July 25, 2017 u vol. 114 u no. 30

From the Cover

7775 Social learning and evolution E6089 Population declines in vertebrates 7929 Volcanism and end-Triassic mass extinction 8035 Self-organization and resilience in ecosystems

Contents

THIS WEEK IN PNAS 7731 In This Issue

Cover image: A juvenile capuchin monkey observes a skilled adult male LETTERS (ONLINE ONLY) eating a nut it has just broken using E6027 Reappraisal of dioxygen binding in NOV1 crystal structures a hammerstone. Articles in the Sackler Philip D. Kiser Colloquium on the Extension of Biology Through Culture explore social learning E6029 Reply to Kiser: Dioxygen binding in NOV1 crystal structures and cultural transmission in humans and Ryan P. McAndrew, Noppadon Sathitsuksanoh, Michael M. Mbughuni, Richard A. Heins, Jose H. Pereira, Anthe George, Kenneth L. Sale, Brian G. Fox, Blake A. Simmons, nonhuman animals as well as the and Paul D. Adams interplay between cultural and genetic evolution. See the Introduction to the E6031 Linking brain networks and behavioral variability to different types Sackler Colloquium by Andrew Whiten of mind-wandering et al. on pages 7775–7781. Image Ga´bor Csifcsa´k and Matthias Mittner courtesy of Luca Antonio Marino E6033 Reply to Csifcsák and Mittner: Fitting data to neural models of mind-wandering (EthoCebus Project, Brazil). Aaron Kucyi, Michael Esterman, and Eve M. Valera

NEWS FEATURE—An in-depth look at trending science issues 7734 Can animal culture drive evolution? Carolyn Beans

PROFILE 7738 Profile of Stephen C. West Paul Gabrielsen See Inaugural Article on page 443 in issue 3 of volume 114

COMMENTARIES 7741 Different phosphodiesterases (PDEs) regulate distinct phosphoproteomes during cAMP signaling Paul M. Epstein See companion article on page E6240 7744 Uncoupling protein 1 controls reactive oxygen species in brown adipose tissue Martin Jastroch See companion article on page 7981 7747 Regular patterns link individual behavior to population persistence Frederic Guichard See companion article on page 8035

