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REVIEW Signal Transduction, Cell Cycle Regulatory, and Anti
Leukemia (1999) 13, 1109–1166 1999 Stockton Press All rights reserved 0887-6924/99 $12.00 http://www.stockton-press.co.uk/leu REVIEW Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs WL Blalock1, C Weinstein-Oppenheimer1,2, F Chang1, PE Hoyle1, X-Y Wang3, PA Algate4, RA Franklin1,5, SM Oberhaus1,5, LS Steelman1 and JA McCubrey1,5 1Department of Microbiology and Immunology, 5Leo Jenkins Cancer Center, East Carolina University School of Medicine Greenville, NC, USA; 2Escuela de Quı´mica y Farmacia, Facultad de Medicina, Universidad de Valparaiso, Valparaiso, Chile; 3Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, Rochester, MN, USA; and 4Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA Over the past decade, there has been an exponential increase growth factor), Flt-L (the ligand for the flt2/3 receptor), erythro- in our knowledge of how cytokines regulate signal transduc- poietin (EPO), and others affect the growth and differentiation tion, cell cycle progression, differentiation and apoptosis. Research has focused on different biochemical and genetic of these early hematopoietic precursor cells into cells of the 1–4 aspects of these processes. Initially, cytokines were identified myeloid, lymphoid and erythroid lineages (Table 1). This by clonogenic assays and purified by biochemical techniques. review will concentrate on IL-3 since much of the knowledge This soon led to the molecular cloning of the genes encoding of how cytokines affect cell growth, signal transduction, and the cytokines and their cognate receptors. -
DEKLIM a German Contribution to the IGBP-PAGES Program
PAGES International Project Offi ce Sulgeneckstrasse 38 3007 Bern Switzerland Tel: +41 31 312 31 33 Fax: +41 31 312 31 68 [email protected] Text Editing: Leah Christen News Layout: Christoph Kull Frank Sirocko and Gerrit Lohmann, Guest Editors Circulation: 3400 Christoph Kull and Leah Christen, Editors VOL.12, N°2 – SEPTEMBER 2004 DEKLIM A German Contribution to the IGBP-PAGES Program www.pages-igbp.org Grouping of the 33 DEKLIM-Paleo projects into 13 bundles: This special issue presents results as well as working reports of the ongoing program. A DEKLIM overview is presented in the “Program News” section. Contents 2 Announcements - Climate Change around 117 ka BP - Editorial: DEKLIM Paleo - Climate Transitions: Forcings - Feedbacks - Inside PAGES - Tree Rings, Isotopes and Climate - New on the PAGES Bookshelf - Modeling the Last Glacial Cycle - Global Holocene Climate Variability 4 Program News - Late Glacial Changes in Central Europe - PROPER: Proxies in Paleoclimatology - The Global Carbon Cycle around 20 ka BP - Paleocat: A Catalan Paleo-Network - North Atlantic Coral Climate History - DEKLIM: German Climate Research 33 Workshop Reports 8 National Page - Holocene Climate in the Alps - France - Ethiopia - Holocene Monsoon Variability - India - African Paleoenvironments - Kenya 9 Science Highlights - Climate Change in Southern Patagonia 36 Last Page - Modeling the Atmospheric Circulation - Calendar - Solar Variability and Holocene Climate - The PAGES Product Database - 18O/16O Ratio during Heinrich Event 1 ISSN 1563–0803 The PAGES International Project Offi ce and its publications are supported by the Swiss and US National Science Foundations and NOAA. 2 Announcements Announcements 3 Editorial: DEKLIM - PALEO The results of climate research enjoy a high level of public interest. -
The West Wing Weekly Episode 1:05: “The Crackpots and These Women
