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1 Control of the physical and antimicrobial skin barrier by an IL-31 – IL-1 signaling 2 network* 3

4 Kai H. Hänel,†,‡,**,|| Carolina M. Pfaff,†,‡,** Christian Cornelissen,†,‡,|| Philipp M. Amann,†,|| 5 Yvonne Marquardt,† Katharina Czaja,† Arianna Kim,§ Bernhard Lüscher,‡,¶ and Jens M. 6 Baron,†,¶

8 †Department of Dermatology and ‡Institute of Biochemistry and Molecular Biology, Medical 9 School, RWTH Aachen University, 52074 Aachen, Germany; §Department of Dermatology, 10 Columbia University, College of Physicians and Surgeons, New York, NY, U.S.A. 11 **K.H.H. and C.M.P. are cofirst authors. 12 ¶B.L. and J.M.B. are cosenior authors.

13 ||Present addresses: Chiltern International GmbH, Norsk-Data-Strasse 1, 61352 Bad Homburg 14 v.d.H., Germany (KHH); Novartis Pharma GmbH, Roonstr. 25, 90429 Nürnberg, Germany 15 (CC); Department of Dermatology, SLK Hospital Heilbronn, 74078 Heilbronn, Germany 16 (PMA) 17 *This work was supported by the Deutsche Forschungsgemeinschaft (BA 1803/7-1) and the 18 START program of the Medical School of the RWTH Aachen University to CC, BL and JMB. 19 20 Author to whom correspondence should be addressed 21 Bernhard Lüscher 22 Institute of Biochemistry and Molecular Biology 23 RWTH Aachen University 24 Pauwelsstraße 30 25 52074 Aachen, Germany 26 Phone: +49 (0)241-8088850 27 Fax: +49 (0)241-8082427 28 Email: [email protected] 29 30 Jens Malte Baron 31 Department of Dermatology and Allergology 32 RWTH Aachen University 33 Pauwelsstraße 30 34 52074 Aachen, Germany 35 Phone: +49 (0)241-8089162 36 Fax: +49 (0)241-8082413 37 Email: [email protected] 38 39 Running title: IL-31 – IL-1 signaling controls skin barrier 40 41

1 42 Supplementary Figure Legends 43 44 Supplementary Figure 1 45 (A - E) 3D models (24 h) were stimulated with or without rhIL-31 for 2, 8, 24 or 48 hours. 46 Gene expression was analyzed using Affymetrix exon arrays. Indicated are the fold changes 47 relative to the untreated control. 48 49 Supplementary Figure 2 50 FACS analysis of IL-1R1 and IL-1R2 surface expression on HaCaT-IL31RA cells in response 51 to rhIL-31 after 72 h. 52 53 Supplementary Table 1 54 3D organotypic skin equivalents were constructed with HaCaT-IL31RA cells and human 55 diploid fibroblasts. Twenty-four 24 hours later the skin equivalents were stimulated with 56 rhIL-31 for 2, 8, 24, 48 hours. Gene expression was analysed by Affymetrix exon arrays.

2 Figure S1

HaCaT-IL31RA 3D A 5 4 3 2 IL-31 (hours) 2 1 8 0 -1 24

fold change -2 -3 48 -4 -5 FLG KRT10 KRT4 KRT6A KRT7 KRT13 KRT16 KRT18 KRT23 KRTDAP IVL KRT1 KRT6B KRT6C KRT8 KRT15 KRT17 KRT19 KRT77

DSC1 DSG4 B DSG1 DSC2 C FLG CASP14 KLK7 0 0 IL-31 (hours) 2 2 IL-31 (hours) -4 -1 -8 8 8 -2 -12 24 24 fold change -16 48 fold change -3 -20 48 -4 D HaCaT-IL31RA 3D 14 12 10 2 IL-31 (hours) 8 8 6 4 24 fold change 2 48 0 -2 IL1A IL1R1 IL1RAP IRAK2 IL1F9 IL1B IL1R2 IL1RL2 IL1RN

HaCaT-IL31RA 3D E 14 12

10 2 IL-31 (hours) 8 6 8 4 24

fold change 2 0 48 -2 -4 S100A7 S100A8 S100A10 S100A14 DEFB103 S100A7A S100A9 S100A12 DEFB4A A/B Figure S2 A 100 IL1R1 IL1R2 +IL31 80 - IL31 Ab Control 60 Cells only maximum

f 40 o

% 20 0 100 101 102 103 104 101 102 103 104 FITC-A Supplementary Table 1 3D organotypic skin equivalents were constructed with HaCaT-IL31RA cells and HDFs and 24 hours later stimulated with rhIL-31 for 2,8,24,48 hours. Gene expression was analysed by Affymetrix exon arrays. Below mentioned are the fold changes with a fold change cutoff of ≥1.5 in one time point relative to the untreated control samples.

Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31

1-acylglycerol-3-phosphate O-acyltransferase 9 AGPAT9 1,1703792 1,0501187 1,6001107 1,6750937

1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional) ACCS 1,0218779 -1,1634649 -1,5385996 -1,4193476

10 kDa heat shock protein, mitochondrial-like LOC100132346 1,5344459 1,5193173 1,2131485 1,4550565

15 kDa selenoprotein 41167 1,0005276 1,2931415 1,6394274 1,6457914

190 kDa guanine nucleotide exchange factor RGNEF 1,0069957 -2,697763 -1,8495504 -1,6718744

2-oxoglutarate and iron-dependent oxygenase domain containing 1 OGFOD1 1,2714676 1,5251404 1,4201444 1,3949636

2'-5'-oligoadenylate synthetase 2, 69/71kDa OAS2 1,7088814 -1,0161432 1,2300854 2,7218952

2'-5'-oligoadenylate synthetase 3, 100kDa OAS3 1,252656 1,0409395 -1,1852047 2,0105035

2'-5'-oligoadenylate synthetase-like OASL 1,4588314 1,0954401 2,134089 2,2272432

2',5'-oligoadenylate synthetase 1, 40/46kDa OAS1 1,1610225 -1,713749 -1,5220916 1,2057772

24-dehydrocholesterol reductase DHCR24 1,1961695 -1,0862586 1,4868754 1,6338514

3-hydroxy-3-methylglutaryl-CoA reductase HMGCR -1,034345 1,0194466 2,5460756 2,4408684

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) HMGCS1 1,3087481 1,1915087 3,96342 3,8201897

3-hydroxybutyrate dehydrogenase, type 1 BDH1 -1,089647 -1,5875336 -1,5818377 -1,3744675

3-hydroxyisobutyryl-CoA hydrolase HIBCH 1,6743258 1,4448246 1,2284806 1,1320337

3-ketodihydrosphingosine reductase KDSR 1,4588169 1,7840765 1,5289015 1,6575063

3-phosphoinositide dependent protein kinase-1 | 3-phosphoinositide dependent protein kinase 1 pseudogene PDPK1|PDPK2 -1,0460736 -1,564175 -1,0751152 -1,227018

4-aminobutyrate aminotransferase ABAT 1,2802185 -1,7695861 -1,5089574 -1,8679624

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ATIC 1,5547858 1,8026408 1,4465581 1,6026634

5-methyltetrahydrofolate-homocysteine methyltransferase reductase MTRR 1,251685 1,4456298 1,4853783 1,52694

5'-3' exoribonuclease 2 XRN2 1,2847226 1,5395259 1,5071775 1,590007

5'-nucleotidase, ecto (CD73) NT5E -1,1949841 -1,1286303 1,0797625 1,6975168

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 PFKFB3 1,3392416 1,6792511 2,1090112 3,0825524

7-dehydrocholesterol reductase DHCR7 1,0408382 1,1951073 3,2973561 3,081931

A kinase (PRKA) anchor protein 12 AKAP12 -1,1584218 1,1329114 -1,0745127 1,9890292

A kinase (PRKA) anchor protein 6 AKAP6 1,2481706 2,615137 3,0445607 4,038722 abhydrolase domain containing 3 ABHD3 -1,0627153 -1,6622145 1,0084349 1,251925 abhydrolase domain containing 4 ABHD4 -1,1579467 -1,661685 1,0659362 -1,0745099 abhydrolase domain containing 6 ABHD6 -1,0956749 -1,8155041 -1,4482281 -1,5204631

ABI family, member 3 (NESH) binding protein ABI3BP -1,0130268 -1,1228611 1,2069461 2,88348 absent in melanoma 2 AIM2 1,4093603 1,5515267 1,4873315 1,1452473 ACAT2|LOC1001 acetyl-CoA acetyltransferase 2 | hypothetical LOC100129518 29518 -1,0802625 -1,2242978 1,8485744 1,7761981 acetyl-CoA carboxylase beta ACACB 1,365716 -1,5224383 -1,6449234 -1,5497 acid phosphatase, prostate ACPP -1,0418385 -1,3313135 1,9734756 1,4248037 ARPC1B|ARPC1 actin related protein 2/3 complex, subunit 1B, 41kDa | actin related protein 2/3 complex, subunit 1A, 41kDa A 1,2728896 1,5684999 2,6315663 2,8459442 actin related protein 2/3 complex, subunit 5-like ARPC5L 1,3539101 1,2018468 1,5564888 1,9625167 actin, alpha 1, skeletal muscle ACTA1 -1,2120992 1,5180613 1,2499925 -1,0689503 actinin, alpha 1 ACTN1 1,1049331 2,2775412 2,3352308 2,6439252 activated leukocyte cell adhesion molecule ALCAM 1,010737 -1,6771001 -1,3681664 -1,5286498 activating transcription factor 7 interacting protein ATF7IP 1,0608834 -1,5359447 -1,241394 -1,1924716 acyl-CoA dehydrogenase, short/branched chain ACADSB 1,1382318 -1,6233908 -1,5937335 -1,5000153 acyl-CoA oxidase 1, palmitoyl ACOX1 1,8784343 1,1403035 -1,0516444 1,0263252 acyl-CoA synthetase family member 2 ACSF2 -1,7965524 -2,0717294 -2,0585606 -2,0976906 acyl-CoA synthetase long-chain family member 1 ACSL1 -1,116393 -2,7733994 1,2581747 1,2506115 acyl-CoA synthetase long-chain family member 4 ACSL4 1,3425145 1,257281 1,8630784 2,8004045 acyl-CoA synthetase short-chain family member 1 ACSS1 1,0359318 -1,263571 -1,244773 -1,617685 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 acyl-CoA synthetase short-chain family member 2 ACSS2 1,0157013 1,082589 2,342158 2,2406104 acyloxyacyl hydrolase (neutrophil) AOAH -1,063567 -7,376544 -4,4870186 -5,5193872 acyloxyacyl hydrolase (neutrophil) FAM183B -1,0961859 1,068643 1,6916761 1,1398479 acylphosphatase 1, erythrocyte (common) type ACYP1 1,9481326 1,4093765 1,4339386 1,2550663

ADAM metallopeptidase domain 19 ADAM19 1,0996685 2,0131834 2,412553 2,4192085

ADAM metallopeptidase domain 23 ADAM23 1,2989424 -1,6372067 -1,3051476 -1,3433211

ADAM metallopeptidase domain 28 ADAM28 -1,098871 1,4926245 1,4904288 1,9118962

ADAM metallopeptidase domain 8 ADAM8 1,028931 1,5046127 2,4652517 2,2044525

ADAMTS-like 5 ADAMTSL5 -1,0229079 1,0542362 1,2999685 1,5898529 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 APPL2 1,1200534 1,2200099 1,4187849 1,6135998 adaptor-related protein complex 1, gamma 2 subunit AP1G2 -1,0196657 -1,3858433 -1,399641 -1,606451 adaptor-related protein complex 3, mu 2 subunit AP3M2 1,2798572 1,2852628 1,4778682 1,6156608 adenosine deaminase ADA 1,261847 1,899395 3,8035579 2,9860237 ADAD2|LOC6547 adenosine deaminase domain containing 2 | SFPQ 80 -1,5242841 -1,6134644 -1,5597558 -1,7529072 adenosine deaminase, tRNA-specific 2, TAD2 homolog (S. cerevisiae) ADAT2 1,3159888 1,5870636 1,209965 1,0462036 adenosylmethionine decarboxylase 1 AMD1 2,2158284 1,8958814 1,8503306 1,700837 adenylate cyclase 10 pseudogene LOC221442 -1,0253264 -1,3122569 -1,5225354 -1,1082908 adenylate kinase 4 AK4 -1,8191459 1,191912 -1,3063357 -1,3782597 adenylate kinase 4 AK4 -1,3109591 -1,052725 -1,0147041 -1,7936985 adenylate kinase domain containing 1 AKD1 1,0038935 -1,6228013 -1,2188954 -1,1469944 adenylosuccinate synthase ADSS -1,045853 -1,5468093 -1,244013 1,0053627 adhesion molecule with Ig-like domain 2 AMIGO2 -1,1023439 1,1892579 1,1916276 1,5212317 ADP-ribosylation factor GTPase activating protein 3 | protein kinase C and casein kinase substrate in neurons ARFGAP3|PACSI 2 N2 1,2717375 2,0019205 1,390038 1,7707673

ADP-ribosylation factor-like 4A ARL4A 1,1922942 1,4064867 1,7047942 1,6535792

ADP-ribosylation factor-like 4D ARL4D 1,8869755 2,3203127 2,4368122 2,407257

ADP-ribosylation-like factor 6 interacting protein 6 ARL6IP6 -1,1230371 -1,5438561 -1,2523447 1,0085415 adrenomedullin ADM -1,5127071 -1,6643355 -1,2769696 -1,1245284 agrin AGRN 1,0524797 -1,2028737 -1,2930773 -1,5608693

AHNAK nucleoprotein 2 AHNAK2 -1,1799897 -2,4766102 -1,224053 -1,1489472 akirin 2 AKIRIN2 1,2326152 1,1134892 1,3788966 1,5532491

AKT interacting protein AKTIP -1,259315 -1,7099423 -1,5124902 -1,555325 alanyl-tRNA synthetase AARS 1,410895 1,3392336 1,5880795 1,9137866 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide ADH7 1,1585033 -2,2831886 -2,8752804 -3,5087066 alcohol dehydrogenase, iron containing, 1 ADHFE1 1,1376675 -1,7575686 -1,344423 -1,591881 aldehyde dehydrogenase 1 family, member A1 ALDH1A1 2,1473837 -2,5394351 -4,771919 -5,3688426 aldehyde dehydrogenase 1 family, member A3 ALDH1A3 -1,019632 -1,0498316 -1,5802381 -1,5572308 aldehyde dehydrogenase 1 family, member L2 ALDH1L2 -1,4447558 -1,1733366 1,1596078 1,7184852 aldehyde dehydrogenase 2 family (mitochondrial) ALDH2 1,1374811 -1,4261898 -1,9853472 -2,0289185 aldehyde dehydrogenase 3 family, member B2 ALDH3B2 -1,4384348 -1,6703511 -1,0678849 -1,0819788 ALDH6A1|C14orf aldehyde dehydrogenase 6 family, member A1 | chromosome 14 open reading frame 45 45 1,0682054 -1,3936497 -1,6306269 -1,8105017 aldo-keto reductase family 1, member B10 (aldose reductase) AKR1B10 2,1851947 -1,5176018 -1,4890418 1,5452513 aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) AKR1C2 -1,0686955 -2,1260672 -1,4433421 -1,1508156 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) AKR1C3 1,1889277 -2,4338806 -1,2447422 1,2972559 aldolase C, fructose-bisphosphate ALDOC -3,0337694 -2,8974934 -1,1169285 -1,1442602 alkaline ceramidase 3 ACER3 1,2942934 2,4536777 2,428444 2,2936954 alkaline phosphatase, placental ALPP -1,1449983 -1,0889456 -1,775228 -1,2206411 alkaline phosphatase, placental-like 2 ALPPL2 -1,43627 -1,3007687 -1,5393559 -1,6133171 allograft inflammatory factor 1-like AIF1L -1,1119545 -1,0274246 1,6125144 1,1547092 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 alpha-kinase 1 ALPK1 1,356065 1,1585156 1,1452597 1,8207809 AMACR|C1QTNF alpha-methylacyl-CoA racemase | C1q and tumor necrosis factor related protein 3 3 -1,0028826 -1,4765118 -1,2098442 -1,5234526

ALS2 C-terminal like ALS2CL -1,1835454 -2,1361961 -1,715037 -1,3819197 amiloride binding protein 1 (amine oxidase (copper-containing)) ABP1 1,0002532 -1,4042172 -1,6364315 -1,1837605 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 | eukaryotic translation initiation factor 2-alpha kinase 1 AIMP2|EIF2AK1 1,3474836 1,6916504 1,215249 1,3604242 aminoadipate-semialdehyde synthase AASS 1,6225932 1,707799 1,5925715 1,3650147 aminolevulinate, delta-, synthase 1 ALAS1 1,3023032 1,4337424 1,3150615 1,7763356 aminopeptidase puromycin sensitive NPEPPS -1,2390797 1,4217751 1,5829072 1,5109622 amphiregulin AREG 1,5746146 2,7137685 3,133577 2,8573864 amphiregulin AREG 1,2756929 1,9082497 2,4073303 2,5504265 AMY1A|AMY1B| amylase, alpha 1A (salivary) | amylase, alpha 1B (salivary) | amylase, alpha 1C (salivary) | amylase, alpha 2A AMY1C|AMY2A| (pancreatic) | amylase, alpha 2B (pancreatic) AMY2B 1,1319768 -1,1758349 -1,540495 -1,7147275 AMY1A|AMY1B| amylase, alpha 1A (salivary) | amylase, alpha 1B (salivary) | amylase, alpha 1C (salivary) | amylase, alpha 2A AMY1C|AMY2A| (pancreatic) | amylase, alpha 2B (pancreatic) AMY2B 1,1408342 -1,1673788 -1,5433546 -1,7199814 AMY1A|AMY1B| amylase, alpha 1A (salivary) | amylase, alpha 1B (salivary) | amylase, alpha 1C (salivary) | amylase, alpha 2A AMY1C|AMY2A| (pancreatic) | amylase, alpha 2B (pancreatic) AMY2B 1,1448234 -1,1702375 -1,5472598 -1,7153528 AMY2A|AMY1A| amylase, alpha 2A (pancreatic) | amylase, alpha 1A (salivary) | amylase, alpha 1B (salivary) | amylase, alpha AMY1B|AMY1C| 1C (salivary) | amylase, alpha 2B (pancreatic) AMY2B 1,1948367 -1,2255002 -1,6047035 -2,0381556 amylase, alpha 2B (pancreatic) | RNA-binding region (RNP1, RRM) containing 3 AMY2B|RNPC3 1,27662 -1,2851452 -1,4757985 -1,7779509 amyotrophic lateral sclerosis 2 (juvenile) ALS2 -1,0374998 -1,5755621 -1,0804397 1,0415589 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12 ALS2CR12 1,0038526 -1,9283772 -1,3709549 -1,7519168 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8 ALS2CR8 1,1298276 -1,4745226 -1,5292916 -1,3592843 androgen-induced 1 AIG1 1,0502402 1,3929751 1,5215871 1,232669 angel homolog 1 (Drosophila) ANGEL1 1,4955702 1,2436923 1,0085199 -1,0010046 angiogenin, ribonuclease, RNase A family, 5 | ribonuclease, RNase A family, 4 ANG|RNASE4 -1,9869483 -1,6374979 -1,5108428 -1,8436905 angiopoietin-like 4 ANGPTL4 -1,2168989 2,2339058 2,1230688 1,4731756 angiotensin II receptor-associated protein AGTRAP 1,0328357 1,6817739 2,200569 2,2641587 anillin, actin binding protein ANLN -1,2658371 -2,509703 -1,3225167 1,3227148 ankyrin 3, node of Ranvier (ankyrin G) ANK3 1,449169 -1,5600374 -1,6219385 -1,7620997 ankyrin repeat and GTPase domain Arf GTPase activating protein 11 | ArfGAP with GTPase domain, ankyrin AGAP11|AGAP5| repeat and PH domain 5 | family with sequence similarity 25, member A | ArfGAP with GTPase domain, FAM25A|AGAP4| ankyrin repeat and PH domain 4 | family with sequence similarity 25, member B | family with sequence FAM25B|FAM25 similarity 25, member C | family with sequence similarity 25, member G C|FAM25G -1,112215 -1,5194694 -1,4679807 -1,5537605 ankyrin repeat and MYND domain containing 2 ANKMY2 -1,0984422 -1,647509 -1,381117 -1,4962862 ankyrin repeat and SOCS box-containing 9 ASB9 1,1607374 -2,1516857 -1,6032202 -1,9688108 ankyrin repeat domain 16 ANKRD16 -1,0660099 -1,531125 -1,1304607 -1,1122599 ankyrin repeat domain 18A ANKRD18A 1,5265086 1,0379426 1,0337934 1,1948367 ankyrin repeat domain 18B ANKRD18B 1,2064421 -1,2888267 -1,5539684 -1,1059046

ANKRD20A3|AN KRD20A2|ANKR ankyrin repeat domain 20 family, member A3 | ankyrin repeat domain 20 family, member A2 | ankyrin repeat D20A1|ANKRD2 domain 20 family, member A1 | ankyrin repeat domain 20 family, member A4 | ankyrin repeat domain 20B 0A4|ANKRD20B 1,1009403 -1,5172045 -1,1536651 -1,2572069 ankyrin repeat domain 20 family, member A3 pseudogene C21orf81 -1,1610897 -1,5011709 -1,3754232 -1,3816658 ANKRD20B|LOC ankyrin repeat domain 20B | hypothetical LOC644249 644249 1,1742134 -1,5921278 -1,3915017 -1,1199931 ANKRD20B|LOC ankyrin repeat domain 20B | hypothetical LOC644249 644249 1,2259551 -1,5945165 -1,4134169 1,0270212 ANKRD20B|LOC ankyrin repeat domain 20B | hypothetical LOC644249 644249 1,1470178 -2,1486228 -1,6039648 -1,2308325 ankyrin repeat domain 22 ANKRD22 2,2416756 4,498005 4,9584274 5,7681212 ANKRD23|ANKR ankyrin repeat domain 23 | ankyrin repeat domain 39 D39 -1,0278246 -1,2026837 -1,5083197 -1,3816828 ankyrin repeat domain 29 ANKRD29 -1,0227219 1,2840527 1,4993163 2,439032 ankyrin repeat domain 36 ANKRD36 -1,04909 -1,7716508 -1,292008 -1,2844967 ANKRD36B|LOC ankyrin repeat domain 36B | ankyrin repeat domain 36 | ankyrin repeat domain-containing protein 36C | 400986|LOC1005 ankyrin repeat domain-containing protein 36C-like 10023 -1,2764927 -2,0961492 -1,8479812 -1,5992514 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 ANKRD36B|LOC ankyrin repeat domain 36B | ankyrin repeat domain 36 | ankyrin repeat domain-containing protein 36C | 400986|LOC1005 ankyrin repeat domain-containing protein 36C-like 10023 -1,1814485 -2,4550242 -1,7024703 -1,5173129 ANKRD36B|LOC ankyrin repeat domain 36B | ankyrin repeat domain 36 | ankyrin repeat domain-containing protein 36C | 400986|LOC4009 ankyrin repeat domain-containing protein 36C-like 87 -1,2334328 -2,0349562 -1,476953 -1,5362626 ANKRD36B|LOC ankyrin repeat domain 36B | ankyrin repeat domain 36 | ankyrin repeat domain-containing protein 36C-like 100510023 -1,2170795 -2,46302 -1,7601119 -1,5732194 ANKRD36B|LOC ankyrin repeat domain 36B | ankyrin repeat domain-containing protein 36A-like 100510355 -1,2548349 -1,8916101 -1,5643772 -1,2942643 ankyrin repeat domain-containing protein 36C LOC400986 -1,3953398 -2,3318071 -1,742031 -1,8066783 ankyrin repeat, family A (RFXANK-like), 2 ANKRA2 1,0053442 -1,5617728 -1,0819176 -1,0585889 annexin A1 ANXA1 -1,0507683 1,4148027 1,9830152 1,9869056 annexin A10 ANXA10 1,3064419 -1,046326 1,8699206 1,9825675 annexin A2 ANXA2 1,0171283 1,6838452 1,6333795 1,6321695 annexin A2 pseudogene 1 ANXA2P1 -1,0843972 1,3817855 1,4761293 1,8929454 annexin A2 pseudogene 2 ANXA2P2 -1,0790068 1,5461878 1,6241149 1,6190649 annexin A2 pseudogene 3 ANXA2P3 -1,0301067 1,7007116 1,3268732 1,1962736 annexin A3 ANXA3 -1,3129013 3,4718678 6,5298285 6,1182423 annexin A9 | family with sequence similarity 63, member A ANXA9|FAM63A -1,2542577 -1,4069852 -2,1050618 -1,9137886 anoctamin 1, calcium activated chloride channel ANO1 1,1447935 -1,4116918 -1,4073461 -1,5601879 anoctamin 9 ANO9 -1,090724 -1,7964526 -2,0039768 -1,9906695 anterior gradient homolog 2 (Xenopus laevis) AGR2 1,1479983 -3,0400507 -1,6987605 -1,6697787 anthrax toxin receptor 2 ANTXR2 -1,1615453 -1,0016917 1,458922 1,8316637 antigen identified by monoclonal antibody Ki-67 MKI67 -1,0704122 -1,5999737 -1,0280228 1,288972 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A APOBEC3A -1,272951 -2,549625 -2,4581966 -3,0162923 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | apolipoprotein B mRNA editing enzyme, APOBEC3B|APO catalytic polypeptide-like 3A BEC3A -1,1464361 -2,164676 -2,1446261 -2,221798 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F APOBEC3F -1,0349107 -1,2114364 -1,4117794 -1,5604742 apolipoprotein L, 1 APOL1 1,7370657 2,7139432 1,8967081 2,2296224 apolipoprotein L, 2 APOL2 1,4958317 1,5539068 1,1213665 1,3765206 apolipoprotein L, 3 APOL3 1,2534094 1,6747631 1,0389754 -1,1204418 apolipoprotein L, 4 APOL4 1,4580616 4,204825 5,8354588 5,5588326 apolipoprotein L, 6 APOL6 1,8976806 1,3779235 -1,0078428 1,4399904 apoptosis enhancing nuclease AEN 1,377225 1,8429052 1,5368496 1,613842 apoptosis-inducing factor, mitochondrion-associated, 1 AIFM1 1,6289015 1,1574156 1,3366759 1,3291425 apoptosis, caspase activation inhibitor AVEN 1,1193058 1,5879257 1,5442761 2,02395 apoptotic peptidase activating factor 1 APAF1 -1,0317965 -1,662969 -1,2856053 -1,3717681 aquaporin 7 AQP7 -1,189441 1,0410072 -1,0793436 -1,5078431 arachidonate 12-lipoxygenase pseudogene 2 ALOX12P2 1,8143331 1,2641989 1,2208651 1,1863577 arachidonate 12-lipoxygenase, 12R type ALOX12B 1,0212097 -1,0266116 1,6006624 1,830313 archaelysin family metallopeptidase 2 pseudogene 1 AMZ2P1 -1,0596834 -1,655068 -1,4223161 -1,003261

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 ARAP3 1,1391312 -1,2999259 -1,4603621 -1,6427882

ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 ASAP3 -1,0272717 -1,5479482 -1,4111618 -1,4668574 arginine vasopressin-induced 1 AVPI1 -1,4142225 -1,6508739 -1,0155965 1,0761454 armadillo repeat containing, X-linked 6 ARMCX6 1,0110633 -1,6403288 -1,2006712 -1,0133159

ARP3 actin-related protein 3 homolog (yeast) ACTR3 1,059348 1,3121706 1,6084678 1,5587355

ARP3 actin-related protein 3 homolog C (yeast) ACTR3C 1,6264349 1,2480395 1,5110346 1,4562844 arrestin domain containing 4 ARRDC4 1,24655 1,0794884 1,3790005 1,5357316 arrestin, beta 1 ARRB1 1,0370061 -1,2391894 -1,3974246 -1,522303 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 aryl hydrocarbon receptor AHR 1,2957127 1,4418696 1,4523846 1,920789 aryl hydrocarbon receptor nuclear translocator ARNT -1,1846415 -1,6234536 -1,3265251 -1,3751063 aryl hydrocarbon receptor nuclear translocator-like 2 ARNTL2 1,9364278 4,1339545 3,9929094 4,1863666 arylsulfatase family, member I ARSI -1,0542978 -3,2151349 -2,453826 -2,1544867 arylsulfatase family, member K ARSK 1,2419366 -1,5802824 1,1177406 -1,0416952

ASF1 anti-silencing function 1 homolog B (S. cerevisiae) ASF1B -1,0485278 1,001323 1,5943232 1,5757303 asp (abnormal spindle) homolog, microcephaly associated (Drosophila) ASPM 1,1318481 -2,125234 -1,0589608 1,4349798 asparagine synthetase (glutamine-hydrolyzing) ASNS 1,1691855 1,3572189 1,6552022 1,723484 aspartylglucosaminidase AGA 1,0204104 -1,5088876 -1,4514483 -1,1700763

AT rich interactive domain 5B (MRF1-like) ARID5B 1,2282045 1,7416942 1,6248118 1,7306582 atlastin GTPase 1 ATL1 1,0210383 -1,9226106 -1,3276207 -1,3116248 atlastin GTPase 2 ATL2 -1,007473 -1,7403022 -1,1320853 -1,1516778 atlastin GTPase 3 ATL3 1,036695 1,0929629 1,4054514 1,5657495

ATP citrate lyase ACLY 1,0519831 1,1341811 2,6537359 2,3292675

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) ATP5G1 1,4323244 1,5568109 -1,0538101 -1,2024015

ATP-binding cassette, sub-family A (ABC1), member 1 ABCA1 1,1694975 1,3600065 3,6984503 5,0057063

ATP-binding cassette, sub-family A (ABC1), member 10 ABCA10 -1,1640218 -1,8293302 -1,7116619 -1,4689796

ATP-binding cassette, sub-family A (ABC1), member 12 ABCA12 -1,2203487 -2,8511722 -2,731662 -2,0148768

ATP-binding cassette, sub-family A (ABC1), member 13 ABCA13 1,3696673 1,7560136 2,2981286 2,3574123

ATP-binding cassette, sub-family A (ABC1), member 2 ABCA2 -1,0311723 -1,3144339 -1,4337709 -1,58687

ATP-binding cassette, sub-family A (ABC1), member 5 ABCA5 1,1046242 -1,8864754 -1,908779 -1,6958479 ATP-binding cassette, sub-family B (MDR/TAP), member 6 | ATG9 autophagy related 9 homolog A (S. cerevisiae) ABCB6|ATG9A -1,2509593 -1,349699 -1,5584 -1,4030597

ATP-binding cassette, sub-family C (CFTR/MRP), member 5 ABCC5 1,2577821 -3,310436 -1,5289682 -1,6234043

ATP-binding cassette, sub-family E (OABP), member 1 ABCE1 1,8031932 1,8430648 1,3949913 1,6206615

ATP-binding cassette, sub-family G (WHITE), member 1 ABCG1 -1,1047848 -1,3056028 -1,4284642 -1,612734

ATPase type 13A3 ATP13A3 1,2581913 1,2834765 1,4614645 1,6330178

ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 ATP8A1 1,0318087 -1,8793012 -1,8382416 -1,8180808

ATPase, Ca++ transporting, plasma membrane 1 ATP2B1 1,1183474 -1,0013176 1,3552917 1,7127185

ATPase, Ca++ transporting, plasma membrane 4 ATP2B4 -1,2241032 -1,5523684 -1,1016352 -1,3736764

ATPase, class V, type 10B ATP10B -1,6613011 1,5314819 1,9840641 1,3162377

ATPase, class VI, type 11A ATP11A 1,104215 -1,6209449 -1,2394443 -1,2041717

ATPase, class VI, type 11C ATP11C 1,0874664 1,1313548 1,375927 1,702059

ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 ATP6V0D2 1,3043842 1,8513577 3,4108112 3,1945093

ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 ATP6V1B1 1,2901735 -1,0640776 -1,6579951 -2,161205

ATPase, Na+/K+ transporting, beta 1 polypeptide ATP1B1 -1,262814 -2,7110028 -1,798192 -2,3993964

ATPase, Na+/K+ transporting, beta 2 polypeptide ATP1B2 -1,5040817 1,2607826 1,1242326 -1,3927721

ATPase, Na+/K+ transporting, beta 3 polypeptide ATP1B3 1,1375216 -2,5756676 -1,9155991 -1,9735721 aurora kinase A AURKA 1,0849253 -1,7276679 1,1139997 1,4808508 autism susceptibility candidate 2 AUTS2 -1,2665447 -1,5087395 -1,3723744 -1,3742785

B-cell CLL/lymphoma 11A (zinc finger protein) BCL11A -1,6310893 -2,6886842 -1,5730858 -1,9087714

B-cell CLL/lymphoma 3 BCL3 1,9141978 2,1110294 1,6836282 1,855313

B-cell CLL/lymphoma 9-like BCL9L -1,2259746 -1,700972 -1,4594555 -1,5768843

B-cell receptor-associated protein 29 BCAP29 -1,0673944 1,0298326 1,5511426 1,4991504

B-cell translocation gene 1, anti-proliferative BTG1 -1,5053514 -1,9353273 -1,3300451 -1,232449 baculoviral IAP repeat-containing 3 BIRC3 1,584476 1,0679138 -1,4179785 -1,013536

BAH domain and coiled-coil containing 1 BAHCC1 -1,0736805 1,5208435 1,1768613 1,0930365

BAI1-associated protein 2 BAIAP2 -1,1880984 -1,5405943 1,00914 1,0349188

Bardet-Biedl syndrome 12 BBS12 -1,0735471 -1,5394129 1,222069 1,2167851 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31

Bardet-Biedl syndrome 2 BBS2 -1,05061 -1,6492841 -1,2085134 -1,1959742

Bardet-Biedl syndrome 9 BBS9 1,2868938 -1,8204691 -1,5072083 -1,318538 basal cell adhesion molecule (Lutheran blood group) BCAM -1,0291603 -1,0339218 1,0187002 -1,5598642 basic helix-loop-helix family, member a9 BHLHA9 -1,1734383 1,8307486 1,0445099 -1,4507903 basic helix-loop-helix family, member e41 BHLHE41 -1,0666445 -2,6184921 -2,6213436 -2,684826 basic leucine zipper and W2 domains 1 BZW1 1,1424885 1,6477498 1,6664833 2,1441016 basic leucine zipper transcription factor, ATF-like 3 BATF3 -1,2233739 1,3630549 1,1541322 1,7717047 basic, immunoglobulin-like variable motif containing BIVM 1,0918552 -1,1856012 1,1712475 1,5409869 basonuclin 1 BNC1 1,2535855 1,1913472 1,2072662 1,5580575

Bcl2 modifying factor BMF -1,0043826 -1,5819606 -1,2343692 -1,3490933

BCL2-antagonist/killer 1 BAK1 1,947895 1,3676655 1,3966097 1,1555915

BCL2-associated athanogene BAG1 -1,0168333 -1,5726382 -1,3208358 -1,6187332

BCL2-associated athanogene 3 BAG3 1,501282 1,4219725 1,2426034 1,3086131

BCL2-like 1 BCL2L1 1,0129046 1,5505152 1,121619 1,4044808

BCL2-like 11 (apoptosis facilitator) BCL2L11 2,1240993 1,2139097 1,4697828 1,3827147

BCL2/adenovirus E1B 19kD interacting protein like BNIPL -1,402897 -2,7316477 -2,315605 -3,260483

BCL2/adenovirus E1B 19kDa interacting protein 3 BNIP3 -3,291524 -1,8887495 1,4578447 1,6155823 beta-carotene oxygenase 2 BCO2 1,1666017 -1,35888 -1,3681679 -1,5414184 beta-site APP-cleaving enzyme 2 BACE2 1,0808858 1,6857586 2,3273897 2,107258 betaine--homocysteine S-methyltransferase BHMT -1,0947547 1,1157577 1,2253852 -1,5027609 block of proliferation 1 BOP1 1,0057406 1,6459998 1,0894186 1,1106523

BMP2 inducible kinase BMS1P1|BMS1PBMP2K -1,0187427 -1,0378 1,3198208 1,538892 BMS1 pseudogene 1 | BMS1 pseudogene 5 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 10 5|AGAP10|AGAP | ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 BMS1P1|BMS1P9 -1,0409904 -1,2431687 -1,4416085 -1,5403758 BMS1 pseudogene 1 | BMS1 pseudogene 5 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 10 5|AGAP10|AGAP | ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 9 -1,070079 -1,2851872 -1,4788151 -1,5524032 bolA homolog 3 (E. coli) BOLA3 1,3838761 1,5761673 1,2542435 1,0750058 bone morphogenetic protein 1 BMP1 -1,0468345 -1,8063195 -1,3508732 -1,3131087 bone morphogenetic protein 3 BMP3 -1,2270246 -3,130548 -2,6638181 -4,436244 bone morphogenetic protein 7 BMP7 -1,4606899 -3,0246983 -1,693511 -2,1389558 bone morphogenetic protein receptor, type IA BMPR1A 1,0449829 -1,5476745 -1,1610693 -1,1838728 brain protein I3 BRI3 -1,1336955 -1,5480522 -1,3242077 1,0236428 branched chain keto acid dehydrogenase E1, beta polypeptide BCKDHB 1,1161355 -1,5801702 -1,55313 -1,6177651 breakpoint cluster region BCR 1,6026654 2,1560946 2,0154243 2,3174155 breakpoint cluster region | breakpoint cluster region pseudogene BCR|FLJ42953 1,2802163 1,8797808 1,4823709 1,3210021 breakpoint cluster region | breakpoint cluster region pseudogene BCR|FLJ42953 1,2548593 1,7112931 1,498238 1,30032 breast cancer 1, early onset BRCA1 1,034131 -1,4738346 1,146069 1,5563941 breast cancer 2, early onset BRCA2 1,2100898 -1,2390342 1,1458558 1,5064329 breast cancer anti-estrogen resistance 1 BCAR1 1,3352863 1,5452845 1,2959929 1,3497173 breast carcinoma amplified sequence 1 BCAS1 -1,1931682 -1,615357 -1,6284746 -1,6353809 bromodomain and WD repeat domain containing 1 BRWD1 -1,0606471 -1,5583501 -1,2154144 -1,0352179

BRX1, biogenesis of ribosomes, homolog (S. cerevisiae) | RAD1 homolog (S. pombe) BRIX1|RAD1 1,2103121 1,4416066 1,3629842 1,5098494

BTB (POZ) domain containing 11 BTBD11 -1,0401591 1,5636204 1,9913038 2,0137124

BTG family, member 2 BTG2 -1,066646 -1,801714 -1,632926 -1,6807182 budding uninhibited by benzimidazoles 1 homolog (yeast) BUB1 -1,0603092 -1,5037411 1,2459584 1,3298869 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 BBOX1 -1,1614186 -4,0692315 -2,108505 -3,640996 butyrophilin, subfamily 3, member A1 BTN3A1 1,8618885 -1,1142291 -1,6354549 -1,0548444 butyrophilin, subfamily 3, member A2 BTN3A2 1,4319627 -1,2791606 -1,6741664 -1,3294957 butyrophilin, subfamily 3, member A3 BTN3A3 1,415544 -1,1724153 -1,824827 -1,1605452 bystin-like BYSL 1,2810683 1,6784931 1,3564044 1,4081222 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 c-fos induced growth factor (vascular endothelial growth factor D) FIGF 1,2713141 -1,7366472 -1,0252504 -1,0496932

C-reactive protein, pentraxin-related CRP -1,1275587 1,3916916 1,4376701 2,387979

C-type lectin domain family 2, member B CLEC2B -1,0161949 -2,2066782 -1,9030862 -1,6344445

C-type lectin domain family 7, member A CLEC7A 1,0999496 -1,6428018 -1,1513689 1,121798

C1q and tumor necrosis factor related protein 6 C1QTNF6 1,0397215 1,6215943 1,7186557 1,5667709 cadherin 3, type 1, P-cadherin (placental) CDH3 1,1484568 2,6589158 2,3375504 2,3548448 cadherin 8, type 2 CDH8 1,4880273 -1,4010476 -1,5189121 -1,9664189 cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila) CELSR2 -1,1244838 -1,7389895 -1,7621073 -1,9415548 calbindin 1, 28kDa CALB1 -3,169969 -3,467715 -1,5381033 -1,4283367 calbindin 2 CALB2 1,0302116 1,5725608 1,9390025 2,4216895 calcineurin B homologous protein 2 CHP2 -1,1696323 -1,105504 -1,4547681 -1,629538 calcitonin receptor-like CALCRL 1,0338597 1,0031445 1,2226726 1,6161885 calcium and integrin binding 1 (calmyrin) | chromosome 15 open reading frame 58 CIB1|C15orf58 -1,1472367 1,2182789 1,616165 1,7044104 calcium binding protein 39 CAB39 -1,0311487 1,3700327 1,3808331 1,5631073 calcium channel, voltage-dependent, alpha 2/delta subunit 2 CACNA2D2 -2,1469758 -1,2605006 1,1489651 -1,02483 calcium channel, voltage-dependent, beta 3 subunit CACNB3 -1,1723812 -1,583184 -1,6046557 -1,3151722 calcium channel, voltage-dependent, gamma subunit 4 CACNG4 -1,5186124 -1,4247924 -2,0640833 -2,5903053 calcium/calmodulin-dependent protein kinase II alpha CAMK2A 1,2358665 -2,2652097 -3,821617 -2,5269024 calcium/calmodulin-dependent protein kinase II gamma CAMK2G -1,2134131 -1,8066348 -1,7741412 -1,7277068 calcium/calmodulin-dependent protein kinase II inhibitor 1 CAMK2N1 -1,3214637 -1,174033 -1,4067312 -1,7249829 calmin (calponin-like, transmembrane) CLMN -1,4487486 1,7143484 2,44589 3,0896027 calpain 13 CAPN13 -1,090825 1,080471 -1,1330152 -1,5057684 calpain, small subunit 2 CAPNS2 -1,0449829 -3,376366 -2,581673 -3,1808653 calponin 2 CNN2 1,0245866 1,5000311 1,6693213 1,6977289 calsyntenin 1 CLSTN1 -1,0690135 -1,6014625 -1,3049996 -1,3072678 calumenin CALU 1,0666404 -1,0330433 1,2242804 1,5178716 cancer susceptibility candidate 5 CASC5 -1,0046439 -1,8058921 -1,1327897 1,2281282

