Harqua Hala Letters
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REVIEW Signal Transduction, Cell Cycle Regulatory, and Anti
Leukemia (1999) 13, 1109–1166 1999 Stockton Press All rights reserved 0887-6924/99 $12.00 http://www.stockton-press.co.uk/leu REVIEW Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs WL Blalock1, C Weinstein-Oppenheimer1,2, F Chang1, PE Hoyle1, X-Y Wang3, PA Algate4, RA Franklin1,5, SM Oberhaus1,5, LS Steelman1 and JA McCubrey1,5 1Department of Microbiology and Immunology, 5Leo Jenkins Cancer Center, East Carolina University School of Medicine Greenville, NC, USA; 2Escuela de Quı´mica y Farmacia, Facultad de Medicina, Universidad de Valparaiso, Valparaiso, Chile; 3Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, MN, USA; and 4Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA Over the past decade, there has been an exponential increase growth factor), Flt-L (the ligand for the flt2/3 receptor), erythro- in our knowledge of how cytokines regulate signal transduc- poietin (EPO), and others affect the growth and differentiation tion, cell cycle progression, differentiation and apoptosis. Research has focused on different biochemical and genetic of these early hematopoietic precursor cells into cells of the 1–4 aspects of these processes. Initially, cytokines were identified myeloid, lymphoid and erythroid lineages (Table 1). This by clonogenic assays and purified by biochemical techniques. review will concentrate on IL-3 since much of the knowledge This soon led to the molecular cloning of the genes encoding of how cytokines affect cell growth, signal transduction, and the cytokines and their cognate receptors. -
Can't Go Home by Noelle Adams / Pfangirl PART 1
Can't go home By Noelle Adams / pfangirl PART 1 - SUFFOCATED A caged lioness. That's what Lara reminded Sam of now. Every time she looked at her best friend, the American thought of the big cat she'd seen in a German zoo during her globe- trotting childhood. It wouldn't lie still. It was pure feral energy, striding back and forth in its enclosure, muscles rippling beneath its pelt. Lara was the same. Lithe grace and power in human form, always moving, always intensely focused on some task or thing. Almost permanently scowling. Sam had always wondered which of her parents Lara inherited her effortless physicality from. Four years of knowing Lara, and Sam still wasn't sure. There were no photos for her to consult. The young archaeologist hardly spoke about her vanished mother and father. She avoided talking about them; evidently running from their memory like she ran from what had happened on Yamatai. In the one and a half months since the shipwreck – well, at least since she was released from hospital – Lara had been seized by a frantic, feverish vigour. They had travelled from Osaka to the UK, where Lara had spent a single day at her family's estate, ransacking her father's study. From there they headed to New York. This put Lara closer to her next intended stop – Roanoke Island. Although the city was a good base for Lara to work from while she planned her next expedition, there was a second, more distasteful reason for the archaeologist to be there: an exclusive television interview. -
DEKLIM a German Contribution to the IGBP-PAGES Program
PAGES International Project Offi ce Sulgeneckstrasse 38 3007 Bern Switzerland Tel: +41 31 312 31 33 Fax: +41 31 312 31 68 [email protected] Text Editing: Leah Christen News Layout: Christoph Kull Frank Sirocko and Gerrit Lohmann, Guest Editors Circulation: 3400 Christoph Kull and Leah Christen, Editors VOL.12, N°2 – SEPTEMBER 2004 DEKLIM A German Contribution to the IGBP-PAGES Program www.pages-igbp.org Grouping of the 33 DEKLIM-Paleo projects into 13 bundles: This special issue presents results as well as working reports of the ongoing program. A DEKLIM overview is presented in the “Program News” section. Contents 2 Announcements - Climate Change around 117 ka BP - Editorial: DEKLIM Paleo - Climate Transitions: Forcings - Feedbacks - Inside PAGES - Tree Rings, Isotopes and Climate - New on the PAGES Bookshelf - Modeling the Last Glacial Cycle - Global Holocene Climate Variability 4 