- degradation II RlmJ: methyltransferase RUTHE_RS11045 RUTHE_RS05185 N -octanoyl-L-lysine methoxy-6-polyprenyl- N-terminal L- RUTHE_RS12690 RUTHE_RS15740 lysozyme: hydrolase: (S)-3- lpdA CysQ: cysQ methionine 3: grxC arginyl-[protein] acyltransferase: S-methyl-5'- phosphodiesterase: RUTHE_RS06665 RlmB: rlmB meso- a [lipoyl-carrier demethylmenaquinol-9 1,4-benzoquinol leucyl-L-arginine RUTHE_RS04540 6 a metal a metal adenosyltransferase: lipoyl demethylmenaquinol-8 [+ 5 isozymes] RUTHE_RS13850 RUTHE_RS08535 an N - 2-O- hydroxybutanoyl- 6 a protein with RUTHE_RS13365 thioadenosineS-methyl-5'- 5-MTR-1-P diaminopimelate protein]-N - AMP RS06720 RUTHE_RS02500 synthase: lipA bifunctional methylase UbiE: ubiE bifunctional methyladenine 2030 methylguanosine 2251 CoA cation cation reduced L- thioadenosine lipoyl-L-lysine SAM a [lipoyl-carrier demethylmenaquinone menaquinol-6 demethylmenaquinone leucyl/phenylalanyl- octanoyl-CoA a nascent peptidoglycan a 3-hydroxyacyl in 23S rRNA in 23S rRNA acetate a phenol cysteine residues phosphorylase: N-acetyl-D- a N-acetylmuramoyl- a fatty acid protein]-N 6 -[(R)- methyltransferase/2- methyltransferase/2- tRNA--protein with (L-alanyl-γ-D-glutamyl- D-ala glycerol sn-glycerol group of acyl-CoA mtnP glucosamine pentapeptide- dihydrolipoyl]-L-lysine methoxy-6-polyprenyl- methoxy-6-polyprenyl- transferase: meso-2,6-diaminopimeloyl- diphosphoundecaprenol 3-phosphate bacterial toxin D-ribose RS02455 D-ribose 1,4-benzoquinol a [protein] dehydrogenase: 5-MTR-1-P 1,4-benzoquinol an N-terminal RUTHE_RS05785 glycine) tetrapeptide Mg 2+ RS00300 Mg 2+ methylase UbiE: ubiE N-terminal L- RUTHE_RS13510 methylase UbiE: ubiE L-lysyl-[protein] menaquinol-9 menaquinol-8 leucyl-L-lysine [+ 3 isozymes] 1402 an [amino group carrier 6-O-trans- Fatty Acid and Lipid Biosynthesis a [2-oxoglutarate- a cytidine long chain D-ribose RS00865 D-ribose (2E)-oct-2-enoyl-CoA a sulfurated DL-allothreonine D-ala 2-oxoglutarate 2-oxoglutarate protein]-C-terminal-γ- phenyl acetate roseoflavin methoxy-mycolyl- SAM dehydrogenase in 16S rRNA polyphosphate a protein Aromatic Compound Degradation [sulfur carrier] 6 16S rRNA (L-glutamyl)-L-glutamate bifunctional trehalose 6- Fe 3+ RS07775 Fe 3+ palmitate biosynthesis II E2 protein] N - RNA degradosome crotonobetainyl- riboflavin kinase/ (bacteria and plant cytoplasm) oleate biosynthesis palmitoleate gondoate biosynthesis C1 Compound Utilization octanoyl-L-lysine (cytidine(1402)-2'-O) acetylglutamate polyphosphate endopeptidase La: phosphate biotin-carboxyl carrier Respiration CoA 2-oxoglutarate FAD synthetase: trehalose- predicted IV (anaerobic) biosynthesis I (from (anaerobic) and Assimilation catechol degradation to 2- serine D-amino acid -methyltransferase: kinase: argB kinase: arylesterase: RUTHE_RS14430 protein assembly Nucleoside and Nucleotide Biosynthesis hydratase: caiD protocatechuate degradation 4-sulfocatechol catechol degradation to lipoyl dehydrogenase RUTHE_RS03210 phosphatase: ABC (5Z)-dodec-5-enoate) hydroxypentadienoate II hydroxymethyltransferase: aminotransferase: a 2'-O- rsmI an [amino group carrier RUTHE_RS06370 RUTHE_RS05185 sulfate sulfate an acetoacetyl-[acp] 2-oxoglutarate decarboxylation to succinyl-CoA (S)-3- II (ortho-cleavage pathway) degradation 2-hydroxypentadienoate I synthase: E1 component: roseoflavin trehalose-otsB transporter a (3R)-3- a (5Z)-dodec- formate assimilation into 5,10- RUTHE_RS13225 RUTHE_RS10695 1402 long chain hemin RS09070 hemin a malonyl-[acp] an oleoyl-[acp] a [biotin carboxyl- superpathway of pyrimidine RUTHE_RS09370 methylcytidine protein]-C-terminal- 5'-phosphate a peptide trans-methoxy- of sulfate hydroxydodecanoyl-[acp] 5-enoyl-[acp] 5-aminoimidazole adenine and adenosine salvage III hydroxyoctanoyl-CoA methylenetetrahydrofolate catechol lipA γ polyphosphate 3-oxoacyl-[acyl- 3-hydroxyacyl- beta-ketoacyl- carrier protein]-L-lysine ribonucleotides de novo biosynthesis superpathway of guanosine adenine and a [2-oxoglutarate protocatechuate 4-sulfocatechol catechol in 16S rRNA -(5-phospho-L- mono-mycolate ribonucleotide biosynthesis I catechol 2,3- acetate phenol carrier-protein] ACP dehydratase ACP synthase biotin--[acetyl-CoA- adenosine nucleotides deoxyribonucleotides adenosine salvage I dehydrogenase protocatechuate protocatechuate a [2-oxoglutarate glutamyl)-L-glutamate sulfate RS03470 sulfate beta-ketoacyl- 6 formate dioxygenase: an unsulfurated acetaldehyde pyruvate reductase: fabG FabZ: fabZ II: fabF carboxylase] ligase: de novo biosynthesis I de novo biosynthesis I E2 protein] N 3,4-dioxygenase: 3,4-dioxygenase: catechol 2,3- 5'-deoxyadenosine met dehydrogenase gly D-glt CO NADH succinyl-CoA gln 2 2+ 2+ a (7Z)-3-oxotetradec- ACP synthase PRPP 2-oxoglutarate formate-- RUTHE_RS02265 dioxygenase: 6 [sulfur carrier] Ca RS02165 Ca bifunctional 3- RUTHE_RS06475 hydrogencarbonate adenine -lipoyl-L-lysine pcaH pcaG pcaH pcaG E2 protein] N a (3R)-3- 7-enoyl-[acp] II: fabF adenosine dehydrogenase 3-oxooctanoyl-CoA tetrahydrofolate HMS RUTHE_RS02265 hydroxydecanoyl- a [biotin carboxyl- IMP purine-nucleoside GDP 2-oxoglutarate 3-carboxy-cis,cis-muconate 3-sulfomuconate -lipoyl-L-lysine hydroxybutanoyl-[acp] carrier protein]-N asp phosphorylase: purine-nucleoside dehydrogenase E1 component: ligase: sulfate RS09175 sulfate ACP dehydratase/ 3-oxoacyl- glutamine- 5-phospho-β- vitamin B12- acetyl-CoA C- HMS 3-hydroxyacyl- 6 phosphorylase: RUTHE_RS09370 10 RUTHE_RS07090 trans-2- [acyl-carrier- an (11Z)-3-oxo- -biotinyl-L-lysine RUTHE_RS09435 dependent E1 component: acyltransferase: an N - a 5-methylaminomethyl- a 5,6- 6-O-cis-methoxy- hydrolyzing D-ribosylamine RUTHE_RS09435 a methylated a cytidine 1402 an [RNA]-3'- an insertion cobalt- fluoride RS07245 fluoride ACP dehydratase adenosine RUTHE_RS09370 geranyl 34 α 20 decenoyl-ACP protein] icos-11-enoyl-[acp] carbamoyl- adenylosuccinate ribonucleotide RUTHE_RS08305 formyltetrahydrofolate (2Z,4E)-2- selenophosphate 2-thiouridine 2-oxoglutarate nucleobase succinate -D- ribonucleoside- dihydrouracil sequence mycolyl-trehalose a protein FabZ: fabZ adenine diphosphate ATP in 16S rRNA precorrin-5B isomerase: fabA reductase: 3-oxoacyl-[acyl- phosphate synthase: reductase: dihydrolipoyl acetyl-CoA C- bifunctional hydroxyhexa- (2-carboxy-2,5-dihydro- in tRNA within DNA glucopyranose 16S rRNA 2',3'- in tRNA element IS30 cobalt-precorrin- 6-phosphate sulfite RS10955 sulfite bifunctional 3- fabG adenosine RUTHE_RS14625 dehydrogenase: 4-sulfomuconolactone tRNA : trehalose- a (2E)-dodec-2-enoyl-[acp] carrier-protein] a [biotin carboxyl- synthase RUTHE_RS14765 adenine a [2-oxoglutarate a [2-oxoglutarate acyltransferase: methylenetetrahydrofolate 2,4-dienedioate 5-oxofuran-2-yl)-acetate 1-phosphate (cytosine(1402)-N(4) cyclophosphate 5B (C(1))- hydroxydecanoyl- a (3R,7Z)-3- deaminase: dGDP lpdA (2Z)-2- ADP-forming RNA 2',3'-cyclic dihydrouridine(20/ RUTHE_RS00155 phosphatase: metalloprotease reductase: fabG carrier-]- small phosphoribosyltransferase: dehydrogenase dehydrogenase RUTHE_RS13365 dehydrogenase/ alpha-ketoglutarate- )-methyltransferase methyltransferase: heme b RS15845 heme b hydroxytetradec- 6 GAR RUTHE_RS02060 4-carboxymuconolactone hydroxypenta- formate tRNA 2- succinate--CoA phosphodiesterase: 20a) synthase transposase: TldD: tldD ACP dehydratase/ bifunctional 3- N -biotinyl-L-lysine 6 6 methenyltetrahydrofolate dependent glucose-1-phosphate RsmH: rsmH RUTHE_RS16410 otsB 7-enoyl-[acp] a (3R,11Z)-3-hydroxy- subunit: carA adenylo-succinate RUTHE_RS02015 E2 protein] N E2 protein] N -S- decarboxylase: pcaC 2,4-dienoate selenouridine(34) ligase: sucD sucC an N 4 - thpR DusA: dusA RUTHE_RS13935 trehalose- sulfite RS08295 sulfite trans-2- hydroxydecanoyl- acetyl-CoA phosphoribosylglycinamide nucleoside- hexanoyl-CoA cyclohydrolase FolD: folD dioxygenase AlkB: adenylyltransferase: an [RNA]-3'- an insertion cobalt- icos-11-enoyl-[acp] -dihydrolipoyl- succinyldihydrolipoyl- synthase methylcytidine 1402 20 cis-methoxy- a peptide decenoyl-ACP ACP dehydratase/ bifunctional 3- acetyl-CoA carboxylase inosine diphosphate kinase: (3E)-2-oxohex- (4,5-dihydro-5- ribunucleoside- a uracil in tRNA sequence IS30 precorrin-6A adenylosuccinate formyltransferase: AMP L-lysine L-lysine a 5,10- 2-maleylacetate MnmH: mnmH RUTHE_RS09940 glgC in 16S rRNA mono-mycolate isomerase: fabA trans-2- hydroxydecanoyl- bifunctional 3- carboxylase: biotin carbamoyl asp RUTHE_RS14460 acyl-CoA 3-enedioate oxofuran-2-yl)-acetate 2'-phosphate with integrated 2+ 2+ lyase: RUTHE_RS07525 methenyltetrahydrofolate Zn RS11985 Zn decenoyl-ACP ACP dehydratase/ hydroxydecanoyl- RUTHE_RS02730 carboxylase phosphate purine-nucleoside dehydrogenase: phosphate succinyl-CoA transposon RUTHE_RS02720 bifunctional 3-oxoadipate enol- a 5-methylaminomethyl- (2E)-3,7- a nucleobase ADP predicted a (2E)-but-2-enoyl-[acp] isomerase: fabA trans-2- ACP dehydratase/ subunit: accC FGAR phosphorylase: dGTP RUTHE_RS13510 formaldehyde succinate ADP-α-D-glucose methylenetetrahydrofolate lactonase: pcaD 2-selenouridine 34 dimethylocta- within DNA ABC decenoyl-ACP trans-2- a [carboxyl-carrier aspartate RUTHE_RS09435 [+ 3 isozymes] urea urea isomerase: fabA AMP phosphoribosylformylglycinamidine 2-oxoglutarate Pentose Phosphate Pathways dehydrogenase/ (2Z)-2- in tRNA 2,6-diene-1-thiol transporter a (3Z)-dodec-3-enoyl-[acp] decenoyl-ACP protein dimer]-N 6 - carbamoyltransferase dehydrogenase hydroxypenta- 3-oxoadipate 3-oxoadipate of urea catalytic subunit: synthase subunit PurL: purL hypoxanthine trans-hex-2-enoyl-CoA methenyltetrahydrofolate 3-hydroxyacyl- isomerase: fabA carboxybiotinyl-L-lysine E1 component: cyclohydrolase FolD: folD 2,4-dienoate beta-ketoacyl- RUTHE_RS06995 phosphoribosylformylglycinamidine pentose phosphate pathway 4 6-O-trans-keto- acetate acetate ACP 3-hydroxyacyl- : RUTHE_RS09370 crotonobetainyl- a [protein]- an O - ACP synthase synthase subunit PurS: purS xanthine (non-oxidative branch) a 5,10- cob(II)inamide a D-aminoacyl- (S)-2- meso- (S)-5-hydroxyisourate histidinol acetaldehyde a nucleoside mycolyl-trehalose a butanoyl-[acp] dehydratase ACP dehydratase RUTHE_RS11220 CoA L-cysteine methylthymine glu acyl-carrier protein RS12655 II: fabF phosphoribosyltransferase: guanine and guanosine salvage II 2-oxoglutarate methylenetetrahydrofolate ATP [tRNA] aminobutanoate diaminopimelate histidinol triphosphate 6-phosphate a metal a metal FabZ: fabZ FabZ: fabZ N-carbamoyl- FGAM D-ribulose hydratase: caiD in DNA aldehyde nucleoside RUTHE_RS14970 dehydrogenase ACP S- hydroxyisourate dehydrogenase: hisD dehydrogenase trehalose- cation cation beta-ketoacyl- a (5Z)-3-oxo- a (2E,7Z)-tetradeca- phosphatidylserine and L-aspartate 5-phosphate (S)-3- diaminopimelate triphosphate a (2E,11Z)-icosa- ADP hypoxanthine complex methylated-DNA-- malonyltransferase: hydrolase: uraH (NADP(+)): phosphatase: ACP synthase tetradec-5-enoyl-[acp] 2,7-dienoyl-[acp] phosphatidylethanolamine phosphoribosylformylglycinamidine hydroxyhexanoyl-CoA cob(I)yrinic acid D-tyrosyl-tRNA(Tyr) glutamate-- decarboxylase: lysA histidinol hydrolase: 2,11-dienoyl-[acp] dihydroorotase: phosphoribosyltransferase: hpt guanosine dihydrolipoyllysine- [protein]-cysteine S- fabD (S)-2-oxo-4- RUTHE_RS14565 otsB II: fabF 3-oxoacyl-[acyl- biosynthesis I cyclo-ligase: RUTHE_RS07530 ribulose- ribose-5- 3-hydroxyhexanoyl- Amine and Polyamine Degradation a,c-diamide deacylase: cysteine ligase: dehydrogenase: hisD RUTHE_RS05820 trehalose- pyrC vitamin B12- residue methyltransferase: hydroxy-4-carboxy- a nucleoside carrier-protein] succinyltransferase: phosphate 3- phosphate CoA adenosyltransferase: RUTHE_RS03090 RUTHE_RS13430 a malonyl-[acp] lys his acetate trans-keto- a 3-oxohexanoyl-[acp] a CDP-diacylglycerol dependent AIR IMP RUTHE_RS08635 5-ureidoimidazoline diphosphate mono-mycolate reductase: fabG (S)-dihydroorotate odhB epimerase: isomerase dehydrogenase: glycine betaine degradation I cobO CDP-diacylglycerol--serine ribonucleotide N-acetylglucosamine 4-aminobutanoate allantoin degradation a (7Z)-tetradec- rpe RpiA: rpiA RUTHE_RS11045 γ-L-glutamyl-(S)- 3-oxoacyl-[acyl- a (3R,5Z)-3-hydroxy- O-phosphatidyltransferase: reductase: guanine degradation II degradation I to glyoxylate I a [protein]-S- an uncharged 7-enoyl-[acp] a gondoyl-[acp] quinone-dependent adenosylcobinamide a thymine in DNA a D-amino acid 2-aminobutanoate carrier-protein] tetradec-5-enoyl-[acp] RUTHE_RS09300 RUTHE_RS14625 superpathway of pyrimidine D-xylulose D-ribose 5- 3-oxohexanoyl-CoA glycine betaine N-acetyl-D- methyl-L-cysteine tRNA dihydroorotate triphosphate reductase: fabG bifunctional 3- beta-ketoacyl- phosphatidylcholine/ nucleobases salvage xanthine 5-phosphate phosphate betaine--homocysteine glucosamine 4-aminobutanoate (S)-(+)-allantoin dehydrogenase: superpathway of pyrimidine deoxyribonucleoside salvage phosphoribosyltransferase: acetyl-CoA C- putative N- a (3R)-3- hydroxydecanoyl- ACP synthase phosphatidylserine dADP uracil S-methyltransferase: bmt 4-aminobutyrate- allantoinase