DOCSLIB.ORG

Toxicological Profile for Selenium

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Toxicological Profile for Selenium TOXICOLOGICAL PROFILE FOR SELENIUM U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service Agency for Toxic Substances and Disease Registry September 2003 SELENIUM ii DISCLAIMER The use of company or product name(s) is for identification only and does not imply endorsement by the Agency for Toxic Substances and Disease Registry. SELENIUM iii UPDATE STATEMENT A Toxicological Profile for selenium, Draft for Public Comment was released in September, 2001. This edition supersedes any previously released draft or final profile. Toxicological profiles are revised and republished as necessary, but no less than once every three years. For information regarding the update status of previously released profiles, contact ATSDR at: Agency for Toxic Substances and Disease Registry Division of Toxicology/Toxicology Information Branch 1600 Clifton Road NE, Mailstop E-29 Atlanta, Georgia 30333 SELENIUM vii QUICK REFERENCE FOR HEALTH CARE PROVIDERS Toxicological Profiles are a unique compilation of toxicological information on a given hazardous substance. Each profile reflects a comprehensive and extensive evaluation, summary, and interpretation of available toxicologic and epidemiologic information on a substance. Health care providers treating patients potentially exposed to hazardous substances will find the following information helpful for fast answers to often-asked questions. Primary Chapters/Sections of Interest Chapter 1: Public Health Statement: The Public Health Statement can be a useful tool for educating patients about possible exposure to a hazardous substance. It explains a substance’s relevant toxicologic properties in a nontechnical, question-and-answer format, and it includes a review of the general health effects observed following exposure. Chapter 2: Relevance to Public Health: The Relevance to Public Health Section evaluates, interprets, and assesses the significance of toxicity data to human health. Chapter 3: Health Effects: Specific health effects of a given hazardous compound are reported by type of health effect (death, systemic, immunologic, reproductive), by route of exposure, and by length of exposure (acute, intermediate, and chronic). In addition, both human and animal studies are reported in this section. NOTE: Not all health effects reported in this section are necessarily observed in the clinical setting. Please refer to the Public Health Statement to identify general health effects observed following exposure. Pediatrics: Four new sections have been added to each Toxicological Profile to address child health issues: Section 1.6 How Can (Chemical X) Affect Children? Section 1.7 How Can Families Reduce the Risk of Exposure to (Chemical X)? Section 3.7 Children’s Susceptibility Section 6.6 Exposures of Children Other Sections of Interest: Section 3.8 Biomarkers of Exposure and Effect Section 3.11 Methods for Reducing Toxic Effects ATSDR Information Center Phone: 1-888-42-ATSDR or (404) 498-0110 Fax: (404) 498-0093 E-mail: [email protected] Internet: http://www.atsdr.cdc.gov The following additional material can be ordered through the ATSDR Information Center: Case Studies in Environmental Medicine: Taking an Exposure History—The importance of taking an exposure history and how to conduct one are described, and an example of a thorough exposure history is provided. Other case studies of interest include Reproductive and Developmental Hazards; Skin Lesions and Environmental Exposures; Cholinesterase-Inhibiting Pesticide Toxicity; and numerous chemical-specific case studies. SELENIUM viii Managing Hazardous Materials Incidents is a three-volume set of recommendations for on-scene (prehospital) and hospital medical management of patients exposed during a hazardous materials incident. Volumes I and II are planning guides to assist first responders and hospital emergency department personnel in planning for incidents that involve hazardous materials. Volume III— Medical Management Guidelines for Acute Chemical Exposures—is a guide for health care professionals treating patients exposed to hazardous materials. Fact Sheets (ToxFAQs) provide answers to frequently asked questions about toxic substances. Other Agencies and Organizations The National Center for Environmental Health (NCEH) focuses on preventing or controlling disease, injury, and disability related to the interactions