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Antibiotics Used in Human Medicines in the EU

Antibiotics Used in Human Medicines in the EU

Antibiotic Resistance in the European Union Associated with Therapeutic use of Veterinary Medicines

Report and Qualitative Risk Assessment by the Committee for Veterinary Medicinal Products

Annex I

Antibiotics authorised for Therapy in Food Producing Animals in the EU

(Tables 6 - 10)

ãEMEA 1999 Annex I - used in Veterinary Medicine (January 1999)

TABLE 6 ANTIBIOTICS AUTHORISED FOR FOOD PRODUCING ANIMALS IN THE EU - ORAL USE

Combination of active IT F SP EL PO UK IRE BE NL AU DE DK FIN SW Use in ingredients Humans b-lactam Penicillins B / P / A P P P B / P / A + Ampicillin / Amoxycillin B / P / A B / P / A B / P / A B / P /A B / P / A B / P / A / F B / P / A / F P / A B / P / A B / P B / P / A B / P / F B / P B / P + Amoxycillin+clavulanic acid B B / A P B B B B + Isoxazolyl - Penicillins B / P B + (Met/Oxa/Di/Cloxa/Naf)

Cephalosporins B / P P + / related

Aminoglycosides Dihydro / B / P B / P / A B B / P B / P / A B / P / A B B / P + / related B / P / A B / P / A B / P / A A B / P / A B / P / A B / P / A B / P B / P / A B / P / A B / P / A B / P / A related Kanamycin B / P P A + P B B / P P B / P B / P B / P P + / related B / P / A B / P B / P / A B / P / A B / P / A B/ P / A B / P / A B / P P B / P P + P / A P / A B / P / A P / A P / A B/ P / A P / A P / A B / P / A P / A B / P / A P / A related Framycetin B / P / A B / P / A + Aminosidine (=Paromo-) B / P / A B / P / A B / P / A +

Tetracyclines Oxy/ Chlor/ B / P / A / F B / P / A / F B / P / A B / P / A B / P / A / F B / P / A / F B / P / A / F B / P / A / F B / P / A B / P / A / F B / P / A / F B / P / A B / P / A /F5) + / related B / P / A B / P / A B / P / A B / P / A A B / P B / P / A +

Lincosamides B / P / A P / A P / A P / A P / A B / P / A P / A P / A B / P / A P B / P / A P / A P + / related

Macrolides /Spira-/ B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A P + / related Tilmicosin P P / A P P P P related B / P / A A NO A B / P / A +

Tiamulin P / A P / A P / A P / A P / A P P P / A P / A P / A P / A P P P NO P 4) P 4) P 4) P 4) P 4) P 4) P 4) P 4) P 4) P 4) P 4) P 4) P 4) P 4)

Polypeptide Antibiotics Polymyxin B / Colistin B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A B / P + / related Bacitracin B / P / A P B / P / A +

P = porcine; B = bovines; A = avian; F = Fish ãEMEA 1999 PAGE 1 OF 15 Annex I - Antibiotics used in Veterinary Medicine (January 1999)

TABLE 6 - cont. ANTIBIOTICS AUTHORISED FOR FOOD PRODUCING ANIMALS FOR IN THE EU - ORAL USE

Combination of active IT F SP EL PO UK IRE BE NL AU DE DK FIN SW Use in ingredients Humans Trimethoprim P / A F5) + Trimethoprim + Sulphonamide B / P / A / F B / P / A / F B / P / A B / P / A B / P / A / F B / P / A / F B / P / A B / P / A B / P / A B / P / A B / P / A / F B / P / F B / P B / P + Baquiloprim + Sulphonamide B B / P B B B B B related

Sulphonamides B / P / A / F B / P / A / F B / P / A B / P / A B / P / A B / P B / P / A B / P / A B / P / A B / P / A B / P / A / F B / P / A B / P B / P/ F5) +/ related

Quinolones Nalidixic acid B / P / A B / P / A P / A + / related first authorised in 1980 1979 Flumequin B / P / A / F B / P / A / F B / P / A B / A B / A A / F B / P / A / F F5) + / related 2) first authorised in 1989 < 1990 1979 1988 (1982) 1980 Oxolinic acid B / P / A B / P / A / F B / P / A B / P / A B / P / A F F A F F F5 + first authorised in 1988 < 1990 1988 1990 1983 1996 1990 1994 Pipemidic acid B / A B / A + first authorised in 1987

