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Table 4 Selected Early and Late Genes in Adult Spo11-/- Testes and Juvenile Wild-Type Testes

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Table 4 Selected Early and Late Genes in Adult Spo11-/- Testes and Juvenile Wild-Type Testes Table 4 Selected early and late genes in adult Spo11-/- testes and juvenile wild-type testes Average signal ratio Adult wild- 15dpp wild- Adult 15dpp type vs type vs Spo11 -/- vs Spo11 -/- vs reference adult wild- adult wild- 15dpp wild- GO/ Biological process ID Name RNA type type type Cluster 1 regulation of transcription, DNA-dependent BG086576 ankyrin repeat and FYVE domain containing 1 0.45 1.94 2.76 1.29 induction of programmed cell death BG074245 pleiomorphic adenoma gene-like 2 0.79 1.95 2.72 1.10 induction of programmed cell death BG065030 glutathione peroxidase 1 0.37 1.25 5.23 0.85 regulation of transcription, DNA-dependent BG072554 ankyrin repeat domain 10 0.21 1.84 2.05 0.98 regulation of transcription, DNA-dependent BG075473 nuclear receptor subfamily 3, group C, member 1 0.76 1.16 2.87 1.15 regulation of cell cycle BG077774 v-abl Abelson murine leukemia oncogene 1 0.27 1.70 2.23 1.04 germ-cell development BG063365 chemokine (C-X-C motif) receptor 4 0.48 1.77 2.41 0.98 regulation of transcription, DNA-dependent BG087880 jumonji, AT rich interactive domain 1C (Rbp2 like) 0.37 1.90 3.07 1.27 fertilization (sensu Animalia) BG073671 milk fat globule-EGF factor 8 protein 0.52 1.42 2.90 0.98 regulation of transcription, DNA-dependent BG084537 replication factor C 1 0.64 1.86 2.55 0.80 regulation of cell cycle BG088254 BRCA2 and CDKN1A interacting protein 1.02 1.30 2.02 0.92 regulation of transcription, DNA-dependent BG085396 transforming growth factor beta 1 induced transcript 4 1.47 0.88 2.25 0.88 positive regulation of transcription BG088871 GATA binding protein 4 (Gata4), mRNA 1.97 1.36 2.34 0.94 DNA damage response, signal transduction resulting in cell cycle arrest BG070939 checkpoint kinase 1 homolog (S. pombe) 0.73 1.84 2.78 1.02 apoptosis BG064583 testis enhanced gene transcript 0.48 1.36 2.21 1.03 apoptosis BG064074 B-cell receptor-associated protein 31 0.44 1.55 2.35 1.46 apoptosis BG085048 caspase recruitment domain family, member 10 0.76 1.17 2.40 1.10 translational initiation BG070960 eukaryotic translation initiation factor 4, gamma 2 0.54 1.38 2.06 0.99 DNA repair BG071999 UV radiation resistance associated gene 0.68 1.62 2.29 0.95 regulation of transcription, DNA-dependent BG073938 single-stranded DNA binding protein 3 0.64 1.56 2.12 1.09 cell death BG072209 clusterin 8.21 1.60 4.50 1.15 anti-apoptosis BG084405 baculoviral IAP repeat-containing 3 0.91 1.11 2.05 1.06 regulation of transcription, DNA-dependent BG086687 transcriptional regulator, SIN3B (yeast) 4.22 1.41 3.08 0.93 regulation of transcription, DNA-dependent BG067190 ankyrin repeat domain 6 0.86 1.93 2.79 1.16 DNA repair BG075420 casein kinase 1, delta 0.34 1.37 2.08 0.82 regulation of transcription, DNA-dependent BG076902 purine rich element binding protein A 0.59 1.80 2.21 0.93 apoptosis BG088241 lymphocyte specific 1 0.34 1.86 2.71 1.07 regulation of transcription, DNA-dependent BG066379 jumonji domain containing 2A 0.21 1.96 4.82 1.25 regulation of transcription, DNA-dependent