Table 4 Selected early and late genes in adult Spo11-/- testes and juvenile wild-type testes

Average signal ratio Adult wild- 15dpp wild- Adult 15dpp type vs type vs Spo11 -/- vs Spo11 -/- vs reference adult wild- adult wild- 15dpp wild- GO/ Biological process ID Name RNA type type type

Cluster 1 regulation of transcription, DNA-dependent BG086576 ankyrin repeat and FYVE domain containing 1 0.45 1.94 2.76 1.29 induction of programmed cell death BG074245 pleiomorphic adenoma gene-like 2 0.79 1.95 2.72 1.10 induction of programmed cell death BG065030 glutathione peroxidase 1 0.37 1.25 5.23 0.85 regulation of transcription, DNA-dependent BG072554 ankyrin repeat domain 10 0.21 1.84 2.05 0.98 regulation of transcription, DNA-dependent BG075473 nuclear receptor subfamily 3, group C, member 1 0.76 1.16 2.87 1.15 regulation of cell cycle BG077774 v-abl Abelson murine leukemia oncogene 1 0.27 1.70 2.23 1.04 germ-cell development BG063365 chemokine (C-X-C motif) receptor 4 0.48 1.77 2.41 0.98 regulation of transcription, DNA-dependent BG087880 jumonji, AT rich interactive domain 1C (Rbp2 like) 0.37 1.90 3.07 1.27 fertilization (sensu Animalia) BG073671 milk fat globule-EGF factor 8 protein 0.52 1.42 2.90 0.98 regulation of transcription, DNA-dependent BG084537 replication factor C 1 0.64 1.86 2.55 0.80 regulation of cell cycle BG088254 BRCA2 and CDKN1A interacting protein 1.02 1.30 2.02 0.92 regulation of transcription, DNA-dependent BG085396 transforming growth factor beta 1 induced transcript 4 1.47 0.88 2.25 0.88 positive regulation of transcription BG088871 GATA binding protein 4 (Gata4), mRNA 1.97 1.36 2.34 0.94 DNA damage response, signal transduction resulting in cell cycle arrest BG070939 checkpoint kinase 1 homolog (S. pombe) 0.73 1.84 2.78 1.02 apoptosis BG064583 testis enhanced gene transcript 0.48 1.36 2.21 1.03 apoptosis BG064074 B-cell receptor-associated protein 31 0.44 1.55 2.35 1.46 apoptosis BG085048 caspase recruitment domain family, member 10 0.76 1.17 2.40 1.10 translational initiation BG070960 eukaryotic translation initiation factor 4, gamma 2 0.54 1.38 2.06 0.99 DNA repair BG071999 UV radiation resistance associated gene 0.68 1.62 2.29 0.95 regulation of transcription, DNA-dependent BG073938 single-stranded DNA binding protein 3 0.64 1.56 2.12 1.09 cell death BG072209 clusterin 8.21 1.60 4.50 1.15 anti-apoptosis BG084405 baculoviral IAP repeat-containing 3 0.91 1.11 2.05 1.06 regulation of transcription, DNA-dependent BG086687 transcriptional regulator, SIN3B (yeast) 4.22 1.41 3.08 0.93 regulation of transcription, DNA-dependent BG067190 ankyrin repeat domain 6 0.86 1.93 2.79 1.16 DNA repair BG075420 casein kinase 1, delta 0.34 1.37 2.08 0.82 regulation of transcription, DNA-dependent BG076902 purine rich element binding protein A 0.59 1.80 2.21 0.93 apoptosis BG088241 lymphocyte specific 1 0.34 1.86 2.71 1.07 regulation of transcription, DNA-dependent BG066379 jumonji domain containing 2A 0.21 1.96 4.82 1.25 regulation of transcription, DNA-dependent BG067918 B-cell translocation gene 2, anti-proliferative 0.33 1.35 2.26 1.31 apoptosis BG077957 programmed cell death 6 0.56 1.28 2.01 1.11 regulation of transcription from Pol II promoter BG087452 Wilms tumor homolog 0.32 1.96 3.40 1.20 germ-cell development BG087137 kit oncogene 2.69 1.15 3.90 1.19 regulation of transcription from Pol II promoter BG084377 signal transducer and activator of transcription 3 0.51 1.81 2.88 1.05 DNA repair BG067126 single-strand selective monofunctional uracil DNA glycosylase 0.88 1.40 2.22 2.19 positive regulation of transcription from Pol II promoter BG077765 SRY-box containing gene 8 0.51 1.41 2.84 1.04 spermatogenesis BG064308 acyl-Coenzyme A oxidase 1, palmitoyl 1.65 0.25 5.00 1.01 regulation of transcription, DNA-dependent BG074917 general transcription factor II I 0.72 1.43 2.79 1.15 regulation of transcription, DNA-dependent BG064455 longevity assurance homolog 6 (S. cerevisiae) 0.84 1.58 2.51 1.32 transcription BG075851 polymerase (RNA) II (DNA directed) polypeptide B 0.51 1.16 2.45 1.05 regulation of transcription, DNA-dependent BG085373 GLI-Kruppel family member GLI2 0.51 1.54 2.15 1.19 nuclear division BG071683 centromere autoantigen H 0.59 1.44 2.34 0.99 regulation of transcription, DNA-dependent BG066892 upstream regulatory element binding protein 1e 0.27 2.00 4.33 1.82 translational elongation BG083078 LanC (bacterial lantibiotic synthetase component C)-like 2 0.85 1.43 2.05 0.87 male sex determination BG069156 insulin-like growth factor I receptor 0.41 1.92 2.04 1.03 apoptosis BG081632 Janus kinase 2 0.69 1.38 2.03 0.89 regulation of transcription, DNA-dependent BG072106 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.79 1.60 2.13 0.90 disassembly of cell structures BG074045 superoxide dismutase 1, soluble 1.15 0.85 2.23 0.96 induction of programmed cell death BG073154 BCL2/adenovirus E1B 19kD interacting protein like 0.86 1.50 2.86 1.08 apoptosis BG086954 amyloid beta (A4) precursor protein 0.59 1.75 2.59 1.12 apoptosis BG085493 ubiquitin-activating enzyme E1C 0.34 1.76 4.35 1.12 regulation of transcription, DNA-dependent