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Department of Health and Human Services National Institutes of Health
DEPARTMENT OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH RECOMBINANT DNA ADVISORY COMMITTEE MINUTES OF MEETING September 12-13, 1994 TABLE OF CONTENTS I. Call to Order/Dr. Walters II. Chair Report on Minor Modifications to NIH-Approved Human Gene Transfer Protocols/Dr. Walters III. Chair Report on Accelerated Review of Human Gene Transfer Protocols/Dr. Walters IV. Minutes of the June 9-10, 1994, Meeting V. Data Management Update/Dr. Smith VI. Discussion Regarding Criteria for RAC Review and Approval of Human Gene Transfer Protocols/Dr. Varmus VII. Addition to Appendix D of the NIH Guidelines Regarding a Human Gene Transfer Protocol Entitled: A Phase I Study of an Adeno-Associated Virus-CFTR Gene Vector in Adult CF Patients with MildLung Disease/Dr. Flotte VIII. Addition to Appendix D of the NIH Guidelines Regarding a Human Gene Transfer Protocol Entitled: Gene Therapy for the Treatment of Metastatic Breast Cancer by In Vivo Infection with Breast-Targeted Retroviral Vectors Expressing Antisense C-Fos or Antisense C-Myc RNA/Drs. Holt and Arteaga IX. Addition to Appendix D of the NIH Guidelines Regarding a HumanGene Transfer Protocol Entitled: Evaluation of Repeat Administrationof a Replication Deficient, Recombinant Adenovirus Containing the Normal Cystic Fibrosis Transmembrane Conductance Regulator cDNA to theAirways of Individuals with Cystic Fibrosis/Dr. Crystal X. Amendments to Sections I, III, IV, V, and Appendix M of theNIH Guidelines Regarding NIH and FDA Consolidated Review of Human Gene Transfer Protocols/Drs. Wivel and Noguchi XI. Addition to Appendix D of the NIH Guidelines Regarding a Human Gene Transfer Protocol Entitled: A Pilot Study of Autologous Human Interleukin-2 Gene Modified Tumor Cells in Patients with Refractory or Recurrent Metastatic Breast Cancer/Dr. -
Adenovirus Replication Is Coupltd E with the Dynamic Propernes of PML Nuclear Structure
Downloaded from genesdev.cshlp.org on October 5, 2021 - Published by Cold Spring Harbor Laboratory Press Adenovirus replication is coupltd e with the dynamic propernes of PML nuclear structure Vassilis Doucas, 1,s Alexander M. Ishov, 2 Anthony Romo, 1 Henry Juguilon, l'a Matthew D. Weitzman, 4 Ronald M. Evans, 1'3 and Gerd G. Maul 2 ~The Salk Institute for Biological Studies, La Jolla, California 92037; 2Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104; 3Howard Hughes Medical Institute, 4Institute for Human Gene Therapy, University of Pennsylvania, Philadelphia, Pennsylvania 19104 USA Wild-type PML and at least four other novel proteins are localized within discrete nuclear structures known as PODs. We demonstrate here that during adenovirus infection, immediate early viral proteins from the E1 and E4 transcription units associate with the POD, which in turn undergoes a dramatic morphological change. During this process, the auto-antigen Sp-100 and NDP55 but not PML, relocate from the POD to the viral inclusion bodies, the sites of adenovirus DNA replication and late RNA transcription. The E4-ORF3 11-kD protein alone will induce this reorganization and reciprocally, viruses carrying mutations in the E4-domain fail to do so. These same viral mutants are defective in viral replication as well as the accumulation of late viral mRNAs and host cell transcription shutoff. We show that interferon (INF) treatment enhances the expression of PML, reduces or blocks PODs reorganization, and inhibits BrdU incorporation into viral inclusion bodies. In addition, cell lines engineered to overexpress PML prevent PODs from viral-induced reorganization and block or severely delay adenovirns replication. -
U.S. DEPARTMENT of HEALTH and HUMAN SERVICES Public Health Service National Institutes of Health RECOMBINANT DNA ADVISORY COMMIT