II: fabF synthase: RUTHE_RS03010 RUTHE_RS14970 acetyltransferase: acetylglucosamine -2-oxoglutarate hydroxyhexanoyl-[acp] ACP dehydratase/ uracil transketolase: N,N-dimethylglycine PuuE: puuE 6 4-methyl-3- PRPP 2'-deoxycytidine RUTHE_RS02105 kinase: a [protein]- an O - a guanine 46 a [protein]-L- L-malic trans-2- RUTHE_RS07285 orotate nucleoside- phosphoribosyltransferase: hypoxanthine RUTHE_RS02465 transaminase: cob(II)alamin carbamoyl 3-sulfocatechol a holo [PedD acyl- sn-glycerol 3-hydroxyacyl- a (9Z)-3-oxohexadec- CDP-diacylglycerol a 3-sn-phosphatidyl- RUTHE_RS15440 allantoate L-cysteine methylguanine L-ornithine in tRNA proline (ω = 180) semialdehyde oxoadipate- decenoyl-ACP diphosphate kinase: RUTHE_RS02065 phosphoribosyltransferase: hpt [+ 2 isozymes] dimethylglycine N-acetyl-D- RUTHE_RS12945 ATP phosphate carrier protein] GTP 3-phosphate ACP dehydratase 9-enoyl-[acp] biosynthesis I L-serine nucleoside deaminase: transketolase: tkt succinate in DNA tRNA peptidylprolyl aldehyde glycerol-3- enol-lactone isomerase: fabA orotate RUTHE_RS14460 UMP dehydrogenase: glucosamine ACP S- 3-oxoadipate FabZ: fabZ 3-oxoacyl- phosphatidylserine RUTHE_RS03130 butanoyl-CoA semialdehyde (guanosine(46)-N7) isomerase: : dehydrogenase phosphate phosphoribosyltransferase: GMP D-sedoheptulose D-glyceraldehyde RUTHE_RS13260 6-phosphate catechol 2,3- malonyltransferase: enol- 3-hydroxyacyl- [acyl-carrier- DHAP decarboxylase: cytidine deaminase: (d)CMP kinase: NAD-dependent L-carnitine degradation I methylated-DNA-- ornithine -methyltransferase RUTHE_RS02960 RUTHE_RS15410 (NADP(+)): dehydrogenase: bifunctional 3- RUTHE_RS13490 dATP dCMP 7-phosphate 3-phosphate acyl-CoA N-acetylglucosamine- cob(I)yrinic acid dioxygenase: fabD lactonase: ACP dehydratase protein] glycerol-3- RUTHE_RS07290 RUTHE_RS02045 RUTHE_RS02520 succinate- [protein]-cysteine S- carbamoyltransferase: 7 TrmB: trmB [+ 4 isozymes] [+ 2 isozymes] RUTHE_RS14565 RUTHE_RS00840 hydroxydecanoyl- (d)CMP kinase: dehydrogenase: sarcosine 6-phosphate (S)-ureidoglycolate a,c-diamide RUTHE_RS02265 a malonyl- an N - a [protein]-L- pcaD FabZ: fabZ phosphate methyltransferase: 46 4-methyl-3- ACP dehydratase/ reductase: an L-1- UMP kinase: semialdehyde L-carnitine adenosyltransferase: argF [PedD acyl- methylguanine ω c-di-GMP (S)-malate DHAP dehydrogenase: orotidine 5'- RUTHE_RS02520 transaldolase: tal RUTHE_RS13510 deacetylase: RUTHE_RS08635 proline ( = 0) oxoadipate trans-2- a (2E,5Z)-tetradeca- fabG phosphatidylethanolamine 2'-deoxyuridine RUTHE_RS03950 RUTHE_RS08655 dehydrogenase: ureidoglycolate cobO (2Z,4E)-2- carrier protein] in tRNA a (3R,9Z)-3- RUTHE_RS10060 phosphate dCDP [+ 3 isozymes] sarcosine oxidase: decenoyl-ACP 2,5-dienoyl-[acp] sn-glycerol UDP RUTHE_RS08990 lyase: hydroxyhexa- sulfite hydroxyhexadec- guanine and guanosine salvage D-erythrose RUTHE_RS11695 D-glucosamine a [protein]-S- isomerase: fabA 3-phosphate orotidine-5'- : nucleoside- F6P crotonyl-CoA NAD-dependent RUTHE_RS14010 adenosylcobalamin a guanine in DNA L-citrulline 2,4-dienedioate 9-enoyl-[acp] nucleoside-diphosphate 4-phosphate 6-phosphate methyl-L-cysteine phosphate RUTHE_RS12080 diphosphate kinase: succinate- triphosphate bifunctional 3- glycerol-3- kinase: RUTHE_RS14460 transketolase: enoyl-CoA gly glyoxylate predicted a (2E)-hex-2-enoyl-[acp] phosphatidylcholine decarboxylase: thymidine RUTHE_RS14460 semialdehyde (R)-carnitinyl-CoA hydroxydecanoyl- phosphate CMP dUMP guanosine glyoxylate cycle RUTHE_RS02465 hydratase: allantoin degradation crotonobetainyl- ABC biosynthesis VI pyrF UTP serine dehydrogenase: choline choline a (5Z)-tetradec-5-enoyl-[acp] ACP dehydratase/ acyltransferase: dCTP purine-nucleoside transketolase: tkt caiD α to glyoxylate III CoA transporter thymidine kinase: -D-glucosamine RUTHE_RS14135 2503 34 a thiocarboxylated a peptide with trans-2- RUTHE_RS13120 a CDP- UMP CMP phosphorylase: hydroxymethyltransferase: hydratase: caiD adenine a uridine (4S)-4-hydroxy-2- D-glucopyranose a [protein]- pyridoxamine of choline choline RUTHE_RS12080 xanthine and D-glyceraldehyde (S)-3- 6-phosphate [SAMP] C- an N-terminal a holo [PedN acyl- [DNA] D-threo-isocitrate benzaldehyde beta-ketoacyl- decenoyl-ACP diacylglycerol (d)CMP kinase: RUTHE_RS09435 succinate acetyl-CoA RUTHE_RS13225 in 23S rRNA in tRNA oxoheptanedioate 6-phosphate L-histidine 5'-phosphate glycerol-3- (d)CMP kinase: xanthosine salvage 3-phosphate hydroxybutanoyl-CoA (S)-(+)-allantoin succinate terminal glycine Xaa-L-proline carrier protein] DNA polymerase III NADP-dependent glucose-6- aldehyde ACP synthase isomerase: fabA RUTHE_RS02520 CTP guanine pyridoxamine phosphate 1-O- RUTHE_RS02520 CDP (S)-3- ser allantoinase ACP S- subunit gamma/tau: isocitrate phosphate dehydrogenase : a hexanoyl-[acp] II: fabF phosphatidylcholine/ γ 2,4-dihydroxyhept-2- 5'-phosphate 3-hydroxyacyl- acyltransferase UMP kinase: glyoxylate hydroxybutanoyl- PuuE: puuE -butyrobetainyl- crotonobetainyl- 23S rRNA tRNA 2- malonyltransferase: RUTHE_RS08120 dehydrogenase: dehydrogenase: (NADP(+)): RUTHE_RS08425 phosphatidylserine nucleoside- xanthine xanthosine L-carnitine degradation II (adenine(2503)-C(2) leucyl enedioate aldolase: oxidase: pdxH beta-ketoacyl- a (7Z)-3-oxo- ACP PlsY: plsY RUTHE_RS03950 dTMP isocitrate lyase/PEP CoA threonine/serine F6P allantoate CoA CoA thiouridine(34) fabD [+ 4 isozymes] RUTHE_RS04490 zwf RUTHE_RS14565 a [protein]- a 1-acyl-sn synthase: diphosphate kinase: adenine and phosphoribosyltransferase: malate synthase G: )-methyltransferase aminopeptidase: RUTHE_RS06090 a malonyl[PedN ACP synthase hexadec-7-enoyl-[acp] dehydratase purine-nucleoside mutase family protein: dehydrogeanse: dehydratase: synthase a nucleoside 5'- 6-phospho D- N-phospho- PLP -glycerol 3- RUTHE_RS07285 UDP RUTHE_RS14460 dTMP kinase: tmk adenosine RUTHE_RS14970 RUTHE_RS03780 RlmN: rlmN RUTHE_RS07410 acyl-carrier 2-oxoglutarate benzoate II: fabF 3-oxoacyl-[acyl- FabZ: fabZ phosphorylase: RUTHE_RS12980 RUTHE_RS11045 RUTHE_RS02360 L-carnitine MnmA: mnmA monophosphate glucono-1,5-lactone L-histidine phosphate salvage VI hypoxanthine protein] carrier-protein] nucleoside- CTP RUTHE_RS09435 isocitrate lyase: aceA carnitine 3- succinate a (2E,9Z)-hexadeca- 1-acyl-sn-glycerol- dTDP phosphoribosyltransferase: hpt xanthine acetoacetyl-CoA L-serine ammonia- a peptide with pyruvate a 3-oxooctanoyl-[acp] reductase: fabG a phosphatidylcholine diphosphate kinase: urea degradation II crotonobetainyl- dehydrogenase: a 2-methyladenine 2503 34 