[NUTRACEUTICALS]

by Linda Milo Ohr

Nutrition on the Move

they provide has been shown to be as bioavailable as calcium from milk. PURACAL PP is specifically devel- oped for calcium fortification of beverages and contains 14% of cal- cium L-lactate. On average, an adult human body is able to absorb only about 30% of the calcium consumed, while the rest is discharged, unused. A dose of PURACAL PP can increase the bioavailability of calcium in the final product application by up to 50%, says Schinck. PURACAL XP was specially developed for application in challenging formulations that require extremely high solubility, including syrups and in-line blending. PURACAL XP is also ideal for prod- ucts demanding high stability such as grape juice or carbonated beverages. FruiteX-B ® Calcium Fructoborate from FutureCeuticals, Momence, Ill., Exercise and diet can help to keep muscles, bones, and joints healthy. Photo courtesy of DuPont Nutrition & Health (www.futureceuticals.com), is a pat- ented plant mineral complex shown to aid in joint and bone support. The ones, joints, and muscles are effects on bone health. ingredient has been shown to modu- important for proper movement Calcium is the most common min- late key markers such as C-reactive Band structure of our bodies. The eral found in the human body, protein (CRP) associated with the health and maintenance of these are accounting for 1.5% of its composi- body’s inflammatory response mech- important for adults, especially Baby tion. One of the most important and anism. Age-related inflammation has Boomers and athletes, and children. widely recognized benefits of this been linked to bone health. From vitamins and minerals to pro- essential mineral, which is commonly Information in a FutureCeuticals teins and glucosamine, nutritional found in bones and teeth, is bone white paper discussed a double- ingredients are available to help keep health, says Hans Schinck, Category blind, placebo-controlled study on people of all ages moving. Manager at Corbion Purac, Diemen, healthy subjects and FruiteX-B. the Netherlands (www.purac.com). Results showed that taking 108 mg of Bone Health To meet growing consumer calcium fructoborate twice per day Calcium and vitamin D are most com- demand, Corbion Purac has devel- for 14 days reduced CRP by 37%. monly associated with bone health. oped a range of calcium ingredients Calcium fructoborate supplementa- In the past several years, prebiotics for food and beverage manufactur- tion also induced a 19% increase in such as inulin and oligofructose have ers. The company’s PURACAL® endogenous levels of calcitriol, the also been shown to benefit bones by ingredients, which contain forms of active form of vitamin D-3. aiding in the absorption of calcium, calcium lactate and gluconate, are “For a nutrient we’ve heard about an important bone mineral. Other highly soluble, making them ideal for since we were children, the amount ingredients, too, have beneficial beverage fortification. The calcium of research and interest in the health pg 60 07.14 • www.ift.org benefits of vitamin D is quite high metabolism. PLT Health Solutions glucosamine is a vegetarian-sourced today,” says Barbara Davis, Director, offers MenaQ7 ™, a natural form of ingredient produced in the United Medical & Scientific Affairs at PLT vitamin K-2 (menaquinone-7, or States. It is self-affirmed GRAS for Health Solutions Inc., Morristown, MK-7). MenaQ7 provides the MK-7 use in specified foods in the U.S. N.J. (www.plthealth.com). “What’s form of vitamin K-2 as a fermentation “Mechanistically, there was an more, data from the NHANES study, extract whereby vitamin K-2 is manu- article published in 2013 that sup- 2005–2008, indicate that 94% of U.S. factured using Bacillus licheniformis, ported the hypothesis that adults are not consuming adequate providing soy-free production. MK-7 glucosamine activates the cellular amounts of vitamin D, causing it to be is recognized in scientific literature housekeeping process of autoph- classified as a ‘shortfall’ nutrient by for providing optimal activity and agy,” explains Fleagle. Autophagy is the U.S. Dept. of Agriculture. To vitamin K status in the body. an important mechanism to keep assist consumers in choosing foods KoACT ® from AIDP Inc., City of cells healthy, especially in tissues that will increase their vitamin D Industry, Calif. (www.aidp.com), is a that have low turnover, such as carti- intake, the proposed Nutrition Facts patented collagen-based compound lage. “There are two recent studies panel requires vitamin D labeling for designed for advanced bone in Japan looking at cartilage bio- the first time.” strength. The ingredient’s collagen markers in healthy athletes. More Recently, PLT Health Solutions, formula delivers more than bone min- holistically, there were two recent and Oakshire Naturals LP, Kennett eral density; it provides a strong, Square, Pa. (oakshirenaturals.com), flexible, and fibrous protein network Fortification of juices with calcium is a popular way for beverage manufacturers announced the launch of Earthlight that supports bone structure and to help consumers get more bone-building calcium in their diets. Whole Food Vitamin D. The patented helps bone withstand daily impact. © tiverylucky/iStock/Thinkstock mushroom powder ingredient deliv- KoACT benefits bone health by both ers 40,000 International Units of increasing bone synthesis and reduc- vitamin D per gram from a non-GMO, ing bone resorption, shifting the bone clean-label, natural source. White metabolism to a more youthful level. button and Portobello mushrooms Tart cherries have been linked to are exposed to light through a propri- arthritis and muscle recovery thanks etary process to naturally enhance to their anthocyanin content. vitamin D content. The ingredient’s Research presented at the 2013 high concentration of vitamin D will Experimental Biology annual confer- allow food, beverage, and supple- ence indicated that tart cherries ment producers to offer ‘”Good,” could also help support strong bones “Excellent,” and “High Potency” (Cherry Marketing Institute, 2013). source label claims with only a few Researchers at Oklahoma State milligrams of the ingredient. The University found that adding ingredient is manufactured by Montmorency tart cherries to the Oakshire Naturals, a division of diet reduced age-related bone loss in Pennsylvania-based Oakshire mice by increasing bone density and Mushrooms. showing signs of increased bone- The body needs to optimize the building during aging. use of calcium because excess cal- cium, or calcification, will occur Joint Health within the blood vessel walls, making Glucosamine is still the most widely them stiff and less elastic. Vitamin used and discussed joint health K-2 is important because it helps ingredient, says Mike Fleagle, Brand keep the excess calcium out of the Manager Regenasure® Glucosamine, arteries and mediates the synthesis at Cargill, Minneapolis, Minn. (www. of proteins that regulate bone cargill.com). Cargill’s Regenasure

