Reviewers, Volume 4* (1990)

The Editors would like to thank the Coffin, John Gottesman, Susan Editorial Board and the following Cole, Michael Gralla, Jay scientists who were kind enough to Copeland, Neil Graves, Barbara review papers and provide advice during Costantini, Frank Green, Howard 1990. Your help has been invaluable Cozzarelli, Nicholas Green, Michael and is greatly appreciated. Crabtree, Gerald Greenberg, Michael Craig, Elizabeth Greenblatt, Jack *From November 1, 1989 to November Cross, Fred Greene, Warner 15, 1990 Cullen, Bryan R. Greenstein, Michael Curran, Tom Greenwald, Ira Aaronson, Stuart Davidson, D. Greider, Carol Abelson, John Davidson, Eric Grindley, Nigel Acheson, Nicholas Davis, Mark Gross, Carol Adhya, Sankar DePamphilis, Melvin L. Grosschedl, Rudi Aloni, Y. Desplan, Claude Groudine, Mark Alt, Fred Deutsche:, Murray Gruss, Peter Anderson, Phil Devreotes, Peter Gurdon, John Martinez Arias, Alfonso Dexter, M. Guthrie, Christine Arndt, Kim Di Maio, Dan Hamlin, Joyce Artavanis-Tsakonas, Spyros DiNardo, Stephen Hanafusa, Hidesaburo Ausubel, Frederick Dreyfuss, Gideon Hansen, Ulla Harland, Richard Baker, Bruce Duboule, Denis Hauscka, Steve Baltimore, David Dunaway, Marietta Hayward, Gary Bard, J. Dynan, William Hearing, Patrick Bautch, Victoria Earnshaw, William Heintz, Nat Beach, David Echols, Harrison Helfman, David Bedinger, P. Ehrenfeld, Ellie Hernandez, Nouria Belasco, foel Eichele, Gregor Hershey, John Bentley, D. Eicher, Eva Herskowitz, Ira Berk, Arnold Eisenman, Robert Higgins, C. Bernstein, Alan Elgin, Sarah Hirmebusch, Allan Bert, Arnold Emerson, Charles Hirsh, Jay Bevan, Michael Engel, Douglas Hopkins, Nancy Biggin, Mark Evans, Ron Horowitz, Ira Bingham, Paul Fan, Hung Howard, Ken Bird, Adrian Federoff, Nina Howley, Peter Bishop, Michael Fields, Stanley Huen, D. Blackburn, Elizabeth Finnegan, D. Hughes, Steve Blau, Helen Finney, Mike Hunt, Tim Bogenhagen, Daniel Firtel, Richard Hunter, Tony Borst, Piet Frendewey, David Ingham, Phillip Bothwell, Al Freundlich, Marty Jackson, I. Brandhorst, Bruce Friedman, David Jan, Yuh-Nung Brawerman, George Fristrom, James Johnson, Alexander Britt, Anne Fuchs, Elaine Johnson, Peter Broach, James Futcher, Bruce Joho, Keith Brockes, J. Fyrberg, Eric Jolicouer, Paul Brown, Donald Gallimore, Phil Jones, Katherine Buchman, Andrew Ganem, Don Joyner, Alex Burhans, William Garber, Richard Kadesch, Tom Burr, Ben Gaynor, Richard Kadonaga, James Calame, Kathryn Gehring, Walter Kaiser, Dale Calendar, Richard Geiduschek, E.P. Kao, C. Cheng Carlson, Mary Ann Gelbart, William Karan, James Carroll, Sean Gellert, Martin Karin, Michael Cepko, Connie Georgeopoulos, Constantine Kam, J. Chalfie, Martin Gergen, Peter Chater, Keith Gerisch, Gunter Kedinger, Claude Childs, Geoff Gilman, Mike Keller, Walter Chory, Joanne Glover, David Kelly Tom Clayton, David Gold, Larry Kessin, Richard Clements, J.B. Gonzalez, F. Kieff, Elliot Cleveland, Donald Goodman, Corey Kingston, Robert Coen, Enrico Gordon, C. Kirschner, M.

GENES & DEVELOPMENT 2409 Kleckner, Nancy Nevins, Joseph Smith, Alan Klessig, Daniel Newton, Austin Smith, J. Klobutcher, Larry Nienhuis, Arthur Somerville, Christopher Knowles, Barbara Nurse, Paul Sonenberg, Nahum Kolodner, Richard O'Hare, Peter Spradling, Allan Komberg, Roger Odenwald, Ward Sprague, George Komberg, Thomas Olson, Eric Stamatov-Annopoulous, G. Kouzarides, T. Osley, Mary Ann Stanley, Pamela Krainer, Adrian Parada, Luis Stark, George Krasnow, Mark Pardue, Mary Lou Steitz, Joan Krumlauf, Robb Parker, Malcolm Stellar, Herman Kucherlapati, Radu Paule, Marvin Stenlund, Arne Laithe, R. Peebles, Craig Sternglanz, Rolf Lamb, Christopher J. Pelham, Hugh Stevenin, F.J. Lambowitz, Alan Peterlin, Matija Steward, Ruth Lamond, A. Piatt, Terry Stiles, Chuck Landy, Arthur Postlethwait, J. Stillman, Bruce Lane, David Prives, Carol Strickland, Sidney Lawrence, Peter Proudfoot, Nicholas J Struhl, Gary Lehman, Ruth Raff, E.G. Struhl, Kevin Lengyel, Peter Ransone, Lynn Surani, M. Azim Levin, Joshua Ready, Donald Szostak, Jack Levine, Amold Reed, Steve Tatchell, Kelly Levine, Michael Reeder, Ronald H. Tegtmeyer, Peter Levy, Michael Reik, W. Thorner, Jeremy Ley Timothy Rice, Andrew Thummel, Carl Lilley, D. Rigby, Peter Tilly, Kit Rio, Don Lindahl, Lasse Timberlake, William E. Risser, Rex Linney, Elwood Tonegawa, Susumu Roberts, Jeff Lonssdale, Townes, Timothy Robertson, Liz Loomis, Bill Travers, A.A. Roeder, Robert Losick, Richard Treizenberg, Steve Rosbash, Michael Lovell-Badge, Robin Ullrich, Axel Rosenberg, Naomi Luktenhaus, Joe Ullu, Elizabetta Rosenfeld, M, Geoff Lund, Elsabet Vassalli, J.D., Rossant, Janet MacDonald, Paul Verma, Inder Rubin, Gerry MacDonald, Ray Wahl, Geoffrey Ruvkun, Gary Mak, Tak