BG067918 B-cell translocation gene 2, anti-proliferative 0.33 1.35 2.26 1.31 apoptosis BG077957 programmed cell death 6 0.56 1.28 2.01 1.11 regulation of transcription from Pol II promoter BG087452 Wilms tumor homolog 0.32 1.96 3.40 1.20 germ-cell development BG087137 kit oncogene 2.69 1.15 3.90 1.19 regulation of transcription from Pol II promoter BG084377 signal transducer and activator of transcription 3 0.51 1.81 2.88 1.05 DNA repair BG067126 single-strand selective monofunctional uracil DNA glycosylase 0.88 1.40 2.22 2.19 positive regulation of transcription from Pol II promoter BG077765 SRY-box containing gene 8 0.51 1.41 2.84 1.04 spermatogenesis BG064308 acyl-Coenzyme A oxidase 1, palmitoyl 1.65 0.25 5.00 1.01 regulation of transcription, DNA-dependent BG074917 general transcription factor II I 0.72 1.43 2.79 1.15 regulation of transcription, DNA-dependent BG064455 longevity assurance homolog 6 (S. cerevisiae) 0.84 1.58 2.51 1.32 transcription BG075851 polymerase (RNA) II (DNA directed) polypeptide B 0.51 1.16 2.45 1.05 regulation of transcription, DNA-dependent BG085373 GLI-Kruppel family member GLI2 0.51 1.54 2.15 1.19 nuclear division BG071683 centromere autoantigen H 0.59 1.44 2.34 0.99 regulation of transcription, DNA-dependent BG066892 upstream regulatory element binding protein 1e 0.27 2.00 4.33 1.82 translational elongation BG083078 LanC (bacterial lantibiotic synthetase component C)-like 2 0.85 1.43 2.05 0.87 male sex determination BG069156 insulin-like growth factor I receptor 0.41 1.92 2.04 1.03 apoptosis BG081632 Janus kinase 2 0.69 1.38 2.03 0.89 regulation of transcription, DNA-dependent BG072106 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.79 1.60 2.13 0.90 disassembly of cell structures BG074045 superoxide dismutase 1, soluble 1.15 0.85 2.23 0.96 induction of programmed cell death BG073154 BCL2/adenovirus E1B 19kD interacting protein like 0.86 1.50 2.86 1.08 apoptosis BG086954 amyloid beta (A4) precursor protein 0.59 1.75 2.59 1.12 apoptosis BG085493 ubiquitin-activating enzyme E1C 0.34 1.76 4.35 1.12 regulation of transcription, DNA-dependent BG069856 cyclin C 0.57 1.31 2.19 0.98 regulation of transcription, DNA-dependent BG079354 nuclear receptor co-repressor 2 0.82 1.96 2.52 1.08 anti-apoptosis BG086150 craniofacial development protein 1 0.23 1.46 2.09 0.91 regulation of transcription BG066422 prostaglandin E synthase 2 0.81 1.26 2.46 1.04 nucleotide-excision repair BG073656 serine/threonine kinase 2 0.14 1.96 2.33 1.02 apoptosis BG067419 growth arrest and DNA-damage-inducible 45 gamma 0.53 1.22 2.07 1.11 induction of programmed cell death BG076240 caspase 6 1.02 1.47 2.22 1.11 regulation of transcription, DNA-dependent AW552582 deformed epidermal autoregulatory factor 1 (Drosophila) 0.70 1.65 2.10 1.15 regulation of transcription, DNA-dependent BG077537 RIKEN cDNA 0610009M14 gene 0.65 1.22 2.19 1.08 nuclear division BG086107 pescadillo homolog 1, containing BRCT domain (zebrafish) 0.94 1.98 2.86 0.88 regulation of transcription, DNA-dependent BG084078 jumonji, AT rich interactive domain 1A (Rbp2 like) 1.06 1.85 3.61 1.17 regulation of transcription, DNA-dependent BG075386 bobby sox homolog (Drosophila) 0.89 1.42 2.02 1.01 positive regulation of transcription from Pol II promoter BG073001 cellular nucleic acid