CAP-GLY domain containing linker protein 1 CLIP1 1,2388659 2,3810902 2,4003196 2,0412033

CAP-GLY domain containing linker protein 2 CLIP2 -1,0525253 -1,6947126 -1,290816 -1,1955806

CAP-GLY domain containing linker protein family, member 4 CLIP4 1,2044667 -1,6332597 -1,0723677 -1,1789551 caprin family member 2 CAPRIN2 1,0560081 -1,0774139 1,227308 1,6860561 carbohydrate (chondroitin 4) sulfotransferase 11 CHST11 1,1343687 1,9336476 1,7210101 2,1158214 carbonic anhydrase II CA2 1,2958481 -1,08097 -1,3431523 -1,763276 carbonic anhydrase IX CA9 -2,6938329 -1,1257768 -1,2030094 -1,274243 carbonic anhydrase XI CA11 -1,1354065 1,0877395 -1,2126594 -1,6101577 carbonic anhydrase XII CA12 -1,6725725 -1,8530443 -1,1385373 1,1986479 carbonic anhydrase XIII CA13 1,8163096 1,1333358 -1,148713 -1,2565659 carboxyl ester lipase (bile salt-stimulated lipase) CEL -1,7656536 -1,4237516 -1,1302074 -1,0006665 carboxylesterase 1 CES1 -1,5554515 1,3644518 -1,0421033 -1,4764836 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) CEACAM1 1,9208194 2,286399 2,8631077 3,6522255 carcinoembryonic antigen-related cell adhesion molecule 5 CEACAM5 -1,3310672 2,6898496 -1,4126196 -1,1043965 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) CEACAM6 -1,0004143 2,8353019 1,0365151 1,4329039 carcinoembryonic antigen-related cell adhesion molecule 7 CEACAM7 -1,5333391 -1,7429374 -3,0386906 -3,462773 carnitine O-acetyltransferase CRAT 1,2064484 -1,6855463 1,242877 1,2490319 carnitine O-octanoyltransferase CROT -1,0458323 -3,2861302 -2,963094 -2,8715308 cartilage intermediate layer protein 2 CILP2 -1,2918577 1,5929142 -1,0238594 -1,1696266

Cas-Br-M (murine) ecotropic retroviral transforming sequence b CBLB -1,0436796 -1,6930208 -1,2403852 -1,2684965 caspase 14, apoptosis-related cysteine peptidase CASP14 -2,2980905 -2,6740146 -2,748119 -3,7865653 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 caspase 4, apoptosis-related cysteine peptidase CASP4 1,2958969 1,5026392 1,344723 2,135435 caspase 5, apoptosis-related cysteine peptidase CASP5 1,1794493 1,624555 1,2365333 1,1832441 caspase 8 associated protein 2 CASP8AP2 1,0235653 -1,5026064 -1,04007 1,0449992 caspase recruitment domain family, member 11 CARD11 -1,2219902 -1,1470771 1,1318983 1,7256163 caspase recruitment domain family, member 16 CARD16 1,3547319 -1,0678482 -1,0935508 -1,5662832 caspase recruitment domain family, member 6 CARD6 1,1335231 1,1388507 1,548529 1,7505212 castor zinc finger 1 CASZ1 -1,0855329 -1,8542384 -1,2999401 -1,36031 castor zinc finger 1 CASZ1 -1,1332523 -1,9192286 -1,438557 -1,3432531 castor zinc finger 1 CASZ1 -1,1679168 -2,1788309 -1,495207 -1,5459051 cathepsin B CTSB 1,2473396 1,8499746 1,8664207 2,1089594 cathepsin H CTSH -1,0026437 -1,7383424 -2,064234 -2,1583233 cathepsin L1 CTSL1 1,0087066 2,668082 3,721063 6,0477614 cathepsin S CTSS 1,1117078 -1,1398664 -2,2074528 -1,6023111 cation channel, sperm associated 2 CATSPER2 1,0487908 -1,5439357 -1,4260455 -1,3136287 cation channel, sperm-associated, beta CATSPERB 1,0178195 1,0751592 1,6842109 1,9143832 caveolin 1, caveolae protein, 22kDa CAV1 -1,0528499 -1,2188967 -1,5652176 -1,6260086

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 CITED4 1,4936743 2,3917832 1,6764606 1,9450804

CCAAT/enhancer binding protein (C/EBP), alpha CEBPA -1,599133 -1,2841936 -1,6168313 -1,4480821

CCAAT/enhancer binding protein (C/EBP), beta CEBPB 1,6564767 1,2186784 1,4521245 1,8479104

CCAAT/enhancer binding protein (C/EBP), delta CEBPD 1,4371936 1,6852683 1,5048828 1,880478

CCR4 carbon catabolite repression 4-like (S. cerevisiae) CCRN4L 1,3642128 1,5716779 1,3921199 1,1915233

CD225 family protein FLJ76511 LOC402778 -1,0216885 -1,9290949 -1,5274973 -1,6213901

CD300a molecule CD300A -1,0769141 -1,0939926 -1,6753073 -1,6355398

CDC-like kinase 1 | peptidylprolyl isomerase (cyclophilin)-like 3 CLK1|PPIL3 1,1653876 -1,5274851 -1,1732246 -1,0538359

CDC-like kinase 3 | hypothetical protein LOC646748 CLK3|FLJ42022 -1,0227466 -1,6871176 -1,2628517 -1,3290238

CDC-like kinase 4 CLK4 1,0683488 -1,521012 -1,0840224 -1,1663071

CDC-like kinase 4 CLK4 -1,1172833 -1,6638696 -1,4179945 -1,1902126

CDC28 protein kinase regulatory subunit 2 CKS2 -1,020719 -1,1710814 1,2524052 2,3390715

CDC42 binding protein kinase gamma (DMPK-like) CDC42BPG -1,1072626 -1,876451 -1,386889 -1,5386362

CDK5 regulatory subunit associated protein 2 CDK5RAP2 1,0137621 -1,5656993 -1,266721 -1,2437358

CDK5 regulatory subunit associated protein 3 CDK5RAP3 1,0379127 -1,5080371 -1,5714655 -1,4998552

CDKN1A interacting zinc finger protein 1 CIZ1 1,0053129 -1,6045364 -1,4940559 -1,2410946

CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 CDS1 -1,1141518 -1,578671 -1,1585883 -1,1104424 cell cycle progression 1 CCPG1 1,0965389 -1,7338008 -1,2868619 -1,1880481 cell division cycle 25 homolog B (S. pombe) CDC25B 1,0378641 1,121576 1,3193191 1,6507543 cell division cycle 25 homolog C (S. pombe) CDC25C 1,0188043 -1,9292613 -1,0273223 1,1695203 cell division cycle 6 homolog (S. cerevisiae) CDC6 -1,2283388 -1,1571001 1,2551969 1,5828905 cell division cycle 7 homolog (S. cerevisiae) CDC7 2,0222712 2,0782797 1,3887063 1,814281 cell division cycle associated 2 CDCA2 -1,0576254 -1,6143306 1,221722 1,2135367 cell division cycle associated 8 CDCA8 -1,0430992 -1,5117105 -1,1338401 1,0993305 cellular repressor of E1A-stimulated genes 1 CREG1 1,0583842 -1,4311612 -1,5529996 -1,5031866 cellular retinoic acid binding protein 2 CRABP2 -1,2039381 -2,2634232 -2,0329146 -2,5565927 centromere protein E, 312kDa CENPE 1,2266357 -1,8272871 -1,0418302 1,5333178 centromere protein F, 350/400kDa (mitosin) CENPF 1,0605447 -1,913225 -1,1066294 1,3369856 centromere protein I CENPI 1,0662978 -1,8052475 1,1859641 1,4809242 centromere protein N | chromosome 16 open reading frame 61 CENPN|C16orf61 -1,0370767 -1,2275982 1,4306868 1,7031626 centromere protein T CENPT 1,6289102 1,912926 3,057912 2,2981148 centromere protein W CENPW 1,2414523 -1,708874 1,2190974 1,3867565 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 centrosomal protein 152kDa CEP152 1,0854586 -1,5169634 -1,1740675 1,1691988 centrosomal protein 55kDa CEP55 1,0456367 -1,4786 -1,0033554 1,6493473 centrosomal protein 57kDa CEP57 -1,0921779 -1,519926 -1,0251732 1,0497373 centrosomal protein 57kDa pseudogene LOC646870 -1,1606504 1,5439434 -1,1488675 -1,2011193 centrosomal protein 68kDa CEP68 -1,0890007 -1,4258245 -1,4844173 -1,5141642 centrosomal protein 76kDa CEP76 -1,1450183 -1,5431362 1,0822273 1,0411662 ceramide kinase CERK -1,0454776 -1,6557854 -1,0869927 -1,2561561 cerebellar degeneration-related protein 1, 34kDa | YTH domain containing 2 CDR1|YTHDC2 -1,1656134 -1,3269833 -1,0087812 1,5368111 cerebellar degeneration-related protein 2-like CDR2L -1,2838011 -1,3421063 -1,3575907 -1,7092807 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) CLN8 -1,0754912 -1,6327696 -1,1651858 -1,3674712

ChaC, cation transport regulator homolog 1 (E. coli) CHAC1 -1,108828 1,6215698 -1,0402316 1,5018404

ChaC, cation transport regulator homolog 2 (E. coli) CHAC2 1,327651 1,2979562 1,5477625 1,2714885 chaperonin containing TCP1, subunit 2 (beta) CCT2 1,3280332 1,4762317 1,4492533 1,5274004 chaperonin containing TCP1, subunit 5 (epsilon) CCT5 1,3496335 1,6606221 1,548999 1,5889499 chemokine (C-C motif) ligand 2 CCL2 2,7808259 4,908471 1,35786 1,773338 chemokine (C-C motif) ligand 28 CCL28 -1,118242 -1,3191186 -1,5715559 -1,2877997 chemokine (C-C motif) ligand 5 CCL5 1,0417631 1,188697 2,7747867 1,820696 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) CXCL1 5,61343 3,0562267 1,442107 1,5534401 chemokine (C-X-C motif) ligand 16 CXCL16 1,138252 1,695506 1,0138177 1,0321764 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) CXCL6 1,9378659 2,181792 1,2948043 -1,1548493 chemokine (C-X-C motif) receptor 2 CXCR2 -1,0506345 -1,2790401 -1,4199924 -1,5644062 chemokine (C-X-C motif) receptor 7 CXCR7 -1,0774684 -1,3269622 -1,4942179 -1,526874 chitinase 3-like 1 (cartilage glycoprotein-39) CHI3L1 -1,2168913 1,0947732 1,2376112 4,4756875 chitinase 3-like 2 CHI3L2 -1,0994556 1,3193632 2,0025976 3,6702645 chitobiase, di-N-acetyl- CTBS 1,1270311 1,317226 1,3623878 1,7252429 chloride channel accessory 2 CLCA2 1,5406916 1,692863 2,35033 2,5275974 chloride channel accessory 4 CLCA4 1,2967209 -1,3130735 1,1725912 2,4750767 chloride intracellular channel 4 CLIC4 1,0743238 1,4293932 1,7344513 1,8557386 choline kinase alpha CHKA 1,0786556 -1,5439316 -1,096453 -1,2728211 cholinergic receptor, muscarinic 1 CHRM1 1,0081469 1,5066067 1,1051443 -1,203668 cholinergic receptor, nicotinic, beta 1 (muscle) | fibroblast growth factor 11 CHRNB1|FGF11 -1,0716728 -1,8270944 -1,2210293 -1,3203884 chondroitin sulfate proteoglycan 4 pseudogene 5 CSPG4P5 -1,7484101 1,2282101 -1,0020514 -1,1734875 chondroitin sulfate synthase 1 CHSY1 1,8922918 2,4664986 2,5053287 1,8451298 chromobox homolog 6 CBX6 1,105992 -1,7080569 -1,7347633 -1,9471182 chromodomain helicase DNA binding protein 1 CHD1 1,4573808 1,153964 1,2919705 1,6982166 chromodomain helicase DNA binding protein 3 CHD3 -1,1064373 -1,5142359 -1,4597777 -1,5978048 chromosome 1 open reading frame 101 C1orf101 -1,0374988 -1,74355 -1,4559773 -1,4889989 chromosome 1 open reading frame 110 C1orf110 -1,0199529 -2,2811422 -2,0547738 -2,1215193 chromosome 1 open reading frame 113 C1orf113 -1,5438015 -2,2175078 -1,4286134 -1,5522776 chromosome 1 open reading frame 116 C1orf116 -1,5764039 -1,9687848 -1,5342603 -1,7883649 chromosome 1 open reading frame 163 C1orf163 1,1659236 1,5000926 1,3111163 1,2615088 chromosome 1 open reading frame 183 C1orf183 1,108157 -1,2077291 -1,5096035 -1,5844209 chromosome 1 open reading frame 210 C1orf210 -1,0140641 -1,8030919 -1,24091 -1,1108172 chromosome 1 open reading frame 26 C1orf26 1,0905293 -1,7202873 -1,0536878 1,0798613 chromosome 1 open reading frame 63 C1orf63 1,0555283 -1,5659038 -1,201777 -1,1709026 chromosome 1 open reading frame 74 C1orf74 -1,2024436 1,1079319 1,5041463 1,8217223 chromosome 1 open reading frame 85 C1orf85 -1,1008657 -1,6932099 -1,0309653 1,2123147 chromosome 10 open reading frame 10 C10orf10 1,5822496 1,2595394 1,4889644 1,2577975 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 chromosome 10 open reading frame 113 C10orf113 -1,1734872 -1,5496995 -1,3417454 -1,1053375 chromosome 10 open reading frame 116 | ankyrin repeat and GTPase domain Arf GTPase activating protein C10orf116|AGAP 11 11 -1,2325264 -1,0560521 -1,526717 -1,9083582 chromosome 10 open reading frame 18 C10orf18 1,55639 1,3318777 -1,0008922 1,2429944 chromosome 10 open reading frame 26 C10orf26 1,0633345 1,2580956 1,6411476 1,3830667 chromosome 10 open reading frame 78 C10orf78 -1,0620348 -1,0058094 1,132853 1,505033 chromosome 10 open reading frame 99 C10orf99 1,4630914 1,0246671 1,4067034 1,5199049 chromosome 11 open reading frame 17 C11orf17 1,7727085 3,4665003 2,9853182 3,042043 chromosome 11 open reading frame 24 C11orf24 1,16308 1,0764973 1,213357 1,5551878 chromosome 11 open reading frame 52 C11orf52 -1,0033942 -1,6523362 -1,3391 -1,3644824 chromosome 11 open reading frame 67 | integrator complex subunit 4 C11orf67|INTS4 -1,0981264 -1,5529006 -1,3604318 -1,1474323 chromosome 11 open reading frame 80 | RCE1 homolog, prenyl protein peptidase (S. cerevisiae) C11orf80|RCE1 -1,0363243 -1,5511518 -1,0674254 -1,1619362 chromosome 11 open reading frame 82 C11orf82 -1,010924 -1,073683 1,3495349 1,5729002 chromosome 11 open reading frame 92 C11orf92 1,5891248 -1,1578392 -1,4881266 -2,0388703 chromosome 12 open reading frame 26 C12orf26 -1,0162214 -1,7224959 -1,3352095 -1,1945848 chromosome 12 open reading frame 35 C12orf35 -1,0942366 -2,1979914 -1,7081348 -1,735339 chromosome 12 open reading frame 48 C12orf48 1,2480977 -1,5821195 1,0836279 1,3158183 chromosome 12 open reading frame 5 C12orf5 1,1070383 1,2017574 1,53709 1,4248207 chromosome 12 open reading frame 51 C12orf51 -1,0617245 -1,5121212 -1,399259 -1,2237877 chromosome 12 open reading frame 51 C12orf51 -1,0340357 -1,7320567 -1,3144987 -1,2711214 chromosome 12 open reading frame 75 C12orf75 1,0952295 1,4651208 1,7078966 1,9654598 chromosome 13 open reading frame 27 C13orf27 -1,0611825 1,0064889 1,2302887 1,6093394 chromosome 13 open reading frame 34 | DIS3 mitotic control homolog (S. cerevisiae) C13orf34|DIS3 1,0094066 -1,5592765 1,0072943 1,1545813 chromosome 14 open reading frame 1 C14orf1 1,1075078 1,0306076 1,7528064 1,6475526 chromosome 14 open reading frame 126 C14orf126 1,5475222 1,0538687 -1,2462814 1,045399 chromosome 14 open reading frame 128 C14orf128 1,1482062 1,5822796 1,2929568 1,2195472 chromosome 14 open reading frame 129 C14orf129 1,6620454 1,5473831 1,7473772 1,7865075 chromosome 14 open reading frame 159 C14orf159 1,0767354 -1,3365875 -1,5020721 -1,4322618 chromosome 14 open reading frame 33 C14orf33 1,9797807 3,356253 3,349213 2,9060137 chromosome 14 open reading frame 4 C14orf4 1,1922288 1,228911 1,4539831 1,6918148 chromosome 14 open reading frame 43 C14orf43 -1,3460348 -1,6058007 -1,357895 -1,183807 chromosome 15 open reading frame 23 C15orf23 -1,1511062 -1,5187339 -1,030402 1,3253365 chromosome 15 open reading frame 41 C15orf41 1,2864128 -1,237841 -1,653981 -1,5406784 chromosome 15 open reading frame 42 C15orf42 -1,261932 -1,9326758 1,2547457 1,3621289 chromosome 15 open reading frame 52 C15orf52 -1,132375 -1,7434647 -1,4969213 -1,4924405 chromosome 15 open reading frame 62 C15orf62 1,5020885 -1,1037662 -1,2989334 -1,1078974 chromosome 17 open reading frame 28 C17orf28 -1,0976851 -1,0397136 -1,1389114 -1,5693389 chromosome 17 open reading frame 57 C17orf57 1,1688595 1,5289019 3,4367013 3,8843317 chromosome 17 open reading frame 58 C17orf58 -1,0382583 -1,5780497 -1,3760557 -1,1130553 chromosome 17 open reading frame 62 C17orf62 1,0951136 1,3319411 1,4094315 1,6513536 chromosome 17 open reading frame 69 C17orf69 -1,041416 -1,5634348 -1,5594007 -1,3871732 chromosome 18 open reading frame 21 C18orf21 1,1795319 1,3295089 1,5441 1,8315983 chromosome 2 open reading frame 15 | mitochondrial ribosomal protein L30 C2orf15|MRPL30 -1,0985936 -1,9920958 -1,262393 -1,1781309 chromosome 20 open reading frame 111 C20orf111 1,2255241 -1,5702542 -1,2126161 -1,0443828 chromosome 20 open reading frame 165 C20orf165 1,0284255 -1,5440654 -1,5970836 -1,2673328 chromosome 20 open reading frame 54 C20orf54 1,864947 1,8211552 1,6238979 1,7578294 chromosome 21 open reading frame 15 C21orf15 -1,0393562 -1,7022903 -1,4088726 -1,1762804 chromosome 22 open reading frame 37 C22orf37 -1,1727439 1,1608801 -1,1086956 -1,5424937 chromosome 3 open reading frame 26 C3orf26 1,4883318 1,7359757 1,3610407 1,2769138 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 chromosome 3 open reading frame 36 C3orf36 1,0299252 1,6196756 1,1418374 -1,1177871 chromosome 3 open reading frame 52 C3orf52 1,207975 -1,7618965 -1,7554849 -1,4860942 chromosome 3 open reading frame 57 C3orf57 -1,3454325 -1,2454364 -1,3217896 -1,86429 chromosome 3 open reading frame 64 C3orf64 1,2766559 -1,0209843 1,1994753 1,5621724 chromosome 4 open reading frame 3 C4orf3 -1,6945912 -1,0905186 -1,0712988 -1,2864141 chromosome 4 open reading frame 33 C4orf33 -1,1023349 -1,914466 -1,1378785 -1,0366135 chromosome 4 open reading frame 36 C4orf36 1,2738787 1,3669018 1,5767843 1,3354809 chromosome 5 open reading frame 13 C5orf13 1,0043584 -1,1533837 1,6178421 1,4819505 chromosome 5 open reading frame 32 C5orf32 1,2502842 1,0795691 1,6346822 1,5910468 chromosome 5 open reading frame 34 C5orf34 1,0351028 -1,546546 1,0098767 1,1965405 chromosome 5 open reading frame 36 C5orf36 1,575536 -1,4633036 -1,1691372 1,1155015 chromosome 5 open reading frame 36 C5orf36 1,3402858 -1,604161 1,0118266 -1,2014811 chromosome 5 open reading frame 41 C5orf41 -1,0068839 -1,51939 -1,2673223 -1,1864982 chromosome 5 open reading frame 43 C5orf43 1,1283158 -1,0433775 1,1604655 1,628276 chromosome 5 open reading frame 54 C5orf54 -1,0716076 -2,056545 -1,2001855 -1,1571203 chromosome 6 open reading frame 105 C6orf105 -1,092041 1,0600219 1,581961 1,9337794 chromosome 6 open reading frame 108 C6orf108 1,274587 1,5350109 1,2597293 1,1161029 chromosome 6 open reading frame 115 C6orf115 -1,0217344 -1,2696836 1,0718318 1,5405937 chromosome 6 open reading frame 125 C6orf125 1,347208 1,4963034 1,5448055 1,544049 chromosome 6 open reading frame 130 C6orf130 -1,1172006 -1,571679 -1,2875103 1,0192145 chromosome 6 open reading frame 141 C6orf141 -1,0743895 -1,8633894 1,0060469 1,0323805 chromosome 6 open reading frame 145 C6orf145 -1,0470629 -1,5183454 -1,1681874 1,069586 chromosome 6 open reading frame 150 C6orf150 2,281971 2,0092473 2,2397425 2,0169356 chromosome 6 open reading frame 155 C6orf155 1,2921119 -1,3758383 -1,2295156 -1,504303 chromosome 6 open reading frame 162 C6orf162 1,5079976 1,0439218 -1,1836208 -1,1256804 chromosome 6 open reading frame 192 C6orf192 1,5797164 -1,1021883 -1,2133358 1,0503242 chromosome 6 open reading frame 62 C6orf62 -1,0289725 -1,2524415 1,1307002 1,5488003 chromosome 7 open reading frame 68 C7orf68 -1,8970755 -1,7731627 -1,6408471 -1,3558652 chromosome 8 open reading frame 55 C8orf55 -1,1671755 -1,5257922 -1,1341205 -1,2818799 chromosome 8 open reading frame 73 C8orf73 1,0961479 1,140285 1,5791855 2,3780935 chromosome 8 open reading frame 79 C8orf79 1,5020121 1,6717209 2,1076286 2,1920712 chromosome 8 open reading frame 79 C8orf79 1,2673115 1,5352484 1,63134 1,8642075 chromosome 9 open reading frame 106 C9orf106 -1,0714475 1,0729018 -1,420459 -1,6580707 chromosome 9 open reading frame 150 C9orf150 1,7495455 1,7642274 3,108052 3,9736996 chromosome 9 open reading frame 152 C9orf152 1,0121651 -1,2784767 -1,5287094 -1,5161003 chromosome 9 open reading frame 21 C9orf21 1,2506471 1,5580091 2,0202463 2,5356836 chromosome 9 open reading frame 30 | transmembrane protein with EGF-like and two follistatin-like domains 1 C9orf30|TMEFF1 1,1498218 1,2818605 1,4107523 1,6239517 chromosome 9 open reading frame 46 C9orf46 1,3431808 1,4000131 1,3253124 1,7136986 chromosome 9 open reading frame 64 C9orf64 1,2429242 1,0773616 1,4297239 1,5278533 chromosome 9 open reading frame 84 C9orf84 3,0837958 4,8104644 6,8523574 10,695259 chromosome 9 open reading frame 85 C9orf85 1,0077544 -1,5276256 -1,357213 -1,0326309 chromosome 9 open reading frame 89 C9orf89 1,2265055 1,1150854 1,2590873 1,5128471 chromosome 9 open reading frame 95 C9orf95 1,071773 -1,5027684 1,1939931 1,4372083 chromosome X open reading frame 18 CXorf18 -1,0511487 1,5252064 -1,0466431 -1,1883973 chromosome X open reading frame 56 pseudogene LOC728024 -1,1502601 -1,5567646 1,0639043 -1,3507848 chromosome X open reading frame 64 CXorf64 -1,0708945 1,02468 1,0262563 -1,5264177 cingulin CGN -1,2958326 -1,4072591 -1,7996756 -1,4416871 cirrhosis, autosomal recessive 1A (cirhin) CIRH1A 1,3823967 1,6635237 1,2744809 1,4705584 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31

CKLF-like MARVEL transmembrane domain containing 6 CMTM6 1,2330227 1,5471365 1,6335803 1,5667683

CKLF-like MARVEL transmembrane domain containing 7 CMTM7 1,0021832 1,6474284 1,600885 1,5015663 class II, major histocompatibility complex, transactivator CIITA 1,6732548 1,5949603 -1,0947239 -1,0213349 clathrin interactor 1 CLINT1 1,0302391 -1,3757282 -1,5442225 -1,8330917 claudin 1 CLDN1 -1,0902764 1,1539007 -1,6285323 -1,833619 claudin 16 CLDN16 -1,1085018 -1,168734 -1,7956982 -2,6607656 claudin 8 CLDN8 1,1341778 -1,7369474 -1,4158823 -1,3419622 clusterin CLU 1,411074 -1,2522669 -3,0474954 -3,1148179

CMT1A duplicated region transcript 1 | F-box and WD repeat domain containing 10 CDRT1|FBXW10 1,7390062 -1,1141628 -1,2383877 1,0484986

CMT1A duplicated region transcript 1 | F-box and WD repeat domain containing 10 CDRT1|FBXW10 1,4853665 1,1757439 -1,5432806 1,1991075 CDRT15|CDRT1 CMT1A duplicated region transcript 15 | CMT1A duplicated region transcript 15 pseudogene 5P -1,3327823 1,5786517 -1,085534 -1,3322 coagulation factor II (thrombin) receptor F2R 1,103625 1,2108303 1,8158443 1,8146222 coagulation factor II (thrombin) receptor-like 1 F2RL1 3,2593603 2,4226253 2,5154746 2,6617613 coagulation factor III (thromboplastin, tissue factor) F3 1,0537328 2,0052476 1,1027907 1,2235612 coagulation factor V (proaccelerin, labile factor) F5 -1,1041058 1,1320124 4,4841056 14,151075

COBL-like 1 COBLL1 1,0536171 -1,4599099 -1,3706613 -1,5511662 cofilin 1 (non-muscle) CFL1 1,0154268 1,4914558 1,5681267 1,3597723 CCDC109B|CAS coiled-coil domain containing 109B | caspase 6, apoptosis-related cysteine peptidase P6 1,3308411 2,3643281 2,0030808 2,0285478 coiled-coil domain containing 121 CCDC121 1,0318247 1,0050292 1,0722404 -1,5299716 coiled-coil domain containing 146 CCDC146 1,5110396 -1,118811 -1,368123 -1,7941196 coiled-coil domain containing 34 CCDC34 -1,1191734 -1,5187368 1,0611783 -1,0591981 coiled-coil domain containing 80 CCDC80 -1,5519056 -2,5258353 -3,8266928 -6,0807247 coiled-coil domain containing 82 CCDC82 -1,0271139 -1,6352555 -1,309056 -1,296084 coiled-coil domain containing 82 CCDC82 1,0779232 -1,682886 -1,3910239 -1,1818175 coiled-coil domain containing 84 CCDC84 1,0396253 -1,3336107 -1,535294 -1,7117893 coiled-coil domain containing 86 CCDC86 1,3299717 1,8953156 1,2541379 1,1262677 coiled-coil domain containing 88A CCDC88A 1,0132188 1,0056483 1,2317282 1,5639429 coiled-coil domain containing 88C CCDC88C 1,5613223 1,0908296 -1,0783654 1,9128234 collagen, type IV, alpha 5 COL4A5 1,3168482 -1,2780213 -1,3560574 -1,63727 collagen, type XI, alpha 2 COL11A2 -1,229208 1,033018 -1,6687205 -1,7256335 collagen, type XI, alpha 2 COL11A2 -1,2347674 1,0444647 -1,725544 -1,7137412 collectin sub-family member 12 COLEC12 1,0462278 1,0215499 1,6068403 1,3416159 complement component 1, q subcomponent binding protein C1QBP 1,2617486 1,5099787 1,2819935 1,3049297 complement component 1, q subcomponent, C chain C1QC -1,0252329 1,0346633 1,0877637 -1,6416543 complement component 1, r subcomponent C1R -1,0700507 1,3050557 2,5666645 2,805805 complement component 1, r subcomponent-like C1RL 1,1006104 1,3770057 1,7085809 1,9146636 complement component 1, s subcomponent C1S -1,0732924 1,1252475 1,9098499 2,9479136 complement component 5 C5 1,7516174 -1,0020854 -1,1675513 -1,3619565 complement factor B CFB 1,128311 2,304198 2,9084044 3,8293777 complement factor B CFB 1,121742 2,23038 2,8554282 3,6584802 complement factor B CFB 1,2345797 2,0938144 2,7862558 3,3306277 complement factor H CFH 1,4463047 2,1223392 1,9785973 1,5000867 complement factor H-related 1 CFHR1 1,1023728 1,5976232 1,4511504 1,2145643 CNTNAP3|CNTN contactin associated protein-like 3 | contactin associated protein-like 3B AP3B 1,598946 -1,1949342 1,2296073 1,1543906 CNTNAP3|CNTN contactin associated protein-like 3 | contactin associated protein-like 3B AP3B 1,5845037 -1,1812813 1,2402097 1,1363624 CNTNAP3|CNTN contactin associated protein-like 3 | contactin associated protein-like 3B CNTNAP3|CNTNAP3B 1,5798235 -1,1810503 1,2412349 1,1356201 contactin associated protein-like 3 | contactin associated protein-like 3B | contactin associated protein-like 3 AP3B|LOC64379 pseudogene 2 1,5120513 -1,0925584 1,1736156 1,2587528 copine VIII CPNE8 2,6282744 4,8043933 3,7518888 4,063407 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 C1GALT1 1,1054116 1,3633797 2,0499873 1,9759276 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 CBFA2T2 -1,033141 -1,6174529 -1,479015 -1,3582761 coronin 6 CORO6 1,0733026 -1,789938 -1,50576 -1,3051717

COX19 cytochrome c oxidase assembly homolog (S. cerevisiae) | ArfGAP with dual PH domains 1 COX19|ADAP1 -1,3913504 -1,6124765 -1,157709 -1,1550363 coxsackie virus and adenovirus receptor CXADR 1,1156781 1,7287945 1,8964542 1,5166701

CREB/ATF bZIP transcription factor CREBZF -1,0518023 -1,7060918 -1,5319177 -1,2173853 crystallin, gamma N CRYGN -1,3657448 1,2296935 -1,0886376 -1,5367298

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like CTDSPL -1,095283 -1,7603614 -1,5890224 -1,6329843

CTP synthase CTPS 2,1600225 2,2624166 1,7122328 1,6974202

CUB domain containing protein 1 CDCP1 -1,0819917 1,2672955 1,4380137 1,7690914 cullin 4B CUL4B -1,0056525 -1,5668356 -1,0518224 -1,0149401

CXXC finger protein 5 CXXC5 -1,3822559 -1,9637132 -1,2686492 -1,4490359 cyclin B1 CCNB1 1,0392233 -1,4175456 1,1790011 1,5245255 cyclin B2 CCNB2 -1,1788094 -1,5172457 1,0008858 1,7975105 cyclin C CCNC 1,1109666 1,0850035 1,5295888 1,4272933 cyclin F CCNF -1,0614485 -1,68565 -1,1277047 -1,0915571 cyclin L1 CCNL1 1,5824071 1,1133257 1,1097467 1,352756 cyclin M4 CNNM4 -1,1714128 -1,6839855 -1,2373294 -1,3251622 cyclin Y-like 1 CCNYL1 1,192131 1,2648509 1,6802871 1,7647172 cyclin-dependent kinase 1 CDK1 -1,0538021 -1,2045248 1,3487941 1,5114326 cyclin-dependent kinase 7 CDK7 -1,0708234 1,2338682 1,8157867 1,6618773 cyclin-dependent kinase 7 CDK7 -1,0835291 1,2319399 1,8119265 1,6668386 cyclin-dependent kinase inhibitor 1A (p21, Cip1) CDKN1A 1,0027087 -1,1502163 1,3060223 1,6969491 cyclin-dependent kinase inhibitor 3 CDKN3 1,0799531 -1,5124587 -1,0304049 1,707362 cystatin A (stefin A) CSTA -1,2899083 -1,9131947 -1,6285323 -1,1852376 cystatin C CST3 1,0491018 1,0375341 1,3097425 1,604072 cysteine and histidine-rich domain (CHORD)-containing 1 CHORDC1 1,8334372 1,3356116 -1,0438983 1,2401519 cysteine rich transmembrane BMP regulator 1 (chordin-like) CRIM1 1,5053684 1,2999457 1,0523517 -1,0207784 cysteine-rich protein 2 CRIP2 -1,4179242 -1,6305045 -1,021101 1,0625756 cysteine-rich secretory protein LCCL domain containing 2 CRISPLD2 1,0063063 1,1653553 1,574953 1,3619438 cysteine/histidine-rich 1 CYHR1 1,1271675 -1,5443951 -1,1400672 -1,0965194 cytidine deaminase CDA -1,4541792 -2,5763783 -1,5275477 -1,1582043 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial CMPK2 1,0185009 1,7191812 1,3583682 1,3592906 cytochrome b, ascorbate dependent 3 CYBASC3 1,0128732 -1,8227907 -1,7800394 -1,4218465 cytochrome b5 reductase 1 CYB5R1 -1,2227348 -1,6658633 -1,306283 -1,2469851 cytochrome c oxidase subunit VIb polypeptide 2 (testis) COX6B2 -1,2426367 -1,0089862 1,2088118 1,6405077 cytochrome c, somatic CYCS 1,7778239 1,3558536 -1,2277361 -1,0837017 cytochrome P450, family 1, subfamily A, polypeptide 1 CYP1A1 -1,4796883 1,077174 -1,0296869 -1,5511421 cytochrome P450, family 2, subfamily F, polypeptide 1 CYP2F1 -1,0470836 1,0149761 -1,2842616 -1,5895655 cytochrome P450, family 24, subfamily A, polypeptide 1 CYP24A1 -1,1467105 3,262031 3,6321785 7,350301 cytochrome P450, family 27, subfamily B, polypeptide 1 CYP27B1 1,2975873 3,1974766 4,0783124 4,1008744 cytochrome P450, family 3, subfamily A, polypeptide 5 CYP3A5 -1,0495249 -5,2411695 -4,6180215 -4,134784 cytochrome P450, family 4, subfamily B, polypeptide 1 CYP4B1 -1,0041951 -3,2016168 -3,9393294 -5,8137856 cytochrome P450, family 4, subfamily F, polypeptide 11 CYP4F11 -1,1881542 -1,3215939 1,8035556 2,0385692 cytochrome P450, family 4, subfamily F, polypeptide 12 CYP4F12 -1,2525045 -3,9355671 -2,7314832 -2,6377752 cytochrome P450, family 4, subfamily F, polypeptide 3 CYP4F3 -1,445028 -4,252784 -3,378489 -2,5171738 cytochrome P450, family 4, subfamily F, polypeptide 8 CYP4F8 1,0108101 -2,0889542 -2,302813 -1,3412057 cytochrome P450, family 4, subfamily V, polypeptide 2 CYP4V2 1,2975582 1,5880893 1,4255832 1,418595 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 cytochrome P450, family 4, subfamily X, polypeptide 1 CYP4X1 1,2095195 -1,4052726 -1,8670982 -1,7907072 cytochrome P450, family 4, subfamily Z, polypeptide 1 CYP4Z1 1,1587718 1,0644889 -1,1078389 -1,5082923 cytochrome P450, family 51, subfamily A, polypeptide 1 CYP51A1 1,1236504 1,4655436 3,6237247 3,1497612 cytoglobin CYGB -1,5823642 1,0775114 -1,0808543 -1,18871 cytohesin 1 CYTH1 1,1413019 1,2421238 1,3618034 1,5144991 cytohesin 2 CYTH2 -1,062976 -1,5878117 -1,1936207 -1,1186202 cytohesin 4 CYTH4 -1,2062097 1,3259671 1,7822883 1,7010355 cytoplasmic polyadenylation element binding protein 2 CPEB2 -1,5249665 -2,487493 -1,2150815 1,0334879 cytoplasmic polyadenylation element binding protein 3 CPEB3 -1,0119523 -1,8731879 -1,4755664 -1,451585 cytoskeleton associated protein 2 CKAP2 -1,0171337 -1,673366 1,0626626 1,2269353 cytoskeleton associated protein 2-like CKAP2L 1,0425743 -1,5207024 -1,0337193 1,4544564 damage-specific DNA binding protein 2, 48kDa DDB2 -1,0439197 -1,5667725 -1,2726995 -1,150186 DCUN1D3|LYRM DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae) | LYR motif containing 1 1 1,6885378 2,4704752 2,273743 2,3836193 dCTP pyrophosphatase 1 DCTPP1 1,2044005 1,6180838 1,0296434 1,0070755

DDB1 and CUL4 associated factor 6 DCAF6 -1,079457 -1,5263395 -1,1657798 -1,0537001 de-etiolated homolog 1 (Arabidopsis) DET1 1,0389156 -1,217246 -1,7476735 -1,3195311

DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 DDX21 1,9720417 2,325008 1,6333092 2,0326679

DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 DDX28 1,0152748 1,0328399 1,0841184 1,8206755

DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 DDX58 1,6650529 1,1324401 1,198323 2,1216238

DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 DDX60 1,439092 1,1031349 -2,1202161 1,8778942

DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like DDX60L 1,4091222 -1,0950543 -1,1082952 2,1370146 deafness, autosomal dominant 5 DFNA5 1,1723559 1,5269859 2,4412775 2,1928167

DEAQ box RNA-dependent ATPase 1 DQX1 -1,1140738 -1,7125385 -1,073755 -1,408401 death associated protein-like 1 DAPL1 1,3056977 -2,5091107 -2,7751122 -2,3518782 death-associated protein kinase 1 DAPK1 -1,1943562 1,2126802 2,2023952 2,404458 death-associated protein kinase 2 DAPK2 -1,6648648 1,082589 -1,2617619 -1,4315628 dedicator of cytokinesis 11 DOCK11 1,242082 -1,0893215 1,6023705 1,6628443 DEFB103A|DEF defensin, beta 103A | defensin, beta 103B B103B -1,0724502 1,1497842 1,1010244 4,159586 DEFB103A|DEF defensin, beta 103A | defensin, beta 103B B103B -1,071614 1,1609468 1,0999244 4,1413517 defensin, beta 4A DEFB4A -1,0846767 1,0394593 1,3317853 1,9507402 defensin, beta 4A DEFB4A -1,0805293 1,0312343 1,3207053 1,9465648 dehydrogenase/reductase (SDR family) member 3 DHRS3 1,164941 -2,1263583 -2,5338473 -2,558388 dehydrogenase/reductase (SDR family) member 7 DHRS7 1,0117015 1,2786715 2,8913724 4,0885735 deiodinase, iodothyronine, type II DIO2 1,0251899 1,1778252 2,8651278 2,4939077 deleted in lymphocytic leukemia 2 (non-protein coding) DLEU2 1,1922505 -1,7043096 1,0085578 1,3963327 deleted in malignant brain tumors 1 DMBT1 -1,0358691 1,5229744 1,4691384 1,129452 deltex 3-like (Drosophila) | poly (ADP-ribose) polymerase family, member 9 DTX3L|PARP9 1,252994 1,3461424 1,1702813 1,5195341 deltex homolog 4 (Drosophila) DTX4 -1,399915 -2,2830052 -2,0678396 -2,2766747

DENN/MADD domain containing 1B DENND1B 1,0665145 -1,5047246 -1,348824 -1,1392592

DENN/MADD domain containing 1B DENND1B 1,0889575 -1,5858124 -1,3358169 -1,3206812

DENN/MADD domain containing 2D DENND2D 1,54118 1,5865129 1,3749074 1,1538146

DENN/MADD domain containing 4C DENND4C -1,0791674 -1,5797963 -1,3579067 -1,4144566 denticleless homolog (Drosophila) DTL 1,1366888 1,2042482 1,6226318 1,7783605

DEP domain containing 1 DEPDC1 1,0006825 -2,1609921 1,0218775 1,919941

DEP domain containing 1B DEPDC1B 1,3164252 -1,5152156 1,009772 1,0789348

DEP domain containing 4 DEPDC4 -1,195739 -1,5115541 -1,0264901 -1,0918819 desmocollin 1 DSC1 -1,1359065 -1,469083 -1,1424572 -1,8592836 desmocollin 2 DSC2 -1,3641821 -2,2771738 -1,1868668 -1,3013574 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 desmoglein 1 DSG1 -2,1860015 -9,134738 -6,224564 -18,023237 desmoglein 4 DSG4 -1,159143 -12,684307 -12,136004 -10,673192 desmoplakin DSP -1,2354622 -1,7026976 -1,0857698 -1,1495907 diacylglycerol kinase, epsilon 64kDa DGKE 1,056933 -1,615088 -1,2577639 1,0202644 diacylglycerol O-acyltransferase 2 DGAT2 -1,1890243 1,5411204 1,3000957 1,1012201 diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) DBI -1,0003226 -1,6741029 -1,3552765 -1,4107981 dicer 1, ribonuclease type III DICER1 1,2214035 1,273334 1,4295443 1,5033387 dickkopf homolog 1 (Xenopus laevis) DKK1 -1,4688709 -1,7284887 -1,5251741 -1,5390105

