Antibiotic Resistance in the European Union Associated with Therapeutic use of Veterinary Medicines Report and Qualitative Risk Assessment by the Committee for Veterinary Medicinal Products Annex I Antibiotics authorised for Therapy in Food Producing Animals in the EU (Tables 6 - 10) ãEMEA 1999 Annex I - Antibiotics used in Veterinary Medicine (January 1999) TABLE 6 ANTIBIOTICS AUTHORISED FOR FOOD PRODUCING ANIMALS IN THE EU - ORAL USE Combination of active IT F SP EL PO UK IRE BE NL AU DE DK FIN SW Use in ingredients Humans b-lactam Penicillins B / P / A P P P B / P / A + Ampicillin / Amoxycillin B / P / A B / P / A B / P / A B / P /A B / P / A B / P / A / F B / P / A / F P / A B / P / A B / P B / P / A B / P / F B / P B / P + Amoxycillin+clavulanic acid B B / A P B B B B + Isoxazolyl - Penicillins B / P B + (Met/Oxa/Di/Cloxa/Naf) Cephalosporins B / P P + / related Aminoglycosides Dihydro / Streptomycin B / P B / P / A B B / P B / P / A B / P / A B B / P + / related Neomycin B / P / A B / P / A B / P / A A B / P / A B / P / A B / P / A B / P B / P / A B / P / A B / P / A B / P / A related Kanamycin B / P P A + Gentamicin P B B / P P B / P B / P B / P P + / related Apramycin B / P / A B / P B / P / A B / P / A B / P / A B/ P / A B / P / A B / P P B / P P + Spectinomycin P / A P / A B / P / A P / A P / A B/ P / A P / A P / A B / P / A P / A B / P / A P / A related Framycetin B / P / A B / P / A + Aminosidine (=Paromo-) B / P / A B / P / A B / P / A + Tetracyclines Oxy/ Chlor/ Tetracycline B / P / A / F B / P / A / F B / P / A B / P / A B / P / A / F B / P / A / F B / P / A / F B / P / A / F B / P / A B / P / A / F B / P / A / F B / P / A B / P / A /F5) + / related Doxycycline B / P / A B / P / A B / P / A B / P / A A B / P B / P / A + Lincosamides B / P / A P / A P / A P / A P / A B / P / A P / A P / A B / P / A P B / P / A P / A P + / related Macrolides Tylosin/Spira-/Erythromycin B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A P + / related Tilmicosin P P / A P P P P related Kitasamycin B / P / A A NO Josamycin A B / P / A + Tiamulin P / A P / A P / A P / A P / A P P P / A P / A P / A P / A P P P NO Valnemulin P 4) P 4) P 4) P 4) P 4) P 4) P 4) P 4) P 4) P 4) P 4) P 4) P 4) P 4) Polypeptide Antibiotics Polymyxin B / Colistin B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A B / P + / related Bacitracin B / P / A P B / P / A + P = porcine; B = bovines; A = avian; F = Fish ãEMEA 1999 PAGE 1 OF 15 Annex I - Antibiotics used in Veterinary Medicine (January 1999) TABLE 6 - cont. ANTIBIOTICS AUTHORISED FOR FOOD PRODUCING ANIMALS FOR IN THE EU - ORAL USE Combination of active IT F SP EL PO UK IRE BE NL AU DE DK FIN SW Use in ingredients Humans Trimethoprim P / A F5) + Trimethoprim + Sulphonamide B / P / A / F B / P / A / F B / P / A B / P / A B / P / A / F B / P / A / F B / P / A B / P / A B / P / A B / P / A B / P / A / F B / P / F B / P B / P + Baquiloprim + Sulphonamide B B / P B B B B B related Sulphonamides B / P / A / F B / P / A / F B / P / A B / P / A B / P / A B / P B / P / A B / P / A B / P / A B / P / A B / P / A / F B / P / A B / P B / P/ F5) +/ related Quinolones Nalidixic acid B / P / A B / P / A P / A + / related first authorised in 1980 1979 Flumequin B / P / A / F B / P / A / F B / P / A B / A B / A A / F B / P / A / F F5) + / related 2) first authorised in 1989 < 1990 1979 1988 (1982) 1980 Oxolinic acid B / P / A B / P / A / F B / P / A B / P / A B / P / A F F A F F F5 + first authorised in 1988 < 1990 1988 1990 1983 1996 1990 1994 Pipemidic acid B / A B / A + first authorised in 1987 Fluoroquinolones Enrofloxacin B / P / A B / A B / P / A 3) B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A B / P / A P 6) A Related first authorised in 1989 1991 1986 1990 1993 1988 1987 1992 1991 1991 1992 1988 Marbofloxacin 1) 1) B 1) 1) 1) related first authorised in (1993) 2) 1995 2) 2) 4) 4) 4) 4) 4) 4) 4) 4) 4) 4) 4) (1998) (1998) 3) 4) Difloxacin A A A A A A A A A A A4) A4) A A related first authorised in 1998 1998 1998 1998 1998 1998 1998 1998 1998 1998 1998 1998 1998 1998 