6Th Student Retreat Booklet
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6th Student retreat of the Microbiology and Immunology PhD program 12-14 September 2013 Locarno, Switzerland Kontaktgruppe für Forschungsfragen Table of Contents Table of Contents ..................................................... 2 Scientific Program .................................................... 3 Guests ...................................................................... 5 Abstracts .................................................................. 9 Presentations: ......................................................................................... 9 Session 1 ................................................................................................... 9 Session 2 ................................................................................................ 12 Session 3 ................................................................................................ 15 Posters: .................................................................................................... 19 Session 1 ................................................................................................ 19 Session 2 ................................................................................................ 35 Social Event - Winetasting ...................................... 51 General Information ............................................... 53 Contacts ................................................................. 54 Participants ............................................................ 54 2 Scientific Program Thursday, 12 September 2013 11:00 – 11:30 Arrival and Welcome 17:30 – 18:30 Guest speaker: Prof. Antonio Lanzavecchia, MD Institute for Research in Biomedicine, Bellinzona 20:00 – 22:00 Poster Session 1 Friday, 13 September 2013 8:00 – 10:00 Workshop “Presentation Skills” by Janneke van Woerden 10:30 – 12:30 Workshop “Presentation Skills” 14:00 – 15:00 Guest speaker: Prof. Urs Albrecht Department of Biology & Biochemistry University of Fribourg 15:30 – 16:30 Guest speaker: Dr. Santiago Gonzalez Institute for Research in Biomedicine, Bellinzona 16:30 – 18:00 Student presentations, Session 1 (3 students) 19:30 – 21:30 Poster Session 2 3 Saturday, 14 September 2013 9:00-10:30 Student presentations, Session 2 (3 students) 11:00 – 12:00 Student presentations, Session 3 (3 students) 14:45 Departure 4 Guests Prof. Antonio Lanzavecchia, MD Immune Regulation Director Via Vela, 6 6500 Bellinzona, Switzerland [email protected] +41 91 820 0310 +41 91 820 0305 Antonio Lanzavecchia earned a degree in Medicine at the University of Pavia where he specialized in Paediatrics and in Infectious Diseases. From 1983 to 1999, he worked at the Basel Institute for Immunology and since 1999 he is the Director of the Institute for Research in Biomedicine in Bellinzona. He taught immunology at the Universities of Genova and Siena and since 2009 is Professor of Human Immunology at the Swiss Federal Institute of Technology ETH Zurich. He is Member of the EMBO and Fellow of the Royal College of Physicians. Awarded the EMBO medal in 1988 and the Cloëtta prize in 1999, Antonio Lanzavecchia published more than 270 papers. His research has covered several aspects of immunology: from antigen processing and presentation to dendritic cell biology, from lymphocyte activation and trafficking to T and B cell memory. 5 Dr. Santiago Gonzalez Infection and Immunity Group Leader Via Vela, 6 6500 Bellinzona, Switzerland [email protected] +41 91 820 0360 +41 91 820 0305 Santiago F. González holds two PhD degrees, one in microbiology from the University of Santiago de Compostela (Spain) and one in immunology from the University of Copenhagen (Denmark). From January 2007 to September 2011 he was a postdoc in the group of Michael Carroll at the Immune Disease Institute, Harvard Medical School, in Boston (USA). He has been awarded two EU Marie Curie Fellowships, one for his postgraduate studies in Denmark where he studied skin inflammation and the connection between innate and adaptive responses from a molecular perspective. The second fellowship was a Marie Curie International Outgoing Fellowship awarded in 2008 for a project shared between Harvard Medical School and the National Center for Biotechnology (Madrid). The project focused on the study of the defense mechanism against Influenza virus. He has published several papers related with antigen trafficking, memory B cell, and the regulation of the immune system in high impact journals. During his work at Harvard he studied the transport mechanism of an influenza vaccine in the lymph node. He found that dendritic cells residing in the lymph node medulla use the lectin receptor SIGN-R1 to capture lymph-borne influenza virus