Program News - Late Glacial Changes in Central Europe - PROPER: Proxies in Paleoclimatology - The Global Carbon Cycle around 20 ka BP - Paleocat: A Catalan Paleo-Network - North Atlantic Coral Climate History - DEKLIM: German Climate Research 33 Workshop Reports 8 National Page - Holocene Climate in the Alps - France - Ethiopia - Holocene Monsoon Variability - India - African Paleoenvironments - Kenya 9 Science Highlights - Climate Change in Southern Patagonia 36 Last Page - Modeling the Atmospheric Circulation - Calendar - Solar Variability and Holocene Climate - The PAGES Product Database - 18O/16O Ratio during Heinrich Event 1 ISSN 1563–0803 The PAGES International Project Offi ce and its publications are supported by the Swiss and US National Science Foundations and NOAA. 2 Announcements Announcements 3 Editorial: DEKLIM - PALEO The results of climate research enjoy a high level of public interest. -
Bingo Carpet
V -A - PAGE TWENTY ■\ THURSDAY, JULY 17, 1969 AYwage Daily Net Press Run lEtiptttng ilf r a li Far The Week Ended June 28. 1666& The Weather les, Simsbury and Evelyn Rob R ockville erts. Prospect St,, Rockville.' Chance o4 scattered thunder Dlschagred Tuesday: Dale PJV.C. 15,459 showers toward evening, ’IV> Hospital Notes Schenk, Mt. Vernon Dr., Rock night cloudy, decreasing hu ville; Frank Mlffltt, Rockville; midity. Low 85 to TO. ’Tbtnor- Visltlniir hours are 12;S0 to 8 Thomas Lee, Franklin Park. MancheMer— 4 City of Village Charm row cloudy, idiowers likely. p.m. in all areas except mater Rockville; i Oliver Johnston, VOL, LXXXVm. MO, 2<5 (TWENTY-POUR PAGES-TWO SECTIONS) nity where they are 2 to 4 and Rockville; Katheryn Pippin, MANCHESTER, CONN., FRIDAY, JULY 18, 1969 6:30 to 8 p.m . ''' (Claaslfled Advertlstiig on Page 20) Broad Brook; B arbara Olen- I ~ ~ ^ ------- ------------ ^-------- PRICE TEN CENTS der, Gehring Rd., Tolland; Admitted Tuesday: Patricia* BINGO Louis Lavltt, Hillsdale Dr., Fournier, Cook Rd., Tolland; EVERY MONDAY-E P.M. Rockville; BMlen Gunther, Rock A Donald Johnson, Rock^lle; ville; Robertha H a^s, Rock 26 VILLAGE STREET, ROCKVILLE Apollo TV Schedule George Allen, Rt. 2, Tolland; ville, and Kathleen Duval, Vil P. A. C. BALLROOM NEW YORK (AP)—F^low- Vernon ;n-ald lage St,, RockvHle. Scott Tetro, Broad Brook; Mar Honduras Charges ing are the television s^ed- jorie Nelson, Tankerhoosan ules of major networiu for A liquor company In Peoria. Apollo 11 coverage; Birth Control Advice Rd., Vernon; John Bemache, 111., produces up to 1,500,000 bot ThompsonvlUe; Josephine Rob Read Herald Advertisements BMday : Live color trans- tles of liquor a day. -
ICD-9 Diagnosis Codes Effective 10/1/2011 (V29.0) Source: Centers for Medicare and Medicaid Services
ICD-9 Diagnosis Codes effective 10/1/2011 (v29.0) Source: Centers for Medicare and Medicaid Services 0010 Cholera d/t vib cholerae 00801 Int inf e coli entrpath 01086 Prim prg TB NEC-oth test 0011 Cholera d/t vib el tor 00802 Int inf e coli entrtoxgn 01090 Primary TB NOS-unspec 0019 Cholera NOS 00803 Int inf e coli entrnvsv 01091 Primary TB NOS-no exam 0020 Typhoid fever 00804 Int inf e coli entrhmrg 01092 Primary TB NOS-exam unkn 0021 Paratyphoid fever a 00809 Int inf e coli spcf NEC 01093 Primary TB NOS-micro dx 0022 Paratyphoid fever b 0081 Arizona enteritis 01094 Primary TB NOS-cult dx 0023 Paratyphoid fever c 0082 Aerobacter enteritis 01095 Primary TB NOS-histo dx 0029 Paratyphoid fever NOS 0083 Proteus enteritis 01096 Primary TB NOS-oth test 0030 Salmonella enteritis 00841 Staphylococc enteritis 01100 TB lung infiltr-unspec 0031 Salmonella septicemia 00842 Pseudomonas enteritis 01101 TB lung infiltr-no exam 00320 Local salmonella inf NOS 00843 Int infec campylobacter 01102 TB lung infiltr-exm unkn 00321 Salmonella meningitis 00844 Int inf yrsnia entrcltca 01103 TB lung infiltr-micro dx 00322 Salmonella pneumonia 00845 Int inf clstrdium dfcile 01104 TB lung infiltr-cult dx 00323 Salmonella arthritis 00846 Intes infec oth anerobes 01105 TB lung infiltr-histo dx 00324 Salmonella osteomyelitis 00847 Int inf oth grm neg bctr 01106 TB lung infiltr-oth test 00329 Local salmonella inf NEC 00849 Bacterial enteritis NEC 01110 TB lung nodular-unspec 0038 Salmonella infection NEC 0085 Bacterial enteritis NOS 01111 TB lung nodular-no exam 0039 -
