January 31, 1995 Vol. XLVll No. 3 "Still U.S. Department of Health The Second and Human Services Best Thing About Payday" National Institutes of Health IH Recori Performing a 'Grace Note' OE's 'Saturday School' King Program Stresses 'Everyone Can Serve' Reaps Prompt Rewards By Carla Garnett By Ruth Levy Guyer ,C, and R may be, after N, I, and H, he high temperature on Friday, Jan. 13 was 68 degrees. In Masur Auditorium, che Pthe three letters most often juxtaposed NIH director recalled his I 960 procesc march, a surgeon miked jazz, children made in conversations on the NIH campus. So one T rainbows, and in between, all the traditional trappings-the posting of the colors, the would not normally label a discussion of reading of rhe litany, and entertainment by talented musicians-of an NIH Marcin Lurher PCR basics and the merits of che technology King, Jr. Commemoration were observed as well. "remarkable." But remarkable is an ape term Adopting the theme, "Everyone Can Serve; Help Somebody," rhe celebration sponsored by for a recent session in the Cloister, because NIH's Office of Equal Opportunity actually began weeks earlier when recepracles for donations che discussanrs were teenagers. of canned goods and ocher items to be disrribuced co area homeless shelters were placed in NIH The 25 students comfortably batting facilities. Program coordinaror O.H. Laster of OEO said an estimated "30 million Americans around words like polymerases, chermocy­ nightly go co bed hungry in che so-called cling, and restriction enzymes were summing land of plenty." Srariscics such as those, he (See SATURDAYS, Page 6} continued, prompted the humanitarian theme for this King commemoration. Two organizarions were designated to receive the donations-rhe Montgomery County department of social services in Maryland, and rhe House of lmagene in Washington, D.C. "Marrin Luther King, Jr. had a direct influence on my life and on my convictions," said NIH director Dr. Harold Varmus, who recalled his student days at Amherst College NIH director Dr. Harold Varmus (l) and NCI in chelate l 950's. During char time, he said, director Dr. Samuel Broder {c) join keynote there were about four African American ~ speaker Dr. LaSalle Leffel/ at NJH's Martin students in his class of 300 males. "Amherst Students who took part in the Saturday School Luther King, Jr. commemoration. (See KING COMMEMORATION, Page 8) familiarize themselves with lab work. Maria Freire To Direct Fluoridation Marks 50 Years of Cavity Prevention Technology Transfer By Patricia Sheridan n Jan. 25, 1945, at 4 p.m., one of the most successful public healrh projects in r. Maria C. Freire has been appointed history began. Grand Rapids, Mich., became the first ciry in che world to fluoridate D director of the Office of Technology 0 its drinking water, setting che stage for a dramatic national decline in the race of Transfer (OTT), effective Feb. 5. She dental caviries. Today, established and has headed the office of as water fluoridation technology development at che University of celebrates its 50th Ma ·yland at Baltimore and at the University anniversary, fluoride of Maryland, Baltimore County. Her continues to be dental responsibilities included the effective transfer science's main weapon of technology from academia co industry, in the battle against parenting and licensing acrivities, technical coo th decay. evaluation, legal protection, and che market­ Fluoridation of the ing of i nvenrions and innovations chat arose Grand Rapids water from both campuses. supply launched a 15- "Dr. Freire is uniquely qualified to meet che year study sponsored by challenge of chis imporcanc office," said NIH rhe Public Health director Dr. Harold Varmus, announcing rhe Service, the University appointment. "Her background and of Michigan, and the experience make her the ideal candidate, and ciry of Grand Rapids co we are delighted char she is available co accept monitor che race of chis responsibility." tooth decay among the Freire earned her Ph.D. degree in biophys­ ciry's 30,000 school­ ics ar the University of Virginia in 1981, and children. After j use 11 has completed postgraduate work in immu­ years, scientists Dr. Francis Arnold {l) ofNI DR and Dr. Philip jay ofthe University of nology at the University of Virginia and in announced chat the rare Michigan count colonies ofbacteria in cultures made from the saliva of virology at the University of Tennessee. For of dental cavities had schoolchildren during the Grand Rapids fluoride study. 2 years she held an AAAS congressional dropped more than 60 science fellowship, sponsored by the Bio­ percent. For the first rime in history, tooth decay-the inevitable cause of pain and suffering physical Society and by the American Society for generations of youngsters-was proven to be largely preventable. Today more than 144 for Photobiology, which enabled her to serve million Americans in approximately 10,500 communities drink fluoridated water, one of the (See FREIRE, Page 2) (See FLUORIDATION, Page 4) page2

The Record January 31, 1995

FREIRE APPOINTED TO OTT POST MBRS Investigator Hillyer Grad School Seeks Teachers (Continued from Page 1) Becomes AAAS Fellow The FAES Graduate School at NIH has as a legislative assistant ro Rep. Norman Y. openings for new instructors and new courses Mineta and Sen. John D . Rockefeller, IV. Dr. George V. Hillyer, a professor of (at all levels) in chemistry, physical and Her legislative interests included science pathology and NIGMS Minority Biomedical biomedical sciences, medicine, statistics or technology, higher education, and the ' Research Support (MBRS) Program associate any other area. lf you would like to teach environment. investigator at the University of Puerto Rico one night a week, have ideas for courses not She has received numerous honors and School of Medicine in San Juan, recently was listed in the current catalog, would like to awards, including a grant from rhe National elected a fellow of share specialized knowledge in any scientific Science Foundation in science reacher che American or nonscientific area and/or have the desire to training. She has advised many national and Association for che acquire reaching experience by teaching a new international boards and committees Advancement of course, or participate in the teaching of a including rhe emerging company sec~ion of Science (AAAS). current course, call Lois Kochanski, 6-7976. rhe Biotechnology Industry Organization. He was elected for Even if you are at NIH (or elsewhere) on a OTT serves as the principal agent for the his "pioneering temporary basis, your services are welcome. research insrirurions of the Public Health work on cross­ Nor only can you add "reaching experience" Service-NIH, the Centers for Disease immunity in to your CV, bur you can also be paid for your Control and Prevention, and FDA-in schiscosomiasis and efforts, receive FAES bookstore discounts and carrying our the technology transfer policies fascioliasis and for D G • •v H'll Social Security coverage. A number of FAES of the U.S. government as expressed by careful analysis of r. eorge · i 'Yer instrucrors have written popular textbooks Congress in rhe Federal Technology T ransfer the antigenic determinants both for immu­ based on their courses. 0 Ace of 1986. nity and immunodiagnosis," according ro OTT conduces rhe following activities on AAAS. T his research has been supported by Blue Cross To, Hold Service Day behalf of the PHS intramural research NIAID. Blue Cross/Blue Shield of the National community: assisting in evaluation of Hillyer has been associated with the Capital Area will be on the NIH campus pacenrability and marketability of new University of Puerto Rico system since I 972. Monday, Feb. 6, to assist enrollees who have inventions, obtaining and enforcing domestic During that time, he has served as a professor claims or enrollment problems. A representa­ ~nd foreign patents on inventions made by of immunology and parasitology (1972-1987) tive will be available from 10 a.m. to 1 p.m. rncramural laboratories, marketing and and as chairman of the department of biology on that day in Bldg. 3 I, Conf. Rm. 9 (C licensing patent rights and ocher intellectual (1981-1987) at the Rio Piedras campus. In win~, 6th fl.) armed with a laprop computer prope_rcy to industry, and evaluating requests I 987, he transferred to the medical sciences co d1rectly access the enrollee's records at from 111.tramural scientists that the govern­ campus. Since joining the staff, he has served Blue Cross/Blue Shield headquarters. No ment waive its intellectual property rights co as director of the Laboratory of Parasite appointment is necessary. Assistance will be employee inventions. Immunology and Pathology. Hillyer also was provided on a firsr-come, first-served basis. OTT also administers licensing agreements, responsible for writing che curriculum for rhe his anticipated chat additional service days including royalty administration, helps ~ni~ersity's fir~t intercampus Ph.D. program will be scheduled in the future. 0 agencies administer cooperative research and 1n biology, which began in 1981. development agreements (CRADAs), and His association with MBRS began in 1973, provides policy directives in the field of when he and a colleague wrote the original technology transfer both to PHS personnel The NIH Record MBRS grant application for the University of and to potential technology transfer partners Published biw«kly at Bethesda, Md., by the Editorial Puerto Rico, Rio Piedras campus. He served outside the government. 0 Operuions Branch, Division of Public Information for as the_ director _of t~e school's MBRS program the information ofemployees of the National lnsri,;,tes of Employee Assistance Workshops from tts tncepnon 111 1974 until 1983. Health, Depanment of Heal,h aod Human Services. The Resume on Tuesdays in the VIC Over the past 20 years, he has acted as a con_ttnt is rc:prinrable widlOur permission. Pictures may be mentor to many MBRS participants who have avadab.le on request. Use of funds for prin