Warner, Jonathan R. Sachs, Alan Maniatis, Tom Wasylyk, C. Saedler, H. Martienssen, Rob Weatherall, D. Sapienza, Carmen Martin, Gail Weinberg, Robert Sassone-Corsi, Paolo Marzluff, William F. Weiner, Alan Schaap, Pauline Matrisian, Lynn Weintraub, Harold M. Schedl, Paul Matton, D. Wensink, Pieter Schibler, Ueli McClure, William Werb, Zina Schpbach, Trudi McCormick, Shelia Westphal, Henry Schutz, G. McGhee, James Wickens, Marvin Segraves, William McKeown, Michael Wickner, Sue Setlow, Peter McMahon, Andrew Wieschaus, Eric Sharp, Phillip Melton, Douglas Wigler, Mike Shenk, Thomas Meyer, Barbara Wilkinson, D. Sherr, Charles Meyerowitz, Elliott Williams, Jeff Sherratt, David Moore, Claire Willison, Keith Shimkets, L. Moran, Betty Winston, Fred Shulman, LaDonne Morimoto, Richard Wolgemuth, Deborah Shur, Barry Mount, Steve Wright, Christopher Silhavy, Tom Mller, Martin Yamamoto, Keith Simons, Robert Muller, R. Yaniv, Moshe Sippel, E. Nabel, Gary Young, Michael Nadal-Ginard, Bernardo Young, Richard Skowronski, Jacek Neidhardt, F. Ziff, Edward Slack, Jonathan Nemer, Martin Zipursky, Lawrence

2410 GENES & DEVELOPMENT Advertisers, Volume 4

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GENES & DEVELOPMENT 2411 Author Index, Volume 4 (1990)

Abelson, J., 1185 Bottomly, K., 1304 De Robertis, E.M., 1910 Fuchs, E., 1985 Abmayr, S.M., 2086 Boulukos, K.E., 401 Decker, G., Ill Gallic, D.R., 1149 Abrams, L., 835 Brady, C, 390 Deininger, P.L., 2333 Ganem, D., 764 Adhya, S., 410 Brandhorst, B.P., 111 Dellmg, U., 1365 Gavin, B.J., 2319 Admon, A., 822, 1741 Breitenbach, M., 1775 Descombes, P., 1541 Gehring, W.J., 1224 Affolter, M., 1224 Brennan, T.J., 582 Diederich, R.J., 2188 Gelbart, W.M., 1114 Agabian, N., 2121 Brice, M., 1637 Dillon, P.J., 1357 Gergen, J.P., 1701 Ahmed, Y.F, 1014 Bnll, S.J., 968 Din, S.-u., 968 Ghysdael, J., 401, 1663 Ahn, M.-H, 1611 Brinster, R.L., 380 Dohrmann, C, 2098 Giddens, E., 390 Albert, V.R, 43 Britten, R.J., 1999 Dolan, J.W., 492 Giglio, L.M., 2146 Alessi, D., 2210 Briza, P., 1775 Draper, B.W., 932 Giroud, C, 1374 Ali, Z, 1079 Broide, R.S., 695 Driscoll, M.C., 1637 Gizang-Ginsberg, E., 477 Ammerer, G., 299 Brow, D.A., 1345 Dubnau, D., 860 Glineur, C, 1663 Antoniou, M., 1007 Brown, B.D., 1925 Dubnau, E., 860 Gober, J.W., 1494 Apelian, D., 1396 Brown, D.D., 1107, 1602, 1917 Duffy, J.B., 1701 Gold, L., 1790 Ares, Jr., M., 2132 Brown, J.L., 624 Duncan, 1., 1936 Golemis, E., 233 Arias, A.M., 2086 Bryner, R.S., 667 Dutta, A., 243 Goodman, C.S., 2169 Artavanis-Tsakonas, S., 464, 2169, 21^ Buchman, A.R., 503 Eaton, S., 1068 Goodstein, M., 1999 Ashbumer, M., 905 Burgess, R.R,, 2048 Echols, H., 410 Gottesman, S., 2036 Ayyub, H., 1588 Busslinger, M., 849 Edwards, C.A., 372 Grabowski, P.J., 1172 Azpiazu, N., 2098 Calame, K., 1404 Edwards, D.R., 2308 Graves, B.J., 667, 1451 Baeuerle, P.A., 1975 Calzone, F.J., 1999 Edwards, K.A., 885 Graves, M.K., 372 Bailly, M., 401 Camerini-Otero, C.S., 1951 Eichele, G., 1267 Green, M.R., 2376 Baker, B.S., 89, 789 Camerini-Otero, R.D., 1951 Eichinger, D.J., 324 Greenberg, M.E., 255 Baker, N.E., 1848 Campbell, P.L., 1252 Eisen, R, 1374 Greene, W.C, 1014, 1875 Ball, Jr., A.R., 1677 Capaci, T.M., 1516 Eisenman, R.N., 2025, 2235 Gregor, P.D., 1730 Baltz, T., 1374 Carcamo, J., 1611 Eldon, E.D., 111 Grimaila, R., 1114 Banroques, J., 1185 Carding, S.R., 1304 Elledge, S.J., 157, 740 Gross, C.A., 2202 Barbacid, M., 683 Carlson, L.M., 536 Ellinger, A., 1775 Grosveld, F., 1007, 2075 Barberis, A., 849 Carpenter, R., 1483 Ellisman, M.H., 806 Groudine, M., 75, 1637 Barkan, A., 331 Carpousis, A.J., 873 Elsholtz, H.P., 43 Guarente, L., 1714 Emerson, Jr., C.P., 567 Barras, E., 1528 Celada, A., 1451 Gunderson, S.I., 2048 Engle, J.D., 1650 Easier, K., 728 Chambon, P., 137 Gunther, C.V., 667, 1451 Chan, K., 63 Enver, T., 1637 Bate, M., 2086 Guthrie, C, 1185, 1345, 2264 Chang., C.H.W., 1677 Epner, E., 1637 Ha, I., 1611 Baumhueter, S., 372 Chaplin, D., 978. Errede, B., 1862 Haasch, D., 978 Beach, D., 9 Chapman, A.L., 18 Evans, M.J., 1023 Haber, R., 410 Beckmann, H., 167 Chasman, D.I., 503 Fairman, M.P., 968 Fiaberstroh, L., 596 Bednarz, A.L., 2366 Chen, C.-H., 1365 Falvey, E., 1541 Hafen, E., 728 Behringer, R.R., 380 Cho, K.W.Y., 1910 Fan, C.-M., 29 Hagman, J., 978 Bell, S.P., 943 Chojkier, M., 1541 Fey, S., 1528 Hake, L.E., 63 Benchimol, S., 1 Chua, N.-H., 1899 Fields, S. 492 Hama, C, 1079 Bender, W., 1573 Cianetti, L., 180 Fiering, S., 1823 Hanafusa, H., 243 Benzer, S., 806 Clark, CD., 2252 Finkelstein, R., 1516 Hanly, S.M., 1014 Berg, P., 157 Cochrane, A.W., 1357 Finn, L.A., 98 Hansen, U., 287 Berget, S.M., 1552 Coen, E.S., 1483 Firtel, R.A., 18, 419, 596 Harland, R.M., 932, 1925 Berk, A.J., 151 Collier, V.L., 885 Fleming, R.J., 464,2188 Hart, A.C, 1835 Bernstein, A., 390 Conboy, M.J., 1128 Flenniken, A.M., 1094 Hartley, J.W., 233 Bernstein, S.I., 885 Conley, P.B., 372 Flint, J., 1611 Hartshome, T., 2121 Berte, C, 1528 Connell, L., 1862 Fodor, E., 1035 Hartz, D., 1790 Bettler, D., 1688 Conway, G.C., 1158 Forrester, L., 390 Hausner, T.