between people and their environment outside the workplace. Contact: NCEH, Mailstop F-29, 4770 Buford Highway, NE, Atlanta, GA 30341­ 3724 • Phone: 770-488-7000 • FAX: 770-488-7015. The National Institute for Occupational Safety and Health (NIOSH) conducts research on occupational diseases and injuries, responds to requests for assistance by investigating problems of health and safety in the workplace, recommends standards to the Occupational Safety and Health Administration (OSHA) and the Mine Safety and Health Administration (MSHA), and trains professionals in occupational safety and health. Contact: NIOSH, 200 Independence Avenue, SW, Washington, DC 20201 • Phone: 800-356-4674 or NIOSH Technical Information Branch, Robert A. Taft Laboratory, Mailstop C-19, 4676 Columbia Parkway, Cincinnati, OH 45226-1998 • Phone: 800-35-NIOSH. The National Institute of Environmental Health Sciences (NIEHS) is the principal federal agency for biomedical research on the effects of chemical, physical, and biologic environmental agents on human health and well-being. Contact: NIEHS, PO Box 12233, 104 T.W. Alexander Drive, Research Triangle Park, NC 27709 • Phone: 919-541-3212. Referrals The Association of Occupational and Environmental Clinics (AOEC) has developed a network of clinics in the United States to provide expertise in occupational and environmental issues. Contact: AOEC, 1010 Vermont Avenue, NW, #513, Washington, DC 20005 • Phone: 202-347-4976 • FAX: 202-347-4950 • e-mail: [email protected] • Web Page: http://www.aoec.org/. The American College of Occupational and Environmental Medicine (ACOEM) is an association of physicians and other health care providers specializing in the field of occupational and environmental medicine. Contact: ACOEM, 55 West Seegers Road, Arlington Heights, IL 60005 • Phone: 847-818-1800 • FAX: 847-818-9266. SELENIUM ix CONTRIBUTORS CHEMICAL MANAGER(S)/AUTHOR(S): John Risher, Ph.D. ATSDR, Division of Toxicology, Atlanta, GA A. Rosa McDonald, Ph.D. Mario J. Citra, Ph.D. Stephen Bosch, B.S. Richard J. Amata, M.S. Syracuse Research Corporation, North Syracuse, NY THE PROFILE HAS UNDERGONE THE FOLLOWING ATSDR INTERNAL REVIEWS: 1. Health Effects Review. The Health Effects Review Committee examines the health effects chapter of each profile for consistency and accuracy in interpreting health effects and classifying end points. 2. Minimal Risk Level Review. The Minimal Risk Level Workgroup considers issues relevant to substance-specific minimal risk levels (MRLs), reviews the health effects database of each profile, and makes recommendations for derivation of MRLs. 3. Data Needs Review. The Research Implementation Branch reviews data needs sections to assure consistency across profiles and adherence to instructions in the Guidance. SELENIUM xi PEER REVIEW A peer review panel was assembled for selenium. The panel consisted of the following members: 1. Orville Levander, Ph.D., Silver Springs, Maryland 2. Gregory Möller, Ph.D., Associate Professor of Environmental Chemistry and Toxicology, Moscow, Indiana 3. Raghubir Sharma, Ph.D., D.V.M., Professor of Physiology and Pharmacology, Athens, Georgia These experts collectively have knowledge of selenium's physical and chemical properties, toxicokinetics, key health end points, mechanisms of action, human and animal exposure, and quantification of risk to humans. All reviewers were selected in conformity with the conditions for peer review specified in Section 104(I)(13) of the Comprehensive Environmental Response, Compensation, and Liability Act, as amended. Scientists from the Agency for Toxic Substances and Disease Registry (ATSDR) have reviewed the peer reviewers' comments and determined which comments will be included in the profile. A listing of the peer reviewers' comments not incorporated in the profile, with a brief explanation of the rationale for their exclusion, exists as part of the administrative record for this compound. A list of databases reviewed and a list of unpublished documents cited are also included in the administrative record. The citation of the peer review panel should not be understood to imply its approval of the profile's final content. The responsibility for the content of this profile lies with the ATSDR. SELENIUM xiii CONTENTS FOREWORD ................................................................................................................................................v