314 Antibacterials
2. Miceli JN, et al. Isoniazid (INH) kinetics in children. Fedn Proc 1983; 42: gapore: Merip; Rimactazid; Spain: Amiopiat; Duplicalcio B l2t; p. 294.2). The general absence of an interaction between ll40. Rifater; Rifinah; Rimactazidt; Rimcuret; Rimstar; Tisobrift; josamycin and theophylline would appear to support this. 3. Mouries D, et a!. Passage articulaire de l'isoniazide et de !'ethambutol: Swed.: Rimactazid; Rimcure; Rimstar; Switz.: Rifater; Rifinah; deux observations de synovite tuberculeuse du genou. Nouv Presse Med Rimactazid; Rimstar; Thai.: Rifafour; Rifampyzid; Rifater; 1975; 4: 2734. Antimicrobial Action 4. Gurumurthy P, et al. Salivary levels of isoniazid and rifampicin in Rifinah; Rimactazidf; Rimcure 3� FDC; Rimstart; UK: Rifater; tuberculous patients. Tubercle 1990; 71: 29-33. Rifinah; Rimstar; Voractiv; USA: IsonaRif; Rifamate; Rifater; As for Erythromycin, p. 295.1. Some reports suggest that Venez. : Rimactazid; Rimcure. josamycin may be more active against some strains of HIV-infected patients. Malabsorption of isoniazid and Pharmacopoeial Preparations anaerobic species such as Bacteroides fragilis. other antituberculous drugs may occur in patients with BP 2014: Isoniazid Injection; Isoniazid Oral Solution; Isoniazid HIV infection and tuberculosis, and may contribute to Tablets; acquired drug resistance and reduced efficacy of tuber USP 36: Isoniazid Injection; Isoniazid Syrup; Isoniazid Tablets; culosis treatment. For further information on the absorp Rifampin and Isoniazid Capsules; Rifampin, Isoniazid, and Proprietary Prepara�ons (details are given in Volume B) tion of antituberculous drugs in HIV-infected patients see Pyrazinamide Tablets; Rifampin, Isoniazid, Pyrazinamide, and Single-ingredient Preparations. Austria: Josalid; China: Bei Pharmacokinetics, under Rifampicin, p. 356.1. Ethambutol Hydrochloride Tablets. beisha Josamy Fr.: Josacine; Ital. : Iosalide; Jpn: Josamy;(!i!!i!IJ:); Rus.: Wilprafen(!ifffJ;); (BII.lThrrpa¢eH); Spain: Josamina; Pregnancy. Isoniazid crosses the placenta and average Ukr. : Wilprafen (BmThnpa P.r.�P.�.r�_ti()_n. �...... ProprietaryPreparations (details are given in Volume B) Single�ingredient Preparations. Arg.: Isoniac; Nicotibina; Belg.: Nicotibine; Canad.: Isotamine B; Isotamine; China: Jieheqing (t/ff!'ii;lf); Pi Jin (il1iit); Sheng Jun Cz. : Nidrazid; Fin.: Tubilysin; Fr.: Rimifon; Ger.: Isozid camp(itt:El); N; Isozid; tebesium�s; tebesium; Gr.: Cemidon; Dianicotyl; Nicozidt; Hong Kong: Tri� sofortt; Hung. : Isonicid; India: Iso-Rifa; Isokin; Isonex; Rifa� com-EZ; Indon.: INH�Ciba; INHA; Inoxin; Kapedoxin; Medinh� ODt; Niacifort-6; Nufadoxin; Pehadoxin; Pulmolint; Pyravit; Ph. Eur. 8: (Kanamycin Acid Sulfate). A form of kanamycin Pyrifortt; Suprazid; TB Vit 6; Ital.: Nicozid; Jpn: Hydra; Hydra Ph. Eur. 8; (Josamycin). A macrolide antibiotic produced by sulfate prepared by adding sulfuric acid to a solution of zidet; Mex.: Hidrasix; Isodo Tbal; Valifol; Philipp. : Comprilex; certain strains of Streptomyces narbonensis var. josamyceticus kanamycin sulfate and drying by a suitable method. A white A Curazid (Reformulated); Eurocoxin; Isodexid; Isonid; Isoprim; var. nova, or obtained by any other means. white or or almost white, hygroscopic powder containing not less Isoxin; Nicetalt; Odinah; Pulmodrin; Techxafort; Terozid; Triso slightly yellowish, slightly hygroscopic powder. It contains a than 670 units/mg and 23 to 26% of sulfate, calculated with fortt; Vamsoxidt; Zidrid; Pol. : Nidrazid; Port.: Hidrazida; Rus.: minimum of 900 units/mg calculated with reference to the reference to the dried material. Soluble I in about I of Isozid (llio3H,ll;); Isozid Camp (l13o3H,ll; Kmm); Singapore: dried substance. Very slightly soluble in water; soluble in water; practically insoluble in alcohol and in acetone. A l% Rimifon; Spain: Cemidon B6; Cemidon; Swed.: Tibinide; acetone; freely soluble in dichloromethane and in methyl solution in water has a pHof 5.5 to 7.5. Switz. : Rimifon; Thai.: Antimic; Myrin�Pt; Turk.: INH; Isovit; alcohol. Store in airtight containers. USA: Laniazid; Nydrazid. Kanamycin Sulfate (BANM, rtNNM! Multi-ingredient Preparations. Arg.: Bacifimt; Rifinah; Austria: Josamycin Propionate IBANM, rtNNM} Isoprodiant; Rifater; Rifoldin mit INH; Braz. : Isoniatont; �anamidf}a,,sutfati,l Kan am.lein- n. Canad.: Rifater; China: An Si Nuo Kang ('!<'Wi�fflft); Chang J(l�am!d�a, .·. .f6 samitit1 ptopionat��; nade; n-ip .. · · . •.. ... �ropl6n�tt0' cfe: , c) �<.a n cin Sulphate� . . . · . •;(npnl.v Wei Rui Da Xin (i\:Ji14Jjffli;5:JV;:); Dai Fei Lin (Iii<�#); Fei An J:>ropio at() de; a ni Jqsamy _ .· · . . · � e:i Propion�s; menosu!fatas; wn ycin.A �1onosufpha\tt;. K,lnamyfin '!<');Fei Lu De Fei Ning ('/h'T");Fei Su (�;)):); Fei Ting Jbsamyc.iopropion;::ine; Jq rtlycln·prop.Josionat;tnyl<::>samysiinip pid[laatti; sulfflt . monon((! f.Kana:my<:tnJJr!osuff�s .EJ:>Ko>iJMIAUV! All cross-references refer to entries in Volume A