The West Wing Weekly Episode 1:05: “The Crackpots and These Women” Guest: Eli Attie [West Wing Episode 1.05 excerpt] TOBY: It’s “throw open our office doors to people who want to discuss things that we could care less about” day. [end excerpt] [Intro Music] JOSH: Hi, you’re listening to The West Wing Weekly. My name is Joshua Malina. HRISHI: And I’m Hrishikesh Hirway. JOSH: We are here to discuss season one, episode five, “The Crackpots and These Women”. It originally aired on October 20th, 1999. This episode was written by Aaron Sorkin; it was directed by Anthony Drazan, who among other things directed the 1998 film version of David Rabe’s Hurlyburly, the play on which it was based having been mentioned in episode one of our podcast. We’re coming full circle. HRISHI: Our guest today is writer and producer Eli Attie. Eli joined the staff of The West Wing in its third season, but before his gig in fictional D.C. he worked as a political operative in the real White House, serving as a special assistant to President Bill Clinton, and then as Vice President Al Gore’s chief speechwriter. He’s also written for Studio 60 on the Sunset Strip, House, and Rosewood. Eli, welcome to The West Wing Weekly. ELI: It’s a great pleasure to be here. JOSH: I’m a little bit under the weather, but Lady Podcast is a cruel mistress, and she waits for no man’s cold, so if I sound congested, it’s because I’m congested. -
ICD-9 Diagnosis Codes Effective 10/1/2011 (V29.0) Source: Centers for Medicare and Medicaid Services
ICD-9 Diagnosis Codes effective 10/1/2011 (v29.0) Source: Centers for Medicare and Medicaid Services 0010 Cholera d/t vib cholerae 00801 Int inf e coli entrpath 01086 Prim prg TB NEC-oth test 0011 Cholera d/t vib el tor 00802 Int inf e coli entrtoxgn 01090 Primary TB NOS-unspec 0019 Cholera NOS 00803 Int inf e coli entrnvsv 01091 Primary TB NOS-no exam 0020 Typhoid fever 00804 Int inf e coli entrhmrg 01092 Primary TB NOS-exam unkn 0021 Paratyphoid fever a 00809 Int inf e coli spcf NEC 01093 Primary TB NOS-micro dx 0022 Paratyphoid fever b 0081 Arizona enteritis 01094 Primary TB NOS-cult dx 0023 Paratyphoid fever c 0082 Aerobacter enteritis 01095 Primary TB NOS-histo dx 0029 Paratyphoid fever NOS 0083 Proteus enteritis 01096 Primary TB NOS-oth test 0030 Salmonella enteritis 00841 Staphylococc enteritis 01100 TB lung infiltr-unspec 0031 Salmonella septicemia 00842 Pseudomonas enteritis 01101 TB lung infiltr-no exam 00320 Local salmonella inf NOS 00843 Int infec campylobacter 01102 TB lung infiltr-exm unkn 00321 Salmonella meningitis 00844 Int inf yrsnia entrcltca 01103 TB lung infiltr-micro dx 00322 Salmonella pneumonia 00845 Int inf clstrdium dfcile 01104 TB lung infiltr-cult dx 00323 Salmonella arthritis 00846 Intes infec oth anerobes 01105 TB lung infiltr-histo dx 00324 Salmonella osteomyelitis 00847 Int inf oth grm neg bctr 01106 TB lung infiltr-oth test 00329 Local salmonella inf NEC 00849 Bacterial enteritis NEC 01110 TB lung nodular-unspec 0038 Salmonella infection NEC 0085 Bacterial enteritis NOS 01111 TB lung nodular-no exam 0039 -
Office Olympics Fundraising Ideas
Office Olympics Fundraising in the office can be a tricky task but holding an Office Olympics can combat that. Whether you need to engage your team, motivate the masses, or identify a fun team building opportunity that can also raise funds for Together for Short Lives, Office Olympics has it all! Hosting an Office Olympics You could dedicate an annual is one thing but coming up week to go full steam ahead with ideas for the various with the celebrations or you challenges is another. could incorporate them into Fortunately, Together for your weekly office routine, Short Lives are on hand to holding one event at the end help you with inspiration. See of each week. Donations below for the latest Olympic could be taken upon entry sports that will certainly get into a sport, or through the crowds behind you. sponsorship on an office just giving page. Javelin Desk Designs Olympic Quiz Get your pencils at the ready! Set In the lead-up to the Olympics, ask Test your Olympic based knowledge up a Javelin event and see who each team to pick the name of a in an office quiz. Range questions can throw their pencil the furthest. country out of a hat. Then get the across all disciplines and see who Why not make your own javelins, teams to decorate their desk to comes out on top. set the task at the beginning of the reflect their chosen country. Best week and watch as they evolve into desk wins a prize. masterpieces set to win? Desk Chair Race Bin Basketball Rubber Band Archery Challenge an opponent and race Span across the office with your Utilise your office resources and down a corridor, around the office basketball court. -