-P., 2146 Beug, H., 1650, 1663 Corces, V.G., 1505 Forrester, W.C, 1637 Hayday, A.C, 1304 Bier, E., 190 Cortes, P., 1611 Fortini, M.E., 444 Hayward, W.S., 75 Binkley, J., 1790 Costa, R.H., 1427 Fox, C.A., 2287 Heath, J.K., 2308 Blackman, R.K., 1114 Courtois, C, 372 Frasch, M., 2098 Heberlein, U., 712 Blochlinger, K., 1322 Crabtree, G.R., 372, 1823 Fredrickson, T.N., 233 Helfman, D.M., 98 Bodmer, R., 1322 Craven, M.G., 2210 Freeling, M., 331 Hennessy, K.M., 2252 Boeke, J.D., 324 Cullen, B.R., 1014 Freimuth, P., 1197 Hernandez, N., 2061 Bonner, A.S., 1701 Dale, M., 2157 Fridell, R.A., 559 Herrero-Sanchez, C, 1528 Boocock, M.R., 2366 Darby, M.K., 1602 Friedel, C, 1688 Herzenberg, L.A., 1823 Bordonn, R., 1185, 2264 Darnell, J.E., Jr., 1427, 2353 Friedman, A.D., 1416 Higgs, D.R., 1588 Bos, T.J., 1677 Davidson, E.H., 1999 Friedman, D.I., 2210 Hirai, H., 2342 Boshart, M., 1437 Davis, R.W., 157, 740 Fromental, C, 137 Hjorth, A.L., 419 Botchan, M.R., 123 de Bisschop, N., 955 Fu, X.-Y., 1753 Ho, W.Y.-W., 1197 Botstein, D., 2252

2412 GENES & DEVELOPMENT Hoffmann, A., 1141 Komberg, T.B., 1068, 1079 Martm, D.I.K., 1886 Palmer, M.J., 789 Hoffmann, F.M., 1114, 2011 Kovelman, R., 646 Martm, K.J., 2376 Palmiter, R.D., 380 Hoffmann, H.M., 1172 Kozak, D., 1158 Martin-Zanca, D., 683 Papayannopoulou, T., 1637 Hogness, D.S., 204 Krainer, A.R., 1158 Masucci, J.D., 2011 Pape, L.K., 52 Hollingsworth, T., 1790 Krmer, H., 1835 Mathews, M.B., 2397 Parada, L.F., 683 Holloway, J.M., 695 Krasnow, M.A., 1044 Mattila, P.S., 1823 Parsell, D.A., 277 Holmgren, R.A., 1053 Kretzner, L., 1766 Mattox, W., 789 Patel, N., 822 Hopkins, N., 233 Krinke, L., 2223 Mattson, D.M., 1936 Pears, C., 419 Horikoshi, M., 1141, 1899 Kris, R.M., 955 McCormack, W.T., 536, 548 Peifer, M., 1209 Horvitz, H.R., 357 Krisch, H.M., 873 McDonagh, K.T., 993 Penchev, R., 860 Howard, G., 1316 Kristie, T.M., 2383 McKearm, D.M., 2242 Perkins, K.K., 822 Hsieh, P., 1951 KrolJ, K.L., 1053 McKercher, S.R., 1451 Perrimon, N., 1516 Hu, Y.-F., 1741 Kronert, W.A., 885 McKnight, S.L., 1416 Peschle, C, 180 Huang, H.-C, 287 Kronstad, J.W., 1384 McMahon, A.P., 2319 Pfeifer, G.P., 1277 Hughes, S.H., 1462 Kukowska-Latallo, J.F., 1288 McMahon, J.A., 2319 Pick, L., 1224 Humphries, E.H., 536 Kulesh, D., 835 McStay, B., 1240 Platero, J.S., 1404 Hunt, T., 2157 Kulozik, A., 1252 Meijer, L., 9 Pognonec, P., 401 Igel, A.H., 2132 Kunkel, B., 525 Meisler, M.H., 1316 Pollock, J.A., 806 Ingraham, H.A., 695 Kuo, C.J., 372 Meister, A., 1035 Pondaven, P., 9 Inouye, S., 1396 Kuo, H.-c, 1172 Mendel, D.B., 372 Porter, J., 2333 Irick, H.A., 1114 Kyes, S., 1304 Mercola, M., 2333 Postema, C.E., 536 Iwasaki, K., 2299 La Brousse, F.C., 567 Mermod, N., 1741 Pret, A.-M., 559 Jackson, S.P., 659 Labhart, P., 269 Michel, F., 777 Pretorius, I.-M., 1588 Jacobs, J.R., 2169 Lagrou, C, 401 Michelson, A.M., 2086 Prezioso, V.R., 1427 Jacques, J.-P., 1801 Lai, E., 1427, 2353 Miltenberger, R.J., 2011 Prywes, R., 955 Jan, L.Y., 190, 1322 Lam, L., 1688 Mitsunobu, F., 1677 Rathjen, P.D., 2308 Jan, Y.N., 190, 1322 Mlodzik, M., 1848 Landick, R., 1623 Ratnasabapathy, R., 2061 Jang, S.K., 1560 Monteclaro, F.S., 1677 Lane, D.P., 1 Rebay, I., 464 Jantzen, H.-M., 943 Montpetit, I.C, 111 LaPointe, J.W., 503 Reed, S.I., 1332 Jarman, A.P., 1588 Mooney, J.L., 1473 Larsen, R.D., 1288 Reeder, R.H., 269, 1240 Jasin, M., 157 Moran, L., 752 Lasko, P.F., 905 Reinberg, D., 1611 Jenkinson, E.J., 1304 Morham, S.G., 515 Laspia, M.F., 2397 Reith, A.D., 390 Johal, L., 2061 Mudd, E.A., 873 Lau, Y.-F.C, 63 Reith, W., 1528 Johnson, F.B., 1044 Mulligan, G.J., 98 Leask, A., 1985 Renjifo, B., 233 Johnson, L.L., 2210 Nagamine, C.M., 63 Lee, D.N., 1623 Rhodes, N., 1862 Johnson, T.M., 1316 Nagoshi, R.N., 89 Lemischka, I.R., 220 Rice, A.P., 2397 Joho, K.E., 1602 Nair, R.P., 1288 Leonard, M.W., 1650 Richardson, H.E., 1332 Jones, R.W, 1252 Nairn, CM., 1357 Leong, S.A., 1384 Riggs, A.D., 1277 Jordan, C.T., 220 Nasim, F.-u.H., 1172 Rivera, V.M., 255 Kadesch, T, 167 Lepesant, J.-A., 922 Nelson, C., 1035 Rochette-Egly, C., 137 Kafatos, F.C., 1128 LeSrange, R.C., 75 Netter, P., 777 Roeder, R.G., 646, 1141, 1730, 1899 Kaiser, D., 896 Levy, D.E., 1753 Ney, P.A., 993 Kal, A.J., 1964 Liao, S.