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(12) STANDARD PATENT (11) Application No. AU 2010224615 B2 (19) AUSTRALIAN PATENT OFFICE

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(12) STANDARD PATENT (11) Application No. AU 2010224615 B2 (19) AUSTRALIAN PATENT OFFICE (12) STANDARD PATENT (11) Application No. AU 2010224615 B2 (19) AUSTRALIAN PATENT OFFICE (54) Title Dietary supplement (51) International Patent Classification(s) A23K 1/175 (2006.01) A23K1/18 (2006.01) (21) Application No: 2010224615 (22) Date of Filing: 2010.02.12 (87) WIPONo: WO10/106351 (30) Priority Data (31) Number (32) Date (33) Country 0904584.0 2009.03.17 GB (43) Publication Date: 2010.09.23 (44) Accepted Journal Date: 2014.05.08 (71) Applicant(s) Calinnova Ltd (72) Inventor(s) Green, Malcolm Geoffrey (74) Agent / Attorney Davies Collison Cave, Level 14 255 Elizabeth Street, Sydney, NSW, 2000 (56) Related Art ARNBJERG, J. "Hypokalcaemi hos hest. En kasuistik med diskussion (Hypocalcemia in the horse. A case report)" Nord Vet Med, 1980, Volume 32, Issue 5 Pages 207-211 US 2003/0077254 A1 (RAMAEKERS) 24 April 2003 FR 2625415 A1 (UNICOR UNION COOP AGRICOLES) 07 July 1989 HUDSON, NPH et al., "Primary Hypothyroidism in Two Horses" Australian Veterinary Journal, 1999, Volume 77, Number 8, Pages 504-508 GRUBB, T.L. et al., "Hemodynamic Effects of Calcium Gluconate Administered to Conscious Horses" Journal of Veterinary Internal Medicine, 1996, Volume 10 Number 6 Pages 401-404 US 2008/0014304 A1 (ZELLER et al.) 17 January 2008 ANONYMOUS, "Finish Line Thia-cal" [Retrieved on 23 April 2013] Retrieved from internet <URL: http://www.doversaddlery.eom/finish-line-thia-cal-gallon/p/X1-22069/> published on 30 December 2005 ANONYMOUS, "Humavyte" [Retrieved on 23 April 2013] Retrieved from internet <URL: http://web.archive.org/web/20080719131829/http://www.ranvet.com.au/ liquid_chelated_minerals.htm> published on 19 July 2008 as per Wayback Machine (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2010/106351 Al 23 September 2010 (23.09.2010) PCT (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, A23K1/175 (2006.01) A23K1/18 (2006.01) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, F.G, ES, FI, GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, PCT/GB2010/050231 KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, (22) International Filing Date: ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, 12 February 2010 (12.02.2010) NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, (25) Filing Language: English TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 0904584.0 17 March 2009 (17.03.2009) OB GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, (71) Applicant for all designated Stales except US): VETA- TM), European (AT, BE, BG, CH, CY, CZ, DE, DK, EE, FARM EUROPE LTD [GB/GB]; 21-22 Spring Mill In­ ES, FI, FR, GB, GR, HR, HU, IE, IS, ΓΓ, LT, LU, LV, dustrial Estate, Avening Road, Nailsworth, Gloucester­ MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, shire GL6 OBS (GB). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). (72) Inventor; and (75) Inventor/Applicant for US only): GREEN, Malcolm, Published: Geoffrey [GB/GB]; Vetafarm Europe Ltd, 21-22 Spring — with international search report (Art. 21(3)) Mill Industrial Estate, Avening Road, Nailsworth, Gloucestershire GL6 OBS (GB). — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of (74) Agent: DONALD, Jenny; Forrester House, 52 Bounds amendments (Rule 48.2(h)) Green Road, London, Greater London Nil 2EY (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, llllllllllllllllllllllllllllllllllllllllllllll^ Al 2010/106351 (54) Title: DIETARY SUPPLEMENT (57) Abstract: The present application relates to dietary supplements, in particular, a horse calming supplement comprising a cal­ cium coordinated compound. w o WO 2010/106351 PCT/GB2010/050231 Title: Dietary Supplement 5 DESCRIPTION OF THE INVENTION The present invention relates to a dietary supplement. In particular, the present invention relates to a horse supplement for calming horses. 10 There is a long existing problem that many horses display agitated behaviour and appear to be in a state of anxiety. Such horses often exhibit behavioural problems such as inability to concentrate, difficulty learning and poor sporting performance. It may be that a horse generally demonstrates such agitated 15 behaviour or only does so in certain situations, such as in large crowds or on hearing a loud noise. This can be a particular problem when a horse is taking part in an equestrian sporting event. Other horses may exhibit this behaviour in recreational situations such as 20 hacking or schooling when safety and rider confidence become significant issues. There is a general need to be able to calm horses when they are in such an agitated state. Moreover, there is a further need to ensure that the horse 25 maintains a calm temperament yet still has the ability to concentrate, learn and make split second judgements and decisions. This is of particular importance for horses that take part in equestrian sporting events. Many attempts have been made to improve the temperament of such horses. 