2017 Chicxulub Revealed
THE UNIVERSITY TEXAS OF AUSTIN AT JACKSON• SCHOOL GEOSCIENCES OF 2017 NEWSLETTER• Newsletter2 017 Chicxulub Revealed A first look at rocks from the crater left by the asteroid that wiped out non-avian dinosaurs WELCOME Dear Alumni and Friends he devastation that Hurricane Harvey brought to Texas communities in August was a tragic reminder of how vital it is to understand our planet and T its processes. Shortly after the hurricane struck, our scientists, through our Rapid Response program, began to conduct research to understand how Harvey has impacted the coast and offshore Gulf of Mexico. This research will help determine the best ways to deal with many coastal issues in the aftermath of the storm, and how we might better prepare for such events in the future. You can read more about the mission on page 18. Rapid response efforts on the effects of abrupt, catastrophic geoscience events COVER: GRANITE FROM THE PEAK RING OF provide critical science that can benefit society. This is what we strive to do here at the THE CHICXULUB CRATER FORMED BY THE Jackson School of Geosciences. This year’s Newsletter holds some tremendous examples. ASTEROID STRIKE THAT WIPED OUT ALL NON- AVIAN DINOSAURS I’d like to draw your attention to the story on page 58 about the scientific coring mission led by Peter Flemings to bring back samples of methane hydrate from ABOVE: MEMBERS OF THE JACKSON beneath the Gulf of Mexico. This is a cutting-edge research project on a potential SCHOOL-LED TEAM CORING FOR SAMPLES OF METHANE HYDRATE IN THE GULF OF MEXICO future energy source that very few schools in the world would be able to mount. -
Summary of Sexual Abuse Claims in Chapter 11 Cases of Boy Scouts of America
Summary of Sexual Abuse Claims in Chapter 11 Cases of Boy Scouts of America There are approximately 101,135sexual abuse claims filed. Of those claims, the Tort Claimants’ Committee estimates that there are approximately 83,807 unique claims if the amended and superseded and multiple claims filed on account of the same survivor are removed. The summary of sexual abuse claims below uses the set of 83,807 of claim for purposes of claims summary below.1 The Tort Claimants’ Committee has broken down the sexual abuse claims in various categories for the purpose of disclosing where and when the sexual abuse claims arose and the identity of certain of the parties that are implicated in the alleged sexual abuse. Attached hereto as Exhibit 1 is a chart that shows the sexual abuse claims broken down by the year in which they first arose. Please note that there approximately 10,500 claims did not provide a date for when the sexual abuse occurred. As a result, those claims have not been assigned a year in which the abuse first arose. Attached hereto as Exhibit 2 is a chart that shows the claims broken down by the state or jurisdiction in which they arose. Please note there are approximately 7,186 claims that did not provide a location of abuse. Those claims are reflected by YY or ZZ in the codes used to identify the applicable state or jurisdiction. Those claims have not been assigned a state or other jurisdiction. Attached hereto as Exhibit 3 is a chart that shows the claims broken down by the Local Council implicated in the sexual abuse. -
March 2009 Newsletter