Fluoroquinolones Enrofloxacin B / P / A B / A B / P / A 3) B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A P 6) A Related first authorised in 1989 1991 1986 1990 1993 1988 1987 1992 1991 1991 1992 1988 Marbofloxacin 1) 1) B 1) 1) 1) related first authorised in (1993) 2) 1995 2) 2) 4) 4) 4) 4) 4) 4) 4) 4) 4) 4) 4) (1998) (1998) 3) 4) Difloxacin A A A A A A A A A A A4) A4) A A related first authorised in 1998 1998 1998 1998 1998 1998 1998 1998 1998 1998 1998 1998 1998 1998 3) Danofloxacin A A 3) related A first authorised in 2) 2) 2) 2) 2) 2) (1996) (1993) (1997) (1996) 1996 (1993) (1996) Sarafloxacin A F F + (in USA) first authorised in 1997 Orbifloxacin 1) first authorisation 19981)

Fenicols B / P / A +

Miscellaneous P / A related ) Authorised for companion animals 2) Authorised in food producing animals for parenteral use only 3) Authorised, but not on the market ) No information, whether on the market 5) Sweden: Use in fish only with special permission 6) Finland: Oral use of enrofloxacin in pigs was withdrawn in 1999

P = porcine; B = bovines; A = avian; F = Fish ãEMEA 1999 PAGE 2 OF 15 Annex I - Antibiotics used in Veterinary Medicine (January 1999)

TABLE 7 A: ANTIBIOTICS AUTHORISED FOR THERAPY IN CATTLE IN THE EU (all routes of administration)

Active Ingredient I F SP EL PO UK IRE BE NL GER AU DK SW FIN b-lactam Penicillins I, M I, M,T O, I, M, T I, M I, M I, M I, M I, M I, M O, I, M, T, U I, U, M I, M, T, U I, M I, M Ampicillin / Amoxycillin O, I, M O, I, M, U O, I, M O, I, U, M O, I, M O, I, O, I, M I, M O, I, M O, I, U, M O, I, M, U O, I, M O O, I, M Amoxyc. + Clavulanicac. I O, I, M O, I M O, I O, I, M O, I I O Isoxazolyl - Penicillins I, M M, U, T O, I, M I, M M M, T M, T M M I, M, U, T O, I, M, U,T M M (Met/Oxa/Di/Cloxa/Naf)

Cephalosporins I, M I, M, U O, I, M I, M I, M I, M, T I, M I, M I, M, U M, I I, M, U M, I I M

Aminoglycosides Dihydro / Streptomycin O, I, M I, M, U O, I I I, M I, M O, I, M I, M I, M O, I, M, U, T O, I, M, U O, I, M, U, T O, I, M O, I, M Neomycin O, T, M, U O, M O, I, M,T I, M O, M, T O, M, T O, M, T O, I, M O, I, M,T O, I, M, U, T O, I, M, U O, M M Kanamycin O, I, T, M I, I, M I I M I, M I, M, T I, U, M I Gentamicin I O, I, M, O, I, M I I, U, M I O, I, T O, I, U, M O, I Apramycin O, I O, I O, I O, I O, I O, I O, I O, I O Spectinomycin I I O, I I I O, I I I O, I O, I I Framycetin M O, I O, I, M, T M M I, M M M I, M M M M M Aminosidine (=Paromo-) O, I, M, T I O, I O, I I

Tetracyclines Oxy/Chlor/Tetracycline O, I, U O, I, M, T, U O, I, T, M O, I, U, T O, I, M, U,T O, I, M, T O, M, I, U,T I, T, U O, I, U,T O, I, M, U, T O, I, U, T O, M, I, U O, I O, I, T, M Doxycycline O, I O O, I O I O O, I

Lincosamides O, I I, U I, M I, M I, M O, I I I, M O, I, M O, I

Macrolides Tylosin/Erythro-/ O, I, M O, I, M O, I, M O, I, M O, I O, I, M O, M O, I O, I, M O, I, M O, I O, I I O, I, M Tilmicosin I I I I I I I I I I M M M M M I M Kitasamycin O, I Josamycin O

