CANADIAN PATENTEES and PATENTED DRUG PRODUCTS for HUMAN USE JANUARY 1 – DECEMBER 31, 2007 DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status

PMPRB ANNUAL REPORT 2007

CANADIAN PATENTEES AND PATENTED DRUG PRODUCTS FOR HUMAN USE JANUARY 1 – DECEMBER 31, 2007 DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status

3M PHARMACEUTICALS, 3M CANADA INC. 02186829 DISALCID - 500MG/TAB salsalate N02BA tablet not sold No Current Sales 02186837 DISALCID - 750MG/TAB salsalate N02BA tablet not sold No Current Sales

ABBOTT LABORATORIES LIMITED 02146908 BIAXIN - 25MG/ML clarithromycin J01FA powder for oral suspension Within Guidelines 02244641 BIAXIN - 50MG/ML clarithromycin J01FA powder for oral suspension Within Guidelines 01984853 BIAXIN - 250MG/TAB clarithromycin J01FA tablet Within Guidelines 02126710 BIAXIN - 500MG/TAB clarithromycin J01FA tablet Within Guidelines 02244756 BIAXIN XL - 500MG/TAB clarithromycin J01FA extended-release tablet Within Guidelines 02242736 EPIVAL ER - 500MG/TAB divalproex sodium N03AG extended-release tablet not sold No Current Sales 02248968 FACTIVE - 320MG/TAB gemifloxacin mesylate J01MA tablet introduced (nas) Within Guidelines 02238525 HP-PAC 30/500/500 lansoprazole/clarithromycin/amoxicillin A02BD oral kit Within Guidelines 02258595 HUMIRA - 40MG/SYRINGE adalimumab L04AA injectable solution Within Guidelines 02242163 KADIAN - 10MG/CAP morphine sulfate N02AA sustained-release capsule Within Guidelines 02184435 KADIAN - 20MG/CAP morphine sulfate N02AA sustained-release capsule Within Guidelines 02184443 KADIAN - 50MG/CAP morphine sulfate N02AA sustained-release capsule Within Guidelines 02184451 KADIAN - 100MG/CAP morphine sulfate N02AA sustained-release capsule Within Guidelines 02243643 KALETRA 133.3/33.3 lopinavir/ritonavir J05AE capsule Within Guidelines 02285533 KALETRA 200/50 lopinavir/ritonavir J05AE tablet Within Guidelines 02243644 KALETRA 80/20 lopinavir/ritonavir J05AE oral solution Within Guidelines 02239834 LUPRON DEPOT - 11.25MG/VIAL leuprolide acetate L02AE powder for injectable solution Within Guidelines 02230248 LUPRON DEPOT - 22.5MG/VIAL leuprolide acetate L02AE powder for injectable solution Within Guidelines 02239833 LUPRON DEPOT - 30MG/VIAL leuprolide acetate L02AE powder for injectable solution Within Guidelines 02231457 MAVIK - 0.5MG/CAP trandolapril C09AA capsule Subj. Investigation 02231459 MAVIK - 1MG/CAP trandolapril C09AA capsule Within Guidelines 02231460 MAVIK - 2MG/CAP trandolapril C09AA capsule Within Guidelines 02239267 MAVIK - 4MG/CAP trandolapril C09AA capsule Within Guidelines 02243163 MERIDIA - 10MG/CAP sibutramine hydrochloride A08AA capsule Subj. Investigation 02243164 MERIDIA - 15MG/CAP sibutramine hydrochloride A08AA capsule Within Guidelines 02087308 MIVACRON - 2MG/ML mivacurium chloride M03AC injectable solution expired No Current Sales 02229422 NIMBEX - 2MG/ML cisatracurium besylate M03AC injectable solution Within Guidelines 02229423 NIMBEX - 10MG/ML cisatracurium besylate M03AC injectable solution not sold No current sales 02229137 NORVIR - 100MG/CAP ritonavir J05AE capsule not sold No current sales 02229145 NORVIR - 80MG/ML ritonavir J05AE oral solution Within Guidelines 02241480 NORVIR SEC - 100MG/CAP ritonavir J05AE capsule Within Guidelines 00769991 PCE DISPERTAB - 333MG/TAB erythromycin J01FA tablet Within Guidelines 02165503 PREVACID - 15MG/CAP lansoprazole A02BC sustained-release capsule Within Guidelines 02165511 PREVACID - 30MG/CAP lansoprazole A02BC sustained-release capsule Within Guidelines 02258609 PREVACID - 15MG/DOSE lansoprazole A02BC delayed-release oral granules not sold No Current Sales

02258617 PREVACID - 30MG/DOSE lansoprazole A02BC delayed-release oral granules not sold No Current Sales www.pmprb-cepmb.gc.ca January 1 — December 31, 2007 Annual Report 2007 1 DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status ABBOTT LABORATORIES LIMITED (continued) 02249464 PREVACID FASTAB - 15MG/TAB lansoprazole A02BC orally disintegrating tablet introduced Within Guidelines 02249472 PREVACID FASTAB - 30MG/TAB lansoprazole A02BC orally disintegrating tablet Within Guidelines 02258080 PREVACID I.V. - 30MG/VIAL lansoprazole sodium A02BC powder for injectable solution not sold No Current Sales 02251485 RYTHMOL SR - 225MG/CAP propafenone hydrochloride C01BC extended-release capsule not sold No Current Sales 02251493 RYTHMOL SR - 325MG/CAP propafenone hydrochloride C01BC extended-release capsule not sold No Current Sales 02251507 RYTHMOL SR - 425MG/CAP propafenone hydrochloride C01BC extended-release capsule not sold No Current Sales 02172763 SEVORANE sevoflurane N01AB inhalation anesthetic Within Guidelines 02245889 SYNAGIS - 50MG/VIAL palivizumab J06BB powder for injectable solution Within Guidelines 02245890 SYNAGIS - 100MG/VIAL palivizumab J06BB powder for injectable solution Within Guidelines 02238095 TARKA 1/180 trandolapril/verapamil hydrochloride C09BB sustained-release tablet not sold No Current Sales 02240945 TARKA 1/240 trandolapril/verapamil hydrochloride C09BB sustained-release tablet Within Guidelines 02238096 TARKA 2/180 trandolapril/verapamil hydrochloride C09BB sustained-release tablet Within Guidelines 02240946 TARKA 2/240 trandolapril/verapamil hydrochloride C09BB sustained-release tablet Within Guidelines 02238097 TARKA 4/240 trandolapril/verapamil hydrochloride C09BB sustained-release tablet Within Guidelines 02230409 ULTIVA - 1MG/VIAL remifentanil hydrochloride N01AH powder for injectable solution Within Guidelines 02230410 ULTIVA - 2MG/VIAL remifentanil hydrochloride N01AH powder for injectable solution Within Guidelines 02230411 ULTIVA - 5MG/VIAL remifentanil hydrochloride N01AH powder for injectable solution not sold No Current Sales 02242018 VICOPROFEN 7.5/200 hydrocodone bitartrate/ibuprofen M01AE tablet expired No Current Sales 02266202 ZEMPLAR - 5MCG/ML paricalcitol A11CC injectable solution VCU

ABRAXIS ONCOLOGY 02281066 ABRAXANE - 100MG/VIAL paclitaxel L01CD powder for injectable solution introduced Subj. Investigation

ACTELION PHARMACEUTICALS CANADA INC. 02244981 TRACLEER - 62.5MG/TAB bosentan C02KX tablet Within Guidelines 02244982 TRACLEER - 125MG/TAB bosentan C02KX tablet Within Guidelines 02250519 ZAVESCA - 100MG/CAP miglustat A16AX capsule Within Guidelines

ALCON CANADA INC. 02238873 AZOPT - 10MG/ML brinzolamide S01EC ophthalmic suspension Within Guidelines 01908448 BETOPTIC S - 2.5MG/ML betaxolol hydrochloride S01ED ophthalmic suspension Within Guidelines 02200864 CILOXAN - 3MG/G ciprofloxacin hydrochloride S01AX ophthalmic ointment Within Guidelines 01945270 CILOXAN - 3MG/ML ciprofloxacin hydrochloride S01AX ophthalmic solution Within Guidelines 02240035 CIPRO HC 2/10 ciprofloxacin hydrochloride/hydrocortisone S02CA otic suspension Within Guidelines 02252716 CIPRODEX 3/1 ciprofloxacin hydrochloride/dexamethasone S02CA otic suspension introduced Subj. Investigation 02278251 DUO TRAV .04/5 travoprost/timolol maleate S01ED ophthalmic solution Within Guidelines 02237355 EMADINE - 0.5MG/ML emedastine difumarate S01GX ophthalmic solution Within Guidelines 02233143 PATANOL - 1MG/ML olopatadine hydrochloride S01GX ophthalmic solution Within Guidelines 02248967 SYSTANE 0.4%/0.3% polyethylene glycol/propylene glycol S01XA ophthalmic drops Within Guidelines 00778915 TOBRADEX 3/1 tobramycin/dexamethasone S01CA ophthalmic ointment Within Guidelines 00778907 TOBRADEX 3/1 tobramycin/dexamethasone S01CA ophthalmic suspension Within Guidelines 02244896 TRAVATAN - 0.04MG/ML travoprost S01EE ophthalmic solution Within Guidelines 02163691 VEXOL - 10MG/ML rimexolone S01BA ophthalmic suspension Within Guidelines 02252260 VIGAMOX - 5MG/ML moxifloxacin hydrochloride S01AX ophthalmic solution Within Guidelines

ALLERGAN INC. 01968300 ACULAR - 5MG/ML ketorolac tromethamine S01BC ophthalmic solution Within Guidelines 02248722 ACULAR LS - 4MG/ML ketorolac tromethamine S01BC ophthalmic solution Within Guidelines 02241407 ALOCRIL - 20MG/ML nedocromil sodium S01GX ophthalmic drops expired Within Guidelines 02236876 ALPHAGAN - 2MG/ML brimonidine tartrate S01EA ophthalmic solution Within Guidelines 02236877 ALPHAGAN - 5MG/ML brimonidine tartrate S01EA ophthalmic solution not sold No Current Sales

www.pmprb-cepmb.gc.ca 02248151 ALPHAGAN P - 1.5MG/ML brimonidine tartrate S01EA ophthalmic solution Wtihin Guidelines

2 Canadian Patentees and Patented Drug Products for Human Use DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status ALLERGAN INC. (continued) 01981501 BOTOX - 100UNIT/VIAL botulinum toxin type A M03AX powder for injectable solution Within Guidelines 02243721 BOTOX COSMETIC - 100UNIT/VIAL botulinum toxin type A M03AX powder for injectable solution Within Guidelines 02248347 COMBIGAN 2/5 brimonidine tartrate/timolol maleate S01ED ophthalmic solution Within Guidelines 02245860 LUMIGAN - 0.3MG/ML bimatoprost S01EE ophthalmic solution Within Guidelines 02230784 TAZORAC - 0.5MG/G tazarotene D05AX gel Within Guidelines 02243894 TAZORAC - 0.5MG/G tazarotene D05AX topical cream Within Guidelines 02230785 TAZORAC - 1MG/G tazarotene D05AX gel Within Guidelines 02243895 TAZORAC - 1MG/G tazarotene D05AX topical cream Within Guidelines 02257270 ZYMAR - 3MG/ML gatifloxacin S01AX ophthalmic solution Within Guidelines

AMGEN CANADA INC. 02246344 ARANESP HSA - 15MCG/ML darbepoetin alfa B03XA injectable solution not sold No Current Sales 02246347 ARANESP HSA - 40MCG/ML darbepoetin alfa B03XA injectable solution not sold No Current Sales 02246348 ARANESP HSA - 60MCG/ML darbepoetin alfa B03XA injectable solution not sold No Current Sales 02246349 ARANESP HSA - 100MCG/ML darbepoetin alfa B03XA injectable solution not sold No Current Sales 02246350 ARANESP HSA - 200MCG/ML darbepoetin alfa B03XA injectable solution not sold No Current Sales 02246351 ARANESP HSA - 325MCG/ML darbepoetin alfa B03XA injectable solution not sold No Current Sales 02246352 ARANESP HSA - 500MCG/ML darbepoetin alfa B03XA injectable solution not sold No Current Sales 02246345 ARANESP HSA - 25MCG/ML darbepoetin alfa B03XA injectable solution not sold No Current Sales 02246353 ARANESP HSA FREE - 15MCG/ML darbepoetin alfa B03XA injectable solution not sold No Current Sales 02246354 ARANESP HSA FREE - 25MCG/ML darbepoetin alfa B03XA injectable solution Within Guidelines 02246355 ARANESP HSA FREE - 40MCG/ML darbepoetin alfa B03XA injectable solution Within Guidelines 02246356 ARANESP HSA FREE - 60MCG/ML darbepoetin alfa B03XA injectable solution not sold No Current Sales 02246357 ARANESP HSA FREE - 100MCG/ML darbepoetin alfa B03XA injectable solution Within Guidelines 02246358 ARANESP HSA FREE - 200MCG/ML darbepoetin alfa B03XA injectable solution Within Guidelines 02246359 ARANESP HSA FREE - 325MCG/ML darbepoetin alfa B03XA injectable solution not sold No Current Sales 02246360 ARANESP HSA FREE - 500MCG/ML darbepoetin alfa B03XA injectable solution Within Guidelines 02274728 ENBREL - 50MG/SYRINGE etanercept L04AA injectable solution Within Guidelines 02242903 ENBREL - 25MG/VIAL etanercept L04AA powder for injectable solution Within Guidelines 02274221 KEPIVANCE - 6.25MG/VIAL palifermin V03AF powder for injectable solution not sold No Current Sales 02245913 KINERET - 100MG/SYRINGE anakinra L04AA injectable solution Within Guidelines 02249790 NEULASTA - 10MG/ML pegfilgrastim L03AA injectable solution Subj. Investigation 01968017 NEUPOGEN - 0.3MG/ML filgrastim L03AA injectable solution Within Guidelines 02257130 SENSIPAR - 30MG/TAB cinacalcet hydrochloride H05BX tablet Within Guidelines 02257149 SENSIPAR - 60MG/TAB cinacalcet hydrochloride H05BX tablet Within Guidelines 02257157 SENSIPAR - 90MG/TAB cinacalcet hydrochloride H05BX tablet Within Guidelines 02240229 STEMGEN - 1.875MG/VIAL ancestim L03AA powder for injectable solution Within Guidelines 02240231 STEMGEN - 2.5MG/VIAL ancestim L03AA powder for injectable solution not sold No Current Sales

APOTEX INC. 02245669 APO-SALVENT CFC FREE - 0.1MG/DOSE salbutamol sulfate R03AC aerosol for inhalation Subj. Investigation

ASTELLAS PHARMA CANADA INC. 02139294 ADENOSCAN - 3MG/ML adenosine C01EB injectable solution Within Guidelines 02296462 ADVAGRAF - 0.5MG/CAP tacrolimus L04AA extended-release capsule not sold No Current Sales 02296470 ADVAGRAF - 1MG/CAP tacrolimus L04AA extended-release capsule not sold No Current Sales 02296489 ADVAGRAF - 5MG/CAP tacrolimus L04AA extended-release capsule not sold No Current Sales 02241630 AMBISOME - 50MG/VIAL amphotericin B J02AA powder for injectable solution Within Guidelines 02258986 AMEVIVE - 7.5MG/VIAL alefacept L04AA powder for injectable solution not sold No Current Sales 02259052 AMEVIVE - 15MG/VIAL alefacept L04AA powder for injectable solution Subj. Investigation 02294214 MYCAMINE - 25MG/VIAL micafungin sodium J02AX powder for injectable solution not sold No Current Sales www.pmprb-cepmb.gc.ca

January 1 — December 31, 2007 Annual Report 2007 3 DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status ASTELLAS PHARMA CANADA INC. (continued) 02294222 MYCAMINE - 50MG/VIAL micafungin sodium J02AX powder for injectable solution introduced (nas) Within Guidelines 02243144 PROGRAF - 0.5MG/CAP tacrolimus L04AA capsule Within Guidelines 02175991 PROGRAF - 1MG/CAP tacrolimus L04AA capsule Within Guidelines 02175983 PROGRAF - 5MG/CAP tacrolimus L04AA capsule Within Guidelines 02176009 PROGRAF - 5MG/ML tacrolimus L04AA injectable solution Within Guidelines 02244149 PROTOPIC - 0.3MG/G tacrolimus D11AX topical ointment Within Guidelines 02244148 PROTOPIC - 1MG/G tacrolimus D11AX topical ointment Within Guidelines 02277263 VESICARE - 5MG/TAB solifenacin succinate G04BD tablet Within Guidelines 02277271 VESICARE - 10MG/TAB solifenacin succinate G04BD tablet Within Guidelines

ASTRAZENECA CANADA INC. 02236606 ACCOLATE - 20MG/TAB zafirlukast R03DC tablet Within Guidelines 02224135 ARIMIDEX - 1MG/TAB anastrozole L02BG tablet Within Guidelines 02239090 ATACAND - 4MG/TAB candesartan cilexetil C09CA tablet Within Guidelines 02239091 ATACAND - 8MG/TAB candesartan cilexetil C09CA tablet Within Guidelines 02239092 ATACAND - 16MG/TAB candesartan cilexetil C09CA tablet Within Guidelines 02244021 ATACAND PLUS 16/12.5 candesartan cilexetil/hydrochlorothiazide C09DA tablet Within Guidelines 02028727 BETALOC CR - 47.5MG/TAB metoprolol succinate C07AB extended-release tablet not sold No Current Sales 02028735 BETALOC CR - 95MG/TAB metoprolol succinate C07AB extended-release tablet not sold No Current Sales 02028743 BETALOC CR - 190MG/TAB metoprolol succinate C07AB extended-release tablet not sold No Current Sales 00786616 BRICANYL TURBUHALER - 0.5MG/DOSE terbutaline sulfate R03AC powder for inhalation expired Within Guidelines 02265540 CRESTOR - 5MG/TAB rosuvastatin calcium C10AA tablet Within Guidelines 02247162 CRESTOR - 10MG/TAB rosuvastatin calcium C10AA tablet Within Guidelines 02247163 CRESTOR - 20MG/TAB rosuvastatin calcium C10AA tablet Within Guidelines 02247164 CRESTOR - 40MG/TAB rosuvastatin calcium C10AA tablet Within Guidelines 02018950 DIPRIVAN - 10MG/ML propofol N01AX injectable solution Within Guidelines 02057794 EMLA 25/25 lidocaine/prilocaine D04AB transdermal patch Within Guidelines 02229293 ENTOCORT - 3MG/CAP budesonide A07EA sustained-release capsule Within Guidelines 02052431 ENTOCORT - 0.02MG/ML budesonide A07EA enema Within Guidelines 02248624 FASLODEX - 250MG/SYRINGE fulvestrant L02BA injectable solution Subj. Investigation 02134810 FOSCAVIR - 24MG/ML foscarnet sodium J05AD injectable solution not sold No Current Sales 02248676 IRESSA - 250MG/TAB gefitinib L01XX tablet Within Guidelines 02238139 LOGIMAX 5/47.5 felodipine/metoprolol succinate C07FB sustained-release tablet not sold No Current Sales 02119579 LOSEC - 10MG/CAP omeprazole A02BC capsule Within Guidelines 00846503 LOSEC - 20MG/CAP omeprazole A02BC capsule Within Guidelines 02016788 LOSEC - 40MG/CAP omeprazole A02BC capsule Within Guidelines 02230737 LOSEC - 10MG/TAB omeprazole magnesium A02BC sustained-release tablet Within Guidelines 02190915 LOSEC - 20MG/TAB omeprazole magnesium A02BC sustained-release tablet Within Guidelines 02238391 LOSEC - 40MG/TAB omeprazole magnesium A02BC sustained-release tablet not sold No Current Sales 02242461 LOSEC MUPS - 10MG/TAB omeprazole magnesium A02BC sustained-release tablet Within Guidelines 02242462 LOSEC MUPS - 20MG/TAB omeprazole magnesium A02BC sustained-release tablet Within Guidelines 02218488 MERREM - 500MG/VIAL meropenem J01DH powder for injectable solution Within Guidelines 02218496 MERREM - 1000MG/VIAL meropenem J01DH powder for injectable solution Within Guidelines 02219018 MERREM ADD-VANTAGE - 500MG/VIAL meropenem J01DH powder for injectable solution not sold No Current Sales 02219026 MERREM ADD-VANTAGE - 1000MG/VIAL meropenem J01DH powder for injectable solution not sold No Current Sales 02229411 NAROPIN - 2MG/ML ropivacaine hydrochloride N01BB injectable solution Within Guidelines 02229415 NAROPIN - 5MG/ML ropivacaine hydrochloride N01BB injectable solution Within Guidelines 02229416 NAROPIN - 7.5MG/ML ropivacaine hydrochloride N01BB injectable solution not sold No Current Sales 02229418 NAROPIN - 10MG/ML ropivacaine hydrochloride N01BB injectable solution Within Guidelines 02300524 NEXIUM - 10MG/POUCH esomeprazole magnesium A02BC powder for oral suspension not sold No Current Sales 02244521 NEXIUM - 20MG/TAB esomeprazole magnesium A02BC sustained-release tablet Within Guidelines www.pmprb-cepmb.gc.ca

4 Canadian Patentees and Patented Drug Products for Human Use DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status ASTRAZENECA CANADA INC. (continued) 02244522 NEXIUM - 40MG/TAB esomeprazole magnesium A02BC sustained-release tablet Within Guidelines 02237225 OXEZE TURBUHALER - 0.006MG/DOSE formoterol fumarate R03AC powder for inhalation expired Within Guidelines 02237224 OXEZE TURBUHALER - 0.012MG/DOSE formoterol fumarate R03AC powder for inhalation expired Within Guidelines 00627127 PENGLOBE - 400MG/TAB bacampicillin hydrochloride J01CA tablet not sold No Current Sales 00627135 PENGLOBE - 800MG/TAB bacampicillin hydrochloride J01CA tablet not sold No Current Sales 02057778 PLENDIL - 2.5MG/TAB felodipine C08CA sustained-release tablet Within Guidelines 00851779 PLENDIL - 5MG/TAB felodipine C08CA sustained-release tablet Within Guidelines 00851787 PLENDIL - 10MG/TAB felodipine C08CA sustained-release tablet Within Guidelines 00817228 PULMICORT INHALER - 0.05MG/DOSE budesonide R03BA aerosol for inhalation not sold No Current Sales 00634549 PULMICORT INHALER - 0.2MG/DOSE budesonide R03BA aerosol for inhalation not sold No Current Sales 02229099 PULMICORT NEBUAMP - 0.125MG/ML budesonide R03BA suspension for inhalation Within Guidelines 01978918 PULMICORT NEBUAMP - 0.25MG/ML budesonide R03BA suspension for inhalation Within Guidelines 01978926 PULMICORT NEBUAMP - 0.5MG/ML budesonide R03BA suspension for inhalation Within Guidelines 00634530 PULMICORT SPACER - 0.05MG/DOSE budesonide R03BA aerosol for inhalation not sold No Current Sales 00814091 PULMICORT SPACER - 0.2MG/DOSE budesonide R03BA aerosol for inhalation not sold No Current Sales 00852074 PULMICORT TURBUHALER - 0.1MG/DOSE budesonide R03BA powder for inhalation Within Guidelines 00851752 PULMICORT TURBUHALER - 0.2MG/DOSE budesonide R03BA powder for inhalation Within Guidelines 00851760 PULMICORT TURBUHALER - 0.4MG/DOSE budesonide R03BA powder for inhalation Within Guidelines 02051788 RAMACE - 1.25MG/CAP ramipril C09AA capsule not sold No Current Sales 02051796 RAMACE - 2.5MG/CAP ramipril C09AA capsule not sold No Current Sales 02051818 RAMACE - 5MG/CAP ramipril C09AA capsule not sold No Current Sales 02242874 RAMACE - 10MG/CAP ramipril C09AA capsule not sold No Current Sales 00636460 RHINOCORT - 0.05MG/DOSE budesonide R01AD nasal aerosol not sold No Current Sales 02231922 RHINOCORT AQUA - 0.032MG/DOSE budesonide R01AD nasal aerosol not sold No Current Sales 01974424 RHINOCORT AQUA - 0.05MG/DOSE budesonide R01AD nasal aerosol not sold No Current Sales 02231923 RHINOCORT AQUA - 0.064MG/DOSE budesonide R01AD nasal aerosol Within Guidelines 01974432 RHINOCORT AQUA - 0.1MG/DOSE budesonide R01AD nasal aerosol not sold No Current Sales 02035324 RHINOCORT TURBUHALER - 0.1MG/DOSE budesonide R01AD powder for nasal inhalation Within Guidelines 02035340 RHINOCORT TURBUHALER - 0.2MG/DOSE budesonide R01AD powder for nasal inhalation not sold No Current Sales 02236951 SEROQUEL - 25MG/TAB quetiapine fumarate N05AH tablet Within Guidelines 02236952 SEROQUEL - 100MG/TAB quetiapine fumarate N05AH tablet Within Guidelines 02240862 SEROQUEL - 150MG/TAB quetiapine fumarate N05AH tablet not sold No Current Sales 02236953 SEROQUEL - 200MG/TAB quetiapine fumarate N05AH tablet Within Guidelines 02244107 SEROQUEL - 300MG/TAB quetiapine fumarate N05AH tablet Within Guidelines 02300184 SEROQUEL XR - 50MG/TAB quetiapine fumarate N05AH sustained-release tablet introduced Within Guidelines 02300192 SEROQUEL XR - 200MG/TAB quetiapine fumarate N05AH sustained-release tablet introduced Within Guidelines 02300206 SEROQUEL XR - 300MG/TAB quetiapine fumarate N05AH sustained-release tablet introduced Within Guidelines 02300214 SEROQUEL XR - 400MG/TAB quetiapine fumarate N05AH sustained-release tablet introduced Within Guidelines 02245385 SYMBICORT 100/6 TURBUHALER budesonide/formoterol fumarate R03AK powder for inhalation Within Guidelines 02245386 SYMBICORT 200/6 TURBUHALER budesonide/formoterol fumarate R03AK powder for inhalation Within Guidelines 02248218 SYMBICORT FORTE 400/12 TURBUH budesonide/formoterol fumarate R03AK powder for inhalation not sold No Current Sales 02229566 TOMUDEX - 2MG/VIAL raltitrexed L01BA powder for injectable solution Within Guidelines 02103729 ZESTORETIC 10/12.5 lisinopril/hydrochlorothiazide C09BA tablet Within Guidelines 02045737 ZESTORETIC 20/12.5 lisinopril/hydrochlorothiazide C09BA tablet Within Guidelines 02045729 ZESTORETIC 20/25 lisinopril/hydrochlorothiazide C09BA tablet Within Guidelines 02049333 ZESTRIL - 5MG/TAB lisinopril C09AA tablet expired Within Guidelines 02049376 ZESTRIL - 10MG/TAB lisinopril C09AA tablet expired Within Guidelines 02049384 ZESTRIL - 20MG/TAB lisinopril C09AA tablet expired Within Guidelines 00839345 ZESTRIL - 40MG/TAB lisinopril C09AA tablet expired No Current Sales 02248992 ZOMIG - 2.5MG/DOSE zolmitriptan N02CC nasal spray Within Guidelines 02248993 ZOMIG - 5MG/DOSE zolmitriptan N02CC nasal spray Within Guidelines 02238660 ZOMIG - 2.5MG/TAB zolmitriptan N02CC tablet Within Guidelines