Free online through the PNAS open access option. PNAS u July 25, 2017 u vol. 114 u no. 30 u iii–viii Downloaded by guest on September 27, 2021 7750 Big-time insights from a tiny bird fossil 7861 Evolutionary neuroscience of cumulative culture Daniel J. Field Dietrich Stout and Erin E. Hecht See companion article on page 8047 7869 Identifying early modern human ecological niche expansions and associated cultural dynamics in PNAS PLUS the South African Middle Stone Age Francesco d’Errico, William E. Banks, Dan L. Warren, Giovanni 7753 Significance Statements Sgubin, Karen van Niekerk, Christopher Henshilwood, Brief statements written by the authors about the significance of their Anne-Laure Daniau, and Marı´a Fernanda Sa´nchez Gon˜i papers. 7877 Cumulative cultural learning: Development and diversity PERSPECTIVE Cristine H. Legare 7758 Why eyewitnesses fail 7884 Young children communicate their ignorance and Thomas D. Albright ask questions Paul L. Harris, Deborah T. Bartz, and Meredith L. Rowe INAUGURAL ARTICLE 7892 Changes in cognitive flexibility and hypothesis search 7765 Auditory cortex interneuron development across human life history from childhood to requires cadherins operating hair-cell adolescence to adulthood mechanoelectrical transduction Alison Gopnik, Shaun O’Grady, Christopher G. Lucas, Thomas L. Griffiths, Adrienne Wente, Sophie Bridgers, Rosie Baptiste Libe´-Philippot, Vincent Michel, Jacques Boutet de Aboody, Hoki Fung, and Ronald E. Dahl Monvel, Se´bastien Le Gal, Typhaine Dupont, Paul Avan, Christine Me´tin, Nicolas Michalski, and Christine Petit 7900 How language shapes the cultural inheritance of categories ARTHUR M. SACKLER COLLOQUIUM ON EXTENSION OF Susan A. Gelman and Steven O. Roberts BIOLOGY THROUGH CULTURE 7908 Coevolution of cultural intelligence, extended life history, sociality, and brain size in primates INTRODUCTION Sally E. Street, Ana F. Navarrete, Simon M. Reader, 7775 The extension of biology through culture and Kevin N. Laland Andrew Whiten, Francisco J. Ayala, Marcus W. Feldman, 7915 The evolution of cognitive mechanisms in response to and Kevin N. Laland cultural innovations Arnon Lotem, Joseph Y. Halpern, Shimon Edelman, COLLOQUIUM PAPERS and Oren Kolodny 7782 Cultural evolutionary theory: How culture evolves and why it matters Nicole Creanza, Oren Kolodny, and Marcus W. Feldman PHYSICAL SCIENCES 7790 Culture extends the scope of evolutionary biology in the great apes BIOPHYSICS AND COMPUTATIONAL BIOLOGY Andrew Whiten E6097 Continuous immunotypes describe human immune variation and predict diverse responses 7798 Synchronized practice helps bearded capuchin Kevin J. Kaczorowski, Karthik Shekhar, Dieudonne´ monkeys learn to extend attention while Nkulikiyimfura, Cornelia L. Dekker, Holden Maecker, Mark M. learning a tradition Davis, Arup K. Chakraborty, and Petter Brodin Dorothy M. Fragaszy, Yonat Eshchar, Elisabetta Visalberghi, Briseida Resende, Kellie Laity, and Patrı´cia Izar CHEMISTRY 7806 Older, sociable capuchins (Cebus capucinus) invent 7923 Modeling adsorption properties of structurally more social behaviors, but younger monkeys – innovate more in other contexts deformed metal organic frameworks using structure–property map Susan E. Perry, Brendan J. Barrett, and Irene Godoy WooSeok Jeong, Dae-Woon Lim, Sungjune Kim, Aadesh 7814 Gene–culture coevolution in whales and dolphins Harale, Minyoung Yoon, Myunghyun Paik Suh, and Jihan Kim Hal Whitehead

7822 Song hybridization events during revolutionary song EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES change provide insights into cultural transmission in 7929 Mercury evidence for pulsed volcanism during the humpback whales end-Triassic mass extinction Ellen C. Garland, Luke Rendell, Luca Lamoni, M. Michael Poole, Lawrence M. E. Percival, Micha Ruhl, Stephen P. Hesselbo, and Michael J. Noad Hugh C. Jenkyns, Tamsin A. Mather, and Jessica H. Whiteside 7830 Conformity does not perpetuate suboptimal traditions 8047 Early Paleocene landbird supports rapid phylogenetic in a wild population of songbirds and morphological diversification of crown birds after Lucy M. Aplin, Ben C. Sheldon, and Richard McElreath the K–Pg mass extinction 7838 A social insect perspective on the evolution of social Daniel T. Ksepka, Thomas A. Stidham, learning mechanisms and Thomas E. Williamson Ellouise Leadbeater and Erika H. Dawson See Commentary on page 7750 7846 Cultural macroevolution matters Russell D. Gray and Joseph Watts ENGINEERING 7853 Pursuing Darwin’s curious parallel: Prospects for 7935 On the debris-level origins of adhesive wear a science of cultural evolution Ramin Aghababaei, Derek H. Warner, Alex Mesoudi and Jean-Franc¸ois Molinari