Evidence from Opportunity's Microscopic Imager for Water on Meridiani Planum K
Evidence from Opportunity's Microscopic Imager for Water on Meridiani Planum K. E. Herkenhoff, et al. Science 306, 1727 (2004); DOI: 10.1126/science.1105286 This copy is for your personal, non-commercial use only. If you wish to distribute this article to others, you can order high-quality copies for your colleagues, clients, or customers by clicking here. Permission to republish or repurpose articles or portions of articles can be obtained by following the guidelines here. The following resources related to this article are available online at www.sciencemag.org (this infomation is current as of October 27, 2011 ): Updated information and services, including high-resolution figures, can be found in the online version of this article at: http://www.sciencemag.org/content/306/5702/1727.full.html Supporting Online Material can be found at: http://www.sciencemag.org/content/suppl/2004/11/30/306.5702.1727.DC1.html A list of selected additional articles on the Science Web sites related to this article can be on October 27, 2011 found at: http://www.sciencemag.org/content/306/5702/1727.full.html#related This article has been cited by 70 article(s) on the ISI Web of Science This article has been cited by 10 articles hosted by HighWire Press; see: http://www.sciencemag.org/content/306/5702/1727.full.html#related-urls This article appears in the following subject collections: Planetary Science www.sciencemag.org http://www.sciencemag.org/cgi/collection/planet_sci Downloaded from Science (print ISSN 0036-8075; online ISSN 1095-9203) is published weekly, except the last week in December, by the American Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005. -
18Th EANA Conference European Astrobiology Network Association
18th EANA Conference European Astrobiology Network Association Abstract book 24-28 September 2018 Freie Universität Berlin, Germany Sponsors: Detectability of biosignatures in martian sedimentary systems A. H. Stevens1, A. McDonald2, and C. S. Cockell1 (1) UK Centre for Astrobiology, University of Edinburgh, UK ([email protected]) (2) Bioimaging Facility, School of Engineering, University of Edinburgh, UK Presentation: Tuesday 12:45-13:00 Session: Traces of life, biosignatures, life detection Abstract: Some of the most promising potential sampling sites for astrobiology are the numerous sedimentary areas on Mars such as those explored by MSL. As sedimentary systems have a high relative likelihood to have been habitable in the past and are known on Earth to preserve biosignatures well, the remains of martian sedimentary systems are an attractive target for exploration, for example by sample return caching rovers [1]. To learn how best to look for evidence of life in these environments, we must carefully understand their context. While recent measurements have raised the upper limit for organic carbon measured in martian sediments [2], our exploration to date shows no evidence for a terrestrial-like biosphere on Mars. We used an analogue of a martian mudstone (Y-Mars[3]) to investigate how best to look for biosignatures in martian sedimentary environments. The mudstone was inoculated with a relevant microbial community and cultured over several months under martian conditions to select for the most Mars-relevant microbes. We sequenced the microbial community over a number of transfers to try and understand what types microbes might be expected to exist in these environments and assess whether they might leave behind any specific biosignatures. -
Arctic Grayling and Burbot Studies at the Fort Knox Mine, 2005 by Alvin G
