314 Antibacterials 2. Miceli JN, et al. Isoniazid (INH) kinetics in children. Fedn Proc 1983; 42: gapore: Merip; Rimactazid; Spain: Amiopiat; Duplicalcio B l2t; p. 294.2). The general absence of an interaction between ll40. Rifater; Rifinah; Rimactazidt; Rimcuret; Rimstar; Tisobrift; josamycin and theophylline would appear to support this. 3. Mouries D, et a!. Passage articulaire de l'isoniazide et de !'ethambutol: Swed.: Rimactazid; Rimcure; Rimstar; Switz.: Rifater; Rifinah; deux observations de synovite tuberculeuse du genou. Nouv Presse Med Rimactazid; Rimstar; Thai.: Rifafour; Rifampyzid; Rifater; 1975; 4: 2734. Antimicrobial Action 4. Gurumurthy P, et al. Salivary levels of isoniazid and rifampicin in Rifinah; Rimactazidf; Rimcure 3� FDC; Rimstart; UK: Rifater; tuberculous patients. Tubercle 1990; 71: 29-33. Rifinah; Rimstar; Voractiv; USA: IsonaRif; Rifamate; Rifater; As for Erythromycin, p. 295.1. Some reports suggest that Venez. : Rimactazid; Rimcure. josamycin may be more active against some strains of HIV-infected patients. Malabsorption of isoniazid and Pharmacopoeial Preparations anaerobic species such as Bacteroides fragilis. other antituberculous drugs may occur in patients with BP 2014: Isoniazid Injection; Isoniazid Oral Solution; Isoniazid HIV infection and tuberculosis, and may contribute to Tablets; acquired drug resistance and reduced efficacy of tuber­ USP 36: Isoniazid Injection; Isoniazid Syrup; Isoniazid Tablets; culosis treatment. For further information on the absorp­ Rifampin and Isoniazid Capsules; Rifampin, Isoniazid, and Proprietary Prepara�ons (details are given in Volume B) tion of antituberculous drugs in HIV-infected patients see Pyrazinamide Tablets; Rifampin, Isoniazid, Pyrazinamide, and Single-ingredient Preparations. Austria: Josalid; China: Bei­ Pharmacokinetics, under Rifampicin, p. 356.1. Ethambutol Hydrochloride Tablets. beisha Josamy Fr.: Josacine; Ital. : Iosalide; Jpn: Josamy;(!i!!i!IJ:); Rus.: Wilprafen(!ifffJ;); (BII.lThrrpa¢eH); Spain: Josamina; Pregnancy. Isoniazid crosses the placenta and average Ukr. : Wilprafen (BmThnpa<jleH) . fetal concentrations of 61.5 and 72.8% of maternal serum Ital.: Corti-Fluoral. or plasma concentration have been reported.1 The half-life Multi-ingredientPreparations. of isoniazid may be prolonged in neonates. I 1. Holdiness MR. Transplacental pharmacokinetics of the antituberculosis drugs. Clin Pharmacokinet 1987; 13: 125-9. P.r.�P.�.r�_ti()_n. �............ ........................................... ProprietaryPreparations (details are given in Volume B) Single�ingredient Preparations. Arg.: Isoniac; Nicotibina; Belg.: Nicotibine; Canad.: Isotamine B; Isotamine; China: Jieheqing (t/ff!'ii;lf); Pi Jin (il1iit); Sheng Jun Cz. : Nidrazid; Fin.: Tubilysin; Fr.: Rimifon; Ger.: Isozid camp(itt:El); N; Isozid; tebesium�s; tebesium; Gr.: Cemidon; Dianicotyl; Nicozidt; Hong Kong: Tri� sofortt; Hung. : Isonicid; India: Iso-Rifa; Isokin; Isonex; Rifa� com-EZ; Indon.: INH�Ciba; INHA; Inoxin; Kapedoxin; Medinh� ODt; Niacifort-6; Nufadoxin; Pehadoxin; Pulmolint; Pyravit; Ph. Eur. 8: (Kanamycin Acid Sulfate). A form of kanamycin Pyrifortt; Suprazid; TB Vit 6; Ital.: Nicozid; Jpn: Hydra; Hydra­ Ph. Eur. 8; (Josamycin). A macrolide antibiotic produced by sulfate prepared by adding sulfuric acid to a solution of zidet; Mex.: Hidrasix; Isodo Tbal; Valifol; Philipp. : Comprilex; certain strains of Streptomyces narbonensis var. josamyceticus kanamycin sulfate and drying by a suitable method. A white A Curazid (Reformulated); Eurocoxin; Isodexid; Isonid; Isoprim; var. nova, or obtained by any other means. white or or almost white, hygroscopic powder containing not less Isoxin; Nicetalt; Odinah; Pulmodrin; Techxafort; Terozid; Triso­ slightly yellowish, slightly hygroscopic powder. It contains a than 670 units/mg and 23 to 26% of sulfate, calculated with fortt; Vamsoxidt; Zidrid; Pol. : Nidrazid; Port.: Hidrazida; Rus.: minimum of 900 units/mg calculated with reference to the reference to the dried material. Soluble I in about I of Isozid (llio3H,ll;); Isozid Camp (l13o3H,ll; Kmm); Singapore: dried substance. Very slightly soluble in water; soluble in water; practically insoluble in alcohol and in acetone. A l% Rimifon; Spain: Cemidon B6; Cemidon; Swed.: Tibinide; acetone; freely soluble in dichloromethane and in methyl solution in water has a pHof 5.5 to 7.5. Switz. : Rimifon; Thai.: Antimic; Myrin�Pt; Turk.: INH; Isovit; alcohol. Store in airtight containers. USA: Laniazid; Nydrazid. Kanamycin Sulfate (BANM, rtNNM! Multi-ingredient Preparations. Arg.: Bacifimt; Rifinah; Austria: Josamycin Propionate IBANM, rtNNM} Isoprodiant; Rifater; Rifoldin mit INH; Braz. : Isoniatont; �anamidf}a,,sutfati,l Kan am.lein- n. Canad.: Rifater; China: An Si Nuo Kang ('!<'Wi�fflft); Chang J(l�am!d�a, .·. .f6 samitit1 ptopionat��; nade; n-ip .. · · . •.. ... �ropl6n�tt0' cfe: , c) �<.a n cin Sulphate� . · . •;(npnl.v Wei Rui Da Xin (i\:Ji14Jjffli;5:JV;:); Dai Fei Lin (Iii<�#); Fei An J:>ropio at() de; a ni Jqsamy­ _ .· · . · � e:i Propion�s; menosu!fatas; wn ycin.A �1onosufpha\tt;. K,lnamyfin '!<');Fei Lu De Fei Ning ('/h'T");Fei Su (�;)):); Fei Ting Jbsamyc.iopropion;::ine; Jq rtlycln·prop.Josionat;tnyl<::>samysiinip pid[laatti; sulfflt . monon((! f<a �� (!II � sa [Q rat·. mones\Jlfure t!Rlmycine, Sulfgte (�')<); Hu Fei (Te iffl:(ir'�!fif);1'!); Ke Lao Er Kang (5'1:9l'!J;3l:); Pi Lv Jozamisin_-pt�Qpio oat; .Proplonatp ,;!e . Jgsarrlid!ia; S.uipha.te; dei . Mni!m)idne;· rneAasu!fa s;.>.Kana:my<:tnJJ<a Rui Fu An Kang (li\\iilil'!<'3l:); Rui Qing (li\\ii;lf);Ti Bi �2QI?; Kanamy�l�i .• f\<l<>r!osuff�s .EJ:>Ko>iJMIAUV!<ia npon\'at�<,�r de; · n ·.·l<ana i (iJ1j;l!);Wei Bao (£fi'Jll;); Wei Fei (£fi'�);Yi Bi Fu (1/<btilil);Yi Nuo(� . .MC)nohyqrtc�s;• · Ka amytlni.• .. sutfa�;. m��rqmo(l;Js�.Sil'at; Josamy<;:in ·. · Ni!i(!); Kang (ltl�Jilfflft);Yi Ti Bi Denm.: Rimactazid; Rim­ 0'i1f0Ph?nate, •. Kanaft1ycyny slaraan; Kanamysilflimoi'<�Yl�atti; Sulfa�(! <:!e ] ·.. '.··••·· ··· cure; Rimstar; Fin.: Rimactazid; Rimstar; Fr.: Rifater; Rifinah; c,,J:!73f'•!Oj•=SIJ1,l .< • . l<anamicina:; Kaa�l'!Ll\1fl<l.(Yilb¢";>T: ····· (il'm!i!l); · · < '· · Ger. : Iso�Eremfat; Rifatert; Rifinaht; tebesium Duo; tebesium ·Gf\5' "'C 56] )J-J$-'4; 40922 cl7.-8.. 6-0:(3-Amino.