www.spnhc.org President Richard Rabeler President-Elect Jean-Marc Gagnon Past President Tim White Treasurer Barbara Brown Society for the Preservation March 2009 Secretary Volume 23, Number 1 Judith Price of Natural History Collections Managing Editor Jean F. DeMouthe Editor Scientific Collections: Mission-Critical Andrew C. Bentley Infrastructure for Federal Service Agencies Executive Summary from the report of the Interagency Working Group on Scientific Collections (IWGSC) Beginning in 2005, the White House Office of and human resources. Scientific collections, Science and Technology Policy (OSTP) and as discussed in this report, consist of physi- Office of Management and Budget (OMB) cal objects that are preserved, cataloged, and called on Federal agencies to focus attention managed by Federal agencies and other or- on integrated support and planning for their ganizations for research and other purposes. care and use of Federally held scientific col- Scientific collections do not include art or his- lections. Based in part on these recommen- torical objects, collectibles, or the books and dations, an Interagency Working Group on documents that are stored in libraries and ar- INSIDE... Scientific Collections (IWGSC) was created, chives. The specimens in scientific collections co-chaired by representatives of the were acquired as objects for scientific study, Scientific Collections .. 1 Smithsonian Institution (SI) and the U.S. not for their aesthetic or market value as col- Presidential Report ..... 3 Department of Agriculture (USDA) to exam- lectibles. In general, the contents of these sci- Committee Reports..... 4 ine the current state of Federal scientific col- entific collections are documented and publi- Sessional Committee lections and to make recommendations for cized with the goal of making the specimens reports .................... -
Midnight Madness Celebrates the Start of Basketball Season
ASCUI Corner Local Everything Eagles Showcase INSIDE THE ASCUI Survey Breast Cancer Awareness Caf Cashier Earns Netflix’s Options For a Perfect Inspires New Month: How Susan G. Komen Regional Recognition “Fright Night” Seating on Campus Is Making a Difference pg. 7 pg. 8 NEWS pg. 2 pg. 5 THE CONCORDIA INVESTIGATE.INFORM.IGNITE.INVOLVE. Volume 12, Issue 4 Concordia University Irvine Friday, October 20, 2017 Tonight! Midnight Madness Celebrates Caf Cashier the Start of Basketball Season Earns Regional Recognition ANNIE STUDDERT STAFF WRITER Bon Appetít employee, Aracely Alfaro, earned regional recognition for her outstanding cus- tomer service and com- mitment to excellence as Concordia’s weekday cafeteria cashier Alfaro won the award for the “Superhero of Excellent Customer Service” of the Pacific Northwest, California, and parts of Utah. It is part of the campaign by CUI cheer team at 2016 Midnight Madness PC: cuieagles.com Compass Group North Red Bull, giveaways and performing in front of CU Arena until midnight. America. Each year, ANDERSON CLARKE more! At 10:30 p.m. the friends and family for the Amy Haney, Cheer Compass Group NA STAFF WRITER party will move inside first time this year.” and Stunt Coach and holds its annual “Night Midnight Madness, one the CU Arena where our Alvis-Labadie said Screaming Eagles of the Stars” Gala to of Concordia’s largest school mascot, Marty the students should come coordinator said that honor its top employees. student events of the Eagle, will make a grand to watch their cheer Midnight Madness is This year’s theme was year, is tonight. -
Et Mail Front Mexico Hints a T Icmocket Total
■ v'., : • ':■■ I* ^AOE rOURTEEN TUESDAY* KOVEBfBER 17,1989 Average Dally Net Ptcm Ron ifiatirlrf^pr lEofnhtg F ar Om Weak IM ae Tilt Weather N*4r. M. lese ! «r V. A waeaam . Center' Church Motheri'- Club plana calling for :only bna upatatra of 232 Spring SL which 'would be than regulations allow. The prop AboiilTciwii tl-iu mpet In the Federation room ^ B A D enies apartmant inauad of the formarly Closer to the street line than reg erty Li located east of 1768 Tol-. 13,041 'I tomoh-ow at 8 p'.m. Miaa M argaret propoaed two-in the building, were ulation* allow. Former Police land 'Tpke. T f l L f . Laar lAW . Parker M Children'* Service* udll submitted last-night. Atty. John D. Chief Herman ; O, Schendel and Tabled'sfas ,* request lor ah ex M anbar ^ WfiT AM H ' XI Ounm» dhapter of Beta SiR- hfe guest speaker. Refreshments Ware Bid to LsBelle repraschted the appllcsnt.. Atty^ Donald Richter qtoke In op tension of permiasidn eought by meftiu B m m irw f Otrewhrtiaa. Kc Wil will meet !> o’clock to- will be 'servrt, ^ In other action, tha toners ap position. Atty. LaBelle represent Samuel Lombkrdo to maintain a ManchmttBr"^A City of ViUoge Charm iam- mgk iHMMe to wnwr Ms. n llk t a t tka Tiome ot^Mra. Jamer '* , * ■ i proved a variance -request from ed the applicant. building, for storage and shelter FUchmend. ^4T Btimmlt St. , St. Anne's Mothers' Circle’ wilt Pack Chutes Dr. Robert. C. Walden Jr., 102 The board dented a request froth for a watchman on the east side : Find It At. -