02243045 ZOMIG RAPIMELT - 2.5MG/TAB zolmitriptan N02CC orally disintegrating tablet Within Guidelines www.pmprb-cepmb.gc.ca January 1 — December 31, 2007 Annual Report 2007 5 DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status AXCAN PHARMA INC. 02246962 HELIZIDE 140/125/125 biskalcitrate potassium/metronidazole/ A02BD capsule not sold No Current Sales tetracycline hydro 02020033 PHOTOFRIN - 15MG/VIAL porfimer sodium L01XX powder for injectable solution Within Guidelines 02019876 PHOTOFRIN - 75MG/VIAL porfimer sodium L01XX powder for injectable solution Within Guidelines 02238984 URSO - 250MG/TAB ursodiol A05AA tablet Within Guidelines 02245894 URSO DS - 500MG/TAB ursodiol A05AA tablet Within Guidelines 01945254 URSOFALK - 250MG/CAP ursodiol A05AA capsule not sold No Current Sales

BARRIER THERAPEUTICS CANADA INC. 02238848 DENAVIR - 10MG/G penciclovir D06BB topical cream Subj. Investigation 02243257 SOLAGÉ mequinol/tretinoin D11AX topical solution Within Guidelines 02243837 VANIQA - 139MG/G eflornithine hydrochloride D11AX topical cream VCU

BAXTER CORPORATION 02284154 ADVATE 1000 antihemophilic factor, recombinant B02BD powder for injectable solution Within Guidelines 02284162 ADVATE 1500 antihemophilic factor, recombinant B02BD powder for injectable solution Within Guidelines 02284138 ADVATE 250 antihemophilic factor, recombinant B02BD powder for injectable solution Within Guidelines 02284146 ADVATE 500 antihemophilic factor, recombinant B02BD powder for injectable solution Within Guidelines 02188880 BREVIBLOC - 10MG/ML esmolol hydrochloride C07AB injectable solution Within Guidelines 02188872 BREVIBLOC - 100MG/ML esmolol hydrochloride C07AB injectable solution not sold No Current Sales 02188864 BREVIBLOC - 250MG/ML esmolol hydrochloride C07AB injectable solution Within Guidelines 02230772 CRITILIP 20% medium and long chain triglycerides B05BA injectable suspension not sold No Current Sales 02202581 FEIBA VH IMMUNO factor VIII anti inhibitor B02BD powder for injectable solution Within Guidelines 02264625 FSME-IMMUN - 2.4MCG/VIAL tick-borne encephalitis vaccine (inactivated) J07BA injectable suspension Within Guidelines 02241357 IFEX - 1000MG/VIAL ifosfamide L01AA powder for injectable solution Under Review 02241356 IFEX - 3000MG/VIAL ifosfamide L01AA powder for injectable solution Under Review 02206021 IMMUNINE VH factor IX (human) B02BD powder for injectable solution Within Guidelines 00719603 KRYOBULIN VH factor VIII complex (human) B02BD powder for injectable solution not sold No Current Sales 00719811 KRYOBULIN VH factor VIII complex (human) B02BD powder for injectable solution not sold No Current Sales 00719838 KRYOBULIN VH factor VIII complex (human) B02BD powder for injectable solution not sold No Current Sales 02230810 NUTRINEAL PD4 amino acids + electrolytes B05ZA peritoneal dialysis solution Under Review 02241797 PROCYTOX - 200MG/VIAL cyclophosphamide L01AA powder for injectable solution Under Review 02241798 PROCYTOX - 500MG/VIAL cyclophosphamide L01AA powder for injectable solution Under Review 02241799 PROCYTOX - 1000MG/VIAL cyclophosphamide L01AA powder for injectable solution Under Review 02241800 PROCYTOX - 2000MG/VIAL cyclophosphamide L01AA powder for injectable solution Under Review 02227428 SUPRANE desflurane N01AB inhalation anesthetic Subj. Investigation 01958968 TISSEEL KIT VH 0.5 fibrin sealant B02BC powder for topical solution not sold No Current Sales 02233273 TISSEEL KIT VH 1.0 fibrin sealant B02BC powder for topical solution Within Guidelines 02233274 TISSEEL KIT VH 2.0 fibrin sealant B02BC powder for topical solution Within Guidelines 02233275 TISSEEL KIT VH 5.0 fibrin sealant B02BC powder for topical solution Within Guidelines 02241411 UROMITEXAN - 100MG/ML mesna V03AF injectable solution Under Review

BAYER INC. 02246414 AVELOX - 1.6MG/ML moxifloxacin hydrochloride J01MA injectable solution Within Guidelines 02242965 AVELOX - 400MG/TAB moxifloxacin hydrochloride J01MA tablet Within Guidelines 02237325 BAYCOL - 0.2MG/TAB cerivastatin sodium C10AA tablet not sold No Current Sales 02237326 BAYCOL - 0.3MG/TAB cerivastatin sodium C10AA tablet not sold No Current Sales 02241466 BAYCOL - 0.4MG/TAB cerivastatin sodium C10AA tablet not sold No Current Sales 02243223 BAYCOL - 0.8MG/TAB cerivastatin sodium C10AA tablet not sold No Current Sales 02169649 BETASERON - 0.3MG/VIAL interferon beta-1b L03AB powder for injectable solution Within Guidelines 02237513 CIPRO - 50MG/ML ciprofloxacin J01MA powder for oral suspension not sold No Current Sales www.pmprb-cepmb.gc.ca

6 Canadian Patentees and Patented Drug Products for Human Use DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status BAYER INC. (continued) 02237514 CIPRO - 100MG/ML ciprofloxacin J01MA powder for oral suspension Within Guidelines 02155931 CIPRO - 100MG/TAB ciprofloxacin hydrochloride J01MA tablet not sold No Current Sales 02155958 CIPRO - 250MG/TAB ciprofloxacin hydrochloride J01MA tablet Within Guidelines 02155966 CIPRO - 500MG/TAB ciprofloxacin hydrochloride J01MA tablet Within Guidelines 02155974 CIPRO - 750MG/TAB ciprofloxacin hydrochloride J01MA tablet Subj. Investigation 02237334 CIPRO IV - 2MG/ML ciprofloxacin lactate J01MA injectable solution Within Guidelines 02155982 CIPRO IV - 10MG/ML ciprofloxacin lactate J01MA injectable solution not sold No Current Sales 02247916 CIPRO XL - 500MG/TAB ciprofloxacin hydrochloride J01MA extended-release tablet Within Guidelines 02251787 CIPRO XL - 1000MG/TAB ciprofloxacin hydrochloride J01MA extended-release tablet Within Guidelines 02231510 CLIMARA 100 - 7.6MG/PATCH estradiol 17ß G03CA transdermal patch Within Guidelines 02247499 CLIMARA 25 - 2MG/PATCH estradiol 17ß G03CA transdermal patch Within Guidelines 02231509 CLIMARA 50 - 3.8MG/PATCH estradiol 17ß G03CA transdermal patch Within Guidelines 02247500 CLIMARA 75 - 5.7MG/PATCH estradiol 17ß G03CA transdermal patch Within Guidelines 02241088 GADOVIST 0.5 - 302.36MG/ML gadobutrol V08CA injectable solution not sold No Current Sales 02241089 GADOVIST 1.0 - 604.72MG/ML gadobutrol V08CA injectable solution Within Guidelines 02178842 GAMIMUNE N - 50MG/ML immune globulin intravenous (human) J06BA injectable solution not sold No Current Sales 02229695 GAMIMUNE N - 100MG/ML immune globulin intravenous (human) J06BA injectable solution not sold No Current Sales GAMIMUNE N HT - 50MG/ML immune globulin intravenous (human) J06BA injectable solution not sold No Current Sales 02190885 GLUCOBAY - 50MG/TAB acarbose A10BF tablet Within Guidelines 02190893 GLUCOBAY - 100MG/TAB acarbose A10BF tablet Within Guidelines 02187825 KOATE-HP - 250UNIT/VIAL antihemophilic factor (human) B02BD powder for injectable solution not sold No Current Sales 02187833 KOATE-HP - 500UNIT/VIAL antihemophilic factor (human) B02BD powder for injectable solution not sold No Current Sales 02187841 KOATE-HP - 1000UNIT/VIAL antihemophilic factor (human) B02BD powder for injectable solution not sold No Current Sales 02187868 KOATE-HP - 1500UNIT/VIAL antihemophilic factor (human) B02BD powder for injectable solution not sold No Current Sales 02242491 KOGENATE FS 1000 antihemophilic factor (recombinant) B02BD powder for injectable solution not sold No Current Sales 02242489 KOGENATE FS 250 antihemophilic factor (recombinant) B02BD powder for injectable solution not sold No Current Sales 02242490 KOGENATE FS 500 antihemophilic factor (recombinant) B02BD powder for injectable solution not sold No Current Sales 02254492 KOGENATE FS BIOSET 1000 antihemophilic factor (recombinant) B02BD powder for injectable solution Within Guidelines 02254476 KOGENATE FS BIOSET 250 antihemophilic factor (recombinant) B02BD powder for injectable solution Within Guidelines 02254484 KOGENATE FS BIOSET 500 antihemophilic factor (recombinant) B02BD powder for injectable solution Within Guidelines 02250462 LEVITRA - 5MG/TAB vardenafil hydrochloride G04BE tablet Within Guidelines 02250470 LEVITRA - 10MG/TAB vardenafil hydrochloride G04BE tablet Within Guidelines 02250489 LEVITRA - 20MG/TAB vardenafil hydrochloride G04BE tablet Within Guidelines 02227347 LEVOVIST 999/1 galactose/palmitic acid V08DA powder for injectable solution not sold No Current Sales 02229102 LEVOVIST 999/1 galactose/palmitic acid V08DA powder for injectable solution not sold No Current Sales 02273993 MABCAMPATH - 30MG/AMPOULE alemtuzumab L01XC injectable solution Within Guidelines 01989987 MAGNEVIST - 469MG/ML gadopentetate dimeglumine V08CA injectable solution Within Guidelines 02243005 MIRENA - 52MG/POUCH levonorgestrel G02BA intra-uterine device Within Guidelines 02284227 NEXAVAR - 200MG/TAB sorafenib tosylate L01XE tablet introduced (nas) Within Guidelines 02240996 REFLUDAN - 50MG/VIAL lepirudin B01AE powder for injectable solution Within Guidelines 02266121 SATIVEX 27/25 delta-9-tetrahydrocannabinol/cannabidiol N02BG buccal spray Within Guidelines 02189135 THROMBATE III - 500UNIT/VIAL antithrombin III B01AB powder for injectable solution not sold No Current Sales 02189143 THROMBATE III - 1000UNIT/VIAL antithrombin III B01AB powder for injectable solution not sold No Current Sales 02286319 VASOVIST - 244MG/ML gadofosveset trisodium V08CA injectable solution introduced (nas) Within Guidelines 02261723 YASMIN 21 3/.03 drospirenone/ethinyl estradiol G03AA tablet Within Guidelines 02261731 YASMIN 28 3/.03 drospirenone/ethinyl estradiol G03AA tablet Within Guidelines

BIOGEN IDEC CANADA INC. 02286386 TYSABRI - 20MG/ML natalizumab L04AA powder for injectable solution Subj. Investigation www.pmprb-cepmb.gc.ca

January 1 — December 31, 2007 Annual Report 2007 7 DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status BIOVAIL PHARMACEUTICALS CANADA 02247791 ATTENADE - 2.5MG/TAB dexmethylphenidate hydrochloride N06BA tablet not sold No Current Sales 02247792 ATTENADE - 5MG/TAB dexmethylphenidate hydrochloride N06BA tablet not sold No Current Sales 02247793 ATTENADE - 10MG/TAB dexmethylphenidate hydrochloride N06BA tablet not sold No Current Sales 02268493 GLUMETZA - 500MG/TAB metformin hydrochloride A10BA extended-release tablet Subj. Investigation 02268507 GLUMETZA - 1000MG/TAB metformin hydrochloride A10BA extended-release tablet not sold No Current Sales 02233013 RETAVASE - 10.4UNIT/VIAL reteplase B01AD powder for injectable solution Within Guidelines 02231150 TIAZAC - 120MG/CAP diltiazem hydrochloride C08DB extended-release capsule Within Guidelines 02231151 TIAZAC - 180MG/CAP diltiazem hydrochloride C08DB extended-release capsule Within Guidelines 02231152 TIAZAC - 240MG/CAP diltiazem hydrochloride C08DB extended-release capsule Within Guidelines 02231154 TIAZAC - 300MG/CAP diltiazem hydrochloride C08DB extended-release capsule Within Guidelines 02231155 TIAZAC - 360MG/CAP diltiazem hydrochloride C08DB extended-release capsule Within Guidelines 02256738 TIAZAC XC - 120MG/TAB diltiazem hydrochloride C08DB extended-release tablet Within Guidelines 02256746 TIAZAC XC - 180MG/TAB diltiazem hydrochloride C08DB extended-release tablet Within Guidelines 02256754 TIAZAC XC - 240MG/TAB diltiazem hydrochloride C08DB extended-release tablet Within Guidelines 02256762 TIAZAC XC - 300MG/TAB diltiazem hydrochloride C08DB extended-release tablet Within Guidelines 02256770 TIAZAC XC - 360MG/TAB diltiazem hydrochloride C08DB extended-release tablet Within Guidelines 02237823 WELLBUTRIN SR - 50MG/TAB bupropion hydrochloride N07BA sustained-release tablet not sold No Current Sales 02237824 WELLBUTRIN SR - 100MG/TAB bupropion hydrochloride N07BA sustained-release tablet Within Guidelines 02237825 WELLBUTRIN SR - 150MG/TAB bupropion hydrochloride N07BA sustained-release tablet Within Guidelines 02275090 WELLBUTRIN XL - 150MG/TAB bupropion hydrochloride N07BA extended-release tablet Within Guidelines 02275104 WELLBUTRIN XL - 300MG/TAB bupropion hydrochloride N07BA extended-release tablet Within Guidelines 02238441 ZYBAN - 150MG/TAB bupropion hydrochloride N07BA sustained-release tablet Within Guidelines

BLES BIOCHEMICALS INC. 02245464 BLES - 27MG/ML phospholipids+surfactant-associated proteins B&C R07AA intratracheal suspension Within Guidelines

BOEHRINGER INGELHEIM (CANADA) LTD. 02242119 AGGRENOX 200/25 dipyridamole/ASA B01AC sustained-release capsule Within Guidelines 02273322 APTIVUS - 250MG/CAP tipranavir J05AE capsule Within Guidelines 02247686 ATROVENT HFA - 0.02MG/DOSE ipratropium bromide R03BB aerosol for inhalation Within Guidelines 02238123 FLOMAX - 0.4MG/CAP tamsulosin hydrochloride G04CA sustained-release capsule Within Guidelines 02270102 FLOMAX CR - 0.4MG/TAB tamsulosin hydrochloride G04CA controlled-release tablet Within Guidelines 02240769 MICARDIS - 40MG/TAB telmisartan C09CA tablet Within Guidelines 02240770 MICARDIS - 80MG/TAB telmisartan C09CA tablet Within Guidelines 02244344 MICARDIS PLUS telmisartan/hydrochlorothiazide C09DA tablet Within Guidelines 02297256 MIRAPEX - 0.125MG/TAB pramipexole dihydrochloride N04BC tablet not sold No Current Sales 02237145 MIRAPEX - 0.25MG/TAB pramipexole dihydrochloride N04BC tablet Within Guidelines 02241594 MIRAPEX - 0.5MG/TAB pramipexole dihydrochloride N04BC tablet Within Guidelines 02237146 MIRAPEX - 1MG/TAB pramipexole dihydrochloride N04BC tablet Within Guidelines 02237147 MIRAPEX - 1.5MG/TAB pramipexole dihydrochloride N04BC tablet Within Guidelines 02246793 SPIRIVA - 18MCG/CAP tiotropium bromide R03BB powder for inhalation Within Guidelines 02238748 VIRAMUNE - 200MG/TAB nevirapine J05AG tablet Within Guidelines

BRACCO DIAGNOSTICS CANADA INC. 02248302 MULTIHANCE - 529MG/ML gadobenate dimeglumine V08CA injectable solution Within Guidelines 02229056 PROHANCE - 279.3MG/ML gadoteridol V08CA injectable solution Within Guidelines 02248152 SONOVUE - 8MCL/ML sulfur hexafluoride V04CX powder for injectable suspension not sold No Current Sales

BRADLEY PHARMACEUTICALS INC. 02238019 SOLARAZE - 30MG/G diclofenac sodium D11AX topical gel not sold No Current Sales www.pmprb-cepmb.gc.ca

8 Canadian Patentees and Patented Drug Products for Human Use DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status BRISTOL-MYERS SQUIBB CANADA CO. 99MTC TECHNESCAN MAG3 UD PED. technetium Tc-99m mertiatide V09CA powder for injectable solution not sold No Current Sales 99MTC TECHNESCAN MAG3 UD REG. technetium Tc-99m mertiatide V09CA powder for injectable solution Within Guidelines 02241818 AVALIDE 150/12.5 irbesartan/hydrochlorothiazide C09DA tablet Within Guidelines 02241819 AVALIDE 300/12.5 irbesartan/hydrochlorothiazide C09DA tablet Within Guidelines 02280213 AVALIDE 300/25 irbesartan/hydrochlorothiazide C09DA tablet Within Guidelines 02237923 AVAPRO - 75MG/TAB irbesartan C09CA tablet Within Guidelines 02237924 AVAPRO - 150MG/TAB irbesartan C09CA tablet Within Guidelines 02237925 AVAPRO - 300MG/TAB irbesartan C09CA tablet Within Guidelines 01911570 AZACTAM - 500MG/VIAL aztreonam J01DF powder for injectable solution not sold No Current Sales 01911562 AZACTAM - 1000MG/VIAL aztreonam J01DF powder for injectable solution Within Guidelines 01911554 AZACTAM - 2000MG/VIAL aztreonam J01DF powder for injectable solution not sold No Current Sales 02282232 BARACLUDE - 0.05MG/ML entecavir J05AF oral solution not sold No Current Sales 02282224 BARACLUDE - 0.5MG/TAB entecavir J05AF tablet Within Guidelines 02211114 BIANDA - 25MG/VIAL losoxantrone hydrochloride L01XX powder for injectable solution expired No Current Sales CARDIOLITE/MIRALUMA technetium Tc-99m sestamibi V09GA powder for injectable solution Within Guidelines 02163675 CEFZIL - 25MG/ML cefprozil J01DA powder for oral suspension Within Guidelines 02163683 CEFZIL - 50MG/ML cefprozil J01DA powder for oral suspension Within Guidelines 02163659 CEFZIL - 250MG/TAB cefprozil J01DA tablet Within Guidelines 02163667 CEFZIL - 500MG/TAB cefprozil J01DA tablet Within Guidelines 02243173 DEFINITY - 150MCL/ML perflutren V08DA injectable suspension Subj. Investigation 02271249 ERBITUX - 100MG/VIAL cetuximab L01XC injectable solution Within Guidelines 02230986 ETOPOPHOS - 100MG/VIAL etoposide phosphate L01CB powder for injectable solution not sold No Current Sales 02168529 MAXIPIME - 1000MG/BOTTLE cefepime hydrochloride J01DA powder for injectable solution not sold No Current Sales 02168863 MAXIPIME - 2000MG/BOTTLE cefepime hydrochloride J01DA powder for injectable solution not sold No Current Sales 02163624 MAXIPIME - 500MG/VIAL cefepime hydrochloride J01DA powder for injectable solution not sold No Current Sales 02163632 MAXIPIME - 1000MG/VIAL cefepime hydrochloride J01DA powder for injectable solution Within Guidelines 02163640 MAXIPIME - 2000MG/VIAL cefepime hydrochloride J01DA powder for injectable solution Within Guidelines 01907093 MONOPRIL - 5MG/TAB fosinopril C09AA tablet not sold No Current Sales 01907107 MONOPRIL - 10MG/TAB fosinopril C09AA tablet Within Guidelines 01907115 MONOPRIL - 20MG/TAB fosinopril C09AA tablet Within Guidelines NEUROLITE - 20MCI/TEST technetium Tc-99m bicisate V09AA powder for injectable solution expired Subj. Investigation OCTREOSCAN - 3.3MCI/VIAL in-111 pentetreotide V09IB injectable solution VCU 02282097 ORENCIA - 250MG/VIAL abatacept L04AA powder for injectable solution introduced (nas) Within Guidelines 02238682 PLAVIX - 75MG/TAB clopidogrel bisulfate B01AC tablet Within Guidelines 00893749 PRAVACHOL - 10MG/TAB pravastatin sodium C10AA tablet Within Guidelines 00893757 PRAVACHOL - 20MG/TAB pravastatin sodium C10AA tablet Within Guidelines 02222051 PRAVACHOL - 40MG/TAB pravastatin sodium C10AA tablet Within Guidelines 02250330 PRAVACHOL - 80MG/TAB pravastatin sodium C10AA tablet not sold No Current Sales 02248609 REYATAZ - 100MG/CAP atazanavir sulfate J05AE capsule not sold No Current Sales 02248610 REYATAZ - 150MG/CAP atazanavir sulfate J05AE capsule Within Guidelines 02248611 REYATAZ - 200MG/CAP atazanavir sulfate J05AE capsule Within Guidelines 02294176 REYATAZ - 300MG/CAP atazanavir sulfate J05AE capsule introduced Within Guidelines 02028786 SINEMET CR 25/100 carbidopa/levodopa N04BA controlled-release tablet Within Guidelines 00870935 SINEMET CR 50/200 carbidopa/levodopa N04BA controlled-release tablet Within Guidelines 02239886 SUSTIVA - 50MG/CAP efavirenz J05AG capsule Within Guidelines 02239887 SUSTIVA - 100MG/CAP efavirenz J05AG capsule Within Guidelines 02239888 SUSTIVA - 200MG/CAP efavirenz J05AG capsule Within Guidelines 02246044 SUSTIVA - 300MG/TAB efavirenz J05AG tablet not sold No Current Sales 02246045 SUSTIVA - 600MG/TAB efavirenz J05AG tablet Within Guidelines 02016796 TAXOL - 6MG/ML paclitaxel L01CD injectable solution Within Guidelines TECHNESCAN MAG3 technetium Tc-99m mertiatide V09CA powder for injectable solution Subj. Investigation www.pmprb-cepmb.gc.ca

January 1 — December 31, 2007 Annual Report 2007 9 DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status BRISTOL-MYERS SQUIBB CANADA CO. (continued) 02243183 TEQUIN - 2MG/ML gatifloxacin J01MA injectable solution not sold No Current Sales 02243184 TEQUIN - 10MG/ML gatifloxacin J01MA injectable solution not sold No Current Sales 02243181 TEQUIN - 200MG/TAB gatifloxacin J01MA tablet not sold No Current Sales 02243182 TEQUIN - 400MG/TAB gatifloxacin J01MA tablet not sold No Current Sales 00616192 VEPESID - 50MG/CAP etoposide L01CB capsule Within Guidelines 00523410 VEPESID - 20MG/ML etoposide L01CB injectable solution not sold Subj. Investigation 01940511 VIDEX - 25MG/TAB didanosine J05AF chewable tablet not sold No Current Sales 01940538 VIDEX - 50MG/TAB didanosine J05AF chewable tablet not sold No Current Sales 01940546 VIDEX - 100MG/TAB didanosine J05AF chewable tablet Within Guidelines 01940554 VIDEX - 150MG/TAB didanosine J05AF chewable tablet not sold No Current Sales 01940589 VIDEX - 100MG/VIAL didanosine J05AF powder for oral solution not sold No Current Sales 01940597 VIDEX - 167MG/VIAL didanosine J05AF powder for oral solution not sold No Current Sales 01940600 VIDEX - 250MG/VIAL didanosine J05AF powder for oral solution not sold No Current Sales 01940619 VIDEX - 375MG/VIAL didanosine J05AF powder for oral solution not sold No Current Sales 01940627 VIDEX - 2000MG/VIAL didanosine J05AF powder for oral solution not sold No Current Sales 01940635 VIDEX - 4000MG/VIAL didanosine J05AF powder for oral solution Within Guidelines 02244596 VIDEX EC - 125MG/CAP didanosine J05AF sustained-release capsule Within Guidelines 02244597 VIDEX EC - 200MG/CAP didanosine J05AF sustained-release capsule Within Guidelines 02244598 VIDEX EC - 250MG/CAP didanosine J05AF sustained-release capsule Within Guidelines 02244599 VIDEX EC - 400MG/CAP didanosine J05AF sustained-release capsule Within Guidelines 02216078 ZERIT - 5MG/CAP stavudine J05AF capsule not sold No Current Sales 02216086 ZERIT - 15MG/CAP stavudine J05AF capsule Within Guidelines 02216094 ZERIT - 20MG/CAP stavudine J05AF capsule Within Guidelines 02216108 ZERIT - 30MG/CAP stavudine J05AF capsule Within Guidelines 02216116 ZERIT - 40MG/CAP stavudine J05AF capsule Within Guidelines 02237009 ZERIT - 1MG/ML stavudine J05AF powder for oral solution not sold No Current Sales 02247912 ZERIT XR - 37.5MG/CAP stavudine J05AF extended-release capsule not sold No Current Sales 02247913 ZERIT XR - 50MG/CAP stavudine J05AF extended-release capsule not sold No Current Sales 02247914 ZERIT XR - 75MG/CAP stavudine J05AF extended-release capsule not sold No Current Sales 02247915 ZERIT XR - 100MG/CAP stavudine J05AF extended-release capsule not sold No Current Sales