a proteinogenic semialdehyde 2,9-dienoyl-[acp] 3-phosphate adenosine lyase: RUTHE_RS12015 (S)-ureidoglycine 5'-deoxyadenosine a [SAMP] C- a 2-thiouridine an N-terminal RUTHE_RS14460 nucleoside- xanthine CoA reductase: RUTHE_RS13285 in 23S rRNA met terminal glycine in tRNA amino acid 3-oxoacyl-[acyl- a (3R,7Z)-3-hydroxy- acyltransferase: gln diphosphate kinase: GMP acetyl-CoA C- 3-dehydrocarnitine L-proline UTP : phosphoribosyltransferase: D-threo-isocitrate (S)-malate 2-aminoprop-2-enoate (S)-ureidoglycine RUTHE_RS13280 carrier-protein] hexadec-7-enoyl-[acp] RUTHE_RS04590 RUTHE_RS14460 acyltransferase: urea a 1,2-diacyl- RUTHE_RS08645 RUTHE_RS14970 aminohydrolase: reductase: fabG RUTHE_RS13365 urease subunit bifunctional 3- sn-glycerol dTTP 4-aminobutanoate RUTHE_RS14015 AMP [+ 2 isozymes] gamma: an N-terminal an L-phenylalanyl- a [protein]- a DNA methyl 2-hydroxy-4-oxobutane- UDP a (3R)-3- hydroxydecanoyl- a palmitoleoyl-[acp] 3-phosphate XMP malate degradation III dihydrolipoamide a holo [BryP acyl- D-ala thr an aldehyde a DNA segment RUTHE_RS10025 arginyl-[protein] Phe L-cysteine phosphotriester 1,2,4-tricarboxylate ACP dehydratase/ dehydrogenase: mdh (S)-ureidoglycolate [tRNA ] carrier protein] hypoxanthine vitamin B12- hydroxyoctanoyl-[acp] CTP acetyl-CoA 2-iminopropanoate ammonium trimethylaminoacetone pyruvate aldehyde trans-2- 4-aminobutanoate ACP S- D-alanine--D- threonine/serine dependent recombinase 3-hydroxyacyl- ureidoglycolate dehydrogenase xanthine dehydrogenase decenoyl-ACP 4-aminobutyrate- methylated-DNA-- 4-carboxy-4-hydroxy- malonyltransferase: alanine ligase: dehydratase: ribonucleotide RecA: recA ACP dehydratase lyase: leucyl/phenylalanyl- complex dehydrogenase (NADP(+)): isomerase: fabA a CDP- cis-aconitate oxaloacetate -2-oxoglutarate [protein]-cysteine S- 2-oxoadipate fabD RUTHE_RS03630 RUTHE_RS02360 reductase: FabZ: fabZ RUTHE_RS14010 tRNA--protein dihydrolipoamide a malonyl- small subunit: xdhA RUTHE_RS14565 RUTHE_RS14625 a DNA segment 3-hydroxyacyl- palmitoleate diacylglycerol transaminase: methyltransferase: aldolase/oxaloacetate transferase: acetyltransferase: [BryP acyl- 6,8- D-alanyl-D-alanine 2-oxobutanoate a carboxylate in reverse bifunctional 3- ACP dehydratase RUTHE_RS12945 RUTHE_RS08635 decarboxylase: ligK dUDP Biosynthesis pyruvate succinate glyoxylate glycine betaine RUTHE_RS05785 RUTHE_RS02925 carrier protein] dihydroxypurine orientation hydroxydecanoyl- FabZ: fabZ ACP dehydratase/ semialdehyde S-acetyldihydrolipoamide a (2E,7Z)-hexadeca- L-phenylalanyl-L- a [protein]-S- trans-2- Calvin-Benson-Bassham cycle : Phe [DNA] oxaloacetate pyruvate GDP-mannose biosynthesis CMP-3-deoxy-D- a tRNA methyl-L-cysteine decenoyl-ACP 2,7-dienoyl-[acp] dTDP-L-rhamnose RUTHE_RS04940 arginyl-[protein] manno-octulosonate isomerase: fabA CDP-diacylglycerol biosynthesis acetyl-CoA Degradation/Utilization/Assimilation - Other (5Z)-dodecenoate CO D-glucopyranose biosynthesis citrate biosynthesis II 2 α succinate biosynthesis I 6-phosphate D-ribulose -D-glucopyranose a (2E)-oct-2-enoyl-[acp] D-ribulose-1,5- ribulose 1,5- glucose-6- an N-terminal a [protein]-S- a uridine 34 UDP a (3R)-3- DHAP 5-phosphate 1-phosphate octane oxidation an L-phenylalanyl- 2-oxoadipate acetyl-CoA a holo [BryU acyl- ethylphosphate a uridine in tRNA DNA with lesion bisphosphate bisphosphate phosphate D-arabinose glucose-1-phosphate acrylonitrile L-lysyl-[protein] Phe sulfanyl-L-cysteine in tRNA purine vitamin B12- a (7Z)-hexadec-7-enoyl-[acp] hydroxydecanoyl- glycerol-3- [tRNA ] acetyl-CoA carboxylase: carrier protein] excinuclease carboxylase isomerase: 5-phosphate thymidylyltransferase degradation I alkaline tRNA dependent [acp] 3-hydroxyacyl- phosphate RUTHE_RS02730 ACP S- : ABC subunit large subunit: RUTHE_RS12205 isomerase: RfbA: rfbA NADH xanthine phosphatase: dihydrouridine ribonucleotide beta-ketoacyl- ACP dehydrogenase: dTDP-α-D-glucose tRNA 2- 2-oxoglutarate malonyltransferase: RUTHE_RS10145 UvrB: uvrB RUTHE_RS12720 glucose-6- RUTHE_RS01565 acrylonitrile leucyl/phenylalanyl- acetyl-CoA carboxylase dehydrogenase RUTHE_RS07785 synthase reductase: ACP synthase dehydratase RUTHE_RS10060 aldehydo-D- tRNA--protein thiouridine(34) dehydrogenase biotin carboxylase fabD DusB: dusB [+ 2 isozymes] phosphate dTDP-glucose 4,6- Carbohydrate Degradation a malonyl- small subunit: xdhA sphingosine RUTHE_RS14625 an octanoyl-[acp] II: fabF FabZ: fabZ sn-glycerol arabinose 5- transferase: synthase E1 component: subunit: accC ethanol a 5,6-dihydrouridine DNA without 3-phosphate isomerase: phosphate dehydratase: rfbB MnmA: mnmA RUTHE_RS09370 [BryU acyl- 8-hydroxypurine 1-phosphate in tRNA dUDP lesion a (9Z)-3-oxo- bifunctional 3- RUTHE_RS05545 dTDP-4-dehydro-6- RUTHE_RS05785 malonyl-CoA carrier protein] beta-ketoacyl- glycerol-3- D-ribulose 3-phospho- D-arabinose degradation I fucose degradation a reduced acrylamide octadec-9-enoyl-[acp] hydroxydecanoyl- ribose-5- F6P deoxy-α-D-glucopyranose Entner-Doudoroff shunt D-xylose octane ACP synthase 5-phosphate (R)-glycerate rubredoxin 34 ACP dehydratase/ phosphate phosphate degradation I L-phenylalanyl- a [protein]- a 2-thiouridine II: fabF 3-oxoacyl-[acyl- dTDP-4- amidase: Phe CO glutaryl-CoA NADH acyltransferase: β a tRNA 2 carrier-protein] trans-2- isomerase mannose-1-phosphate D-arabinofuranose dehydrorhamnose D-arabinopyranose -L-fucopyranose D-gluconate RUTHE_RS08370 L-lysyl-[protein] L-cysteine in tRNA RUTHE_RS13120 alkane 1- reductase: fabG decenoyl-ACP RpiA: rpiA guanylyltransferase/ 5-phosphate 3,5-epimerase: rfbC 6-phosphate D-xylose a 3-oxodecanoyl-[acp] D-ribose 5- L-fucose isomerase/ monooxygenase: isomerase: fabA glycerol-3- ribulose- mannose-6- dTDP-4-dehydro- phosphogluconate acrylate a (3R,9Z)-3-hydroxy- a (2E)-dec- phosphate related protein: RUTHE_RS08450 3-oxoacyl-[acyl- phosphate 1-O- phosphate 3- phosphate isomerase: β-L-rhamnose dehydratase: 5-methoxy-6- (S)-5-amino-3- a 2-(all-trans- dCDP octadec-9-enoyl-[acp] 2-enoyl-[acp] transketolase: RUTHE_RS02460 NaMN acetyl-CoA O-succinyl-L- (S)-mandelate 4-methylcatechol sphinganine N5-CAIR carrier-protein] acyltransferase epimerase: RUTHE_RS09825 α-L-fucopyranose RUTHE_RS03585 D-xylulose melibiose degradation alkane 1- methylbenzimidazole oxohexanoate polyprenyl)phenol Ins(1)P thr RUTHE_RS02465 dTDP-4- homoserine vitamin B12- reductase: fabG bifunctional 3- bifunctional 3- PlsY: plsY D-xylulose rpe D-mannopyranose KDO-8P D-ribulose monooxygenase: mandelate racemase/ catechol 2,3- 5-(carboxyamino) 