-3-deoxy.a-o-gtucopyraoosyl1'4< < ({l-amtno-& Trio; Gr. : Myambutol-INH; Oboliz; Rifater; Rifinah; Rimactazid; ATC -f01FA07. -()- • deoxy-a-o-glucppyranosyl)•2-<:leoxystrepti>mine suJphale. Hong Kong: Rifater; Rifinah; Hung.: Rifazid; India: AFB3; AK\Iet__,. QJ(i ii'Aol. • ·· , • '· AFB4; Akt-2; Akt-3; Akt-4; Akt-FD; Akurit-3; Akurit-4; Akurit­ I,JNJf...,._ 053 11/14806 '( , > Z; Akurit; Antibin; Arzade; Arzidet; Becox Forte Kit; Becox C,.mqnbht3t;N<C),hy<:ltilte,,t:h;i()�,H;. .6 RH; Bicox Kid; Bicox�E; Bicox; Binex DT; Binex E; Binex Kid; Pharmacopoeias. In Bur. (see p. vii) and Jpn. ,--, 59�01, 2538�-.94-o (t{nhyi'iiou$ · • · ..· · · · ·.· · . Binex Z; Binex ZE; Binex; Cavidin INH; Cavirip; Cavitar RHE; Ph. Eur. 8: (Josamycin Propionate). It is derived from a (:"AS ·So (f;qn�a.rrJY(io);· ·• . ... ••· •.·.•· .. .. •. •. \ ,, ····• . }. Caviter FD; Caviter; Combunex; Confez�3; Coxina-3; Coxina�4; macrolide antibiotic produced by certain strains of kaoarrycin .st�lfateJ · . ' · · · · ATC;e..- A07MOti;CJ(J IGil04; 501Af,\24• ·•· . ..· ••·· ·• • Coxinex; Coxkit-3; Coxpic; Coxrid; Coxter-2; Coxter-3; Coxter� . ...· ' Streptomyces narbonensis var. josamyceticus var. nova, or --.--, QSQ-lAf,\,24. •..•.. •....•••• .•. .··. ·•.··. · ·• 4; Cx�3; Cx-4; Cx�5; Emrif Kit; Emrif; Eufacin Inh; Eufacin obtained by any other means. A white or slightly yellowish, ATCYet 0A if7AA 08; CJJOI G804; Plus; Eufazid; Famcin H; Faminex Forte; Faminex; Forecox; · � slightly hygroscopic, crystalline powder. It contains a UNII .OW'7Nt!G4R9W. (kanemycin . sulf1;1te); J8 0£X28SMQ Gocox Compound; Gocox�3; Inabutol Fortet; Inapas; Infez-4; minimum of 843 units/mg, calculated with reference to the (kanamycin-A suifr;�tg) , Ipcacin Kidt; Ipcacin; Ipcazide; Iso-Ripharmed; Isokin-300; Iso­ Pharmacopoeias. In Bur. (see p. vii) and US. kin-T Forte; Isokoxi; Isorifam; Lifebutol-H; Macox Plus; Macox­ dried substance. Practically insoluble in water; soluble in Jpn includes the anhydrous substance. ZH; Monto-2; Monto-3; Monto-4; Montonex Forte; Montorip; acetone; freely soluble in dichloromethane and in methyl Mycocox-4; Mycocox-E; Mycocox�Z; Mycocox; Mycodot Kit; alcohol. Store in airtight containers. Ph. Eur. 8: (Kanamycin Monosulfate; Kanamycin Sulfate Mycodot�4; Mycodot-E; Mycodot-Z; Myconex; Mycospas; BP 2014). The sulfate of an antimicrobial substance Mycurit�3; Mycurit�4; Mycurit�Z; Optirifa Plus; R-Cinex Z; R� Uses and Administration produced by the growth of certain strains of Streptomyces Cinex; RHZ Plus; RHZ; Rifa E; Rifa; Rimactazid Z; Rimpazid; kanamyceticus. A white or almost white, crystalline powder + Josamycin is a macrolide antibacterial with actions and uses Siticox-JNHt; Tibirim INH; Tricox; Wokex�2; Wokex�3; Wokex- containing not less than 750units/mg and 15.0 to 17.0% of 4; Xeed 2; Xeed 3E; Xeed 4; Indon.: bacbut!NH; Erabutol Plus; similar to those of erythromycin (p. 292.1). It is given orally sulfate, calculated with reference to the dried material. Meditam�6f; Metham; Mycothambin-INHt; Niazitol; Pulna; as the base or the propionate but doses are expressed in Soluble 1 in about 8 of water; practically insoluble in alcohol terms of the base; 1.07 g of josamycin propionate is Ramicin-ISOf; Rimactazid; Rimcure; Rimstar; Santibi Plus; Irl. : and in acetone. A I%