The Record January 31, 1995

Teaching Methods Challenged DCRT Hosts Lecture on Gender Article Updates NICHD-Funded Learning Disabilities Research Bias in Education, Feb. 6 "How America's Schools Shortchange Girls: By Robert Bock (S ubtle) Gender Bias in (Science) Education" he "whole language" approach to discrepancy is a clear diagnostic marker for will be addressed by Ors. Myra and David T teaching reading simply does not work LD or can be considered a pathognomic sign Sadker, professors at American University and for children with reading disabilities, while a is at best premature, and at worst invalid," authors of the book Failing at Fairness: How structured, "phonics-based" approach is more Lyon wrote. America's Schools Cheat Girls (Charles likely to help them. T he l.Q./achievemenr The article also notes rhat although schools Scribner's, 1994) in a lecture at Wilson Hall, discrepancy used by many school systems to classify four times as many boys as girls as Bldg. I, on Monday, Feb. 6 at 2 p. m. allocate special educational services is having a reading disability, several studies Extensive research conducted by these rwo probably invalid. Although schools idenrify have shown that boys and girls are equally social scientists and their scudenrs over the four times as many boys as girls as reading likely co be affected. past 20 years indicates chat gender bias in disabled, girls are as likely as boys to have a Next, Lyon summarized N ICHD research schools makes it difficult for girls ro receive reading disability. related to che symptom complex known as an education equal co char received by boys. These are just a few of the major research arcention deficit disorder (ADD). Briefly, That, according co data and conclusions in findings summarized in an article describing their book, may be one reason why fewer the most comprehensive and up-to-date body female students pursue careers in mathematics of learning disabilities (LD) research in or science. existence. T he research, funded since 1985 The vast majority of chil­ The Sadkers documented the existence of by N ICHD, is presented in the January issue dren with reading disabili­ gender bias from the classroom co rhe of the Journal of Child Neurology. boardroom and have developed training "Within the past 10 yea rs, N ICHD research ties /,ack the ability to sepa­ has identified the major cognitive mecha­ nisms underlying dyslexia and other learning rate words into their com­ disabilities and how the assessment of these ponent sounds. mechanisms can help to predict the onset, developmental course, and outcomes of such disorders," wrote the author, Or. G. Reid Lyon, director of extramural research individuals with ADD have extreme difficulty programs in learning disabilities at NICHD's maintaining their attention, seeming co be Human Learning and Behavior Branch. impulsive and co have difficulty sticking with In the article, Lyon summarizes NICHD­ casks for long periods of time. sponsored research on reading and language­ NICHD-sponsored researchers have found related processes, attention disorders, the chat alrhough ADD and reading disability are genetics of learning disabilities and the brain often found in the same persons, neither abnormalities implicated in learning disor­ disorder causes the other. Rather, the two ders. disorders appear to be separate and distinct. Regarding reading disability, it is now However, because reading disability is often known that chis disorder affects at lease I 0 found together with ADD, and because ADD million children, or roughly one child in five. is more likely co occur in males, many more The vast majority of children with reading males than females are idencified as reading disabilities lack the ability to separate words disabled as a comequence of their being into their component sounds, an ability diagnosed with ADD. referred to as phonological awareness. These Ocher research suggests a generic compo­ children also have difficulty recognizing that nent to reading disabilities, with family Drs. Myra and David Sadker letters of the alphabet stand for specific studies showing chat many individuals may speech sounds. Numerous studies have inherit deficits in phonological awareness. programs co combat sexism and sexual shown thac highly structu red, explicit Additional studies link reading disorders co a harassment in more than 40 sraces and instruction in letter-sound correspondences 1s specific site on chromosome 6. overseas. They have directed more than a more effective for teaching these children Based on NJCHD-funded brain imaging dozen federal equity grants, written six books than the "whole language" method. Whole studies, the brains of some people with and more than 75 journal articles. Their language, popular in many school districts, dyslexia appear different chan the brains of work has been published in hundreds of emphasizes the conrexr and inrenr of a body normal readers. In people with dyslexia, the newspapers, including the Washington Post, of rext, rather than individual words and rear portion of the left hemisphere-the left the London Times, che New York Times, and letter sounds. half of the brain- is either smaller than the the Wall Street journal and was the backbone Ocher NICHO-sponsored research has corresponding pare of che right hemisphere, of the recent report from the American called into question the longstanding practice or che rwo hemispheres are che same size. For Association of University Women, "How in many school systems of distinguishing normal readers, the rear portion of the left Schools Shonchange Girls." Among honors berween reading-disabled children who have a hemisphere is larger than the corresponding received by the couple is the American discrepancy berween their overall J.Q. scores portion of che right hemisphere. For dyslexic Educational Research Association's award for and their reading scores and those who do not individuals, the size reduction in the left the best review of research published in the have such a discrepancy. In fact, children hemispheres is most evident in a region in che United States during 199L They have also wich reading disabilities have difficulry with rear of the brain known as the planum appeared on local and national relevision and the skills needed for reading words, regardless cemporale. In addition, neuroimaging studies radio shows. The session, sponsored by of whether or nor they have an I.Q.-reading chat view how che brain processes informa­ DCRT and cosponsored by the NIH women score discrepancy. tion show clear differences between people scientist advisors and the NIH Office of 'The assumption that an aptitude (typically with dyslexia and normal readers. 0 Equal Opportunity, is open co all. 0 assessed using intelligence tescs)-achievemenr page4