DiGeorge syndrome critical region gene 2 DGCR2 -1,0980487 -1,4486777 -1,2725825 -1,5122002 dihydropyrimidinase-like 3 DPYSL3 1,206592 1,5808482 1,3154387 -1,0529884 dipeptidyl-peptidase 4 DPP4 -1,1144162 -1,1001186 1,0704709 1,6944416 dipeptidyl-peptidase 6 DPP6 -1,025864 -1,0233011 -1,2704439 -2,009869 discoidin domain receptor tyrosine kinase 1 DDR1 -1,0807022 -1,2401342 -1,5796658 -1,6219283 discoidin domain receptor tyrosine kinase 1 DDR1 -1,0809929 -1,2396433 -1,5988952 -1,6560049 discoidin domain receptor tyrosine kinase 1 DDR1 -1,0592408 -1,2981114 -1,6282965 -1,6892445 discs, large (Drosophila) homolog-associated protein 5 DLGAP5 -1,0292882 -1,8034656 -1,0287634 1,5717107 discs, large homolog 3 (Drosophila) DLG3 -1,1976242 -1,745087 -1,2785959 -1,2910608 dishevelled associated activator of morphogenesis 1 DAAM1 -1,1319836 -1,8475146 -1,5138665 -1,6712358 distal-less homeobox 2 DLX2 -1,2237892 -1,3456455 -1,5616965 -1,6879581 distal-less homeobox 5 DLX5 -1,6040146 -1,4285458 -1,299691 -2,2643144

Dmx-like 1 DMXL1 1,1216872 -1,6647348 -1,1877521 -1,0858788

Dmx-like 2 DMXL2 1,1680658 -1,508921 -1,2409203 1,0057546

DNA replication helicase 2 homolog (yeast) DNA2 -1,0617245 -1,5246555 -1,3509942 -1,2433914

DNA-damage-inducible transcript 3 DDIT3 -1,0424088 -1,0740553 1,1616236 1,6727047

DNA-damage-inducible transcript 4 DDIT4 -2,0803423 -2,262914 -1,3980719 -1,15854

DnaJ (Hsp40) homolog, subfamily A, member 1 DNAJA1 1,2587378 1,3369128 1,2106358 1,7912891

DnaJ (Hsp40) homolog, subfamily B, member 1 DNAJB1 1,7614539 1,5487441 1,6501489 1,2223405

DnaJ (Hsp40) homolog, subfamily B, member 11 DNAJB11 1,274443 1,2668248 1,5872808 1,4055833

DnaJ (Hsp40) homolog, subfamily B, member 2 DNAJB2 -1,1685423 -1,467598 -1,5330782 -1,3545183 DnaJ (Hsp40) homolog, subfamily C , member 25 | DNAJC25-GNG10 readthrough | guanine nucleotide DNAJC25|DNAJ binding protein (G protein), gamma 10 C25-GNG10 1,2212307 1,5593497 1,2350596 1,2297993

DnaJ (Hsp40) homolog, subfamily C, member 28 DNAJC28 -1,1743524 -1,626815 -1,3272161 -1,0915066 docking protein 4 DOK4 -1,2575107 -1,7929968 -1,0539091 -1,140728 double homeobox 4 like 4 | double homeobox 4 like 7 DUX4L4|DUX4L7 1,056593 1,298802 -1,2323053 -1,5221924 double homeobox 4 like 4 | double homeobox 4 like 7 | double homeobox 4 like 3 | double homeobox 4 like 5 | |DUX4L3|DUX4L double homeobox 4 like 6 5|DUX4L6 -1,1311817 1,5074346 -1,0203046 -1,1800619 dpy-19-like 1 (C. elegans) DPY19L1 1,044191 1,3711661 1,5229914 1,5349125 dual adaptor of phosphotyrosine and 3-phosphoinositides DAPP1 -1,0798274 -1,6793488 -1,7397426 -2,0242853 dual oxidase 1 DUOX1 -1,338438 -2,1143448 -1,6753461 -1,8041142 dual oxidase 2 DUOX2 -1,1362509 -1,7810569 -2,1325066 -2,1742628 DUOXA1|DUOX dual oxidase maturation factor 1 | dual oxidase maturation factor 2 A2 -1,2622825 -1,792985 -1,5417084 -1,5448239 dual specificity phosphatase 10 DUSP10 -1,6274205 -2,2441769 -1,7190078 -1,1143345 dual specificity phosphatase 14 DUSP14 -1,1641319 -1,5762403 -1,2663137 -1,2365962 dual specificity phosphatase 6 DUSP6 1,8995545 5,371237 5,8451123 9,810455 dual specificity phosphatase 7 DUSP7 -1,2751441 1,1517061 1,4125216 1,7139168 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 DYRK3 1,164372 1,5390588 1,8848089 1,6831146 dynactin 6 DCTN6 1,1816773 1,2454734 1,2807678 2,0529816 dynamin 1 pseudogene C15orf51 -1,266038 -1,566701 -1,099255 1,0637885 dynamin 1 pseudogene C15orf51 -1,2663602 -1,5672987 -1,100459 1,0630238 dynamin 1 pseudogene C15orf51 -1,2475895 -1,58887 1,0067847 1,09749 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 dynamin 1 pseudogene C15orf51 -1,2468796 -1,5909542 1,0067234 1,0986665 dynamin 1-like DNM1L 1,173555 1,4381135 1,465391 1,6726085 dynamin binding protein DNMBP -1,2754898 -1,5569097 -1,5449679 -1,5407405 dynein heavy chain domain 1 DNHD1 1,2283652 -1,5668149 -1,0182418 1,2695687 dynein, cytoplasmic 2, heavy chain 1 DYNC2H1 1,3845083 -1,264288 -1,5118629 -1,1752691 dynein, light chain, Tctex-type 3 DYNLT3 1,7870585 3,081868 1,6369648 2,1869512 dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) DYSF 1,1409236 1,1658885 4,3457193 6,451245 dyskeratosis congenita 1, dyskerin DKC1 1,4644175 2,0262325 1,4961808 1,3653016 DST|LOC100506 dystonin | bullous pemphigoid antigen 1-like 118 1,137827 -2,0002036 -1,2598125 -1,2430471 dystrophin DMD 1,3884434 -1,0781021 -1,8627803 -1,7644396

E2F transcription factor 8 E2F8 -1,1816835 -1,7278439 -1,1613871 -1,0182041

E74-like factor 3 (ets domain transcription factor, epithelial-specific ) ELF3 -1,1010338 -1,7556266 -2,1931293 -3,0189285 early growth response 1 EGR1 1,5221852 2,3011916 1,3405268 2,4072158 early lymphoid activation protein EPAG -1,1998878 -1,8215904 -1,593957 -1,422775 echinoderm microtubule associated protein like 5 EML5 1,046198 -1,2679663 1,3012487 1,8059219 ectodermal-neural cortex 1 (with BTB-like domain) ENC1 3,122271 1,2557497 -1,1550866 1,0764062 ectodysplasin A receptor EDAR 1,0753078 -1,6663082 -1,9990073 -2,030687 ectonucleoside triphosphate diphosphohydrolase 3 ENTPD3 1,179076 -1,0007654 1,3560059 1,6753976 ectonucleoside triphosphate diphosphohydrolase 6 (putative) ENTPD6 1,0937355 1,0125425 1,2043186 1,9381772 ectonucleoside triphosphate diphosphohydrolase 7 ENTPD7 -1,1264546 -1,1797799 1,2532738 1,5521355 ectonucleotide pyrophosphatase/phosphodiesterase 2 ENPP2 1,1527792 1,1127952 -1,0090686 1,7351418

EF-hand domain (C-terminal) containing 1 EFHC1 1,1911858 -1,6476909 -1,6995564 -1,3365897

EGF-containing fibulin-like extracellular matrix protein 1 EFEMP1 1,3424315 1,1276958 1,136576 -1,5325117 egf-like module containing, mucin-like, hormone receptor-like 2 EMR2 -1,1656735 1,0086108 1,4182912 1,6470685

EGF-like-domain, multiple 6 EGFL6 -1,1797004 1,0408889 -1,4464543 -2,0656052 egl nine homolog 1 (C. elegans) EGLN1 -1,5293503 1,120989 -1,1164719 -1,0051627 egl nine homolog 3 (C. elegans) EGLN3 -3,5294216 -1,3120279 -1,1890943 -1,3274689

EH-domain containing 4 EHD4 1,3143314 1,9828762 1,6705996 2,2773468 elongation factor RNA polymerase II-like 3 | protein disulfide isomerase family A, member 3 | serine ELL3|PDIA3|SER incorporator 4 INC4 1,4828417 -1,6301581 -1,1774551 -1,2801033 elongation factor, RNA polymerase II, 2 ELL2 1,0623937 -1,0038725 1,5904368 1,5346416

ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast) ELOVL5 1,3643651 1,1864259 1,8065392 1,9196466

ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast) ELOVL6 1,2234329 1,5912203 1,6097463 1,5438929 emopamil binding protein (sterol isomerase) EBP 1,2114596 -1,3675562 1,5606506 1,366422 endogenous retroviral sequence 3 ERV3 1,1643989 -1,6604487 -1,8013531 -1,5432929 endonuclease domain containing 1 ENDOD1 1,0516872 1,0979354 1,660154 1,3877006 endoplasmic reticulum metallopeptidase 1 ERMP1 1,0597452 -1,7776512 -1,5262064 -1,2201785 endothelial PAS domain protein 1 EPAS1 1,1955451 1,2978506 1,5473431 2,0622005 endothelin receptor type A EDNRA -1,1762515 1,3242139 1,290906 1,5422083 enhancer of zeste homolog 1 (Drosophila) EZH1 1,0244863 -1,6264225 -1,5754559 -1,429037 enhancer of zeste homolog 2 (Drosophila) EZH2 1,121358 -1,1268553 1,2798537 1,5319375 enkurin, TRPC channel interacting protein ENKUR -1,0470881 1,2516537 1,402019 2,0590131 enolase 1, (alpha) ENO1 -1,2196858 1,4774609 1,6665175 1,725358 enolase 2 (gamma, neuronal) ENO2 -2,9180043 -1,2560909 -1,0221555 -1,0944989 envoplakin EVPL -1,4018226 -1,6775725 -1,1845186 -1,2760439

EPH receptor A2 EPHA2 1,9206754 1,5328653 1,320346 1,4246898

EPH receptor A4 EPHA4 1,2342287 -1,9797657 -1,9659815 -2,6384194

EPH receptor B2 EPHB2 -1,0578071 -2,2418535 -1,5366058 -1,5955894

EPH receptor B3 EPHB3 -1,607456 -2,0705225 -1,4824355 -1,4864086 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31

EPH receptor B6 EPHB6 -1,1247213 -1,5234839 -1,2947239 -1,6108459 ephrin-A3 EFNA3 1,42807 1,4187201 1,6327269 1,3235898 ephrin-B2 EFNB2 1,4252352 -1,0622121 1,5701634 1,4538494 epidermal growth factor receptor pathway substrate 8 EPS8 1,1728601 -1,6260151 -1,3976135 -1,3801551 epiregulin EREG -1,6715628 1,8493848 1,2224472 1,7211063 epithelial cell transforming sequence 2 oncogene ECT2 1,0951252 -1,0101839 1,6553636 1,7958685 epithelial membrane protein 2 EMP2 -1,0108706 -1,7944398 -1,2652849 -1,3270696 epithelial mitogen homolog (mouse) EPGN 1,5532563 2,5762422 2,0383224 1,9160949 epithelial splicing regulatory protein 1 ESRP1 -1,0911517 -1,9450129 -1,0571402 -1,0263991 epithelial splicing regulatory protein 2 ESRP2 -1,2821833 -1,6475526 -1,1345966 -1,0944407 epithelial stromal interaction 1 (breast) EPSTI1 1,4003254 -1,1293494 1,0127728 1,6207001 epoxide hydrolase 2, cytoplasmic EPHX2 1,2612115 -2,4073384 -2,357314 -2,638225 epoxide hydrolase 3 EPHX3 -1,3923987 1,2629836 -1,1637018 -1,5038034

EPS8-like 2 EPS8L2 -1,305942 -2,1648483 -1,3859588 -1,4002639 epsin 3 EPN3 -1,1957552 -1,4733816 -1,571761 -1,4572349

Epstein-Barr virus induced 3 EBI3 -1,2566203 1,3300852 2,0334058 1,576407

ERBB receptor feedback inhibitor 1 ERRFI1 1,1846944 1,8700602 1,7434208 1,702777

ERO1-like (S. cerevisiae) ERO1L -2,5400136 1,1388963 1,405969 1,8406346 erythrocyte membrane protein band 4.1 like 4A EPB41L4A 1,1146762 -1,6016562 -1,3219473 -1,624161 erythrocyte membrane protein band 4.1 like 4B EPB41L4B -1,2749933 -1,8262172 -1,5542176 -1,7715915 erythrocyte membrane protein band 4.1-like 1 EPB41L1 1,3401732 1,3023264 -1,7300473 -2,174063 espin pseudogene ESPNP -1,0670335 1,0098674 -1,1053708 -1,5079708 establishment of cohesion 1 homolog 2 (S. cerevisiae) ESCO2 -1,0077767 -1,3688504 1,2905638 1,6491407 ethanolamine kinase 2 ETNK2 1,0007787 1,2045196 1,7081783 1,4920701 ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific) | G protein-coupled receptor 113 EPT1|GPR113 1,4337779 1,4072503 1,4772973 1,5187448 ethylmalonic encephalopathy 1 ETHE1 -1,1493115 -1,0408136 1,2404541 1,7550638 ets variant 4 ETV4 -1,2973218 1,3966858 1,8527907 2,7678087 ets variant 5 ETV5 -1,1224897 1,7578411 2,241445 2,7364116 ets variant 7 ETV7 1,8244809 1,6911752 1,0404513 1,1110919 eukaryotic elongation factor-2 kinase EEF2K -1,1362433 -2,356437 -1,6140084 -1,7110522 eukaryotic translation elongation factor 1 alpha 2 EEF1A2 -1,0881904 -1,2505268 1,6696143 2,6657336 eukaryotic translation initiation factor 2-alpha kinase 2 EIF2AK2 1,309933 -1,0632894 1,0327286 1,5802308 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa EIF2S2 1,5752164 1,5095336 1,4806463 1,8596597 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa EIF2B2 1,2643869 1,3950244 1,4602989 1,7900095 eukaryotic translation initiation factor 3, subunit B EIF3B 1,190638 1,5085211 1,1595308 1,2113286 eukaryotic translation initiation factor 4A1 EIF4A1 1,018266 1,4558797 1,2782836 1,6081743 eukaryotic translation initiation factor 4A3 EIF4A3 1,2036214 1,6257765 1,3317474 1,275774 eukaryotic translation initiation factor 4B EIF4B -1,093972 -1,316768 -1,0451549 1,8530105 eukaryotic translation initiation factor 5A-like 1 | eukaryotic translation initiation factor 5A EIF5AL1 1,1531237 1,6597617 1,4441236 1,5506115 eukaryotic translation initiation factor 5A-like 1 | eukaryotic translation initiation factor 5A EIF5AL1 1,1472185 1,6596465 1,4175277 1,5180342 eukaryotic translation initiation factor 5A-like 1 | eukaryotic translation initiation factor 5A EIF5AL1 1,137851 1,551521 1,4005526 1,5609884 eukaryotic translation initiation factor 5B EIF5B 1,2958404 1,5204505 1,3882511 1,3744802 excision repair cross-complementing rodent repair deficiency, complementation group 5 ERCC5 -1,0547502 -1,5154275 -1,2097498 -1,2182024 exophilin 5 EXPH5 -1,0384974 -2,8847547 -1,7728106 -1,8583429 exoribonuclease 1 ERI1 1,8353591 1,1591594 1,5049982 1,7025744 exosome component 4 EXOSC4 1,2044014 1,562722 1,2523315 1,2318968 exosome component 7 EXOSC7 1,0144653 -1,5001392 -1,2292502 -1,3038554 exostoses (multiple)-like 2 EXTL2 1,531698 -1,2310477 1,090883 1,2496269 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 exostoses (multiple)-like 3 EXTL3 1,6044834 1,0389857 1,2845527 1,3634185 exportin, tRNA (nuclear export receptor for tRNAs) XPOT 1,1885674 1,4253491 1,5397753 1,8596523 extended synaptotagmin-like protein 1 ESYT1 -1,0459436 -1,1546172 1,6961304 1,8877167 extracellular matrix protein 1 ECM1 -1,0376774 -1,360033 -1,8232812 -1,6452464

F-box and leucine-rich repeat protein 20 FBXL20 -1,0594559 -1,5334978 -1,2395433 -1,1008221

F-box and leucine-rich repeat protein 22 FBXL22 -1,3332304 1,6163253 -1,0637548 -1,0608038

F-box and WD repeat domain containing 4 pseudogene 1 FBXW4P1 1,6664315 1,2765632 1,2157195 1,1553693

F-box and WD repeat domain containing 7 FBXW7 -1,4511687 -1,9441755 -1,2607934 -1,2581518

F-box protein 10 | translocase of outer mitochondrial membrane 5 homolog (yeast) FBXO10|TOMM5 1,1116667 1,5139595 1,220565 1,2030439 FBXO25|LOC728 F-box protein 25 | hypothetical LOC728323 323 1,0911083 -1,5777164 -1,1419954 1,1380075

F-box protein 27 FBXO27 1,0669109 -1,6340215 -1,1551504 -1,0344944

F-box protein 32 FBXO32 -1,2439208 -4,200054 -2,6782072 -2,3000617

F-box protein 48 FBXO48 -1,1990076 -1,5834006 -1,0798292 1,070385

F-box protein 9 FBXO9 -1,218307 -1,1232213 1,691083 1,3100693

F-box protein 9 FBXO9 1,023017 -1,006264 1,4838507 1,6222034

F-box protein 9 FBXO9 1,226829 -1,0250994 1,4530866 1,5541642 family with sequence similarity 100, member B FAM100B 1,0942866 1,2059549 1,7896492 2,0076404 family with sequence similarity 102, member A FAM102A 1,0408335 -1,8213575 -1,7056355 -1,5648627 family with sequence similarity 102, member B FAM102B 1,0737636 -2,7655795 -2,0005488 -2,0031404 family with sequence similarity 107, member A FAM107A -1,0260105 1,6258458 1,0930644 -1,0765685 family with sequence similarity 108, member C1 FAM108C1 1,3316119 1,3329982 1,3100481 1,5840261 family with sequence similarity 111, member A FAM111A 1,2733567 -1,5477605 -1,744621 -1,2123868 family with sequence similarity 129, member A FAM129A 1,2336065 1,7938219 1,8088491 1,8641521 family with sequence similarity 129, member B FAM129B -1,1896663 2,13762 2,2019527 2,4867318 family with sequence similarity 153, member B | family with sequence similarity 153, member C | family with FAM153B|FAM15 sequence similarity 153, member A 3C|FAM153A -1,1935252 -1,5616397 -1,2361288 -1,1126772 family with sequence similarity 153, member C | family with sequence similarity 153, member A | family with FAM153C|FAM15 sequence similarity 153, member B 3A|FAM153B -1,3057379 -1,7197716 -1,2164497 -1,0565828 family with sequence similarity 162, member A FAM162A -1,5311964 -1,3210711 -1,482461 -1,2542713 family with sequence similarity 177, member A1 FAM177A1 1,5172943 1,0689418 1,1753169 1,4143496 FAM182A|FAM18 family with sequence similarity 182, member A | family with sequence similarity 182, member B 2B -1,0824263 -1,0218316 -1,3155609 -1,5166185 family with sequence similarity 20, member A FAM20A 1,0155765 1,1123146 1,0689838 1,5801059 FAM201B|LOC10 family with sequence similarity 201, member B | hypothetical protein LOC100134240 0134240 -1,0038371 1,6720922 -1,119115 -1,3275707 family with sequence similarity 27, member D1 FAM27D1 1,0422214 -1,005596 -1,0193071 -1,5403861 family with sequence similarity 43, member A FAM43A 1,4425875 1,7186443 1,8147193 1,8268691 FAM45A|FAM45 family with sequence similarity 45, member A | family with sequence similarity 45, member A pseudogene B 1,0129824 -1,8674846 -1,3210584 -1,2444694 family with sequence similarity 46, member B FAM46B -1,4908506 -1,5356183 -1,2152947 -1,1768551 family with sequence similarity 46, member C FAM46C -1,141154 1,0173029 1,423099 1,5818052 family with sequence similarity 54, member A FAM54A -1,2768209 -1,540467 -1,0801122 1,1572622 family with sequence similarity 59, member A FAM59A 1,002755 -1,6960956 -1,2476175 -1,2298374 family with sequence similarity 60, member A FAM60A 1,3680784 1,7297289 1,395385 1,9791931 family with sequence similarity 63, member A FAM63A -1,014298 -1,6389776 -1,7229424 -1,5052146 family with sequence similarity 65, member A FAM72D|FAM72FAM65A -1,1450789 1,09109 1,3066189 1,5237463 family with sequence similarity 72, member D | family with sequence similarity 72, member A | family with A|FAM72B|FAM7 sequence similarity 72, member B | family with sequence similarity 72, member C FAM72D|FAM722C 1,0317814 -1,6074086 1,1687285 1,7445328 family with sequence similarity 72, member D | family with sequence similarity 72, member A | family with A|FAM72B|FAM7 sequence similarity 72, member B | family with sequence similarity 72, member C FAM72D|FAM722C 1,0383698 -1,6300557 1,1716874 1,78385 family with sequence similarity 72, member D | family with sequence similarity 72, member A | family with A|FAM72B|FAM7 sequence similarity 72, member B | family with sequence similarity 72, member C FAM72D|FAM722C 1,0373538 -1,6438478 1,1647966 1,7441177 family with sequence similarity 72, member D | family with sequence similarity 72, member A | family with A|FAM72B|FAM7 sequence similarity 72, member B | family with sequence similarity 72, member C 2C -1,0179309 -1,7466496 1,4919552 1,9151813 family with sequence similarity 83, member A FAM83A -1,2263134 2,0701401 1,5723284 1,7167833 family with sequence similarity 83, member D FAM83D -1,1144339 -1,5372256 -1,1356065 1,114712 family with sequence similarity 83, member F FAM83F 1,2176878 -1,8126003 -1,282708 -1,0808507 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 family with sequence similarity 84, member A FAM84A -1,3017842 -1,7187477 -2,3396282 -2,1436532 family with sequence similarity 84, member B FAM84B 1,515977 1,0387447 1,1333014 1,1787533 family with sequence similarity 86, member A pseudogene FAM86B1|ALG1|FLJ10661 -1,5121273 -1,3313998 -1,3826307 -1,1846161 family with sequence similarity 86, member B1 | asparagine-linked glycosylation 1, beta-1,4- LOC645332|LOC mannosyltransferase homolog (S. cerevisiae) | family with sequence similarity 86, member A pseudogene 653113 1,3405994 1,5096503 1,1245232 1,0337777 FAM86B1|FAM86 family with sequence similarity 86, member B1 | family with sequence similarity 86, member C C 1,3281707 1,6927265 -1,0189743 1,2838936 family with sequence similarity 89, member A FAM89A 1,319266 1,257497 1,5536433 1,3906556 family with sequence similarity 99, member A FAM99A -1,1531862 1,1514076 -1,2982389 -1,517654

Fanconi anemia, complementation group E FANCE -1,1139493 -1,5699563 -1,0762379 1,1284363 farnesyl diphosphate synthase FDPS 1,0125854 1,1677864 2,5775862 3,1527514 farnesyl diphosphate synthase | chromosome 1 open reading frame 104 FDPS|C1orf104 -1,0042658 -1,4706619 -1,6771839 -1,3545913 farnesyl-diphosphate farnesyltransferase 1 FDFT1 1,0855917 -1,0642803 2,066185 2,2422655 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) FSCN1 -1,2836275 1,5307399 1,9306418 2,5189023

FAST kinase domains 1 FASTKD1 1,3068241 -1,5499362 -1,1641765 -1,2151855

FAT tumor suppressor homolog 2 (Drosophila) FAT2 -1,0278454 -1,7411785 -1,3065326 -1,2347242 fatty acid 2-hydroxylase FA2H -1,2636374 -1,1689217 -1,2363744 -1,5969094 fatty acid binding protein 4, adipocyte FABP4 1,2662053 -1,6791595 1,4326051 1,9980793 fatty acid desaturase 1 FADS1 -1,1576527 -1,0281552 1,8187143 2,0055711 fatty acid desaturase 3 FADS3 -1,1899282 -1,1715336 1,8750263 1,4318558 fatty acid synthase FASN 1,0398432 -1,2355438 1,2523024 1,6999153

FBJ murine osteosarcoma viral oncogene homolog FOS 1,248452 1,9569346 2,7499583 2,8384092

Fc fragment of IgG, low affinity IIa, receptor (CD32) FCGR2A -1,0852405 1,2164955 1,3430768 2,238509 feline leukemia virus subgroup C cellular receptor 1 FLVCR1 1,4056567 1,1100658 1,5225143 1,4187286 fer (fps/fes related) tyrosine kinase FER -1,027717 -1,5544518 -1,0283048 1,2040002

FERM domain containing 4B FRMD4B 1,58705 1,7949048 1,2383608 1,0875001

FERM domain containing 5 FRMD5 1,0832201 -1,5643172 -1,3919368 -1,3759743 fermitin family member 1 FERMT1 1,0819187 1,6284848 1,5288893 2,6907654 ferric-chelate reductase 1 FRRS1 -1,1116769 -2,2333217 -1,3382133 -1,2003542 fibrinogen gamma chain FGG -1,0092808 1,186584 2,176056 2,6183467 fibroblast activation protein, alpha FAP 1,0927931 -1,1391523 1,1557618 1,621432 fibroblast growth factor 1 (acidic) FGF1 1,1742514 -1,2872657 -1,3837292 -1,9585264 fibroblast growth factor 11 FGF11 -1,9008564 -1,0323719 -1,0713512 -1,0559512 fibroblast growth factor binding protein 1 FGFBP1 -1,1225239 -1,5116445 1,0913941 1,3511813 fibroblast growth factor receptor 2 FGFR2 1,0731356 -2,0815141 -1,9336828 -1,9942118 fibronectin leucine rich transmembrane protein 3 FLRT3 1,7496669 4,1675563 7,5708184 7,2472696 fibronectin type III and ankyrin repeat domains 1 FANK1 -1,192768 -1,9027617 -1,4268811 -1,440305 fibronectin type III domain containing 3B FNDC3B 1,0658052 1,5537297 1,5309777 1,4543089 fidgetin FIGN 1,2565261 1,2419891 1,4954175 1,7705239 filaggrin FLG -1,9434719 -3,1591978 -3,047428 -3,1434057 filamin A, alpha FLNA -1,0933025 -1,1071931 1,6762755 1,5056957 filamin B, beta FLNB 1,0158913 1,948454 2,1953964 2,575065 flavin containing monooxygenase 5 FMO5 1,0935901 -1,293238 -1,5967811 -1,4767582 flotillin 1 FLOT1 1,0771134 1,5990485 1,4479663 1,7676681 flotillin 1 FLOT1 1,0755332 1,5970446 1,4463496 1,7691662 flotillin 1 FLOT1 1,07807 1,5949767 1,4458125 1,7700775 flotillin 2 FLOT2 1,3722324 1,7188147 1,8696932 1,8888063 folate hydrolase (prostate-specific membrane antigen) 1 FOLH1 -1,6284482 1,3432465 -1,0537965 -1,3128335 folliculin interacting protein 1 FNIP1 -1,1228831 -1,7363694 -1,0247389 1,0125773 folliculin interacting protein 2 FNIP2 1,1220584 -1,227607 1,5032368 2,2406557 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 follistatin FST 1,149007 3,554117 4,020562 4,051177 folylpolyglutamate synthase FPGS 1,0782382 -1,0214764 1,2240481 1,5895467 forkhead box A1 FOXA1 1,1353769 -1,4873753 -1,7863421 -2,2839253 forkhead box N1 FOXN1 -1,810169 -5,076474 -1,7247399 -2,1078222 forkhead box N3 FOXN3 -1,0304939 -1,8097496 -1,4628118 -1,2910565 forkhead box O3B pseudogene | forkhead box O3 FOXO3B -1,2253426 -1,6586637 -1,4303252 -1,2333529 forkhead box O4 FOXO4 1,2252612 -1,665431 -1,225522 -1,1825924 forkhead box Q1 FOXQ1 -1,3533392 -1,8005389 -1,6991065 -1,5810385 formin binding protein 1-like FNBP1L -1,416018 -1,9341161 -1,5535187 -1,5918695 formin homology 2 domain containing 1 | solute carrier family 9 (sodium/hydrogen exchanger), member 5 FHOD1|SLC9A5 1,1103425 1,1807848 1,535897 1,7190329 formin-like 2 FMNL2 1,1940452 2,890095 3,0428264 4,487413

FOS-like antigen 1 FOSL1 1,2775226 2,2253044 1,4290295 1,9329646 four and a half LIM domains 2 FHL2 1,6361362 2,5381472 3,3495395 3,5762818 four jointed box 1 (Drosophila) FJX1 -1,0693549 1,6197035 1,0674759 1,231204 fragile X mental retardation 1 FMR1 -1,1099763 -1,7679503 -1,357755 -1,3472579 frataxin FXN 1,2671167 1,6032175 1,2126393 1,3124205 frizzled homolog 5 (Drosophila) FZD5 1,157222 -1,627752 -1,1536453 1,0060924 frizzled homolog 6 (Drosophila) FZD6 1,09664 -1,5441797 -1,6052897 -1,4217488 fructosamine 3 kinase related protein FN3KRP -1,1927018 -1,5082479 -1,2544774 1,0269096 fructose-1,6-bisphosphatase 1 FBP1 1,1312206 -1,5095391 -3,969634 -4,3796988 fucosyltransferase 2 (secretor status included) FUT2 1,5867416 1,9875598 1,9908518 2,1963792 furin (paired basic amino acid cleaving enzyme) FURIN 1,0307207 1,2978433 1,252974 1,6966989

FYN binding protein FYB 1,1614301 -1,6183523 -1,4009073 -1,1152542 fyn-related kinase FRK 1,0695033 -1,8793248 -1,4150767 -1,6959846

FYVE, RhoGEF and PH domain containing 3 FGD3 1,0418553 1,0143164 1,6323805 1,2139755

G elongation factor, mitochondrial 1 GFM1 1,7354032 1,1210111 1,0627167 1,0146766

G patch domain containing 4 GPATCH4 1,4526385 1,6935486 1,2431124 1,3528485

G protein-coupled receptor 1 GPR1 1,0168773 -1,6110313 -1,0306615 -1,1668048

G protein-coupled receptor 109A GPR109A 1,2467387 -1,0589973 -1,6859726 -1,4807377

G protein-coupled receptor 109B GPR109B 1,7865678 -1,0315826 -1,4744748 -1,2266446

G protein-coupled receptor 110 GPR110 1,0000304 -1,1305373 -1,8541397 -2,7270226

G protein-coupled receptor 116 GPR116 -1,1137288 1,5587205 1,1249641 -1,2242339

G protein-coupled receptor 125 | dispatched homolog 2 (Drosophila) GPR125|DISP2 1,3128674 -1,8517034 -1,1793736 -1,0662639

G protein-coupled receptor 126 GPR126 1,3314245 1,4873856 1,5072054 1,5547796

G protein-coupled receptor 128 GPR128 1,3849376 1,7536883 2,1384695 1,0375663

G protein-coupled receptor 141 GPR141 1,1549053 1,5406482 -1,0209519 -1,0966135

G protein-coupled receptor 150 GPR150 -1,0581261 1,5239894 -1,0656816 -1,2010796

G protein-coupled receptor 155 GPR155 1,7403028 1,1319278 1,3523823 1,4205322

G protein-coupled receptor 161 GPR161 -1,0066686 -1,3207266 -1,1371074 -1,6141407

G protein-coupled receptor 21 GPR21 -1,1572503 -1,9971583 -1,4833078 -1,1243519

G protein-coupled receptor 37 (endothelin receptor type B-like) GPR37 1,4527495 1,6785659 3,7302713 6,4131584

G protein-coupled receptor 37 like 1 GPR37L1 1,0369235 -1,2389269 -1,4335747 -1,5571145

G protein-coupled receptor 39 | LY6/PLAUR domain containing 1 GPR39|LYPD1 1,2801833 -1,5113128 -1,681571 -1,2002169 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31

G protein-coupled receptor 52 GPR52 1,1061177 -2,2644932 -1,4827305 -1,4353228

G protein-coupled receptor 56 GPR56 -1,0631615 -1,6321771 -1,6098304 -1,420475

G protein-coupled receptor associated sorting protein 1 GPRASP1 -1,0428311 -1,5367582 -1,3105505 -1,1353682

G protein-coupled receptor kinase interacting ArfGAP 1 GIT1 -1,1290668 -1,5765717 -1,4058658 -1,2370558

G protein-coupled receptor, family C, group 5, member A GPRC5A -1,0560479 2,8032115 -1,0195093 -1,3132823

G-protein signaling modulator 2 | chloride channel CLIC-like 1 GPSM2|CLCC1 -1,0399016 -2,1956184 -1,4573369 -1,4481229

G-rich RNA sequence binding factor 1 GRSF1 1,0946468 1,0458454 1,2199712 1,5839466

GA binding protein transcription factor, beta subunit 1 GABPB1 1,1769099 1,2964234 1,1371161 1,5252392

GA binding protein transcription factor, beta subunit 2 GABPB2 1,048544 -1,3189734 -1,5679308 -1,2795662 galactose mutarotase (aldose 1-epimerase) GALM 1,0717391 -1,7409115 -1,2070228 -1,413721 galactosidase, alpha GLA 1,1848898 1,129614 1,7007269 1,6288424 galectin-related protein HSPC159 -1,4992272 -1,76635 -1,0924327 -1,361826 gamma-aminobutyric acid (GABA) A receptor, pi GABRP 1,009835 -1,2052655 -2,1183844 -3,437883 gap junction protein, alpha 1, 43kDa GJA1 1,0043963 -1,651132 -1,1023324 1,0815283 gap junction protein, beta 2, 26kDa GJB2 -1,0618137 3,7137718 4,297741 4,7628036 gap junction protein, beta 3, 31kDa GJB3 -1,2712116 -1,1208463 1,3041489 1,5267766 gap junction protein, beta 6, 30kDa GJB6 -1,976803 1,226161 1,9795667 2,2277954 gap junction protein, delta 4, 40.1kDa GJD4 -1,0611653 1,1736187 -1,030839 -1,5639724 gasdermin A GSDMA -1,035041 1,4880573 1,4492317 1,8736165 gasdermin B GSDMB 1,0878769 -1,1017175 -2,2186735 -2,0674317 gasdermin C GSDMC 2,3497584 3,118658 4,142747 5,552718

GATA binding protein 3 GATA3 -1,2776324 -1,946698 -1,7408586 -1,8299996

GATS protein-like 1 | GATS protein-like 2 | GATS, stromal antigen 3 opposite strand GATSL1|GATSL2 1,113067 -1,6524231 -1,2023399 -1,3050358

GATS protein-like 1 | GATS protein-like 2 | GATS, stromal antigen 3 opposite strand GATSL1|GATSL2 1,1144589 -1,6616751 -1,2034256 -1,3050109

GDP-mannose 4,6-dehydratase GMDS 1,381743 1,9547296 1,7249874 1,4329286 gelsolin GSN -1,0769781 -1,3982604 -1,5770855 -1,534385 gem (nuclear organelle) associated protein 7 GEMIN7 1,104172 -1,525935 -1,0810119 1,0425495

Gen homolog 1, endonuclease (Drosophila) GTF2H2|GTF2HGEN1 1,1899157 -1,8738604 -1,4936609 -1,2845858 general transcription factor IIH, polypeptide 2, 44kDa | general transcription factor IIH, polypeptide 2C | 2C|GTF2H2B|GT general transcription factor IIH, polypeptide 2B | general transcription factor IIH, polypeptide 2D F2H2DGTF2H2|GTF2H 1,6273614 1,2045777 1,2753279 1,220696 general transcription factor IIH, polypeptide 2, 44kDa | general transcription factor IIH, polypeptide 2C | 2C|GTF2H2B|GT general transcription factor IIH, polypeptide 2B | general transcription factor IIH, polypeptide 2D F2H2DGTF2H2|GTF2H 1,6177485 1,2095056 1,2735486 1,2258734 general transcription factor IIH, polypeptide 2, 44kDa | general transcription factor IIH, polypeptide 2C | 2C|GTF2H2B|GT general transcription factor IIH, polypeptide 2B | general transcription factor IIH, polypeptide 2D F2H2DGTF2H2|GTF2H 1,5981207 1,1832883 1,3011037 1,2367827 general transcription factor IIH, polypeptide 2, 44kDa | general transcription factor IIH, polypeptide 2C | 2C|GTF2H2D|GT general transcription factor IIH, polypeptide 2D | general transcription factor IIH, polypeptide 2B F2H2B 1,626829 1,2599399 1,3796142 1,2719451 general transcription factor IIH, polypeptide 2D | general transcription factor IIH, polypeptide 2, 44kDa | GTF2H2D|GTF2 general transcription factor IIH, polypeptide 2C | general transcription factor IIH, polypeptide 2B H2C|GTF2H2B 1,534838 1,188545 1,2603077 1,2186421 general transcription factor IIi GTF2I 1,032549 -1,7598594 -1,3654 -1,3166618 general transcription factor IIIC, polypeptide 6, alpha 35kDa GTF3C6 1,2409486 1,7020764 1,611452 1,1867727 gigaxonin GAN -1,3167915 -1,755221 -1,308813 -1,2503033

GINS complex subunit 3 (Psf3 homolog) GINS3 -1,1709429 -1,528855 1,1390668 1,1784841 glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase GNE 1,282887 1,5167283 2,3332202 2,273415 glucosamine-6-phosphate deaminase 1 GNPDA1 1,1560224 -1,0397751 1,6105361 1,6404648 glucosaminyl (N-acetyl) transferase 1, core 2 GCNT1 1,6815438 1,8657855 1,425059 1,3198531 glucosaminyl (N-acetyl) transferase 3, mucin type GCNT3 1,1053067 1,8338214 1,7694885 1,5741177 glucose-6-phosphate dehydrogenase G6PD 1,1382995 -1,0824753 1,3486551 1,5559961 glucose-6-phosphate isomerase GPI -2,0847735 -1,9218075 -1,1878864 -1,3050324 glutamate receptor interacting protein 1 GRIP1 1,0576911 -1,8586875 -1,5830866 -1,346603 glutamate-ammonia ligase GLUL -1,0680106 -1,7533985 -1,1467415 -1,2051842 glutamate-ammonia ligase GLUL -1,1362336 -1,8876255 -1,1788718 -1,242693 glutamate-cysteine ligase, catalytic subunit GCLC 1,0094069 -2,1448162 -1,4711952 -1,3400351 glutamate-cysteine ligase, modifier subunit GCLM 1,313465 1,2488544 1,5480286 2,1159003 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 glutaredoxin (thioltransferase) GLRX 1,0550013 -1,543351 1,2028455 1,3792039 glutathione S-transferase mu 1 GSTM1 -1,0537512 1,0553043 -1,4533815 -1,5259981 glutathione synthetase GSS 1,1520563 1,2240644 1,4743651 1,5486673 glycerol kinase GK 1,3867171 1,0290354 1,012246 1,8888282 glycerol kinase | glycerol kinase 3 pseudogene GK|GK3P 1,3004111 1,1525198 1,1014466 1,8162873 glycerol-3-phosphate dehydrogenase 1-like GPD1L 1,3199002 -2,392671 -1,3136257 -1,6225481 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) GPD2 1,501147 2,3557243 2,0957294 2,4290862 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) GCSH|LOC7290GPCPD1 1,1147054 1,7074095 1,5434234 2,1463435 glycine cleavage system protein H (aminomethyl carrier) | glycine cleavage system H pseudogene | glycine 80|LOC10032910 cleavage system protein H pseudogene GCSH|LOC72908|LOC100329109 1,1165406 1,0971273 1,2956965 1,5530114 glycine cleavage system protein H (aminomethyl carrier) | glycine cleavage system H pseudogene | glycine 80|LOC10032910 cleavage system protein H pseudogene 8|LOC100329109 1,1318115 1,1406428 1,31883 1,5297244 glycine dehydrogenase (decarboxylating) GLDC -1,5694323 1,0286766 1,0828614 -1,0490159 glycine-N-acyltransferase-like 2 GLYATL2 1,1194472 -1,2856869 -3,3221664 -4,5446053 glycogenin 1 GYG1 1,3531133 1,5003563 1,1738677 1,1430997 glycolipid transfer protein GLTP -1,3063875 -1,8904289 -1,3029267 -1,4382323 glycoprotein (transmembrane) nmb GPNMB 1,0488987 -1,4959761 -1,5697964 -1,0847317 glycoprotein VI (platelet) GP6 -1,2133778 1,0894867 -1,661808 -1,3134125 glycyl-tRNA synthetase GARS 1,0069504 1,393746 1,3904158 1,9710962 glypican 6 GPC6 -1,0125386 1,1508894 2,2861147 3,4405053 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 GOLGA6L9|GOLGGA2 1,0412457 -1,9738226 -1,5740184 -1,8533849 golgin A6 family-like 9 | golgin A6 family-like 10 | golgin A6 family-like 5 (pseudogene) | golgin A6 family-like 3 | GA6L10|GOLGA golgin A6 family-like 4 6L5|GOLGA6L3|GOLGA6A|GOL -1,2898982 -1,5102162 -1,4182503 -1,3673537 GA6B|LOC64575 golgin A6 family, member A | golgin A6 family, member B | golgi autoantigen, golgin subfamily a, 6 pseudogene 2 -1,0597644 -1,5116565 1,1238176 1,2167823

GRAM domain containing 1C GRAMD1C 1,0988177 -2,254343 -1,7670443 -1,6968739 granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) GZMB -1,1288172 1,4595689 12,260564 16,263554

GRB2-associated binding protein 1 GAB1 1,0108211 -1,5105886 1,0056226 -1,0261102 GCOM1|GRINL1 GRINL1A complex locus | glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A A -1,4220928 -1,0853965 -1,0817438 -1,5173901 growth arrest and DNA-damage-inducible, beta GADD45B 1,760923 1,8636838 1,3728988 1,5128766 growth arrest-specific 2 like 3 GAS2L3 1,0925801 -1,6482226 1,364569 1,6282346 growth factor receptor-bound protein 10 GRB10 -1,0881526 -1,0341218 1,457877 1,8289468 growth factor receptor-bound protein 7 GRB7 1,2314401 1,2450635 1,8047571 1,965122

GTF2I repeat domain containing 1 GTF2IRD1 -1,2986617 -2,208495 -1,0096318 1,0261896