BG069856 cyclin C 0.57 1.31 2.19 0.98 regulation of transcription, DNA-dependent BG079354 nuclear receptor co-repressor 2 0.82 1.96 2.52 1.08 anti-apoptosis BG086150 craniofacial development protein 1 0.23 1.46 2.09 0.91 regulation of transcription BG066422 prostaglandin E synthase 2 0.81 1.26 2.46 1.04 nucleotide-excision repair BG073656 serine/threonine kinase 2 0.14 1.96 2.33 1.02 apoptosis BG067419 growth arrest and DNA-damage-inducible 45 gamma 0.53 1.22 2.07 1.11 induction of programmed cell death BG076240 caspase 6 1.02 1.47 2.22 1.11 regulation of transcription, DNA-dependent AW552582 deformed epidermal autoregulatory factor 1 (Drosophila) 0.70 1.65 2.10 1.15 regulation of transcription, DNA-dependent BG077537 RIKEN cDNA 0610009M14 gene 0.65 1.22 2.19 1.08 nuclear division BG086107 pescadillo homolog 1, containing BRCT domain (zebrafish) 0.94 1.98 2.86 0.88 regulation of transcription, DNA-dependent BG084078 jumonji, AT rich interactive domain 1A (Rbp2 like) 1.06 1.85 3.61 1.17 regulation of transcription, DNA-dependent BG075386 bobby sox homolog (Drosophila) 0.89 1.42 2.02 1.01 positive regulation of transcription from Pol II promoter BG073001 cellular nucleic acid binding protein 0.72 1.69 2.08 0.87 fertilization (sensu Animalia) BG075310 transketolase 0.16 1.57 3.16 0.90 binding of sperm to zona pellucida BG084869 RIKEN cDNA A430096B05 gene 0.64 1.74 3.29 1.31 regulation of transcription, DNA-dependent BG079235 cellular repressor of E1A-stimulated genes 0.72 1.40 2.84 0.93 regulation of transcription, DNA-dependent BG064318 retinoic acid induced 1 1.19 0.65 2.77 1.01 cytolysis BG077623 hypoxanthine guanine phosphoribosyl transferase 0.90 1.77 2.01 1.21 regulation of transcription BG064108 PDZ and LIM domain 1 (elfin) 0.30 1.45 2.83 0.80 regulation of transcription, DNA-dependent BG087132 ubiquitin specific protease 49 1.39 1.22 2.04 0.94 DNA repair AU021534 flap structure specific endonuclease 1 0.66 1.76 2.59 0.92 positive regulation of transcription from Pol II promoter BG067330 nuclear receptor subfamily 5, group A, member 1 1.16 1.60 2.83 1.40 translational elongation BG074911 ribosomal protein, large, P1 0.32 1.34 2.12 1.13 induction of programmed cell death BG082842 Bcl-2-related ovarian killer protein 0.49 1.58 2.05 1.01 regulation of transcription, DNA-dependent BG064695 RIKEN cDNA A830092L04 gene 0.64 1.59 2.30 0.92 negative regulation of cell cycle BG086151 CDK2 (cyclin-dependent kinase 2)-associated protein 1 0.63 1.46 2.16 0.91 regulation of transcription, DNA-dependent BG086994 RAB7, member RAS oncogene family 0.41 1.63 2.77 1.12 single strand break repair BG069854 X-ray repair complementing defective repair in Chinese hamster cells 1 0.77 1.56 3.48 1.25 regulation of transcription, DNA-dependent BG069095 interferon consensus sequence binding protein 1 0.91 0.88 2.50 0.96 cell cycle arrest BG086554 microtubule-actin crosslinking factor 1 0.56 1.68 3.30 1.27 S phase of mitotic cell cycle BG084969 origin recognition complex, subunit 2-like (S. cerevisiae) 1.09 1.29 2.02 1.03 DNA repair BG072232 three prime repair exonuclease 1 1.17 1.38 2.09 0.84 S phase of mitotic cell cycle BG081111 topoisomerase (DNA) I 0.62 1.81 2.42 1.03 regulation of transcription, DNA-dependent BG086680 longevity assurance homolog 4 (S. cerevisiae) 0.23 1.86 3.17 0.94 regulation of transcription, DNA-dependent BG072359 fumarylacetoacetate hydrolase 0.61 1.76 2.37 1.04 cytolysis BG067456 lysozyme 1.28 1.77 4.27 0.62 transcription from Pol I promoter BG086106 fibrillarin 0.80 1.89 2.62 1.08 regulation of transcription, DNA-dependent BG076024 enhancer of zeste homolog 1 (Drosophila) 1.11 1.28 2.14 1.09 sex differentiation BG087691 anti-Mullerian hormone type 2 receptor 2.79 1.35 2.99 1.01 cell cycle BG074262 telomeric repeat binding factor 2 0.94 1.78 2.62 1.15 positive regulation of transcription from Pol II promoter BG086322 activating transcription factor 4 0.19 1.54 2.05 0.80 regulation of transcription, DNA-dependent BG088708 nuclear factor, erythroid derived 2,-like 1 0.86 1.38 2.11 1.00 regulation of transcription, DNA-dependent BG078428 placentae and embryos oncofetal gene 0.80 1.45 2.97 0.99 regulation of transcription, DNA-dependent BG068772 AE binding protein 2 0.34 1.74 3.94 1.12 regulation of transcription, DNA-dependent BG076162 zinc finger protein 612 1.44 1.57 2.24 1.20 induction of programmed cell death BG086310 caspase 9 0.42 1.40 2.50 0.98 regulation of transcription, DNA-dependent BG063736 nemo like kinase 0.81 1.77 2.02 1.24 regulation of transcription, DNA-dependent BG075770 nuclear factor I/X 0.24 1.80 2.77 0.98 BG070803 Mnd1 2.41 0.93 5.92 4.57