The Record January 31, 1995

FLUORIDATION MARKS 50 YEARS CC Gets Good Report Card (Continued from Page 1) The C linical Cencer received high marks ar best public health bargains. Warer fluorida­ che conclusion of che recent Joint Commis­ tion coses an average of only 51 cencs per sion on Accredicacion of Healthcare Organi­ person per year-the price of a candy bar. zations QCAHO) survey. The four-person Over a lifetime, the $38.25 expenditure for survey team spent 3 days examining CC fluoride is less than the average cosc of just policies and procedures, visiting pacienc care one dental filling, about $42. units, and interviewing hundreds of employ­ Research on fluoride and its effects on tooth ees. enamel began in earnest in the early l 930's "The Clinical Cencer will be granted a full under Dr. H. Trendley Dean, a dentist at 3-year accreditation by che Joint Commis­ what was then the National Institute of sion," said Dr. John Gallin, CC d irector. Health. Scientists had observed low decay "This accreditation reflects the consistently rates among people whose drinking water high quality of care chat we provide co our contained high levels of fluoride, a naturally patients as well as the hard work of all of our occurring mineral. Dean provided the first employees in preparing for the survey. The solid evidence linking the amount of fluoride team was very impressed with che quality of in the drinking warer co the incidence of our staff as well as our commirment co che dental decay. These studies provided the institution's biomedical research mission. scientific foundation upon which the The success of the survey is a direct reflection National Institute of Dental Research was Dr. David B. Scott examines the teeth ofa of che quality and effort of each CC and established in l 948, with Dean as ics first Grand Rapids schoolgirl. He was the only institute employee." director. examiner to participate in all 15 years ofthe "The surveyor ream found no deficiencies By the early l 940's, dental scientists Grand Rapids study. He later became the in rhe care we provide to our patients. The concluded that water containing l part per director ofNIDR. only recommendations nor related co patient million fluoride would protect teeth from use of fluoride in community water supplies, care che surveyors offered involved infrastruc­ decay. T h eir theory was pur ro the tesr in toothpaste, and other forms. The most ture problems in our 40-year-old building," 1945, when fluoride was added ro the almost recent survey in 1986-1987 found that said Dr. David K. Henderson, CC deputy fluoride-free water supply of Grand Rapids. American children had 36 percent fewer director for clinical care. Former N[DR director Dr. David Score was cavities than they did ac che beginning of the "The 1994 survey process marked che first an investigator on che Grand Rapids project. 1980's. Thar decline followed a similar drop rime char the survey ream evaluated actual He now recalls, "The most important in the prevalence of cooth decay during rhe performance rarher chan relying scriccly on historical feature of water fluoridation was l 970's. And the news is good for adults the documentation of policies, procedures, that this public health measure simply too-studies show their tooth decay rates are meeting minutes, and ocher reports. The replicated what had already been demon­ also reduced as a result of wacer fluoridation. surveyors wanted co know how well we strated in nature." The Michigan study and Despite these reductions, however, cooch integrated efforts across departmental others carried our during the l 940's and decay remains a problem, particularly for boundaries. T he ream was clearly impressed 1950's confirmed chat when fluoride was chose wich poor oral hygiene and limited with rhe way we approach patient care as a added co community water supplies, decay access co professional den cal care. ream," noced Henderson. rates dropped dramatically. Scott notes, Exaccly how fluoride prevents cavities is not The CC will be surveyed again in 1997. "One of the mosc exciting experiences of my fully understood, but scientists do know that However, scarring in 1994, JCAHO initiated career was observing firsthand che benefits of fluoridated water most benefirs tho,e who interim unannounced surveys for a small fluoridation in the people of Grand Rapids." drink it from b irth, and che protection holds percentage of accredited hospitals. From 1971 through the mid-1980's, three throughout life for persons who continue co "The Clinical Center can stay prepared for national surveys of children's oral health live in fluoridated communities. For che 26 these 'surprise' surveys by continuing our showed a continued decline in dental cavities, million Americans who live in areas wirhout outstanding clinical performance as well as by a trend attributed largely co che widespread central water systems, there are a variety of maintaining up-to-dace policies, procedures, ways to receive and documentation," offered Henderson. fluoride, including The not-for-profit Joint Commission has fluoridated cooth­ functioned for more than 40 years as che pasces, gels, mouth nation's major forum for establishing rinses, and ocher standards for health-care organizarions. It products. Although accredits more than 8,000 hospitals and beneficial, fluoride health-care facilities each year with a mandate from chese sources is to assure quality care for che public. 0 nor as effective as water fluoridation in Stem Cell Processing Explored preventing tooth The field of stem cell cransplanracion has decay. Studies show seen major advances in recent years. To chat, even today, review chose advances and recommend areas children who have for furure research, che NHLBI Bone Marrow always lived in a Transplantation Branch is convening a special fluoridated commu­ 2-day workshop. nity have up to 25 The "Seem Cell Processing Workshop" will percent less decay be held Feb. 16-17 in Lister Hill Auditorium, than youngsters who Bldg. 38A. About 25 expercs from che have never lived in a United Stares and Canada will speak. To fluoridated area. 0 register or obrain more information, call Water flow is adjusted at the Grand Rapids water filtration plant. Holly Dodge, (301) 468-6555, exc. 2060. 0 page 5

The Record January 31 , 1995

NIA/D's Harold Ginsberg Honored by Bristol-Myers Squibb NINOS Receives $1 .8 Million Gift By Greg Folkers The largest donation ever made co NINDS For rhe second consecmive year, the new insights into adenovirus genetics, provided a $1.8 million bonus for research prestigious Bristol-Myers Squibb Award for transcription, replication and gene expres­ into neurological disorders. "This was Distinguished Achievement in Infectious sion. He demonscrared, for example, char completely unexpected," said NINOS Disease Research has been awarded to a only early gene expression is required to Executive Officer Richard L. Sherbert, Jr., of scientist from the NIAID Laboratory of produce the lung pathology of adenovirus che bequest made by Kenneth S. Harrison, Infectious Diseases (LID). pneumonia, and chat che early region 3 of rhe who died in August 1992. Harrison, who Dr. Harold S. Ginsberg, an expert in the adenovirus genome plays an imporcanr role in had no known LID and professor emeritus of microbiology the latency of the virus. connection with and medicine at Columbia University's Ginsberg's arrival gave LID staff "the NIH, m ired in College of Physicians and Surgeons, received oppormniry to observe, close up, a master 1969 as chief the award for a lifetime of work devoted co experimentalist proceeding against a previ­ counsel of rhe U.S. describing the genetic makeup of ously elusive and complex target," noted Coast Guard and adenoviruses and their role in human Chanock. "Many molecular virologists was a rear admiral respiratory disease. He currencly conduces preface their granr in che Coast Guard research into adenovirus and simian ATOS proposals with a Reserve. "The pathogenesis ar NIAID's Twinbrook facility. statement of their money was left in Ginsberg succeeds Dr. Robert M. Chanock, ultimate dedication honor of Admiral LID chief, as che recipient of rhe Bristol­ to unraveling the Harrison's wife, Myers award. The rwo ocher recipients of rhe mysteries of Anica B. Harrison," ~ •V~ Sherbert said. "le award have been NWD grantees: Dr. f'.,~• .·~...... I pathogenesis, but Kenneth S. Harrison Bernard Fields of Harvard University and Dr. fa very few ever was Admiral Barry Bloom of Albert Einstein University. deliver. Dr. Harrison's wish char the funds be used co aid "D r. Ginsberg has made enormous ~ Ginsberg is one of in finding the causes of and a cure for contributions to viral research, notably in our che very few!" peripheral neuropathy, che disease which understanding of the molecular virology and Ginsberg earned eventually caused his wife's death." genetics of adenoviruses and their pathogen­ \ his medical degree A native of Maryland, Harrison was a esis in a host," said Dr. Anthony Fauci, Dr. Harold S. Ginsberg at Tulane Univer- resident of Alexandria for many years. He NTATD director. "This award is a cescamenc sity School of began a civil service career with rhe federal co Dr. Ginsberg's extraordinary career and is Medicine in 1941. After clinical training ar another milestone in che proud hisrory of rhe Mallory Institute and Boston City Hospital, Laboracory of Infectious Diseases." he served as a physician in the U.S. Army, "D r. Ginsberg's career, which has spanned and then resumed his academic career at what 50 years without diminution of excellence or was then Rockefeller lnscirure in New York. vigor, is an inspiration to younger scientists," In the 1950's, he continued his research into said Chanock. "Throughout, he has influenza viruses and ARD ar Case Western remained a major concributor rn our Reserve University and, in 1960, became understanding of an important family of chairman of the department of microbiology viruses." at che University of Pennsylvania. In 1973, In che l 950's, Ginsberg was rhe first ro he moved ro Columbia co become chairman demonstrate chat adenoviruses cause certain of the microbiology department there. infections, including acute respiratory disease Ginsberg joined NIAID in 1993. (ARD) and a form of pneumonia char He is a member of the National Academy of Attorney William F. King (c) presents a check commonly strikes ch ildren. Subsequencly, he Sciences and the Institute of Medicine. He for $1.8 million from the estate ofKenneth S. characterized che genome of various received che U.S. Medal of Honor for his Harrison for neurological research to NINDS adenoviruses and described che molecular discovery char rhe use of plasma was causing director Dr. Zach W Hall and deputy director mechanisms used by these agents to injure severe hepatitis in wounded soldiers. He also Dr. Patricia A. Grady. hose cells and cause disease. His work paved has been awarded che Academy Medal from che way for development of subunit vaccines the New York Academy of Science, the government in the J 920's and attended law to prevenr adenovirus infections and for new Physicians and Surgeons Distinguished school during che evenings. During the rrearmencs, and also shed light on the role of Service Award, rhe Oucsranding Professor 1930's, he worked for the War Department, ocher viruses in tumor formation. Award from che U niversity of Pennsylvania was appointed a special attorney with the His characterization of adenovirus genes and chc Humboldt Award for the senior U.S. Bureau of Cuscoms, and lacer served in the and proteins has enabled other researchers co scientist category. office of the general counsel of rhe Treasury use these viruses as vectors fo r delivering Ginsberg helped found che American Department. He rook over as chief counsel of healthy genes rn patients with cystic fibrosis Society of Virology, and served as ics the Coast Guard in 1938 in a civilian capacity and ocher inherited diseases. president from 1983 co 1984 and as editor of and served in the same position on active duty "Dr. Ginsberg is a gencleman scientist of rhejournal of Virology from 1979 co 1984. D during World War Tl. After the war, he the old school- he always has been very returned ro civilian status bm maintained his generous with his reagents and his ideas, and USUHS Performance Study commission in the Coast Guard Reserve. In his acknowledgment of rhe roles of ocher Recruits Male Volunteers l 956 he was appointed co the rank of rear people," says virologist Dr. Janer Hardey of The USUHS deparrment of medical and admiral, che first officer in rhe Coast Guard NIAID's Laboratory of lmmunopathology. clinical psychology needs healthy male, Reserve co attain chat rank. He retired from "He is uncommonly accomplished in both nonsmoking volunreers, between ages 21-45, the reserve in 1961. classical virology and molecular virology." for a 2 1/ 2-hour scudy of che effects of noise "The inscirure will create an appropriate In 1985, Ginsberg spent a sabbatical year in on performance. Volunteers will be paid memorial chat will bear Mrs. Harrison's che LID to study the pathogenesis of $30. Call Laura, (301) 295-3263. D name," Sherbert said. "One of the possibili­ adenovirus type 5 in cotton rats, providing ties is an annual lectureship." D page6