iv u www.pnas.org Contents Downloaded by guest on September 27, 2021 PHYSICS 7915 The evolution of cognitive mechanisms in response to 7941 Enhanced coupling of light into a turbid medium cultural innovations through microscopic interface engineering Arnon Lotem, Joseph Y. Halpern, Shimon Edelman, Jonathan V. Thompson, Brett H. Hokr, Wihan Kim, Charles W. and Oren Kolodny Ballmann, Brian E. Applegate, Javier Jo, Alexey Yamilov, Hui 7963 Harm to self outweighs benefit to others in moral Cao, Marlan O. Scully, and Vladislav V. Yakovlev decision making 7947 Entanglement and thermodynamics after a quantum Lukas J. Volz, B. Locke Welborn, Matthias S. Gobel, Michael S. quench in integrable systems Gazzaniga, and Scott T. Grafton Vincenzo Alba and Pasquale Calabrese 7969 Reduced orbitofrontal cortical volume is associated 7952 Probing large viscosities in glass-formers with with interdependent self-construal nonequilibrium simulations Shinobu Kitayama, Kuniaki Yanagisawa, Ayahito Ito, Ryuhei Vikram Jadhao and Mark O. Robbins Ueda, Yukiko Uchida, and Nobuhito Abe

BIOLOGICAL SCIENCES SOCIAL SCIENCES AGRICULTURAL SCIENCES ANTHROPOLOGY 7975 Light-mediated self-organization of sunflower stands 7782 Cultural evolutionary theory: How culture evolves and increases oil yield in the field why it matters Mo´nica Lo´pez Pereira, Victor O. Sadras, William Batista, Nicole Creanza, Oren Kolodny, and Marcus W. Feldman Jorge J. Casal, and Antonio J. Hall 7790 Culture extends the scope of evolutionary biology in the great apes ANTHROPOLOGY Andrew Whiten 7806 Older, sociable capuchins (Cebus capucinus) invent 7846 Cultural macroevolution matters more social behaviors, but younger monkeys Russell D. Gray and Joseph Watts innovate more in other contexts Susan E. Perry, Brendan J. Barrett, and Irene Godoy 7861 Evolutionary neuroscience of cumulative culture ’ Dietrich Stout and Erin E. Hecht 7853 Pursuing Darwin s curious parallel: Prospects for a science of cultural evolution 7869 Identifying early modern human ecological niche Alex Mesoudi expansions and associated cultural dynamics in the South African Middle Stone Age APPLIED BIOLOGICAL SCIENCES Francesco d’Errico, William E. Banks, Dan L. Warren, Giovanni Sgubin, Karen van Niekerk, Christopher Henshilwood, 7941 Enhanced coupling of light into a turbid medium Anne-Laure Daniau, and Marı´a Fernanda Sa´nchez Gon˜i through microscopic interface engineering Jonathan V. Thompson, Brett H. Hokr, Wihan Kim, Charles W. Ballmann, Brian E. Applegate, Javier Jo, Alexey Yamilov, Hui ECONOMIC SCIENCES Cao, Marlan O. Scully, and Vladislav V. Yakovlev 7958 Bayesian markets to elicit private information Aure´lien Baillon BIOCHEMISTRY E6034 Anti-inflammatory ω-3 endocannabinoid epoxides Daniel R. McDougle, Josephine E. Watson, Amr A. Abdeen, PSYCHOLOGICAL AND COGNITIVE SCIENCES Reheman Adili, Megan P. Caputo, John E. Krapf, Rodney W. E6192 Attention model of binocular rivalry Johnson, Kristopher A. Kilian, Michael Holinstat, and Aditi Das Hsin-Hung Li, James Rankin, John Rinzel, Marisa Carrasco, and David J. Heeger E6044 Structural insights into lipoprotein N-acylation by Escherichia coli apolipoprotein N-acyltransferase 7838 A social insect perspective on the evolution of social Cameron L. Noland, Michele D. Kattke, Jingyu Diao, Susan L. learning mechanisms Gloor, Homer Pantua, Mike Reichelt, Anand K. Katakam, Ellouise Leadbeater and Erika H. Dawson Donghong Yan, Jing Kang, Inna Zilberleyb, Min Xu, Sharookh B. 7853 Pursuing Darwin’s curious parallel: Prospects for Kapadia, and Jeremy M. Murray a science of cultural evolution E6054 G9a coordinates with the RPA complex to promote Alex Mesoudi DNA damage repair and cell survival 7877 Cumulative cultural learning: Development Qiaoyan Yang, Qian Zhu, Xiaopeng Lu, Yipeng Du, Linlin Cao, and diversity Changchun Shen, Tianyun Hou, Meiting Li, Zhiming Li, Chaohua Liu, Di Wu, Xingzhi Xu, Lina Wang, Haiying Wang, Ying Zhao, Cristine H. Legare Yang Yang, and Wei-Guo Zhu 7884 Young children communicate their ignorance and 7981 UCP1 deficiency causes brown fat respiratory chain ask questions depletion and sensitizes mitochondria to calcium Paul L. Harris, Deborah T. Bartz, and Meredith L. Rowe overload-induced dysfunction 7892 Changes in cognitive flexibility and hypothesis search Lawrence Kazak, Edward T. Chouchani, Irina G. Stavrovskaya, across human life history from childhood to Gina Z. Lu, Mark P. Jedrychowski, Daniel F. Egan, Manju Kumari, adolescence to adulthood Xingxing Kong, Brian K. Erickson, John Szpyt, Evan D. Rosen, Alison Gopnik, Shaun O’Grady, Christopher G. Lucas, Michael P. Murphy, Bruce S. Kristal, Steven P. Gygi, Thomas L. Griffiths, Adrienne Wente, Sophie Bridgers, Rosie and Bruce M. Spiegelman Aboody, Hoki Fung, and Ronald E. Dahl See Commentary on page 7744 7900 How language shapes the cultural inheritance 7987 Stable membrane orientations of small dual-topology of categories membrane proteins Susan A. Gelman and Steven O. Roberts Nir Fluman, Victor Tobiasson, and Gunnar von Heijne