CANDERM PHARMA INC. 01945149 CONDYLINE - 5MG/ML podofilox D06BB topical solution expired Within Guidelines 02221470 DERMAGRAN II - 2.5MG/G magnesium hydroxide D02AB topical ointment Within Guidelines 02221489 DERMAGRAN II - 1MG/ML zinc chloride D02AB topical spray not sold No Current Sales

CELGENE CORPORATION THALOMID - 50MG/CAP thalidomide L04AX capsule Under Review

COOK IMAGING CORPORATION 02240929 OXILAN 300 ioxilan V08AB injectable solution not sold No Current Sales 02240930 OXILAN 350 ioxilan V08AB injectable solution not sold No Current Sales

DAIICHI PHARMACEUTICAL CORPORATION 02242360 FLOXIN - 3MG/ML ofloxacin S01AA otic solution not sold No Current Sales

DISTA PRODUCTS LIMITED 01968041 TALIDAN - 10MG/CAP fluoxetine hydrochloride N06AB capsule expired No Current Sales 01968033 TALIDAN - 20MG/CAP fluoxetine hydrochloride N06AB capsule expired No Current Sales www.pmprb-cepmb.gc.ca

10 Canadian Patentees and Patented Drug Products for Human Use DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status DUCHESNAY INC. 00609129 DICLECTIN doxylamine succinate/pyridoxine hydrochloride R06AA delayed-release tablet Subj. Investigation 02246067 PREGVIT multivitamins-minerals B03AE tablet Under Review 02276194 PREGVIT FOLIC 5 multivitamins-minerals B03AE tablet Under Review

ELAN PHARMACEUTICALS INC. 02057735 PROSTEP 11 - 15MG/PATCH nicotine N07BA transdermal patch not sold No Current Sales 02057743 PROSTEP 22 - 30MG/PATCH nicotine N07BA transdermal patch not sold No Current Sales

ELI LILLY CANADA INC. 02242572 ACTOS - 15MG/TAB pioglitazone hydrochloride A10BG tablet Within Guidelines 02242573 ACTOS - 30MG/TAB pioglitazone hydrochloride A10BG tablet Within Guidelines 02242574 ACTOS - 45MG/TAB pioglitazone hydrochloride A10BG tablet Within Guidelines 02253437 ALIMTA - 500MG/VIAL pemetrexed disodium L01BA powder for injectable solution Within Guidelines 00778338 AXID - 150MG/CAP nizatidine A02BA capsule not sold No Current Sales 00778346 AXID - 300MG/CAP nizatidine A02BA capsule not sold No Current Sales 02161761 CECLOR CD - 375MG/TAB cefaclor J01DA sustained-release tablet not sold No Current Sales 02161788 CECLOR CD - 500MG/TAB cefaclor J01DA sustained-release tablet not sold No Current Sales 02296888 CIALIS - 2.5MG/TAB tadalafil G04BE tablet not sold No Current Sales 02296896 CIALIS - 5MG/TAB tadalafil G04BE tablet not sold No Current Sales 02248088 CIALIS - 10MG/TAB tadalafil G04BE tablet Within Guidelines 02248089 CIALIS - 20MG/TAB tadalafil G04BE tablet Within Guidelines 02301482 CYMBALTA - 30MG/CAP duloxetine hydrochloride N06AX delayed-release capsule not sold No Current Sales 02301490 CYMBALTA - 60MG/CAP duloxetine hydrochloride N06AX delayed-release capsule not sold No Current Sales 02229863 DYNABAC - 250MG/TAB dirithromycin J01FA tablet expired No Current Sales 02218054 ETHYOL - 500MG/VIAL amifostine V03AF powder for injectable solution not sold No Current Sales 02239028 EVISTA - 60MG/TAB raloxifene hydrochloride G03XC tablet Within Guidelines 02254689 FORTEO - 250MCG/ML teriparatide H05AA injectable solution VCU 02230308 GEMZAR - 200MG/VIAL gemcitabine hydrochloride L01BC powder for injectable solution Within Guidelines 02230309 GEMZAR - 1000MG/VIAL gemcitabine hydrochloride L01BC powder for injectable solution Within Guidelines 02229704 HUMALOG - 100UNIT/ML insulin lispro A10AB injectable solution Within Guidelines 02229705 HUMALOG - 100UNIT/ML insulin lispro A10AB injectable solution Within Guidelines 02240294 HUMALOG MIX 25/75 - 100UNIT/ML insulin (lispro/lispro protamine) A10AB injectable solution Within Guidelines 02240296 HUMALOG MIX 25/75 - 100UNIT/ML insulin (lispro/lispro protamine) A10AB injectable solution not sold No Current Sales 02240295 HUMALOG MIX 25/75 PEN - 100UNIT/ML insulin (lispro/lispro protamine) A10AB injectable solution Within Guidelines 02240297 HUMALOG MIX 50/50 - 100UNIT/ML insulin (lispro/lispro protamine) A10AB injectable solution introduced Within Guidelines 02240299 HUMALOG MIX 50/50 - 100UNIT/ML insulin (lispro/lispro protamine) A10AB injectable solution not sold No Current Sales 02240298 HUMALOG MIX 50/50 PEN - 100UNIT/ML insulin (lispro/lispro protamine) A10AB injectable solution not sold No Current Sales 02241283 HUMALOG PEN - 100UNIT/ML insulin lispro A10AB injectable solution Within Guidelines 02243077 HUMATROPE - 6MG/CARTRIDGE somatropin H01AC powder for injectable solution Within Guidelines 02243078 HUMATROPE - 12MG/CARTRIDGE somatropin H01AC powder for injectable solution Within Guidelines 02243079 HUMATROPE - 24MG/CARTRIDGE somatropin H01AC powder for injectable solution Within Guidelines 00745626 HUMATROPE - 5MG/VIAL somatropin H01AC powder for injectable solution Within Guidelines 00752525 KEFLIN ADD-VANTAGE - 1000MG/VIAL cephalothin sodium J01DA powder for injectable solution expired No Current Sales 00752533 KEFLIN ADD-VANTAGE - 2000MG/VIAL cephalothin sodium J01DA powder for injectable solution expired No Current Sales 00411434 KEFZOL ADD-VANTAGE - 500MG/VIAL cefazolin sodium J01DA powder for injectable solution expired No Current Sales 00411442 KEFZOL ADD-VANTAGE - 1000MG/VIAL cefazolin sodium J01DA powder for injectable solution expired No Current Sales 02044757 LORABID - 200MG/CAP loracarbef J01DA capsule not sold No Current Sales 02044749 LORABID - 400MG/CAP loracarbef J01DA capsule not sold No Current Sales 02161206 LORABID - 20MG/ML loracarbef J01DA powder for oral suspension not sold No Current Sales 02161214 LORABID - 40MG/ML loracarbef J01DA powder for oral suspension not sold No Current Sales 00648930 MANDOL ADD-VANTAGE - 1000MG/VIAL cefamandole nafate J01DA powder for injectable solution expired No Current Sales www.pmprb-cepmb.gc.ca

January 1 — December 31, 2007 Annual Report 2007 11 DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status ELI LILLY CANADA INC. (continued) 00842621 MANDOL ADD-VANTAGE - 2000MG/VIAL cefamandole nafate J01DA powder for injectable solution expired No Current Sales 00851825 NEBCIN ADD-VANTAGE - 10MG/ML tobramycin sulfate J01GB injectable solution expired No Current Sales 02018985 PROZAC - 10MG/CAP fluoxetine hydrochloride N06AB capsule Within Guidelines 00636622 PROZAC - 20MG/CAP fluoxetine hydrochloride N06AB capsule Within Guidelines 02216973 REOPRO - 2MG/ML abciximab B01AC injectable solution Within Guidelines 02262800 STRATTERA - 10MG/CAP atomoxetine hydrochloride N06BA capsule Notice of Hearing 02262819 STRATTERA - 18MG/CAP atomoxetine hydrochloride N06BA capsule Notice of Hearing 02262827 STRATTERA - 25MG/CAP atomoxetine hydrochloride N06BA capsule Notice of Hearing 02262835 STRATTERA - 40MG/CAP atomoxetine hydrochloride N06BA capsule Notice of Hearing 02262843 STRATTERA - 60MG/CAP atomoxetine hydrochloride N06BA capsule Notice of Hearing 02279347 STRATTERA - 80MG/CAP atomoxetine hydrochloride N06BA capsule not sold No Current Sales 02279355 STRATTERA - 100MG/CAP atomoxetine hydrochloride N06BA capsule not sold No Current Sales 02015110 VANCOCIN - 10000MG/VIAL vancomycin hydrochloride J01XA powder for injectable solution not sold No Current Sales 00015423 VANCOCIN C.P. - 500MG/VIAL vancomycin hydrochloride J01XA powder for injectable solution not sold No Current Sales 00722146 VANCOCIN C.P. - 1000MG/VIAL vancomycin hydrochloride J01XA powder for injectable solution not sold No Current Sales 00803510 VANCOCIN C.P. ADD-VANTAGE - 500MG/VIAL vancomycin hydrochloride J01XA powder for injectable solution not sold No Current Sales 00803537 VANCOCIN C.P. ADD-VANTAGE - 1000MG/VIAL vancomycin hydrochloride J01XA powder for injectable solution not sold No Current Sales 02247129 XIGRIS - 5MG/VIAL drotrecogin alfa (activated) B01AD powder for injectable solution Within Guidelines 02247130 XIGRIS - 20MG/VIAL drotrecogin alfa (activated) B01AD powder for injectable solution Within Guidelines 02229250 ZYPREXA - 2.5MG/TAB olanzapine N05AH tablet Within Guidelines 02229269 ZYPREXA - 5MG/TAB olanzapine N05AH tablet Within Guidelines 02229277 ZYPREXA - 7.5MG/TAB olanzapine N05AH tablet Within Guidelines 02229285 ZYPREXA - 10MG/TAB olanzapine N05AH tablet Within Guidelines 02238850 ZYPREXA - 15MG/TAB olanzapine N05AH tablet Within Guidelines 02238851 ZYPREXA - 20MG/TAB olanzapine N05AH tablet introduced Within Guidelines 02247099 ZYPREXA INTRAMUSCULAR - 10MG/VIAL olanzapine N05AH powder for injectable solution Within Guidelines 02243086 ZYPREXA ZYDIS - 5MG/TAB olanzapine N05AH orally disintegrating tablet Within Guidelines 02243087 ZYPREXA ZYDIS - 10MG/TAB olanzapine N05AH orally disintegrating tablet Within Guidelines 02243088 ZYPREXA ZYDIS - 15MG/TAB olanzapine N05AH orally disintegrating tablet Within Guidelines 02243089 ZYPREXA ZYDIS - 20MG/TAB olanzapine N05AH orally disintegrating tablet introduced Within Guidelines

EMD SERONO CANADA INC. 02247766 CETROTIDE - 0.25MG/VIAL cetrorelix acetate H01CC powder for injectable solution Subj. Investigation 02247767 CETROTIDE - 3MG/VIAL cetrorelix acetate H01CC powder for injectable solution Within Guidelines 02125404 FERTINORM HP - 75UNIT/AMPOULE urofollitropin G03GA powder for injectable solution not sold No Current Sales 02125412 FERTINORM HP - 150UNIT/AMPOULE urofollitropin G03GA powder for injectable solution not sold No Current Sales

ENCYSIVE CANADA INC. 02295636 THELIN - 100MG/TAB sitaxsentan sodium C02KX tablet introduced (nas) Within Guidelines

ENZON PHARMACEUTICALS INC. 02231590 ABELCET - 5MG/ML amphotericin B lipid complex J02AA powder for injectable solution Within Guidelines

FERRING INC. 00836362 DDAVP - 0.01MG/DOSE desmopressin acetate H01BA nasal aerosol Within Guidelines 00873993 DDAVP - 0.004MG/ML desmopressin acetate H01BA injectable solution Within Guidelines 00402516 DDAVP - 0.1MG/ML desmopressin acetate H01BA nasal solution Within Guidelines 00824305 DDAVP - 0.1MG/TAB desmopressin acetate H01BA tablet Within Guidelines 00824143 DDAVP - 0.2MG/TAB desmopressin acetate H01BA tablet Within Guidelines 02284995 DDAVP MELT - 60MCG/TAB desmopressin acetate H01BA rapidly dissolving tablet Within Guidelines www.pmprb-cepmb.gc.ca

12 Canadian Patentees and Patented Drug Products for Human Use DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status FERRING INC. (continued) 02285002 DDAVP MELT - 120MCG/TAB desmopressin acetate H01BA rapidly dissolving tablet Within Guidelines 02285010 DDAVP MELT - 240MCG/TAB desmopressin acetate H01BA rapidly dissolving tablet not sold No Current Sales 02244405 FLORAZOLE ER - 750MG/TAB metronidazole P01AB sustained-release tablet Within Guidelines 02248417 GYNAZOLE.1 - 20MG/G butoconazole nitrate G01AF vaginal cream Within Guidelines 02238598 MINIRIN - 0.01MG/DOSE desmopressin acetate H01BA nasal aerosol not sold No Current Sales 02246500 MINIRIN - 0.1MG/TAB desmopressin acetate H01BA tablet Within Guidelines 02246505 MINIRIN - 0.2MG/TAB desmopressin acetate H01BA tablet not sold No Current Sales

FOURNIER PHARMA INC. 02269074 LIPIDIL EZ - 48MG/TAB fenofibrate C10AB tablet Within Guidelines 02269082 LIPIDIL EZ - 145MG/TAB fenofibrate C10AB tablet Within Guidelines 02230283 LIPIDIL MICRO - 67MG/CAP fenofibrate C10AB capsule not sold No Current Sales 02146959 LIPIDIL MICRO - 200MG/CAP fenofibrate C10AB capsule Within Guidelines 02241601 LIPIDIL SUPRA - 100MG/TAB fenofibrate C10AB tablet Within Guidelines 02241602 LIPIDIL SUPRA - 160MG/TAB fenofibrate C10AB tablet Within Guidelines 02241603 LIPIDIL SUPRA - 200MG/TAB fenofibrate C10AB tablet not sold No Current Sales

FRESENIUS KABI 02278057 VOLUVEN - 60MG/ML hetastarch B05AA injectable solution introduced (nas) Under Review

GALDERMA CANADA INC. 02256398 CLOBEX LOTION - 0.5MG/ML clobetasol propionate D07AD topical solution Within Guidelines 02256371 CLOBEX SHAMPOO - 0.5MG/ML clobetasol propionate D07AD shampoo introduced Within Guidelines 02148749 DIFFERIN - 1MG/G adapalene D10AD topical gel expired Subj. Investigation 02231592 DIFFERIN - 1MG/G adapalene D10AD topical cream expired Within Guidelines 02148757 DIFFERIN - 1MG/ML adapalene D10AD topical solution expired No Current Sales 02274000 DIFFERIN XP - 3MG/G adapalene D10AD topical gel introduced Within Guidelines 02092832 METROGEL - 7.5MG/G metronidazole D06BX topical gel Within Guidelines

GE HEALTHCARE INC. MYOVIEW technetium Tc-99m tetrofosmin V09GA powder for injectable solution Within Guidelines 02172771 OMNISCAN - 287MG/ML gadodiamide V08CA injectable solution Within Guidelines 02241555 TESLASCAN - 37.9MG/ML mangafodipir trisodium V08CA injectable solution not sold No Current Sales

GENZYME CANADA INC. 02254506 ALDURAZYME - 0.58MG/ML laronidase A16AB injectable solution introduced (nas) Within Guidelines 02230694 CEREZYME - 200UNIT/VIAL imiglucerase A16AB powder for injectable solution Within Guidelines 02241751 CEREZYME - 400UNIT/VIAL imiglucerase A16AB powder for injectable solution Within Guidelines 02243790 HECTOROL - 2.5MCG/CAP doxercalciferol A11CC capsule Within Guidelines 02241701 RENAGEL - 403MG/CAP sevelamer hydrochloride V03AE capsule not sold No Current Sales 02244309 RENAGEL - 400MG/TAB sevelamer hydrochloride V03AE tablet not sold No Current Sales 02244310 RENAGEL - 800MG/TAB sevelamer hydrochloride V03AE tablet Within Guidelines 02246016 THYROGEN - 1.1MG/VIAL thyrotropin alfa V04CJ powder for injectable solution Within Guidelines

GILEAD SCIENCES INC. 02300699 ATRIPLA 600/200/300 efavirenz/emtricitabine/ J05AR tablet introduced Within Guidelines tenofovir disoproxil fumarate 02218046 DAUNOXOME - 50MG/VIAL daunorubicin, liposomal L01DB powder for injectable solution not sold No Current Sales 02272091 EMTRIVA - 200MG/CAP emtricitabine J05AF capsule introduced (nas) Within Guidelines 02247823 HEPSERA - 10MG/TAB adefovir dipivoxil J05AF tablet Within Guidelines 02274906 TRUVADA 200/300 emtricitabine/tenofovir disoproxil fumarate J05AR tablet Within Guidelines

02247128 VIREAD - 300MG/TAB tenofovir disoproxil fumarate J05AF tablet Within Guidelines www.pmprb-cepmb.gc.ca

January 1 — December 31, 2007 Annual Report 2007 13 DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status GLAXOSMITHKLINE CONSUMER HEALTHCARE INC. 02245677 ABREVA - 100MG/G docosanol D06BB topical cream Within Guidelines 01945092 SENSODYNE-F 5%/0.24% potassium nitrate/sodium fluoride A01AA gel toothpaste Within Guidelines 02083310 SENSODYNE-F 5%/0.24% potassium nitrate/sodium fluoride w/baking soda A01AA toothpaste not sold No Current Sales 02243131 SENSODYNE-F 5%/0.24% potassium nitrate/sodium fluoride A01AA toothpaste Within Guidelines 00624098 SENSODYNE-F 5%/0.8% potassium nitrate/sodium monofluorophosphate A01AA toothpaste not sold No Current Sales

GLAXOSMITHKLINE INC. 02192691 3TC - 10MG/ML lamivudine J05AF oral solution Within Guidelines 02192683 3TC - 150MG/TAB lamivudine J05AF tablet Within Guidelines 02247825 3TC - 300MG/TAB lamivudine J05AF tablet Within Guidelines 02245126 ADVAIR 25/125 salmeterol xinafoate/fluticasone propionate R03AK aerosol for inhalation Within Guidelines 02245127 ADVAIR 25/250 salmeterol xinafoate/fluticasone propionate R03AK aerosol for inhalation Within Guidelines 02245125 ADVAIR 25/50 salmeterol xinafoate/fluticasone propionate R03AK aerosol for inhalation not sold No Current Sales 02240835 ADVAIR 50/100 DISKUS salmeterol xinafoate/fluticasone propionate R03AK powder for inhalation Within Guidelines 02240836 ADVAIR 50/250 DISKUS salmeterol xinafoate/fluticasone propionate R03AK powder for inhalation Within Guidelines 02240837 ADVAIR 50/500 DISKUS salmeterol xinafoate/fluticasone propionate R03AK powder for inhalation Within Guidelines 02243541 AGENERASE - 50MG/CAP amprenavir J05AE capsule not sold No Current Sales 02243542 AGENERASE - 150MG/CAP amprenavir J05AE capsule Within Guidelines 02243543 AGENERASE - 15MG/ML amprenavir J05AE oral solution Within Guidelines 02087286 ALKERAN - 50MG/VIAL melphalan hydrochloride L01AA powder for injectable solution Within Guidelines 02237820 AMERGE - 1MG/TAB naratriptan hydrochloride N02CC tablet Within Guidelines 02237821 AMERGE - 2.5MG/TAB naratriptan hydrochloride N02CC tablet Within Guidelines 02245531 ARIXTRA - 2.5MG/SYRINGE fondaparinux sodium B01AX injectable solution expired Within Guidelines 01911937 AUGMENTIN 25/6.25 amoxicillin trihydrate/clavulanate potassium J01CR oral suspension not sold No Current Sales 01911953 AUGMENTIN 250/125 amoxicillin trihydrate/clavulanate potassium J01CR tablet not sold No Current Sales 01911945 AUGMENTIN 50/12.5 amoxicillin trihydrate/clavulanate potassium J01CR oral suspension not sold No Current Sales 01911961 AUGMENTIN 500/125 amoxicillin trihydrate/clavulanate potassium J01CR tablet not sold No Current Sales 02247085 AVANDAMET 1/500 rosiglitazone maleate/metformin hydrochloride A10BD tablet Within Guidelines 02248440 AVANDAMET 2/1000 rosiglitazone maleate/metformin hydrochloride A10BD tablet Within Guidelines 02247086 AVANDAMET 2/500 rosiglitazone maleate/metformin hydrochloride A10BD tablet Within Guidelines 02248441 AVANDAMET 4/1000 rosiglitazone maleate/metformin hydrochloride A10BD tablet Within Guidelines 02247087 AVANDAMET 4/500 rosiglitazone maleate/metformin hydrochloride A10BD tablet Within Guidelines 02258781 AVANDARYL 4/1 rosiglitazone maleate/glimepiride A10BD tablet Under Review 02258803 AVANDARYL 4/2 rosiglitazone maleate/glimepiride A10BD tablet Under Review 02258811 AVANDARYL 4/4 rosiglitazone maleate/glimepiride A10BD tablet Under Review 02241111 AVANDIA - 1MG/TAB rosiglitazone maleate A10BG tablet not sold No Current Sales 02241112 AVANDIA - 2MG/TAB rosiglitazone maleate A10BG tablet Within Guidelines 02241113 AVANDIA - 4MG/TAB rosiglitazone maleate A10BG tablet Within Guidelines 02241114 AVANDIA - 8MG/TAB rosiglitazone maleate A10BG tablet Within Guidelines 02247813 AVODART - 0.5MG/CAP dutasteride G04CB capsule Within Guidelines 00828521 BECLODISK - 0.1MG/DOSE beclomethasone dipropionate R03BA powder for inhalation expired No Current Sales 00828548 BECLODISK - 0.2MG/DOSE beclomethasone dipropionate R03BA powder for inhalation expired No Current Sales 01919490 CEFIZOX - 1000MG/VIAL ceftizoxime sodium J01DA powder for injectable solution not sold No Current Sales 01919504 CEFIZOX - 2000MG/VIAL ceftizoxime sodium J01DA powder for injectable solution not sold No Current Sales 01943049 CEFTIN - 25MG/ML cefuroxime axetil J01DA powder for oral suspension Subj. Investigation 02145286 CEFTIN - 250MG/POUCH cefuroxime axetil J01DA powfer for oral suspension not sold No Current Sales 00886882 CEFTIN - 125MG/TAB cefuroxime axetil J01DA tablet not sold No Current Sales 00886890 CEFTIN - 250MG/TAB cefuroxime axetil J01DA tablet Within Guidelines 00886904 CEFTIN - 500MG/TAB cefuroxime axetil J01DA tablet Within Guidelines www.pmprb-cepmb.gc.ca

14 Canadian Patentees and Patented Drug Products for Human Use DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status GLAXOSMITHKLINE INC. (continued) 01916882 CLAVULIN 25/6.25 amoxicillin trihydrate/clavulanate potassium J01CR oral suspension Within Guidelines 01916866 CLAVULIN 250/125 amoxicillin trihydrate/clavulanate potassium J01CR tablet Within Guidelines 02238831 CLAVULIN 40/5.7 amoxicillin trihydrate/clavulanate potassium J01CR oral suspension Within Guidelines 01916874 CLAVULIN 50/12.5 amoxicillin trihydrate/clavulanate potassium J01CR oral suspension Within Guidelines 01916858 CLAVULIN 500/125 amoxicillin trihydrate/clavulanate potassium J01CR tablet Within Guidelines 02238830 CLAVULIN 80/11.4 amoxicillin trihydrate/clavulanate potassium J01CR oral suspension Within Guidelines 02238829 CLAVULIN 875/125 amoxicillin trihydrate/clavulanate potassium J01CR tablet Within Guidelines 02239213 COMBIVIR 150/300 lamivudine/zidovudine J05AF tablet Within Guidelines 02229650 COREG - 3.125MG/TAB carvedilol C07AG tablet not sold No Current Sales 02229651 COREG - 6.25MG/TAB carvedilol C07AG tablet not sold No Current Sales 02229652 COREG - 12.5MG/TAB carvedilol C07AG tablet not sold No Current Sales 02229653 COREG - 25MG/TAB carvedilol C07AG tablet not sold No Current Sales 01919431 ENGERIX-B hepatitis B vaccine J07BC injectable suspension Subj. Investigation 02213583 FLOVENT - 0.025MG/DOSE fluticasone propionate R03BA aerosol for inhalation not sold No Current Sales 02213591 FLOVENT - 0.05MG/DOSE fluticasone propionate R03BA aerosol for inhalation not sold No Current Sales 02213621 FLOVENT - 0.05MG/DOSE fluticasone propionate R03BA powder for inhalation expired No Current Sales 02213648 FLOVENT - 0.1MG/DOSE fluticasone propionate R03BA powder for inhalation expired No Current Sales 02213605 FLOVENT - 0.125MG/DOSE fluticasone propionate R03BA aerosol for inhalation not sold No Current Sales 02213613 FLOVENT - 0.25MG/DOSE fluticasone propionate R03BA aerosol for inhalation not sold No Current Sales 02213656 FLOVENT - 0.25MG/DOSE fluticasone propionate R03BA powder for inhalation expired No Current Sales 02213664 FLOVENT - 0.5MG/DOSE fluticasone propionate R03BA powder for inhalation expired No Current Sales 02237244 FLOVENT DISKUS - 0.05MG/DOSE fluticasone propionate R03BA powder for inhalation Within Guidelines 02237245 FLOVENT DISKUS - 0.1MG/DOSE fluticasone propionate R03BA powder for inhalation Subj. Investigation 02237246 FLOVENT DISKUS - 0.25MG/DOSE fluticasone propionate R03BA powder for inhalation Within Guidelines 02237247 FLOVENT DISKUS - 0.5MG/DOSE fluticasone propionate R03BA powder for inhalation Within Guidelines 02244291 FLOVENT HFA - 0.05MG/DOSE fluticasone propionate R03BA aerosol for inhalation Within Guidelines 02244292 FLOVENT HFA - 0.125MG/DOSE fluticasone propionate R03BA aerosol for inhalation Within Guidelines 02244293 FLOVENT HFA - 0.25MG/DOSE fluticasone propionate R03BA aerosol for inhalation Within Guidelines 02187078 HAVRIX 1440 - 1440UNIT/ML hepatitis A vaccine (inactivated) J07BC injectable solution Subj. Investigation 02231056 HAVRIX 720 JUNIOR - 1440UNIT/ML hepatitis A vaccine (inactivated) J07BC injectable solution Subj. Investigation 02239194 HEPTOVIR - 5MG/ML lamivudine J05AF oral solution Within Guidelines 02239193 HEPTOVIR - 100MG/TAB lamivudine J05AF tablet Within Guidelines 02231116 HYCAMTIN - 4MG/VIAL topotecan hydrochloride L01XX powder for injectable solution Within Guidelines 02230418 IMITREX - 5MG/DOSE sumatriptan hemisulphate N02CC nasal spray Within Guidelines 02230419 IMITREX - 10MG/DOSE sumatriptan hemisulphate N02CC nasal spray not sold No Current Sales 02230420 IMITREX - 20MG/DOSE sumatriptan hemisulphate N02CC nasal spray Within Guidelines 02212188 IMITREX - 12MG/ML sumatriptan succinate N02CC injectable solution Within Guidelines 02239738 IMITREX DF - 25MG/TAB sumatriptan succinate N02CC tablet Within Guidelines 02212153 IMITREX DF - 50MG/TAB sumatriptan succinate N02CC tablet Within Guidelines 02212161 IMITREX DF - 100MG/TAB sumatriptan succinate N02CC tablet Within Guidelines 02230307 INFANRIX DaPT vaccine J07AJ injectable suspension not sold No Current Sales 02253852 INFANRIX-HEXA DaPT-IPV-hib-HEP.B vaccine J07CA injectable suspension not sold No Current Sales 02241482 INFANRIX-HIB DaPT-hib vaccine J07AG injectable suspension not sold No Current Sales 02241284 INFANRIX-IPV DaPT-IPV vaccine J07CA injectable suspension not sold No Current Sales 02257122 INFANRIX-IPV-HIB DaPT-IPV-hib vaccine J07CA injectable suspension not sold No Current Sales 02269341 KIVEXA 300/600 lamivudine/abacavir sulfate J05AF tablet Within Guidelines 02243803 LAMICTAL - 2MG/TAB lamotrigine N03AX chewable tcblet Within Guidelines 02240115 LAMICTAL - 5MG/TAB lamotrigine N03AX chewable tablet Within Guidelines 02142082 LAMICTAL - 25MG/TAB lamotrigine N03AX tablet Within Guidelines www.pmprb-cepmb.gc.ca