GTF2I repeat domain containing 2B | GTF2I repeat domain containing 2 GTF2IRD2B 1,0469092 -1,5163383 -1,4073215 -1,3659141

GTP-binding protein 8 (putative) GTPBP8 1,0009233 -1,5490911 -1,5680463 -1,2692943 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) GNA15 1,1504072 1,7590535 1,634278 2,146701 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O GNG10|DNAJC2GNAO1 -1,1345272 -1,446309 -1,5005766 -1,3557312 guanine nucleotide binding protein (G protein), gamma 10 | DNAJC25-GNG10 readthrough | guanine 5- nucleotide binding protein (G protein), gamma 10 pseudogene GNG10|LOC100 1,2196447 2,031886 1,4164131 1,2858169 guanine nucleotide binding protein (G protein), gamma 11 GNG11 1,1120563 1,0519838 1,1700151 1,5031593 guanine nucleotide binding protein (G protein), gamma 4 GNG4 -1,5137955 1,0773213 2,4778874 1,4567114 guanine nucleotide binding protein (G protein), gamma 5 GNG5 -1,0256463 1,2871792 1,32354 1,6618377 guanine nucleotide binding protein-like 3 (nucleolar) GNL3 1,5167443 1,8383182 1,2766948 1,3101573 guanylate binding protein 1, interferon-inducible, 67kDa | guanylate binding protein 3 GBP1|GBP3 1,6190875 1,5826963 1,2038171 1,3678713 guanylate binding protein 2, interferon-inducible GBP2 2,1374307 1,6685655 1,801552 1,9608206 guanylate binding protein 3 GBP3 1,6601337 1,46521 -1,0252156 1,1316742 guanylate binding protein 4 GBP4 1,9286091 1,4381107 -1,8490033 -1,4018077 guanylate binding protein family, member 6 GBP6 -1,219128 -3,169197 -1,2481397 -1,4623642

GULP, engulfment adaptor PTB domain containing 1 GULP1 1,0378469 -3,9512963 -1,8461766 -1,1288817

H19, imprinted maternally expressed transcript (non-protein coding) | microRNA 675 H19|MIR675 -1,1654912 -1,8596387 -3,0591676 -4,7861333

H2A histone family, member Z H2AFZ 1,1401098 -1,0193348 1,0459933 1,5573646

H3 histone, family 3C H3F3C 1,0630603 1,538477 1,5391158 1,7359345 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 hairless homolog (mouse) HR -1,0963877 -1,5958858 -1,2080374 -1,1387258 haptoglobin HP 1,1010877 3,0609446 26,515877 33,923897 haptoglobin-related protein HPR -1,243045 1,4637158 3,2326665 4,3498306

HAUS augmin-like complex, subunit 3 | polymerase (DNA directed) nu HAUS3|POLN 1,0450313 -1,5940155 -1,1275669 1,1263694

HAUS augmin-like complex, subunit 6 HAUS6 1,9130688 -1,0774851 1,3916148 1,0639573 heat shock 105kDa/110kDa protein 1 HSPH1 2,0227451 2,071376 1,9423238 2,2301722 heat shock 27kDa protein 1 HSPB1 -1,0081059 -1,2085006 -1,3222729 -1,5551096 heat shock 60kDa protein 1 (chaperonin) HSPD1 1,0417647 1,7797546 1,572634 1,2421608 heat shock 70kD protein 12B HSPA12B -1,1900525 1,5002642 -1,0010923 -1,2567209 heat shock 70kDa protein 12A HSPA12A -1,262507 -1,6743009 -1,2017916 -1,3669817 heat shock 70kDa protein 4-like HSPA4L 1,0262316 -1,0837712 1,7363453 1,5062896 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) HSPA5 1,183872 1,546247 1,4833078 -1,0465404 heat shock 70kDa protein 6 (HSP70B') HSPA6 1,0035521 1,4038084 2,4272676 3,149453 heat shock 70kDa protein 9 (mortalin) HSPA9 1,3556483 1,5474157 1,1463792 1,3460509 heat shock protein 90kDa alpha (cytosolic), class A member 2 HSP90AA2 1,2517405 1,3627138 1,2848101 1,5325766 heat shock protein 90kDa alpha (cytosolic), class B member 3 (pseudogene) HSP90AB3P -1,0185709 1,3932209 1,4630729 1,5532881 HERC2P4|HERC hect domain and RLD 2 pseudogene 4 | hect domain and RLD 2 pseudogene 9 2P9 1,104211 -1,3253926 -1,3428177 -1,50631 hect domain and RLD 5 HERC5 1,0124484 1,1072041 1,6678619 1,552174 hect domain and RLD 6 HERC6 1,0886772 -1,303484 -1,0369167 1,912053

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 HECW2 1,023564 -1,0079724 -1,3309835 -1,9182588 helicase (DNA) B HELB 1,6083982 1,3525218 1,3143891 1,9162647 helicase with zinc finger HELZ -1,0073498 -1,5157641 -1,3302675 -1,3372477 helicase, POLQ-like HELQ -1,1077532 -1,5044512 -1,1250169 -1,0709076 hemicentin 2 HMCN2 -1,5065998 1,1020842 -1,1066388 -1,1529546 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 HS3ST1 1,1913 2,3239653 1,5784857 2,1202588 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 HS3ST6 -1,2757474 -1,0292538 -1,2978511 -1,5672277 heparan sulfate 2-O-sulfotransferase 1 HS2ST1 -1,0299641 1,110537 1,7340329 1,9366199 HSPG2|LDLRAD heparan sulfate proteoglycan 2 | low density lipoprotein receptor class A domain containing 2 2 -1,0725838 -1,246714 -1,5195432 -1,4474137 heparin-binding EGF-like growth factor HBEGF 2,8365645 3,137311 2,2570755 4,178929 hephaestin-like 1 HEPHL1 -1,0314323 1,1615626 1,5788807 2,715781 heterogeneous nuclear ribonucleoprotein A1 HNRNPA1 1,6829077 1,0363235 1,0384392 1,2162652 heterogeneous nuclear ribonucleoprotein F HNRNPF 1,377174 1,8042789 1,3353918 1,2768767 hexamethylene bis-acetamide inducible 1 HEXIM1 -1,1938361 -1,531826 -1,2236056 -1,0568112 hexokinase 2 HK2 1,136323 1,9379965 1,7349502 1,9255155

HIG1 hypoxia inducible domain family, member 1A HIGD1A 1,4483224 1,9741873 1,7571284 1,859943

HIG1 hypoxia inducible domain family, member 1A HIGD1A 1,3483181 1,8936406 1,9549253 2,2059155 high mobility group AT-hook 2 HMGA2 -1,1302254 1,0206772 1,2607881 1,5594805 high mobility group nucleosomal binding domain 3 HMGN3 1,2112198 -1,7028304 -1,4276075 -1,0758393 high-mobility group box 1 HMGB1 1,168365 -1,7480022 -1,0672053 1,2020987 high-mobility group box 2 HMGB2 -1,0236181 -1,6443712 -1,0884322 1,0107881 histamine receptor H2 HRH2 -1,1108149 1,4001065 1,818686 2,1239097 histidine triad nucleotide binding protein 3 HINT3 1,7442538 1,6053618 1,4189316 1,6433926 histocompatibility (minor) HA-1 HMHA1 1,0899463 1,5702178 -1,1709464 1,0329757 histone cluster 1, H1b HIST1H1B -1,3755273 -1,5492305 1,2415508 1,4468608 histone cluster 1, H2ae HIST1H2AE -1,3799198 -1,5667347 -1,2461994 -1,0790232 histone cluster 1, H2ag HIST1H2AG -1,1099565 -1,6820536 -1,2729132 -1,0257142 histone cluster 1, H2ai HIST1H2AI -1,2715874 -1,6222901 -1,006992 1,2180372 HIST1H2AI|HIST histone cluster 1, H2ai | histone cluster 1, H3h 1H3H -1,203086 -1,9849483 -1,2081304 1,3404164 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 histone cluster 1, H2bd HIST1H2BD 1,0442158 -1,70904 -1,5450414 -1,0469134 histone cluster 1, H2bf HIST1H2BF -1,3936096 -1,8263608 -1,4036279 1,0501975 histone cluster 1, H2bg HIST1H2BG -1,2914095 -1,8293967 -1,434857 1,0443373 histone cluster 1, H2bj HIST1H2BJ -1,1352955 -1,5868742 -1,1226627 1,0788656 histone cluster 1, H2bk HIST1H2BK 1,0791203 -1,1382995 1,3066311 1,5600961 histone cluster 1, H3b HIST1H3B -1,393535 -1,6317682 -1,0217563 1,5028831 HIST1H3D|HIST histone cluster 1, H3d | histone cluster 1, H2ad 1H2AD -1,3000652 -1,61764 -1,2104018 1,1332136 histone cluster 1, H3e HIST1H3E 1,1978356 -2,283517 -1,268702 1,0019413 histone cluster 1, H3f HIST1H3F -1,2301171 -1,5781024 1,0074078 1,3916084 histone cluster 1, H3g HIST1H3G -1,3562587 -1,8872862 1,0309207 1,4033046 histone cluster 1, H3h HIST1H3H -1,1481136 -2,0657043 -1,2751399 1,4246497 histone cluster 1, H3i HIST1H3I -1,5224932 -1,6180367 -1,4006082 1,0655854 histone cluster 1, H3j HIST1H3J -1,1215993 -1,508712 -1,1945686 -1,0031912 histone cluster 1, H4b HIST1H4B -1,2417388 -1,5307915 -1,0634321 1,1414151 histone cluster 1, H4c HIST1H4C -1,2676793 -1,6509398 -1,4196254 -1,2673048 histone cluster 1, H4d HIST1H4D -1,165361 -1,5651323 -1,1441671 -1,1666098 histone cluster 1, H4e HIST1H4E -1,223287 -1,5268602 -1,3627806 -1,088107 histone cluster 1, H4h HIST1H4H -1,3802801 -2,2351813 -1,5524987 -1,2751104 HIST1H4K|HIST1 histone cluster 1, H4k | histone cluster 1, H4j H4J -1,2436142 -1,5167363 1,0034765 1,1731037 histone cluster 1, H4l HIST1H4L -1,1651504 -1,6808348 -1,3120449 1,0627097 histone cluster 2, H2ab HIST2H2AB -1,4646416 -1,6932491 -1,2411808 1,4888095 HIST2H2AC|BOL histone cluster 2, H2ac | bolA homolog 1 (E. coli) A1 -1,3740296 -1,2074345 -1,5365002 1,2277085 HIST2H2BF|HIS histone cluster 2, H2bf | histone cluster 2, H2ba HIST2H2BF|HIST2H2BA -1,2810557 -1,7938064 -1,3892995 -1,0465751 T2H2BA|HIST2H histone cluster 2, H2bf | histone cluster 2, H2ba | histone cluster 2, H2be 2BE -1,3012784 -1,6843473 -1,356629 -1,0594279 HIST2H4A|HIST2 histone cluster 2, H4a | histone cluster 2, H4b H4B -1,5251454 -2,0519056 -1,34213 -1,2902733 HIST2H4A|HIST2 histone cluster 2, H4a | histone cluster 2, H4b H4B -1,5274065 -2,048141 -1,3465021 -1,2908219 histone cluster 3, H2a HIST3H2A -1,2654133 -1,9105362 -1,3519073 -1,0597161 histone cluster 4, H4 HIST4H4 -1,0939234 -1,7587302 -1,3681439 -1,0356354

HLA complex group 27 HCG27 1,0364102 -1,2175105 -1,1916454 -1,5690671

HLA complex group 4 HCG4 -1,1266243 1,1276402 -1,5727271 -1,218529

HLA complex P5 HCP5 1,4154977 -1,0889943 -1,6414758 -1,5424148 homeobox A2 HOXA2 1,8057286 1,1485099 -1,1693243 -1,4007976 homeobox D10 HOXD10 -1,1147367 -1,9559944 -1,3605689 -1,3615298 homeodomain interacting protein kinase 3 HIPK3 1,8739322 1,4537543 1,2182587 1,4879874 homer homolog 1 (Drosophila) HOMER1 1,3436736 1,3298926 1,6936796 2,0038033 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 HERPUD1 -1,5016403 -1,2771046 -1,285093 -1,2559261

HRAS-like suppressor 2 HRASLS2 1,3803686 1,9171414 1,8529303 2,3334677

HSPB (heat shock 27kDa) associated protein 1 HSPBAP1 1,6246872 -1,290038 -1,0780942 -1,0066679 human immunodeficiency virus type I enhancer binding protein 1 HIVEP1 1,2857795 1,225849 1,3457714 1,6075717 human immunodeficiency virus type I enhancer binding protein 2 HIVEP2 1,3003187 2,0646353 1,5071894 1,5783997 hyaluronan and proteoglycan link protein 3 HAPLN3 1,4647365 1,4294707 1,7092022 1,5405056 hyaluronan synthase 2 HAS2 -1,0335741 1,2116466 1,2890465 1,7382368 hyaluronan synthase 3 | CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) HAS3|CHTF8 1,0399442 1,3049212 1,5396724 2,5915582 hyaluronan-mediated motility receptor (RHAMM) HMMR -1,0155469 -1,8572788 1,1124657 1,2774355 hydroxyprostaglandin dehydrogenase 15-(NAD) HPGD 1,6830552 -1,5296414 -2,4521794 -3,2859478 hydroxysteroid (11-beta) dehydrogenase 2 HSD11B2 -1,2189205 -1,516627 -1,4170125 -1,6981099 hydroxysteroid (17-beta) dehydrogenase 12 HSD17B12 -1,0312427 1,1756545 1,5013008 1,3047063 hydroxysteroid (17-beta) dehydrogenase 2 HSD17B2 1,0919338 1,6919289 4,5015864 6,650557 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 HSD17B7|HSD1 hydroxysteroid (17-beta) dehydrogenase 7 | hydroxysteroid (17-beta) dehydrogenase 7 pseudogene 2 7B7P2 1,0748675 -1,1523736 2,299319 3,481832 hydroxysteroid (17-beta) dehydrogenase 7 pseudogene 2 HSD17B7P2 1,0944425 -1,1623737 1,5924946 3,2186618 LOC100128252|L hypothetical LOC100128252 | hypothetical LOC100288114 OC100288114 -1,0261967 -1,0694015 -1,2729625 1,5239471 hypothetical LOC143153 FLJ31958 -1,6548717 1,0279765 -1,0028446 1,0343751 LOC339524|HS2 hypothetical LOC339524 | heparan sulfate 2-O-sulfotransferase 1 ST1 1,0235379 1,0652379 1,8860016 1,30761 hypothetical LOC386627 FLJ38109 1,3834361 -1,0353181 1,2951814 1,5509253 LOC388152|LOC 80154|LOC72784 hypothetical LOC388152 | hypothetical LOC80154 | golgin A2 pseudogene | hypothetical LOC642423 | 9|LOC642423|LO hypothetical LOC727751 C727751 -1,2934364 -1,7561326 -1,6337953 -1,8011281 LOC388692|LOC hypothetical LOC388692 | UPF0627 protein ENSP00000358171-like 644634 1,0793543 1,5358884 1,1983052 1,5098499 LOC389634|LOC hypothetical LOC389634 | hypothetical LOC441268 441268 -1,3741977 1,3101451 -1,012726 -1,6361502 LOC400590|LOC hypothetical LOC400590 | hypothetical protein LOC100507904 100507904 -1,0678884 -1,560679 -1,6535556 -1,2254075 hypothetical LOC401105 FLJ42393 1,5427624 1,1078157 1,0699786 1,2048215 MGC57346|CRH hypothetical LOC401884 | corticotropin releasing hormone receptor 1 R1 -1,3317457 -1,71835 -1,586539 -2,0694587 hypothetical LOC441058 MGC39584 -1,3899953 1,1814095 1,5653987 -1,050311 hypothetical LOC641737 FLJ44124 -1,3391964 -1,5332054 -1,4842265 -1,4886097 hypothetical LOC641928 FLJ16734 1,3382695 -1,4533623 -1,3077639 -1,5243678 hypothetical LOC645524 FLJ36840 -1,0315496 -1,5077355 -1,3545492 -1,0537822 hypothetical LOC649446 FLJ35776 1,516815 1,0062753 1,009165 1,1685933 hypothetical LOC651430 FLJ38576 -1,140838 1,0328815 -1,0184764 -1,5141287 LOC80154|LOC7 27849|LOC38815 hypothetical LOC80154 | golgin A2 pseudogene | hypothetical LOC388152 | hypothetical LOC727751 | 2|LOC727751|LO hypothetical LOC642423 C642423 -1,3724066 -1,7483858 -1,6169708 -1,8692619 LOC80154|LOC7 27849|LOC38815 hypothetical LOC80154 | golgin A2 pseudogene | hypothetical LOC388152 | hypothetical LOC727751 | 2|LOC727751|LO hypothetical LOC642423 C642423 -1,3631716 -1,748906 -1,608133 -1,8899117 LOC80154|LOC7 27849|LOC38815 hypothetical LOC80154 | golgin A2 pseudogene | hypothetical LOC388152 | hypothetical LOC727751 | 2|LOC727751|LO hypothetical LOC642423 C642423 -1,3518353 -1,7741059 -1,661148 -1,8923368 LOC80154|LOC6 hypothetical LOC80154 | hypothetical LOC642423 42423 -1,4664075 -1,5630525 -1,5568593 -1,8487216 LOC80154|LOC7 27751|LOC72784 9|LOC388152|LO hypothetical LOC80154 | hypothetical LOC727751 | golgin A2 pseudogene | hypothetical LOC388152 | C642423|LOC44 hypothetical LOC642423 | chondroitin sulfate proteoglycan 4 pseudogene 0297 -1,4092731 -1,762409 -1,6781847 -2,038729 hypothetical locus LOC388666 FLJ36116 -1,0888039 -1,1923329 1,3370982 1,500771 hypothetical protein LOC644975 FLJ30064 -1,018608 -1,80809 -1,4282428 -1,1084007 hypoxanthine phosphoribosyltransferase 1 HPRT1 1,0244843 1,9510536 2,5342293 2,1300173 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) HIF1A 1,6715827 3,158845 3,7164586 4,444686 hypoxia up-regulated 1 HYOU1 1,4920834 1,3799571 1,6435236 1,2116746 iduronate 2-sulfatase IDS -1,0106902 -1,6423159 -1,8250635 -2,1206758 iduronate 2-sulfatase IDS -1,1123966 -1,2955989 -1,5462123 -1,4442277

IGF-like family member 4 IGFL4 1,2938392 -3,1290326 -1,2242957 -1,1179109

IgLON family member 5 IGLON5 -1,1424557 1,5292487 -1,0299555 -1,1563835

IKAROS family zinc finger 2 (Helios) IKZF2 1,0813982 -1,4125599 -1,525577 -2,2435212 immediate early response 3 IER3 1,2876447 1,609391 -1,0665946 1,4131408 immediate early response 3 IER3 1,288216 1,60827 -1,0691648 1,4171108 immunoglobulin (CD79A) binding protein 1 IGBP1 1,0546889 -1,516226 -1,257177 1,1822399 immunoglobulin heavy constant delta | immunoglobulin heavy constant gamma 1 (G1m marker) IGHD|IGHG1 -1,1435089 1,0739123 1,2128266 -1,5581894 immunoglobulin heavy variable 4-59 | immunoglobulin heavy constant alpha 2 (A2m marker) | immunoglobulin IGHV4- heavy constant gamma 1 (G1m marker) 59|IGHA2|IGHG1 -1,1003205 1,9391633 1,049082 -1,0202806 immunoglobulin superfamily, member 3 IGSF3 -1,1919656 -1,9600663 -1,2556298 -1,3241596 immunoglobulin superfamily, member 9 IGSF9 -1,2535473 -1,615451 -1,3628805 -1,4776323 immunoglobulin-like and fibronectin type III domain containing 1 IGFN1 -1,0531117 1,2033501 1,6624596 2,9581592 importin 4 IPO4 1,1000026 1,6864597 1,3099477 1,3552415 importin 7 IPO7 1,3315926 1,2848746 1,1533449 1,6340425 indoleamine 2,3-dioxygenase 1 IDO1 1,2550907 2,0636768 1,1973673 1,0830991 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 inhibin, beta A INHBA 1,7360389 1,734378 1,3934623 1,2133754 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein ID2 -1,8625606 -1,6886148 -1,7602853 -1,3345834 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein ID3 -1,4929117 -2,3614557 -3,2779098 -2,5034041 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon IKBKE -1,153842 -1,3209615 -1,5410745 -1,8051383

INO80 complex subunit C INO80C 1,3634784 1,1233667 1,3343523 1,5732247 inositol 1,4,5-triphosphate receptor interacting protein ITPRIP 1,2234035 1,2433145 1,2877179 1,6818678 inositol 1,4,5-trisphosphate 3-kinase C ITPKC 1,8540117 1,1754704 1,1305056 1,1638538 inositol polyphosphate-1-phosphatase INPP1 2,1361 1,9953517 1,4453031 1,481307 inositol polyphosphate-4-phosphatase, type II, 105kDa INPP4B -1,2731977 -1,4789451 -1,4640608 -1,5714287 inositol-3-phosphate synthase 1 ISYNA1 -1,1350565 -1,9829575 -2,2391593 -2,133113 insulin induced gene 1 INSIG1 -1,4288443 -2,4229832 1,6288337 1,7466854 insulin induced gene 2 INSIG2 -1,226928 -1,762681 -1,3922805 -1,2554708 insulin receptor substrate 1 IRS1 1,1849858 1,6079751 1,7916561 1,8541286 insulin-like growth factor binding protein 3 IGFBP3 -1,850355 -1,4821631 -1,1390386 -1,0535517 insulin-like growth factor binding protein 7 IGFBP7 -1,0647721 1,1897379 2,3974226 2,4549024 integral membrane protein 2C ITM2C 1,0321655 1,0363045 1,4624223 1,6597869 integrator complex subunit 10 INTS10 1,747353 1,2536666 1,2627481 1,3344017 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) ITGA3 1,2132167 1,4392481 1,7873179 2,1187592 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) ITGA5 -1,3731025 1,3590899 2,6995826 3,7956274 integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) ITGAV 1,092302 -1,033115 1,5455143 1,4987881 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) ITGB3 -1,0407623 5,246324 19,880018 20,758028 integrin, beta 4 ITGB4 -1,1871791 1,0103254 1,4700471 1,8316358 integrin, beta 6 ITGB6 1,3623067 3,2898448 2,34999 2,7524626 integrin, beta 8 ITGB8 -1,0358291 -1,5096972 -1,2083576 -1,1601785 intercellular adhesion molecule 1 ICAM1 1,2099714 2,4871676 2,0462432 2,9108288 interferon gamma receptor 1 IFNGR1 1,1988777 1,7703664 1,8874346 1,8929611 interferon induced transmembrane protein 1 (9-27) IFITM1 1,1216123 2,0110846 2,4927423 2,8268347 interferon induced transmembrane protein 2 (1-8D) IFITM2 1,1335748 1,7211671 1,8821456 1,7185647 interferon induced transmembrane protein 3 (1-8U) IFITM3 1,1018887 2,5459526 2,5013669 2,737965 interferon induced with helicase C domain 1 IFIH1 1,3747165 1,0523521 1,212328 1,6307687 interferon regulatory factor 1 IRF1 3,019612 1,182161 -1,0149174 1,287004 interferon-induced protein 35 IFI35 1,4055727 1,5804491 1,3999741 1,8680359 interferon-induced protein 44 IFI44 1,2877886 -2,0592453 -1,8176043 1,6437435 interferon-induced protein 44-like IFI44L -1,1321782 -1,0385833 1,2880713 3,725328 interferon-induced protein with tetratricopeptide repeats 1 IFIT1 1,2490146 -1,5747577 1,8801394 3,8010294 interferon-induced protein with tetratricopeptide repeats 2 IFIT2 2,7729301 4,515578 6,7366185 10,263798 interferon-induced protein with tetratricopeptide repeats 3 IFIT3 2,3960361 1,8526303 2,674498 4,6854143 interferon-induced protein with tetratricopeptide repeats 5 IFIT5 1,2035419 1,1673661 1,1418879 1,6345779 interferon-related developmental regulator 1 IFRD1 -1,1025317 -1,213598 1,3864669 1,5906739 interferon, alpha-inducible protein 27 IFI27 -1,1810519 1,0010794 1,474819 2,47036 interferon, alpha-inducible protein 6 IFI6 1,0382401 1,1531695 1,7926964 7,285663 interferon, epsilon IFNE 1,2773625 1,3515449 1,5982717 2,3643532 interferon, gamma-inducible protein 16 IFI16 1,1885564 1,3285742 1,5282215 1,7832499 interferon, gamma-inducible protein 30 IFI30 1,566118 1,2764344 1,7431477 1,5553348 interleukin 1 family, member 9 IL1F9 1,028421 1,1953388 1,3155417 1,9687536 interleukin 1 receptor accessory protein IL1RAP 2,0072038 3,3914459 3,199449 3,4279988 interleukin 1 receptor antagonist IL1RN -1,281331 -1,1241657 1,6614269 1,7757392 interleukin 1 receptor-like 2 IL1RL2 2,1534493 1,668549 1,0285196 -1,0938834 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 interleukin 1 receptor, type I IL1R1 2,068027 2,351987 2,0177824 2,465061 interleukin 1 receptor, type II IL1R2 -1,0133883 2,1333005 3,019173 2,5395806 interleukin 1, alpha IL1A -1,2056078 6,68611 9,899024 11,952246 interleukin 1, beta IL1B -1,0847496 1,9594846 2,3299382 2,988974 interleukin 13 receptor, alpha 1 IL13RA1 1,2870567 1,7467662 2,5161746 3,2998877 interleukin 13 receptor, alpha 2 IL13RA2 1,0395871 -1,1175566 1,7683892 2,100358 interleukin 15 IL15 -1,1164442 -1,7567694 -1,5440811 -1,6317995 interleukin 17 receptor E IL17RE -1,21838 -1,3012465 -1,2326555 -1,7038393 interleukin 18 (interferon-gamma-inducing factor) IL18 -1,0751301 -1,6686803 -2,0961823 -2,3599327 interleukin 20 receptor beta IL20RB -1,104219 -1,9121528 -1,374532 -1,1589047 interleukin 20 receptor, alpha IL20RA -1,0358415 -1,4305781 -1,7288384 -1,6813605 interleukin 24 IL24 1,106633 -1,0010992 1,006788 2,7294762 interleukin 28A (interferon, lambda 2) | interleukin 28B (interferon, lambda 3) IL28A|IL28B -1,2154096 1,7803884 -1,0162554 -1,5526619 interleukin 31 receptor A IL31RA 33,179085 31,800442 30,650517 25,447344 interleukin 33 IL33 -1,0510402 3,3249323 4,5300283 11,343547 interleukin 4 receptor IL4R 1,7219068 3,3331914 2,8142586 3,9415696 interleukin 6 (interferon, beta 2) IL6 1,4671061 2,0164251 1,100111 1,1330762 interleukin 7 receptor IL7R 1,7201003 1,7892618 1,6476909 4,0244613 interleukin 8 IL8 1,5243798 3,5736492 -1,0082042 1,5767655 interleukin-1 receptor-associated kinase 2 IRAK2 1,023659 1,4397186 1,2552981 1,740113 intermediate filament family orphan 2 IFFO2 1,4086603 1,5181316 1,6114701 1,5908711 internexin neuronal intermediate filament protein, alpha INA -1,1764678 -1,9193947 -1,1654617 -1,322682 intraflagellar transport 57 homolog (Chlamydomonas) IFT57 1,4338448 1,5803728 1,0928246 1,1963763 intraflagellar transport 80 homolog (Chlamydomonas) IFT80 1,1676332 -1,5298548 -1,5891458 -1,5245563 inverted formin, FH2 and WH2 domain containing INF2 -1,2008581 -1,1297171 1,2747278 1,5705667 involucrin IVL -1,557604 -1,8306372 -3,126067 -3,1149752

IQ motif containing GTPase activating protein 2 IQGAP2 1,4381196 -1,4297636 -1,7405219 -1,7175233 iron/zinc purple acid phosphatase-like protein PAPL 1,0002366 1,5014596 1,029027 1,0064113 isocitrate dehydrogenase 1 (NADP+), soluble IDH1 1,0963392 -1,8562981 -1,1386561 -1,1574699 isocitrate dehydrogenase 2 (NADP+), mitochondrial IDH2 -1,1750237 1,295747 1,7381127 2,160967 isocitrate dehydrogenase 3 (NAD+) alpha | acyl-CoA synthetase bubblegum family member 1 IDH3A|ACSBG1 1,6722027 1,5351002 1,0859836 1,0086786 isoleucyl-tRNA synthetase IARS 1,4548792 1,5529052 1,5115796 1,7739512 isopentenyl-diphosphate delta isomerase 1 IDI1 -1,1159606 1,045862 2,8556151 2,079854 jagged 2 JAG2 -1,0492524 -1,7589139 -1,3350078 -1,2872814 jub, ajuba homolog (Xenopus laevis) JUB -1,3560553 -1,913182 -1,4834393 -1,4060805 jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae) JHDM1D -1,0010377 2,1257875 2,45778 3,2791789 jun B proto-oncogene JUNB 1,7372742 1,5703943 1,4179232 1,8501813 jun proto-oncogene JUN 1,8326199 1,9820454 1,4734863 1,5597981 junction plakoglobin JUP -1,1230805 -1,5588642 -1,2450964 -1,231186

K(lysine) acetyltransferase 2B KAT2B 1,2022489 -2,1311257 -1,5579299 -1,2273462 kalirin, RhoGEF kinase KALRN 1,0812831 1,288682 1,6204783 1,6345962 kallikrein-related peptidase 5 KLK5 1,0198052 -1,364228 -1,5217623 -1,6496837 kallikrein-related peptidase 7 KLK7 -1,3027045 -1,4385737 -1,0484186 -1,8109015 kallikrein-related peptidase 8 | kallikrein-related peptidase 9 KLK8|KLK9 1,1064966 -1,0647045 1,8468821 2,0427692 karyopherin alpha 5 (importin alpha 6) KPNA5 1,0296801 -1,6915984 -1,1640445 -1,1746194 karyopherin alpha 7 (importin alpha 8) KPNA7 -1,1197592 -2,1951387 -1,8692458 -1,510068

KDEL (Lys-Asp-Glu-Leu) containing 1 KDELC1 1,3671788 -1,5095081 -1,0637172 -1,0855092 kelch repeat and BTB (POZ) domain containing 3 KBTBD3 1,0186969 -1,7082189 -1,2017618 -1,2051373 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 kelch-like 13 (Drosophila) KLHL13 1,5116285 -1,3614092 -1,8795186 -1,9829444 kelch-like 24 (Drosophila) KLHL24 1,1229988 -2,2024782 -1,2011106 -1,1156715 kelch-like 5 (Drosophila) KLHL5 1,0664514 1,2539538 1,5720873 1,5760882 kelch-like 8 (Drosophila) KLHL8 1,6938565 -1,0349151 1,142325 1,2554915 keratin 1 KRT1 -1,0208088 -2,446241 -3,3432736 -2,8770638 keratin 10 KRT10 -1,0694801 -3,111986 -4,1941943 -2,98972 keratin 13 KRT13 1,026389 -1,4844123 -1,6549051 -2,3006806 keratin 15 KRT15 1,0638441 -1,3566308 -1,4586579 -1,6161575 keratin 16 KRT16 1,0026536 -1,1649479 1,4342704 1,8818073 keratin 17 KRT17 -1,170857 1,0951325 2,214212 2,8073764 keratin 17 KRT17 -1,1910079 1,0720352 1,799462 2,7300348 keratin 17 KRT17 -1,1835684 1,0797403 1,654497 2,1496263 keratin 18 KRT18 -1,0993756 1,2636658 1,7394449 1,3872191 keratin 18 KRT18 -1,2871963 1,0450127 1,4539081 1,6130357 keratin 23 (histone deacetylase inducible) KRT23 -1,416945 -1,6340139 -1,4406744 -1,0758247 keratin 4 KRT4 -1,212201 -1,9218724 -3,5944424 -3,9787948 keratin 6A KRT6A 1,0265485 1,720935 2,289177 2,3559906 keratin 6B KRT6B -1,133924 1,9230886 4,244201 3,7957578 KRT6C|KRT6B|K keratin 6C | keratin 6B | keratin 6A RT6A 1,0649066 1,2454923 1,7580247 1,7361593 keratin 7 KRT7 -1,0266659 -1,5514061 -1,7117847 -1,8681606 keratin 77 KRT77 -1,0711126 -1,1755365 -1,4783816 -2,9967651 keratin 8 KRT8 -1,1268367 -1,5011619 1,1324663 1,0654558 keratin 80 KRT80 -1,3256853 -1,1751037 -1,2688664 -1,5319922 keratin 9 KRT9 -1,0320035 -1,1373194 -1,494537 -1,5303448 keratin associated protein 10-4 KRTAP10-4 -1,434554 1,1427794 1,0137109 -1,832764 keratin associated protein 5-3 KRTAP5-3 -1,3687246 1,2060561 -1,242895 -1,6177202 keratin associated protein 9-3 KRTAP9-3 -1,3995318 1,0808568 1,1181674 -1,6507522 keratinocyte differentiation-associated protein KRTDAP -1,2894936 -2,474472 -1,53442 -1,9284619 KIAA0101|CSNK KIAA0101 | casein kinase 1, gamma 1 1G1 -1,1393315 -1,8043504 1,1596595 1,2676604 KIAA1712|FBXO KIAA1712 | F-box protein 8 8 -1,1226894 -1,653571 -1,1789427 -1,3461059 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 | killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 | killer cell immunoglobulin-like receptor, three domains, short KIR3DL1|KIR3DL cytoplasmic tail, 1 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 | killer cell 3|KIR3DS1|KIR2 immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 | killer cell immunoglobulin-like receptor, DL3|KIR2DL4|KI two domains, long cytoplasmic tail, 5A R2DL5A -1,5449352 1,2912158 -1,1359617 -1,2128001 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 | killer cell immunoglobulin-like receptor, two domains, long KIR2DL3|KIR2DL cytoplasmic tail, 2 1|KIR2DL2 1,0038033 2,422028 -1,0306165 -1,1385117 killer cell lectin-like receptor subfamily G, member 2 KLRG2 -1,0954872 -1,2501289 -1,5167783 -1,6170728 kinectin 1 (kinesin receptor) KTN1 1,1661568 1,8704708 2,2958298 2,3935761 kinesin family member 11 KIF11 1,002319 -1,9542431 -1,0451398 1,0781274 kinesin family member 13A KIF13A 1,0234987 -1,571629 -1,3359754 -1,153707 kinesin family member 14 KIF14 1,1578686 -1,9506267 1,1078725 1,503451 kinesin family member 15 KIF15 1,0511128 -1,5903606 1,1723497 1,0648105 kinesin family member 16B KIF16B -1,0448728 -1,6391863 -1,1827956 -1,2075348 kinesin family member 18A KIF18A -1,0041002 -1,9659698 -1,0770365 1,2976863 kinesin family member 18B KIF18B -1,1675649 -1,5775261 -1,0535281 1,1218966 kinesin family member 20A | cell division cycle 23 homolog (S. cerevisiae) KIF20A|CDC23 1,0055867 -1,6188637 1,0527623 1,3983371 kinesin family member 20B KIF20B 1,1274204 -1,5571849 1,1059843 1,2084191 kinesin family member 23 KIF23 1,0741605 -1,9697663 1,0683254 1,5641714 kinesin family member 2C KIF2C 1,048639 -1,7016214 -1,1195197 1,1583195 kinesin family member C2 | forkhead box H1 KIFC2|FOXH1 -1,1992894 -1,1888303 -1,6043874 -1,2427208

KIT ligand KITLG 1,7405369 -1,073907 -1,4167268 -1,7890235 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31

KN motif and ankyrin repeat domains 1 KANK1 1,1853172 -1,6281291 -1,2445595 -1,0773188 kringle containing transmembrane protein 1 KREMEN1 -1,0598334 -2,5388386 -1,915323 -1,8956596

Kruppel-like factor 10 KLF10 1,4334695 1,2098283 1,4299432 1,6301796

Kruppel-like factor 11 KLF11 1,0479579 1,3885512 1,555651 2,2810516

Kruppel-like factor 12 KLF12 -1,0239433 -2,046559 1,154368 1,1451936

Kruppel-like factor 3 (basic) | hypothetical FLJ13197 KLF3|FLJ13197 -1,5776746 -1,9814584 -1,2356836 -1,2177869

Kruppel-like factor 5 (intestinal) KLF5 -1,6262366 -1,0099615 -1,1437777 -1,1209348

Kruppel-like factor 6 KLF6 1,6546667 1,1995844 1,5457177 1,9042503

Kruppel-like factor 8 KLF8 -1,4420546 -3,5479915 -1,2623084 -1,2266372 kynureninase (L-kynurenine hydrolase) KYNU 1,2874823 -1,0120062 3,203362 6,9293947

LAG1 homolog, ceramide synthase 6 LASS6 1,3821938 -2,3758216 -2,1880016 -2,2419572 lamin B1 LMNB1 1,3367546 -1,0207002 1,4807314 1,5039798 laminin, alpha 3 LAMA3 1,062414 1,391131 1,8247353 1,9954269 laminin, alpha 5 LAMA5 -1,0631124 -1,8731025 -1,5662599 -1,4298279 laminin, beta 1 LAMB1 1,004018 -1,0651572 1,6878549 2,1136196 laminin, beta 2 (laminin S) LAMB2 -1,0580254 -1,490217 -1,7524114 -1,4980711 laminin, gamma 2 LAMC2 1,0318879 1,0049788 1,4221191 1,9267888 latent transforming growth factor beta binding protein 1 LTBP1 -1,0566134 1,0299194 1,4942861 1,7135463 latexin LXN -1,0174717 -1,5560741 -1,1964045 -1,2031631 lectin, galactoside-binding, soluble, 3 LGALS3 -1,2416936 -1,5514841 -1,4851092 -1,4518615 lectin, galactoside-binding, soluble, 4 LGALS4 -1,0594468 1,252644 1,0472633 -1,5044019 LGALS7|LGALS7 lectin, galactoside-binding, soluble, 7 | lectin, galactoside-binding, soluble, 7B B -1,1086121 -1,376461 -1,6007162 -1,5224695 LGALS7|LGALS7 lectin, galactoside-binding, soluble, 7 | lectin, galactoside-binding, soluble, 7B B -1,1143013 -1,444148 -1,6135683 -1,550692 LGALS8|LOC100 lectin, galactoside-binding, soluble, 8 | hypothetical LOC100287902 287902 -1,0975248 1,2721603 1,0113926 -1,5577188 left-right determination factor 2 LEFTY2 -1,5264425 -1,0098611 -1,0596442 -1,1502962 legumain LGMN 1,1248176 1,0536381 1,9018248 2,3704016

LEM domain containing 1 LEMD1 1,2649395 2,0623157 2,1588 1,9078575 lethal giant larvae homolog 2 (Drosophila) LLGL2 1,0267887 -1,6767166 -1,2575601 -1,2706031

LETM1 domain containing 1 LETMD1 -1,0734435 -1,6712291 -1,1753477 -1,0034858 leucine rich repeat (in FLII) interacting protein 1 LRRFIP1 -1,1581205 -1,0450431 -1,2467502 -1,7110889 leucine rich repeat containing 28 LRRC37A2|LRRLRRC28 -1,0079713 -1,5050678 -1,0698901 -1,2139956 leucine rich repeat containing 37, member A2 | leucine rich repeat containing 37A | leucine rich repeat C37A3|LRRC37A containing 37, member A3 | leucine rich repeat containing 37, member A4 (pseudogene) 4LRRC37A2|LRR 1,0038679 -1,632571 -1,5770688 -1,3155301 leucine rich repeat containing 37, member A2 | leucine rich repeat containing 37A | leucine rich repeat C37A3|LRRC37A containing 37, member A3 | leucine rich repeat containing 37, member A4 (pseudogene) 4LRRC37A3|LRR 1,0045416 -1,6344131 -1,580937 -1,3114336 leucine rich repeat containing 37, member A3 | leucine rich repeat containing 37, member A2 | leucine rich C37A2|LRRC37A repeat containing 37A | leucine rich repeat containing 37, member A4 (pseudogene) 4LRRC37A4|LRR 1,0087899 -1,6091336 -1,5294787 -1,3064557 leucine rich repeat containing 37, member A4 (pseudogene) | leucine rich repeat containing 37, member A3 | C37A3|LRRC37A leucine rich repeat containing 37, member A2 2LRRC37A4|LRR 1,017164 -1,8968416 -1,651383 -1,3485329 leucine rich repeat containing 37, member A4 (pseudogene) | leucine rich repeat containing 37, member A3 | C37A3|LRRC37A leucine rich repeat containing 37, member A2 2 1,0209323 -1,9163717 -1,6526443 -1,340805 leucine rich repeat containing 37B LRRC37B -1,2150089 -1,6312958 -1,2829362 1,0579358 leucine rich repeat containing 4 LRRC4 1,1221169 1,694268 2,2927935 1,5764278 leucine rich repeat containing 59 LRRC59 -1,0943762 1,5070062 1,4440969 1,5507191 leucine rich repeat containing 7 LRRC7 1,1141713 -1,5532835 -1,1928926 -1,6984574 leucine zipper protein 2 LUZP2 1,5741411 -1,7202305 -2,761543 -4,147475 leucine-rich alpha-2-glycoprotein 1 LRG1 2,9059427 7,690918 3,8692987 3,6921556 leucine-rich repeat-containing G protein-coupled receptor 4 LGR4 1,0112944 -1,8385005 -1,3293358 -1,3939321 leucine-rich repeat-containing G protein-coupled receptor 6 LGR6 1,0929748 -1,6778092 -2,1184306 -1,4370834 leucine-rich repeats and immunoglobulin-like domains 3 LRIG3 -1,6017048 -1,2883183 1,078594 -1,0368745 leukocyte-associated immunoglobulin-like receptor 1 LAIR1 1,0089266 1,1252687 -1,0806528 -1,5683299 leukotriene B4 receptor | leukotriene B4 receptor 2 LTB4R|LTB4R2 1,296088 1,7031446 2,2127297 2,020765 LTB4R2|CIDEB|C leukotriene B4 receptor 2 | cell death-inducing DFFA-like effector b | chromosome 14 open reading frame 21 14orf21 1,1126889 1,6082716 1,6389235 1,3742735 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31

