Index
Altered genes for growth factors Clearance of IgA immune Contractile cells in pulmonary and receptors: 195, 196 complexes: 117 fibrosis: 27-29 -c-ERBB-J: 195 Clinical aspects of folate-binding -animal models of fibrosis: -c-ERBB-2: 195, 196 proteins: 40, 41 28,29 -other growth factors and Clinical immunology of IgA -human fibrotic lungs: 27, 28 receptors: 196 nephropathy: 115 Cytogenetic aberrations in cancer: Altered tyrosine kinases: 196, 197 Clinical significance of anti-GBM: 157-160 -c-ABL and CML: 196, 197 147, 148 -Burkitt lymphoma: 158 -hematopoietic-specific Comparison between human and rat -early discoveries: 157 tyrosine kinases: 197 mammary tumors: 235-246 -Ewing's tumor: 158, 159 -other tyrosine kinases: 197 --criteria of malignancy: -follicular lymphoma: 158 Animal models of glomerulo• 245,246 -fragile sites: 158 nephritis: 144, 145 -histopathologic classification -gene amplification: 159 -immunization: 144, 145 of mammary tumors: 235, 236 -Philadelphia chromosome: -polyclonal B cell stimulation: -immunocytochemical markers 157, 158 145 in the normal human breast -small cell carcinoma of the Anti-basement membrane and its tumors: 241-245 lung: 159 antibodies and dense -immunocytochemical markers - T cell neoplasia: 158 aggregate formation: 146, 147 in the normal rat mammary DNA repair deficient disorders: Antigen as a factor in nephrito• gland and in its tumors: 180-183 genesis: 122 238-241 -Bloom's syndrome: 182 BCL and TCL gene rearrange• -immunocytochemistry of the -Cockayne's syndrome: 183 ments in lymphomas/ normal mammary gland and of -Fanconi's anemia: 182 leukemias: 197 its neoplasms: 237 -xeroderma pigmentosum: 181 The biochemical interrelationship Conditions suspect for DNA repair DNA repair mechanisms in of the soluble and membrane• deficiency: 183, 184 mammalian cells: 172-176 associated folate-binding -ataxia telangiectasia: 183 -DNA damage and repair: proteins: 43-45 - 253 254 INDEX -development of the rat -methods to assess intercellular Multidisciplinary origins of IL-6 mammary gland: 223-226 communication: 208 research: 97, 98 Etiologic factors in immunologi• -inhibition of intercellular Nuclear oncoproteins as cancer cally mediated glomerulo• communication by non• markers: 193-195 nephritis: 143, 144 genotoxic carcinogens: -c-MYC gene: 194 The existence of stern cells in 208-211 -N-MYC: 193 normal liver: 9 -mechanisms of inhibition of -p53 gene alterations in Experimentally-induced mammary intercellular communication osteogenic sarcomas and tumors in rats: 218-223 by tumor promoters and CML: 194, 195 ---chemically-induced mammary nongenotoxic carcinogens: -RAS oncogene proteins as tumorigenesis: 218-222 211,212 cancer markers: 195 -radiation-induced mammary Liver regeneration after partial Oncogenes: 155-157 tumorigenesis: 222, 223 hepatectomy: 4 -early discoveries: 155, 156 Folate-binding protein: Mast cell heterogeneity: 53~7 Oncogenes and the neoplastic state: -definition: 39,40 -alternative mechanisms which 156, 157 -physiologic saturable might account for mast cell -the summing up: 157 membrane transport system heterogeneity: 57-59 Oncogenes as growth and for folates: 41-43 --evidence for heterogeneity of differentiation genes: 156 Gene deletion and antioncogenes: mast cell phenotypic charac• Origin, distribution and character• 197, 198 teristics in vivo: 53-57 istics of basophils and mast Genetic organization of MHC: 83 Matrix vesicle biogenesis: 18, 19 cells: 50-53 -HLA class II genes are located Microenvironmental regulation of -basophil origin and in three major subregions: mast cell development and distribution: 50, 51 83,84 phenotype: 59-67 -mast cells origin and -relationship of class II genes Mineralization mechanism in distribution: 50,51 to serologically defined HLA embryonic bone: 15-17 -relationship between basophils class II alleles: 84 Molecular architecture of and mast cells: 52, 53 Growth factors and liver membrane Goodpasture Pathogenesis of mammary regeneration: 5 antigen: 134-136 tumors: 231 Hepatocyte replication as a ---cryptic properties of ---comparative aspects of patho• response to cell death: 8,9 Goodpasture determinant(s): genesis: 234, 235 Heterogeneity of DNA repair 135,136 -human breast tumors: 232-234 -preferential DNA repair in -organization of protomer -rat mammary tumors: 231, 232 mammalian cells: 177-179 subtypes: 134, 135 Pathogenesis of IgA nephropathy: The IL-6 receptor: 101 -protomer structure: 134 118, 119 Immunoglublin and T cell receptor -supramolecular structure: 134 Pathogenetic mechanisms: 145, 146 gene rearrangements: 197 Molecular cloning and expression: Pathophysiology of IgA Inducible responses to DNA 98-100 nephropathy: 119, 120 damage: 179, 180 Molecular identity of GBM antigen: Perspectives: 185, 186 Intercellular communication: 130,134 -aging: 185 206-212 -identity of membrane -DNA repair and neuro- -gap junction structure and Goodpasture antigen: 131, 132 degenerative diseases: 185 intercellular communication: -properties of collagenase• -risk of cancer: 185 208-211 solubilized Goodpasture Possible functions of Goodpasture -regulation of gap junction antigen: 131 antigen: 136, 137 formation and permeability: -specificity of Goodpasture -role of DNA damage in 207 antibodies: 132 atherosclerosis: 186 ---cellular function of gap Molecular markers in cancer -role of DNA repair and DNA junction-mediated inter• diagnosis: 198, 199 damage-inducible responses cellular communication: The mucosal immune system and in chemoresistant tumor 207,208 properties of IgA: 116, 117 cells: 186 INDEX 255 Polymorphism within DQ phospholipids in vesicle subregion: 89-92 calcification: 17, 18 -DQa chain Role of transforming growth polymorphism: 92 factors a and ~ in liver -DQa I~ combinatorial regeneration: 6 diversity: 90, 91 - TOF-a: autocrine stimulation -DQ~ polymorphism: 90 of hepatocyte growth: 7 -susceptibility to insulin - TOF-~: negative control of dependent diabetes mellitus: hepatocyte replication: 6 91,92 Roles of IL-6 in diseases: 105, 106 Polymorphism within DR Similar third diversity region subregion: 85-89 polymorphisms may be _H_2bmI2 mouse: 88 functionally equivalent even -sequence variation of DR~ when present on different chains: 85-88 DRI5 alleles: 89 -third diversity region DR~ -third diversity region poly• polymorphisms influence morphisms in DR chain may T cell responsiveness: 88 confer risk for rheumatoid Priming of hepatocytes by arthiritis: 89 nutritional changes: 7, 8 Soluble folate-binding protein: 43 Proliferation of filament-laden cells Stages of chemical carcinogenesis: in granulation tissue: 29-32 205,206 -what are the stimuli for prolif• Stages of liver regeneration: 4, 5 eration of microfilament• Structure and function of HLA containing cells in injured molecules: 82, 83 lung?: 31, 32 --class II molecules bind anti• -what is the origin of filament• genic peptide fragments: 82 laden cells in remodeling -structural features of HLA tissue?: 30, 31 molecules: 82 Protooncogene expression during - T cells recognize "processed" liver regeneration: 4 fragments of foreign antigen Recessive mutations and cancer: bound to HLA molecules: 160--165 82,83 -the basis for the recessive Therapy for IgA nephropathy: 116 oncogene concept: 160 -Beckwith-Wiedemann syndrome: 162 --colorectal cancer and familial polyposis: 163 -neurofibromatosis: 163 -other cancers: 164, 165 -other childhood cancers: 162, 163 -retinoblal)toma and osteosarcoma: 160, 161 -Wilms'tumor: 161, 162 Regulation of gene expression: 100,101 Role of different classes of antibody: 120,121 Role of phosphatase and membrane