The Record January 31, 1995

SATURDAYS AT NIH PROVED FUN, EDUCATIONAL FOR STUDENTS (Continued from Page 1) up their laboratory findings. They had spent Someone else remarked char "ar school, chey 2 months attending the Saturday School run can't afford equipment, so we have to watch by the NIH Office of Education. The teachers do experiments," a far cry from what students, called "the best of the best" by Dr. goes on in the Saturday School laboratory. Ma1y McCormick who ran the program, had Many of che students hope co work in NIH been nominated for the program by their laboratories next summer. So, on one schools. Saturday, after rhe students had spent the During their eight Saturdays on the morning in the lab, Gloria Seelman of OE campus, the studenrs became expert at basic calked about how to write a resume and the laboratory procedures-pipetting, loading importance of writing a cover letter chat and running gels, transforming and plating would catch the eye of a lab chief. "You may bacteria-and learned ro plot and analyze never get an interview," she cold rhe students, daca. They grew comfortable evaluating and "so the cover letter becomes the interview. discussing sciemific papers and popular Think how you would be as an employee. literature about science, and they could talk You wane chem to choose you." knowledgeably about the strengcbs and merits Seclman had the students take a scab at of leading-edge technologies such as PCR. writing a cover letter. Then they were told to Students at OE's Saturday School took "The atmosphere was relaxed for the kids," exchange letters. The students "praised and advantage of NJH's well-outfitted laboratories. said Judy Price, a Watkins Mill High School polished" each ocher's letters, and then Seelman asked who had read strongly by his traveling companion for a really good cover letter. pulling off the road, turning on the lights in Everyone agreed that the che car and waking his companion-just so letter that was read aloud he could jot down his ideas. was excellent, because the Five students talked about an article char writer had used good, explained how PCR was helping co establish nonbureaucracic expressions whether a demist had or had nor transmitted and because her words the AIDS virus to his patients. Four ochers effectively conveyed her described a new sequencing technique human qualities. developed by Tom Caskey and then com­ When the students pared its strengths and weaknesses to those of returned that afternoon to PCR and RFLP technologies. the lab, it was rime to take McCormick then showed the students an their rest tubes out of the article in Business Week, "Gene Machine PCR thermocycler. They Starrs Cloning Cash." It was rife with errors \ added dyes co che samples and che students loved finding the mosc J and then loaded chem onto egregious of them. gels. With all the gels This was just an average day at the Saturday During their eight Saturdays on the campus, the students became running, the class headed School. On ocher Saturdays, the students expert at basic laboratory procedures-pipetting, loading and upstairs to one of the learned how co search che biomedical running gels, transforming and plating bacteria. classrooms to talk about literature and how co get into NIH Edner, an teacher who helped wirh the program. She is their reading assignments. OE electronic bulletin board. The mix of lab a graduate of another OE program, which In groups of rwo, three, or more, the work, science dogma, discussions of strategies included a year-long research experience in an students presented the meat of articles they for success, and new friendships was a good NlH laborarnry. "From a reachds point of had read. Two girls talked about Kary and srimulacing one. Said one student, view, the siruarion was perfect. The course Mullis, the developer of PCR who had gotten "Everybody wanted co be here, and char was screeched their level bur wasn't inrimidacing, his inspiration for the revolucionary technol­ the best part." and this is a positive refleccion on how they ogy while driving home late one night. They Ir is nor an exaggeration to say that the were instructed." discussed the irony of how, in this pivotal graduation ceremony on che last Saturday, The students were uniformly enthusiastic moment for science, Mullis was berated which was attended by some 100 parents, about the program. "Awesome," said one. "Worch getting up on Saturdays," said another. "It was ... likc... the perfect learning experience," said a third. Many of the students in the program came knowing that biomedical science was for them, bur ochers were resting the waters, and they found them to be ideal. One girl who had been eager to be an environmental engineer is now set on a career in biomedi­ cine. "The experience totally changed what I want to do," she said, characterizing the 8 weeks as wonderful. "They answered every question we asked. They didn't just write off our questions che way they do in school." "The teachers here are funny," said another enthusiastic student. "It's not like regular school. Ir's like a laid-back school." Shown above with Office ofEducation director Dr. Michael Fordis (front, r), 25 students spent 2 months attending a recent session ofthe Saturday School run by OE. page 7

The Record January 31, 1995 siblings, and friends, was reminiscent of a Fordis could not disguise his pleasure when the chairperson of che molecular biology J 960's-style lovefesr. Everyone was smiling speaking about the large number of students deparcment here. My position apparently and everyone was thanking everyone else. who, having graduated from che program, go was unheard of for a freshman ... Needless to Many students turned to McCormick during on co apply for research internships ac NIH. say I am quire excited and would like to the picture-raking session to express their The program has now been running for 4 personally thank you for giving me rhe heartfelt thanks co her. One parent remarked years. le was sec up through a collaboration opportunity co gee my foot in the research that ir is "so much fun to bring out the besr between OE and Drs. John Ruffin and door." in people. This program obviously does thar. William Coleman (an NIH scientist) in what "There is," said one of rhe fathers at rhe Ir should be done more often." was then called che Office of Minority Health graduation ceremony, "an expression chat Dr. M ichael Fordis, OE direct.er, expressed Research. Since the second year, che program luck is where preparation meets opportunity. appreciation co the parents for participaring has been cosponsored by OE and che Office All these kids prepared themselves for this­ and for "making the sacrifices chat were of Research on Women's Health, directed by chey didn'r know chey were doing ic. This necessary to get the children to NIH each Dr. Vivian Pinn. has been a unique opportunity and one that Saturday." Fordis congratulated the students Recencly, Seelman received an e-mail was well-timed. l chink you scarred some­ on rheir accomplishments. "From our message from a student who had been in the thing." 0 vantage point," he said, "the students seem co program lase year. "l hope you still recognize ger more enthusiastic each year. We hope to (my) name, but, in case you don't, I was in Men Sought for Study keep pace with your enthusiasm and provide the (Saturday School) last fall. I was one of NIMH requires healthy men between ages experiences that give you a sense of che che few who got up really early on Saturday 20 and 50 for a study of brain function and tremendous excitement that we feel when we mornings to tinker around with ONA. structure, using PET and MRI techniques. peer into rhe unknown-the excitement we Currently I am attending Lehigh University, The PET scan involves exposure co an find in biomedical research. Our hope is to majoring in molecular biology... The reason I amount of cadiacion that is within both NIH encourage students to study science and to decided co write was co cell you what this and FDA guidelines. Study takes place on become scientifically literate citizens, even program helped me achieve.. .I have been the Bethesda campus. Volunteers will be those who do not choose scientific careers." named a paid research assistant in the lab of paid. If interested, call 2-3682. D NIMH's Career Opportunities in Research Program Comes of Age he corning-of-age of a unique NIMH in the department of human T program chat nurtures undergraduate service stud ies in Cornell students from colleges with predominancly University's College of Human minority enrollments was evident at the Ecology; annual COR (Career Opportunities in * Or. Margaret Murray, a Research) colloquium held recencly. Dr. 1987 graduate who went on to Denise Person, one of the program's first complete medical school at graduates more than a decade earlier, was Albert Einstein College of back at the event-but chis rime as a talent Medicine, conducted a study scout on a recruiting mission for her on AIDS in Zimbabwe, and is university. Now a psychology faculty now doing a pediatric resi­ member ac Pennsylvania Scace University, she dency at Monrefiore Medical conduces research on cognitive aspects of Center in the South Bronx; aging, specifically the effects of chronic * Dr. Jacqueline Huey, a worry. 1988 graduate from Grambling Under COR, selected third- and fourth­ Scare University, who is now a year honors undergraduates are assigned Eliwbeth Bruneau (c) a psychology undergraduate at Hunter sociologist ac Wayne State faculty mentors who provide hands-on College in New York, presents her poster "Cerebral Arymmetry University studying criminol­ training aimed at preparing chem for graduate and Olfaction in Infancy," at the recent COR colloquium. Other ogy and problems facing study in neuroscience and behavioral science attendees include (from I) NJMH Deputy Associate Director far minority women; disciplines relevant to mental health fields. Special Populations Sherman Ragland, Hunter College COR * Dr. Angela Shannon, a So far, about 80 percent of COR students Associate Lily jieu, Wayne State physiology faculty mentor Dr. 1984 cum !mule graduate from have gone on to graduate school. Robin Barraco, and Dr. Harry June of Indiana University. Spelman College, now a Seasoned observers noted a maturing in che postgraduate resident in child scientific caliber of students' research and faculty mentors at the 3-day event, held and adolescent psychiatry ar Emory Univer­ presented at the colloquium. "It's amazing in Washington, D.C. More than 70 poster sity, who does research on violence in how advanced these students are," remarked and slide presentations spanned copies from children. Sherman Ragland, NIMH deputy associate basic neurophysiology (e.g., "Prolactin The colloquium also featured a plenary talk director for special populations. "The kinds Release from rwo Regions of the Rat Amerior by NIMH acting director Dr. Rex Cowdry, of research they' re doing is second-year Pituitary Gland in Response to Hypotha­ and a keynote address by neuroscientist Dr. graduate school level, not whac one sees from lamic Factors") to sociology and social work James Townsel of Meharry Medical College. the typical undergraduate student." (e.g., "Effect of Shelter Life on che Family lmpressed with the level of student involve­ The Office for Special Populations, headed Planning Activities of its Residents"). ment, Ragland said he looks forward to the by NIMH associate director Dr. Delores Spotlighted as role models at the event were day when COR graduates are che directors of Parron, has sponsored rhe program (called the 23 graduates of the program-