LIM domain 7 LMO7 -1,3081175 -1,6203916 -1,2701936 -1,5522827

LIM domain and actin binding 1 LIMA1 1,0266469 1,6039267 1,5712821 1,5460682

LIM domain kinase 2 LIMK2 -1,1646068 -1,5448463 -1,1496128 -1,3080527 limbic system-associated membrane protein LSAMP 1,0234482 1,557379 -1,0611489 -1,0578595 LIPA|LOC100509 lipase A, lysosomal acid, cholesterol esterase | hypothetical LOC100509637 637 1,1735535 1,19288 2,1070254 2,0247583 lipase, endothelial LIPG 1,9659672 2,7327232 2,4012344 2,384144 lipin 1 LPIN1 1,1446638 -1,1024667 1,5792351 2,0106564 lipin 3 | elastin microfibril interfacer 3 LPIN3|EMILIN3 -1,2370586 -1,6405765 -1,3354439 -1,426015 lipocalin 2 LCN2 1,6225481 3,2234685 4,114247 3,6364884 lipopolysaccharide binding protein LBP 1,0790215 3,435628 8,562641 8,499652 lipoprotein, Lp(a) LPA -1,0704395 1,5685798 -1,0029005 -1,2428453

LON peptidase N-terminal domain and ring finger 1 LONRF1 2,091957 1,2204624 1,2276752 1,6273571 low density lipoprotein receptor LDLR 1,690993 1,5241648 2,222133 2,8699577 low density lipoprotein receptor adaptor protein 1 LDLRAP1 -1,0752119 -1,7601422 -1,1368046 -1,0206186 low density lipoprotein receptor-related protein 1 LRP1 -1,2815927 -1,8640498 -1,6279273 -1,4292156 low density lipoprotein receptor-related protein 10 LRP10 -1,0032994 1,1303244 1,2980008 1,5573759 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor LRP8 1,2656547 2,0539086 3,0000384 3,3275864

LUC7-like 3 (S. cerevisiae) LUC7L3 1,153174 -1,4143846 -1,5270218 -1,2055062 lung carcinoma-associated protein 10 LCA10 -1,5400186 1,3160619 1,155152 -1,2945381

Ly1 antibody reactive homolog (mouse) LYAR -1,0145833 1,6793593 1,3223306 1,6355225

LY6/PLAUR domain containing 1 | G protein-coupled receptor 39 LYPD1|GPR39 1,2174569 2,354661 1,4544517 1,8608992

LY6/PLAUR domain containing 3 LYPD3 -1,4576843 -2,30735 -1,6369605 -1,5733088

LY6/PLAUR domain containing 6B LYPD6B -1,2323068 -1,8297734 -2,0212388 -1,9124385 lymphocyte antigen 6 complex, locus E LY6E 1,0635129 1,5812757 1,7140414 1,6950455 lymphocyte antigen 6 complex, locus G6C LY6G6C -1,5340838 -1,571933 -1,2921255 -1,4033788 lymphocyte antigen 6 complex, locus G6C LY6G6C -1,5449255 -1,575068 -1,3153013 -1,4694079 lymphocyte antigen 6 complex, locus G6E LY6G6E -1,1498355 -1,3657625 -1,3961836 -1,672902 lymphocyte antigen 6 complex, locus G6E LY6G6E -1,1511937 -1,3636285 -1,3952808 -1,6747692 lymphocyte antigen 6 complex, locus G6E LY6G6E -1,152566 -1,3747165 -1,397274 -1,6802244 lymphocyte antigen 96 LY96 1,0175084 1,197023 1,5082624 2,373991 lymphocyte cytosolic protein 1 (L-plastin) LCP1 -1,0806571 1,2137128 1,6545397 3,1474862

LYR motif containing 1 LYRM1 1,2363936 2,1884732 2,527493 3,0266535 lysine (K)-specific demethylase 3A KDM3A -1,6226887 -1,4968609 -1,2176389 -1,1195686 lysine (K)-specific demethylase 4A KDM4A -1,0305879 -1,8030341 -1,0856736 -1,1979254 lysine (K)-specific demethylase 5B KDM5B -1,2361475 -1,5450281 -1,4977294 -1,5108074

LysM, putative peptidoglycan-binding, domain containing 4 LYSMD4 -1,063824 -1,8686157 -1,2785033 -1,257534 lysophosphatidic acid receptor 6 LPAR6 2,971605 2,7656124 2,4324057 2,2169654 lysophosphatidylcholine acyltransferase 1 LPCAT1 1,1986562 1,6158563 1,6633115 2,1885195 lysophosphatidylcholine acyltransferase 2 LPCAT2 1,1761389 -1,5148566 -1,5438561 -1,5943685 lysophosphatidylcholine acyltransferase 3 LPCAT3 1,3333595 1,2189853 1,6563454 1,752489 lysophosphatidylcholine acyltransferase 4 LPCAT4 -1,0188047 -1,4958287 -1,3679187 -1,5375376 lysophosphatidylglycerol acyltransferase 1 LPGAT1 1,1394314 1,1033982 1,2541528 1,5014323 lysyl oxidase LOX -1,3374289 -1,1464926 1,6345103 1,9198122 lysyl oxidase-like 2 LOXL2 -1,6812192 1,0872844 2,2610538 2,4084198 lysyl-tRNA synthetase KARS 1,0376953 1,5319871 1,1173728 1,1165206

M-phase phosphoprotein 6 MPHOSPH6 1,2826008 1,918761 2,1702292 3,0412188 macrophage migration inhibitory factor (glycosylation-inhibiting factor) | solute carrier family 2 (facilitated glucose transporter), member 11 MIF|SLC2A11 -1,575532 -1,2053866 1,2203672 1,5617388 major facilitator superfamily domain containing 2A MFSD2A -1,0049654 1,1318713 1,5443379 1,6649759 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 major facilitator superfamily domain containing 2B MFSD2B -1,1086861 1,7113926 -1,0344373 -1,3763273 HLA-DMA|HLA- major histocompatibility complex, class II, DM alpha | major histocompatibility complex, class II, DM beta DMB 1,5402287 2,9542966 1,3937258 1,4999388 HLA-DMA|HLA- major histocompatibility complex, class II, DM alpha | major histocompatibility complex, class II, DM beta DMB 1,5391504 2,9634914 1,3940777 1,4961354 HLA-DMA|HLA- major histocompatibility complex, class II, DM alpha | major histocompatibility complex, class II, DM beta DMB 1,5180197 2,843211 1,3872383 1,4814774 major histocompatibility complex, class II, DM beta HLA-DMB 1,3157684 3,4644856 1,2964315 1,1441561 major histocompatibility complex, class II, DM beta HLA-DMB 1,1938317 3,1563954 1,2128073 1,1223525 major histocompatibility complex, class II, DP alpha 1 HLA-DPA1 2,1084898 6,153418 2,835076 2,196035 major histocompatibility complex, class II, DP alpha 1 HLA-DPA1 2,1074774 6,14424 2,8282104 2,1946056 major histocompatibility complex, class II, DP alpha 1 HLA-DPA1 1,9446394 5,776928 3,1148899 1,9474162 major histocompatibility complex, class II, DP beta 1 HLA-DPB1 1,3336984 4,4494305 3,2573056 1,8077542 major histocompatibility complex, class II, DP beta 1 HLA-DPB1 1,1431946 2,457394 2,447661 1,5336757 major histocompatibility complex, class II, DP beta 1 HLA-DPB1 1,2224964 2,2217216 2,3958216 1,4254792 major histocompatibility complex, class II, DQ alpha 1 HLA-DQA1 -1,1829469 4,1187997 3,1966598 1,3030028 major histocompatibility complex, class II, DQ alpha 1 HLA-DQA1 -1,1772585 4,1000137 3,2221563 1,3062441 major histocompatibility complex, class II, DQ alpha 1 HLA-DQA1 1,1581829 2,0247912 1,6636502 1,3479269 HLA-DQA2|HLA- major histocompatibility complex, class II, DQ alpha 2 | major histocompatibility complex, class II, DQ alpha 1 DQA1 -1,3137633 1,720094 1,6422931 -1,0504526 HLA-DQA2|HLA- major histocompatibility complex, class II, DQ alpha 2 | major histocompatibility complex, class II, DQ alpha 1 DQA1HLA- -1,2854408 1,6750482 1,6776811 -1,0094396 major histocompatibility complex, class II, DQ beta 1 | HLA class II histocompatibility antigen, DQ beta 1 chain- DQB1|LOC10029 like HLA-3977 1,2934817 1,6780959 1,4632877 1,1572672 major histocompatibility complex, class II, DQ beta 1 | HLA class II histocompatibility antigen, DQ beta 1 chain- DQB1|LOC10029 like HLA-DQB1|HLA-3977 1,2819663 1,6746479 1,4620124 1,1577351 major histocompatibility complex, class II, DQ beta 1 | major histocompatibility complex, class II, DR beta 1 | DRB1|LOC10013 HLA class II histocompatibility antigen, DQ beta 1 chain-like 3583|LOC100509 1,4359386 1,9078537 1,4551686 1,2746751 major histocompatibility complex, class II, DQ beta 2 HLA-DQB2 1,0473051 1,7239056 1,2648108 1,1504148 major histocompatibility complex, class II, DQ beta 2 HLA-DQB2 -1,0180601 1,5864441 1,3828775 1,1715739 major histocompatibility complex, class II, DR alpha HLA-DRA 3,223441 6,251251 2,6768 2,04749 major histocompatibility complex, class II, DR alpha HLA-DRA 2,9835248 5,695748 2,6137528 2,0969155 major histocompatibility complex, class II, DR alpha HLA-DRA 2,821059 5,4443393 2,6094627 2,073634 major histocompatibility complex, class II, DR beta 3 HLA-DRB3 1,1048889 2,3565724 2,1893747 1,3269451 HLA-DRB3|HLA- major histocompatibility complex, class II, DR beta 3 | major histocompatibility complex, class II, DR beta 1 DRB1 1,1658839 2,344636 2,1749039 1,2819715 HLA-DRB4|HLA- major histocompatibility complex, class II, DR beta 4 | major histocompatibility complex, class II, DR beta 1 DRB1 1,1923376 2,4624178 2,231064 1,3608918 major histocompatibility complex, class II, DR beta 5 HLA-DRB5 1,6190671 2,883587 2,361885 1,6445385

MAK16 homolog (S. cerevisiae) | chromosome 8 open reading frame 41 MAK16|C8orf41 1,5723695 1,4837865 1,256396 1,6662327 mal, T-cell differentiation protein MAL 1,2171322 -1,7162193 -1,5891038 -1,8570302 mal, T-cell differentiation protein-like MALL -1,5930284 1,2281038 1,4466193 1,492293 male-specific lethal 3-like 2 (Drosophila) MSL3L2 1,2192376 1,0582849 -1,0986928 1,5133562 malic enzyme 1, NADP(+)-dependent, cytosolic ME1 1,2071449 -1,0093609 1,5105567 1,5084484 malic enzyme 2, NAD(+)-dependent, mitochondrial ME2 1,3304267 1,8329645 1,4710436 1,2521791 malignant fibrous histiocytoma amplified sequence 1 MFHAS1 1,3262761 1,0623901 1,601707 1,3021457

MAM domain containing glycosylphosphatidylinositol anchor 1 MDGA1 1,1561176 -1,6027285 1,0666083 1,1030573 mannose phosphate isomerase MPI -1,5280457 1,1389414 1,0572046 1,0989267 mannosidase, alpha, class 1A, member 1 MAN1A1 1,0956571 1,3146316 1,6585783 1,510655 mannosidase, beta A, lysosomal MANBA 1,0252596 -2,0884109 -1,1840113 1,0474706 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B MGAT4B -1,0495014 -1,7192067 -1,4113008 -1,0643034

MAP kinase interacting serine/threonine kinase 2 MKNK2 -1,3528714 -1,6589105 -1,0610609 -1,0439439

MAS-related GPR, member X3 MRGPRX3 -1,0244714 1,3230016 1,5211251 1,4384001 mastermind-like 2 (Drosophila) MAML2 1,032904 -1,3269609 -1,6383353 -1,5590868 matrilin 2 MATN2 1,062834 -1,9459581 -1,6699002 -2,1740286 matrix metallopeptidase 10 (stromelysin 2) MMP10 -1,0812217 -1,5132776 1,5710157 1,8233746 matrix metallopeptidase 12 (macrophage elastase) MMP12 2,1403432 -2,5767863 -1,4596407 -1,0886779 matrix metallopeptidase 13 (collagenase 3) MMP13 1,6470876 -1,2999045 -1,1805694 -1,1252273 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 matrix metallopeptidase 28 MMP28 -1,0891418 -1,9581535 -1,7140992 -1,5669465 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) MMP9 -1,1257129 1,1755042 1,4384496 1,9450226 matrix-remodeling-associated protein 5-like LOC652811 -1,1650287 -1,1961644 -1,7444123 -1,5037035 matrix-remodelling associated 5 MXRA5 -1,1239353 -1,5314363 -2,2535467 -1,7800158

MAX dimerization protein 1 MXD1 -1,6092931 -1,0955865 1,2590382 1,3014022 mediator complex subunit 10 | dynein, axonemal, light chain 4 MED10|DNAL4 1,0171263 -1,0843093 1,1805277 1,5513625

Meis homeobox 1 MEIS1 -1,0687139 -1,9624038 -1,7082381 -1,4391159 melanoma cell adhesion molecule MCAM 1,0627772 1,2001606 1,5298396 1,0036291 melanoregulin MREG -1,0113772 -1,1053747 1,119119 1,5482614 membrane bound O-acyltransferase domain containing 1 MBOAT1 -1,1332631 -1,6846346 -1,526714 -1,7059412 membrane bound O-acyltransferase domain containing 2 MBOAT2 -1,331003 -1,5822334 1,063688 1,4449716 membrane metallo-endopeptidase MME -1,5002929 -1,2462921 1,1886216 1,4718839 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) MPP6 1,3671453 1,8364738 1,6001852 1,938363 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) MPP7 -1,126652 -2,6395936 -1,6440494 -1,7445138 met proto-oncogene (hepatocyte growth factor receptor) MET 1,4627606 2,3659127 1,6435506 1,9243004 metallophosphoesterase domain containing 1 MPPED1 -1,108634 -1,2455393 -1,535701 -1,668195 metallophosphoesterase domain containing 2 MPPED2 1,454856 -3,6121757 -4,395933 -5,730089 metallothionein 1 pseudogene 2 MT1P2 -1,0638832 1,6434627 1,3602861 1,4391582 metallothionein 1A MT1A 1,0733757 1,6928765 1,1312801 1,1965436 metallothionein 1D (pseudogene) MT1DP -1,246012 1,5421894 1,4641856 1,5402384 metallothionein 1G MT1G -1,1848584 1,7037605 1,6489091 1,6636491 metallothionein 1H MT1H -1,2282848 1,5336772 1,4130259 1,1935958 metallothionein 1J (pseudogene) | metallothionein 1M MT1JP|MT1M -1,1103411 1,5564641 1,4626402 1,3577774 metallothionein 1L (gene/pseudogene) MT1L -1,1019214 1,1425837 1,1841053 1,6859603 metallothionein 1X MT1X -1,8150355 1,337451 1,1287228 1,20788 metallothionein 2A MT2A -1,012683 1,9246387 1,7960656 2,214651 metallothionein 2A MT2A -1,0192573 1,8883456 1,7476752 2,1024048 metallothionein 2A MT2A -1,012979 1,5717372 1,6747537 2,2517345 metastasis associated in colon cancer 1 MACC1 -1,0862176 -1,4968297 -1,8916677 -2,0551472 metastasis suppressor 1-like MTSS1L -1,1010746 -1,7344662 -1,2223493 -1,0551931 methionine adenosyltransferase II, alpha MAT2A 1,5593858 1,5362818 1,0576135 1,2531148 methionyl aminopeptidase 1 METAP1 1,016416 -1,5504106 -1,5157089 -1,6803893 methionyl-tRNA synthetase MARS 1,3991096 1,5539649 1,4705088 1,8874807 methylcrotonoyl-CoA carboxylase 1 (alpha) MCCC1 1,1081178 -1,3711983 -1,5208149 -1,617293 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like MTHFD1L|LOC1MTHFD1L 1,0821083 2,0006287 2,0170643 2,3984091 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | hypothetical LOC100133920 | 00133920|LOC28 hypothetical LOC286297 | monofunctional C1-tetrahydrofolate synthase, mitochondrial-like 6297|LOC100506MTHFD1L|LOC1 1,0047705 1,8408037 1,674498 2,3541374 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | hypothetical LOC100133920 | 00133920|LOC28 hypothetical LOC286297 | monofunctional C1-tetrahydrofolate synthase, mitochondrial-like 6297|LOC100506MTHFD1L|LOC1 -1,0238854 1,7523018 1,7361611 2,16412 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | hypothetical LOC100133920 | 00133920|LOC28 hypothetical LOC286297 | monofunctional C1-tetrahydrofolate synthase, mitochondrial-like 6297|LOC100506MTHFD1L|LOC1 1,0030795 1,6600766 1,4220966 2,0157254 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | hypothetical LOC100133920 | 00133920|LOC28 hypothetical LOC286297 | monofunctional C1-tetrahydrofolate synthase, mitochondrial-like 6297|LOC100506 -1,0041041 1,6577573 1,4262064 1,9997964 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase MTHFD2 1,4401983 2,7587543 3,1034768 3,9295194 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase MTHFD2 1,4108498 2,530584 2,4093378 2,739733 methylmalonic aciduria (cobalamin deficiency) cblB type MMAB -1,049586 -1,0227581 1,6342943 1,2477684 methyltransferase 5 domain containing 1 METT5D1 1,114424 -1,471896 -1,5167799 -1,045222 methyltransferase like 1 METTL1 1,4195963 2,6883707 1,359527 1,2650056 methyltransferase like 4 METTL4 -1,0141194 -1,5486283 -1,299587 1,0021864 methyltransferase like 7A METTL7A 1,1463248 -2,1026726 -1,9143041 -1,9288833 mevalonate (diphospho) decarboxylase MVD -1,0557059 -1,1251024 1,6210065 1,5523756

MGC44478 FDPSL2A 1,1455868 1,1593882 1,515465 2,0683537 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31

MGC44478 FDPSL2A 1,156731 1,137657 1,4449263 1,9874784

MHC class I polypeptide-related sequence B MICB -1,0253602 -1,018478 1,5411234 1,4776034 microfibrillar-associated protein 3-like MFAP3L 1,0077142 -1,9324784 -1,283788 -1,1702286 microRNA 107 MIR107 -1,0426525 1,3892843 -1,0091827 -1,5262704 microRNA 124-2 MIR124-2 -1,1150488 1,6761642 1,0838107 1,1113305 microRNA 134 MIR134 -1,2764893 1,5542572 -1,1132919 -1,0250858 microRNA 150 MIR150 -1,3554964 -1,0086925 1,0821394 -1,5138655 microRNA 15a MIR15A -1,2866535 -1,907944 -1,3049854 -1,1016294 microRNA 181b-1 MIR181B1 -1,454708 -1,2849824 -1,579861 -1,449408 microRNA 186 MIR186 1,3142767 -1,823459 -1,7990725 1,0588002 MIR205|LOC642 microRNA 205 | NPC-A-5 587 -1,1243299 -1,715118 -1,9480895 -1,7838984 microRNA 21 MIR21 1,9757115 1,3364125 1,4753323 2,0986004 microRNA 221 MIR221 1,0607958 -1,5665628 -1,5453677 -1,3920946 microRNA 224 | gamma-aminobutyric acid (GABA) A receptor, epsilon MIR224|GABRE 1,2872448 -1,7828168 -1,8880248 -1,6381036 microRNA 23b | chromosome 9 open reading frame 3 MIR24-MIR23B|C9orf3 -1,5890455 -1,759322 -2,1105592 -1,8003591 1|MIR3074|C9orf microRNA 24-1 | microRNA 3074 | chromosome 9 open reading frame 3 3 -1,3198531 -2,2132192 -1,9153585 -1,4021543 microRNA 27b | chromosome 9 open reading frame 3 MIR27B|C9orf3 -1,7487222 -2,3092139 -1,8729217 -1,5706041 microRNA 29a MIR29A 2,344667 1,315523 1,1227651 1,5700928 microRNA 30e MIR30E 1,0082802 -1,5289868 -1,6187402 -1,4219645 microRNA 31 MIR31 1,3972057 1,0079157 1,0736103 1,577171 microRNA 32 MIR32 -1,4417391 -2,1605608 -1,6463001 -1,3488405 microRNA 326 MIR326 -1,2909311 1,4276208 -1,1701359 -1,5587561 microRNA let-7a-2 MIRLET7A2 -1,1185966 -1,6612155 -1,070172 1,2893239 microRNA let-7f-1 MIRLET7F1 1,580329 -1,2568355 -1,3962704 1,0217148 microRNA let-7g MIRLET7G 1,122938 -1,3439081 -1,3535562 -1,5599054 microsomal glutathione S-transferase 2 MGST2 1,1646122 -1,8409868 -1,3735183 -1,4029856 microtubule associated monoxygenase, calponin and LIM domain containing 2 MICAL2 1,1823231 -1,0114962 1,1488007 1,511213 microtubule associated tumor suppressor 1 MTUS1 1,0676763 -1,5999229 -1,6004682 -1,4769458 microtubule associated tumor suppressor candidate 2 MTUS2 1,0439539 -1,2292767 -1,4582477 -1,8652484 microtubule-actin crosslinking factor 1 MACF1 -1,0307581 1,4815313 1,886246 2,1401155 microtubule-actin crosslinking factor 1 MACF1 -1,0754073 1,1995772 1,8605862 1,9273156

MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish)) MID1IP1 1,5627105 2,0538788 1,8758037 2,1884565 minichromosome maintenance complex component 6 MIR17HG|MIR19MCM6 1,2792621 1,3088199 1,6402414 1,3908983 MIR17 host gene (non-protein coding) | microRNA 17 | microRNA 19a | microRNA 19b-1 | microRNA 20a | A|MIR19B1|MIR2 microRNA 92a-1 | microRNA 18a 0A|MIR92A1|MIR 2,4348807 2,0229611 1,325096 1,5085939 misshapen-like kinase 1 | cholinergic receptor, nicotinic, epsilon MINK1|CHRNE 1,2401063 1,7498126 1,5712115 1,6636326 mitochondrial translational release factor 1 MTRF1 1,1247648 -1,6955541 -1,0993146 -1,1787221 mitogen-activated protein kinase 10 MAPK10 -1,0571853 -2,0718904 -1,7882745 -2,1004102 mitogen-activated protein kinase 15 MAPK15 1,0428365 1,2423501 -1,1767198 -1,5066919 mitogen-activated protein kinase kinase 6 MAP2K6 1,480471 -2,332716 -1,8287523 -1,0359982 mitogen-activated protein kinase kinase kinase 2 MAP3K2 -1,0540972 -1,7844539 -1,5577404 -1,3132354 mitogen-activated protein kinase kinase kinase 4 MAP3K4 -1,0640594 -1,6978018 -1,3614659 -1,2513599 mitogen-activated protein kinase kinase kinase 5 MAP3K5 1,0943321 1,5119803 1,5794069 1,7716647 mitogen-activated protein kinase kinase kinase kinase 4 MAP4K4 1,068257 1,2071911 1,5629213 1,7492702 mixed lineage kinase domain-like MLKL 1,247317 1,5808493 1,2920585 1,5801227 moesin MSN 1,0868605 1,2870499 1,7119815 1,4034758 molybdenum cofactor sulfurase MOCOS 1,9558663 1,6599817 1,4628356 1,6237981 molybdenum cofactor synthesis 2 MOCS2 1,0033611 1,0893694 1,3672144 1,6635078 monoamine oxidase A MAOA -1,185077 -1,8720949 -1,2462616 -1,9964586 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 MORC3|DOPEY MORC family CW-type zinc finger 3 | dopey family member 2 2 1,5024039 -1,0776517 1,0982454 1,2498083 MPV17L2|RAB3 MPV17 mitochondrial membrane protein-like 2 | RAB3A, member RAS oncogene family A 1,2940564 1,3431453 1,8250538 1,3578573

MRE11 meiotic recombination 11 homolog A (S. cerevisiae) MRE11A -1,1225466 -1,5160992 -1,0383838 1,0875663 mRNA turnover 4 homolog (S. cerevisiae) MRTO4 1,294821 1,9273506 1,2214165 1,3853661

MTERF domain containing 1 MTERFD1 1,5068473 1,188093 1,0541617 1,1755431

MTERF domain containing 3 MTERFD3 1,6018187 -1,0177091 -1,08386 -1,0271852 mucin 1, cell surface associated MUC1 -1,4223298 -1,03028 1,8996499 2,6666555 mucin 12, cell surface associated MUC12 1,080139 1,5256466 1,3519769 -1,1758015 mucin 16, cell surface associated MUC16 -1,2091271 -1,8807963 -2,0085588 -2,4800506 mucin 20, cell surface associated MUC20 1,0563269 -1,7912784 -1,8355005 -1,801474 mucin 4, cell surface associated MUC4 1,2447425 2,9769468 4,7726774 2,719273 multiple C2 domains, transmembrane 1 MCTP1 1,0098411 1,222052 1,3264763 1,9716611 multiple C2 domains, transmembrane 2 MCTP2 1,2598991 1,4007591 1,7537266 2,1287222 multiple EGF-like-domains 9 MEGF9 -1,1018595 -2,2327652 -1,6307535 -1,7516863 musculin MSC 1,1482013 1,3210326 1,5442352 1,5585562 mutL homolog 3 (E. coli) MLH3 1,5209752 1,3352611 1,397244 1,4015065 MYBBP1A|SPNS MYB binding protein (P160) 1a | spinster homolog 2 (Drosophila) 2 1,1316462 1,5306402 1,2273117 1,2292039

MYC induced nuclear antigen MINA 1,5923772 1,8688189 1,4910891 1,5192449 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 MLLT3 -1,1855361 -1,7969884 -1,1811174 -1,0552737 myeloid/lymphoid or mixed-lineage leukemia 3 MLL3 -1,0103936 -1,5731809 -1,3938224 -1,2925107

MyoD family inhibitor MDFI 1,356743 2,1165948 2,1452315 2,4588742 myoglobin MB 1,0628847 1,1440072 -1,2009498 -1,9572884 myosin binding protein C, fast type MYBPC2 1,1062242 1,2645328 5,644457 6,0351853 myosin regulatory light chain interacting protein MYLIP -1,3925543 -2,9959025 -1,833522 -1,8896992 myosin VA (heavy chain 12, myoxin) MYO5A 1,0020514 -1,1585232 1,394935 1,5444797 myosin XIX MYO19 1,5251262 1,4837825 1,0903175 1,0138385 myosin, heavy chain 14, non-muscle MYH14 -1,2629347 -1,6083976 -1,66456 -1,5385792 myosin, light chain 12A, regulatory, non-sarcomeric MYL12A 1,2206779 1,545047 1,2764876 1,2952546 myotubularin related protein 10 | FANCD2/FANCI-associated nuclease 1 MTMR10|FAN1 -1,0469397 -1,6062503 -1,4234377 -1,4440119 myotubularin related protein 4 MTMR4 -1,1516436 -1,2596309 -1,2640676 -1,5214479 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) MX1 1,2499784 1,4177784 1,7956442 3,4341986 myxovirus (influenza virus) resistance 2 (mouse) MX2 -1,1401649 1,1356369 1,6177876 2,2943013

N-acetylated alpha-linked acidic dipeptidase-like 2 NAALADL2 1,0906137 -1,8250761 -3,131087 -1,874595

N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) NPL -1,0570819 -3,2118435 -1,7541504 -1,7173996

N-acetylneuraminic acid synthase NANS 1,5104749 1,7078029 1,242592 1,1623541

N-acetyltransferase 10 (GCN5-related) NAT10 1,2926509 1,5493615 1,1780467 1,270824 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 | N-acylsphingosine amidohydrolase (non- ASAH2|ASAH2B| lysosomal ceramidase) 2B | N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2C ASAH2C 1,2103274 1,5844325 1,3543092 1,3578613

N-myc (and STAT) interactor NMI 1,2052404 1,3652416 1,7261537 1,9591867

N-myc downstream regulated 1 NDRG1 -2,4951262 -1,0888834 1,1335988 1,5418581

N-sulfoglucosamine sulfohydrolase SGSH 1,0530431 1,4591705 1,6724045 1,9065293

N(alpha)-acetyltransferase 15, NatA auxiliary subunit NAA15 1,608958 1,7099401 1,3497226 1,292486

Na+/H+ exchanger domain containing 2 NHEDC2 2,671187 3,56464 5,446744 6,249454

NAD(P) dependent steroid dehydrogenase-like NSDHL -1,1716319 -1,0546178 1,5016642 1,550094

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4 NDUFAF4 1,8992852 2,0112865 1,1837922 1,1683929

NCK adaptor protein 2 NCK2 -1,1234065 -1,7604016 -1,3232907 -1,3925866

NDRG family member 2 NDRG2 1,0578434 -1,0743963 -1,8175737 -1,9052323

NDRG family member 4 NDRG4 1,0214865 -3,6781957 -2,0597796 -2,040444 nebulette NEBL -1,1123128 -2,3725963 -2,7696545 -2,777542 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 nephroblastoma overexpressed gene NOV -1,336364 1,0062175 1,6294814 1,3294549 nephronectin NPNT -1,1082157 -1,2432743 -1,2718589 -1,9066837 neural precursor cell expressed, developmentally down-regulated 4 NEDD4 1,3776312 1,2812098 1,4712623 1,687654 neural precursor cell expressed, developmentally down-regulated 4-like NEDD4L 1,1371353 1,4379538 1,433189 2,283434 neural precursor cell expressed, developmentally down-regulated 9 NEDD9 -1,4339386 -1,9921155 -1,5862795 -2,0348318 neuregulin 1 NRG1 2,315411 3,469179 2,7097952 3,256581 NRG1|LOC10050 neuregulin 1 | hypothetical protein LOC100507358 7358 1,979814 3,9134266 2,9427912 3,903548 neuregulin 4 NRG4 -1,5282174 -3,93023 -1,899852 -1,9839946 neuritin 1 NRN1 -1,6509203 -1,1558367 1,2263442 1,1568542 neurobeachin-like 1 NBEAL1 -1,080208 -1,6400522 -1,2820138 -1,0826535 neurobeachin-like 1 NBEAL1 -1,0622911 -1,9237567 -1,093528 -1,2186236 neurofascin NFASC -1,0842499 -1,3557389 -1,5666912 -1,4186451 NEFL|LOC10012 neurofilament, light polypeptide | hypothetical LOC100129717 9717 -1,671017 -2,0978944 -1,2218246 -1,3542224 neuromedin B NMB -1,5901368 1,2463295 -1,1880031 -1,3525897 neuromedin U NMU -1,3758647 -2,7386112 -2,6042397 -3,5365574 neuron navigator 1 NAV1 1,074588 1,2078688 1,26687 1,5077106 neuron navigator 2 NAV2 1,0084668 -1,5653014 -1,1942066 -1,0698806 neuron navigator 3 NAV3 1,0491407 -1,0307381 1,1393745 1,5537646 neuronal PAS domain protein 2 NPAS2 -1,0697808 -1,1365712 1,0560622 1,730895 neuropilin 2 NRP2 2,2081132 2,5152252 1,8076358 2,0127401 neutral cholesterol ester hydrolase 1 NCEH1 1,1393489 1,284461 1,6546426 1,3889469 neutrophil cytosolic factor 2 NCF2 -1,2606597 -3,547194 -1,5478956 -1,097458

NFKB activating protein pseudogene 1 NKAPP1 -1,1261721 -1,7116195 -1,3326633 -1,5612134

NHL repeat containing 3 NHLRC3 -1,0912144 -1,5080152 -1,078507 -1,005857 nicotinamide N-methyltransferase NNMT -1,0884728 1,3769028 1,4602226 1,9264997 nicotinamide phosphoribosyltransferase NAMPT 1,597166 3,487598 3,092768 4,126114 nicotinamide phosphoribosyltransferase NAMPT 1,5847572 3,426628 2,9923182 4,312599 nidogen 1 NID1 1,3580359 1,6429543 2,02124 2,5345342

Niemann-Pick disease, type C1 NPC1 1,30249 1,4227736 2,565311 3,2164743

NIMA (never in mitosis gene a)-related kinase 2 NEK2 -1,0179214 -1,7348549 1,1751888 1,105272

NIMA (never in mitosis gene a)-related kinase 6 NEK6 1,2341962 1,4096277 1,4534377 1,5383844

NIMA (never in mitosis gene a)-related kinase 7 NEK7 -1,028122 -1,6713904 -1,1551065 -1,0031469

NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) NOB1 1,1194073 -1,1299075 1,0649093 1,5749977 ninein (GSK3B interacting protein) NIN -1,0456864 -1,3828984 -1,5156097 -1,3113278

NIPA-like domain containing 1 NIPAL1 -1,1285024 1,5186957 1,7833784 1,3657845

NIPA-like domain containing 3 NIPAL3 -1,0869977 -1,2199632 -1,3269398 -1,744685

NIPA-like domain containing 4 NIPAL4 1,2554413 2,1945446 2,1446593 2,3077626

NLR family, CARD domain containing 5 NLRC5 1,0776322 -1,517352 -1,1387985 -1,0896289

NmrA-like family domain containing 1 pseudogene LOC344887 -1,7307612 -1,7997594 1,2965893 1,5632261 non-metastatic cells 1, protein (NM23A) expressed in | NME1-NME2 readthrough | non-metastatic cells 2, NME1|NME1- protein (NM23B) expressed in NME2 1,7347908 2,0009654 1,2722831 1,3465252 NCRNA00152|L non-protein coding RNA 152 | hypothetical LOC541471 OC541471 1,2256521 1,5618782 1,2103666 1,55838 NCRNA00152|L non-protein coding RNA 152 | hypothetical LOC541471 OC541471 1,385226 1,5316094 1,2061255 1,5344763 non-protein coding RNA 204 NCRNA00204 1,0712072 -1,7140403 -1,3592232 -1,2965597 non-protein coding RNA 204 NCRNA00204 1,0993375 -1,8023596 -1,359815 -1,3270952 non-protein coding RNA 260 NCRNA00260 1,0014031 -1,6587521 -1,1239146 -1,2642913 non-protein coding RNA 287 NCRNA00287 1,0515461 -1,5704426 -1,3900937 -1,3834767 non-SMC condensin I complex, subunit D2 NCAPD2 1,0664183 -1,5765362 -1,1731145 1,0877655 non-SMC element 1 homolog (S. cerevisiae) NSMCE1 1,0817478 1,375011 1,767768 1,7448967 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 nonhomologous end-joining factor 1 | solute carrier family 23 (nucleobase transporters), member 3 NHEJ1|SLC23A3 -1,0451356 -1,6237777 -1,0794474 -1,0043389 NOP56|SNORD5 NOP56 ribonucleoprotein homolog (yeast) | small nucleolar RNA, C/D box 56 6 1,4057157 1,6409925 1,3189194 1,4021062 notch 1 NOTCH1 -1,2845477 -2,9967859 -2,392072 -2,6299245 notch 3 NOTCH3 -1,1461602 -2,1896715 -1,5254177 -1,6200006 nuclear factor (erythroid-derived 2)-like 2 NFE2L2 1,4003712 1,594006 1,4989666 1,5825117 nuclear factor (erythroid-derived 2), 45kDa NFE2 1,6002179 1,6921593 2,2540457 1,9685141 nuclear factor, interleukin 3 regulated NFIL3 1,6482514 1,6223615 1,5845718 1,3499707 nuclear fragile X mental retardation protein interacting protein 2 NUFIP2 1,6018711 1,0076029 1,0241477 1,0269021 nuclear mitotic apparatus protein 1 NUMA1 1,0297713 -1,5280104 -1,3174176 -1,277884 nuclear receptor coactivator 1 NCOA1 1,0673848 1,3601112 1,279095 1,6441749 nuclear receptor coactivator 2 NCOA2 -1,1361562 -1,5777044 -1,1937153 -1,2841333 nuclear receptor coactivator 3 NCOA3 1,089682 -1,8206942 -1,5987388 -1,445867 nuclear receptor coactivator 7 NCOA7 1,991209 2,5091372 1,472682 2,1366148 nuclear receptor interacting protein 1 NRIP1 1,3771304 1,317031 1,250963 1,742339 nuclear receptor subfamily 1, group D, member 2 NR1D2 1,0724216 -1,6353598 -1,4979957 -1,2407492 nuclear receptor subfamily 2, group F, member 2 NR2F2 -1,0980284 -1,4351842 -1,2530018 -1,5156659 nuclear receptor subfamily 4, group A, member 2 NR4A2 1,8763989 1,87053 1,5126356 1,2143154 nucleolar and coiled-body phosphoprotein 1 NOLC1 1,5541826 2,246109 1,5834001 1,6605408 nucleolar and spindle associated protein 1 NUSAP1 -1,0111226 -1,6901504 -1,0697346 1,4003749 nucleolar complex associated 2 homolog (S. cerevisiae) NOC2L 1,0697027 1,5120643 1,1932199 1,1953862 nucleolar complex associated 3 homolog (S. cerevisiae) NOC3L 1,4127774 1,4784598 1,292803 1,5897263 NOL3|KIAA0895 nucleolar protein 3 (apoptosis repressor with CARD domain) | KIAA0895-like L -1,5779625 -1,3361431 -1,3663327 -1,3519229 nucleolin NCL 1,1145724 1,5019649 1,1334617 1,2348874 nucleoporin 107kDa NUP107 1,2624756 1,1096594 1,3449683 1,5032015 nucleoporin 210kDa NUP210 1,09478 1,391492 1,426633 1,5422215 nucleotide binding protein-like NUBPL 1,5704919 -1,0134501 -1,101849 -1,0017407 nudix (nucleoside diphosphate linked moiety X)-type motif 4 NUDT4 1,0608449 -1,5004084 -1,1664108 -1,0070626 OCLN|LOC64785 occludin | occludin pseudogene 9 -1,4250025 -1,3577433 -1,3706477 -1,6932973 odz, odd Oz/ten-m homolog 3 (Drosophila) ODZ3 1,1859998 1,0606856 1,550527 1,5305998 olfactomedin 1 OLFM1 1,0193217 1,0156963 1,1598952 1,523076 olfactomedin 4 OLFM4 2,368623 3,0562973 10,064114 11,797643 olfactomedin-like 2A OLFML2A 1,0012535 -1,7877917 -1,8379349 -2,007684 olfactory receptor, family 2, subfamily B, member 6 OR2B6 1,1360416 -1,7828562 1,1098465 1,24177 olfactory receptor, family 2, subfamily L, member 8 OR2L8 1,4233263 1,5612047 1,0969565 -1,1261572 olfactory receptor, family 2, subfamily Z, member 1 OR2Z1 -1,2073252 1,056909 -1,1671971 -1,5578161 olfactory receptor, family 7, subfamily E, member 91 pseudogene OR7E91P 1,04482 -1,0314493 -1,2781172 -1,6036118 oligonucleotide/oligosaccharide-binding fold containing 2A OBFC2A 2,669668 4,4594393 6,476701 5,844666 oligophrenin 1 OPHN1 1,1620955 -1,620073 -2,052421 -1,8826516 oncostatin M receptor OSMR 1,3659245 2,338283 2,3518627 3,0242186

Opa interacting protein 5 OIP5 -1,042597 -1,6520392 1,1177938 1,4442058 organic solute transporter alpha OSTalpha 1,0290123 1,3700087 1,9142263 1,4873852 ornithine decarboxylase 1 ODC1 1,196813 1,9430326 3,0311363 4,3378854 otolin 1 homolog (zebrafish) OTOL1 -1,1164988 1,5022975 -1,0403816 -1,4010861 OTUD7A|LOC10 OTU domain containing 7A | hypothetical LOC100288637 0288637 1,255902 -2,1308777 -1,0932226 -1,0278182 outer dense fiber of sperm tails 2-like ODF2L 1,1622807 -1,3469881 1,056116 1,5796726 ovarian cancer-related protein 1 OCR1 1,3725885 -1,8238134 -1,9634892 -2,0468931 ovo-like 1(Drosophila) OVOL1 -2,005184 -1,7651688 -1,1036031 -1,2021818 ovo-like 2 (Drosophila) OVOL2 -1,256588 -1,8153336 -1,6176486 -1,5165408 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 ovostatin | ovostatin 2 OVOS|OVOS2 1,6669471 -1,1377469 3,8790958 7,3208475 ovostatin | ovostatin 2 OVOS|OVOS2 1,5726179 -1,0498205 3,7578683 7,101095 ovostatin 2 OVOS2 -1,0403416 1,0325593 1,1611637 3,0300806 oxidation resistance 1 OXR1 -1,2119186 -1,9102975 -1,3615618 -1,0800105 oxidized low density lipoprotein (lectin-like) receptor 1 OLR1 -1,067923 1,7090846 1,9941926 1,831556 oxysterol binding protein-like 7 OSBPL7 -1,1229331 -1,2147462 -1,4825271 -1,5626775 p21 protein (Cdc42/Rac)-activated kinase 3 PAK3 1,192128 1,3073283 1,7107536 1,2326747

PAK1 interacting protein 1 PAK1IP1 1,3453356 1,6740575 1,3081185 1,3959959 palmdelphin PALMD -1,029299 1,2831177 1,5726808 1,2675527 palmitoyl-protein thioesterase 2 | EGF-like-domain, multiple 8 PPT2|EGFL8 -1,1404034 -1,5110061 -1,4434751 -1,4720562 palmitoyl-protein thioesterase 2 | EGF-like-domain, multiple 8 PPT2|EGFL8 -1,1539068 -1,5235387 -1,4502869 -1,4794447 pancreatic lipase-related protein 3 PNLIPRP3 -1,3998543 -3,0148592 -1,0237887 1,7989833 pannexin 1 PANX1 1,2423931 1,4953997 1,3926371 1,7029295