-M., 313 Nguyen, T., Ill Roman, C., 1404 Kania, M.A., 1701 Liao, X., 1766 Nguyen-Huu, M.C., 180 Rosbash, M., 1766 Karch, F., 1573 Lichtsteiner, S., 1541 Nichols, J., 2308 Roscigno, R.F., 98 Karim, F.D., 1451 Lida, J., 1588 Nienhuis, A.W., 993 Rose, S.D., 1552 Kasai, Y., 1611 Lillie, J.W., 2376 Nishimura, T., 1677 Rosen, C.A., 1357, 1365 Kassis, J.A., 433 Lindenbaum, M.H., 2075 Nitsch, D., 1437 Rosenberg, M., 1985 Katagiri, F., 1899 Litvin, O., 1427 Niwa, M., 1552 Rosenberg, M.P., 1316 Kedes., L., 1811 Logan, S.K., 613 Nolan, G.P., 1823 Rosenfeld, M.G., 43, 695 Keller, S.A., 1316 Lorch, Y., 503 Norris, D., 752 Rothberg, J.M., 2169 Kellerman, K.A., 1936 Losick, R., 525 Northrop, J.P., 1823 Rottapel, R., 390 Kelly, A.M., 1462 Lowe, J.B., 1288 Novak, U., 75 Roy, S., 1365 Kessler, D.S., 1753 Lue, N.F., 503 Nye, J.A., 667, 1451 Rubin, G.M., 444, 712, 1848 Kim, S.H., 1602 Luscher, B., 1741, 2025, 2235 O'Donnell, P.T., 885 Rudin, CM., 978 Kim, S.K., 357, 896 MacDonald, C.C, 2112 Olesen, J.T., 1714 Russell, P., 1332 Kimmel, B.E., 712 Mach, B., 1528 Olsen, H.S., 1357 Russnak, R., 764 King, D.L., 1128 Madhani, H.D., 2264 Olson, E.N., 582, 1454 Rutter, W.J., 1035 Kingston, R., 1304 Maki, R.A., 1451 Olson, E.R., 2210 Ryan, T.M., 380 Klein, W.H., 111 Maldonado, E., 1611 Orenic, T.V., 1053 Saffer, J.D., 659 Klemsz, M.J., 1451 Malim, M.H., 1014 Orkin, S.H., 1650, 1886 Sariban, E., 401 Knuth, M.W., 2048 Manak, J.R., 955 Oshima, R.G., 835 Sartorelli, v., 1811 Ko, L.J., 1650 Mandai, N., 410 Osley, M.A., 752 Sauer, R.T., 277 Kobr, M., 1528 Maniatis, T., 29, 2086 Owen, J.J.T., 1304 Sawadogo, M., 1730 Kolodziej, P.A., 313 Manley, J.L., 2112 Padgett, R.W., 1114 Scarpulla, R.C, 1023 Komberg, R.D., 503 Mariani, B.D., 1128 Paidhungat, M., 1835 Schaack, J., 1197 Martienssen, R., 331 Schibler, U., 1541

GENES & DEVELOPMENT 2413 Schier, A., 1224 Smith, I, 860 Thz, N., 1999 Weil, P.A., 1141 Schmid, A., 1688 Smith, M.R, 1875 Thiebaud, P., 1999 Weiner, A.M., 2146 Schmidt, M.C., 151 Smoller, D, 1688 Thomas, J., 1332 Weinrauch, Y., 860 Schmidt-Glenewinkel, T., 1224 Smouse, D, 1516 Thompson, C.B., 536, 548 Weintraub, H., 932 Schroeder, S., 1141 Sollner-Webb, B, 52 Thon, G., 1374 Wensink, P.C., 613 Schutz, G., 1437 Sonenberg, N, 1365 Thummel, C.S., 1451 Wickens, M., 2287 Schweisguth, F., 922 Sonoda, S, 624 Thurston, S.J., 659 Widenhom, K., 849 Scott, M.P., 624 Sorrentino, B.P, 993 Tjian, R., 822, 943, 1741 Wieschaus, E., 1209 Scottgale, T.N, 464, 2188 Spana, C, 1505 Tomlinson, A., 728 Williams, B.R.G., 1094 Searles, L.L, 559 Spears, P.A, 1172 Toth, S., 2308 Williams, J.G., 419 Segal, D, 1114 Speck, N.A., 233 Townes, T.M., 380 Wilusz, J., 2112 Segall, J, 1775 Spencer, C.A., 75 Treacy, M.N., 43 Wimmer, E., 1560 Segraves, W.A., 204 Spradling, A.C., 1516, 2242 Trun, N.J,, 2036 Windle, J.J., 52 Seraphin, B, 1766 St. Johnston, R.D., 1114 Tuggle, C.K., 180 Wobbe, C.R., 636 Shamah, S.M, 2333 Standart, N., 2157 Turk, C, 372 Wood, W.G., 1588 Shapiro, L, 1494 Steigerwald, S.D., 1277 Ueda, H., 624 Woodham, J.P., 1252 Sharma, S.B, 344 Stenlund, A., 123 Urban, M.B., 1975 Wormington, W.M., 2278 Sharp, P.A, 2383 Stewart, A.F., 1437 Umess, L.D., 1451 Woychik, N.A., 313 Sharpe, J, 1588 Stewart, E., 2157 Valdizan, M.C., 111 Wu, C., 624 Shea, MJ, 1128 Stewart, J., 1623 Van Beveren, C., 1451 Wulff, D.L., 2223 Sheldon, M, 2061 Stiles, CD., 2333 vander Vliet, P.C, 1964 Xu, M.-Q., 777 Shen, L.-P, 1035 Stillman, B., 968 Van Vactor, Jr., D.L., 1835 Xu, T., 464 Yager, L.N., 1473 Sheng,M, 255 Stoeckle, M.Y., 243 Varmus, H.E., 2342 Storb, U., 978 Yamamoto, M., 1650 Shenk, T, 1197, 2112 Vamum, S.M., 2278 Stragier, P., 525 Vassar, R., 1985 Yamazaki, K.-i., 1899 Sherratt, DJ, 2366 Straus, D., 2202 Veals, S.A., 1753 Yaoita, Y., 1917 Shi, Y.-B., 1107 Struhl, K., 636 Verrijzer, C.P., 1964 Yedvobnick, B., 1688 Shub, D.A, 777 Stueland, C.S., 1332 Vincent. A., 922 Yen, D., 728 Shuman, J, 1404 Su, L.-K., 167 Vitelh, L., 849 Young, R.A., 313 Shuman, S, 515 Su, W., 410 Vogt, P.K, 1677 Zakany, J., 180 Signer, E.B, 344 Sundin, O.H., 1267 Voss, J.W., 695 Zenke, M., 1663 Silacci, P, 1528 Sundseth, R., 287 Walbot, V, 1149 Zhong, W., 2353 Silber, K.R, 277 Susskind, M.M., 1801 Walter, W., 2202 Ziff, E.B., 477 Simmons, D.M, 695 Sutrave, P., 1462 Wang, C., 2333 Zipursky, S.L., 1835 Singer, V.L, 636 Swanson, L.W., 695 Wang, C.K., 1141 Sive, H.L, 932 Takagaki, Y., 2112 Weber, K.S., 98 Sladek, F.M, 2353 Tanguay, R.L., 1277 Webster, K.A., 1811 Slusarski, D.C, 1053 Taylor, W.C., 331 Weiffenbach, B., 1573 Smith, A.G, 2308 Temin, H.M., 2299 Weih, F., 1437 Smith, E, 1427

2414 GENES & DEVELOPMENT Subject Index, Volume 4 (1990)