13-DPG dehydrorhamnose xylulokinase: sphingosine kinase: inositol L-threonine 3- dependent hydroxydecanoyl- hydroxydecanoyl- a 1-acyl-sn 5-phosphate transketolase: tkt 6-phosphate L-fucose isomerase/ KDGP RUTHE_RS02185 muconate lactonizing 2-polyprenylphenol dioxygenase: imidazole a (3R)-3- reductase: rfbD xylB melibiose nicotinate-nucleotide-- 3-keto-5- RUTHE_RS10145 monophosphatase: dehydrogenase: ribonucleotide ACP dehydratase/ ACP dehydratase/ -glycerol 3- D-sedoheptulose related protein: enzyme family protein: 6-hydroxylase: ubiB RUTHE_RS02265 ribonucleotide hydroxydecanoyl-[acp] β dimethylbenzimidazole aminohexanoate O-succinylhomoserine RUTHE_RS00495 reductase: trans-2- trans-2- phosphate transketolase: 7-phosphate dTDP- -L-rhamnose RUTHE_RS02460 xylulokinase: RUTHE_RS00530 a 3-(all-trans (2Z,4E)-2-hydroxy- RUTHE_RS07045 mutase: purE xylB alpha-glucosidase/ 1-octanol phosphoribosyltransferase: cleavage protein: sulfhydrylase: metZ sphinganine RUTHE_RS14625 3-hydroxyacyl- decenoyl-ACP decenoyl-ACP 1-acyl-sn-glycerol- RUTHE_RS02465 sedoheptulose D-ribulose bifunctional [+ 3 isozymes] -polyprenyl) 5-methyl-6-oxohexa- myo-inositol aminoacetone CAIR α-D-mannose α L-fuculose alpha-galactosidase: cobT RUTHE_RS12850 1-phosphate CDP ACP dehydratase isomerase: fabA isomerase: fabA 3-phosphate transketolase: tkt bisphosphatase: -Kdo 1-phosphate 4-hydroxy-2- D-xylulose (R)-mandelate benzene-1,2-diol 2,4-dienoate FabZ: fabZ acyltransferase: glpX 1-phosphate oxoglutarate 5-phosphate RUTHE_RS13180 3-hydroxyacyl- a (3Z)-dec- 3-deoxy-manno- 5-methoxy-6- bifunctional 3- RUTHE_RS04590 D-sedoheptulose mannose-1-phosphate aldolase/2- (S)-3- L-homocysteine succinate ACP dehydratase 3-enoyl-[acp] a 1,2-diacyl- D-glyceraldehyde octulosonate methylbenzimidazole nicotinate acetoacetate hydroxydecanoyl- long-chain fatty F6P 1,7-bisphosphate guanylyltransferase/ dehydro-3-deoxy- D-galactopyranose D-glucopyranose 1-octanal aminobutanoyl-CoA FabZ: fabZ sn-glycerol 3-phosphate cytidylyltransferase: L-fuculose ribotide phosphate ACP dehydratase/ beta- acid activation triose-phosphate mannose-6- phosphogluconate a (2E,9Z)-octadeca- 3-phosphate RUTHE_RS01625 glycolaldehyde 1-phosphate trans-2- ketoacyl- fructose-1,6- class I fructose- isomerase: phosphate isomerase: DHAP aldolase: eda 1-octanal 2,9-dienoyl-[acp] a long-chain bisphosphate dehydrogenase: decenoyl-ACP ACP bisphosphatase: RUTHE_RS13530 RUTHE_RS09825 CMP-Kdo a [protein]- dCDP fatty acid UDP-α-D-glucose a monocarboxylic π synthase acyl-CoA aldolase: GDP-α-D- D-glyceraldehyde RUTHE_RS05050 5-methoxybenzimidazole NaMN a protein with glutathione coenzyme A a phytosphingosine an adenine in DNA a cytosine in DNA Ins(2)P N -phospho- CAIR isomerase: fabA RUTHE_RS00805 triose-phosphate biosynthesis I pyruvate D-mannose degradation acid amide vitamin B12- II: fabF a CDP- synthetase: RUTHE_RS02945 mannose 3-phosphate a disulfide bond type I restriction- DNA cytosine L-histidine 5-(carboxyamino) [+ 2 isozymes] isomerase: octanoate inositol dependent a (2E)-dec-2-enoyl-[acp] a (5Z)-3- diacylglycerol RUTHE_RS04825 D-glucopyranose glycolate DHAP (S)-lactaldehyde sphingosine kinase: modification methyltransferase: amidase: phosphohistidine imidazole a long-chain RUTHE_RS00815 D-mannopyranose nicotinate-nucleotide-- monophosphatase: ribonucleotide oxododec- β-D-fructose 1,6- 6-phosphate acyl-CoA CoA pyrophosphatase: RUTHE_RS10145 system subunit M: RUTHE_RS13560 RUTHE_RS08370 phosphatase: ribonucleotide an oleoyl-[acp] fatty acyl-CoA DHAP alpha-D-glucose 6-phosphate dimethylbenzimidazole RUTHE_RS00495 reductase: 5-enoyl-[acp] bisphosphate mannose-1-phosphate synthetase: glutaredoxin RUTHE_RS10310 RUTHE_RS11430 [+ 2 isozymes] RUTHE_RS11290 mutase: purE 3-oxoacyl- phosphate-specific guanylyltransferase/ phosphoribosyltransferase: a phytosphingosine an N 6 -methyladenine a 5-methylcytosine a [protein]- RUTHE_RS14625 RUTHE_RS04825 3: grxC a monocarboxylate myo-inositol AIR [acyl-carrier- phosphoglucomutase: mannose-6- cobT 1-phosphate in DNA in DNA L-histidine CDP protein] α-D-glucopyranoseRUTHE_RS03360 phosphate isomerase: a protein with 3',5'-ADP 4'-phosphopantetheine a decanoyl-[acp] reductase: 1-phosphate RUTHE_RS09825 AMP GSSG PRPP biosynthesis fructose- 5-methoxybenzimidazole nicotinate reduced L- octanoyl-[acyl-carrier fabG F6P beta-ketoacyl- a (3R,5Z)-3- bisphosphate UTP--glucose- ribotide phosphate cysteine residues protein] biosynthesis ACP synthase hydroxydodec- D-ribose 5- aldolase class II: 1-phosphate (mitochondria, yeast) phosphate RUTHE_RS00800 uridylyltransferase: Carboxylate Degradation II: fabF 5-enoyl-[acp] ribose-phosphate RUTHE_RS01620 lysine within a [protein]- a [protein]- bifunctional 3- class I fructose- adenosyl-cob(III) sn-glycerol τ an acetoacetyl-[acp] pyrophosphokinase: 5-hydroxybenzimidazole NaMN an octanoyl-[acp] a ribonucleic acid phytosphingosine a sphingoid base oxaloacetate N -phospho- N-phospho- (S)-malate a 3-oxododecanoyl-[acp] hydroxydecanoyl- bisphosphate α pyruvate decarboxylation to acetyl CoA gcv protein H yrinate a,c-diamide 3-phosphate 3-oxoacyl-[acyl- RUTHE_RS03200 UDP- -D-glucose propanoyl CoA 4-carboxy-4-hydroxy- L-histidine L-histidine class II carrier-protein] ACP dehydratase/ PRPP aldolase: sphingosine kinase: sphingosine kinase: cobyric acid L-glyceraldehyde phosphohistidine phosphohistidine 3-oxoacyl-[acyl- a [pyruvate degradation I 2-oxoadipate fumarate reductase: fabG trans-2- RUTHE_RS02945 nicotinate-nucleotide-- RUTHE_RS10145 RUTHE_RS10145 synthase: 3-phosphate phosphatase: phosphatase: carrier-protein] a (3R)-3- dehydrogenase lipoyl(octanoyl) ribonuclease PH: aldolase/oxaloacetate RUTHE_RS00505 hydratase: decenoyl-ACP propanoyl-CoA dimethylbenzimidazole reductase: mgrA RUTHE_RS11290 RUTHE_RS11290 reductase: fabG hydroxybutanoyl-[acp] E2 protein] N 6 transferase RUTHE_RS10720 decarboxylase: ligK L-glyceraldehyde fumC isomerase: fabA pyruvate acyl-CoA phosphoribosyltransferase: phytosphingosine a sphingoid adenosylcobyrate a [protein]- a [protein]- -lipoyl-L-lysine LipB: lipB pyruvate 3-phosphate fumarate a (3R)-3- 3-hydroxyacyl- 3-hydroxyacyl- Amino Acid Biosynthesis dehydrogenase carboxylase cobT (C18) 1-phosphate 1-phosphate L-histidine L-histidine hydroxydodecanoyl-[acp] ACP dehydratase (acetyl- a [glycine-cleavage ACP dihydrolipoyl subunit beta: a nucleoside a ribonucleic acid FabZ: fabZ dehydratase L-histidine biosynthesis transferring) RUTHE_RS06435 acyl-carrier H protein] 3-hydroxyacyl- superpathway of branched