U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Institutes of Health RECOMBINANT DNA ADVISORY COMMITTEE Minutes of Meeting -- March 1-2, 1993 TABLE OF CONTENTS I. Call to Order II. Minutes of March 1-2, 1993, Meeting III. Addition to Appendix D of the NIH Guidelines Regarding a Human Gene Therapy Protocol Entitled: Gene Therapy for the Treatment of Malignant Brain Tumors with In Vivo Tumor Transduction with the Herpes Simplex-Thymidine Kinase Gene/Ganciclovir System Drs. Culver and Van Gilder IV. Addition to Appendix D of the NIH Guidelines Regarding a Human Gene Therapy Protocol Entitled: Phase I Study of Gene Therapy for Breast Cancer Dr. Bank V. Addition to Appendix D of the NIH Guidelines Regarding a Human Gene Transfer Protocol Entitled: Administration of Neomycin Resistance Gene Marked EBV Specific Cytotoxic T Lymphocytes to Recipients of Mismatched-Related or Phenotypically Similar Unrelated Donor Marrow Grafts Drs. Heslop, Brenner, Rooney VI. Addition to Appendix D of the NIH Guidelines Regarding a Human Gene Transfer Protocol Entitled: Assessment of the Efficacy of Purging by Using Gene-Marked Autologous Marrow Transplantation for Children with Acute Myelogenous Leukemia in First Complete Remission Drs. Brenner, Krance, Heslop, Santana VII. Addition to Appendix D of the NIH Guidelines Regarding a Human Gene Therapy Protocol Entitled: A Phase I Trial of Human Gamma Interferon-Transduced Autologous Tumor Cells in Patients with Disseminated Malignant Melanoma Dr. Seigler VIII. Addition to Appendix D of the NIH Guidelines Regarding a Human Gene Therapy Protocol Entitled: Phase I Study of Non-Replicating Autologous Tumor Cell Injections Using Cells Prepared with or without Granulocyte- Macrophage Colony Stimulating Factor Gene Transduction in Patients with Metastatic Renal Cell Carcinoma Dr. -
Aidsepidemicinsf07chinrich.Pdf
University of California Berkeley Regional Oral History Office University of California The Bancroft Library Berkeley, California The San Francisco AIDS Oral History Series THE AIDS EPIDEMIC IN SAN FRANCISCO: THE MEDICAL RESPONSE 1981-1984 Volume VII Warren Winkelstein, Jr., M.D., M.P.H. AIDS EPIDEMIOLOGY AT THE SCHOOL OF PUBLIC HEALTH, UNIVERSITY OF CALIFORNIA, BERKELEY With an Introduction by James Chin, M.D., M.P.H. Interviews Conducted by Sally Smith. Hughes, Ph.D. in 1994 and 1995 Copyright 1999 by The Regents of the University of California Since 1954 the Regional Oral History Office has been interviewing leading participants in or well-placed witnesses to major events in the development of Northern California, the West, and the Nation. Oral history is a method of collecting historical information through tape-recorded interviews between a narrator with firsthand knowledge of historically significant events and a well- informed interviewer, with the goal of preserving substantive additions to the historical record. The tape recording is transcribed, lightly edited for continuity and clarity, and reviewed by the interviewee. The corrected manuscript is indexed, bound with photographs and illustrative materials, and placed in The Bancroft Library at the University of California, Berkeley, and in other research collections for scholarly use. Because it is primary material, oral history is not intended to present the final, verified, or complete narrative of events. It is a spoken account, offered by the interviewee in response to questioning, and as such it is reflective, partisan, deeply involved, and irreplaceable. ************************************ This manuscript is made available for research purposes. All literary rights in the manuscript, including the right to publish, are reserved to The Bancroft Library of the University of California, Berkeley. -
M.Sc Ist Yr MICROBIOLOGY a Bottle of Wine Contains More Philosophy Than All the Books in the World
M.Sc Ist yr MICROBIOLOGY A bottle of wine contains more philosophy than all the books in the world. -Louis Pasteur JANUARY 2022 M T W T F S S Ferdinand Cohn (Founder of 31 1 2 Bacteriology and Microbiology) Global Family Day 3 4 5 6 7 8 9 Richard Rebecca Har Michael Craighill Gobind Krause Lancefield Khorana Rebecca Craighill Lancefield (well known for serological classification of β- hemolytic streptococcal bacteria) 10 11 12 13 14 15 16 National Indian Youth Day Army Day 17 18 19 20 21 22 23 Bacillus cereus Bacillus cereus is a facultatively anaerobic, toxin producing, gram- positive bacteria that canm be found in siol vegetation anf even food. This may cause two types of intestinal illness, one diarrheal, and 24 25 26 27 28 29 30 one causing nausea and vomiting.It Ferdinand National