Cluster 2 regulation of cell cycle BG083409 S100 calcium binding protein A6 (calcyclin) 0.08 2.27 2.33 0.97 DNA repair BG081657 alpha thalassemia/mental retardation syndrome X-linked homolog (human) 0.11 4.22 3.58 1.84 regulation of transcription, DNA-dependent BG085841 nuclear factor, erythroid derived 2, like 2 0.54 2.33 2.22 1.00 S phase of mitotic cell cycle BG073458 topoisomerase (DNA) II beta 0.50 2.57 2.11 0.97 regulation of transcription from Pol II promoter BG077260 DEK oncogene (DNA binding) 0.31 2.31 2.66 0.98 regulation of transcription, DNA-dependent BG080014 CREB binding protein 0.54 2.01 2.18 1.25 regulation of transcription, DNA-dependent BG085756 myocyte enhancer factor 2A 0.65 2.29 3.41 0.92 binding of sperm to zona pellucida BG084554 zona pellucida glycoprotein 3 7.27 2.20 4.13 1.04 negative regulation of transcription BG076894 MYB binding protein (P160) 1a 0.26 2.19 2.02 0.82 regulation of transcription, DNA-dependent BG071770 RIKEN cDNA 1110054N06 gene 0.41 2.30 5.60 0.84 regulation of transcription, DNA-dependent BG074668 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.19 3.67 5.07 1.09 regulation of transcription, DNA-dependent BG068596 RIKEN cDNA 9830141C09 gene 1.25 2.60 2.58 1.22 regulation of transcription, DNA-dependent BG079417 osteoclast stimulating factor 1 0.37 2.37 4.37 0.98 negative regulation of transcription BG074671 amino-terminal enhancer of split 0.39 2.08 4.47 0.92 induction of programmed cell death BG081793 mutS homolog 6 (E. coli) 0.65 2.01 2.93 0.95 apoptosis BG071892 RAD21 homolog (S. pombe) 0.43 2.36 2.67 1.01 cell cycle BG068738 spindlin 0.58 2.15 2.76 2.08 regulation of transcription, DNA-dependent BG085472 cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.17 3.39 3.97 0.95 cell cycle BG069285 mitogen activated protein kinase 1 0.33 2.38 5.84 1.10 female meiosis BG077849 protein phosphatase 1, catalytic subunit, alpha isoform 0.29 2.10 2.24 0.99 regulation of translation BG079420 pumilio 2 (Drosophila) 0.26 2.28 2.10 1.04 RNA elongation BG081444 transcription elongation factor A (SII) 1 0.31 2.82 2.08 0.93 regulation of translation BG087887 iron responsive element binding protein 2 0.73 3.05 4.07 0.95 regulation of transcription, DNA-dependent BG064719 RIKEN cDNA C730024G01 gene 0.55 2.01 2.80 0.74 fertilization (sensu Animalia) BG087410 CD9 antigen 0.16 2.37 2.53 0.98 apoptosis BG087162 BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP3 0.22 2.21 2.12 0.92 regulation of cell cycle BG064684 retroviral integration site 2 0.26 2.42 4.73 0.95 regulation of transcription, DNA-dependent BG069713 expressed sequence AI481750 0.74 2.37 2.41 1.54 cell cycle BG069959 DNA segment, Chr 5, ERATO Doi 606, expressed 0.14 4.26 2.37 0.99 regulation of transcription BG082429 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 4.62 2.18 2.35 1.16 disassembly of cell structures BG082930 programmed cell death 8 0.32 3.17 3.48 1.21 regulation of transcription, DNA-dependent BG080161 TAR DNA binding protein 0.99 2.34 3.34 0.74 induction of programmed cell death BG071986 apoptosis-associated speck-like protein containing a CARD 0.41 2.84 3.99 1.22 regulation of transcription, DNA-dependent BG084038 RIKEN cDNA 9230102N17 gene 0.49 3.21 2.48 1.10 transcription initiation BG073933 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor 0.12 2.49 3.54 1.14 regulation of transcription, DNA-dependent BG070935 aryl hydrocarbon receptor nuclear translocator 0.57 2.19 4.31 1.50 regulation of transcription, DNA-dependent BG079634 necdin 1.16 4.70 3.38 0.95 regulation of cell cycle BG086925 neuroblastoma ras oncogene 0.67 2.26 2.51 1.35 regulation of transcription, DNA-dependent BG067757 ankyrin repeat domain 25 0.35 2.40 3.61 1.22 inhibition of caspase activation BG068473 baculoviral IAP repeat-containing 4 0.26 3.81 3.73 1.12 cell cycle BG073277 septin 6 0.47 2.00 2.93 1.06 regulation of cell cycle BG074422 integrin beta 1 (fibronectin receptor beta) 0.35 2.27 3.19 0.89 meiosis BG068865 SMC (structural maintenance of chromosomes 1)-like 1 (S. cerevisiae) 0.09 3.47 4.75 1.51 anti-apoptosis BG075165 insulin-like growth factor 1 0.48 4.20 4.99 1.12 negative regulation of transcription from Pol II promoter BG084566 retinoblastoma binding protein 7 0.69 2.36 2.72 1.10 death BG069673 mortality factor 4 like 2 0.35 2.42 2.84 1.03 synapsis BI076713 mutS homolog 4 (E. coli) 24.76 6.07 2.14 1.00 nuclear division BG084917 anaphase promoting complex subunit 4 0.78 2.27 2.37 0.89 apoptosis BG086002 cytotoxic granule-associated RNA binding protein 1 2.09 5.21 2.64 1.02 regulation of transcription, DNA-dependent BG081767 RIKEN cDNA 5730521P14 gene 0.66 2.26 3.01 1.31 S phase of mitotic cell cycle BG073014 single-stranded DNA binding protein 1 0.35 2.79 2.94 1.00 regulation of transcription, DNA-dependent AA408197 signal transducer and activator of transcription 1 0.61 2.04 2.77 1.18 regulation of cell cycle BG069956 v-crk sarcoma virus CT10 oncogene homolog (avian) 0.55 2.22 2.40 0.97 cell cycle BG080390 regulator of G-protein signaling 2 0.59 3.22 4.88 1.13 apoptosis BG072439 serum/glucocorticoid regulated kinase 0.22 2.10 2.89 1.11 regulation of transcription, DNA-dependent BG087946 upstream binding transcription factor, RNA polymerase I 0.48 2.72 3.75 1.30 apoptosis BG080700 tumor necrosis factor receptor superfamily, member 12a 0.09 3.10 5.78 1.33 regulation of transcription, DNA-dependent BG075907 RE1-silencing transcription factor 0.61 2.53 2.73 1.30 regulation of cell cycle BG077186 heat shock protein 8 0.30 2.19 2.17 0.96 regulation of transcription, DNA-dependent BG078748 