Tiamulin

Polypeptid Antibiotics Polymyxin B / Colistin O, I O, I, M O, I, M O, I, T O, I, M, T O, I, M O, I, M O, I, M, U U, M O Bacitracin I O M O M

O = oral; I = Injection; U = intrauterine; M = intramammary; T = topical ãEMEA 1999 PAGE 3 OF 15 Annex I - Antibiotics used in Veterinary Medicine (January 1999)

TABLE 7 A - contin.: ANTIBIOTICS AUTHORISED FOR THERAPY IN CATTLE IN THE EU (all routes of administration)

Active Ingredient I F SP EL PO UK IRE BE NL GER AU DK SW FIN

Trimethoprim I M Trimethoprim + Sulphonamide O, I, M O, I, O, I, M O, I O, I, M, U O, I O, I O, I O, I O, I O, U O, I O, I O, I Baquiloprim + Sulphonamide O, I O, I O, I O O O O, I

Sulfonamides O, I, T O, I, U, T O, I, M, T O, I O, I, M, U O, I O, I, T O, I O, I, M O, I, M, U, T O, I, T O, I, U, T O, I, T O, I, T

Quinolones Nalidixic acid O O Flumequin O, I O, I O, I O O, I I O, I Oxolinic acid O O O O O Pipemidic acid O O

Fluoroquinolons Enrofloxacin O, I O, I O, I O, I O, I O, I O, I O, I O, I O, I, U O, I, U O, I I I Marbofloxacin I O, I I I Danofloxacin I I I I I I I I I

Fenicols I I I I I I I I I I I I Thiamphenicol O, I, U T T

Miscellaneous Novobiocin M M M M M M M M M Rifampicin M, U M U M

O = oral; I = Injection; U = intrauterine; M = intramammary; T = topical ãEMEA 1999 PAGE 4 OF 15 Annex I - Antibiotics used in Veterinary Medicine (January 1999)

TABLE 7 B: ANTIBIOTICS AUTHORISED FOR ORAL USE IN CATTLE IN THE EU

Active Ingredient I F SP EL PO UK IRE BE NL GER AU DK SW FIN b-lactam Penicillins X X Ampicillin / Amoxycillin X X X X X X X X X X X X X Amoxyc. + Clavulanicac. X X X X X X Isoxazolyl - Penicillins X X (Met/Oxa/Di/Cloxa/Naf)

Cephalosporins X

Aminoglycosides Dihydro / Streptomycin X X X X X X X Neomycin X X X X X X X X X X X Kanamycin X Gentamicin X X X X X Apramycin X X X X X X X X X Spectinomycin X X X X Framycetin X X Aminosidine (=Paromo-) X X X

Tetracyclines Oxy/Chlor/Tetracycline X X X X X X X X X X X X X Doxycycline X X X X X X

Lincosamides X X X X

Macrolides Tylosin/Erythro-/Spiramycin X X X X X X X X X X X X X Kitasamycin X Josamycin X

Polypeptid Antibiotics Polymyxin B / Colistin X X X X X X X X X Bacitracin X X

ãEMEA 1999 PAGE 5 OF 15 Annex I - Antibiotics used in Veterinary Medicine (January 1999)

TABLE 7 B - contin.: ANTIBIOTICS AUTHORISED FOR ORAL USE IN CATTLE IN THE EU

Active Ingredient I F SP EL PO UK IRE BE NL GER AU DK SW FIN

Trimethoprim + Sulphonamide X X X X X X X X X X X X X X Baquiloprim + Sulphonamide X X X X X X X

Sulfonamides X X X X X X X X X X X X X X

Quinolones Nalidixic acid X X Flumequin X X X X X X Oxolinic acid X X X X X Pipemidic acid X X

Fluoroquinolones Enrofloxacin X X X X X X X X X X X X Marbofloxacin X

Fenicols Thiamphenicol X

ãEMEA 1999 PAGE 6 OF 15 Annex I - Antibiotics used in Veterinary Medicine (January 1999)

TABLE 8 A: ANTIBIOTICS AUTHORISED FOR THERAPY IN PIGS IN THE EU (all routes of administration)