Contents PNAS u July 25, 2017 u vol. 114 u no. 30 u v Downloaded by guest on September 27, 2021 7993 MmpL3 is the flippase for mycolic acids 7869 Identifying early modern human ecological niche in mycobacteria expansions and associated cultural dynamics in Zhujun Xu, Vladimir A. Meshcheryakov, Giovanna Poce, the South African Middle Stone Age and Shu-Sin Chng Francesco d’Errico, William E. Banks, Dan L. Warren, Giovanni 7999 mTORC1 activates SREBP-2 by suppressing Sgubin, Karen van Niekerk, Christopher Henshilwood, cholesterol trafficking to lysosomes in mammalian cells Anne-Laure Daniau, and Marı´a Fernanda Sa´nchez Gon˜i Walaa Eid, Kristin Dauner, Kevin C. Courtney, AnneMarie 8035 Behavioral self-organization underlies the resilience of Gagnon, Robin J. Parks, Alexander Sorisky, and Xiaohui Zha a coastal ecosystem He´le`ne de Paoli, Tjisse van der Heide, Aniek van den Berg, BIOPHYSICS AND COMPUTATIONAL BIOLOGY Brian R. Silliman, Peter M. J. Herman, and Johan van de Koppel E6064 Size and mobility of lipid domains tuned by See Commentary on page 7747 geometrical constraints Ole M. Schu¨tte, Ingo Mey, Jo¨rg Enderlein, Filip Savic, Burkhard Geil, Andreas Janshoff, and Claudia Steinem ENVIRONMENTAL SCIENCES 8005 Monomeric and fibrillar α-synuclein exert opposite 8041 Interannual cycles of Hantaan virus outbreaks at the – effects on the catalytic cycle that promotes the human animal interface in Central China are proliferation of Aβ42 aggregates controlled by temperature and rainfall Sean Chia, Patrick Flagmeier, Johnny Habchi, Veronica Lattanzi, Huaiyu Tian, Pengbo Yu, Bernard Cazelles, Lei Xu, Hua Tan, Jing Sara Linse, Christopher M. Dobson, Tuomas P. J. Knowles, Yang, Shanqian Huang, Bo Xu, Jun Cai, Chaofeng Ma, Jing Wei, and Michele Vendruscolo Shen Li, Jianhui Qu, Marko Laine, Jingjun Wang, Shilu Tong, Nils Chr. Stenseth, and Bing Xu 8011 Crystal structure of CO-bound cytochrome c oxidase determined by serial femtosecond X-ray crystallography at room temperature EVOLUTION Izumi Ishigami, Nadia A. Zatsepin, Masahide Hikita, Chelsie E. 7782 Cultural evolutionary theory: How culture evolves and Conrad, Garrett Nelson, Jesse D. Coe, Shibom Basu, Thomas D. why it matters Grant, Matthew H. Seaberg, Raymond G. Sierra, Mark S. Hunter, Nicole Creanza, Oren Kolodny, and Marcus W. Feldman Petra Fromme, Raimund Fromme, Syun-Ru Yeh, and Denis L. Rousseau 7790 Culture extends the scope of evolutionary biology in 8017 Antibody-induced uncoating of human rhinovirus B14 the great apes Yangchao Dong, Yue Liu, Wen Jiang, Thomas J. Smith, Zhikai Andrew Whiten Xu, and Michael G. Rossmann 7814 Gene–culture coevolution in whales and dolphins 8023 Otoferlin is a multivalent calcium-sensitive scaffold Hal Whitehead linking SNAREs and calcium channels 7838 A social insect perspective on the evolution of social Nicole Hams, Murugesh Padmanarayana, Weihong Qiu, learning mechanisms and Colin P. Johnson Ellouise Leadbeater and Erika H. Dawson