catenin beta 0.34 2.50 2.43 0.89 regulation of transcription, DNA-dependent BG064661 brain abundant, membrane attached signal protein 1 0.47 3.31 3.62 0.91 S phase of mitotic cell cycle BG087100 origin recognition complex, subunit 6-like (S. cerevisiae) 0.55 2.47 3.43 0.83 anti-apoptosis BG086134 nuclear interacting partner of anaplastic lymphoma kinase (Alk) 1.90 3.70 2.00 0.95 regulation of transcription from Pol I promoter BG074244 nucleosome binding protein 1 0.35 2.66 4.37 1.32 cell cycle AU042876 cyclin-dependent kinase 5 1.27 2.42 4.30 1.04 regulation of transcription, DNA-dependent BG084378 forkhead box O1 0.72 2.17 2.29 1.19 cell cycle BG074903 cullin 7 0.55 2.01 2.29 1.05 regulation of transcription, DNA-dependent BG068715 BRAF35/HDAC2 complex 0.58 2.49 2.82 2.24 regulation of translation BG076824 aconitase 1 0.60 2.08 3.02 1.13 regulation of transcription, DNA-dependent BG066209 myeloid/lymphoid or mixed-lineage leukemia 3 0.65 2.52 3.70 1.29 S phase of mitotic cell cycle BG082929 SET translocation 0.30 2.34 3.72 1.08 regulation of transcription, DNA-dependent BG078700 high mobility group box 3 0.66 2.10 2.39 1.00 regulation of cell cycle BG064886 heat shock protein 8 0.30 2.01 3.00 0.98 regulation of transcription, DNA-dependent BG074409 transcription factor E2a 0.41 2.68 3.91 1.04 induction of programmed cell death BG083524 caspase 3, apoptosis related cysteine protease 0.18 3.32 2.98 1.13 caspase activation via cytochrome c BG078810 cytochrome c, somatic 0.75 2.14 2.91 1.03 regulation of transcription, DNA-dependent BG070895 RB-associated KRAB repressor 0.49 2.09 2.01 1.01 nuclear division BG064663 anaphase promoting complex subunit 7 0.49 2.18 3.11 0.93 nuclear division BG069986 cyclin A2 0.35 2.34 2.70 1.03 death AU043450 mutS homolog 2 (E. coli) 0.43 3.39 4.06 0.85 transcription BG082553 polymerase (RNA) II (DNA directed) polypeptide J 0.57 2.10 2.65 0.91 induction of programmed cell death BG065768 forkhead box O3 0.63 2.65 5.62 1.06 apoptosis BG064035 phosphoprotein enriched in astrocytes 15 0.30 2.04 3.49 1.26 sex differentiation BG069739 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 0.91 2.17 2.62 1.10 regulation of cell cycle BG085624 ribosomal protein S4, X-linked 0.14 2.28 2.02 0.89 regulation of cell cycle BG087999 cyclin-dependent kinase 4 0.20 2.27 2.81 1.27 negative regulation of cell cycle BG070122 adenomatosis polyposis coli 0.63 2.28 4.81 1.76 sex determination BG084823 mago-nashi homolog, proliferation-associated (Drosophila) 0.52 2.05 2.01 DNA damage response, signal transduction resulting in cell cycle arrest BG081247 protein tyrosine phosphatase, non-receptor type 11 0.38 2.34 2.56 1.08 induction of programmed cell death BG088461 nerve growth factor receptor (TNFRSF16) associated protein 1 0.21 2.64 2.37 1.45

Cluster 3 regulation of transcription, DNA-dependent BG068832 0 day neonate lung cDNA, RIKEN full-length enriched library 0.92 2.10 1.57 1.10 clone:E030006G18 product:unknown EST, full insert sequence regulation of transcription, DNA-dependent BG069294 transcription factor 19 0.20 2.10 1.30 0.94 regulation of transcription, DNA-dependent C80656 RNA-binding region (RNP1, RRM) containing 2 0.72 2.24 1.40 0.95 regulation of transcription, DNA-dependent BG084751 Wiskott-Aldrich syndrome-like (human) 0.55 2.61 1.95 1.10 regulation of transcription, DNA-dependent BG071201 CXXC finger 1 (PHD domain) 1.18 2.02 1.58 1.15 regulation of transcription, DNA-dependent BG072519 forkhead box N4 0.87 2.46 1.49 1.13 sex differentiation BG086084 wingless-related MMTV integration site 4 0.72 3.34 1.63 0.99 induction of programmed cell death BG073027 caspase 8 associated protein 2 0.50 2.76 1.85 1.10 programmed cell death BG087671 growth arrest specific 1 0.16 2.14 0.99 1.04 regulation of transcription, DNA-dependent BG086487 E2F transcription factor 6 1.00 2.39 1.29 1.01 synaptonemal complex formation BG076157 synaptonemal complex protein 1 13.81 2.11 1.14 0.70 regulation of transcription, DNA-dependent BG081569 transcription factor E3 0.71 2.19 1.98 regulation of transcription, DNA-dependent BG083092 RIKEN cDNA D330024H06 gene 1.98 2.36 0.83 1.17 translational initiation BG078108 basic leucine zipper and W2 domains 1 0.34 2.48 1.99 0.83 regulation of transcription, DNA-dependent BG073553 RAB1, member RAS oncogene family 0.60 2.61 1.06 0.78 re-entry into mitotic cell cycle BG083088 cyclin D1 0.16 3.46 0.85 1.29 regulation of cell cycle BG085673 anaphase promoting complex subunit 1 0.91 2.51 1.37 1.06 nucleotide-excision repair BG081218 DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae) 0.42 2.18 1.56 0.84 positive regulation of meiosis BG086966 deleted in azoospermia-like 3.71 2.06 1.76 1.14 regulation of transcription, DNA-dependent BG066534 DNA segment, Chr 11, ERATO Doi 530, expressed 0.91 2.18 1.39 1.16 S phase of mitotic cell cycle BG075372 replication protein A2 0.99 2.02 1.87 0.89 anti-apoptosis BG079327 baculoviral IAP repeat-containing 6 0.31 2.52 1.15 1.18 S phase of mitotic cell cycle BG088470 origin recognition complex, subunit 4-like (S. cerevisiae) 0.77 2.23 1.17 1.13 transcription from