Heinrich World can quickly multiply at room Kohn Tourism Anton de Leprosy temperature. B.cereus has also been National Girl Day Bary Day Child Day Republic implicated in infections of the eye, respiratory tracts , and in wounds. International Day B.cereus and other members of Day of Education bacillus are not easily killed by alcohol,they have been known to World Leprosy Day – 30th JAUNARY: World Leprosy colonize distilled liquors and Day is observed internationally every year on the last Sunday of alcohol soaked swabs and pads in January to increase the public awareness of leprosy or Hansen's numbers sufficient to cause Disease. This date was chosen by French humanitarian Raoul infection. Follereau as a tribute to the life of Mahatma Gandhi who had compassion for people afflicted with leprosy. -
Emerging Viruses: the Evolution of Viruses and Viral Diseases Author(S): Stephen S
Emerging Viruses: The Evolution of Viruses and Viral Diseases Author(s): Stephen S. Morse and Ann Schluederberg Source: The Journal of Infectious Diseases, Vol. 162, No. 1 (Jul., 1990), pp. 1-7 Published by: Oxford University Press Stable URL: http://www.jstor.org/stable/30127833 Accessed: 18-08-2014 21:02 UTC Your use of the JSTOR archive indicates your acceptance of the Terms & Conditions of Use, available at http://www.jstor.org/page/info/about/policies/terms.jsp JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact [email protected]. Oxford University Press is collaborating with JSTOR to digitize, preserve and extend access to The Journal of Infectious Diseases. http://www.jstor.org This content downloaded from 155.58.212.160 on Mon, 18 Aug 2014 21:02:31 UTC All use subject to JSTOR Terms and Conditions 1 Fromthe NationalInstitute of Allergy and Infectious Diseases, the FogartyInternational Center of the National Institutesof Health, and the RockefellerUniversity Emerging Viruses: The Evolution of Viruses and Viral Diseases Stephen S. Morse and Ann Schluederberg From the Rockefeller University,New York,New York,and the National Institute of Allergy and InfectiousDiseases, National Institutesof Health, Bethesda, Maryland Challengedby the sudden appearanceof AIDS as a major rus and host can follow severalpossible lines, and pathogens public healthcrisis, the National Instituteof Allergy and In- may not always evolve towardslower virulence. -
Harold S. Ginsberg 1917–2003
Harold S. Ginsberg 1917–2003 A Biographical Memoir by Arnold J. Levine ©2014 National Academy of Sciences. Any opinions expressed in this memoir are those of the author and do not necessarily reflect the views of the National Academy of Sciences. HAROLD SAMUEL GINSBERG May 27, 1917–February 2, 2003 Elected to the NAS, 1982 Harry Ginsberg was one of the founders of modern virology. He began his career with research in epidemi- ology, describing the pathogenesis of viral infections, the course of infections, and their outcomes. This was followed by the isolation of novel viruses. Harry was associated with the identification of several adenovirus serotypes that caused acute respiratory diseases, atypical pneumonia, and respiratory illnesses common to children. His lifelong study of the adenoviruses made this group of viruses one of the most intensively explored and better understood classes of viruses. Having identified the adenoviruses and their pathogenic consequences, Harry changed his research direction, By Arnold J. Levine helping to create the field of the molecular biology of animal viruses. His research uncovered each of the phases of viral replication, and he was among the first to apply chemotherapy to interrupt virus replication and prevent pathogenesis. In addition, he studied how a virus could inhibit the synthesis of cellular RNA and proteins and how viruses redirected cellular metabolism for the propagation of these agents. H e then changed his research direction for a third time, employing molecular genetics to uncover the functions of adenovirus genes and their regulation. As it became clear that some adenovirus serotypes could cause cancers in animals, Harry’s research group prepared the antiserum from tumor-bearing animals to unravel the viral tumor antigens. -
Genealogy and Diversification of the AIDS Virus