CELL BIOLOGY 7846 Cultural macroevolution matters Russell D. Gray and Joseph Watts E6072 Functional characterization of human pluripotent stem cell-derived arterial endothelial cells 7908 Coevolution of cultural intelligence, extended life Jue Zhang, Li-Fang Chu, Zhonggang Hou, Michael P. Schwartz, history, sociality, and brain size in primates Timothy Hacker, Vernella Vickerman, Scott Swanson, Ning Leng, Sally E. Street, Ana F. Navarrete, Simon M. Reader, Bao Kim Nguyen, Angela Elwell, Jennifer Bolin, Matthew E. and Kevin N. Laland Brown, Ron Stewart, William J. Burlingham, William L. Murphy, 7915 The evolution of cognitive mechanisms in response to and James A. Thomson cultural innovations 2+ E6079 TRPM7 senses oxidative stress to release Zn from Arnon Lotem, Joseph Y. Halpern, Shimon Edelman, unique intracellular vesicles and Oren Kolodny Sunday A. Abiria, Grigory Krapivinsky, Rajan Sah, Ana G. 8047 Early Paleocene landbird supports rapid phylogenetic Santa-Cruz, Dipayan Chaudhuri, Jin Zhang, Pichet and morphological diversification of crown birds after Adstamongkonkul, Paul G. DeCaen, and David E. Clapham the K–Pg mass extinction DEVELOPMENTAL BIOLOGY Daniel T. Ksepka, Thomas A. Stidham, and Thomas E. Williamson 8029 Deletion of Gas2l3 in mice leads to specific defects in See Commentary on page 7750 cardiomyocyte cytokinesis during development Sabine Stopp, Marco Gru¨ndl, Marc Fackler, Jonas Malkmus, 8053 Haploid selection within a single ejaculate increases Marina Leone, Ronald Naumann, Stefan Frantz, Elmar Wolf, offspring fitness Bjo¨rn von Eyss, Felix B. Engel, and Stefan Gaubatz Ghazal Alavioon, Cosima Hotzy, Khriezhanuo Nakhro, Sandra Rudolf, Douglas G. Scofield, Susanne Zajitschek, Alexei A. ECOLOGY Maklakov, and Simone Immler E6089 Biological annihilation via the ongoing sixth mass extinction signaled by vertebrate population GENETICS losses and declines Gerardo Ceballos, Paul R. Ehrlich, and Rodolfo Dirzo 8059 Fast and accurate HLA typing from short-read next-generation sequence data with xHLA 7822 Song hybridization events during revolutionary song Chao Xie, Zhen Xuan Yeo, Marie Wong, Jason Piper, Tao Long, change provide insights into cultural transmission in Ewen F. Kirkness, William H. Biggs, Ken Bloom, Stephen humpback whales Spellman, Cynthia Vierra-Green, Colleen Brady, Richard H. Ellen C. Garland, Luke Rendell, Luca Lamoni, M. Michael Poole, Scheuermann, Amalio Telenti, Sally Howard, Suzanne and Michael J. Noad Brewerton, Yaron Turpaz, and J. Craig Venter