binding protein 0.72 1.69 2.08 0.87 fertilization (sensu Animalia) BG075310 transketolase 0.16 1.57 3.16 0.90 binding of sperm to zona pellucida BG084869 RIKEN cDNA A430096B05 gene 0.64 1.74 3.29 1.31 regulation of transcription, DNA-dependent BG079235 cellular repressor of E1A-stimulated genes 0.72 1.40 2.84 0.93 regulation of transcription, DNA-dependent BG064318 retinoic acid induced 1 1.19 0.65 2.77 1.01 cytolysis BG077623 hypoxanthine guanine phosphoribosyl transferase 0.90 1.77 2.01 1.21 regulation of transcription BG064108 PDZ and LIM domain 1 (elfin) 0.30 1.45 2.83 0.80 regulation of transcription, DNA-dependent BG087132 ubiquitin specific protease 49 1.39 1.22 2.04 0.94 DNA repair AU021534 flap structure specific endonuclease 1 0.66 1.76 2.59 0.92 positive regulation of transcription from Pol II promoter BG067330 nuclear receptor subfamily 5, group A, member 1 1.16 1.60 2.83 1.40 translational elongation BG074911 ribosomal protein, large, P1 0.32 1.34 2.12 1.13 induction of programmed cell death BG082842 Bcl-2-related ovarian killer protein 0.49 1.58 2.05 1.01 regulation of transcription, DNA-dependent BG064695 RIKEN cDNA A830092L04 gene 0.64 1.59 2.30 0.92 negative regulation of cell cycle BG086151 CDK2 (cyclin-dependent kinase 2)-associated protein 1 0.63 1.46 2.16 0.91 regulation of transcription, DNA-dependent BG086994 RAB7, member RAS oncogene family 0.41 1.63 2.77 1.12 single strand break repair BG069854 X-ray repair complementing defective repair in Chinese hamster cells 1 0.77 1.56 3.48 1.25 regulation of transcription, DNA-dependent BG069095 interferon consensus sequence binding protein 1 0.91 0.88 2.50 0.96 cell cycle arrest BG086554 microtubule-actin crosslinking factor 1 0.56 1.68 3.30 1.27 S phase of mitotic cell cycle BG084969 origin recognition complex, subunit 2-like (S. cerevisiae) 1.09 1.29 2.02 1.03 DNA repair BG072232 three prime repair exonuclease 1 1.17 1.38 2.09 0.84 S phase of mitotic cell cycle BG081111 topoisomerase (DNA) I 0.62 1.81 2.42 1.03 regulation of transcription, DNA-dependent BG086680 longevity assurance homolog 4 (S. cerevisiae) 0.23 1.86 3.17 0.94 regulation of transcription, DNA-dependent BG072359 fumarylacetoacetate hydrolase 0.61 1.76 2.37 1.04 cytolysis BG067456 lysozyme 1.28 1.77 4.27 0.62 transcription from Pol I promoter BG086106 fibrillarin 0.80 1.89 2.62 1.08 regulation of transcription, DNA-dependent BG076024 enhancer of zeste homolog 1 (Drosophila) 1.11 1.28 2.14 1.09 sex differentiation BG087691 anti-Mullerian hormone type 2 receptor 2.79 1.35 2.99 1.01 cell cycle BG074262 telomeric repeat binding factor 2 0.94 1.78 2.62 1.15 positive regulation of transcription from Pol II promoter BG086322 activating transcription factor 4 0.19 1.54 2.05 0.80 regulation of transcription, DNA-dependent BG088708 nuclear factor, erythroid derived 2,-like 1 0.86 1.38 2.11 1.00 regulation of transcription, DNA-dependent BG078428 placentae and embryos oncofetal gene 0.80 1.45 2.97 0.99 regulation of transcription, DNA-dependent BG068772 AE binding protein 2 0.34 1.74 3.94 1.12 regulation of transcription, DNA-dependent BG076162 zinc finger protein 612 1.44 1.57 2.24 1.20 induction of programmed cell death BG086310 caspase 9 0.42 1.40 2.50 0.98 regulation of
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