I Diversification of the AIDS Virus Gerald L. Myers, C. Randal Limier, and Kersti A. MacInnes T disease, caught the world by surprise—so much so that the virus that causes AIDS (the human immunodeficiency virus, or HIV) was suspected by some of being an instrument of biological warfare or an accident of genetic engineering. HIV is now almost universally accepted as no more than another creation of evolution, but defini- tive information about its evolutionary past, present, and future is still lacking. What was the more benign or more confined progen- itor of HIV? What is its relationship to other viruses with similar physical or pathological properties? How rapidly do variations of HIV evolve? What more pernicious forms might yet appear? 41 Genealogy of the AIDS Virus EVOLUTIONARY RELATIONSHIPS AMONG RETROVIRUSES Equine Infectious Anemia Virus Caprine Arthritis Encephalitis Virus Such questions are being addressed Lentiviruses by analyzing the characteristics of HIV at the molecular level, as the following Visna example illustrates. HIV is a retrovirus Virus and as such has a genome composed of RNA rather than DNA (see “Viruses and Their Lifestyles”). The first step Human in the replication of a retrovirus is syn- immuno- thesis of DNA from the RNA template deficiency Virus provided by the viral genome. That synthesis is catalyzed by enzymes— reverse transcriptases—that are virtually unique to retroviruses. Likely evolution- Simian ary relationships among HIV and other Retrovirus disease-causing retroviruses have been deduced from the differences among the sequences of amino acids that compose their reverse transcriptases. The same has also been done for retroviruses by focusing on their proteases, enzymes Virus common to all organisms and essential Oncoviruses to the breakdown of other proteins. -
Commencement 1961-1970
mri mm si* THE JOHNS HOPKINS UNIVERSITY BALTIMORE, MARYLAND Conferring of Degrees at the close of the ninety-second academic year JUNE 11, 1968 Keyser Quadrangle Homewood • O • to S • to 2 • 2 P-. co >• S co S *0 • •> • (0 «, •>••»•> C co co ^ •> *0 0)^3 0) 0) C'HrHOCO H fcQSrHtO•rHW OftO XJ En •HCSH£ -P • <D g .H£ H *-P to S <H •H«fc>0«*©CDH«H bfl CO Md Ba At E-< Bait Green Sprin lewood indsor Philad ahasse § imore, Chevy of of b f ng, O o of W of Map of Spri of Tall Bait ter, a k, , of Jr., , O «rt X •» •» CM s OOOXk •> Jh «H »(1)<HH 1 H O-P<pC0fDOfc£OH ID NJ3 EH OP iH 3 * U < H O-pJC-H fc, H rH rH P« ,* CD pa «H-HOCOkI©HS ox ^ * £& & . S MC oo o >> CO EC SC <H UJ XSSOH.3 EH Po 8* Mit Bradl Franc Harve Randal Henry Ernest utchin ugene I Jones Lord, le ohn H W CO ppTi to tC >-D tu j) (Dpi: ^a-o h tO T3 bDH ^ -P CO rH CO CO CD .GOt>Oc0Xl6OC0^£gH«H k 5* CD O .C C O 0) Q) +J ajto<i)x:o-H-Hr-!rotOc3cfl ORDER OF PROCESSION The Graduates Marshals Peter Achinstein Richard A. Macksey Carl Christ Evangelos Moudrianakis Robert E. Green, Jr. John H. Mulholland John W. Gryder Owen M. Phillips Edgar A. J. Johnson William Poole Everett L. Schiller * The Faculties Marshals James Deese and John Walton * The Deans, The Vice Presidents, The Trustees, and Honored Guests Marshals Ferdinand Hamburger and Alsoph H. -
Back Matter (PDF)
Reviewers, Volume 4* (1990) The Editors would like to thank the Coffin, John Gottesman, Susan Editorial Board and the following Cole, Michael Gralla, Jay scientists who were kind enough to Copeland, Neil Graves, Barbara review papers and provide advice during Costantini, Frank Green, Howard 1990. Your help has been invaluable Cozzarelli, Nicholas Green, Michael and is greatly appreciated. Crabtree, Gerald Greenberg, Michael Craig, Elizabeth Greenblatt, Jack *From November 1, 1989 to November Cross, Fred Greene, Warner 15, 1990 Cullen, Bryan R. Greenstein, Michael Curran, Tom Greenwald, Ira Aaronson, Stuart Davidson, D. Greider, Carol Abelson, John Davidson, Eric Grindley, Nigel Acheson, Nicholas Davis, Mark Gross, Carol Adhya, Sankar DePamphilis, Melvin L. Grosschedl, Rudi Aloni, Y. Desplan, Claude Groudine, Mark Alt, Fred Deutsche:, Murray Gruss, Peter Anderson, Phil Devreotes, Peter Gurdon, John Martinez Arias, Alfonso Dexter, M. Guthrie, Christine Arndt, Kim Di Maio, Dan Hamlin, Joyce Artavanis-Tsakonas, Spyros DiNardo, Stephen Hanafusa, Hidesaburo Ausubel, Frederick Dreyfuss, Gideon