The Record January 3 I, 1995

KING COMMEMORATION STRESSES 'EVERYONE CAN SERVE' life. The prime virtue is courage, because (Continued from Page 1) chat's what makes all rhe other virtues possible." was not a place you would call diverse. familiar mainly co music aficionados, Leffall Earlier in che program, both Leffall and "Despite the insularity," Varmus continued, was cold chat such a note is one whose riming Varmus had mentioned NIH's responsibility some Amherst students began in 1958-59 to does noc affect che rhychm of che bar. A co improve campus diversity, something King learn about the status of grace note, he cold che spoke about o n a national level. Black students in che South audience, is not really part of "1 am proud of the way most of us at NlH and about King's "peaceful, the sheet music, hue is work-shoulder co shoulder, Black and buc determined efforts to put "something a lirde exrra, a white, males and female," said Varmus, "but an end to che practice of nicery, an ornament," made I'm also sometimes frankly ashamed of the segregation." Varmus said all the more special because discrimination 1 hear about, rhe anger, growing knowledge about che musician has performed ic harassment, suspicion, il l will. Ac the NIH King's work inspired him wichouc instruction or we are blessed wich a noble purpose- medical and a few of his friends co provocarion ...jusr because. science co prevent sickness and death. All of pack cheir own picket signs, Tying musical improvisa­ us, regardless of race or sex or inrelleccual drive down on buses ro tion to his own area of ability, have a contribution to make in chis Washingcon from New The Coppin State Choir, which expertise-and chat of che noble goal." England and join a White performed to rave reviews last year NIH community, Leffall "If NTH can lead in research," Leffall House procesc march of at NIH, makes joyful noises described rhe feelings of a commented, "it can lead in diversity. le can about 200 students on Apr. during 1995 '.r King celebration. cancer pacienc he had rreaced. lead in inclusiveness. .. Respect and crust are 15, 1960. The pacienr cold Leffall she nor given in perpetuity; they muse be earned "Ou r I-day protest in Washington is now no longer wanted co be broughr co her every day." largely- perhaps appropriately- forgotten by radiation therapy sessions by che person who Echoing those sentiments, Broder com­ all bur a few of us who were there," Varmus had been regularly bringing her because, the mented on King's legacy, che country's said. "le was surely one of the smallest aces of patient said , "I can cell chac [che friend] progress coward achieving it and NJH's a great civil war. Bur, it was also an indicacor doesn't really want ro do iL" unfinished business. of changes occurring in the minds of our Leffall said the audience should learn from "We are maturing as a nation," he said, citizens. It prophesied the changes in our the patient's words: "The "when we celebrate che life of behavior that have occurred in che North as recipient of a favor almost a peacemaker, a man who well as the Souch-changes that Dr. King put always knows whether you symbolizes the belief char no in morion almost singlehandedly. As a result did it because you wanted co one is born co crawl and rhac our society is more open. Places like Amherst or whether you did it because each of us can, with a licd e look a lot different today than they did in my you had co do it. help, fly. Our cheme today day." "That's what the Cannon should be 'Help Someone In a unique addition to che program, was talking about," che Fly.' remarks were offered in sign language by surgeon continued. "In our "We at the National NIOCD personnel assistant Lori E. Ingram, lives, we muse be willing co [nstitutes of Heal ch use who is deaf. "We must be interested in doing do someth ing just a lirde science and the scientific more chan just our jobs," she signed, while an extra-perform that grace NJH's Preschool Song and Dance method co alleviate human interpreter spoke the words for the audience. nore- to lee people know Troupe performs a medley of suffering and generate "We must be concerned for our fellow man chat we genuinely care about "Rainbow" selections. knowledge. Our job is and not ignore che homeless and needy in our chem." certainly noc done if che benefits of chat communities." Professor and chairman for 25 years of the knowledge do not reach all Amer.icans." Providing messages in music and dance department of surgery ac Howard University, Concluding his remarks, Vannus chal­ were che Coppin Seate College Choir, which Leffall has devoted his professional life ro the lenged rhe audience: "Ask you rself why we made an u nprecedented return command study of cancer, especially as ic affects African have public meetings like this co commemo­ performance co NIH; and che NIH Preschool Americans. He was introduced ac che rate Dr. King when no meetings commemo­ Song and Dance T roupe, which presented a program by NCI director Dr. Samuel Broder, rate our honored presidents Lincoln and medley of "Rainbow" songs using colorful who called LeffalJ a personal friend and Washingron. scarves. estimated char the professor of surgery had "The reason we have them for Dr. King," "Every color in the rainbow is precious," taught more than 3,500 medical students and he said, "is because their work is done and his sang the coddlers, who themselves formed a trained more chan 150 general surgeons. is noL People have seen the Promised Land colorful rainbow represenring nationalities A distinguished scholar, milicary veteran buc we haven't arrived there yec." 0 such as India, Russia and China. and physician who said he has wirnessed rhe Lean Females Needed Ei.plaining that the children's words should "human condition in peril and seen demon­ inspire the audience, keynote speaker Or. strations of courage beyond description," Healthy, lean or very chin females ages 18- LaSalle Leffall, Jr., said ic is cime for all Leffall shared his own ideas on King and 3 5 with regular menstrual cycles are needed people to perform a "grace note." Leffall what constitutes a valuable life. for a study of the effects of fasting for 72 spoke of a long-ago conversation wich rhe lace "To see someone in need of help," he said, hours on reproductive hormone function. jazz musician Julian "Cannonball" Adderly "and to give aid, not expecting any enco­ Volunteers muse be nonsmokers on no during which che surgeon, oncologist and mium or remuneration, just a deep, incense medications, including oral contraceptives, unofficial student of jazz terminology personal sarisfacrion of knowing that you did willing co spend 4 days as an inpatient twice, described how he learned che definition of a the right thing. ls char not man's ultimate 3 months apart. Women in each of these grace note. Leffall said he and Adderly were gift? categories will be studied: sedentary lifestyle listen ing to a recording of "Lush Life" by jazz "In life, what's important is nor so much (no regular exercise), moderate runners (I 0- great John Col crane when chc Cannon asked superior intellect or even great charisma, bur 25 miles per week throughout che year), and Leffall 's opinion of che "grace noce" during a racher ... parience and scamina and equanimity runners logging more than 25 miles per week. particular sequence. Puzzled wich che rcrm under pressure. That's whar's important in Volunteers will be reimbursed for participa­ tion. Call Dr. Ruben Alvero, 6-9854. 0 page 9