Active Ingredient I F SP EL PO UK IRE BE NL GER AU DK SW FIN

b-lactam Penicillins I I O, I O, I I, M O, I, T O, I I I O,I, T, U I, M I, T I I Ampicillin / Amoxycillin O, I O , I O, I, O, I O, I O, I O , I O, I O, I O, I, U O, I O, I O, I O, I Amoxycillin+Clavulanicacid O Isoxazolyl - Penicillins I O I (Met/Oxa/Di/Cloxa/Naf)

Cephalosporins I I O, I I I I I I I I I

Aminoglycosides Dihydro / Streptomycin O, I I O, I I I I I I I O, I,U T O, I O,U,I, T O, I I Neomycin O, T O O, I I O, T O, T O, T O, I O, I,T O,I,U,T O, I, U O Kanamycin O, I, T, O, I I I I I I, U I Gentamicin O,I O, I I O, I I O, I, T O, I, O, I O Apramycin O, I O O, I O O O, I O O , O O O Spectinomycin O, I O , I O, I O,I O, I O, I O , I O, I O, I O, I O, I O, I Framycetin O O, I, T I I Aminosidine (=Paromo-) O, I, T O, I O, I Amikacin I

Tetracyclines Oxy-/Chlor-/Tetracycline O, I O, I,U,T O, I, T O,I, T O, I, U, T O, I O , I, T I, U O, I U,T O,I,U,T O, I, U, T O, I O, I O, I, T Doxycycline O, I O O, I O I O O, I

Lincosamides O, I O , I O, I O,I O, I O, I O , I O , I O, I O, I O O, I O, I

Macrolides Tylosin/Erythro-/Spiramycin O, I O , I O, I O, I O, I O, I O , I O, I O, I O, I O, I O, I O, I O, I Tilmicosin O O , I O I O O O Kitasamycin O, I Josamycin O

Tiamulin O, I O , I O, I O, I O, I O, I O , I O O, I O, I O O, I O, I O Valnemulin O 1) O 1) O 1) O 1) O 1) O 1) O 1) O 1) O 1) O 1) O 1) O 1) O 1) O 1)

Polypeptid Antibiotics Polymyxin B / Colistin O, I O ,I O, I O, T O, I, T O, I O, I O,I, U O Bacitracin O O O

O = oral; I = Injection; U = intrauterine; M = intramammary; T = topical 1) Valnemulin: Authorised in 1999 (centralised procedure), no information whether on the market 2) Finland: Enrofloxacin: Oral use in pigs withdrawn in 1999 ãEMEA 1999 PAGE 7 OF 15 Annex I - Antibiotics used in Veterinary Medicine (January 1999)

TABLE 8 A - contin.: ANTIBIOTICS AUTHORISED FOR THERAPY IN PIGS IN THE EU (all routes of administration)

Active Ingredient I F SP EL PO UK IRE BE NL GER AU DK SW FIN

Trimethoprim O Trimethoprim + Sulphonamide O, I O , I O, I O O, I O, I O , I O, I O, I O, I O O, I O, I O, I Baquiloprim + Sulphonamide O, I

Sulfonamides O, I, T O ,I,T O, I, T O, I O, I O, I O , I, T O, I O, I O, I, U, T O, I, T O, I, T O, I, T O, I, T

Quinolones Nalidixic acid O O O Flumequin O, I O , I O, I I I O, I Oxolinic acid O O O O O

Fluoroquinolons Enrofloxacin O, I O,I O, I O, I O, I O , I O, I O, I O, I O, I O, I I 2) I Marbofloxacin I I I

Fenicols Thiamphenicol O T T

Miscellaneous Virginiamycin O Rifaximine U

O = oral; I = Injection; U = intrauterine; M = intramammary; T = topical 1) Valnemulin: Authorised in 1999 (centralised procedure), no information whether on the market 2) Finland: Enrofloxacin: Oral use in pigs withdrawn in 1999 ãEMEA 1999 PAGE 8 OF 15 Annex I - Antibiotics used in Veterinary Medicine (January 1999)

TABLE 8 B: ANTIBIOTICS AUTHORISED FOR ORAL USE IN PIGS IN THE EU

Active Ingredient I F SP EL PO UK IRE BE NL GER AU DK SW FIN

b-lactam Penicillins X X X X X Ampicillin / Amoxycillin X X X X X X X X X X X X X X Amoxycillin+clavulanic acid X Isoxazolyl - Penicillins X (Met/Oxa/Di/Cloxa/Naf)