PAP associated domain containing 7 PAPD7 1,00414 -1,5779896 -1,2737305 -1,153139 papilin, proteoglycan-like sulfated glycoprotein | NDRG family member 2 PAPLN|NDRG2 -1,0678693 -1,6088485 -1,6332402 -1,49919 par-6 partitioning defective 6 homolog gamma (C. elegans) PARD6G -1,1298101 -2,2215624 -1,2960186 -1,1793951 PNMA6A|LOC10 paraneoplastic antigen like 6A | similar to paraneoplastic antigen-like protein 6A 0287428 -1,157776 1,1859998 -1,3252875 -1,5618771 parathyroid hormone-like hormone PTHLH 1,6388888 1,5081013 1,4515841 1,9051076 partner of NOB1 homolog (S. cerevisiae) PNO1 1,711706 1,5747275 1,1534497 1,3315864 patatin-like phospholipase domain containing 2 PNPLA2 -1,2340232 -1,5986722 -1,6706858 -1,4151534 patatin-like phospholipase domain containing 8 PNPLA8 1,245699 1,050337 1,3508022 1,579507 paxillin PXN 2,081682 1,5329165 1,6502836 1,6507664 paxillin PXN 1,3942952 1,9216653 1,9472604 2,2324967

PC4 and SFRS1 interacting protein 1 PSIP1 1,0837573 -1,6094767 -1,0615983 1,2687167

PDLIM1 interacting kinase 1 like PDIK1L -1,5199385 -1,6076334 -1,2996647 -1,3871068

PDZ and LIM domain 1 PDLIM1 -1,0784564 -1,4712167 -1,6145132 -1,7991623

PDZ and LIM domain 4 PDLIM4 -1,6789614 -1,2987599 -1,3373989 -1,5921426

PDZK1 interacting protein 1 PDZK1IP1 1,0369027 2,650405 5,59874 6,125146 pellino homolog 1 (Drosophila) PELI1 -1,4732891 -2,1046178 -1,4207952 -1,3647981 peptidase D PEPD 1,1120805 -1,0178851 1,1496515 1,5573976 peptidase inhibitor 3, skin-derived PI3 1,0267191 1,8743002 2,4039836 5,677554 peptide YY PYY -1,2403405 1,5860184 1,1025262 -1,4047427 peptidoglycan recognition protein 3 PGLYRP3 -1,266958 -2,8791878 -2,1935925 -2,1865125 peptidoglycan recognition protein 4 PGLYRP4 -1,2361145 -1,6098895 -2,9093678 -3,3738582 peptidyl arginine deiminase, type II PADI2 -1,2117323 1,0356559 -1,2935237 -1,8430227 peptidyl-tRNA hydrolase 2 PTRH2 1,3692368 1,4653969 1,5426009 1,5846807 peptidylprolyl isomerase (cyclophilin)-like 1 PPIL1 1,2943187 1,6722519 1,3683003 1,2952709 peptidylprolyl isomerase F PPIF 1,8364332 2,0196793 1,5985085 1,550751 perilipin 3 PLIN3 -1,0456636 1,2493532 1,5842167 1,7333177 perilipin 4 PLIN4 1,0494035 1,7040595 -1,0290735 -1,1463611 period homolog 2 (Drosophila) PER2 -1,4240053 -1,379109 -1,7584844 -1,6951507 period homolog 3 (Drosophila) | urotensin 2 PER3|UTS2 -1,0681436 -1,6306776 -1,9848275 -1,4061089 peripheral myelin protein 22 PMP22 -1,1499084 1,0636691 1,4527926 1,5645814 periplakin PPL -1,4549474 -1,5597857 -1,1603665 -1,2302066 peroxidasin homolog (Drosophila) PXDN -1,0674007 -1,1076982 1,215016 1,5658426 peroxisomal membrane protein 4, 24kDa PXMP4 1,2797332 -1,7482333 -1,4576578 -1,3731766 peroxisome proliferator-activated receptor gamma, coactivator-related 1 PPRC1 2,206975 1,9030359 1,3123442 1,4905007

PHD finger protein 11 PHF11 1,2845328 -1,0355594 -1,0727448 1,6682887 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 phenylalanyl-tRNA synthetase, beta subunit FARSB 1,5366445 2,1124156 1,6281728 1,6253918 phorbol-12-myristate-13-acetate-induced protein 1 PMAIP1 1,01784 1,0547531 1,2198244 1,5720531 phosphatidylglycerophosphate synthase 1 PGS1 1,3820302 1,6688502 2,2650046 2,3849218 phosphatidylinositol 4-kinase type 2 alpha PI4K2A -1,4581796 -1,6154665 1,03893 1,0707208 phosphatidylinositol glycan anchor biosynthesis, class F PIGF 1,0143603 -1,5743508 1,0452296 1,1388203 phosphatidylinositol glycan anchor biosynthesis, class W PIGW 1,8118402 1,8254689 1,3267618 1,5772731 phosphatidylinositol transfer protein, cytoplasmic 1 PITPNC1 -1,0657164 1,4276184 1,1076913 1,9490356 phosphodiesterase 7A PDE7A 1,0102667 -1,5755808 1,1220394 1,1353056 phosphodiesterase 8A PDE8A -1,2567458 1,0323975 1,8168229 2,6412125 phosphofructokinase, platelet PFKP -1,799249 1,13329 -1,0086398 -1,0336328 phosphoglucomutase 1 PGM1 -1,7233285 -1,1274099 -1,0190293 -1,1134825 phosphogluconate dehydrogenase PGD 1,0599686 -1,2557019 1,415391 1,5768781 phosphoglycerate kinase 1 PGK1 -1,8840303 -1,0508022 -1,037255 1,0257006 phosphoinositide-3-kinase interacting protein 1 PIK3IP1 -1,3599521 -2,1835473 -1,5819606 -1,2735546 phosphoinositide-3-kinase, catalytic, beta polypeptide PIK3CB -1,0731051 -1,6591375 -1,1707889 -1,1208637 phosphoinositide-3-kinase, class 2, beta polypeptide PIK3C2B -1,2306011 -2,4471822 -1,5088692 -1,7921578 phosphoinositide-3-kinase, class 2, gamma polypeptide PIK3C2G 1,4092754 -1,4208835 1,3446985 1,8531839 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) PIK3R3 1,0136924 -2,35693 -1,3114587 -1,5362697 phospholipase A2 receptor 1, 180kDa PLA2R1 1,3275707 -1,1160927 -1,3052938 -2,047831 phospholipase A2, group IIA (platelets, synovial fluid) PLA2G2A 1,7080817 2,0085588 3,532227 1,7117112 phospholipase A2, group IVD (cytosolic) PLA2G4D -1,3229141 1,1931859 1,2729036 2,2296968 phospholipase A2, group IVE PLA2G4E 1,1499013 3,4482603 4,5777 7,044216 phospholipase A2, group VI (cytosolic, calcium-independent) PLA2G6 1,0602556 -1,1499848 -1,5643989 -1,7787579 phospholipase A2, group X PLA2G10 1,1477468 -5,678175 -3,428885 -1,7027832 phospholipase A2, group XVI PLA2G16 1,1717132 1,6210258 1,2908441 -1,0909778 phospholipase B1 PLB1 -1,1944486 -1,2948813 -1,4549797 -1,6377165 phospholipase C, delta 1 PLCD1 -1,3733277 -2,5404863 -1,6851948 -1,5504987 phospholipase C, delta 3 PLCD3 -1,1869421 -2,0171556 -1,1388564 -1,0014216 phospholipase C, delta 4 PLCD4 -1,0622426 -1,6972805 -1,2554579 -1,1813024 phospholipase C, epsilon 1 PLCE1 1,6184491 -2,0579755 -2,3561099 -2,3216927 phospholipase C, eta 2 PLCH2 -1,1184136 -1,3963609 -1,3637335 -1,5748973 phospholipase C, gamma 2 (phosphatidylinositol-specific) PLCG2 1,0380644 -1,8093603 -1,3105007 -1,1396219 phospholipid scramblase 1 PLSCR1 1,9751043 1,6298935 1,6971577 2,612559 phosphomannomutase 2 PMM2 1,5163198 1,1936048 1,2667042 1,3510464 phosphoprotein associated with glycosphingolipid microdomains 1 PAG1 -1,1539259 -1,0948491 -1,0586554 1,7527704 phosphoprotein enriched in astrocytes 15 PEA15 1,104181 1,5925672 1,5407782 1,4628495 phosphoribosyl pyrophosphate synthetase 1 PRPS1 1,0931623 1,4708467 1,9635606 1,6603208 phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase PAICS -1,0485244 2,050158 1,6622453 1,4758015 phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase GART 1,4372758 1,5399818 1,2750741 1,5477774 phosphorylase, glycogen; brain PYGB 1,2901249 -1,1007872 1,2112045 1,695468 phosphoserine aminotransferase 1 PSAT1 1,3619817 1,0088812 1,8934586 3,4190857 piccolo (presynaptic cytomatrix protein) PCLO 1,28924 -1,5508288 -2,1183677 -1,9684126 pigeon homolog (Drosophila) PION 1,2295184 1,4641638 1,2714025 1,583149 pigeon homolog (Drosophila) PION 1,1506791 1,2444439 1,4800732 1,5227207 pirin (iron-binding nuclear protein) PIR -1,0112295 -1,7435292 -1,4963598 -1,2498306

PITPNM family member 3 PITPNM3 -1,0246617 -1,3089328 -1,5175537 -1,4699762 pitrilysin metallopeptidase 1 PITRM1 1,2415903 1,6366413 2,108696 2,017893 pituitary tumor-transforming 1 PTTG1 1,0644997 -1,7039654 1,1279075 1,1888785 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 placenta-specific 2 (non-protein coding) PLAC2 -1,3862574 -2,0446072 -1,3836099 -1,6101992 placenta-specific 8 PLAC8 -1,2207819 -1,7672019 -1,797533 -2,0933416 placental growth factor PGF 1,099263 1,537129 1,8290261 1,4243823 plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) PKP1 -1,157496 -1,639798 -1,2299098 -1,242891 plakophilin 2 PKP2 1,235427 2,0892332 2,131285 2,6401763 plasminogen activator, tissue PLAT -1,2709122 3,0787282 4,563853 3,803275 plasminogen activator, urokinase receptor PLAUR 1,1879689 1,5765054 1,7869025 2,3518672 PLGLA|PLGLB2| plasminogen-like A | plasminogen-like B2 | plasminogen | plasminogen-like B1 PLGLB1 -1,0310526 -1,5001268 1,041982 -1,2767357 PLGLB2|PLGLB1 plasminogen-like B2 | plasminogen-like B1 | plasminogen | plasminogen-like A |PLGLA -1,177601 -1,7628273 -1,163438 -1,2637423 PLGLB2|PLGLB1 plasminogen-like B2 | plasminogen-like B1 | plasminogen | plasminogen-like A |PLGLA -1,1676648 -1,7701348 -1,1659259 -1,2552471 pleckstrin 2 PLEK2 -1,0328575 2,5294375 2,6857524 3,673466 pleckstrin homology domain containing, family A member 5 PLEKHA5 1,0779475 1,1870849 1,6597716 1,8564404 pleckstrin homology domain containing, family A member 6 PLEKHA6 1,0218012 -1,161505 -1,64503 -1,9541255 pleckstrin homology domain containing, family A member 7 PLEKHA7 -1,1505859 -3,2357206 -2,9497333 -3,3996081 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 PLEKHG1 1,0349373 -2,0836246 -1,8012252 -1,8257525 pleckstrin homology domain containing, family G (with RhoGef domain) member 3 PLEKHG3 1,2044468 1,2689071 1,4021362 1,5805839 pleckstrin homology domain containing, family O member 2 PLEKHO2 1,5701779 1,1584818 1,0622002 1,3034861 pleckstrin homology-like domain, family A, member 1 PHLDA1 1,2823367 1,551362 1,5333112 2,1428547 pleckstrin homology-like domain, family A, member 3 PHLDA3 -1,6692103 -2,0250998 -1,3412771 -1,2597271 pleckstrin homology-like domain, family B, member 2 PHLDB2 1,100603 1,597866 1,3115472 1,7192181 plexin A2 PLXNA2 1,0515083 -2,374326 -1,7341888 -1,7066878 plexin A3 PLXNA3 -1,2560643 -1,6856265 -1,3137828 -1,2415735 plexin B2 PLXNB2 -1,0819044 -1,5036458 -1,2644973 -1,1315774 plexin domain containing 1 PLXDC1 -1,1041311 1,2327338 2,880269 2,8615847

POC1 centriolar protein homolog A (Chlamydomonas) POC1A 1,1549859 -1,08386 1,0331577 1,5859634 podocalyxin-like PODXL 1,1097364 -1,6102679 -1,6211448 -1,6050509 podoplanin PDPN 1,0264412 1,4244336 1,0626581 1,6301053 poliovirus receptor PVR 1,5333639 1,7547964 1,545665 1,8703243 polo-like kinase 1 PLK1 -1,0981119 -1,9282031 -1,2542055 -1,1305149 polo-like kinase 1 substrate 1 PLK1S1 1,075246 -1,5052937 -1,2941027 -1,263197 polo-like kinase 2 PLK2 1,7280278 1,6697693 1,3311841 1,4493692 polo-like kinase 4 PLK4 -1,110936 -1,5900899 1,0187562 1,1571922 poly (ADP-ribose) polymerase 1 PARP1 1,5994312 1,394298 1,2533749 1,1035163 poly (ADP-ribose) polymerase family, member 12 PARP12 1,186881 1,1143934 1,0085285 1,5514225 poly (ADP-ribose) polymerase family, member 14 PARP14 1,7785656 1,3176632 1,0261896 1,5172306 poly (ADP-ribose) polymerase family, member 9 PARP9 1,3723911 1,3480089 1,193402 1,6591299 poly(A) binding protein interacting protein 1 PAIP1 -1,2477989 1,2227194 1,2889636 1,5968513 LOC728407|LOC poly(ADP-ribose) glycohydrolase pseudogene | PRO1102 100133130 1,1041847 -1,8968134 -1,1522132 1,1198058 polyamine modulated factor 1 binding protein 1 PMFBP1 1,0599279 -1,8591299 -2,558634 -2,8964648 polycystic kidney disease 1 (autosomal dominant) | polycystic kidney disease 1 (autosomal dominant) PKD1|PKD1P1|N pseudogene 1 | nuclear pore complex interacting protein | GPS, PLAT and transmembrane domain-containing PIP|LOC399491| protein | GPS, PLAT and transmembrane domain-containing protein FLJ00285-like | nuclear pore complex- LOC100288332|L interacting protein-like 1-like OC642778 -1,0016553 -1,3995245 -1,53032 -1,275957 polymerase (DNA directed) nu | HAUS augmin-like complex, subunit 3 POLN|HAUS3 1,0729586 -1,5242535 -1,2579318 -1,0548601 polymerase (DNA directed), beta POLB 1,4817919 1,7719458 1,2979742 1,5569035 polymerase (DNA directed), eta POLH -1,0645677 -1,5604035 -1,0827419 1,0007119 polymerase (DNA directed), theta POLQ -1,1096851 -1,5299513 1,0164922 1,5259577 polymerase (RNA) I polypeptide A, 194kDa POLR1A 1,31903 1,5619278 1,1866754 1,1423723 polymerase (RNA) I polypeptide B, 128kDa POLR2J2|UPK3BPOLR1B 1,4969554 1,5200847 1,138099 1,2871903 polymerase (RNA) II (DNA directed) polypeptide J2 | uroplakin 3B-like | polymerase (RNA) II (DNA directed) L|POLR2J3|POL polypeptide J3 | polymerase (RNA) II (DNA directed) polypeptide J4, pseudogene R2J4 -1,1312871 -1,508927 -1,5332545 -1,5518471 polymerase (RNA) II (DNA directed) polypeptide J3 | polymerase (RNA) II (DNA directed) polypeptide J2 | POLR2J3|POLR2 uroplakin 3B-like J2|UPK3BL -1,2073652 -2,1518102 -2,1726162 -1,6987762 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 polymerase (RNA) III (DNA directed) polypeptide G (32kD) POLR3G -1,1014004 1,7547458 1,4086691 1,4347655 polyribonucleotide nucleotidyltransferase 1 PNPT1 1,6823176 1,6345303 1,3048332 1,3510367 post-GPI attachment to proteins 1 PGAP1 -1,1611376 -1,77998 -1,4359225 -1,5734503 postmeiotic segregation increased 2 pseudogene 4 | postmeiotic segregation increased 2 pseudogene 11 | PMS2P4|PMS2P postmeiotic segregation increased 2 pseudogene 3 11|PMS2P3 1,007547 -1,2652514 -1,5211793 -1,4220976 postmeiotic segregation increased 2-like 2 pseudogene | postmeiotic segregation increased 2 pseudogene 3 | PMS2L2|PMS2P postmeiotic segregation increased 2 pseudogene 6 | PMS2 postmeiotic segregation increased 2 (S. 3|PMS2P6|LOC4 cerevisiae)-like | postmeiotic segregation increased 2 pseudogene 1 41259|PMS2P1 1,136072 -1,326996 -1,5206194 -1,4149027 potassium channel tetramerisation domain containing 1 KCTD1 -1,1125628 -2,1605487 -1,7692305 -1,6417818 potassium channel tetramerisation domain containing 11 KCTD11 -1,546837 -1,1973709 -1,438502 -1,1981856 potassium channel, subfamily K, member 1 KCNK1 -1,7270006 -2,0124104 -1,1105003 1,0100764 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 KCNN4 -1,1399052 1,1717067 1,4278591 1,6809481 potassium inwardly-rectifying channel, subfamily J, member 15 KCNJ15 1,1212053 1,4903283 1,6684133 2,4666862 potassium inwardly-rectifying channel, subfamily J, member 2 KCNJ2 2,0034595 3,2002614 1,9292996 1,6443956 potassium voltage-gated channel, KQT-like subfamily, member 2 KCNQ2 -1,036178 1,355263 1,538322 1,5860777 potassium voltage-gated channel, shaker-related subfamily, beta member 2 KCNAB2 1,1416227 1,1017786 -1,2119718 -1,536906 potassium voltage-gated channel, subfamily H (eag-related), member 3 KCNH3 -1,0958976 1,0888042 1,0165933 -1,6092224

POU class 5 homeobox 1B POU5F1B -1,3486011 -1,1240605 -1,5051026 -1,1526299

PQ loop repeat containing 3 PQLC3 -1,0777302 1,010097 1,7595512 1,9324702

PR domain containing 7 PRDM7 -1,2155349 1,0963295 1,0115544 -1,5221364

Prader-Willi/Angelman syndrome-5 | small nucleolar RNA, C/D box 64 PAR5|SNORD64 1,0175127 -1,7423927 -1,2259961 -1,0229833 pre-B-cell leukemia homeobox 1 PBX1 -1,0000192 -1,9230517 -1,9541979 -2,6637995 prefoldin subunit 4 PFDN4 1,1912028 -1,0557125 1,133229 1,5374141 pregnancy-associated plasma protein A, pappalysin 1 | PAPPA antisense RNA (non-protein coding) PAPPA|PAPPAS 1,0198878 1,0512111 1,3713452 1,6408683 premature ovarian failure, 1B POF1B -1,0257765 -1,6524822 -1,3285258 -1,6300195 prenyl (decaprenyl) diphosphate synthase, subunit 1 PDSS1 2,2531817 2,5235205 2,855955 3,1569808 prenylcysteine oxidase 1 PCYOX1 -1,1922879 -1,7380828 1,1075283 -1,0152119 prickle homolog 1 (Drosophila) PRICKLE1 1,1581074 1,0682527 -1,3724134 -1,6967858 prickle homolog 2 (Drosophila) PRICKLE2 -1,0281451 1,0784018 1,497719 1,523075 PRICKLE4|TOM prickle homolog 4 (Drosophila) | translocase of outer mitochondrial membrane 6 homolog (yeast) M6 -1,0913821 -1,5836393 -1,2854931 -1,1548488 primase, DNA, polypeptide 1 (49kDa) PRIM1 -1,0977468 -1,5822597 1,0055223 -1,1346539 prion protein PRNP 1,2898265 1,6445136 1,8517793 2,1593678

PRO1102 LOC100133130 1,0467473 -2,0162091 -1,1887587 1,2721192

PRO1102 LOC100133130 1,0379118 -2,0366108 -1,1935654 1,2857285 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 PLOD2 -1,3253269 -1,1300147 1,1429259 1,672703 progestagen-associated endometrial protein PAEP -1,0534211 1,0911978 1,1848925 1,6400821 progestin and adipoQ receptor family member VII PAQR7 -1,3575683 -2,267083 -1,803521 -1,8279285 programmed cell death 11 PDCD11 1,4094771 1,5550578 1,1551653 1,320116 programmed cell death 4 (neoplastic transformation inhibitor) PDCD4 1,1383588 -1,882575 -1,7092632 -1,6211244 proline dehydrogenase (oxidase) 1 PRODH -1,1507472 -2,8477168 -2,3414104 -2,1496584 proline rich 11 PRR11 -1,1748023 -1,8593585 1,1915127 1,5320413 proline rich 15-like PRR15L -1,8856713 -3,3179536 -2,38009 -3,2067604 prolyl 4-hydroxylase, alpha polypeptide I P4HA1 -2,5196116 -1,4976631 -1,1893038 -1,009865 prolyl 4-hydroxylase, alpha polypeptide II P4HA2 -1,6357328 -1,5885965 -1,0342555 1,0425515 prominin 2 PROM2 -1,0432802 -1,6235867 -2,0120258 -1,6832598 propionyl CoA carboxylase, alpha polypeptide PCCA 1,4605832 -1,3344026 -1,4578683 -1,5020126 proprotein convertase subtilisin/kexin type 5 PCSK5 -1,1056309 -1,7092044 -1,9409119 -2,649135 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 prosaposin-like 1 (gene/pseudogene) PSAPL1 -1,1233537 1,2733079 1,6607851 1,0879538 prostaglandin E synthase PTGES 1,1613503 1,1131903 -1,4452114 -1,9678636 prostaglandin reductase 1 PTGR1 1,3001099 1,8737836 2,0375903 2,17281 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) PTGS1 -1,4729546 -1,7008455 1,2307011 1,4141659 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) PTGS2 1,9192538 9,622525 4,8832717 7,767228 protease, serine, 23 PRSS23 1,1067339 1,5393361 2,2528527 1,8360806 protease, serine, 8 PRSS8 -1,4191037 -2,1983335 -1,0235264 1,0611541 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) PSME2 1,4361233 1,8422256 1,1590601 1,20836 proteasome (prosome, macropain) assembly chaperone 1 PSMG1 1,1048411 1,2896951 1,6559194 1,5072173 proteasome (prosome, macropain) subunit, beta type, 7 PSMB7 1,0685028 -1,1444576 1,1220016 1,7373614 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) PSMB9 1,7246476 1,6597102 -1,4536121 -1,4590812 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) PSMB9 1,7240378 1,657342 -1,4501723 -1,4649969 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) PSMB9 1,7240275 1,6622332 -1,4513798 -1,4633795 protein associated with topoisomerase II homolog 2 (yeast) PATL2 1,2947196 -1,0964947 -1,5985581 -1,6233146 protein C (inactivator of coagulation factors Va and VIIIa) PROC -1,0554888 -2,5102835 -2,0641065 -1,6876307 protein C receptor, endothelial PROCR 1,0237873 1,3728825 2,1022382 2,7511618 protein disulfide isomerase family A, member 4 PDIA4 1,1309462 1,2812064 1,7818854 1,214796 protein disulfide isomerase family A, member 5 PDIA5 1,4639983 1,5455537 1,7079141 1,5991616 protein disulfide isomerase family A, member 6 PDIA6 1,1108139 1,2979158 1,5227126 1,1886986 protein inhibitor of activated STAT, 3 PIAS3 -1,0667863 -1,4257048 -1,7496554 -1,9692762 protein kinase C, delta PRKCD -1,1739907 -1,5555378 -1,6518137 -1,5039152 protein kinase C, delta binding protein PRKCDBP -1,2569177 -1,7127717 -1,016641 1,1854993 protein kinase C, eta PRKCH 1,1730129 1,2958618 1,5979929 1,5948069 protein kinase C, theta PRKCQ 1,0559205 1,454393 1,9034171 2,1626527 protein kinase C, zeta PRKCZ -1,1366922 -1,5045859 -1,2057381 -1,2318968 protein kinase, AMP-activated, beta 2 non-catalytic subunit PRKAB2 -1,1542723 -1,6896822 -1,4437591 -1,4875754 protein kinase, X-linked PRKX -1,0554477 -1,9313744 -1,475579 -1,7323556 protein phosphatase 1, regulatory (inhibitor) subunit 12B PPP1R12B 1,2101486 -1,5507847 -1,730966 -1,6515048 protein phosphatase 1, regulatory (inhibitor) subunit 13B PPP1R13B -1,1601211 -1,9762836 -1,2207271 -1,4644943 protein phosphatase 1, regulatory (inhibitor) subunit 1B PPP1R1B -1,0882944 1,0690842 1,7304345 1,8126866 protein phosphatase 1, regulatory (inhibitor) subunit 3B PPP1R3B 1,3127619 1,5652658 1,2562191 1,2432574 protein phosphatase 2, regulatory subunit B, beta PPP2R2B 1,2607714 -1,3133066 -1,6984826 -1,8938998 protein phosphatase 2, regulatory subunit B', alpha PPP2R5A -1,0748714 -1,5757422 1,0390241 1,2150811 protein phosphatase 2, regulatory subunit B'', alpha PPP2R3A -1,13703 -2,0449896 -1,2743348 -1,1082581 protein phosphatase 4, regulatory subunit 1 PPP4R1 1,3019193 1,5792158 1,690917 2,1970065 protein phosphatase 4, regulatory subunit 4 PPP4R4 1,0349777 1,4764918 1,1687512 3,1091123 protein phosphatase, Mg2+/Mn2+ dependent, 1L PPM1L 1,0894331 -1,483708 -1,6962072 -2,0363886 protein regulator of cytokinesis 1 PRC1 -1,0065904 -1,6782013 1,0932779 1,4914134 protein S (alpha) PROS1 -1,0754514 1,2218561 1,6859709 1,6155722 protein S (alpha) PROS1 -1,0320455 1,0292327 1,3681064 1,624526 protein tyrosine phosphatase type IVA, member 1 PTP4A1 1,0629838 1,5864468 1,9935323 2,0769017 protein tyrosine phosphatase, non-receptor type 12 PTPN12 1,3238839 1,5484031 1,3396552 1,8296125 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) PTPN13 -1,0449733 -1,8141646 -1,5763372 -1,8029339 protein tyrosine phosphatase, non-receptor type 2 PTPN2 -1,015059 1,1759197 1,6156288 1,5955287 PTPN20A|PTPN protein tyrosine phosphatase, non-receptor type 20A | protein tyrosine phosphatase, non-receptor type 20B 20B 1,2212884 -1,5206516 -1,4654671 -1,2953364 protein tyrosine phosphatase, receptor type, E PTPRE 1,1372495 1,2296026 1,4080738 1,5541493 protein tyrosine phosphatase, receptor type, G PTPRG 1,1508278 1,1884224 1,1559964 1,5426253 protein tyrosine phosphatase, receptor type, S PTPRS -1,0821297 -1,5609791 -1,5125571 -1,5367532 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 PTPRZ1 1,5196657 -1,423594 1,0411345 -1,1285781 proteolipid protein 2 (colonic epithelium-enriched) | prickle homolog 3 (Drosophila) PLP2|PRICKLE3 1,0528576 -1,0437541 1,4612172 1,5060999 protocadherin beta 10 PCDHB10 1,2073216 1,2234645 1,7245553 1,6465895 protocadherin beta 11 PCDHB11 1,1995689 1,3624121 1,9639643 2,4492245 protocadherin beta 12 PCDHB12 1,3033737 1,5531982 2,1967022 2,1869237 protocadherin beta 13 PCDHB13 1,5991256 1,2830659 1,9231216 1,9344378 protocadherin beta 14 PCDHB14 1,4962441 1,3750519 1,8086792 1,6305023 protocadherin beta 15 PCDHB15 1,910045 1,3339382 1,6326697 2,0586267 protocadherin beta 16 PCDHB16 1,1101176 1,1103499 1,3707057 1,5868448 protocadherin beta 18 pseudogene PCDHB18 1,5852716 1,2242185 1,6666392 1,8954034 protocadherin beta 2 PCDHB2 -1,0346692 -1,0433681 -1,0787519 -1,5406426 protocadherin beta 8 PCDHB8 1,0611702 1,3496579 1,6614659 1,8972667 protocadherin beta 9 PCDHB9 1,061453 1,3026171 1,5166596 1,5283906 pseudouridylate synthase 10 PUS10 1,0903319 1,0202 1,3766276 1,53337 pseudouridylate synthase 3 PUS3 1,3590777 1,3825585 1,6210623 1,5647298 pseudouridylate synthase 7 homolog (S. cerevisiae) PUS7 1,3652759 1,9117306 1,2113142 1,5529821 psoriasis susceptibility 1 candidate 3 (non-protein coding) PSORS1C3 -1,4605552 -2,6187959 -2,8972566 -2,2601616 psoriasis susceptibility 1 candidate 3 (non-protein coding) PSORS1C3 -1,4488046 -2,635134 -2,9024544 -2,2631922

PTEN induced putative kinase 1 PINK1 -1,060141 -1,9232881 -1,2840998 -1,0722493

PTPRF interacting protein, binding protein 2 (liprin beta 2) PPFIBP2 -1,0687323 -3,4598398 -2,3012395 -2,7222939 purine nucleoside phosphorylase PNP 1,5841088 3,0588076 3,4439752 5,857199 purinergic receptor P2X, ligand-gated ion channel, 7 P2RX7 -1,169523 -1,4737157 1,5698661 2,3421698 purinergic receptor P2Y, G-protein coupled, 1 P2RY1 1,1581503 1,5855609 1,8271234 1,7822523 purinergic receptor P2Y, G-protein coupled, 2 P2RY2 1,0232356 -1,186797 -1,4371403 -1,665643 putative ubiquitin-like protein FUBI-like protein ENSP00000310146-like LOC100291851 -1,5311123 1,1860037 1,4350481 1,5763845

PYD and CARD domain containing PYCARD -1,0653565 -1,694268 -1,188093 1,017209 pyridoxal-dependent decarboxylase domain containing 2, pseudogene PDXDC2P 1,1091197 -1,4380014 -1,5439571 -1,5075421 pyrimidinergic receptor P2Y, G-protein coupled, 6 P2RY6 2,0309534 2,3197904 2,4689896 1,9744692 pyrophosphatase (inorganic) 1 PPA1 1,3145468 1,5944875 1,4660693 1,7144697 pyruvate carboxylase PC -1,0439836 1,1166307 1,6257954 1,279965 pyruvate dehydrogenase kinase, isozyme 1 PDK1 -2,3586257 -1,3188279 1,1669344 1,0564501 pyruvate dehydrogenase kinase, isozyme 2 PDK2 -1,0110236 -2,1642923 -1,1524737 -1,0951879 pyruvate dehydrogenase kinase, isozyme 3 PDK3 -1,5759271 -1,2852216 -1,3362731 -1,1903243 pyruvate dehyrogenase phosphatase catalytic subunit 1 PDP1 1,5943832 1,4483626 1,1858834 1,3095399 QSOX1|FLJ2386 quiescin Q6 sulfhydryl oxidase 1 | hypothetical protein FLJ23867 7 -1,8823074 -1,4676819 -1,3602371 -1,4387234

RAB GTPase activating protein 1 RABGAP1 -1,0997682 -1,6207848 -1,2046626 -1,2723479

RAB GTPase activating protein 1-like RABGAP1L 1,0963497 -1,7494986 -1,2702738 -1,3098745

RAB7, member RAS oncogene family-like 1 RAB7L1 1,4534627 1,6929845 2,0593617 2,0650065

RAD51-like 1 (S. cerevisiae) RAD51L1 1,0188316 -1,5269763 -1,4710621 -1,3292453 radical S-adenosyl methionine domain containing 2 RSAD2 1,0333663 -1,1962534 3,0112371 3,273128

Ral GEF with PH domain and SH3 binding motif 1 RALGPS1 1,0208324 -2,0267577 -1,5092862 -1,6421335

Ral GEF with PH domain and SH3 binding motif 2 RALGPS2 -1,0034765 -2,135753 -1,6162708 -1,4316305 ral guanine nucleotide dissociation stimulator-like 2 RGL2 -1,3308023 -1,7448314 -1,084946 1,0040743 ral guanine nucleotide dissociation stimulator-like 2 RGL2 -1,3262234 -1,7569791 -1,0645758 1,0161728 ral guanine nucleotide dissociation stimulator-like 2 RGL2 -1,3270591 -1,7596768 -1,0680557 1,0176476

RAN binding protein 1 RANBP1 1,5331597 1,2869543 1,1131374 1,2716045

Rap guanine nucleotide exchange factor (GEF) 3 RAPGEF3 1,1249373 1,5525911 1,4744256 1,5247195

Rap guanine nucleotide exchange factor (GEF) 3 RAPGEF3 -1,0762963 1,5075312 1,0250424 1,0070745 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31

Rap guanine nucleotide exchange factor (GEF) 4 RAPGEF4 1,356899 1,7598966 1,3411982 1,1688645

Rap guanine nucleotide exchange factor (GEF)-like 1 RAPGEFL1 -1,1214262 -3,94948 -2,384352 -2,333959

RAP1 GTPase activating protein 2 RAP1GAP2 -1,0356778 1,6307082 1,5138035 1,4552542

RAR-related orphan receptor C | leucine rich repeat and Ig domain containing 4 RORC|LINGO4 -1,0766916 1,3496437 1,5233564 1,3387287

RAS and EF-hand domain containing RASEF -1,1929944 -1,9814093 -1,3482834 -1,4028993

Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 RASSF10 -1,0457711 -1,3814563 -1,91016 -1,6277605

Ras association (RalGDS/AF-6) domain family member 2 RASSF2 -1,5913692 -1,1278483 -1,0027418 -1,1735512

Ras association (RalGDS/AF-6) domain family member 5 RASSF5 -1,2580425 -1,6176538 1,0044222 1,1059408

Ras association (RalGDS/AF-6) domain family member 6 RASSF6 -1,0278223 -2,5788329 -1,689359 -1,8972204

RAS guanyl releasing protein 1 (calcium and DAG-regulated) RASGRP1 1,0161691 5,007083 4,709948 6,4857407 ras homolog gene family, member D RHOD -1,2549169 -1,5997114 -1,0865545 -1,0288583

RAS p21 protein activator 4 RASA4 -1,3307294 -2,8357031 -2,385078 -2,2553253 RASA4|RASA4P| RAS p21 protein activator 4 | RAS p21 protein activator 4 pseudogene | RAS p21 protein activator 4B RASA4B -1,2964315 -1,9177048 -1,6850644 -1,6946836 RASA4|RASA4P| RAS p21 protein activator 4 | RAS p21 protein activator 4 pseudogene | RAS p21 protein activator 4B RASA4B -1,3203024 -2,3399615 -1,8625667 -1,7913725 RASA4|RASA4P| RAS p21 protein activator 4 | RAS p21 protein activator 4 pseudogene | RAS p21 protein activator 4B RASA4B -1,34506 -2,3433886 -1,6846479 -1,6940328 ras responsive element binding protein 1 RREB1 -1,0844219 1,5769073 1,7787467 1,6580346 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) RAC2 -1,0771874 1,0313144 1,1384236 1,5916705

Ras-related GTP binding C RRAGC 1,401816 1,1862472 1,3809061 1,5145271

RCAN family member 3 RCAN3 -1,4570003 -2,1828935 -1,0026463 -1,0447888 receptor accessory protein 1 REEP1 1,3417099 1,5281188 2,5854146 2,0807128 receptor accessory protein 4 REEP4 -1,2306352 -1,9135165 -1,1602453 -1,0495507 receptor-interacting serine-threonine kinase 3 RIPK3 1,7591105 1,0885308 1,0843638 -1,0119613 receptor-interacting serine-threonine kinase 4 RIPK4 -1,6928765 -2,1220376 -2,4811099 -2,7967963 reelin RELN -1,1292157 1,1475879 1,9428959 4,697945 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 RCBTB1 2,4035125 1,8040975 2,0002115 2,2257316 regulator of G-protein signaling 6 RGS6 -1,0059232 1,0791056 -1,5008296 -1,3154383 replication factor C (activator 1) 1, 145kDa RFC1 -1,1756297 1,3541669 -1,0177909 2,2401705 required for meiotic nuclear division 5 homolog A (S. cerevisiae) RMND5A -1,0592479 -1,7593151 -1,1981083 -1,1600996

REST corepressor 2 RCOR2 -1,6921325 1,1205059 -1,1602453 -1,2338723

REST corepressor 3 RCOR3 -1,0956256 -1,530313 -1,3326721 -1,4322287 reticulocalbin 1, EF-hand calcium binding domain RCN1 1,1303864 1,457769 1,4175483 1,5621332 reticulon 4 interacting protein 1 RTN4IP1 1,2490889 -1,2766134 -1,5055659 -1,4443179 retinoblastoma 1 RB1 1,121341 1,2020018 1,3906502 1,5230025 retinoblastoma binding protein 8 RBBP8 1,1181796 1,83918 1,3682063 1,4388028 retinoic acid early transcript 1E RAET1E -1,2621535 -1,5087584 -1,7011518 -1,2255906 retinoic acid early transcript 1L RAET1L 1,028591 -1,0018129 -1,6523254 -2,097283 retinoic acid induced 14 RAI14 -1,0786763 1,1579597 1,0961573 1,7218817 retinoic acid receptor responder (tazarotene induced) 3 RARRES3 1,4764445 1,1400634 -1,5703497 -1,2296277 RARB|LOC10013 retinoic acid receptor, beta | hypothetical protein LOC100130354 0354 1,0105425 -1,3050346 -1,6014354 -1,3056455 retinoic acid receptor, gamma RARG -1,150627 -1,6219476 -1,5186013 -1,3247856 retinoid X receptor, alpha RXRA -1,0777515 -2,096644 -1,5702604 -1,4413655 retinol dehydrogenase 10 (all-trans) RDH10 1,2563355 -1,5091743 -1,279814 -1,4887027 retinol saturase (all-trans-retinol 13,14-reductase) RETSAT -1,1422205 -2,0390482 -1,0539738 -1,0715677

REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 1 REXO1L1 -1,1002448 1,3219775 -1,0790868 -1,5020865

REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 1 REXO1L1 -1,101551 1,325542 -1,083436 -1,5032661

REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 1 REXO1L1 -1,1019447 1,3180496 -1,0784575 -1,503863

REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 1 REXO1L1 -1,1033219 1,3185811 -1,0757593 -1,504464

Rho GTPase activating protein 11A ARHGAP11A 1,0058473 -1,8344567 1,1421374 1,6402713 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31

Rho GTPase activating protein 12 ARHGAP12 -1,0024568 -1,6210612 -1,0823673 1,0754002

Rho GTPase activating protein 21 ARHGAP21 1,012058 -1,5611092 -1,0653023 1,0602868

Rho GTPase activating protein 23 ARHGAP23 1,1276414 -1,0888503 -1,5450639 -1,700484

Rho GTPase activating protein 25 ARHGAP25 1,4126583 1,3018061 1,6553329 1,5439153

Rho GTPase activating protein 26 ARHGAP26 1,1266154 -1,3051511 -1,5352083 -1,7980429

Rho GTPase activating protein 29 ARHGAP29 -1,0105946 -1,8133662 -1,3568479 -1,2829956

Rho GTPase activating protein 42 ARHGAP42 1,0346911 -2,167165 -2,0294538 -2,071978

Rho guanine nucleotide exchange factor (GEF) 26 ARHGEF26 1,1342914 -1,2250402 -1,2822498 -1,503364

Rho guanine nucleotide exchange factor (GEF) 37 ARHGEF37 -1,1304865 -1,5281845 -1,8284005 -1,7730461

Rho guanine nucleotide exchange factor (GEF) 4 ARHGEF4 1,1430641 -1,7389953 -1,2014472 -1,0811716

Rho-related BTB domain containing 3 RHOBTB3 1,1002655 -1,8666947 -2,0324383 -1,679078 rhomboid, veinlet-like 2 (Drosophila) RHBDL2 -1,2854298 -1,5149713 -1,5142003 -1,2767851 rhophilin, Rho GTPase binding protein 2 RHPN2 -1,4177344 -1,3216829 -1,3192189 -1,5456574 rhotekin 2 RTKN2 -1,2033848 -1,9966059 -1,3806639 -1,2195991 riboflavin kinase RFK 1,2541225 1,5537657 1,3282088 1,1978898 ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) RNASEL 1,2825787 -1,6274819 -1,4574164 -1,542011 ribonuclease, RNase A family, 1 (pancreatic) RNASE1 -1,1434643 1,319703 -1,0877844 -1,5688561 ribonucleoprotein, PTB-binding 2 RAVER2 -1,0006533 -1,7376422 -1,1297739 -1,3235894 ribonucleotide reductase M2 RRM2 1,1282294 -1,0532568 -1,0206431 1,5732236 ribonucleotide reductase M2 B (TP53 inducible) RRM2B 1,0956886 1,1857572 1,8197033 1,9689989 ribosomal L24 domain containing 1 RSL24D1 1,1811181 -1,0912064 1,2926526 1,6293199 ribosomal modification protein rimK-like family member B RIMKLB 1,2967058 1,2279053 1,6019039 1,6258265 ribosomal protein L10 RPL10 -1,0214885 -1,0268321 1,2115289 1,9356855 RPL21|RPL21P2 ribosomal protein L21 | ribosomal protein L21 pseudogene 28 8 -1,0242676 -1,1016861 1,1396953 1,6538442 ribosomal protein L22-like 1 RPL22L1 1,1192548 1,5138365 1,9462463 2,545219 ribosomal protein S6 kinase, 90kDa, polypeptide 5 RPS6KA5 1,1895893 -1,7795941 -1,1050406 1,0302163 ribosomal protein SA pseudogene 52 RPSAP52 1,0913583 -1,1864401 1,3161728 1,5379579 ribosomal protein SA pseudogene 58 RPSAP58 1,0837877 -1,6307379 -1,5053798 -1,2758456 ribosomal RNA processing 12 homolog (S. cerevisiae) RRP12 1,1063137 1,9803082 1,5212598 1,4469291 ribosome production factor 2 homolog (S. cerevisiae) RPF2 1,2545023 1,826111 1,377063 1,4600016 ribosome production factor 2 homolog (S. cerevisiae) RPF2 1,3614794 1,5458556 1,3323454 1,5753242 ring finger protein 125 RNF125 1,3332876 1,8788639 2,3713968 2,6430252 ring finger protein 128 RNF128 1,1530353 -1,7777652 -1,3128908 -1,5265858 ring finger protein 141 RNF141 -1,0554763 -1,5242696 -1,5453775 -1,4315557 ring finger protein 152 RNF152 -1,3313462 -2,1769621 -3,8250792 -3,4531782 ring finger protein 185 RNF185 1,1190151 -1,5534303 -1,0875267 1,2152008 ring finger protein 207 RNF207 1,0825486 -1,02423 -1,5192052 -1,5135038 ring finger protein 39 RNF39 -1,5032651 -1,6931103 -2,0177765 -2,2423987 ring finger protein 39 RNF39 -1,5040499 -1,697271 -2,0134835 -2,237335 ring finger protein 43 RNF43 -1,342432 -1,9532106 -1,5337948 -1,4071484