Cong Sounds Peace Overture
■ < V'; The Weather Kaak First-Day Open Leader Fair tonight. Low 50 to 55, chance - of rain 10 per cent. Goudy Page 16 lEuf mnn I Tuesday with a 30 per cent V chance of showers; hl^ in the .low 80s. MANCHESTER — 4 City o f Village Charm TWENTY-TWO PAGES MANCHESTER, CONN., MONDAY, SEPTEMBER 11,19^2 VOL. XCI. No. 291 PRICE FIFTEEN CENTS Students Take Cong Sounds ^Strike’ Recess tj Over Nation Peace Overture previous formula for the makeup By THE ASSOaATED PRESS SAIGON (AP) - The Viet Once again it called on the of the government of national Cong issued a new peace United States to withdraw all its Negotiations remained deadlocked today in the concord—a three-segment coali statement today saying it is troops from Vietnam, to stop Philadelphia teachers strike, but Kansas City youngsters supporting the regime of Presi tion composed of (1) members of "prepared to accept a were back in class and there were signs of progress in several dent Nguyen Van Thieu, and to the Provisional Revolutionary other school walkouts across the country. - ^ provisional government of halt the bombing and mining of Government, (2) members of the national concord that shall be Saigon administration excluding Spokesmen for both the P'riday because custodians and North Vietnam. dominated by neither side." Thieu, and (3) representatives of teachers' union and the maintenance workers were on U.S, sources In Saigon inter " Should the U.S. government other political forces in South Philadelphia School Board ex strike and trash had accumulated preted this as a concession that really respect the South Viet Vietnam ""including those who, pressed doubt Sunday that the at the schools. -
Exemplar Texts for Grades
COMMON CORE STATE STANDARDS FOR English Language Arts & Literacy in History/Social Studies, Science, and Technical Subjects _____ Appendix B: Text Exemplars and Sample Performance Tasks OREGON COMMON CORE STATE STANDARDS FOR English Language Arts & Literacy in History/Social Studies, Science, and Technical Subjects Exemplars of Reading Text Complexity, Quality, and Range & Sample Performance Tasks Related to Core Standards Selecting Text Exemplars The following text samples primarily serve to exemplify the level of complexity and quality that the Standards require all students in a given grade band to engage with. Additionally, they are suggestive of the breadth of texts that students should encounter in the text types required by the Standards. The choices should serve as useful guideposts in helping educators select texts of similar complexity, quality, and range for their own classrooms. They expressly do not represent a partial or complete reading list. The process of text selection was guided by the following criteria: Complexity. Appendix A describes in detail a three-part model of measuring text complexity based on qualitative and quantitative indices of inherent text difficulty balanced with educators’ professional judgment in matching readers and texts in light of particular tasks. In selecting texts to serve as exemplars, the work group began by soliciting contributions from teachers, educational leaders, and researchers who have experience working with students in the grades for which the texts have been selected. These contributors were asked to recommend texts that they or their colleagues have used successfully with students in a given grade band. The work group made final selections based in part on whether qualitative and quantitative measures indicated that the recommended texts were of sufficient complexity for the grade band.