January 1 — December 31, 2007 Annual Report 2007 15 DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status GLAXOSMITHKLINE INC. (continued) 02240116 LAMICTAL - 25MG/TAB lamotrigine N03AX chewable tablet not sold No Current Sales 02142090 LAMICTAL - 50MG/TAB lamotrigine N03AX tablet not sold No Current Sales 02240117 LAMICTAL - 50MG/TAB lamotrigine N03AX chewable tablet not sold No Current Sales 02142104 LAMICTAL - 100MG/TAB lamotrigine N03AX tablet Within Guidelines 02240118 LAMICTAL - 100MG/TAB lamotrigine N03AX chewable tablet not sold No Current Sales 02142112 LAMICTAL - 150MG/TAB lamotrigine N03AX tablet Within Guidelines 02142120 LAMICTAL - 200MG/TAB lamotrigine N03AX tablet not sold No Current Sales 02240119 LAMICTAL - 200MG/TAB lamotrigine N03AX chewable tablet not sold No Current Sales 02142139 LAMICTAL - 250MG/TAB lamotrigine N03AX tablet not sold No Current Sales 02238151 MALARONE 250/100 atovaquone/proguanil hydrochloride P01BB tablet Within Guidelines 02264935 MALARONE 62.5/25 atovaquone/proguanil hydrochloride P01BB tablet Within Guidelines 02217422 MEPRON - 150MG/ML atovaquone P01AX oral suspension Within Guidelines 02009358 MEPRON - 250MG/TAB atovaquone P01AX tablet not sold No Current Sales 02245057 NEISVAC-C meningoccocal group c-tt conjugate vaccine, J07AH powder for injectable suspension No Current Sales adsorbed 02027887 PAXIL - 10MG/TAB paroxetine hydrochloride N06AB tablet Within Guidelines 01940481 PAXIL - 20MG/TAB paroxetine hydrochloride N06AB tablet Within Guidelines 01940473 PAXIL - 30MG/TAB paroxetine hydrochloride N06AB tablet Within Guidelines 02027895 PAXIL - 50MG/TAB paroxetine hydrochloride N06AB tablet not sold No Current Sales 02248503 PAXIL CR - 12.5MG/TAB paroxetine hydrochloride N06AB controlled-release tablet Subj. Investigation 02248504 PAXIL CR - 25MG/TAB paroxetine hydrochloride N06AB controlled-release tablet Within Guidelines 02267128 PAXIL CR - 37.5MG/TAB paroxetine hydrochloride N06AB controlled-release tablet not sold No Current Sales 02248029 PEDIARIX DaPT-IPV-HEP.B vaccine injectable suspension not sold No Current Sales 02239208 PRIORIX live, attenuated vaccine - measles/mumps/rubella J07BD injectable suspension Subj. Investigation 02231831 PYLORID - 400MG/TAB ranitidine bismuth citrate A02BA tablet not sold No Current Sales 02237735 RAXAR - 200MG/TAB grepafloxacin hydrochloride J01MA tablet not sold No Current Sales 02240863 RELENZA - 5MG/DOSE zanamivir J05AH powder for inhalation Subj. Investigation 02232565 REQUIP - 0.25MG/TAB ropinirole hydrochloride N04BC tablet Within Guidelines 02232566 REQUIP - 0.5MG/TAB ropinirole hydrochloride N04BC tablet not sold No Current Sales 02232567 REQUIP - 1MG/TAB ropinirole hydrochloride N04BC tablet Within Guidelines 02232568 REQUIP - 2MG/TAB ropinirole hydrochloride N04BC tablet Within Guidelines 02240542 REQUIP - 3MG/TAB ropinirole hydrochloride N04BC tablet not sold No Current Sales 02240543 REQUIP - 4MG/TAB ropinirole hydrochloride N04BC tablet not sold No Current Sales 02232569 REQUIP - 5MG/TAB ropinirole hydrochloride N04BC tablet Within Guidelines 01902660 RETROVIR - 100MG/CAP zidovudine J05AF capsule Within Guidelines 01902644 RETROVIR - 10MG/ML zidovudine J05AF injectable solution Subj. Investigation 01902652 RETROVIR - 10MG/ML zidovudine J05AF syrup Within Guidelines 02238699 RETROVIR - 300MG/TAB zidovudine J05AF tablet not sold No Current Sales 02211742 SEREVENT - 0.025MG/DOSE salmeterol xinafoate R03AC aerosol for inhalation not sold No Current Sales 02214261 SEREVENT DISKHALER - 0.05MG/DOSE salmeterol xinafoate R03AC powder for inhalation Within Guidelines 02231129 SEREVENT DISKUS - 0.05MG/DOSE salmeterol xinafoate R03AC powder for inhalation Within Guidelines 01927280 TAGAMET - 6MG/ML cimetidine hydrochloride A02BA injectable solution not sold No Current Sales 01916750 TAGAMET - 60MG/ML cimetidine hydrochloride A02BA oral solution not sold No Current Sales 01916807 TAGAMET - 150MG/ML cimetidine hydrochloride A02BA injectable solution not sold No Current Sales 01916793 TAGAMET - 200MG/TAB cimetidine A02BA tablet not sold No Current Sales 01916815 TAGAMET - 300MG/TAB cimetidine A02BA tablet not sold No Current Sales 01916785 TAGAMET - 400MG/TAB cimetidine A02BA tablet not sold No Current Sales 01916777 TAGAMET - 600MG/TAB cimetidine A02BA tablet not sold No Current Sales 01916769 TAGAMET - 800MG/TAB cimetidine A02BA tablet not sold No Current Sales 02261553 TELZIR - 50MG/ML fosamprenavir calcium J05AE oral suspension Within Guidelines 02261545 TELZIR - 700MG/TAB fosamprenavir calcium J05AE tablet Subj. Investigation www.pmprb-cepmb.gc.ca

16 Canadian Patentees and Patented Drug Products for Human Use DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status GLAXOSMITHKLINE INC. (continued) 01916939 TIMENTIN 3000/100 ticarcillin disodium/clavulanate potassium J01CR powder for injectable solution Within Guidelines 02247880 TIMENTIN 30000/1000 ticarcillin disodium/clavulanate potassium J01CR powder for injectable solution Within Guidelines 02244757 TRIZIVIR 150/300/300 lamivudine/zidovudine/abacavir sulfate J05AF tablet Within Guidelines 02230578 TWINRIX 720/20 combined hepatitis A & B vaccine J07BC injectable suspension Subj. Investigation 02237548 TWINRIX JUNIOR 360/10 combined hepatitis A & B vaccine J07BC injectable suspension Subj. Investigation 02239130 VALTREX - 250MG/TAB valacyclovir hydrochloride J05AB tablet not sold No Current Sales 02219492 VALTREX - 500MG/TAB valacyclovir hydrochloride J05AB tablet Within Guidelines 02246559 VALTREX - 1000MG/TAB valacyclovir hydrochloride J05AB tablet Within Guidelines 02214997 VENTODISK - 0.2MG/DOSE salbutamol sulfate R03AC powder for inhalation expired Within Guidelines 02215004 VENTODISK - 0.4MG/DOSE salbutamol sulfate R03AC powder for inhalation expired Subj. Investigation 02213478 VENTOLIN - 0.1MG/DOSE salbutamol sulfate R03AC aerosol for inhalation not sold No Current Sales 02243115 VENTOLIN DISKUS - 0.2MG/DOSE salbutamol sulfate R03AC powder for inhalation Subj. Investigation 02241497 VENTOLIN HFA - 0.1MG/DOSE salbutamol sulfate R03AC aerosol for inhalation Within Guidelines 02212374 ZANTAC - 15MG/ML ranitidine hydrochloride A02BA oral solution Within Guidelines 02212366 ZANTAC - 25MG/ML ranitidine hydrochloride A02BA injectable solution Subj. Investigation 02212331 ZANTAC - 150MG/TAB ranitidine hydrochloride A02BA tablet Within Guidelines 02212358 ZANTAC - 300MG/TAB ranitidine hydrochloride A02BA tablet Within Guidelines 00849421 ZANTAC C - 150MG/CAP ranitidine hydrochloride A02BA capsule not sold No Current Sales 00849448 ZANTAC C - 300MG/CAP ranitidine hydrochloride A02BA capsule not sold No Current Sales 01951831 ZANTAC EFFERVESCENT - 150MG/POUCH ranitidine hydrochloride A02BA effervescent granules not sold No Current Sales 01951823 ZANTAC EFFERVESCENT - 300MG/POUCH ranitidine hydrochloride A02BA effervescent granules not sold No Current Sales 02076284 ZANTAC EFFERVESCENT - 150MG/TAB ranitidine hydrochloride A02BA effervescent tablet not sold No Current Sales 02076292 ZANTAC EFFERVESCENT - 300MG/TAB ranitidine hydrochloride A02BA effervescent tablet not sold No Current Sales 02240358 ZIAGEN - 20MG/ML abacavir sulfate J05AF oral solution Within Guidelines 02240357 ZIAGEN - 300MG/TAB abacavir sulfate J05AF tablet Within Guidelines 02229639 ZOFRAN - 0.8MG/ML ondansetron hydrochloride A04AA oral solution Within Guidelines 01911821 ZOFRAN - 2MG/ML ondansetron hydrochloride A04AA injectable solution Within Guidelines 02213567 ZOFRAN - 4MG/TAB ondansetron hydrochloride A04AA tablet Within Guidelines 02213575 ZOFRAN - 8MG/TAB ondansetron hydrochloride A04AA tablet Within Guidelines 02239372 ZOFRAN ODT - 4MG/TAB ondansetron hydrochloride A04AA orally disintegrating tablet Within Guidelines 02239373 ZOFRAN ODT - 8MG/TAB ondansetron hydrochloride A04AA orally disintegrating tablet Subj. Investigation 00634506 ZOVIRAX - 200MG/TAB acyclovir J05AB tablet Within Guidelines 01911627 ZOVIRAX - 400MG/TAB acyclovir J05AB tablet Within Guidelines 01911635 ZOVIRAX - 800MG/TAB acyclovir J05AB tablet Within Guidelines

GRACEWAY PHARMACEUTICALS 02232570 AIROMIR - 0.1MG/DOSE salbutamol sulfate R03AC aerosol for inhalation Subj. Investigation 02239505 ALDARA - 250MG/POUCH imiquimod D06BB topical cream Within Guidelines 02242030 QVAR - 0.1MG/DOSE beclomethasone dipropionate R03BA aerosol for inhalation Within Guidelines 02162806 MINITRAN 0.2 - 18MG/PATCH nitroglycerin C01DA transdermal patch expired Within Guidelines 02163527 MINITRAN 0.4 - 36MG/PATCH nitroglycerin C01DA transdermal patch expired Within Guidelines 02163535 MINITRAN 0.6 - 54MG/PATCH nitroglycerin C01DA transdermal patch expired Within Guidelines 02164337 MINITRAN 0.8 - 72MG/PATCH nitroglycerin C01DA transdermal patch expired No Current Sales 02125226 NIDAGEL - 7.5MG/G metronidazole G01AF vaginal gel Within Guidelines 02242029 QVAR - 0.05MG/DOSE beclomethasone dipropionate R03BA aerosol for inhalation Within Guidelines

GRIFOLS BIOLOGICALS INC. ALBUTEIN - 50MG/ML albumin B05AA injectable solution not sold No Current Sales ALBUTEIN - 250MG/ML albumin B05AA injectable solution not sold No Current Sales ALPHANINE SD - 1UNIT/DOSE factor IX (human) B02BD injectable solution not sold No Current Sales www.pmprb-cepmb.gc.ca

January 1 — December 31, 2007 Annual Report 2007 17 DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status HOFFMANN-LA ROCHE LIMITED 02225689 ACTIVASE - 50MG/VIAL alteplase B01AD powder for injectable solution Within Guidelines 02147440 ACTIVASE - 100MG/VIAL alteplase B01AD powder for injectable solution Within Guidelines 02270994 AVASTIN - 25MG/ML bevacizumab L01XC injectable solution Within Guidelines 02232770 BONDRONAT - 1MG/ML ibandronate sodium M05BA injectable solution not sold No Current Sales 02250136 BONVIVA - 2.5MG/TAB ibandronate sodium M05BA tablet not sold No Current Sales 02034514 CARDENE SR - 30MG/CAP nicardipine hydrochloride C08CA sustained-release capsule not sold No Current Sales 01950657 CARDENE SR - 45MG/CAP nicardipine hydrochloride C08CA sustained-release capsule not sold No Current Sales 01950649 CARDENE SR - 60MG/CAP nicardipine hydrochloride C08CA sustained-release capsule not sold No Current Sales 02245859 CATHFLO - 2MG/VIAL alteplase B01AD powder for injectable solution Within Guidelines 02192748 CELLCEPT - 250MG/CAP mycophenolate mofetil L04AA capsule Within Guidelines 02242145 CELLCEPT - 200MG/ML mycophenolate mofetil L04AA powder for oral suspension Within Guidelines 02237484 CELLCEPT - 500MG/TAB mycophenolate mofetil L04AA tablet Within Guidelines 02240347 CELLCEPT - 500MG/VIAL mycophenolate mofetil L04AA powder for injectable solution Within Guidelines 02186802 CYTOVENE - 250MG/CAP ganciclovir J05AB capsule not sold No Current Sales 02240362 CYTOVENE - 500MG/CAP ganciclovir J05AB capsule not sold No Current Sales 02162695 CYTOVENE - 500MG/VIAL ganciclovir sodium J05AB powder for injectable solution Within Guidelines 02129094 DEMADEX - 10MG/ML torsemide C03CA injectable solution not sold No Current Sales 02129000 DEMADEX - 5MG/TAB torsemide C03CA tablet not sold No Current Sales 02129019 DEMADEX - 10MG/TAB torsemide C03CA tablet not sold No Current Sales 02129027 DEMADEX - 20MG/TAB torsemide C03CA tablet not sold No Current Sales 02129035 DEMADEX - 100MG/TAB torsemide C03CA tablet not sold No Current Sales 02239083 FORTOVASE - 200MG/CAP saquinavir J05AE capsule not sold No Current Sales 02247725 FUZEON - 108MG/VIAL enfuvirtide J05AX powder for injectable solution Within Guidelines 02240692 HERCEPTIN - 440MG/VIAL trastuzumab L01XC powder for injectable solution Within Guidelines 01990918 HIVID - 0.375MG/TAB zalcitabine J05AF tablet not sold No Current Sales 01990896 HIVID - 0.75MG/TAB zalcitabine J05AF tablet not sold No Current Sales 02216965 INVIRASE - 200MG/CAP saquinavir mesylate J05AE capsule Within Guidelines 02279320 INVIRASE - 500MG/TAB saquinavir mesylate J05AE tablet Within Guidelines 02185881 KYTRIL - 1MG/TAB granisetron hydrochloride A04AA tablet Subj. Investigation 02237672 KYTRIL - 2MG/TAB granisetron hydrochloride A04AA tablet not sold No Current Sales 02088371 KYTRIL INJECTION - 1MG/ML granisetron hydrochloride A04AA injectable solution Within Guidelines 00899348 MANERIX - 100MG/TAB moclobemide N06AG tablet not sold No Current Sales 00899356 MANERIX - 150MG/TAB moclobemide N06AG tablet Within Guidelines 02166747 MANERIX - 300MG/TAB moclobemide N06AG tablet Within Guidelines 02216183 NUTROPIN - 5MG/VIAL somatropin H01AC powder for injectable solution Within Guidelines 02216191 NUTROPIN - 10MG/VIAL somatropin H01AC powder for injectable solution Within Guidelines 02229722 NUTROPIN AQ - 5MG/ML somatropin H01AC injectable solution Within Guidelines 02249002 NUTROPIN AQ PEN - 5MG/ML somatropin H01AC injectable solution Within Guidelines 01927078 OSTAC - 400MG/CAP clodronate disodium M05BA capsule not sold No Current Sales 02248077 PEGASYS - 180MCG/SYRINGE peginterferon alfa-2a L03AB injectable solution Subj. Investigation 02248078 PEGASYS - 180MCG/VIAL peginterferon alfa-2a L03AB injectable solution Within Guidelines 02253410 PEGASYS RBV peginterferon alfa-2a + ribavirin J05AB injectable solution + tablet Within Guidelines 02253429 PEGASYS RBV peginterferon alfa-2a + ribavirin J05AB injectable solution + tablet Within Guidelines 02204584 PROTROPIN - 5MG/VIAL somatrem H01AC powder for injectable solution not sold No Current Sales 02204576 PROTROPIN - 10MG/VIAL somatrem H01AC powder for injectable solution not sold No Current Sales 02046733 PULMOZYME - 2.5MG/AMPOULE dornase alfa R05CB solution for inhalation Within Guidelines 02241927 RITUXAN - 10MG/ML rituximab L01XC injectable solution Within Guidelines 00481823 ROCALTROL - 0.00025MG/CAP calcitriol A11CC capsule Within Guidelines 00481815 ROCALTROL - 0.0005MG/CAP calcitriol A11CC capsule Within Guidelines 00824291 ROCALTROL - 0.001MG/ML calcitriol A11CC oral solution Within Guidelines 01911988 ROFERON-A - 3000000UNIT/VIAL interferon alfa-2a L03AB powder for injectable solution not sold No Current Sales www.pmprb-cepmb.gc.ca

18 Canadian Patentees and Patented Drug Products for Human Use DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status HOFFMANN-LA ROCHE LIMITED (continued) 02217015 ROFERON-A - 3000000UNIT/VIAL interferon alfa-2a L03AB injectable solution not sold No Current Sales 02217023 ROFERON-A - 4500000UNIT/VIAL interferon alfa-2a L03AB injectable solution not sold No Current Sales 02217031 ROFERON-A - 6000000UNIT/VIAL interferon alfa-2a L03AB injectable solution not sold No Current Sales 01911996 ROFERON-A - 9000000UNIT/VIAL interferon alfa-2a L03AB powder for injectable solution not sold No Current Sales 02217058 ROFERON-A - 9000000UNIT/VIAL interferon alfa-2a L03AB injectable solution not sold Subj. Investigation 00812471 ROFERON-A - 18000000UNIT/VIAL interferon alfa-2a L03AB powder for injectable solution not sold No Current Sales 01912003 ROFERON-A - 18000000UNIT/VIAL interferon alfa-2a L03AB powder for injectable solution not sold Subj. Investigation 02217066 ROFERON-A - 18000000UNIT/VIAL interferon alfa-2a L03AB injectable solution not sold No Current Sales 00891002 ROFERON-A - 36000000UNIT/VIAL interferon alfa-2a L03AB injectable solution not sold No Current Sales 02241472 TAMIFLU - 75MG/CAP oseltamivir phosphate J05AH capsule Within Guidelines 02245549 TAMIFLU - 12MG/ML oseltamivir phosphate J05AH powder for oral suspension not sold No Current Sales 02269007 TARCEVA - 25MG/TAB erlotinib hydrochloride L01XX tablet introduced Within Guidelines 02269015 TARCEVA - 100MG/TAB erlotinib hydrochloride L01XX tablet Within Guidelines 02269023 TARCEVA - 150MG/TAB erlotinib hydrochloride L01XX tablet Within Guidelines 02235914 TASMAR - 100MG/TAB tolcapone N04BX tablet not sold No Current Sales 02235921 TASMAR - 200MG/TAB tolcapone N04BX tablet not sold No Current Sales 01911767 TICLID - 125MG/TAB ticlopidine hydrochloride B01AC tablet not sold No Current Sales 02162776 TICLID - 250MG/TAB ticlopidine hydrochloride B01AC tablet not sold No Current Sales 02244826 TNKASE - 50MG/VIAL tenecteplase B01AD powder for injectable solution Subj. Investigation 02162660 TORADOL - 10MG/TAB ketorolac tromethamine M01AB tablet Within Guidelines 02162644 TORADOL IM - 10MG/ML ketorolac tromethamine M01AB injectable solution Within Guidelines 02162652 TORADOL IM - 30MG/ML ketorolac tromethamine M01AB injectable solution Subj. Investigation 02245777 VALCYTE - 450MG/TAB valganciclovir hydrochloride J05AB tablet Within Guidelines 02238453 XELODA - 150MG/TAB capecitabine L01BC tablet Within Guidelines 02238454 XELODA - 500MG/TAB capecitabine L01BC tablet Within Guidelines 02240325 XENICAL - 120MG/CAP orlistat A08AB capsule Within Guidelines 02241473 ZENAPAX - 5MG/ML daclizumab L04AA injectable solution Within Guidelines

HOSPIRA HEALTHCARE CORPORATION (CANADA) 02246024 HEXTEND - 60MG/ML hetastarch B05AA injectable solution VCU

INO THERAPEUTICS INC. 02270838 INOMAX 100 PPM nitric oxide R07AX gas for inhalation not sold No Current Sales 02270846 INOMAX 800 PPM nitric oxide R07AX gas for inhalation Within Guidelines

IROKO INTERNATIONAL LP 00800430 VANCOCIN - 125MG/CAP vancomycin hydrochloride J01XA capsule Within Guidelines 00788716 VANCOCIN - 250MG/CAP vancomycin hydrochloride J01XA capsule Within Guidelines

JANSSEN-ORTHO INC. 02247732 CONCERTA - 18MG/TAB methylphenidate hydrochloride N06BA extended-release tablet Notice of Hearing 02250241 CONCERTA - 27MG/TAB methylphenidate hydrochloride N06BA extended-release tablet Notice of Hearing 02247733 CONCERTA - 36MG/TAB methylphenidate hydrochloride N06BA extended-release tablet Notice of Hearing 02247734 CONCERTA - 54MG/TAB methylphenidate hydrochloride N06BA extended-release tablet Notice of Hearing 02243960 DITROPAN XL - 5MG/TAB oxybutynin chloride G04BD extended-release tablet Within Guidelines 02243961 DITROPAN XL - 10MG/TAB oxybutynin chloride G04BD extended-release tablet Within Guidelines 02259117 DITROPAN XL - 15MG/TAB oxybutynin chloride G04BD extended-release tablet not sold No Current Sales 02126575 EPREX - 2000UNIT/ML epoetin alfa B03XA injectable solution not sold No Current Sales 02126583 EPREX - 4000UNIT/ML epoetin alfa B03XA injectable solution not sold No Current Sales 02126591 EPREX - 10000UNIT/ML epoetin alfa B03XA injectable solution not sold No Current Sales