The Record January 3 1. 1995

Japan Society for Lipid Nutrition Honors NIAAA's Lands Promocion of Science, he traveled in 1980 co The Japan Society for Lipid Nurricion Japan, where he worked in chree laboracories recendy announced creation of the new and gave 30 leccures during a 6-month "Lands Research Award," named for D r. sabbacical. W.E.M. Lands, NIAAA's director of basic His work and chat of o chers today enables research, in recognirion of his contributions scientists co estimate from dietary informa­ co research on lipid biochemistry and tion the impact of dietary faery acids on tissue nurricion. The society will presenc the award eicosanoid precursors and antagonists. annually to Japanese scientists who excel in Similarly, dietary composition can now be chat research area. estimated from plasma faery acid patterns. One of the world's 1,000 most-cited Lands' longstanding interest in tissue scientists 1965-1978, Lands has published integriry sec che stage for focusing at NIAAA more than 150 articles in refereed journals, 7 on the impact of alcohol on body and brain books, more than 60 chapters and reviews in tissues. Since his 1990 appointment as books, and more than 60 abstracts and director of che Division of Basic Research, he miscellaneous reporcs. Since 1980, he has has overseen both the Biomedical Research given more than 150 invited leccures. and che Neuroscience and Behavioral Previous honors include the American Oil Research branches, including approximately 400 extramural research projects annually. Chemists Society Bond Gold Medal, the Dr. Enoch Gordis (1), NIAAA director, "The ability of alcohol co perturb a wide Glycerine Research Award, a Pfizer Biomedi­ congratulates Dr. W. E.M. Lands, director, variety of molecular and cellular processes cal Research Award, an American Medical Division of Basic Research, on award that offers a fascinating challenge for biomedical Association Distinguished Lectureship, and a bears his name. Canadian Society of Nucri tional Science researchers," Lands said. Lectureship. Lands was a fellow of the Japan Lipid N ucricion. "Our invescigarors are exploring how Society for the Promotion of Science in 1980 From 1960 th rough 1980, research in alcohol alters molecular mediators of and is a fellow of the American Association Lands' University of Michigan laboratory cognition and behavior and characterizing for the Advancement of Science and an focused on glycerolipid mecabolism, specific genes and gene produces char account honorary member of che Australian Rheuma­ proscaglandin biochemistry, cell biology of for individual differences in vulnerability to tism Society. With establishment of the membrane lipids, and che effects of n-3 faery alcohol. As we learn rhe mechanisms for award in his name, he also was named an acids on (n-6) mediated events. O n an rhese processes, the promise of more effecrive honorary member in che Japan Society for invitation from che Japan Society for che interventions becomes more certain." 0

nolice ffl7 Dunham is no stranger to a medical l'rofile ~ environment. In 1980, she made che newspapers when the mayor of New Haven Ofc. Shelley Dunham has been with the swore her in as a special constable for che NIH Police force for 8 years. She was city of New Haven-just 2 days after she recently assigned as community policing delivered her first child. She was assigned to officer for Bldgs. 6 and 21 and Yale New Haven Hospital where joint community policing she was lead officer for the night officer for Bldg. 10. She has shift. T his was no small fear, more than 20 yea.rs experience wirh just eight officers protecting in law enforcement. an 820-bed hospital, including Currently residing in Fairfax two psychiatric wards, an County, Va., she was reared in emergency room and approxi­ che Northern Virginia area. mately five city blocks of streets She attended McLean High encompassing the hospital. School where she participated During her tenure at Yale, she in field hockey, sofrball and had some memorable moments, basketball. Afcer graduating including providing security for from high school, she attended such VIPs as actor Paul Newman Dr. Steven M . Schnittman, assistant director far clinical research in NIA/D's Division of the University of New Haven Oft. Shelley Dunham when he visited the hospital in in Wesr Haven, Conn., where connection with his camp for AIDS Therapeutics Research Program, has been she received a degree in criminal justice terminally ill children, and Patricia Hearse, elected to fellowship in the Infectious Diseases adminiscracion. when she had her first child. In one Society ofAmerica, which honors nationally Dunham returned co Virginia after interesting case, for which her work was recognized researchers or leaders in the field of graduating from college and worked for a recognized by che director, Dunham broke infectious disease. The society cited Schnittman 's previous work as a senior staff private security agency on special assignment up a ring of teenagers who were using in Baltimore for 3 months. She then went co volunteer uniforms co gain after-hours access fellow in NIA!D's Laboratory of lmmunoregulation, where he made major Hecht Co. and Bloomingdales, where she was co the hospital to pilfer and sell narcotics. hired as a score detecrive supervisor and was She also arccnded the Conneccicuc Scace contributions to the understanding of how the human immunodeficiency virus (HIV) recognized numerous rimes fo r her outstand­ Training Academy in Meriden, Conn., and undermines the immune system, as well as his ing work. was certified in 1982 by che lncernacional recent leadership in finding new approaches to In June 1979, she relocated co Connecticut, Association of Hospital Security. She began where she worked as a liaison between the her career with the federal government in treatment ofpeople with HIV infection through NIAID's HIV clinical trials program. Southern New England Telephone Co. and a December 1987, when she relocated co private security firm. She met her husband, Northern Virginia so chat her children could David, while living in Connecticut. be closer co their grandparents. page lO