CONTRIBUTORS.......................................................................................................................................ix PEER REVIEW ...........................................................................................................................................xi LIST OF FIGURES ..................................................................................................................................xvii LIST OF TABLES.....................................................................................................................................xix 1. PUBLIC HEALTH STATEMENT..........................................................................................................1 1.1 WHAT IS SELENIUM?..............................................................................................................1
Load more

Recommended publications
  • Remote Sensing and Airborne Geophysics in the Assessment of Natural Aggregate Resources
    U. S. DEPARTMENT OF THE INTERIOR U. S. GEOLOGICAL SURVEY REMOTE SENSING AND AIRBORNE GEOPHYSICS IN THE ASSESSMENT OF NATURAL AGGREGATE RESOURCES by D.H. Knepper, Jr.1, W.H. Langer1, and S.H. Miller1 OPEN-FILE REPORT 94-158 1994 This report is preliminary and has not been reviewed for conformity with U.S. Geological Survey editorial standards. Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government. 1U.S. Geological Survey, Denver, CO 80225 CONTENTS ABSTRACT........................................................................................... iv CHAPTER I. INTRODUCTION.............................................................................. I-1 II. TYPES OF AGGREGATE DEPOSITS........................................... II-1 Crushed Stone............................................................................... II-1 Sedimentary Rocks............................................................. II-3 Igneous Rocks.................................................................... II-3 Metamorphic Rocks........................................................... II-4 Sand and Gravel............................................................................ II-4 Glacial Deposits................................................................ II-5 Alluvial Fans.................................................................... II-5 Stream Channel and Terrace Deposits............................... II-6 Marine Deposits...............................................................
    [Show full text]
  • Selenium Nutritional, Toxicologic, and Clinical Aspects ANNA M
    160 Articles Selenium Nutritional, Toxicologic, and Clinical Aspects ANNA M. FAN, PhD, Berkeley, and KENNETH W. KIZER, MD, MPH, Sacramento, California This is one ofa series ofarticles from western state public health departments. Despite the recent findings ofenvironmental contamination, selenium toxicosis in humans is exceedingly rare in the United States, with the few known cases resulting from industrial accidents and an episode involving the ingestion of superpotent selenium supplements. Chronic selenosis is essentially unheard of in this country because of the typical diversity of the American diet. Nonetheless, because ofthe growing public interest in selenium as a dietary supplement and the occurrence ofenvironmental selenium contamination, medical practitioners should be familiar with the nutritional, toxicologic, and clinical aspects of this trace element. (Fan AM, Kizer KW: Selenium-Nutritional, toxicologic, and clinical aspects. West J Med 1990 Aug; 153:160-167) Since the recognition of the nutritional essentiality of and other parts of the world.4 Highly seleniferous soils selenium (Se) in animals in 1957, there has been ever- yielding selenium-toxic plants (such as Astragalus bisulca- increasing interest in this trace element. This interest has tus) are widespread in South Dakota, Wyoming, Montana, heightened in the past decade concomitant with the recog- North Dakota, Nebraska, Kansas, Colorado, Utah, Arizona, nition of selenium's essential nutritional role in humans and New Mexico. Soil containing high selenium concentra- and reports of selenium toxicity among humans. Interest in tions but not yielding toxic plants is found in Hawaii. selenium has been further aroused recently by the findings of elevated levels of this compound in certain soils and wa- Chemical Forms ter sources in the western United States, leading to adverse Selenium is a nonmetallic element chemically related to effects on fish and wildlife (T.