02206072 EPREX - 20000UNIT/ML epoetin alfa B03XA injectable solution Within Guidelines www.pmprb-cepmb.gc.ca

January 1 — December 31, 2007 Annual Report 2007 19 DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status JANSSEN-ORTHO INC. (continued) 02231583 EPREX - 1000UNIT/SYRINGE epoetin alfa B03XA injectable solution Within Guidelines 02231584 EPREX - 2000UNIT/SYRINGE epoetin alfa B03XA injectable solution Within Guidelines 02231585 EPREX - 3000UNIT/SYRINGE epoetin alfa B03XA injectable solution Within Guidelines 02231586 EPREX - 4000UNIT/SYRINGE epoetin alfa B03XA injectable solution Within Guidelines 02243400 EPREX - 5000UNIT/SYRINGE epoetin alfa B03XA injectable solution Within Guidelines 02243401 EPREX - 6000UNIT/SYRINGE epoetin alfa B03XA injectable solution Within Guidelines 02243402 EPREX - 7000UNIT/SYRINGE epoetin alfa B03XA injectable solution not sold No Current Sales 02243403 EPREX - 8000UNIT/SYRINGE epoetin alfa B03XA injectable solution Within Guidelines 02243404 EPREX - 9000UNIT/SYRINGE epoetin alfa B03XA injectable solution not sold No Current Sales 02231587 EPREX - 10000UNIT/SYRINGE epoetin alfa B03XA injectable solution Within Guidelines 02243239 EPREX - 20000UNIT/SYRINGE epoetin alfa B03XA injectable solution Within Guidelines 02288680 EPREX - 30000UNIT/SYRINGE epoetin alfa B03XA injectable solution introduced Subj. Investigation 02240722 EPREX - 40000UNIT/SYRINGE epoetin alfa B03XA injectable solution Within Guidelines 02248297 EVRA 150/20 norelgestromin/ethinyl estradiol G03AA transdermal patch Within Guidelines 02300273 INVEGA - 3MG/TAB paliperidone N05AX extended-release tablet introduced (nas) Under Review 02300281 INVEGA - 6MG/TAB paliperidone N05AX extended-release tablet introduced (nas) Under Review 02300303 INVEGA - 9MG/TAB paliperidone N05AX extended-release tablet introduced (nas) Under Review 02022117 LEUSTATIN - 1MG/ML cladribine L01BB injectable solution Within Guidelines 02236839 LEVAQUIN - 5MG/ML levofloxacin J01MA injectable solution Within Guidelines 02236840 LEVAQUIN - 25MG/ML levofloxacin J01MA injectable solution not sold No Current Sales 02236841 LEVAQUIN - 250MG/TAB levofloxacin J01MA tablet Subj. Investigation 02236842 LEVAQUIN - 500MG/TAB levofloxacin J01MA tablet Subj. Investigation 02246804 LEVAQUIN - 750MG/TAB levofloxacin J01MA tablet Subj. Investigation 02301393 NATRECOR - 1.5MG/VIAL nesiritide C01DX powder for injectable solution not sold No Current Sales 02243796 PARIET - 10MG/TAB rabeprazole sodium A02BC tablet Within Guidelines 02243797 PARIET - 20MG/TAB rabeprazole sodium A02BC tablet Within Guidelines 02247906 PREFESTA 1+1/.09 estradiol 17ß + estradiol 17ß/norgestimate tablet not sold No Current Sales 02241510 PREPULSID - 5MG/TAB cisapride tartrate A03FA tablet not sold No Current Sales 02241511 PREPULSID - 10MG/TAB cisapride tartrate A03FA tablet not sold No Current Sales 02241512 PREPULSID - 20MG/TAB cisapride tartrate A03FA tablet not sold No Current Sales 02236435 PREPULSID QS - 5MG/TAB cisapride monohydrate A03FA tablet not sold No Current Sales 02236441 PREPULSID QS - 10MG/TAB cisapride monohydrate A03FA tablet not sold No Current Sales 02236443 PREPULSID QS - 20MG/TAB cisapride monohydrate A03FA tablet not sold No Current Sales 02284057 PREZISTA - 300MG/TAB darunavir ethanolate J05AE tablet Within Guidelines 02239405 REGRANEX - 0.1MG/G becaplermin D03AX topical gel Within Guidelines 02244302 REMINYL - 4MG/ML galantamine hydrobromide N06DA oral solution not sold No Current Sales 02244298 REMINYL - 4MG/TAB galantamine hydrobromide N06DA tablet not sold No Current Sales 02244299 REMINYL - 8MG/TAB galantamine hydrobromide N06DA tablet not sold No Current Sales 02244300 REMINYL - 12MG/TAB galantamine hydrobromide N06DA tablet not sold No Current Sales 02266717 REMINYL ER - 8MG/CAP galantamine hydrobromide N06DA extended-release capsule Within Guidelines 02266725 REMINYL ER - 16MG/CAP galantamine hydrobromide N06DA extended-release capsule Within Guidelines 02266733 REMINYL ER - 24MG/CAP galantamine hydrobromide N06DA extended-release capsule Within Guidelines 02236950 RISPERDAL - 1MG/ML risperidone N05AX oral solution not sold No Current Sales 02298465 RISPERDAL CONSTA - 12.5MG/VIAL risperidone N05AX powder for injectable suspension not sold No Current Sales 02255707 RISPERDAL CONSTA - 25MG/VIAL risperidone N05AX powder for injectable suspension VCU 02255723 RISPERDAL CONSTA - 37.5MG/VIAL risperidone N05AX powder for injectable suspension VCU 02255758 RISPERDAL CONSTA - 50MG/VIAL risperidone N05AX powder for injectable suspension VCU 02255715 RISPERDAL CONSTA 3N - 25MG/VIAL risperidone N05AX powder for injectable suspension not sold No Current Sales 02255731 RISPERDAL CONSTA 3N - 37.5MG/VIAL risperidone N05AX powder for injectable suspension not sold No Current Sales 02255766 RISPERDAL CONSTA 3N - 50MG/VIAL risperidone N05AX powder for injectable suspension not sold No Current Sales 02247704 RISPERDAL M-TAB - 0.5MG/TAB risperidone N05AX orally disintegrating tablet Within Guidelines www.pmprb-cepmb.gc.ca

20 Canadian Patentees and Patented Drug Products for Human Use DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status JANSSEN-ORTHO INC. (continued) 02247705 RISPERDAL M-TAB - 1MG/TAB risperidone N05AX orally disintegrating tablet Within Guidelines 02247706 RISPERDAL M-TAB - 2MG/TAB risperidone N05AX orally disintegrating tablet Within Guidelines 02268086 RISPERDAL M-TAB - 3MG/TAB risperidone N05AX orally disintegrating tablet Within Guidelines 02268094 RISPERDAL M-TAB - 4MG/TAB risperidone N05AX orally disintegrating tablet Within Guidelines 02047454 SPORANOX - 100MG/CAP itraconazole J02AC capsule Within Guidelines 02231347 SPORANOX - 10MG/ML itraconazole J02AC oral solution Subj. Investigation 02243343 SPORANOX - 10MG/ML itraconazole J02AC injectable solution not sold No Current Sales 02239907 TOPAMAX - 15MG/CAP topiramate N03AX capsule sprinkle Within Guidelines 02239908 TOPAMAX - 25MG/CAP topiramate N03AX capsule sprinkle Within Guidelines 02239909 TOPAMAX - 50MG/CAP topiramate N03AX capsule sprinkle not sold No Current Sales 02230893 TOPAMAX - 25MG/TAB topiramate N03AX tablet Within Guidelines 02231385 TOPAMAX - 50MG/TAB topiramate N03AX tablet not sold No Current Sales 02230894 TOPAMAX - 100MG/TAB topiramate N03AX tablet Within Guidelines 02230896 TOPAMAX - 200MG/TAB topiramate N03AX tablet Within Guidelines 02231386 TOPAMAX - 300MG/TAB topiramate N03AX tablet not sold No Current Sales 02231387 TOPAMAX - 400MG/TAB topiramate N03AX tablet not sold No Current Sales 02264846 TRAMACET 37.5/325 tramadol hydrochloride/acetaminophen N02AX tablet Within Guidelines 02258560 TRI-CYCLEN LO .18-.215-.25/.0 norgestimate/ethinyl estradiol G03AA tablet Within Guidelines 02258587 TRI-CYCLEN LO .18-.215-.25/.0 norgestimate/ethinyl estradiol G03AA tablet Within Guidelines 02262452 VELCADE - 3.5MG/VIAL bortezomib L01XX powder for injectable solution Subj. Investigation

JOHNSON & JOHNSON INC. 02182920 NIZORAL - 20MG/ML ketoconazole D01AC shampoo Within Guidelines 02052407 RENOVA - 0.5MG/G tretinoin D10AD cream not sold No Current Sales 02264633 RETIN-A MICRO - 0.4MG/G tretinoin D10AD topical gel Within Guidelines 02243914 RETIN-A MICRO - 1MG/G tretinoin D10AD topical gel Within Guidelines

JOHNSON & JOHNSON-MERCK 02185911 PEPCID AC - 10MG/TAB famotidine A02BA chewable tablet Within Guidelines 02185938 PEPCID AC - 10MG/TAB famotidine A02BA tablet Within Guidelines 02243053 PEPCID COMPLETE famotidine/calcium carbonate/magnesium A02BA chewable tablet Within Guidelines hydroxide

LEO PHARMA INC. 02244126 DOVOBET calcipotriol/betamethasone dipropionate D05AX topical ointment VCU 01976133 DOVONEX - 0.05MG/G calcipotriol D05AX topical ointment Within Guidelines 02150956 DOVONEX - 0.05MG/G calcipotriol D05AX topical cream Within Guidelines 02194341 DOVONEX - 0.05MG/ML calcipotriol D05AX scalp lotion Within Guidelines 02243861 FUCITHALMIC - 10MG/G fusidic acid S01AA ophthalmic drops expired No Current Sales 02243862 FUCITHALMIC - 10MG/G fusidic acid S01AA ophthalmic drops expired No Current Sales 02167840 INNOHEP - 10000UNIT/ML tinzaparin sodium B01AB injectable suspension Subj. Investigation 02229755 INNOHEP - 10000UNIT/ML tinzaparin sodium B01AB injectable suspension Subj. Investigation 02167859 INNOHEP - 11700UNIT/ML tinzaparin sodium B01AB injectable suspension not sold No Current Sales 02229515 INNOHEP - 20000UNIT/ML tinzaparin sodium B01AB injectable suspension Within Guidelines 02231478 INNOHEP - 20000UNIT/ML tinzaparin sodium B01AB injectable suspension Within Guidelines

LUNDBECK CANADA INC. 02239606 CELEXA - 10MG/TAB citalopram hydrobromide N06AB tablet not sold No Current Sales 02239607 CELEXA - 20MG/TAB citalopram hydrobromide N06AB tablet Within Guidelines 02239608 CELEXA - 40MG/TAB citalopram hydrobromide N06AB tablet Within Guidelines 02263211 CIPRALEX - 5MG/TAB escitalopram oxalate N06AB tablet not sold No Current Sales www.pmprb-cepmb.gc.ca

January 1 — December 31, 2007 Annual Report 2007 21 DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status LUNDBECK CANADA INC. (continued) 02263238 CIPRALEX - 10MG/TAB escitalopram oxalate N06AB tablet Within Guidelines 02263246 CIPRALEX - 15MG/TAB escitalopram oxalate N06AB tablet not sold No Current Sales 02263254 CIPRALEX - 20MG/TAB escitalopram oxalate N06AB tablet Within Guidelines 02260638 EBIXA - 10MG/TAB memantine hydrochloride N06DX tablet Within Guidelines 02247027 KEPPRA - 250MG/TAB levetiracetam N03AX tablet Within Guidelines 02247028 KEPPRA - 500MG/TAB levetiracetam N03AX tablet Within Guidelines 02247029 KEPPRA - 750MG/TAB levetiracetam N03AX tablet Within Guidelines

MAYNE PHARMA (CANADA) INC. ONCOSCINT CR/OV - 1MG/KIT satumomab pendetide V09IB injectable solution not sold No Current Sales

MCNEIL CONSUMER HEALTHCARE 02248128 AXERT - 6.25MG/TAB almotriptan malate N02CC tablet Within Guidelines 02248129 AXERT - 12.5MG/TAB almotriptan malate N02CC tablet Within Guidelines 02242365 CHILDREN MOTRIN - 20MG/ML ibuprofen M01AE oral suspension Subj. Investigation 02238626 CHILDREN MOTRIN - 40MG/ML ibuprofen M01AE oral suspension Subj. Investigation 02243178 CHILDREN MOTRIN - 50MG/TAB ibuprofen M01AE chewable tablet not sold No Current Sales 02247343 CHILDREN MOTRIN - 50MG/TAB ibuprofen M01AE chewable tablet not sold Subj. Investigation 02243179 CHILDREN MOTRIN JUNIOR - 100MG/TAB ibuprofen M01AE chewable tablet not sold No Current Sales 02247344 CHILDREN MOTRIN JUNIOR - 100MG/TAB ibuprofen M01AE chewable tablet Subj. Investigation 02237297 IMODIUM ADVANCED 2/125 loperamide hydrochloride/simethicone A07DA chewable tablet Subj. Investigation 02245185 IMODIUM ADVANCED CAPLET 2/125 loperamide hydrochloride/simethicone A07DA caplet Subj. Investigation 02230542 IMODIUM QUICK DISSOLVE - 2MG/TAB loperamide hydrochloride A07DA tablet Subj. Investigation 02132575 MEDIPREN - 20MG/ML ibuprofen M01AE oral suspension not sold No Current Sales 02093138 NICODERM 14 - 78MG/PATCH nicotine N07BA transdermal patch Notice of Hearing 02093146 NICODERM 21 - 114MG/PATCH nicotine N07BA transdermal patch Notice of Hearing 02093111 NICODERM 7 - 36MG/PATCH nicotine N07BA transdermal patch Notice of Hearing 02241742 NICORETTE INHALER - 10MG/DOSE nicotine N07BA cartridge for inhalation Within Guidelines 02246162 REACTINE ALLERGY & SINUS 5/12 cetirizine hydrochloride/pseudoephedrine R01BA extended-release tablet Subj. Investigation hydrochloride 02246060 TYLENOL 8 HOUR - 650MG/CPL acetaminophen N02BE sustained-release caplet Subj. Investigation 02238885 TYLENOL ARTHRITIS PAIN - 650MG/CPL acetaminophen N02BE sustained-release caplet Subj. Investigation 02277301 ZANTAC 150 - 150MG/TAB ranitidine hydrochloride A02BA tablet introduced Subj. Investigation 02230287 ZANTAC 75 - 75MG/TAB ranitidine hydrochloride A02BA tablet Subj. Investigation

MERCK FROSST CANADA LTD. 02240706 AGGRASTAT - 0.05MG/ML tirofiban hydrochloride B01AC injectable solution Within Guidelines 02240705 AGGRASTAT - 0.25MG/ML tirofiban hydrochloride B01AC injectable solution not sold No Current Sales 02244265 CANCIDAS - 50MG/VIAL caspofungin acetate J02AX powder for injectable solution Within Guidelines 02244266 CANCIDAS - 70MG/VIAL caspofungin acetate J02AX powder for injectable solution Within Guidelines 02240113 COSOPT 20/5 dorzolamide hydrochloride/tiomolol maleate S01ED ophthalmic solution Within Guidelines 02258692 COSOPT 20/5 PF dorzolamide hydrochloride/tiomolol maleate S01ED ophthalmic solution Within Guidelines 02182815 COZAAR - 25MG/TAB losartan potassium C09CA tablet Within Guidelines 02182874 COZAAR - 50MG/TAB losartan potassium C09CA tablet Within Guidelines 02182882 COZAAR - 100MG/TAB losartan potassium C09CA tablet Within Guidelines 02229153 CRIXIVAN - 100MG/CAP indinavir sulfate J05AE capsule not sold No Current Sales 02229161 CRIXIVAN - 200MG/CAP indinavir sulfate J05AE capsule Within Guidelines 02229188 CRIXIVAN - 300MG/CAP indinavir sulfate J05AE capsule not sold No Current Sales 02229196 CRIXIVAN - 400MG/CAP indinavir sulfate J05AE capsule Within Guidelines 02298791 EMEND - 80MG/CAP aprepitant A04AD capsule introduced (nas) Within Guidelines 02298805 EMEND - 125MG/CAP aprepitant A04AD capsule introduced (nas) Within Guidelines www.pmprb-cepmb.gc.ca

22 Canadian Patentees and Patented Drug Products for Human Use DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status MERCK FROSST CANADA LTD. (continued) 02298813 EMEND 125MG/80MG TRIPAK aprepitant A04AD capsule introduced (nas) Within Guidelines 02247521 EZETROL - 10MG/TAB ezetimibe C10AX tablet Within Guidelines 02233055 FOSAMAX - 5MG/TAB alendronate sodium M05BA tablet Within Guidelines 02201011 FOSAMAX - 10MG/TAB alendronate sodium M05BA tablet Within Guidelines 02201038 FOSAMAX - 40MG/TAB alendronate sodium M05BA tablet Within Guidelines 02245329 FOSAMAX - 70MG/TAB alendronate sodium M05BA tablet Within Guidelines 02248625 FOSAMAX - 70MG/VIAL alendronate sodium M05BA oral solution Within Guidelines 02276429 FOSAVANCE - 70MG/TAB alendronate sodium/cholecalciferol M05BA tablet Within Guidelines 02283190 GARDASIL papillomavirus recombinant vaccine J07BM injectable suspension Within Guidelines 02297841 HYZAAR 100/12.5 losartan potassium/hydrochlorothiazide C09DA tablet introduced Within Guidelines 02230047 HYZAAR 50/12.5 losartan potassium/hydrochlorothiazide C09DA tablet Within Guidelines 02241007 HYZAAR DS 100/25 losartan potassium/hydrochlorothiazide C09DA tablet Within Guidelines 02247437 INVANZ - 1000MG/VIAL ertapenem sodium J01DH powder for injectable solution Within Guidelines 02301881 ISENTRESS - 400MG/TAB raltegravir potassium J05AX tablet introduced (nas) Under Review 02303922 JANUVIA - 100MG/TAB sitagliptin phosphate A10BH tablet not sold No Current Sales 02240520 MAXALT - 5MG/TAB rizatriptan benzoate N02CC tablet Within Guidelines 02240521 MAXALT - 10MG/TAB rizatriptan benzoate N02CC tablet Within Guidelines 02240518 MAXALT RPD - 5MG/WAFER rizatriptan benzoate N02CC wafer Within Guidelines 02240519 MAXALT RPD - 10MG/WAFER rizatriptan benzoate N02CC wafer Within Guidelines 00893668 MEFOXIN ADD-VANTAGE - 1000MG/VIAL cefoxitin sodium J01DA powder for injectable solution expired No Current Sales 00893676 MEFOXIN ADD-VANTAGE - 2000MG/VIAL cefoxitin sodium J01DA powder for injectable solution expired No Current Sales 00795844 MEVACOR - 10MG/TAB lovastatin C10AA tablet not sold No Current Sales 00795860 MEVACOR - 20MG/TAB lovastatin C10AA tablet Within Guidelines 00795852 MEVACOR - 40MG/TAB lovastatin C10AA tablet Within Guidelines 00643025 NOROXIN - 400MG/TAB norfloxacin J01MA tablet expired No Current Sales 00710121 PEPCID - 20MG/TAB famotidine A02BA tablet Within Guidelines 00710113 PEPCID - 40MG/TAB famotidine A02BA tablet Within Guidelines 02240934 PRINIVIL - 2.5MG/TAB lisinopril C09AA tablet not sold No Current Sales 00839388 PRINIVIL - 5MG/TAB lisinopril C09AA tablet Within Guidelines 00839396 PRINIVIL - 10MG/TAB lisinopril C09AA tablet Within Guidelines 00839418 PRINIVIL - 20MG/TAB lisinopril C09AA tablet Subj. Investigation 00839426 PRINIVIL - 40MG/TAB lisinopril C09AA tablet not sold No Current Sales 00839434 PRINIVIL - 80MG/TAB lisinopril C09AA tablet not sold No Current Sales 02108194 PRINZIDE 10/12.5 lisinopril/hydrochlorothiazide C09BA tablet expired Within Guidelines 00884413 PRINZIDE 20/12.5 lisinopril/hydrochlorothiazide C09BA tablet expired Within Guidelines 00884421 PRINZIDE 20/25 lisinopril/hydrochlorothiazide C09BA tablet expired Within Guidelines 02238213 PROPECIA - 1MG/TAB finasteride D11AX tablet Within Guidelines 02010909 PROSCAR - 5MG/TAB finasteride G04CB tablet Within Guidelines 00749486 RECOMBIVAX HB - 10MCG/ML vaccine - hepatitis B(rDNA) J07BC injectable suspension Within Guidelines 01934023 RECOMBIVAX HB - 40MCG/ML vaccine - hepatitis B(rDNA) J07BC injectable suspension not sold No Current Sales 02243676 RECOMBIVAX HB THIMEROSAL FREE - vaccine - hepatitis B(rDNA) J07BC injectable suspension Within Guidelines 10MCG/ML 02245977 RECOMBIVAX HB THIMEROSAL FREE - vaccine - hepatitis B(rDNA) J07BC injectable suspension Subj. Investigation 40MCG/ML 02284413 ROTATEQ oral live rotavirus vaccine, pentavalent J07BH oral suspension Within Guidelines 02247997 SINGULAIR - 4MG/POUCH montelukast sodium R03DC oral granules Within Guidelines 02243602 SINGULAIR - 4MG/TAB montelukast sodium R03DC chewable tablet Within Guidelines 02238216 SINGULAIR - 5MG/TAB montelukast sodium R03DC chewable tablet Within Guidelines 02238217 SINGULAIR - 10MG/TAB montelukast sodium R03DC tablet Within Guidelines 02171880 TIMOPTIC XE - 2.5MG/ML timolol maleate S01ED ophthalmic gel Within Guidelines 02171899 TIMOPTIC XE - 5MG/ML timolol maleate S01ED ophthalmic gel Within Guidelines

02216205 TRUSOPT - 20MG/ML dorzolamide hydrochloride S01EC ophthalmic solution Within Guidelines www.pmprb-cepmb.gc.ca

January 1 — December 31, 2007 Annual Report 2007 23 DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status MERCK FROSST CANADA LTD. (continued) 02269090 TRUSOPT PF - 20MG/ML dorzolamide hydrochloride S01EC ophthalmic solution Within Guidelines 02246081 VARIVAX III varicella virus vaccine,live,attenuated J07BK injectable suspension Within Guidelines 00657298 VASERETIC 10/25 enalapril maleate/hydrochlorothiazide C09BA tablet Within Guidelines 02242826 VASERETIC 5/12.5 enalapril maleate/hydrochlorothiazide C09BA tablet Within Guidelines 00851795 VASOTEC - 2.5MG/TAB enalapril maleate C09AA tablet expired Within Guidelines 00708879 VASOTEC - 5MG/TAB enalapril maleate C09AA tablet expired Within Guidelines 00670901 VASOTEC - 10MG/TAB enalapril maleate C09AA tablet expired Within Guidelines 00670928 VASOTEC - 20MG/TAB enalapril maleate C09AA tablet expired Within Guidelines 00708887 VASOTEC - 40MG/TAB enalapril maleate C09AA tablet expired No Current Sales 01923846 VASOTEC I.V. - 1.25MG/ML enalaprilat C09AA injectable solution Within Guidelines 00884324 ZOCOR - 5MG/TAB simvastatin C10AA tablet Within Guidelines 00884332 ZOCOR - 10MG/TAB simvastatin C10AA tablet Within Guidelines 00884340 ZOCOR - 20MG/TAB simvastatin C10AA tablet Within Guidelines 00884359 ZOCOR - 40MG/TAB simvastatin C10AA tablet Within Guidelines 02240332 ZOCOR - 80MG/TAB simvastatin C10AA tablet Within Guidelines

MERCK FROSST COMPANY 02241109 VIOXX - 2.5MG/ML rofecoxib M01AH oral suspension not sold No Current Sales 02241110 VIOXX - 5MG/ML rofecoxib M01AH oral suspension not sold No Current Sales 02241107 VIOXX - 12.5MG/TAB rofecoxib M01AH tablet not sold No Current Sales 02241108 VIOXX - 25MG/TAB rofecoxib M01AH tablet not sold No Current Sales 02243326 VIOXX - 50MG/TAB rofecoxib M01AH tablet not sold No Current Sales

MGI PHARMA CANADA CORP. 02238985 GLIADEL - 7.7MG/WAFER carmustine in polifeprosan 20 L01AD injectable implant expired Within Guidelines

NOVARTIS CONSUMER HEALTH CANADA INC. 01943065 HABITROL 14 - 35MG/PATCH nicotine N07BA transdermal patch Within Guidelines 01943073 HABITROL 21 - 52.5MG/PATCH nicotine N07BA transdermal patch Within Guidelines 01943057 HABITROL 7 - 17.5MG/PATCH nicotine N07BA transdermal patch Within Guidelines 02162318 MAALOX HRF antacid-alginate compound A02AA oral suspension not sold No Current Sales 02241226 TRANSDERMAL NICOTINE PATCH nicotine N07BA transdermal patch Within Guidelines 14 - 35MG/PATCH 02241228 TRANSDERMAL NICOTINE PATCH nicotine N07BA transdermal patch Within Guidelines 21 - 52.5MG/PATCH 02241227 TRANSDERMAL NICOTINE PATCH nicotine N07BA transdermal patch Within Guidelines 7 - 17.5MG/PATCH 02240450 TRIAMINIC SOFTCHEWS COLD & AL pseudoephed/cm R01BA chewable tablet Subj. Investigation 02240448 TRIAMINIC SOFTCHEWS COLD & CO pseudoephed/dm/cm R05DA chewable tablet Subj. Investigation 02243032 TRIAMINIC SOFTCHEWS COUGH - 7.5MG/TAB dextromethorphan hydrobromide R05DA chewable tablet not sold No Current Sales 02278731 TRIAMINIC SOFTCHEWS COUGH & S - dextromethorphan hydrobromide/acetaminophen N02BE chewable tablet Under Review 165MG/TAB 02240451 TRIAMINIC SOFTCHEWS THROAT PA pseudoephed/dm/apap N02BE chewable tablet not sold No Current Sales

NOVARTIS PHARMA CANADA INC. 02269198 ACLASTA - 5MG/VIAL zoledronic acid M05BA injectable solution Within Guidelines 02029901 AQUASITE 2/1 polyethylene glycol 400/dextran 70 S01XA ophthalmic drops not sold No Current Sales 02243763 COMTAN - 200MG/TAB entacapone N04BX tablet Within Guidelines 02236808 DIOVAN - 80MG/CAP valsartan C09CA capsule not sold No Current Sales 02236809 DIOVAN - 160MG/CAP valsartan C09CA capsule not sold No Current Sales 02270528 DIOVAN - 40MG/TAB valsartan C09CA tablet Within Guidelines www.pmprb-cepmb.gc.ca