Cephalosporins X

Aminoglycosides Dihydro / Streptomycin X X X X X X Neomycin X X X X X X X X X X X Kanamycin X X Gentamicin X X X X X X X Apramycin X X X X X X X X X X X Spectinomycin X X X X X X X X X X X X Framycetin X X Aminosidine (=Paromo-) X X X

Tetracyclines Oxy-/Chlor-/Tetracycline X X X X X X X X X X X X X Doxycycline X X X X X X

Lincosamides X X X X X X X X X X X X X

Macrolides Tylosin/Erythro-/Spiramycin X X X X X X X X X X X X X X Tilmicosin X X X X X X Kitasamycin X Josamycin X

Tiamulin X X X X X X X X X X X X X X Valnemulin 1) X 1) X1) X1) X1) X1) X1) X1) X1) X1) X1) X1) X1) X1) X1)

Polypeptid Antibiotics Polymyxin B / Colistin X X X X X X X X X Bacitracin X X X

1) Valnemulin: Authorised in 1999 (centralised procedure), no information whether on the market ãEMEA 1999 PAGE 9 OF 15 Annex I - Antibiotics used in Veterinary Medicine (January 1999)

TABLE 8 B - contin.: ANTIBIOTICS AUTHORISED FOR ORAL USE IN PIGS IN THE EU

Active Ingredient I F SP EL PO UK IRE BE NL GER AU DK SW FIN

Trimethoprim X Trimethoprim + Sulphonamide X X X X X X X X X X X X X X Baquiloprim + Sulphonamide X

Sulphonamides X X X X X X X X X X X X X X

Quinolones Nalidixic acid X X X Flumequin X X X X Oxolinic acid X X X X X

Fluoroquinolone Enrofloxacin X X X X X X X X X X X 2)

Fenicols Thiamphenicol X

Miscellaneous Virginiamycin X

1) Valnemulin: Authorised in 1999 (centralised procedure), no information whether on the market 2) Finland: Enrofloxacin: Oral use in pigs withdrawn in 1999

1) Valnemulin: Authorised in 1999 (centralised procedure), no information whether on the market ãEMEA 1999 PAGE 10 OF 15 Annex I - Antibiotics used in Veterinary Medicine (January 1999)

TABLE 9 A: ANTIBIOTICS AUTHORISED FOR THERAPY IN POULTRY IN THE EU (all routes of administration)

Active Ingredient I F SP EL PO UK IRE BE NL GER AU DK SW FIN

b-lactam Penicillins I O, I I O, I, Ampicillin / Amoxycillin O, I O, I O, I O O O, I O O O, I O Amoxycillin+Clavulanicacid O, I

Cephalosporins I I

Aminoglycosides Dihydro / Streptomycin I I O, I I I I O, I I O Neomycin O O O, I O O O O, T O, I, T O, T O, I O Kanamycin I, T O I Gentamicin I I I Apramycin O O O O O, I O Spectinomycin O, I O O, I O O, I, T O, I O, I, T O , I O, I O, I O, I O Framycetin O O, I Aminosidine (=Paromo-) O O O Amikacin I

Tetracyclines Oxy/Chlor/Tetracycline O, I O , I O, I, T O, I, T O, I, T O, I O, T O, I, T O, I O, I, T O O, I O, I, T Doxycycline O, I O O O O O, I

Lincosamides O, I O, I O, I O,I O, I O, I O O , I O, I O, I

Macrolides Tylosin/Erythro-/Spiramycin O, I O, I O, I O, I O O, I O O , I O, I O, I O, I O O, I Tilmicosin O Kitasamycin O O Josamycin O

Tiamulin O O O O O O O, I O O

Polypeptid Antibiotics Polymyxin B / Colistin O, I O ,I O O O O I O, I O I Bacitracin O O

O = oral; I = Injection; U = intrauterine; M = intramammary; T = topical ãEMEA 1999 PAGE 11 OF 15 Annex I - Antibiotics used in Veterinary Medicine (January 1999)

TABLE 9 A - contin.: ANTIBIOTICS AUTHORISED FOR THERAPY IN POULTRY IN THE EU (all routes of administration)