vi u www.pnas.org Contents Downloaded by guest on September 27, 2021 IMMUNOLOGY AND INFLAMMATION MICROBIOLOGY E6097 Continuous immunotypes describe human immune E6176 Two dynamin-like proteins stabilize FtsZ rings during variation and predict diverse responses Streptomyces sporulation Kevin J. Kaczorowski, Karthik Shekhar, Dieudonne´ Susan Schlimpert, Sebastian Wasserstrom, Govind Chandra, Nkulikiyimfura, Cornelia L. Dekker, Holden Maecker, Mark M. Maureen J. Bibb, Kim C. Findlay, Klas Fla¨rdh, Davis, Arup K. Chakraborty, and Petter Brodin and Mark J. Buttner E6107 Influenza infection triggers disease in a genetic model E6184 Bifunctionality of a biofilm matrix protein controlled of experimental autoimmune encephalomyelitis by redox state Stephen Blackmore, Jessica Hernandez, Michal Juda, Emily Sofia Arnaouteli, Ana Sofia Ferreira, Marieke Schor, Ryan J. Ryder, Gregory G. Freund, Rodney W. Johnson, Morris, Keith M. Bromley, Jeanyoung Jo, Krista L. Cortez, and Andrew J. Steelman Tetyana Sukhodub, Alan R. Prescott, Lars E. P. Dietrich, Cait E. E6117 Suboptimal T-cell receptor signaling compromises MacPhee, and Nicola R. Stanley-Wall protein translation, ribosome biogenesis, and 8077 Polar delivery of Legionella type IV secretion system proliferation of mouse CD8 T cells substrates is essential for virulence Thomas C. J. Tan, John Knight, Thomas Sbarrato, Kate Dudek, Kwangcheol C. Jeong, Debnath Ghosal, Yi-Wei Chang, Grant J. Anne E. Willis, and Rose Zamoyska Jensen, and Joseph P. Vogel

