GP1BA Monoclonal Antibody, Clone B3222M

Home , Glycoprotein IX, GP1BA, Von Willebrand factor

GP1BA monoclonal antibody, clone Aliquot to avoid repeated freezing and thawing. B3222M Entrez GeneID: 2811

Catalog Number: MAB4144 Gene Symbol: GP1BA

Regulatory Status: For research use only (RUO) Gene Alias: BSS, CD42B, CD42b-alpha, GP1B, MGC34595 Product Description: Mouse monoclonal antibody raised against native GP1BA. Gene Summary: Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a Clone Name: B3222M heterodimer, an alpha chain and a beta chain, that are Immunogen: Native purified GP1BA from human linked by disulfide bonds. The Gp Ib functions as a washed platelets. receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of Host: Mouse the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Reactivity: Human Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular Applications: Flow Cyt, IP injury, and also initiates signaling events within the (See our web site product page for detailed applications platelet that lead to enhanced platelet activation, information) thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations Protocols: See our web site at have been described in this gene, some of which are the http://www.abnova.com/support/protocols.asp or product cause of Bernard-Soulier syndromes and platelet-type page for detailed protocols von Willebrand disease. [provided by RefSeq]

Specificity: The molecular weight of the recognized antigen is 160KDa. Reacts with glycoprotein Ib on megakaryocytes and platelets. Inhibits the ristocetin-dependent binding of Von Willebrand factor to platelets and ristocetin induced platelet agglutination. Inhibits platelet aggregation induced by Type I collagen and platelet activating factor (PAF). Immunoprecipitates the components of glycoprotein Ib complex.

Form: Lyophilized

Isotype: IgG1

Recommend Usage: Flow Cytometry (2ug/5x106 platelets/test) The optimal working dilution should be determined by the end user.

Storage Buffer: Lyophilized from PBS (1mg/mL BSA)

Storage Instruction: Store at 4°C on dry atmosphere. After reconstitution with deionized water, store at -20°C or lower.

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