    [Show full text]
  • The Electronic and Optical Properties of Close Packed Cadmium Selenide Quantum Dot Solids
    The Electronic and Optical Properties of Close Packed Cadmium Selenide Quantum Dot Solids by Cherie Renee Kagan B. S. E. Materials Science and Engineering B. A. Mathematics University of Pennsylvania, Philadelphia, PA 1991 Submitted to the Department of Materials Science and Engineering in Partial Fulfillment of the Requirements for the Degree of DOCTOR OF PHILOSOPHY at the MASSACHUSETTS INSTITUTE OF TECHNOLOGY September 1996 0 1996 Massachusetts Institute of Technology All rights reserved Signature of the Author Departmenf of Materials Science and Engineering August 9, 1996 Certified by_ Moungi G. Bawendi Professor of Chemistry Thesis Supervisor Accepted by Linn W. Hobbs John F. Elliott Professor of Materials Science and Engineering Chair, Department Committee on Graduate Students AROHIvES ()F Tac(.!-otodY SEP 2 71996 Room 14-0551 77 Massachusetts Avenue Cambridge, MA 02139 Ph: 617.253.2800 MITLbries Email: [email protected] Document Services http://Iibraries.mit.eduldocs DISCLAIMER OF QUALITY Due to the condition of the original material, there are unavoidable flaws in this reproduction. We have made every effort possible to provide you with the best copy available. If you are dissatisfied with this product and find it unusable, please contact Document Services as soon as possible. Thank you. The images contained in this document are of the best quality available. 2 3 The Electronic and Optical Properties of Close Packed Cadmium Selenide Quantum Dot Solids by Cherie Renee Kagan - Submitted to the Department of Materials Science and Engineering on August 9, 1996 in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy in Materials Science and Engineering Abstract The synthesis, structural characterization, optical spectroscopy, and electronic characterization of close packed solids prepared from CdSe QD samples tunable in size from 17 to 150 A in diameter (a<4.5%) are presented.
    [Show full text]
  • Wind Through the Buffalo Grass: a Lakota Story Cycle Paul A
    University of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln Paul Johnsgard Collection Papers in the Biological Sciences 2008 Wind Through the Buffalo Grass: A Lakota Story Cycle Paul A. Johnsgard University of Nebraska-Lincoln, [email protected] Follow this and additional works at: http://digitalcommons.unl.edu/johnsgard Part of the Indigenous Studies Commons, Other Languages, Societies, and Cultures Commons, and the Terrestrial and Aquatic Ecology Commons Johnsgard, Paul A., "Wind Through the Buffalo Grass: A Lakota Story Cycle" (2008). Paul Johnsgard Collection. 51. http://digitalcommons.unl.edu/johnsgard/51 This Article is brought to you for free and open access by the Papers in the Biological Sciences at DigitalCommons@University of Nebraska - Lincoln. It has been accepted for inclusion in Paul Johnsgard Collection by an authorized administrator of DigitalCommons@University of Nebraska - Lincoln. Fiction I Historical History I Native Ameri("an Wind Through the Buffalo Grass: A Lakota Story Cycle is a narrative history of the Pine Ridge Lakota tribe of South Dakota, following its history from 1850 to the present day through actual historical events and through the stories of four fictional Lakota children, each related by descent and separated from one another by two generations. The ecology of the Pine Ridge region, especially its mammalian and avian wildlife, is woven into the stories of the children. 111ustrated by the author, the book includes drawings of Pine Ridge wildlife, regional maps, and Native American pictorial art. Appendices include a listing of important Lakota words, and checklists of mammals and breeding birds of the region. Dr. Paul A. Johnsgard is foundation professor of biological sciences emeritus of the University of Nebraska-lincoln.
    [Show full text]
  • Research Article Combined Treatment with Myo-Inositol and Selenium Ensures Euthyroidism in Subclinical Hypothyroidism Patients with Autoimmune Thyroiditis
    Hindawi Publishing Corporation Journal of Thyroid Research Volume 2013, Article ID 424163, 5 pages http://dx.doi.org/10.1155/2013/424163 Research Article Combined Treatment with Myo-Inositol and Selenium Ensures Euthyroidism in Subclinical Hypothyroidism Patients with Autoimmune Thyroiditis Maurizio Nordio1 and Raffaella Pajalich2 1 University of Rome “Sapienza”, Institute of Gynecology and Obstetrics, Viale del Policlinico, 00155 Rome, Italy 2 Ars Medica spa, Via Ferrero di Cambiano Cesare 29, 00191 Rome, Italy Correspondence should be addressed to Maurizio Nordio; [email protected] Received 8 May 2013; Revised 27 August 2013; Accepted 27 August 2013 Academic Editor: Jack R. Wall Copyright © 2013 M. Nordio and R. Pajalich. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Hashimoto’s thyroiditis (HT), also known as chronic lymphocytic thyroiditis or chronic autoimmune thyroiditis, is the most common form of thyroiditis affecting more than 10% of females and 2% of males. The present study aims to evaluate the beneficial effect of a combined treatment, Myo-Inositol plus selenomethionine, on subclinical hypothyroidism. Methods. The study was designed as a double-blind randomized controlled trial. Eligible patients were women diagnosed with subclinical hypothyroidism having Tg antibodies (TgAb) titer higher than 350 IU/mL. Outcome measures were Thyroid Stimulating Hormone (TSH) levels, thyroid peroxidase antibodies (TPOAb) and TgAb titer, selenium, and Myo-Inositol plasma concentration. Results. In the present paper, we demonstrated that the beneficial effects obtained by selenomethionine treatment on patients affected by subclinical hypothyroidism, likely due to the presence of autoantibody (TPOAb and TgAb), are further improved by cotreatment with Myo-Inositol.