Pol I promoter BG088541 exosome component 8 0.97 2.06 1.53 0.86 cell cycle BG072545 CDC28 protein kinase 1 0.18 2.28 1.91 0.93 regulation of cell cycle AW547625 cyclin D2 0.26 2.87 1.21 1.31 synaptonemal complex formation BG068906 cytoplasmic polyadenylation element binding protein 1 1.74 2.22 1.78 0.91 regulation of cell cycle BG073613 insulin-like growth factor 2 0.76 2.72 1.58 0.94 transcription from Pol I promoter AW546565 exosome component 7 0.53 2.01 1.73 0.78 nuclear division BG084144 stromal antigen 1 1.18 2.01 1.21 1.26 regulation of transcription, DNA-dependent BG075357 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) 0.35 2.31 1.67 0.92 spermatogenesis BG073493 DNA methyltransferase 3A 0.87 2.45 1.38 0.86 DNA repair BG072904 RAD51 homolog (S. cerevisiae) 0.85 1.99 1.53 0.97

Cluster 4 spermatogenesis BG086600 carnitine deficiency-associated gene expressed in ventricle 1 1.67 0.55 0.46 0.82 transcription from Pol III promoter BG070400 zinc finger protein 143 1.62 0.63 0.37 0.76 apoptosis BG082718 BCL2-associated athanogene 4 2.14 0.57 0.43 0.92 nuclear division BG083982 centrin 3 2.16 0.51 0.33 0.73 regulation of transcription, DNA-dependent BG064201 Ewing sarcoma homolog 1.89 0.56 0.43 0.80 M phase BG081419 centromere protein E 1.02 0.66 0.45 1.00 S phase of mitotic cell cycle BG064736 ribonucleotide reductase M1 0.81 0.77 0.44 0.87 mitotic cell cycle BG081629 SMC4 structural maintenance of chromosomes 4-like 1 (yeast) 1.98 0.72 0.45 0.62 negative regulation of transcription from Pol II promoter BG066448 serine/threonine kinase receptor associated protein 2.13 0.52 0.39 0.84 regulation of transcription, DNA-dependent BG084172 X-box binding protein 1 0.48 0.53 0.41 0.76 regulation of transcription, DNA-dependent BG077060 coactivator-associated arginine methyltransferase 1 0.99 0.68 0.45 0.83 DNA repair BG068820 breast cancer 2 4.08 0.69 0.44 0.60 cell cycle BG075848 septin 2 0.87 0.80 0.43 0.97 regulation of transcription, DNA-dependent BG074931 enhancer of zeste homolog 2 (Drosophila) 1.77 0.52 0.45 0.76 regulation of transcription, DNA-dependent BG069319 bromodomain adjacent to zinc finger domain, 2A 4.18 0.51 0.34 0.75 regulation of cell cycle BG082469 apoptosis antagonizing transcription factor 1.96 0.59 0.49 0.92 S phase of mitotic cell cycle BG067003 zuotin related factor 2 2.43 0.68 0.35 0.85 translational initiation BG086416 eukaryotic translation initiation factor 4 gamma, 3 1.30 0.51 0.40 0.81 negative regulation of transcription BG079550 protease (prosome, macropain) 26S subunit, ATPase 5 2.56 0.51 0.41 0.74 transcription initiation from Pol II promoter BG079546 nuclear receptor coactivator 6 2.64 0.54 0.44 0.80 regulation of transcription, DNA-dependent BG071880 l(3)mbt-like 2 (Drosophila) 1.85 0.80 0.50 0.75 regulation of transcription, DNA-dependent BG080166 RAB, member of RAS oncogene family-like 3 2.06 0.87 0.38 0.84 transcription initiation from Pol II promoter BG087634 general transcription factor II E, polypeptide 2 (beta subunit) 7.42 0.52 0.38 0.80 translational initiation BG087307 eukaryotic translation initiation factor 4B 0.48 0.60 0.48 1.19 mitotic cell cycle BG071804 budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 1.50 0.54 0.28 0.63 negative regulation of transcription BG072016 DNA methyltransferase 1-associated protein 1 3.24 0.69 0.48 0.77 regulation of cell cycle BG066221 expressed sequence AA545217 1.91 0.51 0.42 0.94 transcription initiation BG065064 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor 0.50 0.23 0.66 apoptosis BG064850 diablo homolog (Drosophila) 7.24 0.54 0.36 0.47 regulation of transcription, DNA-dependent AW553304 BTB and CNC homology 2 1.13 0.57 0.29 0.84 S phase of mitotic cell cycle BG064763 topoisomerase (DNA) III beta 1.71 0.58 0.41 0.78 transcription initiation BG088295 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor 2.49 0.62 0.48 0.99 negative regulation of transcription from Pol II promoter BG064616 RING1 and YY1 binding protein 0.96 0.72 0.44 0.73 transcription BG066998 RNA polymerase 1-1 1.65 0.69 0.32 0.70 regulation of transcription, DNA-dependent BG065028 ubiquitin-like, containing PHD and RING finger domains, 1 1.20 0.57 0.42 0.85 DNA damage response, signal transduction resulting in cell cycle arrest BG069077 Hus1 homolog (S. pombe) 1.25 0.71 0.39 0.84 regulation of transcription, DNA-dependent BG068329 myeloblastosis oncogene-like 1 1.91 0.59 0.24 0.90 S phase of mitotic cell cycle BG078138 ribonucleotide reductase M2 0.60 0.82 0.49 0.86