domains (Hu et al), 1741-1752 (DCR) (Higgs et al.), 1588-1601 ASF-1, tobacco nuclear factor (Katagiri locus, LAR deletion causes chromatin Abdominal A [abdA] gene, Diosophila eta].), 1899-1909 and replication alterations (For­ BX-C, expression in embryos Aspergillus nidulans, light-independent rester et al.), 1637-1649 (Karch et al.), 1573-1587 conidiation (Mooney and Bithorax Complex (BX-C), Diosophila, Achaete-scute complex, Diosophila sea Yager), 1473-1482 abdA expression in embryos expression (Mlodzik et al.), (Karch et al.), 1573-1587 1848-1861 Autogenous regulation, S. ceievisiae his- tone locus (H2A-H2B) (Moran et Blastoderm cellularization, Diosophila, Adenovirus role of sry (Schweisguth et al.), ElA-mediated stimulation of VAj al), 752-763 922-931 transcription (Kovelman and Autoregulation, Diosophila ftz en­ Boss gene, Diosophila retinal cell fate Roeder), 646-658 hancers (Pick et al.), 1224-1239 (Hart etal.), 1835-1847 IVa2 promoter, TATA-like sequences Avian erythroblastosis virus (AEV), v- required for TFIID-dependent eibA oncogene (Glineur et al.), Bovine papilloma virus (BPV-1), pro­ transcription (Carcamo et al.), 1663-1676 moter repression by E2 trans- 1611-1622 Axis formation, Xenopus laevis activator (Stenlund and Bot- terminal protein, mediates binding to positional information (Cho and Ro- chan), 123-136 nuclear matrix (Schaack et al.), bertis), 1910-1916 BoxA sequence, importance in X N-me­ 1197-1208 X. laevis, RA-sensitive period (Sive et diated antitermination reaction transcription, DNA binding to nuclear al), 932-942 (Friedman et al.), 2210-2222 matrix (Schaack et al.), Axon pathways, formation requires Dio­ Burkitt's lymphoma, promoter-depen­ 1197-1208 sophila slit protein (Rothenberg dent transcription block of etal.), 2169-2187 c-myc (Spencer et al.), 75-88 Adenovirus (Ad2), El A proteins, repres­ Bursa of Fabricius, B-cell development sion of enhansons (Rochette- rearranged chicken VLI gene (Carlson Eglyetal.), 137-150 B et al.), 536-547, (McCormack Albumin promoter, D elements, LAP and Thompson), 548-558 binding to (Descombes et al.), B block promoter element, U6 snRNA 1541-1551 gene expression (Brow and Alpha-globin gene family, human, up­ Guthrie), 1345-1356 stream positive regulatory re­ Bacillus subtilis gion (Higgs et al.), 1588-1601 excision of sigK intervening element Alternative splicing (Kunkel et al.), 525-535 c-ets-2 gene induction (chicken macro­ Diosophila sex determination tia-2 genetic competence regulatory gene phages), in response to cMGF, RNA (Mattox et al.), 789-805 (Weinrauch et al.), 860-872 LPS, and PKC activators (Bou- and RNA structural changes (Nasim Bacteriophage X, OOP antisense RNA lukos etal.), 401-409 etal), 1172-1184 and cIl-O mRNA (Krinke and C-factor transmission, M. xanthus, re­ Amylase gene, regulatory element Wulff), 2223-2233 quires cell motility (Kim and (Keller et al), 1316-1321 Bacteriophage T4 Kaiser), 896-904 Antigen SSEA-1, embryonic, stage-spe­ Group 1 intron, 3' splice site selection c-/os cific (Kukowska-Latallo et al.), (Mitchel et al), 777-788 activation, of K18 enhancer (Oshima 1288-1303 mRNA decay (Mudd et al.), 873-881 et al.), 835-848 Antigenic variation, trypanosome VSG Bag-of-maibles [bam], gene, Diosophila proto-oncogene genes (Thon et al.), 1374-1383 gametogenesis (McKearin and SRF enhanced DNA binding (Manak Antiiihinum majus, floral homeotic Spradling), 2242-2251 et al.), 955-967 mutations produced by tran- Base-pairing, between U2 and U6 transcriptional repression (Rivera et sposon-mutagenesis (Carpenter snRNA (Hausner et al.), al.), 255-268 andCoen), 1483-1493 2146-2156 c-Fos, and regulation of TH gene (Gi- Antisense RNA B-cell development, bursa of Fabricius, zang-Ginsberg and Ziff), bacteriophage \ OOP (Krinke and rearranged chicken V^ genes 477-491 Wulff), 2223-2233 (McCormack and Thompson), c-/un activation, of K18 enhancer unmasks clam oocyte maternal 548-558, (Carlson et al.), (Oshima et al.), 835-848 mRNA (Standart et al.), 536-547 c-Jun protein, transformation require­ 2157-2168 B-cell-specific transcription factor, BSAP ments (Bos et al.), 1677-1687 Antitermination, X N-mediated (Barberis et al.), 849-859 c-kit point mutations, W mutant mice, (Friedman et al.), 2210-2222 Beta-galactosidase, transcriptional acti­ and developmental defects Apolipoprotein Clll gene, and HNF-4- vation, threshold event (Fiering (Reith et al.), 390-400 binding activity (Sladek et al.), etal.), 1823-1834 c-myc 2353-2365 Beta-globin promoter-dependent transcription AP-1 binding sites gene, dominant control region (Ney et block (Spencer et al.), 75-88 Diosophila, dFRA and dJRA (Perkins al), 993-1006 -related DNA-binding protein, USF et al.), 822-834 gene, dominant control region-pro­ (Gregor et al.), 1730-1740 in human p-globin dominant control moter interactions (Antoniou c-src, dominant negative SH2 mutants region (Ney et al.), 993-1006 and Grosveld), 1007-1013 of (Hirai and Varmus), AP-4 transcription factor, dimerization gene family, dominant control region 2342-2352