Technical Report No. 05-06 Arctic Grayling and Burbot Studies at the Fort Knox Mine, 2005 by Alvin G. Ott and William A. Morris Pond D in Wetland Complex Photograph by William A. Morris 2005 December 2005 Alaska Department of Natural Resources Office of Habitat Management and Permitting The Alaska Department of Natural Resources administers all programs and activities free from discrimination based on race, color, national origin, age, sex, religion, marital status, pregnancy, parenthood, or disability. The department administers all programs and activities in compliance with Title VI of the Civil Rights Act of 1964, Section 504 of the Rehabilitation Act of 1973, Title II of the Americans with Disabilities Act of 1990, the Age Discrimination Act of 1975, and Title IX of the Education Amendments of 1972. If you believe you have been discriminated against in any program, activity, or facility, or if you desire further information please write to DNR, 1300 College Road, Fairbanks, Alaska 99701; U.S. Fish and Wildlife Service, 4040 N. Fairfax Drive, Suite 300 Webb, Arlington, VA 22203; or O.E.O., U.S. Department of the Interior, Washington DC 20240. For information on alternative formats for this and other department publications, please contact the department ADA Coordinator at (voice) 907-269-8549 or (TDD) 907-269-8411. ARCTIC GRAYLING AND BURBOT STUDIES AT THE FORT KNOX MINE, 2005 By Alvin G. Ott and William A. Morris Kerry M. Howard Executive Director Office of Habitat Management and Permitting Alaska Department of Fish and Game Table of Contents Table of Contents.................................................................................................................I List of Tables .....................................................................................................................iii List of Figures................................................................................................................... -
2017 Chicxulub Revealed
THE UNIVERSITY TEXAS OF AUSTIN AT JACKSON• SCHOOL GEOSCIENCES OF 2017 NEWSLETTER• Newsletter2 017 Chicxulub Revealed A first look at rocks from the crater left by the asteroid that wiped out non-avian dinosaurs WELCOME Dear Alumni and Friends he devastation that Hurricane Harvey brought to Texas communities in August was a tragic reminder of how vital it is to understand our planet and T its processes. Shortly after the hurricane struck, our scientists, through our Rapid Response program, began to conduct research to understand how Harvey has impacted the coast and offshore Gulf of Mexico. This research will help determine the best ways to deal with many coastal issues in the aftermath of the storm, and how we might better prepare for such events in the future. You can read more about the mission on page 18. Rapid response efforts on the effects of abrupt, catastrophic geoscience events COVER: GRANITE FROM THE PEAK RING OF provide critical science that can benefit society. This is what we strive to do here at the THE CHICXULUB CRATER FORMED BY THE Jackson School of Geosciences. This year’s Newsletter holds some tremendous examples. ASTEROID STRIKE THAT WIPED OUT ALL NON- AVIAN DINOSAURS I’d like to draw your attention to the story on page 58 about the scientific coring mission led by Peter Flemings to bring back samples of methane hydrate from ABOVE: MEMBERS OF THE JACKSON beneath the Gulf of Mexico. This is a cutting-edge research project on a potential SCHOOL-LED TEAM CORING FOR SAMPLES OF METHANE HYDRATE IN THE GULF OF MEXICO future energy source that very few schools in the world would be able to mount. -
Phoenix Descending NASA’S Mars Strategy Goes from “Follow the Water” to “Arrive at the Ice”
NEWS NATURE|Vol 453|8 May 2008 Phoenix descending NASA’s Mars strategy goes from “follow the water” to “arrive at the ice”. Since 2001, the slogan for from hardware and software. NASA’s Mars programme has “We may not succeed, but we NASA been “follow the water”. deserve to succeed,” he says. With Phoenix, a US$420- Engineers at the Jet Propul- million mission to the edge of sion Laboratory in Pasadena, the planet’s north ice cap, the California, which runs most of agency hopes to finally touch NASA’s planetary missions, will its quarry, in the form of dirty have their last chance to tweak water ice scraped from the the trajectory on 24 May. The subsurface and melted in the next day, Phoenix is expected probe’s on-board ovens. to use the planet’s atmosphere, If all goes as planned, Phoenix and its own heat shielding, will reach the end of its 680- parachutes and retrorockets, to million-kilometre, 