    [Show full text]
  • The Management of Common Skin Conditions in General Practice
    Management of Common Skin Conditions In General Practice including the “red rash made easy” © Arroll, Fishman & Oakley, Department of General Practice and Primary Health Care University of Auckland, Tamaki Campus Reviewed by Hon A/Prof Amanda Oakley - 2019 http://www.dermnetnz.org Management of Common Skin Conditions In General Practice Contents Page Derm Map 3 Classic location: infants & children 4 Classic location: adults 5 Dermatology terminology 6 Common red rashes 7 Other common skin conditions 12 Common viral infections 14 Common bacterial infections 16 Common fungal infections 17 Arthropods 19 Eczema/dermatitis 20 Benign skin lesions 23 Skin cancers 26 Emergency dermatology 28 Clinical diagnosis of melanoma 31 Principles of diagnosis and treatment 32 Principles of treatment of eczema 33 Treatment sequence for psoriasis 34 Topical corticosteroids 35 Combination topical steroid + antimicrobial 36 Safety with topical corticosteroids 36 Emollients 37 Antipruritics 38 For further information, refer to: http://www.dermnetnz.org And http://www.derm-master.com 2 © Arroll, Fishman & Oakley, Department of General Practice and Primary Health Care, University of Auckland, Tamaki Campus. Management of Common Skin Conditions In General Practice DERM MAP Start Is the patient sick ? Yes Rash could be an infection or a drug eruption? No Insect Bites – Crop of grouped papules with a central blister or scab. Is the patient in pain or the rash Yes Infection: cellulitis / erysipelas, impetigo, boil is swelling, oozing or crusting? / folliculitis, herpes simplex / zoster. Urticaria – Smooth skin surface with weals that evolve in minutes to hours. No Is the rash in a classic location? Yes See our classic location chart .
    [Show full text]
  • Decalin Dehydrogenation for In-Situ Hydrogen Production To
    DECALIN DEHYDROGENATION FOR IN-SITU HYDROGEN PRODUCTION TO INCREASE CATALYTIC CRACKING RATE OF N-DODECANE Thesis Submitted to The School of Engineering of the UNIVERSITY OF DAYTON In Partial Fulfillment of the Requirements for The Degree of Master of Science in Chemical Engineering By Christopher Bruening Dayton, Ohio May, 2018 DECALIN DEHYDROGENATION FOR IN-SITU HYDROGEN PRODUCTION TO INCREASE CATALYTIC CRACKING RATE OF N-DODECANE Name: Bruening, Christopher Robbins APPROVED BY: Matthew J. DeWitt, Ph.D. Donald K. Phelps, Ph.D. Advisory Committee Chairman Committee Member Distinguished Research Engineer Senior Research Chemist University of Dayton Research Institute Air Force Research Laboratory Michael Elsass, Ph.D. Kevin Myers, D.Sc., P.E. Committee Member Committee Member Lecturer Professor Department of Chemical and Materials Department of Chemical and Materials Engineering Engineering Robert J. Wilkens, Ph.D., P.E. Eddy M. Rojas, Ph.D., M.A., P.E. Associate Dean for Research and Innovation Dean, School of Engineering Professor School of Engineering School of Engineering ii ABSTRACT DECALIN DEHYDROGENATION FOR IN-SITU HYDROGEN PRODUCTION TO INCREASE CATALYTIC CRACKING RATE OF N-DODECANE Name: Bruening, Christopher Robbins University of Dayton Advisor: Dr. Matthew J. DeWitt Catalytic cracking of paraffinic hydrocarbons is a widely utilized industrial process, but catalyst deactivation over time requires regeneration or replacement of the catalyst bed. A gaseous hydrogen co-feed can be used to promote hydrocracking and decrease deactivation of the catalyst due to coke formation or active site poisoning. One potential alternative approach to extend the lifetime of a cracking catalyst is to generate molecular hydrogen in-situ via catalytic dehydrogenation of a cycloparaffin.