GENES & DEVELOPMENT 2415 C/EBP and DNA replication (Salah-ud-Din et cis-regulatory sites, sea urchin Cyllla, DNA-binding protein, homology to al), 968-977 Sped, Cyl, and SM50 genes Ig/EBP-1 (Roman et al.), £. coli, altered ploidy mutants (Trun (Thiebaud et al.), 1999-2010 1404-1415 and Gottesman), 2036-2047 CKSl homologs (human), of S. ceievi- homology to LAP (Descombes et al.), Cell fate siae CKSl and S. pombe sukl"^ 1541-1551 C. elegans lin-10 gene and vulval cell (Richardson et al.), 1332-1344 trans-activation domains (Friedman lineage (Kim and Horvitz), Class II X box, regulatory factor RFX and McKnight), 1416-1426 357-371 (ReithetaL), 1528-1540 Caenorhabditis elegans, lin-10 gene and determination, Dwsophila photore­ Clonal dynamics, of mouse hemato- vulval cell lineage (Kim and ceptors, ectopic expression of poeitic system (Jordan and Le- Horvitz), 357-371 rough (Easier et al.), 728-739 mischka), 221-232 cAMP, and TAT gene transcription rate Dwsophila retina, boss gene (Hart et cMGF (chicken myelomonocytic growth (WeithetaL), 1437-1449 al), 1835-1847 factor), and Ets2 expression in cAMP response elements (CREs), within muscle development (Olson), macrophages (Boulukos et al.), HTLV-1 LTR (Smith and 1454-1461 Commentary 401-409 Greene), 1875-1885 progression, ribonucleotide reductase Common core proteins. See Sm proteins cAMP-dependent protein kinase A, Dic- (Elledge and Davis), 740-751 Compartmentalization, B. subtilis tyostelium development (Firtel Cell division cycle, S. cerevisiae CDC46 sigma-factors and sporulation and Chapman), 18-28 protein localization (Hennessy (Kunkel et al.), 525-535 cAMP-regulated gene, Dictyostelium et al), 2252-2263 Compound eye {Dwsophila melano- SP60 (Haberstroh and Firtel), Cell motility, and M. xanthus C-sig- gaster), cis-acting requirements 596-612 naling (Kim and Kaiser), of Rh3 and Rh4 genes (Fortini Camphor resistance, E. coli altered 896-904 and Rubin), 444-463 ploidy mutants (Trun and Got- Cell-specific expression, pancreatic en­ Conidiation, light-dependent, Asper­ tesman), 2036-2047 hancer function (Nelson et al.), gillus nidulans (Mooney and Cap-independent translation, of EMCV 1035-1043 Yager), 1473-1482 virus (Jang and Wimmer), Cell-specific transcription CpG island, of X-linked PGK-1 promoter 1560-1572 HNF-3A (Lai et al.), 1427-1436 (Pfeifer et al), 1277-1287 Carboxy-terminal determinants, intra­ yeast STEll protein kinase (Rhodes et CRE (cAMP-responsive element), of cellular protein degradation al), 1862-1874 TAT gene, protein-DNA inter- (Parsell et al.), 277-286 Cellularization, of Dwsophila blasto­ actions (Weith et al.), Cardiac human actin gene, muscle-spe­ derm embryo (Schweisguth et 1437-1449 cific expression, requirements al.), 922-931 CREB/ATF, Tax protein trans-activation of (Sartorelli et al.), 1811-1822 Central nervous system (Smith and Greene), 1875-1885 Casein kinase II (CKIl), enhances SRF Dwsophila, and otd locus (Finkelstein Cross-linking, U2/U6 snRNAs (Hausner DNA binding (Manak et al.), etal), 1516-1527 et al), 2146-2156 955-967 rostrocaudal domains (Tuggle et al.), Cstf (cleavage-stimulation factor) multi- Cauliflov^^er mosaic virus (CaMV), acti­ 180-189 subunit factor, polyadenylation vation sequence-1 (as-1) ele­ Chaoptic gene, Drosophila photore­ of mammalian pre-mRNA (Ta- ment (Katagiri et al.), ceptor neurons (Pollack et al.), kagakietaL), 2112-2120 1899-1909 806-821 Cubitus interruptus Dominant (ci-D], Caulobacter, fla gene transcription, IFiF Chick, homeo box genes and hindbrain Drosophila requires (Gober and Shapiro), segmentation (Sundin and Ei- locus, compartment-specific expres­ 1494-1504 chele), 1267-1276 sion (Eaton and Kornberg), CCAAT element, HAP2/3/4 binding Chicken embryo fibroblasts (CEFs), 1069-1077 forms transcriptional activation transformation by c-Jun and segment polarity gene (Orenic et al.), complex (Olesen and Guarente), v-Jun (Bos et al.), 1677-1687 1053-1067 1714-1729 Chicken myelomonocytic growth factor. Cut locus, Drosophila, sensory organ de­ CCAAT-binding factor, serum and v-sic See cMGF. velopment (Biocklinger et al.), increase level of (Dutta et al.j, Chorion gene regulation, Dwsophila, 1322-1331 243-254 promoter-binding factors (Shea Cyclin (phosphorylated), subunit of ac­ CD4 locus, human, gene targeting by etal), 1128-1140 tive M-phase-specific HIK epitope addition (Jasin et al.), Chromatin structure (Pondaven et al.), 9-17 157-166 human (3-globin gene affected by LAR Cyclin A mRNA, masked message in CDC46 protein localization, S. ceievi- deletion (Forrester et al.), clam oocytes (Standart et al.), siae (Hennessy et al.), 1637-1649 2157-2168 2252-2263 of UASQ, influenced by GRF2 yeast Cyst formation, Drosophila and bag-of- Cell-cell interactions, Drosophila protein (Chasman et al.), marbles gene (McKearin and retina, boss protein (Hart et al.), 503-514 Spradling), 2242-2251 1835-1847 cII-O mRNA, RNase-dependent hydro­ Cytochrome c promoter, NRF-1 recogni­ Cell-cell signaling, M. xanthus C-factor lysis mediated by X OOP anti- tion site (Evans and ScarpuUa) transmission (Kim and Kaiser), sense RNA (Krinke and Wulff), 1023-1034 896-904 2223-2233 Cell cycle Cytochrome P-450 superfamily, ho­ conservation of control mechanisms Ciliogenesis, and expression of S. pui- mology to yeast D1T2 gene in eukaryotic organisms (Rich­ puratus Spec3 gene (Eldon et product (Briza et al.), ardson et al.), 1332-1344 ah), 111-122 1775-1789