10-month- slow itself down from an orbital long journey on 25 May. Its speed of 20,000 kilometres per landing site is in a region where hour to a soft, safe landing at NASA’s orbiting Mars Odyssey just 2.4 metres per second. spacecraft has detected gamma-ray and neu- Phoenix, a 350-kilogram lander, inherited Smith and his team hope that the ice and soil tron signatures suggesting a significant amount hardware from the Mars Surveyor Lander, a samples they will study with the spacecraft’s of hydrogen — thought to be a constituent of mission cancelled in 2000 after the failure of mass-spectrometer and chemical analysis sys- frozen water — near the surface. -
Summary of Sexual Abuse Claims in Chapter 11 Cases of Boy Scouts of America
Summary of Sexual Abuse Claims in Chapter 11 Cases of Boy Scouts of America There are approximately 101,135sexual abuse claims filed. Of those claims, the Tort Claimants’ Committee estimates that there are approximately 83,807 unique claims if the amended and superseded and multiple claims filed on account of the same survivor are removed. The summary of sexual abuse claims below uses the set of 83,807 of claim for purposes of claims summary below.1 The Tort Claimants’ Committee has broken down the sexual abuse claims in various categories for the purpose of disclosing where and when the sexual abuse claims arose and the identity of certain of the parties that are implicated in the alleged sexual abuse. Attached hereto as Exhibit 1 is a chart that shows the sexual abuse claims broken down by the year in which they first arose. Please note that there approximately 10,500 claims did not provide a date for when the sexual abuse occurred. As a result, those claims have not been assigned a year in which the abuse first arose. Attached hereto as Exhibit 2 is a chart that shows the claims broken down by the state or jurisdiction in which they arose. Please note there are approximately 7,186 claims that did not provide a location of abuse. Those claims are reflected by YY or ZZ in the codes used to identify the applicable state or jurisdiction. Those claims have not been assigned a state or other jurisdiction. Attached hereto as Exhibit 3 is a chart that shows the claims broken down by the Local Council implicated in the sexual abuse. -
March 2009 Newsletter
www.spnhc.org President Richard Rabeler President-Elect Jean-Marc Gagnon Past President Tim White Treasurer Barbara Brown Society for the Preservation March 2009 Secretary Volume 23, Number 1 Judith Price of Natural History Collections Managing Editor Jean F. DeMouthe Editor Scientific Collections: Mission-Critical Andrew C. Bentley Infrastructure for Federal Service Agencies Executive Summary from the report of the Interagency Working Group on Scientific Collections (IWGSC) Beginning in 2005, the White House Office of and human resources. Scientific collections, Science and Technology Policy (OSTP) and as discussed in this report, consist of physi- Office of Management and Budget (OMB) cal objects that are preserved, cataloged, and called on Federal agencies to focus attention managed by Federal agencies and other or- on integrated support and planning for their ganizations for research and other purposes. care and use of Federally held scientific col- Scientific collections do not include art or his- lections. Based in part on these recommen- torical objects, collectibles, or the books and dations, an Interagency Working Group on documents that are stored in libraries and ar- INSIDE... Scientific Collections (IWGSC) was created, chives. The specimens in scientific collections co-chaired by representatives of the were acquired as objects for scientific study, Scientific Collections .. 1 Smithsonian Institution (SI) and the U.S. not for their aesthetic or market value as col- Presidential Report ..... 3 Department of Agriculture (USDA) to exam- lectibles. In general, the contents of these sci- Committee Reports..... 4 ine the current state of Federal scientific col- entific collections are documented and publi- Sessional Committee lections and to make recommendations for cized with the goal of making the specimens reports ....................