Active Ingredient I F SP EL PO UK IRE BE NL GER AU DK SW FIN

Trimethoprim O Trimethoprim + Sulphonamide O, I O O, I O O, I O, I O O O, I O O

Sulfonamides O, I, T O , I O, I O O, I O, T O O, I O, I O, T O

Quinolones Nalidixic acid O O O Flumequin O, I O , I O O O, I O O Oxolinic acid O O O O O O Pipemidic acid O O

Fluoroquinolons Enrofloxacin O O O2 ), I O O O O O O, I O O O O, I Difloxacin 1) O 1) O1) O1) O1) O1) O1) O1) O1) O1) O1) O1) O1) O1) O2) Danofloxacin O 2) O O2 ) Sarafloxacin O

Fenicols Thiamphenicol O T

Miscellaneous Virginiamycin T O

1) Authorised (centralised procedure), no information whether it is on the market 2 ) Authorised, but not on the market

O = oral; I = Injection; U = intrauterine; M = intramammary; T = topical ãEMEA 1999 PAGE 12 OF 15 Annex I - Antibiotics used in Veterinary Medicine (January 1999)

TABLE 9 B: ANTIBIOTICS AUTHORISED FOR ORAL USE IN POULTRY IN THE EU

Active Ingredient I F SP EL PO UK IRE BE NL GER AU DK SW FIN b-lactam Penicillins X X Ampicillin / Amoxycillin X X X X X X X X X X Amoxycillin+Clavulanicacid X

Aminoglycosides Dihydro / Streptomycin X X X Neomycin X X X X X X X X X X X Kanamycin X Apramycin X X X X X X Spectinomycin X X X X X X X X X X X X Framycetin X X Aminosidine (=Paromo-) X X X

Tetracyclines Oxy/Chlor/Tetracycline X X X X X X X X X X X X X Doxycycline X X X X X X

Lincosamides X X X X X X X X X X

Macrolides Tylosin/Erythro-/Spiramycin X X X X X X X X X X X X X Tilmicosin X Kitasamycin X X Josamycin X

Tiamulin X X X X X X X X X

Polypeptid Antibiotics Polymyxin B / Colistin X X X X X X X X Bacitracin X X

ãEMEA 1999 PAGE 13 OF 15 Annex I - Antibiotics used in Veterinary Medicine (January 1999)

TABLE 9 B - contin.: ANTIBIOTICS AUTHORISED FOR ORAL USE IN POULTRY IN THE EU

Active Ingredient I F SP EL PO UK IRE BE NL GER AU DK SW FIN

Trimethoprim X Trimethoprim + Sulphonamide X X X X X X X X X X X

Sulfonamides X X X X X X X X X X X

Quinolones Nalidixic acid X X X Flumequin X X X X X X X Oxolinic acid X X X X X X Pipemidic acid X X

Fluoroquinolons Enrofloxacin X X X2) X X X X X X X X X X Difloxacin 1) X 1) X1) X1) X1) X1) X1) X1) X1) X1) X1) X1) X1) X1) X2) Danofloxacin X 2) X X 2) Sarafloxacin X

Fenicols Thiamphenicol X

Miscellaneous Virginiamycin X

) Authorised (centralised procedure), no information whether it is on the market ) Authorised, but not on the market

ãEMEA 1999 PAGE 14 OF 15 Annex I - Antibiotics used in Veterinary Medicine (January 1999)

TABLE 10: ANTIBIOTICS AUTHORISED FOR ORAL USE IN FISH IN THE EU

Active Ingredient I F SP EL UK IRE NL GER DK SW1) FIN PO BE AU (N) Human Use b-lactams Ampicillin / Amoxicillin X X X +

Tetracyclines Oxy/ Chlor/ Tetracycline X X X X X X X1) X X X +

Trimethoprim X X1) + Trimethoprim + Sulph. X X X X (X)

Sulphonamides X X X X (X) 1) +

Quinolones Flumequin X X X X (X) 1) X related Oxolinic acid X X X X X1) X X +

Fluoroquinolones + Sarafloxacin X X (in USA)

Fenicols Florfenicol X related

(X): use in fish within the last 3 year = 0 No information available from Greece, Netherlands, Belgium, Austria

1) Swedish data: Use of antibiotics in fish only with special permission

ãEMEA 1999 PAGE 15 OF 15

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