2416 GENES & DEVELOPMENT arrangement (Kunkel et al.), system (Katagiri et al.), DBA-binding protein, yeast GRF2 binds 525-535 1899-1909 to UASc (Chasman et al.), DNA replication, and cell-cycle-regu­ PRDII-BFl, zinc finger motifs of recog­ lated protein phosophorylation 503-514 nize same DNA sequence (Fan (Salah-ud-Din et al.), 968-977 Deadenylation of maternal mRNAs and Maniatis), 29-42 DNA replication, human p-globin gene, oocyte maturation (Fox and Wickens), sequence-specific, ets-related genes affected by LAR deletion (For­ 2287-2298 (Guntheretal.), 667-679 rester et al), 1637-1649 oocyte maturation (Vamum and Wor- DNA-damaging agents, regulatory sub- DNA replication, S. cerevisiae CDC46 mington), 2278-2286 units of ribonucleotide reduc­ protein localization (Hennessy Decapentaplegic [dpp] gene, Drosophila tase induced by (Elledge and et al.), 2252-2263 imaginal disks (Masucci et al.), Davis), 740-751 DNA synthesis, and ribonucleotide re­ 2011-2023 DNA-nucleoprotein complex, and NGF molecular organization of (St. John­ ductase activity (Elledge and Davis), 740-751 regulation of TH gene (Gizang- ston et al.), 1114-1127 Ginsberg and Ziff), 477-491 Diabetes, mice, amylase gene expression DNA topoisomerase I, mutant alleles of (Morham and Shuman), Dominant control region (DCR), p- (Keller et al.), 1316-1321 globin Dictyostelium 515-524 development, cAMP-dependent pro­ DNA tumor viruses, p53, oncogene and cluster, human (Higgs et al.), tein kinase A (Firtel and anti-oncogene (Lane and Ben- 1588-1601 Chapman), 18-28 chimol), 1-8 Review globin, AP-1 sites fimction as induc­ regulation of cAMP-inducible genes DNase hypersensitivity, in murine im­ ible enhancer (Ney et al.), (Hjorth et al.), 419-432 munoglobulin gamma locus 993-1006 role of trans-acting factor GNF in reg­ (Hagman et al), 978-992 promoter interactions (Antoniou and ulation of (Hjorth et al.), DNase I hypersensitive (HS) sites, and Grosveld), 1007-1013 419-432 human globin gene switching Dominant-negative mutants (Behringer et al), 380-389 spore coat SP60, cis-acting regulatory of PDGF gene (Mercola et al.), DNA-binding activity, cAMP regulation regions of (Haberstroh and 2333-2341 (Weith et al), 1437-1449 Firtel), 596-612 SH2 mutants of c-src (Hirai and DNA-binding factors, sequence-specific Differentiation inhibiting activity (DLA), Varmus), 2342-2352 myogenin (Brennan and Olson), controls stem cell populations Dorsoventral axis, Drosophila, estab­ 582-595 (Rathjen et al.), 2308-2318 lishment of and Rho gene (Bier Dikaryon, plant pathogen, U. maydis DNA-binding proteins et al.), 190-203 (Kronstad and Leong), C/EBP trans-activation domains Doublesex [dsx] gene [Drosophila], cis- 1384-1395 (Friedman and McKnight), acting mutations alter sex-spe­ Dimerization specificity, transcription 1416-1426 cific RNA splicing patterns factor AP-4 (Hu et al.), c-myc-related family, USF (Gregor et (Nagoshi and Baker), 89-110 1741-1752 al.), 1730-1740 Drosophila Dimethyl sulfoxide (DMSO), induction Drosophila sl5 chorion gene (Shea et API protein, dFRA and dJRA (Perkins of globin genes in transients al), 1128-1140 et al.), 822-834 (Campbell et al.), 1252-1266 erythroid GF-1 (NF-El/Eryf 1), tran­ Bithorax Complex, abdA expression DlTl and DIT2 genes, yeast spore wall scriptional activator (Martin in embryos (Karch et al.), maturation (Briza et al.), andOrkin), 1886-1898 1573-1587 1775-1789 ETS-domain (Karim et al.), CNS development, homeo domain Dityrosine, S, cerevisiae spore wall 1451-1453 Letter protein encoded by otd (Finkel- (Briza et al.), 1775-1789 /tz-Fl, transcriptional activator of steinetal), 1516-1527 DNA, triple helix, formed by recom- Drosophila ftz (Ueda et al.), development, and E75 ecdysone-in- binase proteins (Hsieh et al.), 624-635 ducible gene (Segraves and Hog- 1951-1963 Ig/EBP-1 is homologous to C/EBP ness), 204-219 DNA bending, and protein-DNA inter­ (Roman et al), 1404-1415 dpp actions (Spana and Corces), LAP and C/EBP sequence homology expression in imaginal disks (Ma­ 1505-1515 (Descombes et al.), 1541-1551 succi et aL), 