RIO kinase 1 (yeast) RIOK1 1,5356452 1,2189076 1,4370948 1,4915361

RNA binding motif protein 41 RBM41 1,0247006 -1,5604953 -1,0904367 -1,0073242

RNA binding motif protein 7 RBM7 1,1389396 1,1230664 1,6962184 1,6832582

RNA binding protein with multiple splicing RBPMS -1,01854 -1,4171118 -1,714107 -1,4305493

RNA binding protein, fox-1 homolog (C. elegans) 2 RBFOX2 1,0553905 -1,5436796 -1,3427981 -1,2690057

RNA-binding region (RNP1, RRM) containing 3 RNPC3 1,2120311 -1,7202094 -1,405679 -1,913201

RNA, U4 small nuclear 2 RNU4-2 -1,1203011 -1,2387685 -1,5288277 1,0912509

RNA, U5A small nuclear RNU5A 1,1073436 -1,6881394 1,1838567 1,2999045 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 rogdi homolog (Drosophila) ROGDI 1,143383 -1,4625295 -1,8497143 -1,6520267 RUNDC2C|RUN RUN domain containing 2C | RUN domain containing 2A | RUN domain containing 2B DC2A|RUNDC2B 1,0889975 -1,6162136 -1,041077 1,190615

RUN domain containing 3A RUNDC3A 1,3228346 1,4673802 3,19161 1,9319515

RuvB-like 1 (E. coli) RUVBL1 1,6956819 1,833676 1,4256121 1,4897255

S1 RNA binding domain 1 SRBD1 1,1721746 -1,0057759 1,5071944 1,3454975

S100 calcium binding protein A10 S100A10 -1,0773675 1,2306498 1,6441549 1,4832736

S100 calcium binding protein A12 S100A12 1,3855076 3,6282308 7,9020076 11,238406

S100 calcium binding protein A14 S100A14 -1,1778373 -1,9514148 -1,7370192 -1,6686449

S100 calcium binding protein A7 S100A7 1,1481285 1,4571183 2,4329967 4,4923577

S100 calcium binding protein A7A S100A7A 1,1770204 1,7987252 3,2261364 6,3209963

S100 calcium binding protein A8 S100A8 1,6394469 3,2811682 3,0490932 3,3286467

S100 calcium binding protein A9 S100A9 1,9018607 6,905644 11,61708 12,724798 saccharopine dehydrogenase (putative) SCCPDH 1,0932527 1,1461837 1,8114216 1,4840729

Sad1 and UNC84 domain containing 1 SUN1 -1,1019739 -1,6560968 -1,3909122 -1,4498599 sal-like 4 (Drosophila) SALL4 -1,0327272 1,2604373 -1,1831338 -1,5488746 salt-inducible kinase 1 SIK1 -1,649627 -1,8851608 -1,5867782 -1,5061975 salt-inducible kinase 2 SIK2 -1,1560339 -1,5274822 -1,0498213 -1,0299416 salvador homolog 1 (Drosophila) SAV1 1,2761282 1,7661538 1,7913454 1,7994299 SAMHD1|C20orf SAM domain and HD domain 1 | chromosome 20 open reading frame 118 118 1,9794751 1,1238195 1,14711 1,5840015 scavenger receptor class A, member 3 SCARA3 1,1083449 -1,7083607 -1,9993523 -2,251169 schlafen family member 11 SLFN11 1,2769957 1,2832712 1,7915982 1,6315601 schlafen family member 5 SLFN5 1,3529778 1,5724978 1,4070884 1,5335048 schwannomin interacting protein 1 | IQ motif containing J-schwannomin interacting protein 1 read-through SCHIP1|IQCJ- transcript SCHIP1 1,5145892 1,301096 1,5121093 1,3931897 sciellin SCEL -1,7047553 -3,9332836 -2,965802 -3,3666878

SCL/TAL1 interrupting locus STIL -1,0776945 -1,6765459 -1,0751582 1,0714234

Scm-like with four mbt domains 2 SFMBT2 1,0512171 1,1212624 1,6545293 1,5779599

SCY1-like 3 (S. cerevisiae) | chromosome 1 open reading frame 112 SCYL3|C1orf112 1,0170662 -1,70571 -1,1955965 1,1787392

SEC31 homolog B (S. cerevisiae) SEC31B 1,0351282 -1,1270616 -1,638624 -1,3316308

Sec61 alpha 2 subunit (S. cerevisiae) SEC61A2 -1,1216561 -1,504041 -1,266099 -1,2032074 secreted and transmembrane 1 SECTM1 1,3883282 1,8835559 1,5858921 1,7231867 secreted phosphoprotein 1 SPP1 -1,0902514 1,0459744 3,7428992 15,807698 secretoglobin, family 1A, member 1 (uteroglobin) SCGB1A1 -1,2611299 -1,6440734 -5,779944 -6,118845 sel-1 suppressor of lin-12-like 3 (C. elegans) SEL1L3 1,155436 1,0897533 2,7197416 4,5427327 selenium binding protein 1 SELENBP1 1,2049756 -1,1273884 -1,6073172 -1,8329451 selenoprotein X, 1 SEPX1 1,3722978 1,0860274 1,440535 1,5278113 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A SEMA3A 1,2943978 -1,5432658 -1,5868096 -1,7011586 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C SEMA3C 1,1064417 -3,7499027 -2,666696 -2,3140914 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D SEMA3D 1,4617828 -1,5735362 -1,9450535 -1,6505443 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F SEMA3F -1,2697852 -2,0108585 -1,4418896 -1,82466 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B SEMA4B 1,007507 1,5201219 2,0993621 2,523177 sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A SEMA5A -1,0335584 -2,3677502 -2,1280863 -2,3163986 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D SEMA6D -1,2269487 -5,1792684 -3,8500588 -5,387721 septin 12 41164 -1,0670681 1,1366978 -1,0273638 -1,5760319 sequestosome 1 SQSTM1 -1,0168205 -1,9815999 -1,3558679 -1,0504259 serine carboxypeptidase 1 SCPEP1 1,1047411 -1,5357001 -1,9199067 -1,9017783 serine hydroxymethyltransferase 1 (soluble) SHMT1 -1,112108 -1,5296293 -1,0366418 -1,1479493 serine hydroxymethyltransferase 2 (mitochondrial) SHMT2 1,0086099 -1,1308289 1,2600598 2,019469 serine palmitoyltransferase, long chain base subunit 3 SPTLC3 1,6217085 -1,8008579 -2,2018101 -2,8719428 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 serine peptidase inhibitor, Kazal type 5 SPINK5 1,1175145 1,5089489 1,267763 1,324726 serine threonine kinase 39 STK39 1,0359256 -1,0971766 -1,4668546 -1,7267603 serine/arginine-rich splicing factor 7 SRSF7 1,4081957 1,6114829 1,0793328 1,0415238 serine/threonine kinase 17a STK17A 1,1613195 1,2403802 1,3597822 1,722197 serine/threonine kinase 38 STK38 -1,0206212 -1,6810437 -1,511098 -1,6796186 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 SERPINA1 1,0790322 1,3643101 5,7915955 27,56439 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 SERPINA3 1,9243844 16,495953 71,25668 57,039803 serpin peptidase inhibitor, clade B (ovalbumin), member 1 SERPINB1 1,9777852 5,048833 6,211752 9,116376 serpin peptidase inhibitor, clade B (ovalbumin), member 10 SERPINB10 -1,3385792 -1,6997153 -1,8598293 -3,001167 serpin peptidase inhibitor, clade B (ovalbumin), member 12 SERPINB12 -1,7444648 1,1003299 1,1185399 -1,0483663 serpin peptidase inhibitor, clade B (ovalbumin), member 13 SERPINB13 1,1360916 1,5428165 1,5018358 1,3805174 serpin peptidase inhibitor, clade B (ovalbumin), member 2 SERPINB2 -1,314142 1,6572554 1,0877683 1,0576555 serpin peptidase inhibitor, clade B (ovalbumin), member 3 SERPINB3 1,9048659 2,9286692 4,343102 5,750625 serpin peptidase inhibitor, clade B (ovalbumin), member 4 | serpin peptidase inhibitor, clade B (ovalbumin), SERPINB4|SER member 3 PINB3 2,1076384 3,1961315 5,137087 6,88755 serpin peptidase inhibitor, clade B (ovalbumin), member 7 SERPINB7 -1,0632564 2,0157506 1,7885789 -1,4933898 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 SERPINE1 -1,4838022 -1,2761599 1,1861868 1,5865611 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 SERPINE2 -1,0662752 1,1671478 2,1904025 4,331616 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 SERPING1 -1,0877496 -1,0087692 1,2388594 1,6492056 serum amyloid A2 SAA2 1,0963287 1,6028032 1,408995 1,1482632 serum response factor binding protein 1 SRFBP1 1,4505463 1,6443233 1,3753064 1,4008898 serum/glucocorticoid regulated kinase 1 SGK1 2,2054904 1,8307873 2,105415 2,5250607 serum/glucocorticoid regulated kinase family, member 3 | chromosome 8 open reading frame 44 SGK3|C8orf44 1,2812208 -1,5194076 -1,0960251 -1,1977813 sestrin 3 SESN3 1,0831614 -1,5012606 -1,002492 -1,3712101

SET binding protein 1 SETBP1 1,163351 1,896359 1,419161 1,4264958 sex comb on midleg-like 1 (Drosophila) SCML1 1,4418591 -1,211518 1,4625576 2,0916169

SFT2 domain containing 1 SFT2D1 1,081104 1,1306673 1,4352051 1,7212178

SH2 domain containing 3C SH2D3C -1,1723319 -1,6550779 -1,1246771 -1,1238893

SH2B adaptor protein 1 SH2B1 1,1089569 -1,107963 -1,5549529 -1,4237845

SH3 and cysteine rich domain STAC -1,5420737 -1,6982346 -1,2308894 -1,1042069

SH3 domain and tetratricopeptide repeats 2 SH3TC2 1,2433704 1,6659254 1,4623395 2,4547808

SH3 domain containing 19 SH3D19 -1,019905 -1,515174 -1,156134 -1,0073025

SH3 domain containing ring finger 2 SH3RF2 1,3297014 1,5912592 1,2459239 1,1294392

SH3-domain GRB2-like endophilin B2 SH3GLB2 -1,1218629 -1,622443 -1,7573961 -1,6502743

SHC (Src homology 2 domain containing) transforming protein 1 SHC1 1,1302615 1,453443 1,5334247 1,7024298

SHC SH2-domain binding protein 1 SHCBP1 1,0102116 -1,2134845 1,2018882 1,6604366 shisa homolog 5 (Xenopus laevis) SHISA5 1,2636683 1,99407 1,6955541 1,8069596 short chain dehydrogenase/reductase family 16C, member 5 SDR16C5 1,611966 4,0603676 4,610957 5,942375 shugoshin-like 1 (S. pombe) SGOL1 1,0173846 -1,5699407 -1,0149969 1,2433138 shugoshin-like 2 (S. pombe) SGOL2 1,1930097 -1,7927935 1,1048459 1,4507812 sialic acid binding Ig-like lectin 5 SIGLEC5 -1,250731 1,524268 1,061698 -1,1647861 sialidase 1 (lysosomal sialidase) NEU1 -1,1553738 -2,0044339 1,1664481 1,1210423 sialidase 1 (lysosomal sialidase) NEU1 -1,1549776 -2,0098464 1,1689838 1,1215338 sialidase 1 (lysosomal sialidase) NEU1 -1,2381749 -2,05931 1,094984 1,1552227 sideroflexin 1 SFXN1 1,0806729 1,2743318 1,1482108 1,5236087 sideroflexin 4 SFXN4 1,5831965 1,201645 -1,2005506 -1,0664666 sideroflexin 5 SFXN5 1,2206585 1,1666301 2,0113583 2,2002692 signal transducer and activator of transcription 1, 91kDa STAT1 1,5678105 1,6996446 1,2961916 1,7457031 signal transducer and activator of transcription 3 (acute-phase response factor) STAT3 1,2811158 1,5900763 1,2469711 1,4843123 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 signal-induced proliferation-associated 1 | EH domain binding protein 1-like 1 SIPA1|EHBP1L1 -1,0027709 1,5493441 1,4632282 1,5284857 similar to hCG1645603 LOC732275 -1,4498857 -1,2050719 1,0822492 -1,5205209 similar to hCG1750329 LOC100129890 -1,2221267 1,1693498 -1,096112 -1,6272355 similar to nucleolar protein family A, member 3 LOC100289143 -1,0089703 1,5581272 1,1669561 1,2617269 single stranded DNA binding protein 3 SSBP3 -1,1699603 -2,4760258 -1,5208557 -1,6165967

SIX homeobox 1 SIX1 -1,3217577 1,3262581 1,1995404 1,6129173 six transmembrane epithelial antigen of the prostate 1 STEAP1 1,0088313 1,1645771 1,1302657 1,756608 slingshot homolog 1 (Drosophila) SSH1 1,1456949 1,3058044 1,4030703 1,7728058 slingshot homolog 3 (Drosophila) SSH3 -1,144363 -1,5040255 -1,1562899 -1,0667335

SLIT and NTRK-like family, member 6 SLITRK6 -1,6011147 -3,6439047 -1,7620798 -1,6456238 slit homolog 2 (Drosophila) SLIT2 1,0474027 -1,1276802 1,0611955 1,7425913

SLIT-ROBO Rho GTPase activating protein 1 SRGAP1 1,3447585 -1,2817087 -1,6197565 -1,4651489

SLIT-ROBO Rho GTPase activating protein 2 SRGAP2 -1,0039873 -1,5537235 -1,0078673 -1,0704844

SMAD family member 1 SMAD1 1,4978027 1,3244642 1,3460953 1,2493507

SMAD specific E3 ubiquitin protein ligase 1 SMURF1 -1,1393646 -1,6159065 -1,3092638 -1,1677876 small Cajal body-specific RNA 9 SCARNA9 -1,0425929 -1,6444157 -1,4958644 1,3837681 small Cajal body-specific RNA 9 SCARNA9 -1,1603734 -1,428188 -1,790738 1,0699085 small Cajal body-specific RNA 9-like (retrotransposed) SCARNA9L -1,0196757 -1,1030102 -1,5123277 1,0706543 small nuclear ribonucleoprotein 48kDa (U11/U12) SNRNP48 -1,1847566 -1,6062301 -1,0426525 1,0427845 small nuclear ribonucleoprotein polypeptide A SNRPA -1,0682082 1,0164812 1,5808973 1,5465649 small nuclear ribonucleoprotein polypeptide A' SNRPA1 1,0323259 -1,6437902 -1,4374876 -1,0860177 small nuclear ribonucleoprotein polypeptide E SNRPE 1,077706 1,260379 1,2748281 1,6259764 SNRPG|LOC100 small nuclear ribonucleoprotein polypeptide G | small nuclear ribonucleoprotein G-like protein 130932 1,5061297 -1,0028446 1,129567 1,867913 small nuclear RNA activating complex, polypeptide 1, 43kDa SNAPC1 1,5452375 1,7118639 2,53882 2,585189 SNORD101|SNO small nucleolar RNA, C/D box 101 | small nucleolar RNA, H/ACA box 33 RA33 1,1870728 -1,0407771 1,0251627 1,5309687 small nucleolar RNA, C/D box 113-4 SNORD113-4 1,151125 -1,5516666 1,0873237 1,5851113 SNORD116- small nucleolar RNA, C/D box 116-21 | small nucleolar RNA, C/D box 116 cluster 21|SNORD116@ -1,0025681 -2,0300004 -1,0722156 1,563852 small nucleolar RNA, C/D box 116-6 SNORD116-6 1,2318528 -1,3741814 -1,4997927 1,7202163 small nucleolar RNA, C/D box 12C SNORD12C 1,5407761 1,1552272 -1,045466 1,2934531 small nucleolar RNA, C/D box 13 pseudogene 2 SNORD13P2 1,8291464 1,03034 -1,053877 1,2663015 small nucleolar RNA, C/D box 1A SNORD1A 1,7833537 1,2125596 -1,0320642 1,2422667 SNORD24|RPL7 small nucleolar RNA, C/D box 24 | ribosomal protein L7a A -1,5444931 2,0241697 1,5970308 1,362649 SNORD25|SNHG small nucleolar RNA, C/D box 25 | small nucleolar RNA host gene 1 (non-protein coding) 1 1,5175701 1,0349945 -1,1473713 1,1060501 SNORD36C|SNO small nucleolar RNA, C/D box 36C | small nucleolar RNA, C/D box 36A | ribosomal protein L7a RD36A|RPL7A 1,5031072 1,584863 1,264621 1,2818197 small nucleolar RNA, C/D box 38B SNORD38B 1,5422276 1,2018151 1,0377492 1,2267917 small nucleolar RNA, C/D box 42B SNORD42B 1,4758999 1,3392333 1,0427263 1,504754 small nucleolar RNA, C/D box 43 SNORD43 1,3275054 1,5195985 1,1032617 1,0960038 small nucleolar RNA, C/D box 44 SNORD44 1,6337148 1,4386013 1,062799 1,8496525 SNORD45B|RAB small nucleolar RNA, C/D box 45B | Rab geranylgeranyltransferase, beta subunit GGTB 1,2512805 -1,3372079 -1,5432582 1,1433128 small nucleolar RNA, C/D box 47 | growth arrest-specific 5 (non-protein coding) SNORD47|GAS5 1,314367 1,3988761 -1,0426514 1,8574052 small nucleolar RNA, C/D box 49A SNORD49A 1,399488 1,5975472 1,1927211 1,5410068 SNORD49B|NCR small nucleolar RNA, C/D box 49B | non-protein coding RNA 188 NA00188 1,0119249 1,1297044 1,216831 1,7292504 small nucleolar RNA, C/D box 4A SNORD4A 1,7005155 1,357335 1,1898158 1,3273944 small nucleolar RNA, C/D box 4B SNORD4B 1,814317 1,2867224 1,0192883 1,1681511 small nucleolar RNA, C/D box 5 | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa SNORD5|TAF1D 1,4016011 1,6350831 1,3271952 1,3171947 small nucleolar RNA, C/D box 50B SNORD50B 1,6272947 1,1472404 -1,169715 1,0433685 small nucleolar RNA, C/D box 56B SNORD56B 1,2020895 -1,3908906 -1,2064763 1,5904274 small nucleolar RNA, C/D box 59B SNORD59B 1,3863771 -2,09012 -1,4421737 -1,2869891 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 small nucleolar RNA, C/D box 75 SNORD75 1,7912648 1,7810669 -1,0227504 1,4693326 small nucleolar RNA, C/D box 76 | growth arrest-specific 5 (non-protein coding) SNORD76|GAS5 1,665937 1,7591778 1,143173 1,4003906 small nucleolar RNA, C/D box 78 SNORD78 1,9960153 2,0132067 1,4559263 1,4041337 small nucleolar RNA, C/D box 79 SNORD79 1,5669978 1,6893808 1,0874983 1,3502165 small nucleolar RNA, C/D box 80 | growth arrest-specific 5 (non-protein coding) SNORD80|GAS5 1,1562865 1,5245486 1,5380219 1,5080415 small nucleolar RNA, C/D box 82 SNORD82 1,4655612 -1,348335 1,0378082 1,6067075 small nucleolar RNA, H/ACA box 1 SNORA1 1,7032217 1,2691672 -1,0700457 1,0942702 small nucleolar RNA, H/ACA box 14B SNORA14B 1,5298179 -1,2024453 1,0482911 1,2243168 small nucleolar RNA, H/ACA box 24 SNORA24 1,0597157 -1,1125885 1,1300076 1,8317473 small nucleolar RNA, H/ACA box 27 SNORA27 1,5396602 -1,1350763 -1,0101932 1,131614 small nucleolar RNA, H/ACA box 29 SNORA29 1,7199843 -1,2175716 1,0122213 -1,0362198 small nucleolar RNA, H/ACA box 31 SNORA31 1,1613276 1,0452265 1,4171591 1,5423219 small nucleolar RNA, H/ACA box 36C (retrotransposed) SNORA36C 1,0010791 -1,599325 1,0600811 1,1313338 small nucleolar RNA, H/ACA box 40 | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, SNORA40|TAF1 41kDa D 1,3968464 1,5705636 1,3112819 1,7010771 small nucleolar RNA, H/ACA box 45 SNORA45 1,4579315 1,2005165 1,5142773 1,1377864 small nucleolar RNA, H/ACA box 46 SNORA46 1,207342 -1,5543296 1,1371777 1,2304611 small nucleolar RNA, H/ACA box 56 SNORA56 1,5054544 1,010611 1,1589959 1,1592444 small nucleolar RNA, H/ACA box 5A SNORA5A 1,5470793 -1,4291527 -1,0955315 1,1175145 small nucleolar RNA, H/ACA box 62 | ribosomal protein SA SNORA62|RPSA 1,2954006 1,5320675 1,1798915 -1,3008573 small nucleolar RNA, H/ACA box 68 SNORA68 1,3019632 -1,1281499 1,0626633 1,848454 SNORA73A|SNH small nucleolar RNA, H/ACA box 73A | small nucleolar RNA host gene 3 (non-protein coding) G3 1,0151683 -1,4948343 1,0251386 1,5467305 small nucleolar RNA, H/ACA box 75 SNORA75 1,9253781 -1,2284293 1,0891606 1,0902767 small nucleolar RNA, H/ACA box 80B SNORA80B -1,0334531 1,3792982 1,0676241 -1,603588 SNORA9|C7orf4 small nucleolar RNA, H/ACA box 9 | chromosome 7 open reading frame 40 0 2,554215 2,0462182 1,6654552 1,8340421 small proline-rich protein 1A SPRR1A -2,1810918 -1,5592425 -1,3588064 -1,2248648 small proline-rich protein 1B SPRR1B -1,6518503 -1,1267734 -1,0511128 -1,0698293 SPRR2A|SPRR2 small proline-rich protein 2A | small proline-rich protein 2B B -1,7042583 -1,2468903 -1,0590067 -1,0712329 smoothelin SMTN -1,01675 1,4726236 1,6841396 1,7550063 sodium channel, voltage-gated, type III, beta SCN3B 1,2848296 2,7700884 3,0243435 1,9298685 sodium channel, voltage-gated, type IX, alpha subunit SCN9A 1,106397 -1,5543445 1,0760622 -1,1696401 solute carrier family 1 (glial high affinity glutamate transporter), member 3 SLC1A3 2,4065754 1,5358381 1,0535486 -1,0414274 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 SLC1A4 -1,1680539 -1,240557 1,296915 1,7554524 solute carrier family 1 (neutral amino acid transporter), member 5 SLC1A5 1,0043504 1,3332951 1,2805468 1,5391626 solute carrier family 10 (sodium/bile acid cotransporter family), member 6 SLC10A6 2,7536054 3,5765052 2,9737546 3,1564236 solute carrier family 12 (sodium/potassium/chloride transporters), member 2 SLC12A2 -1,0714068 -2,2030745 -1,6302017 -1,4483626 solute carrier family 15 (H+/peptide transporter), member 2 SLC15A2 1,3168399 -1,0934485 -1,5011847 -1,9927148 solute carrier family 16, member 1 (monocarboxylic acid transporter 1) SLC16A1 1,1852642 3,2067254 3,2973647 2,5624874 solute carrier family 16, member 6 (monocarboxylic acid transporter 7) SLC16A6 1,0273985 -1,0736156 -1,0511104 1,5835341 solute carrier family 16, member 7 (monocarboxylic acid transporter 2) SLC16A7 1,1925662 2,6043077 2,7030702 3,1430461 solute carrier family 19 (thiamine transporter), member 2 SLC19A2 -1,1604283 -1,0328729 1,256941 1,6974663 solute carrier family 2 (facilitated glucose transporter), member 1 SLC2A1 -1,490021 -2,7687109 -1,5752653 -1,4643724 solute carrier family 2 (facilitated glucose transporter), member 12 SLC2A12 1,1219537 -2,7586894 -1,6170194 -1,3114635 solute carrier family 2 (facilitated glucose transporter), member 3 SLC2A3 -1,1446593 1,0231997 1,4697999 1,7681724 solute carrier family 2 (facilitated glucose transporter), member 9 SLC2A9 1,1204437 1,1179409 1,1207759 1,5294564 solute carrier family 20 (phosphate transporter), member 1 SLC20A1 1,4021358 1,4061084 1,7366862 2,1597376 solute carrier family 20 (phosphate transporter), member 2 SLC20A2 1,2147495 1,3178713 1,5995612 1,5545228 solute carrier family 22 (extraneuronal monoamine transporter), member 3 SLC22A3 1,6867702 1,9338406 1,9266124 2,1552231 solute carrier family 22 (organic cation/ergothioneine transporter), member 4 SLC22A4 1,0858971 1,3298789 1,3941809 2,3266928 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 solute carrier family 22, member 23 SLC22A23 -1,244369 1,4960889 2,2239506 2,2948077 solute carrier family 23 (nucleobase transporters), member 2 SLC23A2 1,3256581 -1,1140914 1,3499725 1,5945182 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 SLC25A15 1,2696106 1,5289121 1,3248215 1,0620759 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 SLC25A23 -1,1950536 -1,5028269 -1,5018557 -1,354226 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 SLC25A25 1,887807 1,3177786 1,9279622 1,6163685 solute carrier family 25, member 27 SLC25A27 1,4170227 -1,616663 -1,5198034 -1,3534613 solute carrier family 25, member 28 SLC25A28 1,2537487 1,064713 1,2547702 1,5820934 solute carrier family 25, member 37 SLC25A37 -1,0213629 1,5198677 1,0931038 1,0602216 solute carrier family 26, member 4 SLC26A4 -1,0530883 1,1381166 1,0983536 2,2466786 solute carrier family 26, member 9 SLC26A9 1,1840966 1,6170412 1,7862837 1,4465715 solute carrier family 27 (fatty acid transporter), member 2 SLC27A2 1,2260507 -1,5241073 -1,2970994 -1,5315396 solute carrier family 27 (fatty acid transporter), member 4 SLC27A4 1,0318333 -1,5593971 -1,0927013 -1,0496949 solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 SLC28A3 1,0949805 2,7633555 3,2525268 3,779752 solute carrier family 29 (nucleoside transporters), member 2 SLC29A2 -1,0588078 1,5194814 1,2080828 1,0819509 solute carrier family 30 (zinc transporter), member 1 SLC30A1 -1,1077682 1,1130115 1,3235496 1,55158 solute carrier family 30 (zinc transporter), member 7 SLC30A7 1,3106267 1,7114441 1,464386 1,4661149 SLC35A1|C6orf1 solute carrier family 35 (CMP-sialic acid transporter), member A1 | chromosome 6 open reading frame 165 65 1,0338306 -1,5391097 -1,3038343 -1,1460948 solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1 SLC35D1 -1,2424502 -2,2706683 -1,662164 -1,4477974 solute carrier family 37 (glycerol-3-phosphate transporter), member 2 SLC37A2 -1,068228 -2,4759448 -1,4736509 -1,2334507 solute carrier family 38, member 6 SLC38A6 1,1306472 -1,0057267 1,496306 1,703135 solute carrier family 39 (zinc transporter), member 1 SLC39A1 -1,0040604 1,1764203 1,5962868 1,5392134 solute carrier family 39 (zinc transporter), member 14 SLC39A14 1,2443156 1,140176 1,2707509 1,7730836 solute carrier family 39 (zinc transporter), member 2 SLC39A2 1,5558623 2,6109276 1,887215 2,0695162 solute carrier family 39 (zinc transporter), member 8 SLC39A8 1,1408893 1,5451721 1,6288364 2,8529568 solute carrier family 4, sodium borate transporter, member 11 SLC4A11 -1,1353672 -1,7270548 -1,425595 -1,6981329 solute carrier family 41, member 1 SLC41A1 1,50046 1,5312845 1,4147063 1,4499998 solute carrier family 43, member 2 SLC43A2 1,1746277 -1,0015898 1,2047048 1,5403188 solute carrier family 43, member 3 SLC43A3 1,5502764 2,8346994 2,0350327 2,284669 solute carrier family 44, member 2 SLC44A2 -1,2372848 -2,481615 -1,7117915 -1,8037994 solute carrier family 45, member 4 SLC45A4 1,5367842 1,1173934 1,7866038 1,2634186 solute carrier family 45, member 4 SLC45A4 1,1643528 -1,0577977 1,5845021 1,355931 solute carrier family 47, member 2 SLC47A2 1,1802635 -1,6065902 -1,1022277 -1,1991788 solute carrier family 6 (amino acid transporter), member 14 SLC6A14 1,8372406 1,883559 1,4877613 1,9573958 solute carrier family 6 (neurotransmitter transporter, creatine), member 8 | solute carrier family 6 SLC6A8|SLC6A1 (neurotransmitter transporter, creatine), member 10 (pseudogene) 0P -2,788631 -1,0282226 1,2295351 1,1037577 solute carrier family 6 (neurotransmitter transporter, creatine), member 8 | solute carrier family 6 SLC6A8|SLC6A1 (neurotransmitter transporter, creatine), member 10 (pseudogene) 0P -2,826771 -1,0329368 1,232335 1,1111406 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 SLC6A9 -1,0923489 -1,7809857 -1,0756626 1,0251204 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 SLC6A2 1,1798283 -2,1000319 -1,2549074 -1,4284769 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 SLC7A5 -1,1315205 -1,6209775 -1,326817 -1,0855106 solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 | solute carrier family 7, member SLC7A6|SLC7A6 6 opposite strand OS 1,2442309 -1,0754648 -1,5326729 -1,5005636 solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 SLC7A11 1,4626054 1,9860061 2,6394486 4,672055 solute carrier family 9 (sodium/hydrogen exchanger), member 8 SLC9A8 -1,0147188 -1,3108261 -1,635722 -1,389024 solute carrier organic anion transporter family, member 2A1 SLCO2A1 -1,2603015 2,2261732 4,08586 5,4821687 solute carrier organic anion transporter family, member 3A1 SLCO3A1 -1,0745716 -1,2598408 -1,7034924 -1,8682896 solute carrier organic anion transporter family, member 4A1 SLCO4A1 -1,5421497 -1,001462 1,7356339 1,7988454 solute carrier organic anion transporter family, member 4C1 SLCO4C1 1,6053163 -1,1200624 -1,1474763 -1,113162 sortilin 1 SORT1 -1,3825246 -1,4713285 -1,1697831 -1,6680583 sortilin-related receptor, L(DLR class) A repeats-containing SORL1 -1,1302258 -1,5177021 -1,6229172 -1,6047857 sorting nexin 10 SNX10 -1,1083373 1,226969 1,8476484 3,9240577 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 sorting nexin 24 SNX24 1,2387898 -1,9333556 -1,3267614 -1,2016518 sorting nexin family member 30 SPDYE1|SPDYESNX30 -1,0690397 -1,6884708 -1,3644373 -1,2726246 speedy homolog E1 (Xenopus laevis) | speedy homolog E5 (Xenopus laevis) | speedy homolog E2 (Xenopus 5|SPDYE2|SPDY laevis) | speedy homolog E7 (Xenopus laevis), pseudogene E7P -1,1499192 -1,3353671 -1,5639356 -1,2443308 speedy homolog E7 (Xenopus laevis), pseudogene SPDYE7P -1,1543887 -1,3215839 -1,6614012 1,2618387 spermatid perinuclear RNA binding protein STRBP 1,0784204 -1,5484877 -1,2028296 -1,155854 spermatogenesis associated 5 SPATA5 1,4140804 1,0080765 1,4472687 1,817137 spermidine synthase SRM 1,1956304 2,062724 1,4131613 1,2145005 spermidine/spermine N1-acetyltransferase 1 SAT1 1,0322467 -1,0219221 1,1552738 1,5360433 spermidine/spermine N1-acetyltransferase family member 2 SAT2 -1,0632349 -1,5320159 -1,2202446 -1,0839622 sphingomyelin phosphodiesterase, acid-like 3A SMPDL3A -1,0225482 -2,4670498 -1,5788159 -1,9094119 sphingomyelin synthase 1 SGMS1 1,2972592 1,5161098 1,540328 1,537658 sphingomyelin synthase 2 SGMS2 1,4185072 2,1172056 2,377123 2,6034505 sphingosine-1-phosphate phosphatase 2 SGPP2 1,078558 1,1268586 1,541984 2,7922592 sphingosine-1-phosphate receptor 1 S1PR1 1,047907 1,2676114 3,061394 5,0803413 spindle and centriole associated protein 1 SPICE1 1,0911729 -1,6429826 -1,2723453 -1,1431752 splA/ryanodine receptor domain and SOCS box containing 1 SPSB1 -1,4185377 -1,9558973 -1,5180317 -1,3729937 spondin 1, extracellular matrix protein SPON1 -1,020734 1,3003273 1,5456885 1,5214951 SPON2|LOC100 spondin 2, extracellular matrix protein | hypothetical LOC100322895 130872-SPON2 -1,1683991 -2,2542312 -1,4542061 -1,2144226 sprouty homolog 4 (Drosophila) SPRY4 -1,1016264 1,1298254 1,1931635 1,6671598 sprouty-related, EVH1 domain containing 1 SPRED1 1,3031756 2,2115088 2,1421182 2,3464818 sprouty-related, EVH1 domain containing 2 SPRED2 1,3801588 1,2660956 1,2578429 1,5435152

SPRY domain containing 4 SPRYD4 1,24094 1,520136 1,1226463 -1,022362

SPRY domain containing 5 SPRYD5 -1,2658442 1,2464705 1,2469893 -1,7611372 squalene epoxidase SQLE 1,0428451 1,1848624 3,007079 3,7254143

Src homology 2 domain containing adaptor protein B | cytoskeleton associated protein 2 SHB|CKAP2 1,1960138 1,8275824 1,4669428 1,5135432

SRY (sex determining region Y)-box 2 SOX2 1,3923289 1,2417516 1,7823997 1,2789044

SRY (sex determining region Y)-box 9 SOX9 1,1118673 1,6813043 2,0562773 1,3156344

ST3 beta-galactoside alpha-2,3-sialyltransferase 1 ST3GAL1 1,112286 1,1380918 1,485099 1,5875089 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 ST6GALNAC1 1,1387563 2,0149088 1,253946 1,4536495 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 ST6GALNAC2 -1,1220194 -2,0347612 -1,905818 -1,5836911

STAM binding protein-like 1 STAMBPL1 1,9199747 1,1967869 1,2435402 1,4372933 stanniocalcin 1 STC1 -1,3442253 1,6830218 2,817883 3,4327655

StAR-related lipid transfer (START) domain containing 10 STARD10 -1,3278708 -1,679613 -1,1587442 -1,027341

StAR-related lipid transfer (START) domain containing 13 STARD13 1,0134662 -1,3421215 -1,8379306 -1,4921688

StAR-related lipid transfer (START) domain containing 4 STARD4 -1,2469584 -1,5553513 2,058347 2,3996065

StAR-related lipid transfer (START) domain containing 5 | interleukin 16 (lymphocyte chemoattractant factor) STARD5|IL16 2,1636443 2,1150143 1,6133716 1,6008115

STARD3 N-terminal like STARD3NL 1,4980819 1,3236599 1,4304377 1,3695283 statherin STATH 1,4780753 -2,043678 -1,1535457 -1,17562 stathmin-like 3 STMN3 -1,1522285 1,089741 1,5136133 1,2771679

STE20-related kinase adaptor beta STRADB -1,0425949 -1,6309777 1,0561938 1,0298115

STE20-related kinase adaptor beta STRADB -1,029879 -1,6356895 1,0469618 1,0140067

STEAP family member 3 STEAP3 1,0236928 -1,7871524 -1,4337491 -1,3668928

STEAP family member 4 STEAP4 3,3022661 10,799909 12,775411 16,905989 stearoyl-CoA desaturase (delta-9-desaturase) SCD -1,2500511 -2,5084076 1,0933849 1,3211397 stearoyl-CoA desaturase (delta-9-desaturase) SCD -1,3442298 -3,0921967 -1,1889418 1,2979587 sterile alpha motif and leucine zipper containing kinase AZK ZAK 1,141726 1,3666149 1,8019141 3,2137697 sterile alpha motif domain containing 12 SAMD12 1,7306427 -1,4177451 -1,5669625 -1,872187 sterile alpha motif domain containing 3 SAMD3 -1,0004998 1,394675 3,425274 2,733922 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 sterile alpha motif domain containing 9-like SAMD9L 1,619103 -1,1805195 -1,8930018 -1,0759214 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) SRD5A2 -1,0328068 1,5088292 1,2300164 -1,0660472 sterol O-acyltransferase 1 SOAT1 1,1741697 -1,0220627 1,3269889 1,5819904 sterol regulatory element binding transcription factor 1 SREBF1 1,0090187 -2,8437045 -1,7738608 -1,4998536 sterol-C4-methyl oxidase-like SC4MOL 1,0781449 1,4661304 4,014747 4,6698318 sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like SC5DL -1,0729986 -1,5418448 1,2743318 1,2781823 stomatin STOM 2,0149927 7,8084664 9,45395 8,497885 stratifin SFN 1,178 1,6086539 1,5721049 1,675315 strawberry notch homolog 2 (Drosophila) SBNO2 1,5262357 2,094168 2,3246605 2,5361087 stromal antigen 3-like 4 STAG3L4 -1,2766159 -1,853334 -1,2570091 -1,2416493 succinatestructural maintenancedehydrogenase of chromosomescomplex, subunit 4 A, flavoprotein pseudogene 1 | succinate dehydrogenase SMC4 -1,0269272 -1,5282073 1,1389121 1,1157585 complex, subunit A, flavoprotein pseudogene 2 | succinate dehydrogenase complex, subunit A, flavoprotein SDHAP1|SDHAP succinate(Fp) dehydrogenase complex, subunit A, flavoprotein pseudogene 2 | succinate dehydrogenase 2 -1,0474935 -1,4189584 -1,3834662 -1,5177032 complex, subunit A, flavoprotein (Fp) | succinate dehydrogenase complex, subunit A, flavoprotein pseudogene SDHAP2|SDHAP 1succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 2 | succinate dehydrogenase 1 1,1096829 -1,3803558 -1,4898043 -1,5430082 complex, subunit A, flavoprotein pseudogene 1 | succinate dehydrogenase complex, subunit A, flavoprotein SDHAP2|SDHAP (Fp) 1|LOC220729 -1,0319622 -1,5074385 -1,4781388 -1,5210155 sulfatase 2 SULF2 1,2255347 1,0501579 1,9868032 1,4706808 sulfide quinone reductase-like (yeast) SQRDL -1,0603912 1,3083553 1,5178767 1,9466542 sulfotransferase family 1E, estrogen-preferring, member 1 SULT1E1 1,051649 -1,8282489 -1,5811194 -2,2640405 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 32 | SLX1 structure-specific endonuclease SULT1A2 1,1046709 -1,1646645 1,5422037 -1,0338138 subunit homolog A (S. cerevisiae) | SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) | SULT1A3|SLX1A sulfotransferase family, cytosolic, 1A, phenol-preferring, member 34 | SLX1 structure-specific endonuclease |SLX1B|SULT1A4 1,0920695 -1,0011991 1,4458106 1,6123075 subunit homolog A (S. cerevisiae) | SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) | SULT1A3|SLX1A sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 |SLX1B|SULT1A4 1,1020591 -1,0014613 1,4352653 1,5145432 superoxide dismutase 2, mitochondrial SOD2 1,5450721 2,904364 3,2345102 4,948756 suppression of tumorigenicity 5 ST5 1,7302784 5,9730916 3,9668195 4,1278186 suppressor of cytokine signaling 1 SOCS1 1,2750713 1,5296359 1,4109935 1,1813033 suppressor of cytokine signaling 2 SOCS2 1,9342638 2,969332 4,4401636 2,260356 suppressor of cytokine signaling 3 SOCS3 5,380352 4,783007 5,9412146 6,2319627 surfactant protein D SFTPD -1,2023637 1,571387 1,0812509 -1,0890886 sushi domain containing 4 SUSD4 -1,0556445 -1,521036 -2,0801854 -1,6796986 synapse defective 1, Rho GTPase, homolog 2 (C. elegans) SYDE2 -1,199287 -2,1327155 -1,8198693 -1,5936077 synaptotagmin VII SYT7 -1,3864967 -2,811803 -1,5817305 -1,5512072 synaptotagmin XIV SYT14 -1,992176 -2,110101 -1,0185912 1,19531 synaptotagmin-like 2 SYTL2 -1,1167617 -1,6075542 -2,004577 -1,8751534 synaptotagmin-like 4 SYTL4 -1,1367669 -1,7920169 -1,3910565 -1,5793505 synaptotagmin-like 5 SYTL5 1,09566 2,5459669 1,4418316 -1,2309452 syndecan 1 SDC1 -1,3742794 -1,7487788 -1,2965884 -1,1938463 syndecan binding protein (syntenin) SDCBP 1,0437155 1,5905325 1,6983945 1,854603 syndecan binding protein (syntenin) 2 SDCBP2 -1,1049273 -1,6282599 -1,2999233 -1,1205703 syntaxin 11 STX11 3,7536788 3,5755136 3,317719 3,9061139 syntaxin 19 STX19 -1,0057806 -1,4795685 -1,7538495 -1,6947143 syntaxin 1B STX1B -1,1425629 1,5942768 -1,0403152 -1,1046296 syntaxin 3 STX3 1,0492219 -1,7990648 -1,064865 -1,0990502 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) SNTB2 1,1697924 1,1720232 1,5365236 1,4093095 synuclein, alpha (non A4 component of amyloid precursor) SNCA -1,0599158 -1,0888287 -1,3561431 -1,6606479 synuclein, alpha interacting protein SNCAIP -1,1003063 1,7960134 2,8361173 2,1554952 synuclein, gamma (breast cancer-specific protein 1) SNCG -1,0990988 -1,0295192 -1,5450531 -1,4358333