chain amino acid biosynthesis L-arginine biosynthesis II (acetyl cycle) dehydrogenase: (S)-methylmalonyl- 5-hydroxybenzimidazole diphosphate bifunctional 3- FabZ: fabZ L-arginine biosynthesis I (via L-ornithine) E1 component nicotinate N 6 -octanoyl-L-lysine ACP dehydratase uracil degradation lpdA CoA ribotide phosphate hydroxydecanoyl- subunit D-gluconate FabZ: fabZ a (2E,5Z)-dodeca- PRPP I (reductive) Inorganic Nutrient Metabolism ACP dehydratase/ pyruvate alpha: pdhA methylmalonyl- degradation bifunctional 3- 3,5-dienoyl-[acp] thr glu N-acetylglutamyl-phosphate pyruvate uracil a [pyruvate a [pyruvate CoA α hydroxydecanoyl- trans-2- ATP dehydrogenase D-threo-7,8- 6-O-cis-keto- 6-O- -mycolyl- acetolactate dihydropyrimidine dehydrogenase dehydrogenase epimerase: mce D-gluconate urea cycle 3-methyl-2- 5,10-methylene- a single- 2-heptaprenylphenol 2-hydroxyisobutyramide chloroacetaldehyde reduced riboflavin betaine aldehyde a quinone ACP dehydratase/ decenoyl-ACP phosphoribosyltransferase threonine/serine complex sulfite dihydroneopterin mycolyl-trehalose trehalose 6- synthase bifunctional dehydrogenase: 6 6 oxobutanoate tetrahydromethanopterin stranded RNA isomerase: fabA regulatory subunit: dehydratase: E2 protein] N dihydrolipoamide E2 protein] N -S- (R)-methylmalonyl- gluconokinase: oxidation I aldehyde 6-phosphate phosphate trans-2- small glutamate N- : argB preA nitrite/sulfite betaine-aldehyde NADPH:quinone RUTHE_RS05330 RUTHE_RS02360 bifunctional glutamate N- -dihydrolipoyl- acetyltransferase: acetyldihydrolipoyl- CoA RUTHE_RS10490 2-polyprenylphenol amidase: dehydrogenase trehalose- trehalose- decenoyl-ACP a (5Z)-dodec- subunit: ilvN acetyltransferase/ D-gluconate arg dihydroneopterin reductase: dehydrogenase: reductase: a (2E)-but-2-enoyl-[acp] acetyltransferase/amino- 5,6-dihydrouracil L-lysine RUTHE_RS02925 L-lysine methylmalonyl- Arginase/agmatinase/ sulfite Ketopantoate polyribonucleotide 6-hydroxylase: ubiB RUTHE_RS08370 (NADP(+)): phosphatase: phosphatase: isomerase: fabA 5-enoyl-[acp] ATP (2Z)-2-aminobut- amino-acid 6-phosphate aldolase: RUTHE_RS14385 betB RUTHE_RS13360 acid acetyltransferase CoA formimionoglutamate assimilatory sulfite hydroxymethyltransferase: : pnp RUTHE_RS14565 otsB otsB phosphoribosyltransferase: 2-enoate (S)-2-acetolactate acetyltransferase 3-(all-trans-heptaprenyl) 2-hydroxy-2- α α acyl-CoA/acyl-ACP ArgJ: argJ hydantoinase mutase: scpA hydrolase arginase sulfate reduction III dehydrogenase: RUTHE_RS09100 RUTHE_RS01290 riboflavin glycine betaine a semiquinone trehalose-cis-keto- , '-trehalose a (2E)-dodec-2-enoyl-[acp] RUTHE_RS05325 ArgJ: argJ benzene-1,2-diol methylpropanoate 2-chloroacetate α dehydrogenase: ketol-acid glu N-acetyl-L-glutamate N-acetyl-L-glutamate 5-semialdehyde B/oxoprolinase family: RUTHE_RS02820 soxC [+ 2 isozymes] mono-mycolate 6- -mycolate succinyl-CoA RUTHE_RS13280 1-(5-phospho- reductoisomerase: N-acetyl-L- family protein: acetyl-CoA sulfate sulfate a nucleoside a single- β arginase: rocF 6-(hydroxymethyl) glycolaldehyde -D-ribosyl)-ATP ilvC glutamate RUTHE_RS09040 diphosphate stranded RNA a butanoyl-[acp] 2-iminobutanoate -7,8-dihydropterin phosphoribosyl-ATP (2R)-2,3- N-acetylornithine [+ 3 isozymes] argininosuccinate ammonium 2-dehydropantoate THMPT stearate biosynthesis diphosphatase: dihydroxy-3- acetylglutamate bifunctional glutamate N- aminotransferase: beta-ketoacyl- II (bacteria and plants) acetyltransferase/amino- lyase: argH APS a dodecanoyl-[acp] RUTHE_RS15945 methylbutanoate kinase: argB gln RUTHE_RS12945 3-ureidopropanoate glutamine-hydrolyzing ACP synthase β acid acetyltransferase L-arginino-succinate L-ornithine carbamoyl-phosphate phosphoadenylyl- a [glycine-cleavage α 1-(5-phospho- - 2,3-dihydroxy- N-acetylglutamyl- RNase R degradation S-(2-hydroxyacyl) a negatively a supercoiled a phosphate GDP- -D- II: fabF a palmitoyl-[acp] ArgJ: argJ synthase small sulfate reductase: complex H protein] 2-nonaprenylphenol uroporphyrinogen-I GGPP chorismate D-ribosyl)-AMP 2-oxobutanoate isovalerate phosphate glutamine-hydrolyzing a sulfurated [sulfur carrier] SAM RNA glutathione supercoiled DNA duplex DNA monoester mannose beta-ketoacyl- beta-ketoacyl- N-acetyl-L-ornithine argininosuccinate subunit: carA 6 GDP- phosphoribosyl- dehydratase: carbamoyl-phosphate RUTHE_RS14390 N -octanoyl-L-lysine uroporphyrinogen DNA replicative ACP synthase a 3-oxohexanoyl-[acp] ACP synthase synthase: 2-polyprenylphenol chorismate mutase: alkaline mannose 4,6- AMP acetolactate RUTHE_RS13045 synthase small subunit: carA decarboxylase: phytoene synthase: topoisomerase DNA : II: fabF II: fabF β-alanine RUTHE_RS10685 carbamoyl phosphate sulfite 6-hydroxylase: ubiB RUTHE_RS07085 phosphatase: dehydratase: 3-oxoacyl-[acyl- a 3-oxooctadecanoyl- cyclohydrolase: synthase 3-methyl-2- L-ornithine degradation ribonuclease hydroxyacylglutathione RUTHE_RS08750 RUTHE_RS05610 IV subunit B: parE RUTHE_RS00375 laurate carbamoyl phosphate L-ornithine ornithine lipoyl RUTHE_RS07785 gmd carrier-protein] [acp] hisI small oxobutanoate N-acetyl-L- I (L-proline biosynthesis) assimilatory sulfite R: rnr hydrolase: gloB 3-(all-trans-nonaprenyl) a single carbamoyltransferase: synthase: lipA coproporphyrinogen I a relaxed DNA prephenate GDP-4-dehydro- acyl-CoA reductase: fabG 1-(5-phospho-β-D-ribosyl)- subunit: ilvN glutamate 5- reductase (NADPH) 15-cis-phytoene an alcohol α a 3-oxotetradecanoyl-[acp] 3-oxoacyl- argF benzene-1,2-diol stranded DNA -D-rhamnose synthetase: 5-[(5-phosphoribosylamino) (S)-2-aceto-2- isopropylmalate/ branched-chain semialdehyde L-ornithine : RUTHE_RS14385 a (3R)-3- [acyl-carrier- hydrogencarbonate N-acetylornithine a nucleoside 5'- a 2-hydroxy 3-oxoacyl-[acyl- RUTHE_RS04825 methylideneamino]imidazole- hydroxybutanoate homocitrate/ amino acid ornithine a [glycine-cleavage a diribonucleotide glutathione hydroxyhexanoyl-[acp] protein] aminotransferase: L-citrulline hydrogen sulfide 5'-deoxyadenosine complex H protein] an unsulfurated monophosphate carboxylate carrier-protein] reductase: 4-carboxamide ketol-acid citramalate aminotransferase: glutamine- ornithine cyclodeaminase: met lauroyl-CoA 3-hydroxyacyl- RUTHE_RS12945 N 6 -lipoyl-L-lysine [sulfur carrier] reductase: fabG fabG 1-(5-phosphoribosyl)-5- reductoisomerase: synthase: RUTHE_RS12460 hydrolyzing carbamoyltransferase: argF RUTHE_RS08880 ACP dehydratase [(5- phosphoribosylamino) RUTHE_RS06910 N-acetyl-L- a (3R)-3- a (3R)-3- ilvC carbamoyl- ornithine FabZ: fabZ methylideneamino]imidazole-4- ornithine