Cluster 5 cell cycle BG076617 calmodulin 1 3.96 0.48 0.41 0.89 regulation of transcription, DNA-dependent BG063425 SERTA domain containing 2 1.94 0.18 0.23 1.02 spermatogenesis BG083548 DNA segment, Chr 1, Pasteur Institute 1,probable ATP-dependent RNA helicase 45.73 0.30 0.20 0.45 spermatogenesis BG087221 tousled-like kinase 2 (Arabidopsis) 3.43 0.42 0.37 0.88 meiosis BG069318 testis specific gene A2 34.21 0.26 0.11 0.26 transcription initiation BG067596 suppressor of Ty 3 homolog (S. cerevisiae) 1.86 0.49 0.43 0.84 regulation of transcription, DNA-dependent BG072550 calcium regulated heat stable protein 1 2.98 0.27 0.31 0.92 cell cycle BG065132 protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform 5.10 0.19 0.19 0.98 regulation of transcription, DNA-dependent BG063049 myeloid/lymphoid or mixed lineage-leukemia translocation to 1 homolog (Drosophila) 1.70 0.40 0.35 0.84 meiosis BG085432 chondroitin sulfate proteoglycan 6 10.16 0.22 0.18 0.67 regulation of transcription, DNA-dependent BG086766 high mobility group 20A 5.00 0.42 0.36 0.63 M phase AU044112 cell division cycle associated 1 2.41 0.49 0.35 0.64 regulation of transcription, DNA-dependent BG065409 phospholipase A2, group VI 3.43 0.31 0.41 0.87 regulation of transcription, DNA-dependent AW556196 activating signal cointegrator 1 complex subunit 1 2.89 0.24 0.23 1.00 regulation of transcription, DNA-dependent BG069630 tripartite motif protein 28 2.40 0.47 0.44 0.74 apoptosis BG067012 myeloid cell leukemia sequence 1 2.45 0.35 0.22 0.92 cell cycle BG078368 polo-like kinase 1 (Drosophila) 2.34 0.19 0.19 1.10 meiosis BG081004 replication protein A1 1.62 0.32 0.42 1.32 regulation of transcription, DNA-dependent BG076618 myotrophin 2.30 0.45 0.48 0.96 regulation of cell cycle BG067022 v-raf-1 leukemia viral oncogene 1 4.02 0.42 0.26 0.78 regulation of transcription from Pol II promoter BG082453 T-box 19 3.15 0.44 0.37 1.09 regulation of transcription, DNA-dependent BG078271 cartilage homeo protein 1 3.46 0.40 0.33 0.73 spermatogenesis BG071699 RAD23b homolog (S. cerevisiae) 3.34 0.34 0.37 0.88 regulation of transcription, DNA-dependent BG072751 histone deacetylase 11 2.49 0.17 0.18 0.97 germ-cell development BG088519 FK506 binding protein 12-rapamycin associated protein 1 4.76 0.47 0.42 0.83 negative regulation of transcription from Pol II promoter BG065040 nuclear receptor subfamily 6, group A, member 1 3.53 0.36 0.30 0.92 nuclear division BG071915 cyclin B2 4.09 0.27 0.12 0.46 regulation of cell cycle BG081785 transformed mouse 3T3 cell double minute 2 2.98 0.35 0.33 0.88 spermatogenesis BG085669 male enhanced antigen 1 12.12 0.08 0.08 0.64 regulation of transcription, DNA-dependent BG063789 bisphosphate 3'-nucleotidase 1 1.72 0.34 0.32 0.52 anti-apoptosis BG078469 polymerase (DNA directed), beta 6.84 0.17 0.12 0.70 regulation of transcription, DNA-dependent BG082226 feminization 1 homolog b (C. elegans) 3.10 0.18 0.16 0.88 regulation of transcription from Pol II promoter BG070944 WD repeat domain 9 2.92 0.31 0.29 0.76 regulation of transcription, DNA-dependent BG086963 zinc finger protein 96 5.37 0.22 0.18 0.96 nuclear division BG071981 fizzy/cell division cycle 20 related 1 (Drosophila) 1.92 0.36 0.25 0.78 apoptosis BG088471 B-cell receptor-associated protein 29 2.96 0.32 0.34 0.63 nuclear division BG084246 sperm associated antigen 5 3.46 0.29 0.08 0.82 induction of programmed cell death BG083236 phosphatase and tensin homolog 1.25 0.43 0.47 1.29 transcription initiation from Pol II promoter BG066097 RIKEN cDNA 2810405L04 gene 3.88 0.39 0.33 0.79 regulation of cell cycle BG088124 cyclin D3 1.95 0.20 0.49 1.38 regulation of transcription, DNA-dependent BG072398 fos-like antigen 2 1.40 0.43 0.32 1.07 translational elongation BG072779 eukaryotic translation elongation factor 1 gamma 0.67 0.33 0.26 0.86 cell cycle BG077290 serine/threonine kinase 6 2.76 0.23 0.22 0.80 regulation of cell cycle BG064232 cyclin I 1.68 0.49 0.23 0.86 M phase BG082611 pericentrin 2 3.34 0.39 0.48 1.05 nuclear division BG077338 chromosome condensation 1 1.90 0.43 0.36 0.93 regulation of transcription, DNA-dependent BG077386 zinc finger protein 162 1.31 0.47 0.50 0.97 female gamete generation BG076954 dynein, cytoplasmic, light chain 1 3.35 0.46 0.46 0.67 regulation of transcription, DNA-dependent BG063128 inhibitor of growth family, member 1 2.50 0.40 0.48 1.12 regulation of transcription, DNA-dependent BG083245 nuclease sensitive element binding protein 1 1.96 0.29 0.22 0.49 regulation of transcription, DNA-dependent BG075801 PHD finger protein 1 2.31 0.33 0.30 0.70 apoptosis BG080554 ubiquitin conjugating enzyme 7 interacting protein 1 4.48 0.43 0.22 1.27 S phase of mitotic cell cycle BG065181 RNA binding motif, single stranded interacting protein 1 1.10 0.29 0.46 0.93 meiotic prophase I BG071825 RIKEN cDNA 2810429C13 gene 3.09 0.35 0.33 0.89 regulation of cell cycle BG071965 cyclin B1 1.41 0.45 0.36 0.93 apoptosis BG078223 serine/threonine kinase 3 (Ste20, yeast homolog) 3.55 0.30 0.28 0.79 regulation of transcription, DNA-dependent BG071057 bromodomain adjacent to zinc finger domain 1A 5.08 0.32 0.31 0.68 regulation of transcription, DNA-dependent BG067790 RAR-related orphan receptor alpha 2.96 0.31 0.35 1.12 regulation of transcription, DNA-dependent BG072422 SAM pointed domain containing ets transcription factor 3.92 0.30 0.41 1.09 apoptosis BG070891 death effector domain-containing 4.24 0.31 0.35 0.79 translational initiation AW537726 eukaryotic translation initiation factor 5 4.28 0.35 0.32 0.82 induction of programmed cell death BG070314 SH3-domain GRB2-like B1 (endophilin) 1.96 0.42 0.29 0.61 cell cycle arrest BG085641 cyclin-dependent kinase inhibitor 3 6.59 0.12 0.12 0.85 