The Record January 31, 1995

The NIH Life Management Intern Program Henken Joins GA Program Sciences Announces 1995 Recruitment Dr. Deborah Henken has joined the G rants Education Associate Program in the NIH Office o( The Division of Career Resources and che Extramural Research. This program provides Connection administrative training committee announce a wide range of training experiences in the application period for the 1995 Manage­ extramural science administration. If you are concerned with the state of ment Intern (MI) Program from Feb. 13 Henken received her Ph.D. in experimental science educacjon in rhe nation today, now until Mar. 13. The program is designed to psychology from Dalhousie University where is your chance co voice your opinions on a prepare individuals demonstrating high she examined the set of guidelines chat seek to improve potential for careers in administrative regenerative science reaching. management at NIH. response of The National Academy of Sciences (NAS) To be eligible to apply for the MI program, axocomized recencly released its draft National Science applicants must be U.S. citizens; be willing co neurons in rhc Education Standards. The National work fulltime; be eligible for an outstanding goldfish visual Research Council (NRC), rhe principal scholar appointment or be a current federal system. She operating agency of NAS, is seeking review employee eligible for a GS-5 level or above or continued her and comments on rhe standards from the wage grade equivalent; and be currently studies in nervous anyone interested in contributing to employed in either a career or career­ system plasticity as shaping the final standards. According to conditional appointment or eligible for a postdoctoral NRC, rhe purposes of the review are co: reinstatement ar the GS-5, 7, or 9 level. fellow in the "ensure char rhe intended messages are (DHHS employees must currently be a GS-5 department of communicated clearly; ensure char there is or above; applicants cannot be promoted into Dr. Deborah Henken anatomy at the consistency throughout the document; and the program.) Medical College of alert us ro perceived problems in the drafc." If currencly a nonstatus employee, applicant Pennsylvania. There, she examined alter­ Once the review process is complete, the must be eligible for an oucsranding scholar ations in neuropeptide gene expression final version of the standards will be appointment or some ocher type of non­ following injury to the peripheral and central published lacer rhis year. competitive appointment such as 30 percent processes of sensory ganglion neurons in the The standards ace divided into four disabled veteran, schedule A appointment, tat. sections: science reaching standards, VRA appointment, etc. Upon completion of her postdoctoral standards for the professsional development To qualify for consideration under the studies, she joined the intramural program of of teachers of science, assessment in science "outstanding scholar" provisions, you must NINOS in the Laboratory of Experimental education, and science content standards. be a college graduate and have a grade-point Neuropathology, where foe the lase 5 years Reviewers may comment on one or more average of 3.45 or above on a 4.0 scale, for all she has conducted an independent project of chose sections. The largest section is the undergraduate course work, or have gradu­ examining the neurobiological responses of science content standards, which, according ated in the upper 10 percent of your college herpes simplex virus (HSY) infection in the to the draft standards, "outline what or university or major university subdivision sensory ganglia of the mouse. Henken students should know, understand, and be (e.g., college of business administration or demonstrated that one response of the ganglia able to do in natural science." T he drafters school of engineering). GPAs can be rounded to HSY invasion is the mounting of a state chat NAS does not asswne that in che following manner: a 3.44 is rounded neuronal sprouting response as seen by everyone will learn at the same race or in the down co a 3.4; a 3.45 is rounded up co 3.5. immunocycochemical and ultrastrucrural same manner, bur it does expect that all GPA must be documented by listing all criteria. students will achieve the level of knowledge undergraduate courses completed on form Although Henken will miss being involved and understanding described in the OPM 1170-17, List of College Courses and in che intramural NIH program, she is standards. Certificate of Scholastic Achievement. looking forward to new challenges and rhe According to Dr. Bruce Fuchs, senior Positions are offered at the GS-5, 7 and 9 opportunity to serve NLH's extramural science advisor in the NIH Office of levels. Applicants above the GS-9 level will programs. D Science Education Policy, "It is important be required to accept voluntary downgrades, for the broader scientific community to give bur may be eligible co retain their salary. Judo Class Resumes feedback [to NAS] as to whether they are on Additional information on minimum The NIH Judo Club will start its next the right track with these standards." He qualifications for DHHS and non-DHHS beginners class on Tuesday, Feb. 7 ac the encourages all chose in the NIH community employees is offered in the application Malone Judo Center in Bldg. 31 C. The class who have an interest in science education to package available beginning Feb. 8 at the will run every Tuesday and Thursday evening participate in this important review process. Division of Career Resources, Bldg. 3 I, Rm. from 6:15 ro 7:30 for 6 weeks. T he cost is The period for public comments ends B3CI 5 and selected NIH personnel offices $35. Students will be encouraged to Feb. 28. OSEP has many extra copies of and off-sire work locations such as rhe continue as regular members ot the club the standards and che comment forms. If Parklawn Training Center, FCRDC and when the class is completed. For more you are interested in getting chis material, NIEHS. information, call Doug Dolan, 652-4328, or or if you have questions, call 2-2469. MI program information sessions have been Scephanie Harrison, 6-9490. D scheduled for rhe following dates and times: FAES Music Series Continues Drug Trials Need Volunteers The FAES announces the remaining Feb. 8 2-3 p.m. 31/C Wing/Conf Rm. 7 Healthy volunteers ages 18-75 ace sought concerts in its 1994-1995 Concert Series: Feb. 9 1-2 p. m. EPN!Conf Rm. H ro participate in studies involving two drugs, Feb. 12, Lilya Zilberstein, piano; Mar. 5, Feb. 10 1-2 p.m. Pkln./Maryland Rm. idazoxan and echoxyidazoxan. These drugs Mischa Maisky, cello; and Mar. 19, Feb. 15 1-2 p.m. Westwood/Rm. 428 are being used as pharmacological tools co Borromeo String Quartet. Concerts are held Feb. 16 1-2 p. m. CC/Marnr Auditorium undersrand the alpha-2 system in the brain at 4 on Sunday afternoons in Masur Audito­ better. These are infusion srndies that rium. Tickers at rhe door arc $20, cash or All potential applicants are encouraged ro involve overnight stays in the Clinical check; postdoctoral fellows and students pay attend these sessions. For more information, Center. Volunteers will be compensated. If $10. For more information, call 6-7975. D call Carol Storm, 6-2403. D interested, call Libby Jolkovsky, 2-4926. D page 11

The Record January 31, 1995 TRAINING TIPS Skills Development Offered Gladys Whitted Ends NIH Career Gladys Atkinson Whitted has retired from The Administrative Skills Development The Division of Workforce NIH after a career here chat began in 1976. Curriculum is being offered in 1995. The Development, OHRM, offers She scarred her career in the District of curriculum is open co all NIH administrative the following courses: Columbia as a nursing assistant, working support staff in one-grade-interval jobs who with mentally retarded children. In 1964, Courses and Programs Starting Dates have ICD approval and funds authorization. she accepted a position as documents clerk Management and Supervisory, 6-6211 After attending initial information sessions with che District's motor vehicles safety Preventing Sexual Harassment a, NIH 2/9 with their supervisors, all participants will A"itudes: How They Affect cake part in an intake workshop, "Planning responsibility division, where she suspended tags and permits of drivers found in noncom­ Productivity in Workplace 2/14 for Career Advancement for Adminisrrarive Managing ConOict in the Workplace 2/22 pl iance wich D.C. safety laws. She quickly Support Scaff." Participants will use data Interacting with Difficult Employees 2/23 advanced ro che position of examiner with from professionally administered assessments Congressional Operations Workshop 3/ I 3 responsibility for reviewing insurance lncroduction ro Supervision 3/20 co formulate individual development plans. certificates. Practical Approaches ro Stress 3/28 These plans, approved by participants' Whitted resigned her position with the supervisors and personnel offices, will guide EEO Training, 6-6211 District and rook a job with the U.S. curriculum participants through che program. Preveming Sexual Harassmem ar N(H Department of Agriculture. There she served for All Employees 2/9 A minimum of six courses must be completed in 3 years co receive a certificate of comple­ in numerous capacities including budget Special Courses, 6-6211 assistant, office manager, and purchasing tion. Ac least two courses must be taken each NIH Retirement Seminar 2/13 agent. In 1976, she left Agriculture for Privacy Act Seminar 3/23 year. greener pastures at NIH. Practical Approaches to $((cs, 3/28 All interested administrative support staff Within a 3-year period here, Whitted rose and their supervisors should attend a Administrative Systems, 6-6211 rhrough the ranks from purchasing agent to preliminary information session hosted by the Delegated Acquisition Training Program 3/6 procurement agent, and supervisory procure­ Domestic Travel 3/1 Division of Workforce Development, ment agent. In 1979, she was selected to Foreign Travel 2/23 OHRM. The information sessions will be Basic Time and Anendance 2/7 held as follows: serve as small and disadvantaged business Introduction to N IH Property Management 3120 utilization specialist (SAD BUS) for the Feb. 23 11:30 a.m.- 12:30 p.m. WW, Rm. 428 intramural research Division of Procurement. Administrative and Skills Developmmt, 6-6211 Feb. 24 11:30 a.m.- 12:30 p.m. Pkln., Conf. Rm. E As a SADBUS, Whitted planned, pro­ Proofreading Skills 3/ I 4 Feb. 28 11 :30 a.m.-12:30 p.m. EPN, Conf. Rm. DIE How to Write & Publish Scientific Papers 3/2 Mar. I 11:30 a.m.-12:30 p.m. 31C, Conf. Rm. 8 moted, and recommended procurement opporcu nities for small businesses, socially Personal Computing, 6-6211 Mar. 7 10:30- 11 :30 a.m. Masur Audi1orium and economically disadvantaged businesses, Welcome ro Macintosh 3/1 The deadline for submitting training and women-owned businesses. Advanced Macintosh Techniques 3/23 nominations is Mar. 27. Employees selected Whitted did not spend all her working years lnrro ro WordPerfect 3.0 2/13 will receive a confirmation letter. For more Intro 10 Microsoft Word 5.1 3/ 13 with che Disrrict and federal governments. information, call Mary Fisher, 2-3383. 0 Disaster Recovery & Data Security 3/7 She served as pare-time manager for Celebrity Intro 10 Lotus 1-2-3 Rel 2.4 2/13 Fashion Jewelry of New York City for 8 Excel 4.0 for Windows 2/21 years. Moreover, she has served on a number lnrro to Windows 3/8 Harvard Graphics 2.0 for Windows 2/24 of local and national boards such as the MS Word 6 .0 for Windows 2/7 Charlene D rew Jarvis Council for Women Intro ro Personal Computing for New Users 2/8 Business Owners; Nations Business League; minority business advisory board for Port Camera Club Meets, Feb. 14 America in Prince George's County; Black Business Alliance of Baltimore; Congressional The NIH R&W Camera Club meers Small Business Brain Trust; National Tuesday, Feb. 14 at 7:30 p.m. in Bldg. 31, Association of Black Procurement Profession­ Rm. 6C07. als; chair of the National Business League The guest speaker will be Dr. Jay Anderson, Council of Women Business Owners. She a retired pathologist currently operating also has served as first vice president of Blacks Anderson Fine Arc Photographs with his wife, in Government's NIH chapter. She is a 1983 Marilyn. He has been active in the photogra­ recipient of President Reagan's Award for phy field since che 1950's and his specialry is Outstanding Business Women; a member of digital imaging. During these years, he has Who's Who Among Black Americans in received numerous awards and participated in 1991, 1992, 1993; and recipient of the NIH many photographic exhibitions. He will give Director's Award in 1994. an overall review about digital imaging and Shirley Ann Sutphin, chiefof NICHD s Whirred is a producr of the D .C. school show some "progressive images" as examples. Adminfrtrative Management Branch, retired system, having attended Dunbar High Subjects for the meeting's competition are recently after 36years offederal service, of School, Catholic University, and the "lines, angles and curves." Formats include which 34 were spent at NIH. She joined NIH University of the District of Columbia. She B&W prints, novice and advanced levels; in March 1960 as a clerk-steno and was then has four sons, Allan Jr., Milan, Cedric, and color prints; and color slides, novice and promoted to secretary. In January 1981 she was Joseph; one daughter, Gwynetra; three advanced levels. offered a position as an administrative assistant daughters-in-law; a son-in-law and 14 The Camera Club is open to anyone and then 1 1/2 years later, she became an grandchildren. 0 interested in photography. While only administrative officer. In October 1987 she BIG Hosts History Lecture members may submit items for competition, was offered the position ofadministrative officer NIH's chapter of Blacks in Government newcomers are welcome ro attend meetings. in NICHD. Her motto for success is this: will host a Black History Month lecture on For more information, call Dr. Yuan Liu, vice "Hard work are the only words of wisdom that I Feb. 9 at l 1 :30 a.m. in Masur Auditorium, president, 6-8318. 0 can give. I believe that ifyou do a good days Bldg. 10. Dr. Keich Crawford ofNIDDK work every day, you will be rewarded. " will discuss ancient Egyptian civilization. 0 page 12