30 These attempts include endeavouring to train the horses to maintain a calm temperament in all situations. Although some horses have shown an WO 2010/106351 PCT/GB2010/050231 2 improved temperament with such training, there remain some horses in which little or no improvement is seen. Instead of, or as well as, endeavouring to train a horse, another attempt to 5 improve the temperament of a horse is to alter the nutritional intake of the horse. There are a number of dietary supplements on the market that attempt to deal with these problems that are aimed at calming horses. For example some supplements include magnesium as a calming agent. Such supplements have been shown to improve the temperament of some horses 10 yet provide no or little effect on other horses. It is believed that those horses that have been successfully treated had a magnesium deficiency. Other supplements include tryptophan, B group vitamins and herbs, which have shown little or no improvement in the temperament of some horses. 15 Therefore, it is clear that the temperament of some horses cannot be calmed with the above attempts and there remains a need to improve the temperament of horses in an agitated state. As will be appreciated there is a need to provide new products, compositions 20 or agents which can calm horses, which at least address some of the problems associated with the known products, compositions or agents identified above. It is an object of the present invention to provide such a product, composition or agent. 25 It has surprisingly been found that providing a horse with a supplement comprising a calcium coordination compound, such as chelated calcium, has a drastic effect on the overall temperament of many horses. It has been found that previously agitated horses have a calmer temperament. This effect improves the safety of the rider and the horse, and can increase the rider’s 30 enjoyment. Moreover, it has also been found that horses that train for and take part in equestrian sporting events are more alert, have a better WO 2010/106351 PCT/GB2010/050231 3 concentration and a better reaction time. The latter effect has also been shown for calm horses. The calcium coordination compound when provided in a sufficient amounts 5 leads to a high proportion of the calcium being absorbed into a horse. Chelated calcium has sufficient bioavailability such that an ingestible amount can be provided to a horse and produces the calming effect. A calcium coordination compound is calcium bonded to or associated with one 10 or more ligands. Calcium coordination compounds include calcium chelates, which include calcium bonded to or associated with an organic molecule. The calcium chelate can be bonded to or associated with amino acids, such as methionine, glycine, lysine etc.; carbohydrates such as gluconates, lactates, malates etc.; other organic molecules, such as citrate, ascorbate, acetate etc; 15 and/or derived or concentrated from milk. The calcium chelate may be selected from the following non-exhaustive list: calcium citrate, calcium gluconate, calcium citrate malate, calcium malate, calcium lactate, a calcium amino acid chelate, calcium aspartate, calcium 20 ascorbate dihydrate, calcium aspartate, calcium boro gluconate, calcium bromolactobionate hexahydrate, calcium citratehydrate, calcium D-saccharate, calcium glubionate, calcium gluconate, calcium lactate gluconate, calcium lactobionate, calcium levulinate dihydrate, calcium magnesium lactate gluconate, calcium orotate dihydrate, calcium fumarate, calcium lactate, 25 calcium succinate and/or calcium pidolate. The calcium coordination compound may be bonded to or associated with protein, such as whey protein, casein, soy protein, pea protein, and cereal protein or other plant, algal, yeast, fungal, bacterial or animal derived proteins. H:\scg\Ii!lcnvmeii\NRPOrlbl\DCC\SCGW()7J‘l52_].doc-3/04/2014 4 2014 The calcium may be deliberately incorporated at high levels in living organisms such as plants, algae, yeasts, fungi, bacteria or single celled or multicellular Apr animals. 03 5 In a first aspect of the present invention, there is provided a horse calming supplement comprising, consisting essentially of, or consisting of a calcium coordination compound.
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