regulation of transcription, DNA-dependent BG067927 metal response element binding transcription factor 1 8.28 0.15 0.14 1.28 nuclear division BG064087 sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) 5.16 0.25 0.24 0.70 regulation of transcription, DNA-dependent BG080442 globin inducing factor, fetal 2.10 0.44 0.31 0.90 S phase of mitotic cell cycle BG073925 ubiquitin specific protease 8 5.53 0.33 0.29 0.72 regulation of transcription, DNA-dependent BG063631 GATA binding protein 2 2.87 0.27 0.11 0.79 regulation of cell cycle BG082890 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 3.07 0.25 0.41 0.79 S phase of mitotic cell cycle BG081018 origin recognition complex, subunit 3-like (S. cerevisiae) 5.56 0.21 0.20 0.79 negative regulation of transcription from Pol II promoter BG088432 Dr1 associated protein 1 (negative cofactor 2 alpha) 3.03 0.40 0.42 0.63 DNA repair BG070452 chromatin assembly factor 1, subunit A (p150) 3.96 0.16 0.21 0.65 regulation of transcription, DNA-dependent BG078457 ash2 (absent, small, or homeotic)-like (Drosophila) 3.08 0.46 0.39 0.74 transcription from Pol I promoter BG076800 exosome component 5 4.83 0.26 0.45 0.76 regulation of transcription, DNA-dependent BG072673 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.35 0.41 0.48 0.81 spermatogenesis BG075223 OVO homolog-like 1 (Drosophila) 1.95 0.24 0.22 0.79 nucleotide-excision repair BG064322 excision repair cross-complementing rodent repair deficiency, complementation group 1 1.47 0.39 0.47 0.82 apoptosis BG074856 Fas-activated serine/threonine kinase 2.26 0.45 0.49 0.73 male meiosis BG075601 stromal antigen 3 29.57 0.42 0.39 0.79 nuclear division BG079263 cell division cycle 25 homolog C (S. cerevisiae) 1.12 0.27 0.28 1.09 translational initiation BG069032 RIKEN cDNA 1500010M16 gene 3.29 0.49 0.32 0.72 regulation of transcription, DNA-dependent BG066638 POU domain, class 6, transcription factor 1 2.84 0.41 0.32 0.62 meiotic anaphase I BG071861 10 days neonate skin cDNA, RIKEN full-length enriched library 2.23 0.45 0.26 0.98 clone:4732457F20 product:unknown EST, full insert sequence regulation of transcription, DNA-dependent BG084388 transcription elongation factor B (SIII), polypeptide 1 2.70 0.38 0.37 0.63 translational elongation BG086674 eukaryotic translation elongation factor 2 0.81 0.41 0.46 0.92 nuclear division BG072979 nucleolar and spindle associated protein 1 1.05 0.50 0.45 1.03 apoptotic mitochondrial changes BG078504 death associated protein 3 3.46 0.45 0.36 0.85 spermatogenesis BG072247 zinc finger protein 35 5.75 0.22 0.16 0.74 S phase of mitotic cell cycle BG086905 replication factor C (activator 1) 2 2.42 0.47 0.36 0.80 apoptosis BG080578 modulator of apoptosis 1 3.38 0.37 0.46 1.59 regulation of transcription, DNA-dependent BG072971 zinc finger protein 110 4.22 0.33 0.23 0.83 transcription initiation from Pol II promoter BG088284 general transcription factor II A, 2 4.37 0.29 0.33 0.70 nuclear division BG088511 RAN, member RAS oncogene family 1.94 0.33 0.22 0.73 regulation of cell cycle BG079239 DEAH (Asp-Glu-Ala-His) box polypeptide 16 2.37 0.43 0.42 0.81 regulation of transcription from Pol II promoter BG066480 Msx2 interacting nuclear target protein 1.75 0.34 0.30 1.10 regulation of transcription, DNA-dependent BG081415 transcription factor A, mitochondrial 4.71 0.10 0.10 1.02 regulation of transcription, DNA-dependent BG078193 basic transcription factor 3 1.33 0.40 0.44 0.81 regulation of transcription, DNA-dependent BG084550 Kruppel-like factor 5 1.31 0.26 0.32 1.10 translational elongation BG064633 signal recognition particle 9 2.00 0.48 0.42 0.81 regulation of transcription, DNA-dependent BG067274 one cut domain, family member 1 3.61 0.15 0.20 1.01 negative regulation of transcription from Pol II promoter BG088830 down-regulator of transcription 1 2.67 0.43 0.40 0.66 S phase of mitotic cell cycle BG064892 RIKEN cDNA 2400006P09 gene 6.41 0.09 0.13 0.91 regulation of transcription, DNA-dependent BG071982 zinc finger protein 57 2.10 0.12 0.32 1.02 nuclear division BG066279 cell division cycle 25 homolog A (S. cerevisiae) 3.53 0.49 0.36 1.02 negative regulation of cell cycle BG077363 breast cancer metastasis-suppressor 1 4.40 0.23 0.21 0.96 translational elongation AW537663 G1 to phase transition 1 1.23 0.49 0.27 0.86 meiosis BG065826 NIMA (never in mitosis gene a)-related expressed kinase 2 5.39 0.38 0.22 0.73 regulation of transcription, DNA-dependent BG069438 zinc finger protein 535 1.84 0.49 0.44 0.96 regulation of transcription, DNA-dependent BG088509 RIKEN cDNA 5730410I19 gene 4.89 0.34 0.25 1.04 DNA recombination BG087837 RuvB-like protein 2 2.55 0.27 0.23 0.68 cell cycle BG067380 aurora kinase C 7.25 0.17 0.10 1.13 negative regulation of transcription from Pol II promoter BG076602 cut-like 1 (Drosophila) 1.61 0.27 0.27 0.92 regulation of transcription, DNA-dependent BG076670 RIKEN cDNA 4921515A04 gene 2.80 0.34 0.27 0.90 S phase of mitotic cell cycle BG082462 polymerase (DNA-directed), delta 3, accessory subunit 6.02 0.30 0.16 0.91 gametogenesis BG068797 RIKEN cDNA 7420700M05 gene 5.92 0.17 0.17 1.21 regulation