24 Canadian Patentees and Patented Drug Products for Human Use DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status NOVARTIS PHARMA CANADA INC. (continued) 02244781 DIOVAN - 80MG/TAB valsartan C09CA tablet Within Guidelines 02244782 DIOVAN - 160MG/TAB valsartan C09CA tablet Within Guidelines 02289504 DIOVAN - 320MG/TAB valsartan C09CA tablet introduced Within Guidelines 02241901 DIOVAN-HCT 160/12.5 valsartan/hydrochlorothiazide C09DA tablet Within Guidelines 02246955 DIOVAN-HCT 160/25 valsartan/hydrochlorothiazide C09DA tablet Within Guidelines 02241900 DIOVAN-HCT 80/12.5 valsartan/hydrochlorothiazide C09DA tablet Within Guidelines 02247238 ELIDEL - 10MG/G pimecrolimus D11AX topical cream Within Guidelines 02273217 ENABLEX - 7.5MG/TAB darifenacin hydrobromide G04BD extended-release tablet Within Guidelines 02273225 ENABLEX - 15MG/TAB darifenacin hydrobromide G04BD extended-release tablet Within Guidelines 02241835 ESTALIS 140/50 norethindrone acetate/estradiol 17ß G03FA transdermal patch Within Guidelines 02241837 ESTALIS 250/50 norethindrone acetate/estradiol 17ß G03FA transdermal patch Within Guidelines 02243529 ESTALIS-SEQUI 140/50 norethindrone acetate/estradiol 17ß + G03FB transdermal patch Within Guidelines estradiol 17ß 02243530 ESTALIS-SEQUI 250/50 norethindrone acetate/estradiol 17ß + G03FB transdermal patch Within Guidelines estradiol 17ß 02108186 ESTRACOMB .05/.05-.25 estradiol 17ß/estradiol 17ß & norethindrone G03FA transdermal patch Within Guidelines acetate 02244002 ESTRADOT 100 - 1.56MG/PATCH estradiol 17ß G03CA transdermal patch Within Guidelines 02245676 ESTRADOT 25 - 0.39MG/PATCH estradiol 17ß G03CA transdermal patch Within Guidelines 02243999 ESTRADOT 37.5 - 0.585MG/PATCH estradiol 17ß G03CA transdermal patch Within Guidelines 02244000 ESTRADOT 50 - 0.78MG/PATCH estradiol 17ß G03CA transdermal patch Within Guidelines 02244001 ESTRADOT 75 - 1.17MG/PATCH estradiol 17ß G03CA transdermal patch Within Guidelines 02242115 EXELON - 1.5MG/CAP rivastigmine tartrate N06DA capsule Within Guidelines 02242116 EXELON - 3MG/CAP rivastigmine tartrate N06DA capsule Within Guidelines 02242117 EXELON - 4.5MG/CAP rivastigmine tartrate N06DA capsule Within Guidelines 02242118 EXELON - 6MG/CAP rivastigmine tartrate N06DA capsule Within Guidelines 02245240 EXELON - 2MG/ML rivastigmine tartrate N06DA oral solution Within Guidelines 02302853 EXELON 10 - 18MG/PATCH rivastigmine N06DA transdermal patch Under Review 02302845 EXELON 5 - 9MG/PATCH rivastigmine N06DA transdermal patch Under Review 02287420 EXJADE - 125MG/TAB deferasirox V03AC tablet for oral suspension Within Guidelines 02287439 EXJADE - 250MG/TAB deferasirox V03AC tablet for oral suspension Within Guidelines 02287447 EXJADE - 500MG/TAB deferasirox V03AC tablet for oral suspension Within Guidelines 02229110 FAMVIR - 125MG/TAB famciclovir J05AB tablet Within Guidelines 02229129 FAMVIR - 250MG/TAB famciclovir J05AB tablet Within Guidelines 02177102 FAMVIR - 500MG/TAB famciclovir J05AB tablet Within Guidelines 02231384 FEMARA - 2.5MG/TAB letrozole L02BG tablet Within Guidelines 02230898 FORADIL - 0.012MG/DOSE formoterol fumarate R03AC powder for inhalation expired No Current Sales 02244724 GLEEVEC - 50MG/CAP imatinib mesylate L01XX capsule not sold No Current Sales 02244725 GLEEVEC - 100MG/CAP imatinib mesylate L01XX capsule not sold No Current Sales 02253275 GLEEVEC - 100MG/TAB imatinib mesylate L01XX tablet Within Guidelines 02253283 GLEEVEC - 400MG/TAB imatinib mesylate L01XX tablet Within Guidelines 02239876 LAMISIL - 10MG/G terbinafine hydrochloride D01AE topical gel not sold No Current Sales 02238703 LAMISIL - 10MG/ML terbinafine hydrochloride D01AE topical spray Within Guidelines 02061562 LESCOL - 20MG/CAP fluvastatin sodium C10AA capsule Within Guidelines 02061570 LESCOL - 40MG/CAP fluvastatin sodium C10AA capsule Within Guidelines 02250527 LESCOL XL - 80MG/TAB fluvastatin sodium C10AA extended-release tablet Within Guidelines 02162873 LOTENSIN-HCT 10/12.5 benazepril hydrochloride/hydrochlorothiazide C09BA tablet not sold No Current Sales 02162881 LOTENSIN-HCT 20/25 benazepril hydrochloride/hydrochlorothiazide C09BA tablet not sold No Current Sales 02162865 LOTENSIN-HCT 5/6.25 benazepril hydrochloride/hydrochlorothiazide C09BA tablet not sold No Current Sales 01990926 MIACALCIN - 50UNIT/ML calcitonin salmon H05BA injectable solution not sold No Current Sales 01992880 MIACALCIN - 100UNIT/ML calcitonin salmon H05BA injectable solution not sold No Current Sales 02264560 MYFORTIC - 180MG/TAB mycophenolate sodium L04AA tablet Within Guidelines www.pmprb-cepmb.gc.ca

January 1 — December 31, 2007 Annual Report 2007 25 DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status NOVARTIS PHARMA CANADA INC. (continued) 02264579 MYFORTIC - 360MG/TAB mycophenolate sodium L04AA tablet Within Guidelines 02237671 NEORAL - 10MG/CAP cyclosporine L04AA capsule Within Guidelines 02150689 NEORAL - 25MG/CAP cyclosporine L04AA capsule Within Guidelines 02150662 NEORAL - 50MG/CAP cyclosporine L04AA capsule Within Guidelines 02150670 NEORAL - 100MG/CAP cyclosporine L04AA capsule Within Guidelines 02150697 NEORAL - 100MG/ML cyclosporine L04AA oral solution Within Guidelines 02130181 PROLEUKIN - 22000000UNIT/VIAL aldesleukin L03AC powder for injectable solution Within Guidelines 02302063 RASILEZ - 150MG/TAB aliskiren C09XA tablet introduced (nas) Under Review 02302071 RASILEZ - 300MG/TAB aliskiren C09XA tablet introduced (nas) Under Review 02245525 RESCULA - 1.5MG/ML unoprostone isopropyl S01EX ophthalmic solution not sold No Current Sales 02229854 RESTORIL - 7.5MG/CAP temazepam N05CD capsule not sold No Current Sales 00755591 SANDIMMUNE - 25MG/CAP cyclosporine L04AA capsule not sold No Current Sales 01907182 SANDIMMUNE - 50MG/CAP cyclosporine L04AA capsule not sold No Current Sales 00755605 SANDIMMUNE - 100MG/CAP cyclosporine L04AA capsule not sold No Current Sales 00593257 SANDIMMUNE - 50MG/ML cyclosporine L04AA injectable solution Within Guidelines 00593249 SANDIMMUNE - 100MG/ML cyclosporine L04AA oral solution not sold No Current Sales 00839191 SANDOSTATIN - 0.05MG/ML octreotide H01CB injectable solution Within Guidelines 00839205 SANDOSTATIN - 0.1MG/ML octreotide H01CB injectable solution Within Guidelines 02049392 SANDOSTATIN - 0.2MG/ML octreotide H01CB injectable solution Within Guidelines 00839213 SANDOSTATIN - 0.5MG/ML octreotide H01CB injectable solution Within Guidelines 02239323 SANDOSTATIN LAR - 10MG/VIAL octreotide H01CB powder for injectable solution Within Guidelines 02239324 SANDOSTATIN LAR - 20MG/VIAL octreotide H01CB powder for injectable solution Within Guidelines 02239325 SANDOSTATIN LAR - 30MG/VIAL octreotide H01CB powder for injectable solution Within Guidelines 02288389 SEBIVO - 600MG/TAB telbivudine J05AF tablet introduced (nas) Within Guidelines 02242815 SIMULECT - 20MG/VIAL basiliximab L04AA powder for injectable solution Within Guidelines 02245438 STARLIX - 60MG/TAB nateglinide A10BX tablet Within Guidelines 02245439 STARLIX - 120MG/TAB nateglinide A10BX tablet Within Guidelines 02245440 STARLIX - 180MG/TAB nateglinide A10BX tablet Within Guidelines 02239630 TOBI - 300MG/AMPOULE tobramycin sulfate J01GB solution for inhalation Within Guidelines 02242067 TRILEPTAL - 150MG/TAB oxcarbazepine N03AF tablet Subj. Investigation 02242068 TRILEPTAL - 300MG/TAB oxcarbazepine N03AF tablet Subj. Investigation 02242069 TRILEPTAL - 600MG/TAB oxcarbazepine N03AF tablet Subj. Investigation 02230732 TRINIPATCH 0.2 - 22.4MG/PATCH nitroglycerin C01DA transdermal patch Under Review 02230733 TRINIPATCH 0.4 - 44.8MG/PATCH nitroglycerin C01DA transdermal patch Under Review 02230734 TRINIPATCH 0.6 - 67.2MG/PATCH nitroglycerin C01DA transdermal patch Under Review 02242367 VISUDYNE - 15MG/VIAL verteporfin L01XX powder for injectable solution Within Guidelines 02204444 VIVELLE 100 - 8.66MG/PATCH estradiol 17ß G03CA transdermal patch not sold No Current Sales 02243488 VIVELLE 25 - 2.16MG/PATCH estradiol 17ß G03CA transdermal patch not sold No Current Sales 02204401 VIVELLE 37.5 - 3.28MG/PATCH estradiol 17ß G03CA transdermal patch not sold No Current Sales 02204428 VIVELLE 50 - 4.33MG/PATCH estradiol 17ß G03CA transdermal patch not sold No Current Sales 02204436 VIVELLE 75 - 6.56MG/PATCH estradiol 17ß G03CA transdermal patch not sold No Current Sales 01940414 VOLTAREN OPHTHA - 1MG/ML diclofenac sodium S01BC ophthalmic drops Within Guidelines 02260565 XOLAIR - 150MG/VIAL omalizumab R03DX powder for injectable solution Within Guidelines 02245566 ZELNORM - 6MG/TAB tegaserod maleate A03AE powder for injectable solution Within Guidelines 02242725 ZOMETA - 4MG/VIAL zoledronic acid M05BA powder for injectable solution not sold No Curent Sales 02248296 ZOMETA - 4MG/VIAL zoledronic acid M05BA injectable solution Within Guidelines

NOVO NORDISK CANADA INC. 02239924 GLUCONORM - 0.5MG/TAB repaglinide A10BX tablet Within Guidelines 02239925 GLUCONORM - 1MG/TAB repaglinide A10BX tablet Within Guidelines 02239926 GLUCONORM - 2MG/TAB repaglinide A10BX tablet Within Guidelines www.pmprb-cepmb.gc.ca

26 Canadian Patentees and Patented Drug Products for Human Use DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status NOVO NORDISK CANADA INC. (continued) 02271850 LEVEMIR FLEXPEN - 100UNIT/ML insulin detemir A10AE injectable solution not sold No Current Sales 02271869 LEVEMIR INNOLET - 100UNIT/ML insulin detemir A10AE injectable solution not sold No Current Sales 02271842 LEVEMIR PENFILL - 100UNIT/ML insulin detemir A10AE injectable solution Subj. Investigation 02056682 LOGIPARIN - 10000UNIT/ML tinzaparin sodium B01AB injectable suspension not sold No Current Sales 02056690 LOGIPARIN - 11700UNIT/ML tinzaparin sodium B01AB injectable suspension not sold No Current Sales 02239659 NIASTASE - 1.2MG/VIAL eptacog alfa (activated) B02BD powder for injectable solution Within Guidelines 02239660 NIASTASE - 2.4MG/VIAL eptacog alfa (activated) B02BD powder for injectable solution Within Guidelines 02239661 NIASTASE - 4.8MG/VIAL eptacog alfa (activated) B02BD powder for injectable solution Within Guidelines 02024292 NOVOLIN GE 10/90 - 100UNIT/ML insulin (regular/isophane) human biosynthetic A10AD injectable suspension Within Guidelines 02245179 NOVOLIN GE 10/90 INNOLET - 100UNIT/ML insulin (isophane) human biosynthetic A10AC injectable suspension not sold No Current Sales 02024306 NOVOLIN GE 20/80 - 100UNIT/ML insulin (regular/isophane) human biosynthetic A10AD injectable suspension Within Guidelines 02245180 NOVOLIN GE 20/80 INNOLET - 100UNIT/ML insulin (isophane) human biosynthetic A10AC injectable suspension not sold No Current Sales 02024217 NOVOLIN GE 30/70 - 100UNIT/ML insulin (regular/isophane) human biosynthetic A10AD injectable suspension Within Guidelines 02025248 NOVOLIN GE 30/70 - 100UNIT/ML insulin (regular/isophane) human biosynthetic A10AD injectable suspension Within Guidelines 02245181 NOVOLIN GE 30/70 INNOLET - 100UNIT/ML insulin (isophane) human biosynthetic A10AC injectable suspension not sold No Current Sales 02024314 NOVOLIN GE 40/60 - 100UNIT/ML insulin (regular/isophane) human biosynthetic A10AD injectable suspension Within Guidelines 02245182 NOVOLIN GE 40/60 INNOLET - 100UNIT/ML insulin (isophane) human biosynthetic A10AC injectable suspension not sold No Current Sales 02024322 NOVOLIN GE 50/50 - 100UNIT/ML insulin (regular/isophane) human biosynthetic A10AD injectable suspension Within Guidelines 02245183 NOVOLIN GE 50/50 INNOLET - 100UNIT/ML insulin (isophane) human biosynthetic A10AC injectable suspension not sold No Current Sales 02024241 NOVOLIN GE LENTE - 100UNIT/ML insulin (lente) human biosynthetic A10AC injectable suspension not sold No Current Sales 02024225 NOVOLIN GE NPH - 100UNIT/ML insulin (isophane) human biosynthetic A10AC injectable suspension Within Guidelines 02024268 NOVOLIN GE NPH - 100UNIT/ML insulin (isophane) human biosynthetic A10AC injectable suspension Within Guidelines 02245177 NOVOLIN GE NPH INNOLET - 100UNIT/ML insulin (isophane) human biosynthetic A10AC injectable suspension not sold No Current Sales 02024233 NOVOLIN GE TORONTO - 100UNIT/ML insulin (regular) human biosynthetic A10AB injectable suspension Within Guidelines 02024284 NOVOLIN GE TORONTO - 100UNIT/ML insulin (regular) human biosynthetic A10AB injectable suspension Within Guidelines 02245178 NOVOLIN GE TORONTO INNOLET - 100UNIT/ML insulin (isophane) human biosynthetic A10AB injectable suspension not sold No Current Sales 02024276 NOVOLIN GE ULTRALENTE - 100UNIT/ML insulin (ultralente) human biosynthetic A10AE injectable suspension not sold No Current Sales 01988700 NOVOLINSET 30/70 - 100UNIT/ML insulin (regular/isophane) human semi-synthetic A10AD injectable suspension not sold No Current Sales 02024411 NOVOLINSET GE 10/90 - 100UNIT/ML insulin (regular/isophane) human biosynthetic A10AD injectable suspension not sold No Current Sales 02024438 NOVOLINSET GE 20/80 - 100UNIT/ML insulin (regular/isophane) human biosynthetic A10AD injectable suspension not sold No Current Sales 02024446 NOVOLINSET GE 30/70 - 100UNIT/ML insulin (regular/isophane) human biosynthetic A10AD injectable suspension not sold No Current Sales 02024454 NOVOLINSET GE 40/60 - 100UNIT/ML insulin (regular/isophane) human biosynthetic A10AD injectable suspension not sold No Current Sales 02025264 NOVOLINSET GE 50/50 - 100UNIT/ML insulin (regular/isophane) human biosynthetic A10AD injectable suspension not sold No Current Sales 02024403 NOVOLINSET GE NPH - 100UNIT/ML insulin (isophane) human biosynthetic A10AC injectable suspension not sold No Current Sales 02025256 NOVOLINSET GE TORONTO - 100UNIT/ML insulin (regular) human biosynthetic A10AB injectable suspension not sold No Current Sales 01986090 NOVOLINSET NPH - 100UNIT/ML insulin (isophane) human semi-synthetic A10AC injectable suspension not sold No Current Sales 01927477 NOVOLINSET TORONTO - 100UNIT/ML insulin (regular) human semi-synthetic A10AB injectable suspension not sold No Current Sales 02265443 NOVOMIX 30 FLEXPEN - 100UNIT/ML insulin aspart/insulin aspart protamine A10AD injectable suspension not sold No Current Sales 02265435 NOVOMIX 30 PENFILL - 100UNIT/ML insulin aspart/insulin aspart protamine A10AD injectable suspension introduced Within Guidelines 02292459 NOVOMIX 50 FLEXPEN - 100UNIT/ML insulin aspart/insulin aspart protamine A10AD injectable suspension not sold No Current Sales 02292440 NOVOMIX 50 PENFILL - 100UNIT/ML insulin aspart/insulin aspart protamine A10AD injectable suspension not sold No Current Sales 02292475 NOVOMIX 70 FLEXPEN - 100UNIT/ML insulin aspart/insulin aspart protamine A10AD injectable suspension not sold No Current Sales 02292467 NOVOMIX 70 PENFILL - 100UNIT/ML insulin aspart/insulin aspart protamine A10AD injectable suspension not sold No Current Sales 02244353 NOVORAPID - 100UNIT/ML insulin aspart A10AB injectable solution Within Guidelines 02245397 NOVORAPID - 100UNIT/ML insulin aspart A10AB injectable solution Within Guidelines

NYCOMED CANADA INC. 02285592 ALVESCO - 50MCG/DOSE ciclesonide R03BA aerosol for inhalation not sold No Current Sales 02285606 ALVESCO - 100MCG/DOSE ciclesonide R03BA aerosol for inhalation Within Guidelines 02285614 ALVESCO - 200MCG/DOSE ciclesonide R03BA aerosol for inhalation Within Guidelines 02303671 OMNARIS - 50MCG/DOSE ciclesonide R03BA nasal spray not sold No Current Sales www.pmprb-cepmb.gc.ca

January 1 — December 31, 2007 Annual Report 2007 27 DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status NYCOMED CANADA INC. (continued) 02239616 PANTO IV - 40MG/VIAL pantoprazole sodium A02BC powder for injectable solution Within Guidelines 02224151 PANTO-BYK - 40MG/TAB pantoprazole sodium A02BC tablet not sold No Current Sales 02241804 PANTOLOC - 20MG/TAB pantoprazole sodium A02BC tablet Within Guidelines 02229453 PANTOLOC - 40MG/TAB pantoprazole sodium A02BC tablet Within Guidelines 02267233 PANTOLOC M - 40MG/TAB pantoprazole magnesium A02BC tablet Within Guidelines

ORGANON CANADA LTD. (AKZO) 00782327 ANDRIOL - 40MG/CAP testosterone undecanoate G03BA capsule Subj. Investigation 02253186 NUVARING etonogestrel/ethinyl estradiol G03F vaginal ring Within Guidelines 02245641 ORGALUTRAN - 250MCG/SYRINGE ganirelix acetate H01CC injectable solution Subj. Investigation 02231655 PUREGON - 50UNIT/AMPOULE follitropin beta G03GA powder for injectable solution not sold No Current Sales 02231654 PUREGON - 75UNIT/AMPOULE follitropin beta G03GA powder for injectable solution not sold No Current Sales 02231656 PUREGON - 100UNIT/AMPOULE follitropin beta G03GA powder for injectable solution not sold No Current Sales 02231657 PUREGON - 150UNIT/AMPOULE follitropin beta G03GA powder for injectable solution not sold No Current Sales 02248542 REMERON RD - 15MG/TAB mirtazapine N06AX orally disintegrating tablet Within Guidelines 02248543 REMERON RD - 30MG/TAB mirtazapine N06AX orally disintegrating tablet Within Guidelines 02248544 REMERON RD - 45MG/TAB mirtazapine N06AX orally disintegrating tablet Within Guidelines 02108208 ZEMURON - 10MG/ML rocuronium bromide M03AC injectable solution Within Guidelines

ORYX PHARMACEUTICALS INC. 02270447 ADVICOR 1000/20 niacin/lovastatin C10BA tablet Within Guidelines 02293501 ADVICOR 1000/40 niacin/lovastatin C10BA tablet No Current Sales 02270439 ADVICOR 500/20 niacin/lovastatin C10BA tablet Within Guidelines 02293498 ADVICOR 750/20 niacin/lovastatin C10BA tablet not sold No Current Sales 02246533 ANGIOMAX - 250MG/VIAL bivalirudin B01AE powder for injectable solution Within Guidelines 02299909 CUBICIN - 500MG/VIAL daptomycin J01XX powder for injectable solution Under Review 02242505 NAPRELAN 375 - 412.5MG/TAB naproxen sodium M01AE controlled-release tablet introduced Within Guidelines 02242506 NAPRELAN 500 - 550MG/TAB naproxen sodium M01AE controlled-release tablet introduced Within Guidelines 02262347 NIASPAN - 500MG/TAB niacin C10AD tablet Within Guidelines 02262355 NIASPAN - 750MG/TAB niacin C10AD tablet Within Guidelines 02262339 NIASPAN - 1000MG/TAB niacin C10AD tablet Within Guidelines 02162687 RHINALAR - 0.25MG/ML flunisolide R01AD nasal aerosol Within Guidelines

OVATION PHARMACEUTICALS INC. 02068036 SABRIL - 500MG/POUCH vigabatrin N03AG powder for oral solution Within Guidelines 02065819 SABRIL - 500MG/TAB vigabatrin N03AG tablet Within Guidelines

PALADIN LABS INC. 02239653 ANDRODERM - 12.2MG/PATCH testosterone G03BA transdermal patch Within Guidelines 02245972 ANDRODERM - 24.3MG/PATCH testosterone G03BA transdermal patch Within Guidelines 02241150 DEPOCYT - 10MG/ML cytarabine, liposomal L01BC injectable suspension not sold No Current Sales 02238592 MUSE - 0.125MG/SUP alprostadil G04BE intraurethral micro-suppository not sold No Current Sales 02238593 MUSE - 0.25MG/SUP alprostadil G04BE intraurethral micro-suppository Within Guidelines 02238594 MUSE - 0.5MG/SUP alprostadil G04BE intraurethral micro-suppository Within Guidelines 02238595 MUSE - 1MG/SUP alprostadil G04BE intraurethral micro-suppository Within Guidelines 02254735 OXYTROL - 36MG/PATCH oxybutynin G04BD transdermal patch Within Guidelines 02280248 TESTIM 1% - 5GM/TUBE testosterone G03BA topical gel introduced Within Guidelines 02240000 TRELSTAR - 3.75MG/VIAL triptorelin pamoate L02AE microgranules for injectable Within Guidelines suspension 02243856 TRELSTAR LA - 11.25MG/VIAL triptorelin pamoate L02AE microgranules for injectable Within Guidelines suspension www.pmprb-cepmb.gc.ca

28 Canadian Patentees and Patented Drug Products for Human Use DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status PALADIN LABS INC. (continued) 02268205 TWINJECT - 0.15MG/DOSE epinephrine C01CA injectable solution Within Guidelines 02247310 TWINJECT - 0.3MG/DOSE epinephrine C01CA injectable solution Within Guidelines 02278383 VANTAS - 50MG/IMP histrelin acetate H01CA injectable implant not sold No Current Sales

PDL BIOPHARMA INC. 02240602 BUSULFEX - 60MG/AMPOULE busulfan L01AB injectable solution Within Guidelines

PFIZER CANADA INC. 01947664 ACCUPRIL - 5MG/TAB quinapril hydrochloride C09AA tablet Within Guidelines 01947672 ACCUPRIL - 10MG/TAB quinapril hydrochloride C09AA tablet Within Guidelines 01947680 ACCUPRIL - 20MG/TAB quinapril hydrochloride C09AA tablet Within Guidelines 01947699 ACCUPRIL - 40MG/TAB quinapril hydrochloride C09AA tablet Within Guidelines 02237367 ACCURETIC 10/12.5 quinapril hydrochloride/hydrochlorothiazide C09BA tablet Within Guidelines 02237368 ACCURETIC 20/12.5 quinapril hydrochloride/hydrochlorothiazide C09BA tablet Within Guidelines 02237369 ACCURETIC 20/25 quinapril hydrochloride/hydrochlorothiazide C09BA tablet Within Guidelines 02071002 ADRIAMYCIN PFS - 2MG/ML doxorubicin hydrochloride L01DB injectable solution Subj. Investigation 02205971 AMBIEN - 5MG/TAB zolpidem tartrate N05CF tablet not sold No Current Sales 02205998 AMBIEN - 10MG/TAB zolpidem tartrate N05CF tablet not sold No Current Sales 02232043 ARICEPT - 5MG/TAB donepezil hydrochloride N06DA tablet Within Guidelines 02232044 ARICEPT - 10MG/TAB donepezil hydrochloride N06DA tablet Within Guidelines 02269457 ARICEPT RDT - 5MG/TAB donepezil hydrochloride N06DA rapidly disintegrating tablet Within Guidelines 02269465 ARICEPT RDT - 10MG/TAB donepezil hydrochloride N06DA rapidly disintegrating tablet Within Guidelines 02242705 AROMASIN - 25MG/TAB exemestane L02BG tablet Within Guidelines 01917056 ARTHROTEC 0.2/50 misoprostol/diclofenac sodium M01AB tablet Within Guidelines 02229837 ARTHROTEC 0.2/75 misoprostol/diclofenac sodium M01AB tablet Within Guidelines 02246621 BEXTRA - 10MG/TAB valdecoxib M01AH tablet not sold No Current Sales 02246622 BEXTRA - 20MG/TAB valdecoxib M01AH tablet not sold No Current Sales 02246623 BEXTRA - 40MG/TAB valdecoxib M01AH tablet not sold No Current Sales 02273284 CADUET 10/10 amlodipine besylate/atorvastatin calcium C10AA tablet Within Guidelines 02273292 CADUET 10/20 amlodipine besylate/atorvastatin calcium C10AA tablet Within Guidelines 02273306 CADUET 10/40 amlodipine besylate/atorvastatin calcium C10AA tablet Within Guidelines 02273314 CADUET 10/80 amlodipine besylate/atorvastatin calcium C10AA tablet Within Guidelines 02273233 CADUET 5/10 amlodipine besylate/atorvastatin calcium C10AA tablet Within Guidelines 02273241 CADUET 5/20 amlodipine besylate/atorvastatin calcium C10AA tablet Within Guidelines 02273268 CADUET 5/40 amlodipine besylate/atorvastatin calcium C10AA tablet Within Guidelines 02273276 CADUET 5/80 amlodipine besylate/atorvastatin calcium C10AA tablet Within Guidelines 02231622 CAMPTOSAR - 20MG/ML irinotecan hydrochloride L01XX injectable solution Within Guidelines 02239941 CELEBREX - 100MG/CAP celecoxib M01AH capsule Within Guidelines 02239942 CELEBREX - 200MG/CAP celecoxib M01AH capsule Within Guidelines 02247690 CELEBREX - 400MG/CAP celecoxib M01AH capsule not sold No Current Sales 02299844 CELSENTRI - 150MG/TAB maraviroc J05AX tablet introduced (nas) Within Guidelines 02299852 CELSENTRI - 300MG/TAB maraviroc J05AX tablet introduced (nas) Within Guidelines CERICLAMINE - 100MG/CAP cericlamine N06AB capsule not sold No Current Sales CERICLAMINE - 150MG/CAP cericlamine N06AB capsule not sold No Current Sales 02291177 CHAMPIX - 0.5MG/TAB varenicline tartrate N07BA tablet introduced (nas) Within Guidelines 02291185 CHAMPIX - 1MG/TAB varenicline tartrate N07BA tablet introduced (nas) Within Guidelines 02298309 CHAMPIX 0.5/1.0 varenicline tartrate N07BA tablet introduced (nas) Within Guidelines 02231676 CHRONOVERA - 180MG/TAB verapamil hydrochloride C08DA extended-release tablet not sold No Current Sales 02231677 CHRONOVERA - 240MG/TAB verapamil hydrochloride C08DA extended-release tablet not sold No Current Sales COGNEX - 10MG/CAP tacrine hydrochloride N06DA capsule not sold No Current Sales COGNEX - 20MG/CAP tacrine hydrochloride N06DA capsule not sold No Current Sales www.pmprb-cepmb.gc.ca