and promote humoral immunity. These results have important implications for the 6 generation of durable humoral immunity to viral pathogens through vaccination and were published in Nature Immunology. In November 2012 he joined the Institute for Research in Biomedicine in Bellinzona as a group leader studying pathogen- host interaction. Prof. Urs Albrecht Department of Biology & Biochemistry, University Fribourg Chemin du Musée 5 CH-1700 Fribourg [email protected] +41 26 300 8636 +41 26 300 9735 Urs Albrecht studied at the University of Zurich and got his diploma in Biochemistry in 1988. He earned his PhD in 1993 under the supervision of Prof. D. Schümperli in the Department of Zoology at the University of Bern. Afterwards he did a postdoc at the Department of Biochemistry at the Baylor College of Medicine in Houston, USA, with Prof. G. Eichele. In 1998 he was got a position as assistant professor at the same institute and from 1999-2001 at the Max-Planck Institute for Experimental Endocrinology in Hannover, Germany. Since 2001 he is an associate professor at the department of biochemistry at the University of Fribourg in Switzerland where he studies circadian rhythms in mammals. From 2008-2011 he was head of biochemistry Unit of the department of medicine at the University of Fribourg. 7 Dr. Janneke van Woerden [email protected] Janneke van Woerden studied Biology at the University of Utrecht and did her master’s degree in animal biology at the same university. She obtained her PhD in Anthropology in 2011 from the University of Zurich. She trained with Pamela Alean, who offers courses in transferable skills (e.g. project management, oral and poster presentations, career development, supervision of students) for researchers and teachers at institutions of higher education. Outline of the workshop "Effective scientific presentations": Learning outcomes By the end of the course the participants will be able to… - prepare and give an oral or a poster presentation about their research work in an effective manner for the specific target audience - recognize the elements of best practice when they observe the presentations of others Content - Elements of professional research presentations: audience orientation; objectives of the presentation; structure; preparation and delivery; personal performance; use of body language and mimic - Design of powerful posters; oral presentations of the posters - Effective use of power point for oral presentations. 8 Abstracts Presentations: Session 1 Identification of new therapeutic targets to modulate lymphatic vessel function Erica Russo, Alvaro Sanchez Teijeira, Maximilian Nitschké, Maria Iolyeva, Ann-Helen Willrodt, David Aebischer, Simone Häner, and Cornelia Halin Institute of Pharmaceutical Sciences, ETH Zurich Wolfgang-Pauli Strasse 10, Zurich [email protected] Afferent lymphatic vessels are present in most tissues, where they begin as blind-ended capillaries, which merge into larger collecting vessels that connect with draining lymph nodes (LNs). Afferent lymphatic vessels are essential for the maintenance of tissue fluid homeostasis, absorption of dietary fatty acids (in the intestine) and mediate the trafficking of immune cells. Dysfunction of the lymphatic vasculature may contribute to the pathogenesis of human diseases: For example, lymphedema is a condition caused by damaged lymphatics resulting in an accumulation of lymph fluid and tissue swelling. Lymphatic vessels may also serve as a conduit to LNs and thereby are involved in systemic metastasis of cancer cells. Moreover, recent evidence suggest that lymphatic vessels are also involved in the regulation of tissue inflammation. An important goal of our research is to identify and validate new molecules, which could serve as therapeutic targets to modulate lymphatic vessel function and immune responses. In particular, we are interested in investigating the molecular mechanisms that control the migration of leucocytes, 9 particularly dendritic cells, into and within lymphatic vessels. Furthermore, we are currently studying molecular mediators that are involved in (lymph)angiogenesis and lymphatic drainage. For this, we use standard molecular and cell biology methods, mouse models of inflammation and leukocyte migration, as well as intravital microscopy. In addition, we frequently employ FACS analysis, FACS-sorting and transcriptional profiling. MCMV-specific T Cell Immunity in Glandular Tissue Jenny Thom, Annette Oxenius ETH Zürich - Institute of Microbiology Wolfgang-Pauli-Strasse 10 CH-8093 Zürich [email protected] Cytomegaloviruses (CMVs) are ubiquitous β-herpesviruses that establish lifelong infection and latency. Prolonged secretion of virus in saliva represents a major route of CMV transmission with acinar glandular epithelial cells