of transcription, DNA-dependent BG065131 suppressor of K+ transport defect 3 4.88 0.10 0.10 0.97 regulation of translation BG085457 MAP kinase-interacting serine/threonine kinase 2 2.98 0.35 0.42 0.81 regulation of transcription, DNA-dependent BG069413 Kruppel-like factor 4 (gut) 5.90 0.12 0.15 1.07 regulation of transcription, DNA-dependent BG069829 special AT-rich sequence binding protein 1 1.53 0.33 0.42 0.99 induction of programmed cell death BG073824 catenin, beta like 1 3.87 0.33 0.40 0.86 G2/M transition of mitotic cell cycle BG088678 protein phosphatase 1D magnesium-dependent, delta isoform 10.75 0.14 0.14 0.80 DNA repair BG067355 polymerase (DNA directed), lambda 4.31 0.27 0.36 1.02 regulation of transcription, DNA-dependent BG072085 CBFA2T1 identified gene homolog (human) 2.52 0.39 0.40 0.96 positive regulation of transcription from Pol II promoter AA409376 nuclear transcription factor-Y alpha 2.33 0.39 0.38 0.95 regulation of cell cycle BG069401 casein kinase II, alpha 2, polypeptide 2.10 0.46 0.50 1.00 spermatogenesis BG068033 platelet-activating factor acetylhydrolase, isoform 1b, beta1 subunit 6.37 0.31 0.26 1.09 binding of sperm to zona pellucida BG087046 arylsulfatase A 4.95 0.26 0.40 0.91 transcription, DNA-dependent BG065828 Msx-interacting-zinc finger 10.53 0.23 0.14 0.72 spermatogenesis BG067010 HIV-1 Rev binding protein 3.65 0.28 0.16 0.80 meiotic anaphase I BG083139 pituitary tumor-transforming 1 1.52 0.35 0.38 0.73 apoptosis BG069990 Bcl2-associated athanogene 1 7.01 0.21 0.28 0.90 regulation of transcription, DNA-dependent BG067894 HLA-B associated transcript 4 2.68 0.31 0.36 0.95 single strand break repair BG064594 ligase IV, DNA, ATP-dependent 2.44 0.28 0.35 0.77 anti-apoptosis BG077309 baculoviral IAP repeat-containing 5 1.14 0.41 0.22 0.74 acrosome reaction BG076517 tripartite motif-containing 36 1.80 0.22 0.22 0.77 regulation of transcription, DNA-dependent BG078784 homeo box B1 1.93 0.26 0.41 0.95 nuclear division BG075866 MAD2 mitotic arrest deficient-like 2 (yeast) 7.71 0.16 0.11 0.66 AW550650 t-complex testis expressed 1 8.56 0.29 0.14 0.37 AU042878 Hop2 8.64 0.35 0.17 0.42 BG068392 bromodomain, testis-specific 48.00 0.26 0.16 0.61

Cluster 6 apoptosis BG070296 AXIN1 up-regulated 1 1.41 0.48 0.76 1.00 regulation of transcription, DNA-dependent BG075925 RIKEN cDNA 4631416I11 gene 1.84 0.47 1.31 0.75 translational initiation BG086987 suppressor of initiator codon mutations, related sequence 1 (S. cerevisiae) 1.42 0.39 0.56 0.84 regulation of transcription, DNA-dependent BG070860 glial cells missing homolog 2 (Drosophila) 2.11 0.42 0.79 1.35 transcription initiation from Pol II promoter BG086631 general transcription factor IIF, polypeptide 2 2.90 0.48 0.53 0.87 nuclear division BG069578 cyclin G1 1.41 0.41 0.55 1.04 RNA elongation from Pol II promoter BG085211 elongation factor RNA polymerase II 2 1.97 0.35 0.77 1.07 regulation of transcription, DNA-dependent BG086798 retinoblastoma-like 2 2.00 0.49 0.78 0.95 cell cycle BG070859 RIKEN cDNA 4921518A06 gene 2.07 0.42 0.61 0.87 transcription BG069995 general transcription factor IIIC, polypeptide 4 1.89 0.39 0.58 1.25 transcription from Pol I promoter BG072576 exosome component 3 1.01 0.44 0.75 0.90 regulation of transcription, DNA-dependent BG073726 hepatoma-derived growth factor, related protein 2 2.67 0.50 0.55 0.96 apoptosis AU041226 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor 2.53 0.41 0.64 0.78 non-recombinational repair BG075806 thyroid autoantigen 1.42 0.49 0.66 0.86 regulation of transcription from Pol II promoter BG074964 steroid receptor RNA activator 1 1.50 0.48 0.86 0.82 transcription from Pol II promoter BG083463 polymerase (RNA) II (DNA directed) polypeptide I 3.41 0.49 0.56 0.77 positive regulation of transcription BG079163 ras homolog gene family, member G 2.08 0.47 1.04 1.31 regulation of transcription, DNA-dependent BG088746 tripartite motif protein 27 1.46 0.38 0.51 0.93 anti-apoptosis BG075765 defender against cell death 1 2.64 0.43 0.65 0.81 regulation of transcription, DNA-dependent BG075820 dachshund 1 (Drosophila) 2.33 0.48 0.76 1.03 G1/S transition of mitotic cell cycle AW556297 protein phosphatase 3, catalytic subunit, alpha isoform 1.45 0.50 0.79 0.71 spermatogenesis BG073114 bromodomain containing 2 2.25 0.44 0.51 0.93 regulation of transcription, DNA-dependent BG088216 HLA-B associated transcript 8 2.06 0.43 0.55 0.91 translational termination BG070441 eukaryotic translation termination factor 1 3.24 0.31 0.56 1.11 regulation of transcription, DNA-dependent BG071098 ring finger protein 12 2.27 0.42 0.59 2.36 regulation of cell cycle BG077659 ELK3, member of ETS oncogene family 1.08 0.41 1.68 1.11 spermatogenesis C88099 platelet-activating factor acetylhydrolase, isoform 1b, alpha1 subunit 2.66 0.44 0.67 1.18 regulation of transcription, DNA-dependent BG069338 methyl-CpG binding domain protein 3 1.90 0.48 0.53 0.69 regulation of transcription, DNA-dependent BG069368 regulatory factor X, 1 (influences HLA class II expression) 2.02 0.48 0.50 1.16 anti-apoptosis BG079597 Bcl2-associated athanogene 3 1.25 0.34 0.58 0.97