Jarrow® QUICKReference Guide FORMULAS healthy living through science & education Glucosamine + Chondroitin + MSM Supports Joint Health*

Glucosamine + Chondroitin + MSM Combination provides efficacious quantities of Glucosamine Sulfate, Chondroitin Sulfate, and MSM combined with Vitamin C and Manganese for joint health.*

PRODUCT CATEGORY Joint

Who Can Benefit From this Product? Supplement Facts Serving Size 4 Capsules Anyone with suboptimal joint function who wants to promote joint Amount Per Serving % DV mobility, flexibility, and comfort may find this product beneficial.* Vitamin C 60 mg 100% Manganese 1 mg 50% Glucosamine Sulfate • 2 KCI 2000 mg * Yielding: Glucosamine Sulfate 1500 mg What Distinguishes this Product? Potassium Chloride 500 mg Chondroitin Sulfate (low molecular weight) 1200 mg * • Sodium-Free Glucosamine Sulfate (from 1333 mg Chondroitin Sulfate Sodium) Methylsulfonylmethane 300 mg * • 1.5 g Glucosamine Sulfate and 1.2 g Chondroitin Sulfate Per Serving (providing 102 mg of organic sulfur) - Quantities consistent with clinical research * Daily Value not established. • Also Contains Vitamin C and Manganese Other Ingredients - Needed in the synthesis of collagen and cartilage Magnesium stearate (vegetable source), cellulose, and silicon dioxide. Capsule consists of gelatin. Contains: Shellfish (shrimp). No wheat, no gluten, no soybeans, no dairy, no egg, How Does Each Active Ingredient Function in no fish, no peanuts/tree nuts. this Product? Suggested Usage Glucosamine Stimulates proteoglycan production found in joint Take 4 capsules per day, or as directed by your qualified health care consultant. Sulfate cartilage* Chondroitin Attracts shock-absorbing fluid to proteoglycans* Note MSM A sulfur source for inclusion in joints* Do NOT use if allergic to shellfish. If you have a medical condition, are pregnant, lactating, or trying Vitamin C Needed for synthesis of collagen* to conceive, are under the age of 18, or are taking medications, consult your health care practitioner Manganese Needed for synthesis of cartilage* before using this product.

ORDER CODE: GCM120 BOTTLE SIZE: 120 CAPSULES ORDERING INFORMATION ORDER CODE: GCM240 BOTTLE SIZE: 240 CAPSULES

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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group receiving the placebo had progressive joint space narrowing, Glucosamine while the those receiving chondroitin showed no change in mean + Chondroitin + MSM joint space width.* It is often suggested that there are three requirements to keep cartilage Methyl Sulfonyl Methane (MSM) healthy: water for lubrication, proteoglycans to attract and hold the Methylsulfonylmethane (MSM) is a naturally occurring, sulfur- water, and collagen to keep the proteoglycans in place. Proteoglycans containing compound that is both present in body fluids and tis- are large molecules made of protein and carbohydrates. They hold sues and is found in milk, fruits, vegetables, and grains (in small water like a sponge helping to make cartilage resilient. amounts). Animal research has shown that joints with lower levels of cartilage also have low sulfur content. In one animal study, the Glucosamine effect of prolonged oral administration of MSM was examined in Glucosamine is a major building block of the water-loving relation to joint health. It was found that MSM was capable of pro- proteoglycans. Not surprisingly, the very presence of glucosamine moting joint health.* stimulates the production of more proteoglycans. The fact that glucosamine increases the synthesis of these key elements of cartilage In a preliminary double-blind trial in human subjects with suboptimal indicates that it may actually help repair cartilage.* In fact, for many joint function, daily supplementation with MSM promoted joint comfort years glucosamine has been successfully used for supporting and after six weeks. In a separate placebo-controlled trial, researchers promoting healthy joint cartilage repair and maintenance. This has studied 50 men and women who also had suboptimal joint function. been demonstrated by experimental as well as clinical studies, in These men and women were given MSM daily or a placebo for 12 which glucosamine led to functional joint improvement.* weeks. The MSM group showed significant increases in comfort and physical function when compared to the placebo group.* Several studies have shown that besides stimulating the production of cartilage, glucosamine may significantly help to improve suboptimal Vitamin C and Manganese joint function.* Patients taking glucosamine for up to 3 years seem Vitamin C’s role in collagen formation and the health of connective to have significantly less knee joint degeneration, less joint space tissue is well known. In addition, vitamin C consumption seems narrowing, and significant symptom improvement when compared to mitigate the risk of cartilage loss in people with suboptimal joint with placebo. In one study of 1,208 patients supplemented with function. Manganese is the preferred cofactor of enzymes called glucosamine, pain improved steadily throughout the treatment, and glycosyltransferases; these enzymes are required for the synthesis of 95% of the patients enjoyed a positive response. Glucosamine even proteoglycans that are needed for the formation of healthy cartilage continued to work 6-12 weeks after usage had stopped. Many clinical and bone.* trials show that taking glucosamine supports functionality compared to placebo, but other trials do not find such conclusive results.* Jarrow Formulas® Glucosamine + Chondroitin + MSM combination provides efficacious quantities of glucosamine sulfate, chondroitin Chondroitin sulfate, and MSM combined with vitamin C and manganese Although usually studied independently, some reports have indicated for optimizing joint health.* Glucosamine + Chondroitin + MSM that glucosamine and chondroitin work synergistically. Chondroitin combination utilizes a sodium free form of GS stabilized with only is the perfect complement to glucosamine since chondroitin acts like potassium chloride (KCl). For best results, use with JarroSil™, the a biological version of a “liquid magnet,” attracting fluid into proteo- biologically Activated Silicon™. glycans. This fluid acts as a shock absorber and also brings nutrients with it into the cartilage. Perhaps of greater significance than its fluid- enhancing properties, chondroitin protects existing cartilage through References its modulatory effects on enzymes that degrade cartilage. Further- Available upon request more, like glucosamine, chondroitin stimulates the production of pro- teoglycans and collagen that are needed for healthy new cartilage.*

In one randomized, double-blind, placebo-controlled trial, the effectiveness of chondroitin was evaluated for promoting joint health in the knee. In this study, 300 human subjects were given either 1200 mg chondroitin or placebo once per day for 2 years. The

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

For more information visit www.jarrow.com