January 1 — December 31, 2007 Annual Report 2007 29 DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status PFIZER CANADA INC. (continued) COGNEX - 30MG/CAP tacrine hydrochloride N06DA capsule not sold No Current Sales COGNEX - 40MG/CAP tacrine hydrochloride N06DA capsule not sold No Current Sales 02132680 COLESTID - 1000MG/TAB colestipol hydrochloride C10AC tablet Within Guidelines 02132699 COLESTID ORANGE - 7500MG/DOSE colestipol hydrochloride C10AC oral granules Within Guidelines 00030910 CORTEF - 10MG/TAB hydrocortisone H02AB tablet Within Guidelines 00030929 CORTEF - 20MG/TAB hydrocortisone H02AB tablet Within Guidelines 01934325 DEPO-MEDROL - 20MG/ML methylprednisolone acetate H02AB injectable suspension Within Guidelines 00030759 DEPO-MEDROL - 40MG/ML methylprednisolone acetate H02AB injectable suspension Within Guidelines 01934333 DEPO-MEDROL - 40MG/ML methylprednisolone acetate H02AB injectable suspension Within Guidelines 00030767 DEPO-MEDROL - 80MG/ML methylprednisolone acetate H02AB injectable suspension Within Guidelines 01934341 DEPO-MEDROL - 80MG/ML methylprednisolone acetate H02AB injectable suspension Within Guidelines 00260428 DEPO-MEDROL 40/10 methylprednisolone acetate/lidocaine H02BX injectable suspension Within Guidelines hydrochloride 02239064 DETROL - 1MG/TAB tolterodine tartrate G04BD tablet Within Guidelines 02239065 DETROL - 2MG/TAB tolterodine tartrate G04BD tablet Within Guidelines 02244612 DETROL LA - 2MG/CAP tolterodine tartrate G04BD extended-release capsule Within Guidelines 02244613 DETROL LA - 4MG/CAP tolterodine tartrate G04BD extended-release capsule Within Guidelines 00891835 DIFLUCAN - 2MG/ML fluconazole J02AC injectable solution Within Guidelines 02302160 ERAXIS - 100MG/VIAL anidulafungin J02AX powder for injectable solution not sold No Current Sales 02168898 ESTRING - 2MG/RING estradiol G03CA vaginal ring Within Guidelines 02293277 EXUBERA - 1MG/DOSE insulin human, rdna A10AF powder for inhalation not sold No Current Sales 02293285 EXUBERA - 3MG/DOSE insulin human, rdna A10AF powder for inhalation not sold No Current Sales 02230443 GLUCOTROL XL - 5MG/TAB glipizide A10BB extended-release tablet not sold No Current Sales 02230444 GLUCOTROL XL - 10MG/TAB glipizide A10BB extended-release tablet not sold No Current Sales 02239474 GLYSET - 25MG/TAB miglitol A10BF tablet expired No Current Sales 02239475 GLYSET - 50MG/TAB miglitol A10BF tablet expired No Current Sales 02239476 GLYSET - 100MG/TAB miglitol A10BF tablet expired No Current Sales 02166100 IDAMYCIN - 5MG/CAP idarubicin hydrochloride L01DB capsule not sold No Current Sales 02166119 IDAMYCIN - 10MG/CAP idarubicin hydrochloride L01DB capsule not sold No Current Sales 02166127 IDAMYCIN - 25MG/CAP idarubicin hydrochloride L01DB capsule not sold No Current Sales 02065630 IDAMYCIN - 5MG/VIAL idarubicin hydrochloride L01DB powder for injectable solution Within Guidelines 02068095 IDAMYCIN - 10MG/VIAL idarubicin hydrochloride L01DB powder for injectable solution not sold No Current Sales 02282496 IDAMYCIN PFS - 1MG/ML idarubicin hydrochloride L01DB injectable solution Within Guidelines 02230711 LIPITOR - 10MG/TAB atorvastatin calcium C10AA tablet Within Guidelines 02230713 LIPITOR - 20MG/TAB atorvastatin calcium C10AA tablet Within Guidelines 02230714 LIPITOR - 40MG/TAB atorvastatin calcium C10AA tablet Within Guidelines 02243097 LIPITOR - 80MG/TAB atorvastatin calcium C10AA tablet Within Guidelines 02268418 LYRICA - 25MG/CAP pregabalin N03AX capsule Within Guidelines 02268426 LYRICA - 50MG/CAP pregabalin N03AX capsule Within Guidelines 02268434 LYRICA - 75MG/CAP pregabalin N03AX capsule Within Guidelines 02268442 LYRICA - 100MG/CAP pregabalin N03AX capsule not sold No Current Sales 02268450 LYRICA - 150MG/CAP pregabalin N03AX capsule Subj. Investigation 02268469 LYRICA - 200MG/CAP pregabalin N03AX capsule not sold No Current Sales 02268477 LYRICA - 225MG/CAP pregabalin N03AX capsule not sold No Current Sales 02268485 LYRICA - 300MG/CAP pregabalin N03AX capsule Within Guidelines 02267225 MACUGEN - 0.3MG/SYRINGE pegaptanib sodium S01XA injectable solution Within Guidelines 00031062 MEDROL - 2.5MG/G methylprednisolone acetate D07AA topical cream not sold No Current Sales 00030988 MEDROL - 4MG/TAB methylprednisolone H02AB tablet Within Guidelines 00036129 MEDROL - 16MG/TAB methylprednisolone H02AB tablet Within Guidelines 00252395 MEDROL 2.5/50/100 methylprednisolone acetate/colloidal sulfur/al. D10AA topical solution Within Guidelines chlorhyd

www.pmprb-cepmb.gc.ca 00194913 NEO-CORTEF 10/5 hydrocortisone acetate/neomycin sulfate D07CA ointment not sold No Current Sales

30 Canadian Patentees and Patented Drug Products for Human Use DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status PFIZER CANADA INC. (continued) 00194921 NEO-CORTEF 15/5 hydrocortisone acetate/neomycin sulfate S01CA ophthalmic ointment not sold No Current Sales 00194948 NEO-CORTEF 15/5 hydrocortisone acetate/neomycin sulfate S01CA ophthalmic suspension not sold No Current Sales 00194883 NEO-CORTEF 5/5 hydrocortisone acetate/neomycin sulfate S01CA ophthalmic ointment not sold No Current Sales 00194891 NEO-CORTEF 5/5 hydrocortisone acetate/neomycin sulfate D07CA ointment not sold No Current Sales 00195057 NEO-MEDROL 2.5/2.5/50/100 methylprednisolone/neomycin/colloidal D10AA topical solution Within Guidelines sulfur/al. chlorhy 00194867 NEO-MEDROL 2.5/5 - 7.5MG/G methylprednisolone acetate/neomycin sulfate D07CA topical cream not sold No Current Sales 02084260 NEURONTIN - 100MG/CAP gabapentin N03AX capsule Within Guidelines 02084279 NEURONTIN - 300MG/CAP gabapentin N03AX capsule Subj. Investigation 02084287 NEURONTIN - 400MG/CAP gabapentin N03AX capsule Within Guidelines 02239717 NEURONTIN - 600MG/TAB gabapentin N03AX tablet Within Guidelines 02239718 NEURONTIN - 800MG/TAB gabapentin N03AX tablet Within Guidelines 00878901 NORVASC - 2.5MG/TAB amlodipine besylate C08CA tablet not sold No Current Sales 00878928 NORVASC - 5MG/TAB amlodipine besylate C08CA tablet Within Guidelines 00878936 NORVASC - 10MG/TAB amlodipine besylate C08CA tablet Within Guidelines 02089793 OGEN - 0.625MG/TAB estropipate G03CA tablet Within Guidelines 02089769 OGEN - 1.25MG/TAB estropipate G03CA tablet Within Guidelines 02089777 OGEN - 2.5MG/TAB estropipate G03CA tablet Within Guidelines 02065703 PHARMORUBICIN PFS - 2MG/ML epirubicin hydrochloride L01DB injectable solution Within Guidelines 02256290 RELPAX - 20MG/TAB eletriptan hydrobromide N02CC tablet Within Guidelines 02256304 RELPAX - 40MG/TAB eletriptan hydrobromide N02CC tablet Within Guidelines 02238348 RESCRIPTOR - 100MG/TAB delavirdine mesylate J05AG tablet Within Guidelines 02279401 REVATIO - 20MG/TAB sildenafil citrate G04BE tablet Within Guidelines 00030600 SOLU-CORTEF - 100MG/VIAL hydrocortisone sodium succinate H02AB powder for injectable solution Within Guidelines 00030619 SOLU-CORTEF - 250MG/VIAL hydrocortisone sodium succinate H02AB powder for injectable solution Within Guidelines 00030627 SOLU-CORTEF - 500MG/VIAL hydrocortisone sodium succinate H02AB powder for injectable solution Within Guidelines 00030635 SOLU-CORTEF - 1000MG/VIAL hydrocortisone sodium succinate H02AB powder for injectable solution Subj. Investigation 02063719 SOLU-MEDROL - 40MG/VIAL methylprednisolone sodium succinate H02AB powder for injectable solution Within Guidelines 02230211 SOLU-MEDROL - 40MG/VIAL methylprednisolone sodium succinate H02AB powder for injectable solution not sold No Current Sales 00030651 SOLU-MEDROL - 125MG/VIAL methylprednisolone sodium succinate H02AB powder for injectable solution not sold No Current Sales 02063727 SOLU-MEDROL - 125MG/VIAL methylprednisolone sodium succinate H02AB powder for injectable solution Within Guidelines 02230210 SOLU-MEDROL - 125MG/VIAL methylprednisolone sodium succinate H02AB powder for injectable solution not sold No Current Sales 00030678 SOLU-MEDROL - 500MG/VIAL methylprednisolone sodium succinate H02AB powder for injectable solution Subj. Investigation 02063700 SOLU-MEDROL - 500MG/VIAL methylprednisolone sodium succinate H02AB powder for injectable solution Within Guidelines 00036137 SOLU-MEDROL - 1000MG/VIAL methylprednisolone sodium succinate H02AB powder for injectable solution Within Guidelines 02063697 SOLU-MEDROL - 1000MG/VIAL methylprednisolone sodium succinate H02AB powder for injectable solution Subj. Investigation 02272199 SOMAVERT - 10MG/VIAL pegvisomant H01AX powder for injectable solution Within Guidelines 02272202 SOMAVERT - 15MG/VIAL pegvisomant H01AX powder for injectable solution Within Guidelines 02272210 SOMAVERT - 20MG/VIAL pegvisomant H01AX powder for injectable solution Within Guidelines 02280795 SUTENT - 12.5MG/CAP sunitinib malate L01XE capsule Within Guidelines 02280809 SUTENT - 25MG/CAP sunitinib malate L01XE capsule Within Guidelines 02280817 SUTENT - 50MG/CAP sunitinib malate L01XE capsule Within Guidelines 02188783 SYNAREL nafarelin acetate H01CA nasal solution Within Guidelines 02239191 TROVAN - 100MG/TAB trovafloxacin mesylate J01MA tablet not sold No Current Sales 02239192 TROVAN - 200MG/TAB trovafloxacin mesylate J01MA tablet not sold No Current Sales 02239145 TROVAN IV - 5MG/ML alatrofloxacin mesylate J01MA injectable solution not sold No Current Sales 02279991 VFEND - 40MG/ML voriconazole J02AC powder for oral suspension not sold No Current Sales 02256460 VFEND - 50MG/TAB voriconazole J02AC tablet Within Guidelines 02256479 VFEND - 200MG/TAB voriconazole J02AC tablet Within Guidelines 02256487 VFEND - 200MG/VIAL voriconazole J02AC powder for injectable solution Within Guidelines 02239766 VIAGRA - 25MG/TAB sildenafil citrate G04BE tablet Within Guidelines www.pmprb-cepmb.gc.ca

January 1 — December 31, 2007 Annual Report 2007 31 DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status PFIZER CANADA INC. (continued) 02239767 VIAGRA - 50MG/TAB sildenafil citrate G04BE tablet Within Guidelines 02239768 VIAGRA - 100MG/TAB sildenafil citrate G04BE tablet Within Guidelines 02238618 VIRACEPT - 50MG/G nelfinavir mesylate J05AE powder for oral suspension not sold No Current Sales 02238617 VIRACEPT - 250MG/TAB nelfinavir mesylate J05AE tablet Within Guidelines 02248761 VIRACEPT - 625MG/TAB nelfinavir mesylate J05AE tablet Within Guidelines 02240509 VISTIDE - 75MG/ML cidofovir J05AB injectable solution not sold No Current Sales 02246619 XALACOM latanoprost/timolol maleate S01ED ophthalmic solution Within Guidelines 02231493 XALATAN - 0.05MG/ML latanoprost S01EE ophthalmic solution Within Guidelines 02298597 ZELDOX - 20MG/CAP ziprasidone hydrochloride N05AE capsule not sold No Current Sales 02298600 ZELDOX - 40MG/CAP ziprasidone hydrochloride N05AE capsule not sold No Current Sales 02298619 ZELDOX - 60MG/CAP ziprasidone hydrochloride N05AE capsule not sold No Current Sales 02298627 ZELDOX - 80MG/CAP ziprasidone hydrochloride N05AE capsule not sold No Current Sales 02153432 ZINECARD - 250MG/VIAL dexrazoxane V03AF powder for injectable solution Within Guidelines 02153440 ZINECARD - 500MG/VIAL dexrazoxane V03AF powder for injectable solution Within Guidelines 02091291 ZITHROMAX - 250MG/CAP azithromycin J01FA capsule not sold No Current Sales 02223716 ZITHROMAX - 20MG/ML azithromycin J01FA powder for oral suspension Within Guidelines 02223724 ZITHROMAX - 40MG/ML azithromycin J01FA powder for oral suspension Within Guidelines 02229971 ZITHROMAX - 1000MG/POUCH azithromycin J01FA powder for oral solution not sold No Current Sales 02212021 ZITHROMAX - 250MG/TAB azithromycin J01FA tablet Within Guidelines 02247748 ZITHROMAX - 500MG/TAB azithromycin J01FA tablet not sold No Current Sales 02231143 ZITHROMAX - 600MG/TAB azithromycin J01FA tablet Within Guidelines 02239952 ZITHROMAX - 500MG/VIAL azithromycin J01FA powder for injectable solution Within Guidelines 02132702 ZOLOFT - 25MG/CAP sertraline hydrochloride N06AB capsule Within Guidelines 01962817 ZOLOFT - 50MG/CAP sertraline hydrochloride N06AB capsule Within Guidelines 01962779 ZOLOFT - 100MG/CAP sertraline hydrochloride N06AB capsule Within Guidelines 01962787 ZOLOFT - 150MG/CAP sertraline hydrochloride N06AB capsule not sold No Current Sales 01962795 ZOLOFT - 200MG/CAP sertraline hydrochloride N06AB capsule not sold No Current Sales 02243685 ZYVOXAM - 2MG/ML linezolid J01XX injectable solution Within Guidelines 02243686 ZYVOXAM - 20MG/ML linezolid J01XX powder for oral suspension not sold No Current Sales 02243683 ZYVOXAM - 400MG/TAB linezolid J01XX tablet not sold No Current Sales 02243684 ZYVOXAM - 600MG/TAB linezolid J01XX tablet Within Guidelines

PHARMACEUTICAL PARTNERS OF CANADA INC. 02246597 PAMIDRONATE DISODIUM - 30MG/VIAL pamidronate disodium M05BA injectable solution Within Guidelines 02246598 PAMIDRONATE DISODIUM - 60MG/VIAL pamidronate disodium M05BA injectable solution Within Guidelines 02246599 PAMIDRONATE DISODIUM - 90MG/VIAL pamidronate disodium M05BA injectable solution Within Guidelines

PHARMASCIENCE INC. 02242473 ATRIDOX - 44MG/DOSE doxycycline hyclate A01AB subgingival gel Subj. Investigation

PREMPHARM INC. 02229437 PHOSLO - 667MG/TAB calcium acetate V03AE tablet Subj. Investigation

PROCTER & GAMBLE PHARMACEUTICALS CANADA INC. 02242518 ACTONEL - 5MG/TAB risedronate sodium M05BA tablet Within Guidelines 02239146 ACTONEL - 30MG/TAB risedronate sodium M05BA tablet Within Guidelines 02246896 ACTONEL - 35MG/TAB risedronate sodium M05BA tablet Within Guidelines 02297787 ACTONEL - 75MG/TAB risedronate sodium M05BA tablet introduced Within Guidelines 02279657 ACTONEL PLUS CALCIUM risedronate sodium+calcium carbonate M05BA tablet Within Guidelines 01997580 ASACOL - 400MG/TAB mesalamine A07EC tablet Within Guidelines www.pmprb-cepmb.gc.ca

32 Canadian Patentees and Patented Drug Products for Human Use DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status PROCTER & GAMBLE PHARMACEUTICALS CANADA INC. (continued) 02267217 ASACOL 800 - 800MG/TAB mesalamine A07EC delayed-release tablet Within Guidelines 02231062 CREST GUM CARE - 4.54MG/G stannous fluoride A01AA toothpaste not sold No Current Sales 02176017 DIDROCAL etidronate disodium and calcium carbonate M05BB tablet Within Guidelines 02063662 MACROBID - 100MG/CAP nitrofurantoin J01XE capsule Within Guidelines

PURDUE PHARMA 02163756 GASTROBID - 20MG/TAB metoclopramide hydrochloride A03FA sustained-release tablet not sold No Current Sales 02125323 HYDROMORPH CONTIN - 3MG/CAP hydromorphone hydrochloride N02AA sustained-release capsule Within Guidelines 02125331 HYDROMORPH CONTIN - 6MG/CAP hydromorphone hydrochloride N02AA sustained-release capsule Within Guidelines 02125358 HYDROMORPH CONTIN - 10MG/CAP hydromorphone hydrochloride N02AA sustained-release capsule not sold No Current Sales 02125366 HYDROMORPH CONTIN - 12MG/CAP hydromorphone hydrochloride N02AA sustained-release capsule Within Guidelines 02243562 HYDROMORPH CONTIN - 18MG/CAP hydromorphone hydrochloride N02AA sustained-release capsule Within Guidelines 02125374 HYDROMORPH CONTIN - 20MG/CAP hydromorphone hydrochloride N02AA sustained-release capsule not sold No Current Sales 02125382 HYDROMORPH CONTIN - 24MG/CAP hydromorphone hydrochloride N02AA sustained-release capsule Within Guidelines 02125390 HYDROMORPH CONTIN - 30MG/CAP hydromorphone hydrochloride N02AA sustained-release capsule Within Guidelines 02146827 MS CONTIN - 30MG/SUP morphine sulfate N02AA sustained-release suppository not sold No Current Sales 02145944 MS CONTIN - 60MG/SUP morphine sulfate N02AA sustained-release suppository not sold No Current Sales 02145952 MS CONTIN - 100MG/SUP morphine sulfate N02AA sustained-release suppository not sold No Current Sales 02145960 MS CONTIN - 200MG/SUP morphine sulfate N02AA sustained-release suppository not sold No Current Sales 02145979 MS CONTIN - 300MG/SUP morphine sulfate N02AA sustained-release suppository not sold No Current Sales 02242827 MS CONTIN XL - 30MG/CAP morphine sulfate N02AA sustained-release capsule not sold No Current Sales 02242828 MS CONTIN XL - 60MG/CAP morphine sulfate N02AA sustained-release capsule not sold No Current Sales 02242829 MS CONTIN XL - 90MG/CAP morphine sulfate N02AA sustained-release capsule not sold No Current Sales 02242830 MS CONTIN XL - 120MG/CAP morphine sulfate N02AA sustained-release capsule not sold No Current Sales 02242831 MS CONTIN XL - 150MG/CAP morphine sulfate N02AA sustained-release capsule not sold No Current Sales 02242832 MS CONTIN XL - 200MG/CAP morphine sulfate N02AA sustained-release capsule not sold No Current Sales 02258129 OXYCONTIN - 5MG/TAB oxycodone hydrochloride N02AA controlled-release tablet Within Guidelines 02202441 OXYCONTIN - 10MG/TAB oxycodone hydrochloride N02AA controlled-release tablet Within Guidelines 02202468 OXYCONTIN - 20MG/TAB oxycodone hydrochloride N02AA controlled-release tablet Within Guidelines 02202476 OXYCONTIN - 40MG/TAB oxycodone hydrochloride N02AA controlled-release tablet Within Guidelines 02202484 OXYCONTIN - 80MG/TAB oxycodone hydrochloride N02AA controlled-release tablet Within Guidelines 02246902 OXYCONTIN - 160MG/TAB oxycodone hydrochloride N02AA controlled-release tablet not sold No Current Sales 02243159 PALLADONE XL - 12MG/CAP hydromorphone hydrochloride N02AA controlled-release capsule not sold No Current Sales 02243160 PALLADONE XL - 16MG/CAP hydromorphone hydrochloride N02AA controlled-release capsule not sold No Current Sales 02243161 PALLADONE XL - 24MG/CAP hydromorphone hydrochloride N02AA controlled-release capsule not sold No Current Sales 02243162 PALLADONE XL - 32MG/CAP hydromorphone hydrochloride N02AA controlled-release capsule not sold No Current Sales 02286424 ZYTRAM XL - 150MG/TAB tramadol hydrochloride N02AX controlled-release tablet introduced (nas) Under Review 02286432 ZYTRAM XL - 200MG/TAB tramadol hydrochloride N02AX controlled-release tablet introduced (nas) Under Review 02286440 ZYTRAM XL - 300MG/TAB tramadol hydrochloride N02AX controlled-release tablet introduced (nas) Under Review 02286459 ZYTRAM XL - 400MG/TAB tramadol hydrochloride N02AX controlled-release tablet introduced (nas) Under Review

RARE DISEASE THERAPEUTICS INC. ORFADIN - 2MG/CAP nitisinone A16AX capsule Within Guidelines ORFADIN - 5MG/CAP nitisinone A16AX capsule Within Guidelines ORFADIN - 10MG/CAP nitisinone A16AX capsule Within Guidelines

RATIOPHARM 02128845 KENRAL-FLUOXETINE - 10MG/CAP fluoxetine hydrochloride N06AB capsule expired No Current Sales 02128853 KENRAL-FLUOXETINE - 20MG/CAP fluoxetine hydrochloride N06AB capsule expired No Current Sales 00878790 RATIO-FLUNISOLIDE - 0.25MG/ML flunisolide R01AD nasal aerosol Subj. Investigation 02244914 RATIO-SALBUTAMOL HFA - 0.1MG/DOSE salbutamol sulfate R03AC aerosol for inhalation Subj. Investigation www.pmprb-cepmb.gc.ca

January 1 — December 31, 2007 Annual Report 2007 33 DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status RGR PHARMA LTD. 02244533 MAXILENE 4 - 40MG/G lidocaine D04AB topical anesthetic cream Within Guidelines 02245939 MAXILENE 5 - 50MG/G lidocaine D04AB topical anesthetic cream Within Guidelines

SANOFI PASTEUR LIMITED 02240255 ADACEL DaPT vaccine J07AJ injectable suspension Within Guidelines 02247208 DUKORAL vaccine cholera toxin B subunit (rDNA) J07AE oral vaccine Subj. Investigation 02243167 PEDIACEL DaPT-IPV-Hib vaccine J07CA injectable suspension introduced Within Guidelines 02231343 PENTACEL DaPT-IPV-Hib vaccine J07CA injectable suspension Notice of Hearing 02230946 QUADRACEL DaPT-IPV vaccine J07CA injectable suspension Notice of Hearing