T cell receptor beta variable 23/OR9-2 (non-functional) TRBV23OR9-2 -1,07575 1,5078038 1,0033989 -1,2552605

T-cell lymphoma invasion and metastasis 1 TIAM1 1,4986782 3,0642517 2,066327 1,9446748 t-complex 11 (mouse)-like 2 TCP11L2 -1,2795433 -2,3636875 -1,4142958 -1,394297 tandem C2 domains, nuclear TC2N 1,01387 2,9400234 8,108615 12,849994 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 taperin TPRN -1,2411484 -1,6594074 -1,3241937 -1,2000091 target of myb1-like 2 (chicken) TOM1L2 -1,0311868 -1,7063754 -1,5706643 -1,8192276 taste receptor, type 2, member 19 TAS2R19 1,3255827 -1,6647971 -1,2579734 1,1973803 taste receptor, type 2, member 4 TAS2R4 1,2562706 -1,658131 -1,2072458 -1,2148751 taste receptor, type 2, member 50 TAS2R50 1,2429222 -1,6354636 -1,2308753 1,1299878 taste receptor, type 2, member 60 TAS2R60 -1,0004456 1,6533136 1,5768504 1,6657895

TBC1 domain family, member 2 TBC1D2 1,4228404 1,6317078 1,5575633 2,267391

TBC1 domain family, member 2B TBC1D2B -1,0089573 -1,7598861 -1,2463844 -1,1230783

TBC1 domain family, member 8 (with GRAM domain) TBC1D8 -1,1117247 -1,7096717 -1,2628266 -1,4460763 TCTEX1D2|TM4 Tctex1 domain containing 2 | transmembrane 4 L six family member 19 SF19 1,0820739 1,0328709 1,2836131 1,5166987

TEA domain family member 4 TEAD4 1,4503703 1,7704636 1,4794267 1,1799176 teashirt zinc finger homeobox 2 TSHZ2 1,0572363 -1,0772319 1,3644058 2,0354714 teashirt zinc finger homeobox 2 TSHZ2 1,0938153 -1,038344 1,2920576 1,5798631 tectonic family member 2 TCTN2 -1,0839804 -1,701045 -1,2800645 -1,257074 tektin 2 (testicular) TEKT2 1,1331272 1,5147544 1,0472802 1,1741478 tensin 3 TNS3 1,1955458 -1,7567933 -1,6971903 -1,2887365

TERF1 (TRF1)-interacting nuclear factor 2 TINF2 1,5204364 1,4728523 1,720562 2,3140388 testis expressed 12 TEX12 1,2551455 -1,5761647 -1,2310616 1,1470827 testis-specific kinase 2 TESK2 -1,1278621 -1,836659 -1,3105999 -1,3599161 tetra-peptide repeat homeobox-like TPRXL -1,2165792 -1,6506616 -1,2686094 -1,1799468 tetraspanin 14 TSPAN14 -1,1143551 -1,7578132 -1,1933209 -1,3746283 tetraspanin 15 TSPAN15 1,0247498 1,8745071 1,5541159 1,4242717 tetraspanin 16 TSPAN16 -1,4841769 1,1257411 -1,1104145 -1,6140313 tetraspanin 5 TSPAN5 -1,1017772 -1,6151296 -1,2963562 -1,2152284 tetratricopeptide repeat domain 22 TTC22 -1,2142934 -1,6396663 -1,2738863 -1,412135 tetratricopeptide repeat domain 30B TTC30B -1,3094863 -1,6441146 1,0382397 -1,1253263 tetratricopeptide repeat domain 39A TTC39A -1,0408947 1,0908048 1,3252239 1,9933425 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 TANC1 -1,0504751 -1,541483 -1,237063 -1,3163921 thioesterase superfamily member 5 THEM5 1,0883272 -1,6433014 -1,5784972 -1,434986 TXNDC17|MED3 thioredoxin domain containing 17 | mediator complex subunit 31 | KIAA0753 1|KIAA0753 1,2110565 2,070532 2,1594942 2,111025 thioredoxin interacting protein TXNIP -1,9236963 -1,8481193 -1,6174614 -1,393512 TXNRD3|TXNRD thioredoxin reductase 3 | thioredoxin reductase 3 intronic transcript 1 3IT1 1,0503283 1,2052974 1,5619318 1,173581 thioredoxin-like 4A TXNL4A 1,241669 1,1055951 1,2295643 1,6460308 thioredoxin-like 4B TXNL4B 1,137242 1,0966698 1,5048071 1,5840659 thiosulfate sulfurtransferase (rhodanese) TST 1,1165066 -1,0838952 1,1783131 1,7363775 threonyl-tRNA synthetase TARS 1,1552211 1,3749846 1,4458401 1,7536014 threonyl-tRNA synthetase-like 2 TARSL2 1,3514725 1,5723295 1,4974265 1,3926547 thrombomodulin THBD 1,4691398 1,9127457 1,8995205 1,8144189 thymidine phosphorylase | SCO cytochrome oxidase deficient homolog 2 (yeast) | outer dense fiber of sperm TYMP|SCO2|OD tails 3B F3B 1,056698 1,2561154 1,2062682 1,6176839 thymosin beta 10 TMSB10 -1,1037607 1,1319371 1,4775859 1,8368326 thymosin beta 4, X-linked | thymosin-like 3 TMSB4X|TMSL3 -1,0743941 1,0338973 1,2582163 1,8050375 thymosin beta 4, X-linked | thymosin-like 3 | breast carcinoma amplified sequence 4 | thymosin-like 6 TMSB4X|TMSL3| (pseudogene) BCAS4|TMSL6 -1,0914605 1,0318633 1,2323292 1,7384528 TMSB4X|TMSL3| thymosin beta 4, X-linked | thymosin-like 3 | thymosin-like 6 (pseudogene) TMSL6TMSL3|TMSB4X| -1,1025583 1,0020301 1,1858622 1,9418577 thymosin-like 3 | thymosin beta 4, X-linked | thymosin beta 4, X-linked pseudogene 2 | thymosin-like 6 TMSB4XP2|TMS (pseudogene) L6 -1,0597382 1,0162077 1,2433043 1,7830188 tight junction protein 3 (zona occludens 3) TJP3 -1,1215196 -1,8644404 -1,5242676 -2,421611

TIMP metallopeptidase inhibitor 3 TIMP3 -1,3861109 -1,8960192 -1,5110676 -1,0407959 tissue factor pathway inhibitor 2 TFPI2 1,33611 1,1590518 1,3001227 1,6330351 tissue specific transplantation antigen P35B TSTA3 1,6386961 2,0456367 1,5119474 1,7355696 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31

TLC domain containing 1 TLCD1 1,446122 1,6339529 1,3004146 1,2779495

TM2 domain containing 3 TM2D3 1,6272775 1,2287673 1,1035141 1,0973923

TNFAIP3 interacting protein 3 TNIP3 1,3086058 3,3338943 5,163074 5,9142437 toll-like receptor 2 TLR2 1,0443245 1,6990149 1,7467709 2,2222939 toll-like receptor 3 TLR3 -1,0094976 -1,2826945 -1,6500278 -1,6419961 toll-like receptor 5 TLR5 1,0064067 -1,0817032 -1,8024842 -1,0827415 toll-like receptor 6 TLR6 -1,137698 -1,5573152 -1,136735 -1,2975316 toll-like receptor adaptor molecule 1 TICAM1 1,4450465 1,6073332 1,1729667 1,2964376 topoisomerase (DNA) I TOP1 1,26228 1,5085142 1,3501153 1,2602273 topoisomerase (DNA) II alpha 170kDa TOP2A -1,0025847 -1,7995715 -1,1266207 1,5139726 topoisomerase (DNA) II beta 180kDa TOP2B 1,060155 -1,5468144 -1,1681303 -1,0426983

TP53 target 1 (non-protein coding) TP53TG1 1,0073729 -1,6941297 -1,7146935 -1,5088367

TRAF-type zinc finger domain containing 1 TRAFD1 -1,2401572 -1,8220546 -1,5536455 -1,5942779 trafficking protein particle complex 4 TRAPPC4 1,2537371 1,2600341 1,2636408 1,6517695 trafficking protein particle complex 6A TRAPPC6A -1,0210612 1,0660405 -1,2766674 -1,6727848 trafficking protein, kinesin binding 1 TRAK1 1,051083 -1,5761225 -1,1260645 -1,0339328 trafficking protein, kinesin binding 2 TRAK2 -1,0767119 -1,7374281 -1,3924521 -1,2988179 transcobalamin I (vitamin B12 binding protein, R binder family) TCN1 1,4373327 2,2825723 1,3170301 2,548197 transcription elongation factor A (SII), 3 TCEA3 -1,2560265 -1,6002698 -1,1102456 -1,1267756 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) TFAP2A -1,3769602 -1,6092452 -1,4001093 -1,0806208 transcriptional regulating factor 1 TRERF1 -1,0208459 -1,5919425 -1,1338282 -1,207884 transducer of ERBB2, 1 TOB1 -1,4911886 -2,0746882 -1,5044073 -1,6128064 transducin (beta)-like 1X-linked TBL1X -1,0781167 -1,5055708 1,0641034 1,2424428 transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila) TLE3 1,1134832 1,6155119 2,15475 2,0484593 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) TLE4 -1,0824853 -1,8761212 -1,4631784 -1,7675636 transferrin receptor (p90, CD71) TFRC 1,4084005 1,7541834 1,7002739 1,2121665 transforming growth factor, alpha TGFA 1,3305433 1,5319521 1,4930543 2,0712824 transforming growth factor, beta 1 TGFB1 -1,6275814 -1,2700962 1,382017 1,5312455 transforming growth factor, beta receptor 1 TGFBR1 1,1397066 -1,0561401 1,3957642 1,6919646 transforming growth factor, beta-induced, 68kDa TGFBI -1,0928321 -1,4561906 -1,5737759 -1,3879381 transforming, acidic coiled-coil containing protein 1 TACC1 1,5647439 1,4851152 1,3688676 1,121759 transforming, acidic coiled-coil containing protein 2 TACC2 -1,0476116 -1,9671717 -1,6235175 -1,6036447 transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) TGM1 -1,2797709 1,4549128 2,0737834 2,483274 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) TGM2 -1,0492117 2,971166 8,782877 9,402476 transglutaminase 5 TGM5 1,0925479 -1,2356203 -1,4494565 -1,5763825 transient receptor potential cation channel, subfamily C, member 2-like LOC100133315 1,1392969 -1,4730023 -1,3111163 -1,7135644 transient receptor potential cation channel, subfamily M, member 6 TRPM6 1,3800739 3,4955814 2,6947937 2,2510953 transient receptor potential cation channel, subfamily V, member 1 | sedoheptulokinase TRPV1|SHPK 1,1968427 -1,5258754 -1,2143914 -1,1336715 transient receptor potential cation channel, subfamily V, member 4 TRPV4 -1,8997303 -1,4288538 -1,106007 -1,0983351 transient receptor potential cation channel, subfamily V, member 6 TRPV6 1,1772375 -1,0005273 -1,5588236 -1,65384 transketolase TKT -1,0826671 -1,618302 -1,1929438 1,3143523 translocase of inner mitochondrial membrane 8 homolog A (yeast) TIMM8A 1,9714774 1,569839 1,1712513 -1,081258 transmembrane 4 L six family member 1 TM4SF1 1,7862289 2,8697035 3,218582 4,002238 transmembrane 4 L six family member 19 TM4SF19 -1,0604568 1,0931402 2,027346 5,9490156 transmembrane and coiled-coil domain family 3 TMCC3 -1,5342562 -1,5672526 -1,3194805 -1,447883 transmembrane and tetratricopeptide repeat containing 3 TMTC3 1,1743063 -1,547648 -1,252858 -1,1564107 transmembrane channel-like 1 TMC1 -1,0966846 1,8962173 3,5745919 3,0774758 transmembrane channel-like 5 TMC5 1,4046038 2,5402043 2,6828105 2,7463768 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 transmembrane channel-like 7 TMC7 -1,0380499 -1,5619887 1,1835308 1,6209208 transmembrane protease, serine 11A TMPRSS11A 1,1069267 1,677923 1,437979 1,4901913 transmembrane protease, serine 11D TMPRSS11D 1,2161868 1,4320475 1,5509524 1,6312759 transmembrane protease, serine 11E TMPRSS11E 1,9441086 1,136743 -1,154681 -1,1282532 transmembrane protease, serine 11E TMPRSS11E 1,9437225 1,1512444 -1,1129578 -1,1386483 transmembrane protease, serine 11F TMPRSS11F -1,0954659 -1,0077977 1,1047629 1,8764945 transmembrane protease, serine 13 TMPRSS13 -1,0393432 -1,4011962 1,3020562 1,5474541 transmembrane protease, serine 4 TMPRSS4 1,0235995 1,4425646 1,6234279 2,0131848 transmembrane protein 116 TMEM116 -1,0099381 -1,6178287 -1,19624 -1,2914287 transmembrane protein 117 TMEM117 1,612921 -1,4956192 -1,2245588 -1,1404829 transmembrane protein 132E TMEM132E -1,2504268 1,0207258 -1,0219377 -1,5542967 transmembrane protein 133 TMEM133 1,0645852 -2,4833617 -1,9794371 -2,3571901 transmembrane protein 135 TMEM135 1,0755819 -1,7653799 1,1211194 1,130392 transmembrane protein 14A TMEM14A -1,0115712 -1,6718866 -1,5468931 -1,5594053 transmembrane protein 154 TMEM154 -1,0467722 1,092328 1,510349 1,9277532 transmembrane protein 168 TMEM168 1,1421099 -1,5603117 -1,0287787 -1,0255721 transmembrane protein 171 TMEM171 1,1223295 2,9103978 3,6498518 4,178382 transmembrane protein 173 TMEM173 1,5469157 3,0911002 2,490634 2,8722599 transmembrane protein 19 TMEM191A|TMETMEM19 1,0628383 -1,5246253 -1,2517381 -1,5883209 M191B|TMEM19 transmembrane protein 191A | transmembrane protein 191B | transmembrane protein 191C 1C -1,1771337 -1,0169193 -1,1884032 -1,5186605 transmembrane protein 194A TMEM194A -1,0387378 -1,5627798 1,2441971 1,1850002 transmembrane protein 2 TMEM2 2,127327 2,670139 1,900793 2,2438252 transmembrane protein 200A TMEM200A 1,0006592 1,6373729 2,5370376 3,2328537 transmembrane protein 30B TMEM30B 1,3413521 2,274266 2,429738 2,8534546 transmembrane protein 33 TMEM33 1,2685713 1,613346 1,4106237 1,2873834 transmembrane protein 37 TMEM37 -1,0864532 -2,4158168 -2,1140275 -2,6909833 transmembrane protein 40 TMEM40 -1,1828793 -1,7785791 -2,2864132 -2,0111508 transmembrane protein 45A TMEM45A -2,443831 -1,295353 1,0639296 1,1756138 transmembrane protein 63B TMEM63B 1,014649 -1,648314 -1,1700221 -1,2432122 transmembrane protein 65 TMEM65 -1,1897268 -1,5597641 -1,0501628 1,0935016 transmembrane protein 8A TMEM8A -1,1568346 1,0338433 1,4693817 1,528771 transmembrane protein 97 TMEM97 1,0438914 1,006394 1,5776986 1,4336505 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) TAP2 1,913022 1,6155583 -1,2012178 -1,0015388 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) TAP2 1,8347732 1,5594388 -1,1532358 -1,0131397 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) TAP2 1,7539463 1,5416487 -1,17979 -1,0157194 tribbles homolog 1 (Drosophila) TRIB1 1,0422863 2,138297 2,301458 2,6926641 tribbles homolog 3 (Drosophila) TRIB3 1,0411483 1,0181603 1,5126082 2,0014832 trinucleotide repeat containing 6B TNRC6B 1,132399 -1,5585757 -1,1468613 -1,1724067 triosephosphate isomerase 1 TPI1 -1,5529739 -1,2086308 -1,1415434 -1,0776739 tripartite motif-containing 14 TRIM14 1,3425106 2,0565553 1,0718162 1,1341745 tripartite motif-containing 2 TRIM2 -1,074767 -1,7487297 -1,64909 -1,4350799 tripartite motif-containing 22 TRIM22 1,5472368 1,3214698 -2,2509546 1,0227797 tripartite motif-containing 24 TRIM24 -1,1426914 -1,7638636 -1,0838891 -1,1044523 tripartite motif-containing 31 TRIM31 -1,2615192 -3,0374043 -3,8259416 -4,5889544 tripartite motif-containing 31 TRIM31 -1,2334466 -3,1692023 -4,0545673 -4,69116 tripartite motif-containing 31 TRIM31 -1,2550265 -3,2273383 -4,122177 -5,027083 tripartite motif-containing 38 TRIM38 -1,1325023 -1,9126939 -1,3817152 -1,0147691 tripartite motif-containing 45 TRIM45 1,1118078 -1,1814644 -1,6080703 -1,0763677 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 tripartite motif-containing 52 TRIM52 -1,1340665 -1,5082204 -1,3661313 -1,2976637 tripartite motif-containing 52 TRIM52 1,1964622 -1,0328364 1,4140663 1,5421853 tripartite motif-containing 59 TRIM59 1,0142913 -1,5036204 -1,151246 -1,0301452 tripartite motif-containing 62 TRIM62 -1,2526978 -1,1415917 -1,1422895 -1,6319402

TRK-fused gene TFG 1,0341448 1,528948 1,5227509 1,4937191

TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae) TRMT2B 1,0282993 -1,5973607 -1,2582582 -1,395606 tRNA methyltransferase 6 homolog (S. cerevisiae) TRMT6 1,3458577 1,556101 1,2640911 1,3563637 tRNA nucleotidyl transferase, CCA-adding, 1 TRNT1 1,6248251 1,0803894 1,3006505 1,3876176 trophinin associated protein (tastin) TROAP -1,0831052 -1,8725485 1,0472318 1,1253144 tropomodulin 2 (neuronal) TMOD2 1,1032982 -1,6362319 -1,9456604 -1,6673995 troponin T type 1 (skeletal, slow) TNNT1 -1,7171628 -1,1338603 -1,0335782 -1,151555 tryptophan 2,3-dioxygenase TDO2 1,8009804 2,0672643 1,0688616 1,5735096 tryptophanyl-tRNA synthetase WARS 2,0695407 3,7865355 4,573206 6,4414206

Ts translation elongation factor, mitochondrial TSFM 1,2789971 1,5021034 1,295523 1,4890432

TSC22 domain family, member 3 TSC22D3 -1,3771777 -2,3831687 -1,8535 -2,2660499

TSPY-like 1 TSPYL1 1,0170729 -1,8621334 -1,1884688 -1,1775951 tubulin polymerization-promoting protein family member 3 TPPP3 -1,0013124 -2,082611 -1,0011013 -1,7040483 tubulin, alpha 1c TUBA1C 1,0877079 -1,1562922 1,2735167 1,6468241 tubulin, alpha pseudogene MGC16703 -1,1221974 -1,5134412 -1,5265691 -1,2414893 tubulin, beta 6 TUBB6 -1,0368471 1,4575773 1,4285988 1,6861888 tubulin, gamma 2 TUBG2 1,0732462 -1,2673784 -1,4757751 -1,6828237 tudor and KH domain containing TDRKH 1,303631 1,7238196 3,4770918 3,8183088 tudor domain containing 9 TDRD9 1,0052484 1,0744363 1,083734 2,2308047 tumor necrosis factor (ligand) superfamily, member 15 TNFSF15 -1,5575113 -1,2982432 -1,6334907 -1,4586492 tumor necrosis factor (ligand) superfamily, member 18 TNFSF18 1,1118001 1,1469368 1,6607615 2,0875828 tumor necrosis factor receptor superfamily, member 10a TNFRSF10A 1,7927852 1,5186329 1,8214134 1,8281461 tumor necrosis factor receptor superfamily, member 10b TNFRSF10B 1,0730625 1,5102872 1,4400998 1,6376662 tumor necrosis factor, alpha-induced protein 1 (endothelial) TNFAIP1 1,3168334 1,8477784 1,6568655 1,7779368 tumor necrosis factor, alpha-induced protein 2 TNFAIP2 1,1475582 1,18607 -1,812266 -1,9973087 tumor necrosis factor, alpha-induced protein 3 TNFAIP3 1,0746129 1,813275 1,4851681 1,8537297 tumor necrosis factor, alpha-induced protein 6 TNFAIP6 1,0612061 1,4416333 -1,358659 2,01287 tumor protein D52 TPD52 -1,3925428 -1,3926598 -1,7233456 -1,6397412 tumor protein p53 inducible nuclear protein 1 TP53INP1 -1,1482959 -2,4385912 -1,1967248 -1,2519904 tweety homolog 2 (Drosophila) TTYH2 -1,2439809 -1,6869898 1,1453567 1,3223201 tyrosyl-tRNA synthetase YARS 1,115597 1,4807363 1,64112 2,3594007 ubiquitin associated and SH3 domain containing B UBASH3B 1,4805601 2,4842625 2,618891 2,8273046 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) UCHL3 1,1611491 1,6398187 1,4901885 1,6185983 USP17L2|USP17 ubiquitin specific peptidase 17-like 2 | ubiquitin specific peptidase 17 | ubiquitin specific peptidase 17-like 1 L1P|USP17L3|U (pseudogene) | ubiquitin specific peptidase 17-like 3 | ubiquitin specific peptidase 17-like 8 SP17L8 -1,0154697 1,1641431 1,2474778 1,5665467 USP17L2|USP17 ubiquitin specific peptidase 17-like 2 | ubiquitin specific peptidase 17 | ubiquitin specific peptidase 17-like 8 | L8|USP17L1P|U ubiquitin specific peptidase 17-like 1 (pseudogene) | ubiquitin specific peptidase 17-like 3 SP17L3 1,0670063 1,0085315 1,2201717 1,7953879 USP17L2|USP17 ubiquitin specific peptidase 17-like 2 | ubiquitin specific peptidase 17 | ubiquitin specific peptidase 17-like 8 | L8|USP17L1P|U ubiquitin specific peptidase 17-like 1 (pseudogene) | ubiquitin specific peptidase 17-like 3 SP17L3 1,0695596 -1,0000043 1,2272854 1,7696323 USP17L2|USP17 ubiquitin specific peptidase 17-like 2 | ubiquitin specific peptidase 17-like 1 (pseudogene) | ubiquitin specific L1P|USP17L3|U peptidase 17-like 3 | ubiquitin specific peptidase 17-like 8 | ubiquitin specific peptidase 17 SP17L8 -1,0247467 1,1904919 1,2752001 1,5898829 USP17L2|USP17 ubiquitin specific peptidase 17-like 2 | ubiquitin specific peptidase 17-like 3 | ubiquitin specific peptidase 17- L3|USP17L1P|U like 1 (pseudogene) | ubiquitin specific peptidase 17-like 8 | ubiquitin specific peptidase 17 SP17L8 -1,0374961 1,1833513 1,2862049 1,6122324 ubiquitin specific peptidase 17-like 6 (pseudogene) | ubiquitin specific peptidase 17 USP17L6P 1,003572 1,0362202 1,0220208 1,5444016 ubiquitin specific peptidase 18 USP18 -1,2037785 -1,0484259 1,2789662 1,5793843 ubiquitin specific peptidase 18 | ubiquitin specific peptidase 41 USP18|USP41 1,2646135 -1,1586018 1,4627944 2,571339 ubiquitin specific peptidase 43 USP43 1,8532366 1,7463541 1,6829444 1,3759384 ubiquitin-conjugating enzyme E2C UBE2C 1,0478965 -1,6463202 -1,0435023 -1,1948944 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) UBE2D1 1,0050904 1,1244154 1,39921 1,5273792 ubiquitin-conjugating enzyme E2L 6 UBE2L6 1,2153952 1,911243 -1,0608428 1,0426204 ubiquitin-conjugating enzyme E2N-like UBE2NL 1,074539 1,5235 1,2947226 1,1713233 ubiquitin-conjugating enzyme E2Q family member 2 UBE2Q2 -1,0609024 1,1959925 1,6308042 1,5546564

UBE2Q2P3|LOC 388152|LOC8015 ubiquitin-conjugating enzyme E2Q family member 2 pseudogene 3 | hypothetical LOC388152 | hypothetical 4|LOC727849|LO LOC80154 | golgin A2 pseudogene | hypothetical LOC727751 | ubiquitin-conjugating enzyme E2Q family C727751|UBE2Q member 2 pseudogene 2 | ubiquitin-conjugating enzyme E2Q family member 2 pseudogene 1 | hypothetical 2P2|UBE2Q2P1| LOC642423 LOC642423 -1,3007064 -1,7585117 -1,6227745 -1,8086362 ubiquitin-like 3 UBL3 -1,0065714 -1,6974814 -1,1667578 -1,2213167 ubiquitin-like modifier activating enzyme 6 UBA6 1,4248037 2,0283298 2,5811746 2,633249 ubiquitin-like modifier activating enzyme 7 UBA7 1,1206589 -1,17197 -1,5956353 -1,3124032 ubiquitination factor E4B (UFD2 homolog, yeast) UBE4B -1,0447191 -1,5512215 -1,0113438 -1,039371

UBX domain protein 8 UBXN8 1,1989101 1,2898406 1,4166013 1,5883188

UDP glucuronosyltransferase 2 family, polypeptide B7 UGT2B7 1,0025177 1,0761796 -1,5520164 -1,2240226

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 B4GALT4 -1,264107 -1,509804 -1,9662441 -1,5008444

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 B4GALT5 1,2822096 -1,1039445 -1,4799818 -1,5168606

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 B3GNT3 1,5517051 1,4904022 1,4511931 1,2153727

UDP-glucose 6-dehydrogenase UGDH 1,2820375 1,5186685 1,8616288 1,6491249

UDP-glucose ceramide glucosyltransferase UGCG 2,576892 4,0875506 3,7622416 4,309154

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) GALNT1 1,3586824 1,9232246 2,3431895 2,371762

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10) GALNT10 1,0792401 1,0738977 1,5639186 1,7666594

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2) GALNT2 -1,0081992 1,6098878 2,164278 1,6410364 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4) | POC1 centriolar protein homolog B (Chlamydomonas) GALNT4|POC1B 1,3170023 1,0117838 1,3533275 1,6778314

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5) GALNT5 -1,2782583 -2,3041582 -2,0162926 -2,7784355

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7) GALNT7 1,1362591 -1,7875447 -1,6619025 -1,5640752

UDP-N-acteylglucosamine pyrophosphorylase 1 UAP1 1,3257062 1,3967906 1,9878225 2,729111 unc-5 homolog B (C. elegans) UNC5B 1,0789605 -2,0896275 -1,6763054 -1,5350606 unc-51-like kinase 4 (C. elegans) ULK4 1,1318729 -1,6852689 1,0192232 1,1669306 uncoupling protein 2 (mitochondrial, proton carrier) UCP2 1,0617359 -2,8908412 -1,2544218 1,0243915 uridine phosphorylase 1 UPP1 -1,0213856 1,3359294 1,4434761 2,0887733 uridine-cytidine kinase 2 UCK2 2,0744057 2,7932193 1,9824542 1,559794 uronyl-2-sulfotransferase UST 1,1949311 -1,9620471 -1,2964573 -1,4397162 urothelial cancer associated 1 (non-protein coding) UCA1 -2,6447904 -4,466691 -4,773782 -3,618558

UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast) UTP11L 1,0728735 1,1522825 1,251551 1,5461831

UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) UTP14A 1,2788537 1,5121622 1,2538697 1,2741238 uveal autoantigen with coiled-coil domains and ankyrin repeats UACA 1,3556877 1,424719 1,2930534 1,5798867 v-abl Abelson murine leukemia viral oncogene homolog 2 ABL2 1,3138814 1,160526 1,2128983 1,7465174 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) ERBB3 -1,4722567 -2,6580205 -1,3902392 -1,4101948 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) ETS2 1,6621399 1,8445542 1,8734083 2,1599474 v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) MAF -1,6399021 -2,1412518 -1,3210869 -1,259397 v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) MAFB 1,114792 1,1810062 1,5091958 1,2113935 v-myc myelocytomatosis viral oncogene homolog (avian) MYC 3,1839535 1,8939524 1,8559263 1,9005053 v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) opposite strand MYCNOS -1,7258359 1,1472734 -1,038203 1,1453328 v-ral simian leukemia viral oncogene homolog A (ras related) RALA 1,2491268 1,5071317 1,3748301 1,5256174 v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) RALB 1,0069977 -1,0353293 1,4352853 1,6205769 v-rel reticuloendotheliosis viral oncogene homolog (avian) REL -1,1868496 -1,8841499 -1,7040838 -1,5645524

V-set and immunoglobulin domain containing 1 VSIG1 -1,374682 1,1602074 1,9712037 1,7081461

V-set and immunoglobulin domain containing 10 VSIG10 -1,1896313 -2,113111 -1,2902832 -1,2740282

V-set domain containing T cell activation inhibitor 1 VTCN1 -1,1735232 -1,0374186 -2,3508484 -2,0125973 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 v-yes-1 Yamaguchi sarcoma viral related oncogene homolog LYN 1,209442 3,7783842 3,6402836 4,3190413 vacuolar protein sorting 37 homolog B (S. cerevisiae) VPS37B 1,2243772 1,1662624 1,4326093 1,6016318

VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa VAPA 1,1461155 1,2222725 1,3549433 1,5758563 vang-like 1 (van gogh, Drosophila) VANGL1 -1,0648059 -1,5666182 -1,2037582 -1,0196272 vang-like 2 (van gogh, Drosophila) VANGL2 -1,1024048 -1,7923551 -1,2171402 -1,183191 vascular endothelial growth factor A VEGFA -1,4836864 1,549925 2,4855075 3,3361232 vasoactive intestinal peptide receptor 1 VIPR1 -1,176992 -2,6619804 -1,9937307 -2,2618663 vasoactive intestinal peptide receptor 2 VIPR2 1,0796986 1,6529732 1,3042222 1,2809296 vault RNA 1-3 VTRNA1-3 1,2513413 1,6604437 1,7724766 1,7474996 versican VCAN -1,0162265 1,0352315 1,5126871 1,4165133 very low density lipoprotein receptor VLDLR -1,3689549 1,4476553 2,4012964 2,4660716 vesicle transport through interaction with t-SNAREs homolog 1A (yeast) VTI1A 1,0527389 -1,5131576 -1,0484221 1,0931771 vesicle-associated membrane protein 1 (synaptobrevin 1) | TAP binding protein-like VAMP1|TAPBPL -1,113048 -1,8488004 -1,5028961 -1,6048701 vesicle-associated membrane protein 2 (synaptobrevin 2) VAMP2 1,0034354 -1,1745391 -1,4818457 -1,5564029 vestigial like 1 (Drosophila) VGLL1 -1,2537222 -1,060488 -1,6561975 -2,242438 vestigial like 3 (Drosophila) VGLL3 1,067778 -1,4709566 -1,634244 -1,5162597 von Willebrand factor A domain containing 5A VWA5A -1,0083648 1,1806798 1,9606754 2,0158486

WAP four-disulfide core domain 11 WFDC11 1,0827955 -2,736647 -1,6567713 -1,6203347

WAP four-disulfide core domain 2 WFDC2 1,0829749 1,2301903 1,6258614 1,3626562

WAP four-disulfide core domain 5 WFDC5 -1,1940563 -1,5335677 1,0833651 1,0749091

WD and tetratricopeptide repeats 1 WDTC1 -1,0848292 -1,5257334 -1,249169 -1,1153139

WD repeat domain 12 WDR12 1,1754836 1,6633995 1,481031 1,3774135

WD repeat domain 19 WDR19 1,1071166 -1,5240378 -1,0543978 -1,0053884

WD repeat domain 3 WDR3 1,238184 1,5440505 1,1482252 1,2343773

WD repeat domain 33 WDR33 -1,0613056 -1,633778 1,0006368 -1,5155977

WD repeat domain 43 WDR43 1,3905526 1,6289188 1,4427439 1,5160887

WD repeat domain 47 WDR47 -1,112326 -2,132762 -1,6276282 -1,8387995

WD repeat domain 52 WDR52 1,0156392 -1,8505936 -1,2189769 1,0019616

WD repeat domain 52 WDR52 1,2438776 -1,8816202 -1,346571 -1,6912657

WD repeat domain 66 WDR66 -1,5554376 -1,0974377 -1,0033282 -1,1544303

WD repeat domain 74 WDR74 1,1883875 1,8151783 1,3097633 1,3884263

WD repeat domain 77 WDR77 1,4759239 1,581592 1,2376459 1,1661402

WD repeat domain 91 WDR91 1,5284947 1,5060794 1,806307 2,1105983

WD repeat, sterile alpha motif and U-box domain containing 1 WDSUB1 -1,07971 -1,6759436 -1,1435096 -1,0715783 wingless-type MMTV integration site family, member 10A WNT10A -1,3180552 -2,9080498 -2,3374903 -2,516751 wingless-type MMTV integration site family, member 16 WNT16 1,0647401 1,7060376 1,4860642 1,1131296 wingless-type MMTV integration site family, member 4 WNT4 -1,3936511 -3,9898171 -2,3985178 -3,5338058 wingless-type MMTV integration site family, member 5A WNT5A 1,2662112 -1,1720924 1,0316617 1,563487 wingless-type MMTV integration site family, member 7B WNT7B -1,2159175 -1,5544257 1,0925815 1,0869424 wingless-type MMTV integration site family, member 9A WNT9A -1,0050611 -1,2722406 -1,5383463 -1,5194834

WNK lysine deficient protein kinase 2 WNK2 -1,0966334 -1,0121762 -1,3270811 -1,8395599

WW and C2 domain containing 1 WWC1 2,221243 2,8980505 2,487998 2,7658472

WW domain binding protein 2 WBP2 -1,018153 -1,1988927 1,1762422 1,5518112

WW domain containing E3 ubiquitin protein ligase 1 WWP1 -1,0135349 -1,4378616 -1,5266544 -1,3475277

WW domain containing oxidoreductase WWOX 1,1894343 -1,1272613 -1,5109931 -1,3736314

WW domain containing transcription regulator 1 WWTR1 1,3703406 1,73437 1,378595 1,3360107

X-box binding protein 1 XBP1 1,1550164 1,8292655 1,5611236 1,4057664

X-linked inhibitor of apoptosis XIAP 1,6020601 1,148177 1,31915 1,5531993 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31

X-ray repair complementing defective repair in Chinese hamster cells 4 XRCC4 -1,0571896 -1,1804364 1,557502 1,2944928 xanthine dehydrogenase XDH 1,7739922 3,3805075 2,3811522 2,483893 xenotropic and polytropic retrovirus receptor 1 XPR1 1,0346322 2,36747 1,6037136 1,4324086

XIAP associated factor 1 XAF1 1,1736846 1,3108113 1,1902515 2,3488097

XK, Kell blood group complex subunit-related, X-linked XKRX -1,060243 -1,394918 -1,073225 -1,5401992

YEATS domain containing 2 YEATS2 -1,7331241 -1,1138675 -1,0498899 1,0712419 yippee-like 2 (Drosophila) YPEL2 1,7607374 -1,0343231 1,3599746 1,4392909

Zic family member 5 (odd-paired homolog, Drosophila) ZIC5 -1,0127852 1,6738302 1,003563 -1,0843663 zinc finger and BTB domain containing 1 ZBTB1 1,0091347 -1,5006658 -1,0711222 1,0182687 zinc finger and BTB domain containing 34 ZBTB34 1,0846392 -1,6282411 -1,0418726 -1,0264565 zinc finger and BTB domain containing 7C ZBTB7C 1,0559568 -1,7140543 -1,5574923 -1,2975959 zinc finger and SCAN domain containing 16 ZSCAN16 -1,1138952 -1,479722 -1,7523522 -1,4271607 zinc finger protein 117 | endogenous retroviral sequence 3 ZNF117|ERV3 -1,004788 -1,8821363 -1,617121 -1,2198288 zinc finger protein 138 ZNF138 -1,0362455 -1,8760474 -1,2827212 -1,0625906 zinc finger protein 165 ZNF165 -1,2423102 -1,2866098 1,8468168 1,8694769 zinc finger protein 185 (LIM domain) ZNF185 -1,4194096 -1,7016377 -1,2445389 -1,0631176 zinc finger protein 204, pseudogene ZNF204P -1,0377107 -1,9082769 -1,7282357 -1,1349349 zinc finger protein 215 ZNF215 1,2235194 1,1946081 1,0624509 1,5956717 zinc finger protein 217 ZNF217 1,7413477 1,2455039 1,1086073 1,149106 zinc finger protein 248 ZNF248 1,0841248 -1,5093615 -1,1555766 -1,1085407 zinc finger protein 277 ZNF277 1,1089269 -1,5079229 -1,080223 1,2891569 zinc finger protein 292 ZNF292 -1,1745461 -1,5462992 -1,1916813 -1,0704341 zinc finger protein 318 ZNF318 -1,0406233 -1,5621285 -1,3346893 -1,2194737 zinc finger protein 323 ZNF323 1,2018099 -1,8873074 -1,4692417 -1,1942501 zinc finger protein 33A ZNF33A -1,1002786 -1,5645422 -1,25367 -1,0836746 zinc finger protein 33B ZNF33B -1,0899183 -1,5581576 -1,2744422 1,0480046 zinc finger protein 36, C3H type, homolog (mouse) ZFP36 2,2970402 3,3259997 2,9268453 2,444934 zinc finger protein 385A ZNF385A -1,2438436 -1,6038218 -1,0097132 -1,2633526 zinc finger protein 42 homolog (mouse) ZFP42 -1,3563354 -1,3629693 -1,5185888 -1,3055942 zinc finger protein 431 ZNF431 -1,0023153 -1,6409485 -1,3614358 -1,2804478 zinc finger protein 439 ZNF439 -1,5087829 -1,099267 1,0833901 1,1305997 zinc finger protein 44 ZNF44 -1,0598415 -1,5565953 -1,4236847 -1,2804596 zinc finger protein 443 ZNF443 1,0395339 -1,5079857 -1,1560568 1,4126112 zinc finger protein 462 ZNF462 1,2369698 -1,0983428 -1,2286885 -1,6582922 zinc finger protein 487, pseudogene ZNF487P -1,3440542 -1,6159973 1,0039843 -1,507182 zinc finger protein 488 ZNF488 -1,0739577 -1,3484554 -1,8913151 -1,9989446 zinc finger protein 518A ZNF518A 1,1307377 -1,5090069 -1,2123792 -1,0141646 zinc finger protein 594 ZNF594 -1,0160397 -1,543499 -1,7761002 -1,013997 zinc finger protein 630 ZNF630 -1,1211616 -1,2257636 -1,1899196 -1,5658556 zinc finger protein 652 ZNF652 -1,1184605 -1,5460968 -1,2450001 -1,1113404 zinc finger protein 675 ZNF675 -1,4336538 -1,630601 -1,2610614 -1,1963507 zinc finger protein 678 ZNF678 1,1375284 -1,5745475 -1,1128104 -1,2680372 zinc finger protein 682 ZNF682 -1,2883433 -1,6484301 1,0589328 -1,208813 zinc finger protein 704 ZNF704 1,2353319 -1,1970437 -2,0558267 -1,9256175 zinc finger protein 706 ZNF706 -1,0880196 -1,651752 -1,3673699 -1,2471484 zinc finger protein 737 ZNF737 -1,0355748 -1,8473101 -1,0379862 -1,04963 zinc finger protein 750 ZNF750 -1,6884251 -1,8343433 -1,1212876 -1,0796782 zinc finger protein 766 ZNF766 1,0613271 -1,5955968 -1,0551376 1,014854 Gene name Gene Symbol 2h IL31 8h IL-31 24h IL31 48h IL31 zinc finger protein 808 ZNF808 1,0206947 -1,6275997 -1,3220369 -1,3921273 ZNF814|ZNF552| zinc finger protein 814 | zinc finger protein 552 | zinc finger protein 587 ZNF587 1,3811668 1,0252721 -1,4424284 1,5603529 zinc finger protein 828 ZNF828 1,2965511 1,433759 1,4587836 1,7003402 zinc finger protein 83 ZNF83 -1,0719937 -1,618777 -1,435495 -1,1190965 zinc finger protein 837 ZNF837 -1,1012944 1,1623645 -1,1341062 -1,5132462 zinc finger protein 841 ZNF841 -1,0994945 -1,5051141 -1,1839424 1,0853976 zinc finger protein 845 ZNF845 -1,098228 -1,6281765 -1,0103399 1,2542224 zinc finger protein 846 ZNF846 -1,001448 -1,842703 -1,1966311 -1,0350516 zinc finger protein 860 ZNF860 1,1708647 1,1053411 1,5189291 1,7272215 zinc finger with UFM1-specific peptidase domain ZUFSP 1,1997957 -1,0310328 1,1827428 1,5148896 zinc finger, CCHC domain containing 14 ZCCHC14 -1,0100931 -1,6595093 -1,1192186 -1,060366 zinc finger, DHHC-type containing 13 ZDHHC13 -1,0440295 -1,5397508 -1,4123087 -1,7577841 zinc finger, DHHC-type containing 3 ZDHHC3 1,050128 -1,6039076 -1,3470602 -1,3236458 zinc finger, MYM-type 2 ZMYM2 -1,1387066 -1,5334481 -1,1579574 -1,1455952 zona pellucida-like domain containing 1 ZPLD1 1,2128181 1,1351128 1,378666 1,5356605

ZXD family zinc finger C ZXDC 1,0013597 -1,5372835 -1,2700669 -1,0109829 zymogen granule protein 16 homolog B (rat) ZG16B 1,1514366 -1,1195774 -1,6300099 -1,7115154 zyxin ZYX 1,0266035 1,0861552 1,1585829 1,5076