MEDICAL SCIENCES NEUROSCIENCE E6127 Loss-of-function mutation in Mirta22/Emc10 rescues specific schizophrenia-related phenotypes in E6192 Attention model of binocular rivalry a mouse model of the 22q11.2 deletion Hsin-Hung Li, James Rankin, John Rinzel, Marisa Carrasco, and David J. Heeger Anastasia Diamantopoulou, Ziyi Sun, Jun Mukai, Bin Xu, Karine Fenelon, Maria Karayiorgou, and Joseph A. Gogos E6202 Acetylcholine-producing NK cells attenuate CNS E6137 Combined epigenetic and differentiation-based inflammation via modulation of treatment inhibits neuroblastoma tumor growth infiltrating monocytes/macrophages and links HIF2α to tumor suppression Wei Jiang, Daojing Li, Ranran Han, Chao Zhang, Wei-Na Jin, Kristofer Wood, Qiang Liu, Fu-Dong Shi, Isabelle Westerlund, Yao Shi, Konstantinos Toskas, and Junwei Hao Stuart M. Fell, Shuijie Li, Olga Surova, Erik So¨dersten, Per Kogner, Ulrika Nyman, Susanne Schlisio, E6212 Synaptic properties of the lemniscal and paralemniscal and Johan Holmberg pathways to the mouse somatosensory thalamus E6147 Multiplexed RNAi therapy against brain Christina Mo, Iraklis Petrof, Angela N. Viaene, tumor-initiating cells via lipopolymeric nanoparticle and S. Murray Sherman infusion delays glioblastoma progression E6222 Corticogeniculate feedback sharpens the temporal Dou Yu, Omar F. Khan, Mario L. Suva`, Biqin Dong, precision and spatial resolution of visual signals in Wojciech K. Panek, Ting Xiao, Meijing Wu, Yu Han, the ferret Atique U. Ahmed, Irina V. Balyasnikova, Hao F. Zhang, J. Michael Hasse and Farran Briggs Cheng Sun, Robert Langer, Daniel G. Anderson, and Maciej S. Lesniak 7765 Auditory cortex interneuron development requires cadherins operating hair-cell E6157 Stem cell-released oncolytic herpes simplex mechanoelectrical transduction virus has therapeutic efficacy in brain Baptiste Libe´-Philippot, Vincent Michel, Jacques Boutet de metastatic melanomas Monvel, Se´bastien Le Gal, Typhaine Dupont, Paul Avan, Wanlu Du, Ivan Seah, Oumaima Bougazzoul, GiHun Choi, Christine Me´tin, Nicolas Michalski, and Christine Petit Katrina Meeth, Marcus W. Bosenberg, Hiroaki Wakimoto, David Fisher, and Khalid Shah 7861 Evolutionary neuroscience of cumulative culture Dietrich Stout and Erin E. Hecht E6166 Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children 8083 Frequency-specific directed interactions in the human Guoyan Zhao, Tommi Vatanen, Lindsay Droit, Arnold brain network for language Park, Aleksandar D. Kostic, Tiffany W. Poon, Hera Vlamakis, Jan-Mathijs Schoffelen, Annika Hulte´n, Nietzsche Lam, Andre´F. Heli Siljander, Taina Ha¨rko¨nen, Anu-Maaria Ha¨ma¨la¨inen, Marquand, Julia Udde´n, and Peter Hagoort Aleksandr Peet, Vallo Tillmann, Jorma Ilonen, David 8089 Acute inflammation regulates neuroregeneration Wang, Mikael Knip, Ramnik J. Xavier, through the NF-κB pathway in olfactory epithelium and Herbert W. Virgin Mengfei Chen, Randall R. Reed, and Andrew P. Lane 8065 BMTP-11 is active in preclinical models of human 8095 Genetic identification of a hindbrain nucleus essential osteosarcoma and a candidate targeted drug for innate vocalization for clinical translation Luis Rodrigo Hernandez-Miranda, Pierre-Louis Ruffault, Julien C. Valerae O. Lewis, Eswaran Devarajan, Marina Bouvier, Andrew J. Murray, Marie-Pierre Morin-Surun, Niccolo` Cardo´-Vila, Dafydd G. Thomas, Eugenie S. Kleinerman, Zampieri, Justyna B. Cholewa-Waclaw, Elodie Ey, Serena Marchio`, Richard L. Sidman, Renata Pasqualini, Jean-Francois Brunet, Jean Champagnat, Gilles Fortin, and Wadih Arap and Carmen Birchmeier 8071 tsRNA signatures in cancer Veronica Balatti, Giovanni Nigita, Dario Veneziano, Alessandra PHARMACOLOGY Drusco, Gary S. Stein, Terri L. Messier, Nicholas H. Farina, Jane B. Lian, Luisa Tomasello, Chang-gong Liu, Alexey E6231 Prediction of intracellular exposure bridges the gap Palamarchuk, Jonathan R. Hart, Catherine Bell, Mariantonia between target- and cell-based drug discovery Carosi, Edoardo Pescarmona, Letizia Perracchio, Maria Diodoro, Andre´ Mateus, Laurie J. Gordon, Gareth J. Wayne, Helena Andrea Russo, Anna Antenucci, Paolo Visca, Antonio Ciardi, Almqvist, Hanna Axelsson, Brinton Seashore-Ludlow, Andrea Curtis C. Harris, Peter K. Vogt, Yuri Pekarsky, Treyer, Pa¨r Matsson, Thomas Lundba¨ck, Andy West, and Carlo M. Croce Michael M. Hann, and Per Artursson