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publications from the University of revealed a statistically significant Washington from epidemiological increase of proteoglycan density in studies that showed a correlation the medial and lateral tibial regions of between long-term glucosamine use the FORTIGEL-treated subjects com- and reduced inflammation and lon- pared to those in the placebo group, gevity,” says Fleagle. indicating a direct impact on human Methylsulfonylmethane (MSM) is cartilage tissue. known for its benefits in joint health. Nitta Gelatin NA Inc., Morrisville, Bergstrom Nutrition, Vancouver, N.C. (www.nitta-gelatin.com), offers Wash. (www.bergstromnutrition. Wellnex™ collagen peptides made com), offers OptiMSM ®, the only from type I collagen, the same colla- MSM ingredient that is designated as gen found in bones and skin. GRAS and is approved for use in a Information from the company’s wide variety of products, including website describes a double-blind, supplements, nutrition bars, and bev- placebo-controlled study in which erages. Several pre-clinical and Wellnex was shown to assist in clinical studies support the efficacy reducing cartilage degradation and of MSM in supporting joint health increased cartilage regenerations. and range of motion. Research Rousselot, Mukwonago, Wis. Gummy-style candies are fortified with shows that MSM reduces inflamma- (www.rousselot.com, www.peptan. collagen peptides and other ingredients that ® may improve joint health. Photo courtesy of tory markers that damage cartilage com), offers Peptan collagen pep- Rousselot as people age, protecting its tides for joint health. The company’s integrity. latest clinical study demonstrated essential for muscle synthesis and Proteins and amino acids are essential for muscle synthesis and health, whether you health, whether you are focused on are focused on muscle health as a child, growing teenager, adult, athlete, or elder. muscle health as a child, growing teenager, adult, athlete, or elder. GELITA USA, Sergeant Bluff, that Peptan can help to reduce joint Branched-chain amino acid content Iowa (www.gelita.com), offers pain and improve joint function in is stressed among proteins, particu- FORTIGEL® collagen peptides that patients with osteoarthritis larly leucine, for lean muscle. The have been shown to stimulate the (Rousselot, 2013). January 2014 Food Technology arti- growth of new cartilage by stimulat- The double-blind, placebo-con- cle “Proteins Pick Up the Pace” ing cells to help relieve joint pain and trolled study was carried out on 100 addressed the growing number of make the joints smooth and mobile. female subjects between the ages of protein sources like egg, poultry, soy, Orally administered FORTIGEL has 40–70 who had been diagnosed with dairy, rice, wheat, canola, flax, and been shown to be absorbed intesti- osteoarthritis. The subjects were pea that are available. nally and to accumulate in cartilage, randomly assigned 8 g of Peptan or a Reidy et al. (2014) showed that stimulating a statistically significant placebo per day for six months. The using a protein blend of soy, casein, increase of cartilage tissue study confirmed the efficacy of and whey post-workout prolonged metabolism. Peptan to reduce knee joint pain in the delivery of select amino acid net Researchers at Tufts Medical osteoarthritis patients and increase balance across the leg muscle during Center published a study in 2011 that joint function. early post-exercise recovery, sug- investigated the long-term effect of At the 2014 Vitafoods Europe gesting prolonged muscle building FORTIGEL treatment on the composi- exhibition, Rousselot unveiled Bee (DuPont Nutrition & Health, 2014). tion of hyaline cartilage in individuals Healthy™, a gummy-style application The research also showed that using with early knee osteoarthritis that combines the nutritional benefits the protein blend post-workout pro- (McAlindon et al., 2011). Overall, 30 of Peptan collagen peptides and longed the delivery of select amino subjects were randomized into one Olygose pea fibers.Bee Healthy is the acids to the muscle for an hour longer group that received 10 g of FORTIGEL latest delivery concept from the com- than using whey alone. The blend a day for 48 weeks and a control pany, which features ingredients also sustained a greater positive net group that received a placebo. Three such as honey (44%), soluble pea amino acid balance, suggesting there magnetic resonance imaging scans fiber,Peptan collagen peptides (13%), is less muscle protein breakdown of the knee were performed on each porcine gelatine (7%), and vitamin C. during the time period shortly after subject: one at baseline, one at 24 consumption of a blended protein weeks, and one at 48 weeks. The Muscle Health product. analysis of the cartilage scans Proteins and amino acids are The double-blind, randomized pg 62 07.14 • www.ift.org [NUTRACEUTICALS]