hydroxytetradecanoyl-[acp] hydroxyoctadecanoyl- (R)-2,3-dihydroxy- phosphate cyclodeaminase: a [ E2 adenine 1518 / 6,8- bifunctional 3- carboxamide isomerase: hisA (2S)-2- val Amino Acid Degradation fumarate 2-decaprenylphenol 3-methylcatechol 5,6-dihydrouracil prephenate propionamide a D-hexose NAD + [acp] 3-methylpentanoate synthase acetylornithine RUTHE_RS04080 a sulfurated [sulfur carrier] SAM protein] N 6 -octanoyl-L-lysine asp adenine 1519 in 16S rRNA dihydroxypurine 3-hydroxyacyl- hydroxydecanoyl- 3-hydroxyacyl- isopropylmalate pro phosphoribulosylformimino- 2,3-dihydroxy-3- small deacetylase: 16S rRNA catechol 2,3- xanthine NAD-dependent prephenate glucokinase: ACP dehydratase ACP dehydratase/ ACP 3-isopropylmalate L-citrulline 2-polyprenylphenol amidase: NAD kinase: AICAR-phosphate methylvalerate subunit: carA argE L-leucine degradation I (adenine(1518)-N(6)/ dioxygenase: dehydrogenase dihydropyrimidine dehydratase: RUTHE_RS04635 FabZ: fabZ trans-2- dehydratase dehydratase: L-histidine L-glutamate L-arginine degradation L-citrulline degradation adenine(1519)-N(6))- 6-hydroxylase: ubiB RUTHE_RS08370 RUTHE_RS13230 decenoyl-ACP hydro-lyase: carbamoyl degradation II VII (arginase 3 pathway) L-aspartate oxidase: RUTHE_RS02265 small subunit: xdhA dehydrogenase RUTHE_RS08745 bifunctional 3- FabZ: fabZ leuD leuC L-ornithine argininosuccinate synthase: degradation VI lipoyl synthase: lipA RUTHE_RS11835 dimethyltransferase subunit PreA: preA D-hexose 6- imidazole RUTHE_RS13045 phosphate 3-(all-trans-decaprenyl) (2Z,4E)-2-hydroxy-6- 3-phenyl-2- + hydroxydecanoyl- isomerase: fabA RUTHE_RS10685 leu (to pyruvate) RsmA: rsmA urate propanoate NADP bifunctional 3- glycerol (S)-3-methyl-2- 3-isopropylmalate L-citrulline N 6 -dimethyladenine 1518 benzene-1,2-diol oxohepta-2,4-dienoate uracil oxopropanoate phosphate ACP dehydratase/ branched-chain his arg hydroxydecanoyl- phosphate oxopentanoate dehydratase L-tryptophan biosynthesis ornithine /N 6 -dimethyladenine 1519 trans-2- a (2E)-hex-2-enoyl-[acp] ornithine L-arginino-succinate amino acid histidine glu ACP dehydratase/ synthase small subunit: leuD glycine biosynthesis II carbamoyltransferase: a [pyruvate dehydrogenase 2-iminosuccinate succinate in 16S rRNA decenoyl-ACP branched-chain carbamoyltransferase: aminotransferase: ammonia- 5'-deoxyadenosine acyl-CoA/acyl-ACP trans-2- subunit argF met E2 protein] N 6 -lipoyl-L-lysine an unsulfurated [sulfur carrier] isomerase: fabA amino acid 2-isopropylmaleate argF chorismate argininosuccinate RUTHE_RS12460 lyase: hutH Arginase/agmatinase/ carbamoyl dehydrogenase: decenoyl-ACP HisH: hisH lyase: argH a [glycine-cleavage 4-methyl-2- aminotransferase: 6 urocanate formimionoglutamate phosphate RUTHE_RS13280 isomerase: fabA complex H protein] N - oxopentanoate a (2E)-tetradec-2-enoyl-[acp] RUTHE_RS12460 3-isopropylmalate glycine aminomethyl- hydrolase D-erythro-1- aminomethyldihydrolipoyl- urocanate glutamine- a (2E)-octadec- AICAR dehydratase: L-homoserine asp L-citrulline arg cleavage transferring (2S, 3S)-3- arginase family: 1-(3-sn-phosphatidyl)- a 3,5,7,9,11,13,15- (R)-3- an organic phosphoenol a hexanoyl-[acp] (imidazol-4- L-lysine hydratase: hydrolyzing uroporphyrinogen-III 4-guanidinobutyramide D-glucopyranose D-ribofuranose ferroheme o 2-enoyl-[acp] ile leuD leuC biosynthesis system glycine methylaspartate RUTHE_RS02820 L-serine degradation asp CAIR sn-glycerol 3-phosphate hepta-oxo- hydroxybutanoate molecule pyruvate yl)-glycerol anthranilate protein dehydrogenase: RUTHE_RS05395 carbamoyl- hexadecanoyl-[PKS-acp] glucose 1- beta-ketoacyl- 3-isopropylmalate arginase: rocF aldo/keto reductase: uroporphyrinogen-III 3-hydroxybutyrate : 3-phosphate argininosuccinate GcvH: gcvH gcvP isovaleryl-CoA 4-imidazolone- phosphate phosphatidylglycerophosphatase amidase: dehydrogenase: heme A synthase: cytochrome P450: pyruvate ACP synthase dehydratase asp RUTHE_RS03685 C-methyltransferase: dehydrogenase: RUTHE_RS10700 imidazoleglycerol- synthase: gly 5-propanoate synthase ser A: RUTHE_RS04330 RUTHE_RS08370 RUTHE_RS01205 RUTHE_RS04575 RUTHE_RS13535 kinase: pyk II: fabF phosphate small subunit: leuD [+ 2 isozymes] [+ 2 isozymes] isovaleryl-CoA phosphoribosylaminoimidazolesuccinocarboxamide aldo/keto reductase: cobA RUTHE_RS04185 a myristoyl-[acp] : RUTHE_RS10685 urea small threonine/serine D-glucono- D-ribofuranose dehydratase (2R,3S)-3- dehydrogenase: mesaconate L-ornithine synthase: RUTHE_RS05710 an L-1-phosphatidyl- 9-hydroxy-3,5,7,11,13,15-RUTHE_RS04655 a stearoyl-[acp] RUTHE_RS15130 N-(5- subunit: carA dehydratase: precorrin-2 4-guanidinobutanoate acetoacetate 1,5-lactone 5-phosphate ferroheme a an alcohol pyruvate beta-ketoacyl- a 3-oxooctanoyl-[acp] HisB: hisB L-proline biosynthesis isopropylmalate superpathway of L-serine a [glycine-cleavage a [glycine-cleavage RUTHE_RS13345 sn-glycerol hexaoxohexadecanoyl- L-aspartyl- L-arginino- phosphoribosyl) ornithine RUTHE_RS02360 3-(imidazol-4- I (from L-glutamate) 6 [PKS-acp] ACP synthase 4-phosphate succinate -anthranilate and glycine biosynthesis I complex H protein] complex H protein] N 3-methylcrotonyl- N-formimino- carbamate 3-oxoacyl-[acyl- yl)-2-oxopropyl 6 cyclodeaminase: L-serine II: fabF N -lipoyl-L-lysine -dihydrolipoyl-L-lysine CoA SAICAR carrier-protein] phosphate argininosuccinate 3-phospho- L-glutamate RUTHE_RS08880 ammonia-lyase: glu aspartate- acetyl/propionyl/ a 3-oxohexadecanoyl-[acp] reductase: fabG histidinol-phosphate (2S)-2-isopropyl- semialdehyde lyase: argH (R)-glycerate (S)-citramalate ornithine 2-aminoprop-RUTHE_RS12015 stearate glutamate 5-kinase: phosphoglycerate methylcrotonyl- a (3R)-3- transaminase: 3-oxosuccinate dehydrogenase: 1-(2- cyclodeaminase: 2-enoate dehydrogenase: CoA carboxylase 10 1915 α-L- 3-oxoacyl-[acyl- RUTHE_RS06740 RUTHE_RS04620 arg carboxyphenylamino) RUTHE_RS04080 CO 5-amino-4- 4a-hydroxy-N - a pseudouridine cytidine (2S)- hydroxyoctanoyl-[acp] acyl-CoA γ-L-glutamyl RUTHE_RS07610 RUTHE_RS09910 aminomethyl- 2 PRPP 2-octaprenylphenol oxaloacetate D-glucopyranose L-idonate -1-deoxy-D-ribulose subunit alpha: citramalate imidazolecarboxyamide formyltetrahydrofolate in 23S rRNA rhamnopyranose ethylmalonyl-CoA carrier-protein] synthetase: L-histidinol 5-phosphate transferring N-formyl- nucleoside deaminase: 3-hydroxyacyl- fatty acid elongation -- saturated L-aspartate 4- 5-phosphate phosphoglycerate RUTHE_RS06415 synthase: 4a-hydroxytetrahydrobiopterin 23S rRNA glucose 1- L-rhamnose methylmalonyl- L-idonate 