    [Show full text]
  • Dibasic Acids for Nylon Manufacture
    - e Report No. 75 DIBASIC ACIDS FOR NYLON MANUFACTURE by YEN-CHEN YEN October 1971 A private report by the PROCESS ECONOMICS PROGRAM STANFORD RESEARCH INSTITUTE MENLO PARK, CALIFORNIA CONTENTS INTRODUCTION, ....................... 1 SUMMARY .......................... 3 General Aspects ...................... 3 Technical Aspects ..................... 7 INDUSTRY STATUS ...................... 15 Applications and Consumption of Sebacic Acid ........ 15 Applications and Consumption of Azelaic Acid ........ 16 Applications of Dodecanedioic and Suberic Acids ...... 16 Applications of Cyclododecatriene and Cyclooctadiene .... 17 Producers ......................... 17 Prices ........................... 18 DIBASIC ACIDS FOR MANUFACTURE OF POLYAMIDES ........ 21 CYCLOOLIGOMERIZATIONOF BUTADIENE ............. 29 Chemistry ......................... 29 Ziegler Catalyst ..................... 30 Nickel Catalyst ..................... 33 Other Catalysts ..................... 34 Co-Cyclooligomerization ................. 34 Mechanism ........................ 35 By-products and Impurities ................ 37 Review of Processes .................... 38 A Process for Manufacture of Cyclododecatriene ....... 54 Process Description ................... 54 Process Discussion .................... 60 Cost Estimates ...................... 60 A Process for Manufacture of Cyclooctadiene ........ 65 Process Description ................... 65 Process Discussion .................... 70 Cost Estimates ...................... 70 A Process for Manufacture of Cyclodecadiene
    [Show full text]
  • Mineral Deficiencies in Florida and Supplementation Considerations
    Mineral Deficiencies in Florida and Supplementation Considerations Lee R. McDowell and Mark E. Tiffany Department of Animal Science University of Florida, Gainesville Summary than 100%, to increase growth rates from 10% to 25%, and to reduce mortality significantly Mineral deficiencies have been and continue to (McDowell, 1992; 1997). be severe detriments to beef cattle production in Florida. Historically, Florida cattle have suffered The first United States reports of Cu or Co from deficiencies of P, Ca, Na, Mg, Co, Cu, Zn, deficiency in grazing cattle originated in Florida and toxicities of F and Mo. In more recent years Se (Becker et al., 1965). Nutritional anemia or “salt deficiency, as evidenced by white muscle disease sick” in cattle, later established as a deficiency of and a “buckling” condition, has been widespread. Fe, Cu and Co, was noted as early as 1872 (Becker Evaluating 15 data sets of Florida forages et al., 1965). Prior to the 1950s, Florida’s nutri- (predominately bahiagrass), the minerals most de- tional deficiencies, as evidenced by low forage ficient were P, Na, Cu, Se and Zn, with Ca, Mg and and(or) animal tissue concentration or decreased Co found to be borderline-to-deficient depending on performance, had been established for Ca, P, Co, location, season, forage species, and year. As a Cu, Na, Mg, and Fe. In more recent years the low-cost insurance measure to provide adequate problems of Se and Zn deficiency for ruminants mineral nutrition, a modified “complete” mineral have been observed. Zinc deficiency was evidenced supplement should be available free-choice. The by hair loss and skin lesions.