SANOFI-AVENTIS CANADA INC. 02231463 ALLEGRA - 60MG/CAP fexofenadine hydrochloride R06AX capsule not sold No Current Sales 02231462 ALLEGRA - 60MG/TAB fexofenadine hydrochloride R06AX tablet Within Guidelines 02242819 ALLEGRA - 120MG/TAB fexofenadine hydrochloride R06AX tablet Within Guidelines 02239853 ALLEGRA-D 60/120 fexofenadine hydrochloride/pseudoephedrine R01BA sustained-release tablet Within Guidelines hydrochloride 02221829 ALTACE - 1.25MG/CAP ramipril C09AA capsule Within Guidelines 02221837 ALTACE - 2.5MG/CAP ramipril C09AA capsule Within Guidelines 02221845 ALTACE - 5MG/CAP ramipril C09AA capsule Within Guidelines 02221853 ALTACE - 10MG/CAP ramipril C09AA capsule Within Guidelines 02281112 ALTACE - 15MG/CAP ramipril C09AA capsule Within Guidelines 02248052 ALTACE - 1.25MG/TAB ramipril C09AA tablet not sold No Current Sales 02248053 ALTACE - 2.5MG/TAB ramipril C09AA tablet not sold No Current Sales 02248054 ALTACE - 5MG/TAB ramipril C09AA tablet not sold No Current Sales 02248055 ALTACE - 10MG/TAB ramipril C09AA tablet not sold No Current Sales 02283166 ALTACE HCT 10/12.5 ramipril/hydrochlorothiazide C09BA tablet Within Guidelines 02283182 ALTACE HCT 10/25 ramipril/hydrochlorothiazide C09BA tablet Within Guidelines 02283131 ALTACE HCT 2.5/12.5 ramipril/hydrochlorothiazide C09BA tablet Within Guidelines 02283158 ALTACE HCT 5/12.5 ramipril/hydrochlorothiazide C09BA tablet Within Guidelines 02283174 ALTACE HCT 5/25 ramipril/hydrochlorothiazide C09BA tablet Within Guidelines 02240307 ALTACE PLUS FELODIPINE 2.5/2. felodipine/ramipril C09BB sustained-release tablet not sold No Current Sales 02240306 ALTACE PLUS FELODIPINE 5/5 felodipine/ramipril C09BB sustained-release tablet not sold No Current Sales 02231380 ANZEMET - 20MG/ML dolasetron mesylate A04AA injectable solution Within Guidelines 02231378 ANZEMET - 50MG/TAB dolasetron mesylate A04AA tablet Within Guidelines 02231379 ANZEMET - 100MG/TAB dolasetron mesylate A04AA tablet Within Guidelines 02241888 ARAVA - 10MG/TAB leflunomide L04AA tablet Within Guidelines 02241889 ARAVA - 20MG/TAB leflunomide L04AA tablet Within Guidelines 02241890 ARAVA - 100MG/TAB leflunomide L04AA tablet not sold No Current Sales 02225085 CLAFORAN - 500MG/VIAL cefotaxime sodium J01DA powder for injectable solution Within Guidelines 02225093 CLAFORAN - 1000MG/VIAL cefotaxime sodium J01DA powder for injectable solution Within Guidelines 02225107 CLAFORAN - 2000MG/VIAL cefotaxime sodium J01DA powder for injectable solution Within Guidelines 00839248 CLAFORAN ADD-VANTAGE - 1000MG/VIAL cefotaxime sodium J01DA powder for injectable solution not sold No Current Sales 00839256 CLAFORAN ADD-VANTAGE - 2000MG/VIAL cefotaxime sodium J01DA powder for injectable solution not sold No Current Sales 02248239 ELIGARD - 7.5MG/VIAL leuprolide acetate L02AE injectable solution Within Guidelines 02248240 ELIGARD - 22.5MG/VIAL leuprolide acetate L02AE injectable solution Within Guidelines 02248999 ELIGARD - 30MG/VIAL leuprolide acetate L02AE injectable solution Within Guidelines 02268892 ELIGARD - 45MG/VIAL leuprolide acetate L02AE injectable solution Subj. Investigation 02296284 ELOXATIN - 5MG/ML oxaliplatin L01XA injectable solution Within Guidelines ELOXATIN - 50MG/VIAL oxaliplatin L01XA powder for injectable solution not sold VCU ELOXATIN - 100MG/VIAL oxaliplatin L01XA powder for injectable solution not sold VCU 02248416 FASTURTEC - 1.5MG/VIAL rasburicase V03AF powder for injectable solution Within Guidelines www.pmprb-cepmb.gc.ca

34 Canadian Patentees and Patented Drug Products for Human Use DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status SANOFI-AVENTIS CANADA INC. (continued) 02271397 FASTURTEC - 7.5MG/VIAL rasburicase V03AF powder for injectable solution not sold No Current Sales 02247520 KETEK - 400MG/TAB telithromycin J01FA tablet Within Guidelines 02245689 LANTUS - 100UNIT/ML insulin glargine A10AE injectable solution Within Guidelines 02251930 LANTUS - 100UNIT/ML insulin glargine A10AE injectable solution VCU 02294338 LANTUS SOLOSTAR - 100UNIT/ML insulin glargine A10AE injectable solution not sold No Current Sales 02221802 LOPROX - 10MG/G ciclopirox olamine D01AE topical cream Within Guidelines 02221810 LOPROX - 10MG/ML ciclopirox olamine D01AE topical lotion Within Guidelines 02012472 LOVENOX - 100MG/ML enoxaparin sodium B01AB injectable solution Within Guidelines 02236564 LOVENOX - 100MG/ML enoxaparin sodium B01AB injectable solution Within Guidelines 02236883 LOVENOX - 100MG/ML enoxaparin sodium B01AB injectable solution Within Guidelines 02242692 LOVENOX HP - 150MG/ML enoxaparin sodium B01AB injectable solution Within Guidelines 02213834 NASACORT AQ - 55MCG/DOSE triamcinolone acetonide R01AD nasal spray Within Guidelines 02250535 PENLAC - 80MG/ML ciclopirox D01AE topical solution Notice of Hearing 02017709 PLAQUENIL - 200MG/TAB hydroxychloroquine sulfate P01BA tablet Within Guidelines 02221985 RENEDIL - 2.5MG/TAB felodipine C08CA sustained-release tablet Within Guidelines 02221993 RENEDIL - 5MG/TAB felodipine C08CA sustained-release tablet Within Guidelines 02222000 RENEDIL - 10MG/TAB felodipine C08CA sustained-release tablet Within Guidelines 02242763 RILUTEK - 50MG/TAB riluzole N07XX tablet Within Guidelines 02068028 SABRIL - 1000MG/POUCH vigabatrin N03AG powder for oral solution not sold No Current Sales 02068001 SABRIL - 2000MG/POUCH vigabatrin N03AG powder for oral solution not sold No Current Sales 02067994 SABRIL - 3000MG/POUCH vigabatrin N03AG powder for oral solution not sold No Current Sales 00590908 SELDANE - 60MG/TAB terfenadine R06AX tablet not sold No Current Sales 00786624 SELDANE - 120MG/TAB terfenadine R06AX tablet not sold No Current Sales 02230643 SKELID - 200MG/TAB tiludronate disodium M05BA tablet not sold No Current Sales 02195976 SUPRAX - 200MG/TAB cefixime J01DA tablet not sold No Current Sales 02195984 SUPRAX - 400MG/TAB cefixime J01DA tablet Subj. Investigation 02177099 TAXOTERE - 20MG/VIAL docetaxel L01CD injectable solution Within Guidelines 02177080 TAXOTERE - 80MG/VIAL docetaxel L01CD injectable solution Within Guidelines 00870927 TERFENADINE - 60MG/TAB terfenadine R06AX tablet not sold No Current Sales TERFENADINE - 120MG/TAB terfenadine R06AX tablet not sold No Current Sales 02245565 XATRAL - 10MG/TAB alfuzosin hydrochloride G04CA sustained-release tablet Within Guidelines

SCHEIN PHARMACEUTICAL CANADA INC. 02241598 SCHEINPHARM RANITIDINE - 150MG/TAB ranitidine hydrochloride A02BA tablet not sold No Current Sales 02241599 SCHEINPHARM RANITIDINE - 300MG/TAB ranitidine hydrochloride A02BA tablet not sold No Current Sales

SCHERING-PLOUGH CANADA INC. 02243919 AERIUS - 5MG/TAB desloratadine R06AX tablet Within Guidelines 02247192 AERIUS KIDS - 0.5MG/ML desloratadine R06AX syrup not sold No Current Sales 02247193 AERIUS KIDS - 0.5MG/ML desloratadine R06AX syrup not sold No Current Sales 02243021 ASMANEX - 0.2MG/DOSE mometasone furoate R01AD powder for inhalation not sold No Current Sales 02243022 ASMANEX - 0.4MG/DOSE mometasone furoate R01AD powder for inhalation not sold No Current Sales 02238389 CAELYX - 2MG/ML doxorubicin hydrochloride L01DB injectable solution Within Guidelines 02165465 CEDAX - 200MG/CAP ceftibuten J01DA capsule not sold No Current Sales 02165473 CEDAX - 400MG/CAP ceftibuten J01DA capsule not sold No Current Sales 02165449 CEDAX - 18MG/ML ceftibuten J01DA powder for oral suspension not sold No Current Sales 02165457 CEDAX - 36MG/ML ceftibuten J01DA powder for oral suspension not sold No Current Sales 01970399 CHLOR-TRIPOLON N.D. 5/120 loratadine/pseudoephedrine sulfate R06AX sustained-release tablet expired Within Guidelines 02019973 CLARITIN - 1MG/ML loratadine R06AX syrup expired No Current Sales 00782696 CLARITIN - 10MG/TAB loratadine R06AX tablet expired Within Guidelines www.pmprb-cepmb.gc.ca

January 1 — December 31, 2007 Annual Report 2007 35 DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status SCHERING-PLOUGH CANADA INC. (continued) 02260557 CLARITIN ALLERGY & SINUS 10/2 - loratadine/pseudoephedrine sulfate R01BA extended-release caplet Subj. Investigation 250MG/CPL 02237734 CLARITIN AXELERIS - 10MG/TAB loratadine R06AX tablet expired No Current Sales 01945157 CLARITIN EXTRA 5/120 loratadine/pseudoephedrine sulfate R01BA sustained-release tablet expired Within Guidelines 02241523 CLARITIN KIDS - 1MG/ML loratadine R06AX syrup expired Within Guidelines 02244941 CLARITIN LIBERATOR 10/240 loratadine/pseudoephedrine sulfate R01BA extended-release tablet not sold No Current Sales 00851744 ELOCOM - 1MG/G mometasone furoate D07XC cream Within Guidelines 00871095 ELOCOM - 1MG/ML mometasone furoate D07XC lotion Within Guidelines 02240351 INTEGRILIN - 0.75MG/ML eptifibatide B01AC injectable solution Within Guidelines 02240352 INTEGRILIN - 2MG/ML eptifibatide B01AC injectable solution Within Guidelines 02238674 INTRON-A HSA FREE - 6000000UNIT/ML interferon alfa-2b L03AB injectable solution Within Guidelines 02238675 INTRON-A HSA FREE - 10000000UNIT/ML interferon alfa-2b L03AB injectable solution Within Guidelines 02240693 INTRON-A PEN HSA FREE - 15000000UNIT/ML interferon alfa-2b L03AB injectable solution Within Guidelines 02240694 INTRON-A PEN HSA FREE - 25000000UNIT/ML interferon alfa-2b L03AB injectable solution Within Guidelines 02240695 INTRON-A PEN HSA FREE - 50000000UNIT/ML interferon alfa-2b L03AB injectable solution Within Guidelines 00713376 K-DUR 20 - 1500MG/TAB potassium chloride A12BA sustained-release tablet expired Subj. Investigation 02230921 LEUCOMAX - 0.15MG/VIAL molgramostim L03AA powder for injectable solution not sold No Current Sales 02230922 LEUCOMAX - 0.3MG/VIAL molgramostim L03AA powder for injectable solution not sold No Current Sales 02230923 LEUCOMAX - 0.4MG/VIAL molgramostim L03AA powder for injectable solution not sold No Current Sales 02230924 LEUCOMAX - 0.7MG/VIAL molgramostim L03AA powder for injectable solution not sold No Current Sales 02241211 MELACINE melanoma theraccine L03AX powder for injectable solution not sold No Current Sales 02238465 NASONEX - 0.05MG/DOSE mometasone furoate monohydrate R01AD nasal spray Within Guidelines 00503363 NETROMYCIN - 25MG/ML netilmicin sulfate J01GB injectable solution expired No Current Sales 00503371 NETROMYCIN - 50MG/ML netilmicin sulfate J01GB injectable solution expired No Current Sales 00503398 NETROMYCIN - 100MG/ML netilmicin sulfate J01GB injectable solution expired No Current Sales 01911910 NITRO-DUR 0.2 - 40MG/PATCH nitroglycerin C01DA transdermal patch expired Subj. Investigation 02213370 NITRO-DUR 0.3 - 60MG/PATCH nitroglycerin C01DA transdermal patch expired No Current Sales 01911902 NITRO-DUR 0.4 - 80MG/PATCH nitroglycerin C01DA transdermal patch expired No Current Sales 01911929 NITRO-DUR 0.6 - 120MG/PATCH nitroglycerin C01DA transdermal patch expired No Current Sales 02011271 NITRO-DUR 0.8 - 160MG/PATCH nitroglycerin C01DA transdermal patch expired No Current Sales 02246028 PEGETRON 100 peginterferon alfa-2b + ribavirin L03AB injectable solution + capsule Within Guidelines 02246029 PEGETRON 120 peginterferon alfa-2b + ribavirin L03AB injectable solution + capsule Within Guidelines 02246030 PEGETRON 150 peginterferon alfa-2b + ribavirin L03AB injectable solution + capsule Within Guidelines 02246026 PEGETRON 50 peginterferon alfa-2b + ribavirin L03AB injectable solution + capsule Within Guidelines 02246027 PEGETRON 80 peginterferon alfa-2b + ribavirin L03AB injectable solution + capsule Within Guidelines 02254603 PEGETRON REDIPEN 100 peginterferon alfa-2b + ribavirin L03AB injectable solution + capsule Within Guidelines 02254638 PEGETRON REDIPEN 120 peginterferon alfa-2b + ribavirin L03AB injectable solution + capsule Within Guidelines 02254646 PEGETRON REDIPEN 150 peginterferon alfa-2b + ribavirin L03AB injectable solution + capsule Within Guidelines 02254581 PEGETRON REDIPEN 80 peginterferon alfa-2b + ribavirin L03AB injectable solution + capsule Within Guidelines 02239730 REBETRON interferon alfa-2b + ribavirin J05AB injectable solution + capsule not sold No Current Sales 02241159 REBETRON PEN interferon alfa-2b + ribavirin J05AB injectable solution + capsule not sold No Current Sales 02244016 REMICADE - 100MG/VIAL infliximab L04AA powder for injectable solution Within Guidelines 02293404 SPRIAFIL - 40MG/ML posaconazole J02AC oral suspension introduced (nas) Within Guidelines 02241093 TEMODAL - 5MG/CAP temozolomide L01AX capsule Within Guidelines 02241094 TEMODAL - 20MG/CAP temozolomide L01AX capsule Within Guidelines 02241095 TEMODAL - 100MG/CAP temozolomide L01AX capsule Within Guidelines 02241096 TEMODAL - 250MG/CAP temozolomide L01AX capsule Within Guidelines 02242968 UNITRON-PEG 120 peginterferon alfa-2b L03AB powder for injectable suspension Within Guidelines 02242969 UNITRON-PEG 150 peginterferon alfa-2b L03AB powder for injectable suspension Within Guidelines 02242966 UNITRON-PEG 50 peginterferon alfa-2b L03AB powder for injectable suspension Within Guidelines 02242967 UNITRON-PEG 80 peginterferon alfa-2b L03AB powder for injectable suspension Within Guidelines www.pmprb-cepmb.gc.ca

36 Canadian Patentees and Patented Drug Products for Human Use DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status SCHERING-PLOUGH CANADA INC. (continued) 02248983 UNITRON-PEG PEN 100 peginterferon alfa-2b L03AB powder for injectable suspension not sold No Current Sales 02248984 UNITRON-PEG PEN 120 peginterferon alfa-2b L03AB powder for injectable suspension not sold No Current Sales 02248985 UNITRON-PEG PEN 150 peginterferon alfa-2b L03AB powder for injectable suspension not sold No Current Sales 02248981 UNITRON-PEG PEN 50 peginterferon alfa-2b L03AB powder for injectable suspension not sold No Current Sales 02248982 UNITRON-PEG PEN 80 peginterferon alfa-2b L03AB powder for injectable suspension not sold No Current Sales

SERVIER CANADA INC. 02123274 COVERSYL - 2MG/TAB perindopril erbumine C09AA tablet Within Guidelines 02270552 COVERSYL - 2.5MG/TAB perindopril arginine C09AA tablet not sold No Current Sales 02123282 COVERSYL - 4MG/TAB perindopril erbumine C09AA tablet Within Guidelines 02270560 COVERSYL - 5MG/TAB perindopril arginine C09AA tablet not sold No Current Sales 02246624 COVERSYL - 8MG/TAB perindopril erbumine C09AA tablet Within Guidelines 02270579 COVERSYL - 10MG/TAB perindopril arginine C09AA tablet not sold No Current Sales 02246569 COVERSYL PLUS 4/1.25 perindopril erbumine/indapamide C09BA tablet Within Guidelines 02246568 COVERSYL PLUS LD 2/0.625 perindopril erbumine/indapamide C09BA tablet Within Guidelines 02242987 DIAMICRON MR - 30MG/TAB gliclazide A10BB sustained-release tablet Subj. Investigation 02242219 STARNOC - 5MG/CAP zaleplon N05CF capsule expired No Current Sales 02242220 STARNOC - 10MG/CAP zaleplon N05CF capsule expired No Current Sales

SHIRE CANADA INC. 02248808 ADDERALL XR - 5MG/CAP mixed salts amphetamine N06BA extended-release capsule Notice of Hearing 02248809 ADDERALL XR - 10MG/CAP mixed salts amphetamine N06BA extended-release capsule Notice of Hearing 02248810 ADDERALL XR - 15MG/CAP mixed salts amphetamine N06BA extended-release capsule Notice of Hearing 02248811 ADDERALL XR - 20MG/CAP mixed salts amphetamine N06BA extended-release capsule Notice of Hearing 02248812 ADDERALL XR - 25MG/CAP mixed salts amphetamine N06BA extended-release capsule Notice of Hearing 02248813 ADDERALL XR - 30MG/CAP mixed salts amphetamine N06BA extended-release capsule Notice of Hearing 02239665 ALERTEC - 100MG/TAB modafinil N06BA tablet Within Guidelines 02238162 DIASTAT - 5MG/ML diazepam N05BA rectal gel Subj. Investigation 02287145 FOSRENOL - 250MG/TAB lanthanum carbonate hydrate V03AE chewable tablet introduced (nas) Within Guidelines 02287153 FOSRENOL - 500MG/TAB lanthanum carbonate hydrate V03AE chewable tablet introduced (nas) Within Guidelines 02287161 FOSRENOL - 750MG/TAB lanthanum carbonate hydrate V03AE chewable tablet introduced (nas) Within Guidelines 02287188 FOSRENOL - 1000MG/TAB lanthanum carbonate hydrate V03AE chewable tablet introduced (nas) Within Guidelines 02123320 PERMAX - 0.05MG/TAB pergolide mesylate N04BC tablet Within Guidelines 02123339 PERMAX - 0.25MG/TAB pergolide mesylate N04BC tablet Within Guidelines 02123347 PERMAX - 1MG/TAB pergolide mesylate N04BC tablet Within Guidelines 02245328 ZANAFLEX - 2MG/TAB tizanidine hydrochloride M03BX tablet not sold No Current Sales 02239170 ZANAFLEX - 4MG/TAB tizanidine hydrochloride M03BX tablet Within Guidelines

SHIRE HUMAN GENETIC THERAPIES INC. 02249057 REPLAGAL - 3.5MG/VIAL agalsidase alfa A16AB injectable solution introduced (nas) Within Guidelines

SOLVAY PHARMA INC. 02249499 ANDROGEL 1% - 1.25GM/DOSE testosterone G03BA topical gel introduced Subj. Investigation 02245345 ANDROGEL 1% - 2.5GM/POUCH testosterone G03BA topical gel introduced Subj. Investigation 02245346 ANDROGEL 1% - 5GM/POUCH testosterone G03BA topical gel introduced Within Guidelines 01950592 DICETEL - 50MG/TAB pinaverium bromide A03AX tablet Within Guidelines 02230684 DICETEL - 100MG/TAB pinaverium bromide A03AX tablet Within Guidelines 02292165 DUODOPA 20/5 levodopa/carbidopa N04BA injectable intestinal gel not sold No Current Sales 02269562 INFLUVAC - 15MCG/SYRINGE influenza vaccine, inactivated J07BB injectable suspension Within Guidelines 02240431 TEVETEN - 300MG/TAB eprosartan mesylate C09CA tablet not sold No Current Sales www.pmprb-cepmb.gc.ca

January 1 — December 31, 2007 Annual Report 2007 37 DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status SOLVAY PHARMA INC. (continued) 02240432 TEVETEN - 400MG/TAB eprosartan mesylate C09CA tablet Within Guidelines 02243942 TEVETEN - 600MG/TAB eprosartan mesylate C09CA tablet Within Guidelines 02253631 TEVETEN PLUS eprosartan mesylate/hydrochlorothiazide C09DA tablet Within Guidelines

SOPHERION THERAPEUTICS INC. 02245015 MYOCET doxorubicin hydrochloride, liposomal L01DB powder for injectable solution Within Guidelines

STIEFEL CANADA INC. 02243158 CLINDOXYL 1/5 clindamycin phosphate/benzoyl peroxide D10AF topical gel Under Review 02242919 ROSASOL - 10MG/G metronidazole D06BX topical cream Within Guidelines

TALECRIS BIOTHERAPEUTICS INC. 02204592 PROLASTIN - 25MG/ML alpha1-proteinase B02AB powder for injectable solution not sold No Current Sales 02204606 PROLASTIN - 25MG/ML alpha1-proteinase B02AB powder for injectable solution Subj. Investigation

TEVA NEUROSCIENCE G.P.-S.E.N.C. 02284642 AZILECT - 0.5MG/TAB rasagiline mesylate N04BD tablet Subj. Investigation 02284650 AZILECT - 1MG/TAB rasagiline mesylate N04BD tablet Subj. Investigation 02245619 COPAXONE - 20MG/SYRINGE glatiramer acetate L03AX injectable solution Notice of Hearing 02233014 COPAXONE - 20MG/VIAL glatiramer acetate L03AX powder for injectable solution not sold No Current Sales 02257084 FROVA - 2.5MG/TAB frovatriptan succinate N02CC tablet not sold No Current Sales

THERAMED CORPORATION 02241323 SYNERCID 150/350 quinupristin/dalfopristin J01FG powder for injectable solution expired No Current Sales

THREE RIVERS PHARMACEUTICALS 02241750 AMPHOTEC - 50MG/VIAL amphotericin B lipid complex J02AA powder for injectable solution not sold Under Review 02241749 AMPHOTEC - 100MG/VIAL amphotericin B lipid complex J02AA powder for injectable solution not sold Under Review

TYCO HEALTHCARE GROUP CANADA INC. 02242986 OPTIMARK - 330.9MG/ML gadoversetamide V08CA injectable solution Within Guidelines

UNITHER BIOTECH INC. 02246552 REMODULIN - 1MG/ML treprostinil sodium B01AC injectable solution Within Guidelines 02246553 REMODULIN - 2.5MG/ML treprostinil sodium B01AC injectable solution Within Guidelines 02246554 REMODULIN - 5MG/ML treprostinil sodium B01AC injectable solution Within Guidelines 02246555 REMODULIN - 10MG/ML treprostinil sodium B01AC injectable solution Within Guidelines

VALEANT CANADA LTD. 02239832 INFERGEN - 0.03MG/ML interferon alfacon-1 L03AB injectable solution Within Guidelines 02268272 XYREM - 500MG/ML sodium oxybate N07XX oral solution introduced (nas) Subj. Investigation WYETH PHARMACEUTICALS 02231018 BENEFIX - 250UNIT/VIAL coagulation factor IX (recombinant) B02BD powder for injectable solution not sold No Current Sales 02293765 BENEFIX - 250UNIT/VIAL coagulation factor IX (recombinant) B02BD powder for injectable solution not sold No Current Sales 02231019 BENEFIX - 500UNIT/VIAL coagulation factor IX (recombinant) B02BD powder for injectable solution Within Guidelines 02293773 BENEFIX - 500UNIT/VIAL coagulation factor IX (recombinant) B02BD powder for injectable solution not sold No Current Sales 02231020 BENEFIX - 1000UNIT/VIAL coagulation factor IX (recombinant) B02BD powder for injectable solution Within Guidelines 02293781 BENEFIX - 1000UNIT/VIAL coagulation factor IX (recombinant) B02BD powder for injectable solution introduced Within Guidelines www.pmprb-cepmb.gc.ca

38 Canadian Patentees and Patented Drug Products for Human Use DIN/GP Brand Name Generic Name ATC Dosage Form Comments Status WYETH PHARMACEUTICALS (continued) 02293803 BENEFIX - 2000UNIT/VIAL coagulation factor IX (recombinant) B02BD powder for injectable solution not sold No Current Sales 02237279 EFFEXOR XR - 37.5MG/CAP venlafaxine hydrochloride N06AA extended-release capsule Within Guidelines 02237280 EFFEXOR XR - 75MG/CAP venlafaxine hydrochloride N06AA extended-release capsule Within Guidelines 02237281 EFFEXOR XR - 100MG/CAP venlafaxine hydrochloride N06AA extended-release capsule not sold No Current Sales 02237282 EFFEXOR XR - 150MG/CAP venlafaxine hydrochloride N06AA extended-release capsule Within Guidelines 02126206 HIBTITER vaccine - Hemophilus influenzae B J07AG injectable suspension expired No Current Sales 01919644 MICRO-K LS - 1875MG/PCK potassium chloride A12BA oral suspension expired No Current Sales 02244081 PREVNAR pneumococcal 7-valent conjugate vaccine J07AL injectable solution expired Within Guidelines 02243237 RAPAMUNE - 1MG/ML sirolimus L04AA oral solution Within Guidelines 02247111 RAPAMUNE - 1MG/TAB sirolimus L04AA tablet Within Guidelines 02270617 RAPAMUNE - 2MG/TAB sirolimus L04AA tablet not sold No Current Sales 02270684 RAPAMUNE - 5MG/TAB sirolimus L04AA tablet not sold No Current Sales 02245949 REFACTO - 250UNIT/VIAL moroctocog alfa B02BD powder for injectable solution not sold No Current Sales 02245950 REFACTO - 500UNIT/VIAL moroctocog alfa B02BD powder for injectable solution not sold No Current Sales 02245951 REFACTO - 1000UNIT/VIAL moroctocog alfa B02BD powder for injectable solution not sold No Current Sales 02170817 TAZOCIN 2000/250 piperacillin sodium/tazobactam sodium J01CR powder for injectable solution Within Guidelines 02170795 TAZOCIN 3000/375 piperacillin sodium/tazobactam sodium J01CR powder for injectable solution Within Guidelines 02170809 TAZOCIN 4000/500 piperacillin sodium/tazobactam sodium J01CR powder for injectable solution Within Guidelines 02093405 TETRAMUNE DPT-Hemophilus B conjugate vaccine J07AG injectable suspension expired No Current Sales 02304104 TORISEL - 25MG/VIAL temsirolimus L01XE injectable solution not sold No Current Sales 02285401 TYGACIL - 50MG/VIAL tigecycline J01AA powder for injectable solution Within Guidelines www.pmprb-cepmb.gc.ca

January 1 — December 31, 2007 Annual Report 2007 39