3) Danofloxacin A A 3) related A first authorised in 2) 2) 2) 2) 2) 2) (1996) (1993) (1997) (1996) 1996 (1993) (1996) Sarafloxacin A F F + (in USA) first authorised in 1997 Orbifloxacin 1) first authorisation 19981) Fenicols Thiamphenicol B / P / A + Miscellaneous Virginiamycin P / A related ) Authorised for companion animals 2) Authorised in food producing animals for parenteral use only 3) Authorised, but not on the market ) No information, whether on the market 5) Sweden: Use in fish only with special permission 6) Finland: Oral use of enrofloxacin in pigs was withdrawn in 1999 P = porcine; B = bovines; A = avian; F = Fish ãEMEA 1999 PAGE 2 OF 15 Annex I - Antibiotics used in Veterinary Medicine (January 1999) TABLE 7 A: ANTIBIOTICS AUTHORISED FOR THERAPY IN CATTLE IN THE EU (all routes of administration) Active Ingredient I F SP EL PO UK IRE BE NL GER AU DK SW FIN b-lactam Penicillins I, M I, M,T O, I, M, T I, M I, M I, M I, M I, M I, M O, I, M, T, U I, U, M I, M, T, U I, M I, M Ampicillin / Amoxycillin O, I, M O, I, M, U O, I, M O, I, U, M O, I, M O, I, O, I, M I, M O, I, M O, I, U, M O, I, M, U O, I, M O O, I, M Amoxyc. + Clavulanicac. I O, I, M O, I M O, I O, I, M O, I I O Isoxazolyl - Penicillins I, M M, U, T O, I, M I, M M M, T M, T M M I, M, U, T O, I, M, U,T M M (Met/Oxa/Di/Cloxa/Naf) Cephalosporins I, M I, M, U O, I, M I, M I, M I, M, T I, M I, M I, M, U M, I I, M, U M, I I M Aminoglycosides Dihydro / Streptomycin O, I, M I, M, U O, I I I, M I, M O, I, M I, M I, M O, I, M, U, T O, I, M, U O, I, M, U, T O, I, M O, I, M Neomycin O, T, M, U O, M O, I, M,T I, M O, M, T O, M, T O, M, T O, I, M O, I, M,T O, I, M, U, T O, I, M, U O, M M Kanamycin O, I, T, M I, I, M I I M I, M I, M, T I, U, M I Gentamicin I O, I, M, O, I, M I I, U, M I O, I, T O, I, U, M O, I Apramycin O, I O, I O, I O, I O, I O, I O, I O, I O Spectinomycin I I O, I I I O, I I I O, I O, I I Framycetin M O, I O, I, M, T M M I, M M M I, M M M M M Aminosidine (=Paromo-) O, I, M, T I O, I O, I Amikacin I Tetracyclines Oxy/Chlor/Tetracycline O, I, U O, I, M, T, U O, I, T, M O, I, U, T O, I, M, U,T O, I, M, T O, M, I, U,T I, T, U O, I, U,T O, I, M, U, T O, I, U, T O, M, I, U O, I O, I, T, M Doxycycline O, I O O, I O I O O, I Lincosamides O, I I, U I, M I, M I, M O, I I I, M O, I, M O, I Macrolides Tylosin/Erythro-/Spiramycin O, I, M O, I, M O, I, M O, I, M O, I O, I, M O, M O, I O, I, M O, I, M O, I O, I I O, I, M Tilmicosin I I I I I I I I I I Oleandomycin M M M M M I M Kitasamycin O, I Josamycin O Tiamulin Polypeptid Antibiotics Polymyxin B / Colistin O, I O, I, M O, I, M O, I, T O, I, M, T O, I, M O, I, M O, I, M, U U, M O Bacitracin I O M O M O = oral; I = Injection; U = intrauterine; M = intramammary; T = topical ãEMEA 1999 PAGE 3 OF 15 Annex I - Antibiotics used in Veterinary Medicine (January 1999) TABLE 7 A - contin.: ANTIBIOTICS AUTHORISED FOR THERAPY IN CATTLE IN THE EU (all routes of administration) Active Ingredient I F SP EL PO UK IRE BE NL GER AU DK SW FIN Trimethoprim I M Trimethoprim + Sulphonamide O, I, M O, I, O, I, M O, I O, I, M, U O, I O, I O, I O, I O, I O, U O, I O, I O, I Baquiloprim + Sulphonamide O, I O, I O, I O O O O, I Sulfonamides O, I, T O, I, U, T O, I, M, T O, I O, I, M, U O, I O, I, T O, I O, I, M O, I, M, U, T O, I, T O, I, U, T O, I, T O, I, T Quinolones Nalidixic acid O O Flumequin O, I O, I O, I O O, I I O, I Oxolinic acid O O O O O Pipemidic acid O O Fluoroquinolons Enrofloxacin O, I O, I O, I O, I O, I O, I O, I O, I O, I O, I, U O, I, U O, I I I Marbofloxacin I O, I I I Danofloxacin I I I I I I I I I Fenicols Florfenicol I I I I I I I I I I I I Thiamphenicol O, I, U T T Miscellaneous Novobiocin M M M M M M M M M Rifampicin M, U M U M O = oral; I = Injection; U = intrauterine; M = intramammary; T = topical ãEMEA 1999 PAGE 4 OF 15 Annex I - Antibiotics used in Veterinary Medicine (January 1999) TABLE 7 B: ANTIBIOTICS AUTHORISED FOR ORAL USE IN CATTLE IN THE EU Active Ingredient I F SP EL PO UK IRE BE NL GER AU DK SW FIN b-lactam Penicillins X X Ampicillin / Amoxycillin X X X X X X X X X X X X X Amoxyc.