5- reductase: fabG RUTHE_RS04825 phosphate glycine L-glutamate pro 2-polyprenylphenol citrate synthase: RUTHE_RS03130 ACP dehydratase glutamate-5- 4-methyl-2- semialdehyde indole-3- dehydrogenase: 3-methylglutaconyl- RUTHE_RS05620 dehydratase: (pseudouridine(1915)- dehydrogenase: mutarotase: CoA dehydrogenase: dehydrogenase: N-formylglutamate 2-iminopropanoate adenine 6-hydroxylase: ubiB RUTHE_RS04940 cytidine deaminase: a (3R)-3- FabZ: fabZ semialdehyde oxopentanoate homoserine glycerol RUTHE_RS07020 CoA isopropylmalate/ RUTHE_RS08525 N(3))-methyltransferase RUTHE_RS01205 RUTHE_RS08815 epimerase: mce RUTHE_RS11800 stearoyl-CoA phosphoribosyltransferase: RUTHE_RS02045 β hydroxyhexadecanoyl-[acp] an acetoacetyl-[acp] phosphate 3-phosphooxypyruvate gcvP amidohydrolase: 10 RlmH: rlmH -L- bifunctional 3- dehydrogenase: branched-chain dehydrogenase: homocitrate/ L-methionine degradation RUTHE_RS02015 an N -formyl- an N 3 - 3-(all-trans-octaprenyl) 1,2-dihydroxypropane- D-glucono- (2R)- 5-dehydro- synthase [+ 3 isozymes] RUTHE_RS08075 uridine rhamnopyranose 3-hydroxyacyl- hydroxydecanoyl- RUTHE_RS04615 amino acid RUTHE_RS05980 citramalate I (to L-homocysteine) 7,8-dihydrofolate methylpseudouridine 1915 benzene-1,2-diol 1,2,3-tricarboxylate 1,5-lactone ethylmalonyl-CoA D-gluconate TrpC: trpC phosphoserine N-formylglutamate ACP dehydratase ACP dehydratase/ histidinol L-glutamate-5- aminotransferase: (1S,2R)-1- transaminase: synthase: in 23S rRNA FabZ: fabZ trans-2- RUTHE_RS12460 L-homoserine amidohydrolase: RUTHE_RS06910 AICAR histidinol semialdehyde C-(indol-3- RUTHE_RS07015 HMG-CoA met pyruvate decenoyl-ACP RUTHE_RS14835 methionine bifunctional 3- dehydrogenase: yl)glycerol isomerase: fabA a 3-oxoacyl-[acp] leu O-phospho- adenosyltransferase: hydroxydecanoyl- hisD L-cysteine biosynthesis I 3-phosphate glu acetate pyruvate L-serine RUTHE_RS02500 UDP-N-acetyl- 5,6- ACP dehydratase/ tryptophan (S)-2,3,4,5- D-glucosamine a uridine 55 a (2E)-oct-2-enoyl-[acp] histidinol phosphatidylglycerolphosphate α D-altropyranose L-iditol acetoacetate L-idonate trans-2- (S)-1-pyrroline- synthase SAM -D-glucosamine tetrahydrodipicolinate 6-phosphate in tRNA dihydrothymine dehydrogenase: alanine acetoacetate L-tryptophan (1-oleoyl, 2-palmitoyl) decenoyl-ACP 5-carboxylate ser subunit UDP-N-acetylglucosamine 4-hydroxy- phosphoglucosamine tRNA L-fucose isomerase/ NAD-dependent L-iditol 2- acetoacetate L-idonate 5- acyl-CoA/acyl-ACP hisD racemization serine O- degradation I isomerase: fabA pyrroline-5- beta: trpB phosphatidylglycerophosphatase 1-carboxyvinyltransferase: tetrahydrodipicolinate mutase: pseudouridine(55) related protein: dihydropyrimidine dehydrogenase: decarboxylase: dehydrogenase: dehydrogenase: acetyltransferase: (via anthranilate) histidinal carboxylate L-glutamine ser L-arginine degradation III A: RUTHE_RS04330 murA reductase: RUTHE_RS01300 synthase TruB: truB RUTHE_RS02460 dehydrogenase RUTHE_RS10505 RUTHE_RS08810 RUTHE_RS11800 RUTHE_RS13280 3-oxoacyl-[acyl- cysE ser UDP-N-acetyl-α-D- a (2E)-hexadec-2-enoyl-[acp] biosynthesis I ala indole (arginine decarboxylase/ RUTHE_RS14910 α-D-glucosamine 55 subunit PreA: preA 5-dehydro- carrier-protein] reductase: O-acetyl-L-serine trp 1-oleoyl-2-palmitoyl- glucosamine-enolpyruvate (2S,4S)-4-hydroxy-2,3,4,5- a pseudouridine keto-D-psicose keto-L-sorbose histidinol alanine serine agmatinase pathway) SAH 1-phosphate thymine acetone D-gluconate an octanoyl-[acp] beta-ketoacyl- reductase: fabG RUTHE_RS12065 L-glutamine phosphatidylglycerol tetrahydrodipicolinate in tRNA dehydrogenase: glu racemase: hydroxymethyltransferase: ACP synthase tryptophan degradation I arg hisD pro glutamine alr cysteine synthase RUTHE_RS13225 II: fabF D-ala synthase adenosylhomocysteinase: N-Formyl-L- a 2,3,4-saturated a (3R)-3-hydroxyacyl- histidinol synthetase: A: RUTHE_RS07720 kynurenine subunit gln RUTHE_RS10070 fatty acyl-[acp] [acyl-carrier protein]bifunctional 3- dehydrogenase: RUTHE_RS06050 gly a palmitoyl-[acp] beta: trpB Asp-tRNA(Asn) hydroxydecanoyl- hisD [+ 4 isozymes] cys agmatine /Glu-tRNA(Gln) L-homocysteine ACP dehydratase/ gln L-asparagine amidotransferase Arginase/agmatinase/ trans-2- his trp degradation I subunit GatB: gatB formimionoglutamate L-kynurenine decenoyl-ACP [+ 3 isozymes] hydrolase palmitate isomerase: fabA asn glu arginase family: kynureninase: 3-hydroxyacyl- RUTHE_RS02820 asparaginase: acyl-CoA ACP dehydratase RUTHE_RS07965 L-alanine kynU synthetase: [+ 2 isozymes] degradation IV FabZ: fabZ asp RUTHE_RS04825 anthranilate a 2,3,4-saturated acyl-CoA/acyl-ACP a trans-2-enoyl- putrescine ala palmitoyl-CoA fatty acyl-[acp] dehydrogenase: [acyl-carrier protein] RUTHE_RS13280 alanine dehydrogenase: ald pyruvate a branched- a reduced a reduced chain plastocyanin amino acid plastocyanin an amino an oxidized acid molybdate an oxidized an a sugar 6- a sugar 6- plastocyanin an amino an amino an amino a C4- a C4- a C4- a carbohydrate a carbohydrate spermidine thiosulfate a microcin queuosine a tricarboxylate a tricarboxylate plastocyanin a lipopolysaccharide an amino ammonium a nucleotide a siderophore benzoate oligopeptide phosphate phosphate acid acid acid dicarboxylate dicarboxylate dicarboxylate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate putrescine predicted a lipopolysaccharide acid chromate a polysaccharide ABC predicted predicted transporter cytochrome- predicted ABC ABC predicted ABC predicted ABC ABC cytochrome RS03470 RS09265 RS08730 RS12430 of a RS12880 RS12875 RS00225 RS11055 c oxidase, efflux transporter of RS01580 RS09575 transporter RS06680 RS11675 RS11725 RS12870 RS08335 RS14065 RS00400 RS10515 RS00595 RS00735 RS15015 RS14535 transporter of transporter of RS01235 RS07200 RS09975 RS08575 RS03575 RS10710 RS13320 RS00090 RS06210 transporter c oxidase branched- cbb3-type a lipopolysaccharide of an a carbohydrate a carbohydrate of molybdate chain amino acid thiosulfate an a microcin queuosine amino acid a tricarboxylate a tricarboxylate a sugar a sugar an amino an amino an amino a C4- a C4- a C4- a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate a carbohydrate spermidine ammonium a nucleotide a siderophore benzoate oligopeptide a lipopolysaccharide acid acid an amino acid dicarboxylate dicarboxylate dicarboxylate a carbohydrate a carbohydrate putrescine chromate a polysaccharide molybdate O O 2 a lipopolysaccharide an amino acid a branched- 2 H O H O 2 acid chain 2 amino acid This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.