    [Show full text]
  • List of Union Reference Dates A
    Active substance name (INN) EU DLP BfArM / BAH DLP yearly PSUR 6-month-PSUR yearly PSUR bis DLP (List of Union PSUR Submission Reference Dates and Frequency (List of Union Frequency of Reference Dates and submission of Periodic Frequency of submission of Safety Update Reports, Periodic Safety Update 30 Nov. 2012) Reports, 30 Nov.
    [Show full text]
  • Nutritional Disturbances in Crohn's Disease ANTHONY D
    Postgrad Med J: first published as 10.1136/pgmj.59.697.690 on 1 November 1983. Downloaded from Postgraduate Medical Journal (November 1983) 59, 690-697 Nutritional disturbances in Crohn's disease ANTHONY D. HARRIES RICHARD V. HEATLEY* M.A., M.R.C.P. M.D., M.R.C.P. Department of Gastroenterology, University Hospital of Wales, Cardiffand *Department ofMedicine, St James's University Hospital, Leeds LS9 7TF Summary deficiency in the same patient. The most important A wide range of nutritional disturbances may be causes of malnutrition are probably reduced food found in patients with Crohn's disease. As more intake, active inflammation and enteric loss of sophisticated tests become available to measure nutrients (Dawson, 1972). vitamin and trace element deficiencies, so these are being recognized as complications ofCrohn's disease. TABLE 1. Pathogenesis of malnutrition It is important to recognize nutritional deficiencies at an early stage and initiate appropriate treatment. Reduced food intake Anorexia Otherwise many patients, experiencing what can be a Fear of eating from abdominal pain chronic and debilitating illness, may suffer unneces- Active inflammation Mechanisms unknown Protected by copyright. sarily from the consequences of deprivation of vital Enteric loss of nutrients Exudation from intestinal mucosa nutrients. Interrupted entero-hepatic circulation Malabsorption Loss of absorptive surface from disease, resection or by-pass KEY WORDS: growth disturbance, Crohn's disease, anaemia, vitamin deficiency. Stagnant loop syndrome from strictures, fistulae or surgically created blind loops Introduction Miscellaneous Rapid gastrointestinal transit Effects of medical therapy Crohn's disease is a chronic inflammatory condi- Effects of parenteral nutrition tion ofunknown aetiology that may affect any part of without trace element supplements the gastrointestinal tract from mouth to anus.
    [Show full text]
  • Effect of Testosterone on the Growth and Virulence of Staphylococcus Aureus
    Loyola University Chicago Loyola eCommons Master's Theses Theses and Dissertations 1966 Effect of Testosterone on the Growth and Virulence of Staphylococcus aureus Joseph Lloyd Waner Loyola University Chicago Follow this and additional works at: https://ecommons.luc.edu/luc_theses Part of the Medicine and Health Sciences Commons Recommended Citation Waner, Joseph Lloyd, "Effect of Testosterone on the Growth and Virulence of Staphylococcus aureus" (1966). Master's Theses. 2065. https://ecommons.luc.edu/luc_theses/2065 This Thesis is brought to you for free and open access by the Theses and Dissertations at Loyola eCommons. It has been accepted for inclusion in Master's Theses by an authorized administrator of Loyola eCommons. For more information, please contact [email protected]. This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License. Copyright © 1966 Joseph Lloyd Waner Effect of Testosterone on the Growth and Virulence of Staphlococcus aureus By Joseph L. Waner Microbiology Department Stritch School of Medicine A thesis submitted to the Faculty of the Graduate School of Loyola University in partial fulfillment of the requirements for the degree of Master of Science. TABLE OF CONTENTS Lifv--------------------------------------------- ii Abstract-------------------------------------------P. 1 Introd~ction---------------------------------------P. 2-3 ~a terials and Nethod s------------------- ---------------P. 4-10 S. aureus strains------------ -----------------------P. 4 Testosterone Bolutions------------·------·---------P.
    [Show full text]