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REFERENCES clinical trial included 16 healthy subjects, dupont.com), was shown to improve body Cherry Marketing Institute. 2013. New studies link tart ages 19–30. The protein beverages con- composition in strength-trained men cherries to bone health and improved stroke outcomes. sisted of a soy-dairy blend (25% isolated (DuPont Nutrition & Health, 2013). The Press release, April 23. DuPont™ Danisco ® SUPRO ® soy protein, betaine ingredient improved the body com- DuPont Nutrition & Health. 2013. DuPont Nutrition & 50% caseinate, and 25% whey protein iso- position, performance and power of Health ingredient supports muscle growth in human study. Press release, Nov. 6. late) or a single protein source (whey strength-trained men who consumed the protein isolate). The protein sources were sugar beet extract every day over a DuPont Nutrition & Health. 2014. DuPont, University of Texas Medical Branch study reaffirms soy-dairy protein ingested 1 hour after exercise by the sub- 6-week period. The subjects were 18- to blend extends duration of amino acid delivery to muscles. jects in both groups. Muscle biopsies were 35-year-old men who regularly undertook Press release, April 24. taken at baseline and up to 5 hours after resistance training. During the treatment McAlindon, T.E., Nuite, M., Krishnan, N., Ruthazer, R., resistance exercise. period, the men were required to follow a Price, L.L., Burstein, D., Griffith, J., and Flechsenhar, K. 2011. Change in knee osteoarthritis cartilage detected by Potato proteins are garnering interest strict training program composed of exer- delayed gadolinium enhanced magnetic resonance imaging in the sports nutrition market. PRO GO™ cises commonly performed by weight following treatment with collagen hydrolysate: a pilot ran- domized controlled trial. Osteoarthritis Cartilage 19(4): proteins from Solanic, Veendam, the lifters. Measurements at the end of the 399-405. Netherlands (www.solanic.eu), are study showed an increase in lean muscle Reidy, P.T., Walker, D.K., Dickinson, J.M., Gundermann, extracted from potato using a proprietary mass and reduced body fat percentage in D.M., Drummond, M.J., Timmerman, K.L., Cope, M.B., process. They are rich in branched-chain those who took the betaine. In addition, Mukherjea, R., Jennings, K., Volpi, E., and Rasmussen, B.B. 2014. Soy-dairy protein blend and whey protein inges- amino acids to support muscle synthesis arm size and bench press work capacity tion after resistance exercise increases amino acid transport and arginine to support cardiovascular had increased. FT and transporter expression in human skeletal muscle. J. fitness.PRO GO has also been shown to be Appl. Physiol. doi: 10.1152/japplphysiol.01093.2013. quickly and easily digested. Linda Milo Ohr, Rousselot. 2013. New study supports ability of Peptan® to Derived from sugar beet extract, Contributing Editor, reduce joint pain and improve joint function. Press release, Denver, Colo. ™ Dec. 16. BetaPower Natural Betaine from DuPont • [email protected] Nutrition & Health, St. Louis, Mo. (www.

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