Hansen, Ulla Harland, Richard Baker, Bruce Duboule, Denis Hauscka, Steve Baltimore, David Dunaway, Marietta Hayward, Gary Bard, J. Dynan, William Hearing, Patrick Bautch, Victoria Earnshaw, William Heintz, Nat Beach, David Echols, Harrison Helfman, David Bedinger, P. Ehrenfeld, Ellie Hernandez, Nouria Belasco, foel Eichele, Gregor Hershey, John Bentley, D. Eicher, Eva Herskowitz, Ira Berk, Arnold Eisenman, Robert Higgins, C. Bernstein, Alan Elgin, Sarah Hirmebusch, Allan Bert, Arnold Emerson, Charles Hirsh, Jay Bevan, Michael Engel, Douglas Hopkins, Nancy Biggin, Mark Evans, Ron Horowitz, Ira Bingham, Paul Fan, Hung Howard, Ken Bird, Adrian Federoff, Nina Howley, Peter Bishop, Michael Fields, Stanley Huen, D. Blackburn, Elizabeth Finnegan, D. Hughes, Steve Blau, Helen Finney, Mike Hunt, Tim Bogenhagen, Daniel Firtel, Richard Hunter, Tony Borst, Piet Frendewey, David Ingham, Phillip Bothwell, Al Freundlich, Marty Jackson, I. -
January 31, 1995, NIH Record, Vol. XLVII, No. 3
January 31, 1995 Vol. XLVll No. 3 "Still U.S. Department of Health The Second and Human Services Best Thing About Payday" National Institutes of Health IH Recori Performing a 'Grace Note' OE's 'Saturday School' King Program Stresses 'Everyone Can Serve' Reaps Prompt Rewards By Carla Garnett By Ruth Levy Guyer ,C, and R may be, after N, I, and H, he high temperature on Friday, Jan. 13 was 68 degrees. In Masur Auditorium, che Pthe three letters most often juxtaposed NIH director recalled his I 960 procesc march, a surgeon miked jazz, children made in conversations on the NIH campus. So one T rainbows, and in between, all the traditional trappings-the posting of the colors, the would not normally label a discussion of reading of rhe litany, and entertainment by talented musicians-of an NIH Marcin Lurher PCR basics and the merits of che technology King, Jr. Commemoration were observed as well. "remarkable." But remarkable is an ape term Adopting the theme, "Everyone Can Serve; Help Somebody," rhe celebration sponsored by for a recent session in the Cloister, because NIH's Office of Equal Opportunity actually began weeks earlier when recepracles for donations che discussanrs were teenagers. of canned goods and ocher items to be disrribuced co area homeless shelters were placed in NIH The 25 students comfortably batting facilities. Program coordinaror O.H. Laster of OEO said an estimated "30 million Americans around words like polymerases, chermocy nightly go co bed hungry in che so-called cling, and restriction enzymes were summing land of plenty." Srariscics such as those, he (See SATURDAYS, Page 6} continued, prompted the humanitarian theme for this King commemoration. -
The AZT Story
POISON BY PRESCRIPTION The AZT Story By John Lauritsen Foreword by Peter Duesberg ASKLEPIOS York New1990 POISON BY PRESCRIPTION: The AZT Story by John Lauritsen Foreword by Peter Duesberg Published by ASKLEPIOS/Pagan Press. Copyright c 1990/1992 by John Lauritsen All rights reserved. Printed in the USA. Fourth Printing: November 1992 Correspondence regarding this book should be directed to: John Lauritsen, 26 St. Mark's Place, New York City 10003. John Lauritsen's new book, The AIDS War, will be published by Asklepios early in 1993. If not available in a convenient bookstore, POISON BY PRESCRIPTION can be ordered for $12 (postpaid) from the author at the above address. Library of Congress Catalog Card No. 90-81328 ISBN 0-943742-06-4 Dedicated to the" AIDS Dissidents"- who dared to speak out during an epidemic of lies: jad Adams Walter Gilbert Charles Ortleb Hansueli Cliff Goodman Neenyah Ostrom Albonico Beverly Griffin Gerard Pollender Max Allen Group for the Positively Healthy Laurence Badgley Scientific Projektgruppe Michael Reappraisal of AIDS-Kritik, Baumgartner the HIV-AIDS Gesamtdeutsche Harvey Bialy Hypothesis Initiative Edward Brecher H.E.A.L. jon Rappaport Tony Brown john Hammond Nick Regush Frank Albert Hassig Robert Root- Buianouckas Nicky Hirsch Bernstein Allan Burns Neville Harry Rubin Michael Callen Hodgkinson S.A.A.O. Mike Chapelle Robert Hoffman (Netherlands) Richard and Bill and Claudia Ruth Sackman Rosalind Holub Casper Schmidt Chirimuuta Drew Hopkins Peter Schmidt Seymour Cohen Guido Horner Kawi Schneider Andrew Cort