Contents PNAS u July 25, 2017 u vol. 114 u no. 30 u vii Downloaded by guest on September 27, 2021 E6240 Analyses of PDE-regulated phosphoproteomes reveal 8113 NLR network mediates immunity to diverse unique and specific cAMP-signaling modules in T cells plant pathogens Michael-Claude G. Beltejar, Ho-Tak Lau, Martin G. Golkowski, Chih-Hang Wu, Ahmed Abd-El-Haliem, Tolga O. Bozkurt, Shao-En Ong, and Joseph A. Beavo Khaoula Belhaj, Ryohei Terauchi, Jack H. Vossen, See Commentary on page 7741 and Sophien Kamoun

PHYSIOLOGY PSYCHOLOGICAL AND COGNITIVE SCIENCES E6250 Loss of mouse cardiomyocyte talin-1 and talin-2 leads 7798 Synchronized practice helps bearded capuchin to β-1 integrin reduction, costameric instability, and monkeys learn to extend attention while dilated cardiomyopathy learning a tradition Ana Maria Manso, Hideshi Okada, Francesca M. Sakamoto, Dorothy M. Fragaszy, Yonat Eshchar, Elisabetta Visalberghi, Emily Moreno, Susan J. Monkley, Ruixia Li, David R. Critchley, Briseida Resende, Kellie Laity, and Patrı´cia Izar and Robert S. Ross 7830 Conformity does not perpetuate suboptimal traditions E6260 Caffeine induces gastric acid secretion via bitter taste in a wild population of songbirds signaling in gastric parietal cells Lucy M. Aplin, Ben C. Sheldon, and Richard McElreath Kathrin Ingrid Liszt, Jakob Peter Ley, Barbara Lieder, Maik 8119 Intranasal oxytocin treatment for social deficits and Behrens, Verena Sto¨ger, Angelika Reiner, Christina Maria biomarkers of response in children with autism Hochkogler, Elke Ko¨ck, Alessandro Marchiori, Joachim Hans, Karen J. Parker, Ozge Oztan, Robin A. Libove, Raena D. Sabine Widder, Gerhard Krammer, Gareth John Sanger, Mark Sumiyoshi, Lisa P. Jackson, Debra S. Karhson, Jacqueline E. Manuel Somoza, Wolfgang Meyerhof, and Veronika Somoza Summers, Kyle E. Hinman, Kara S. Motonaga, Jennifer M. Phillips, Dean S. Carson, Joseph P. Garner, PLANT BIOLOGY and Antonio Y. Hardan 8101 Genomic architecture of biomass heterosis in Arabidopsis Mei Yang, Xuncheng Wang, Diqiu Ren, Hao Huang, Miqi Xu, CORRECTION (ONLINE ONLY) Guangming He, and Xing Wang Deng MEDICAL SCIENCES 8107 Structure of the Arabidopsis TOPLESS corepressor E6270 Targeting reactive nitrogen species suppresses provides insight into the evolution of hereditary pancreatic cancer transcriptional repression Mo Li, Qian Chen, Teng Ma, and Xiaochun Yu Raquel Martin-Arevalillo, Max H. Nanao, Antoine Larrieu, Thomas Vinos-Poyo, David Mast, Carlos Galvan-Ampudia, Ge´raldine Brunoud, Teva Vernoux, Renaud Dumas, and Franc¸ois Parcy ix Subscription Form

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