The Record January 31, I 995

User Resource Center Celebrates Decade of Computer Training, Support n 1985, a revolution was beginning at PC workstations for individual practice and INIH. Data processing was beginning to self-instruction. The cenrer's resource library URC Hosts Open House expand from large mainframe computers to provided access co a collection of sofrware The User Resource Center will be the desktops in NIH's offices and labs. This packages, training materials, books, and marking its 10th anniversary with an open was rhe result of the invention of the periodicals with a primary focus on office house on Thursday, Feb. 9 in the Bldg. 31 microcomputer, which quickly led to what applications. Direct assistance was available URC. All NIH staff are invited to stop by we know as the personal computer. NIH saw from DCRT lead users and other volunteer between 9 a.m. and noon to help celebrate. the benefits of rhis new way of data process­ NIH staff on rhe 2 days each week rhar the The User Resource Centers are open to ing, but was also faced with a challenge: center was open. all NIH staff, at no charge. The URC in How would NIH integrate these new During its first year, the URC provided Bldg. 31 is located in Rm. B2B47. Its technologies inro its operations co yield che support for BASIC, dBASE III, Display hours are 8:30 a.m.-7 p.m. Monday highest benefits-and how would the Write, Lotus, Symphony, Telios, and through Thursday, 8:30 a.m.-4:30 p.m. workforce gain the new skills and knowledge Personal Editor. Demonstrations were Friday, and 9 a.m.-1 p.m. Saturday. The required to take advantage of these new available on approximately 30 applications. Executive Plaza URC is located on the benefits? The center's hardware consisted of one IBM lower level of Executive Plaza South, 6120 It was at chis time that a small group of AT (80286), rwo IBM XTs, one Compaq, Executive Blvd. (Rm. T-10). Hours rhere NIH'ers came up with a bright idea: and one doc-matrix printer. There was one are 9 a.m.-4:30 p.m., Monday through classroom for hands-on training, equipped Thursday. with 11 XTs. During chat first year, the URC and its classroom logged more than 3,000 .employee contacts. Workstation Office (now the Distributed Things moved right along. In 1986, the Systems Branch) have continued through the software inventory included such programs as years to cooperate in making computer Multimate, WordStar, and Report Writer. resources available through the URC. Over By 1988, the hours had expanded co include these past 10 years there have been many 6 days a week and evenings. A full-rime staff changes in personal computer technologies had been established, including a director and and uses. Through all these changes, the a computer technician. In 1989 there were User Resource Center has continued irs seven workstations, including a Macintosh II. mission to assist NIH in efforts to bring these Laserjet printers were available, as well as a new technologies and their benefits inro rhe graphics plotter. WordPerfect had taken hold mainstream of NIH operations. D The URC opened its first facility in 1985. as rhe word processor of choice on the NIH campus. The URC's sofrware collection had integrate three critical areas of expertise­ grown to include 75 different packages, in Wednesday Afternoon Lectures personal computer systems, training and addition to 45 demonstration disks. Also in Continue in February development, and management analysis­ 1989, a second classroom was opened, with The Wednesday Afternoon Lectures needed to make rhe desktop computing borh PC and Macintosh workstations, continue in February with several talks sec for revolution a success at NIH. A walk-in making ir possible to conduct hands-on 3 p.m. in Masur Auditorium, Bldg. 10. facility could be created, in which NIH training in Macintosh applications. In 1993, On Feb. l, Dr. Joan S. Brugge, scientific employees would have easy access to rhe the URC opened a "branch" at Execmive director and senior vice pres.ident, research expertise and ralenr of staff from each of Plaza, providing hardware, software and and biology, Ariad Pharmaceuticals, Inc., in these areas. If that expertise were combined instruction to the growing NIH population Cambridge, Mass., will talk on "Regulation with examples of rhe latest technology, NIH on Executive Boulevard. of Tyrosine Phosphorylation by Integrin staffers could learn, use, and explore the Today it is difficult to imagine what the Receptors." Her lecrnre is sponsored by the capabilities presented to them by this URC must have been like during chose early NIH Postdoccora\ Fellows. technological cornucopia. days. In rhe world of informarion technol­ Two talks are planned for a special 3-5:30 So it was that, on Feb. 11 , l 985, the User ogy, things change on a daily basis-and so p.m. session on Feb. 8. Leading off is Dr. Resource Center (URC) opened its doors in does rhe URC. The XTs and ATs have long Anders Bjorklund, professor, department of Bldg. 31. The original program was a joint since been replaced by 386-based compmers, medical research, section of neurobiology, effort of the (then) Training Center, Division then 486s, Power Macs, and the recently U niversiry of Lund, Sweden, who will speak of Personnel Management; rhe Personal ordered Pentiums. CD-ROM drives, on "Neural Grafting in Parkinson's Disease." Workstation Office, DCRT; and the Records graphics scanners, and color printers are Next up is Dr. Mahlon Delong, Timmie Management Branch, Division of Manage­ among the innovations now considered professor and chairman, department of ment Policy. DCRT provided the computer standard to URC clients. Installed on the neurology, Emory University School of expertise and rhe funding, DPM provided Learning Labs' 16 computers in rwo locations Medicine, who will discuss, "Surgical the training expertise and the space, and are more than 100 PC applicarions and over Approaches to Parkinson's Disease." The DMP provided planning assistance and staff. 65 Macintosh applications. The original session is hosted by the Neurobiology Interest The center's mission was to provide a wide classroom is now equipped with 486 PCs, Group. range of automation and instruction services and three more classrooms have been added On Feb. 15, Dr. Dennis W. Choi, professor ro NIH employees, focusing on the adminis­ at Executive Plaza. Most recently, the URC and head of rhe department of neurology at trative use of personal compurers and has been installing and configuring a new Washington University School of Medicine, applications. Since that rime, rhe URC has Windows NTAS network in the classrooms will speak on "Rendering the Brain Resistant ass isted NIH in its ongoing journey into the and learning labs. The staff has expanded to to Stroke." His remarks are hosted by the world of personal computing, a journey char include a director, a coordinator, six com­ NIH Postdoctoral Fellows. would ultimately change the way offices puter specialists, and a network administra­ For more information about these lecrnres, work. cor. The Training Center (now the Division or about the series, contact Hilda Madine, 4- Ar its inception, rhe URC provided four of Workforce Development) and Personal 5595.