2011-2023 DNA binding, of SRF, enhanced by CKIl |xE3-binding protein TFE3 (Beckmarm gene structure (St. Johnston et al.), (Manak et al.), 955-967 etal), 167-179 1114-1127 DNA helix, stereo-specific requirements Myb oncoprotein (LUscher and Ei- dsx gene, sex-specific alternative RNA for transcription (Pape et al.), senman), 2235-2241 Review splicing of (Nagoshi and Baker), 52-61 novel domain of regulatory factor RFX 89-110 DNA looping, and gal operon (£. coli) re- (ReithetaL), 1528-1540 engrailed [en] pression (Mandal et al.), novel structure of HNF-3A (Lai et al.), gene, regulatory sequences that con­ 410-418 1427-1436 trol stripes (Kassis), 433-443 DNA methylation, CpG islands (Pfeifer oct-1 POU-specific domain and POU region-specific recombination etal.), 1277-1287 homeo domain (Verrijzer et al.), (HamaetaL), 1079-1093 DNA modification, of Mu transposable 1964-1974 represses ci-D in posterior compart­ element in maize (Martienssen Pan-1 and Pan-2 (Nelson et al.), ments (Eaton and Kornber), etal.), 331-343 1035-1043 1069-1077 DNA rearrangement, B. subtilis sigK re­ plant transcription activator in human exd affects homeo domain protein

GENES &. DEVELOPMENT 2417 function (Peifer and Wies- UBX protein and transcriptional stim­ Engrailed {en] gene [Drosophila] chaus), 1209-1223 ulation in vitro (Johnson and and exd mutations (Peifer and Wies- eye development Krasnow), 1044-1052 chaus), 1209-1223 and homeo domain rough expres­ vermilion {v) gene, 412 retrotran- regulatory sequences that control sion (Kimmel et al.), 712-727 sposon insertion (Fridell et al.), stripes (Kassis), 433-443 reprogramming cell fate (Easier et 559-566 represses ci-D in posterior compart­ al.), 728-739 ments (Eaton and Romberg), ftz gene 1069-1077 stability mutants (Kellerman et al.), Engrailed promoter, Drosophila, and re­ 1936-1950 ElA adenovirus protein, synergy with gion-specific recombination upstream element, autoregulation HIV-1 Tat (Laspia et al.), (Hamaetal), 1079-1093 of independent enhancers (Pick 2397-2408 Enhancers etal.), 1225-1239 ElA proteins, adenovirus-2 (Ad2), re­ AP-1 sites in dominant control region gametogenesis and bag-of-marbles pression of enhansons (Ro- (Ney et al), 993-1006 gene (McKearin and Spradling), chette-Egly et al.), 137-150 autoregulation of Drosophila ftz pro­ 2242-2251 EAEIA adenovirus protein, transcrip­ tein (Pick et al), 1224-1239 homeo box gene S59 expression tional stimulation of VAj gene core element, Moloney murine leu­ (Dohrmann et al), 2098-2111 (Kovelman and Roeder), kemia virus, disease specificity maternal-effect gene, vasa (Lasko and 646-658 of (Speck et al), 233-242 Ashbumer), 905-921 E2 trans-activator (BPV-1), as transcrip­ immunoglobulin gamma locus MHC genes, alternative hinge regions tional repressor (Stenlund and (Hagman et al), 978-992 (Collier et al.), 885-895 Botchan), 123-136 ovarian, of Drosophila yolk protein midline glia development and axon E75 ecdysone-inducible gene, Droso- genes (Logan and Wensink), pathway formation require slit phila (Segraves and Hogness), 613-623 protein (Rothenberg et al.), 204-219 region-specific, in mammalian CNS 2169-2187 Early response genes, avian c-ets-2 (Bou- (Tuggle et al), 180-189 nautilus [nau] gene, muscle pattern lukos etal), 401-409 within human K18 gene, activation of formation (Michelson et al.), Ecdysone response, Diosophila, genetic (Oshima et al), 835-848 2086-2097 regulatory hierarchy (Segraves Enhancer-binding factor El2, interaction neurogenesis, sea gene (Mlodzik et and Hogness), 204-219 with myogenin (Brennan and al.), 1848-1861 Ectodermal differentiation, and Droso- Olson), 582-595 neurogenic locus mastermind [mam] phila Senate gene (Fleming et Enhansons, Ad2 ElA repression of (Ro- (SmoUer et al.), 1688-1700 al), 2188-2201 chette-Egly et al), 137-150 Notch locus and earyl neurogenesis Ectopic expression, of Diosphila rough env mRNA structural region (RRE), in­ (Xu et al.), 464-475 homeo domain protein teraction with HFV-l Rev pro­ ovarian enhancers of yolk protein (Kimmel et al.), 1X1-111, tein (Olsen et al), 1357-1364 genes (Logan and Wensink), (Basler et al), 728-739 Epitope addition, gene targeting at 613-623 EGF domain, Drosophila extracellular human CD4 locus (Jasin et al), photoreceptor neurons, chaoptic gene slit protein (Rothenberg et al), 157-166 (Pollack et al.), 806-821 2169-2187 Erythrocytes, expression of transcription Rho gene, dorsoventral axis establish­ EGF locus, Drosophila Serrate gene factor NF-El (Yamamoto et al), ment and PNS development (Fleming et al), 2188-2201 1650-1662 (Bier etal), 190-203 Electron transport chain, mammalian Erythroid cells, AP-1 sites in dominant rhodopsin promoters, bipartite struc­ (Evans and ScarpuUa), control region (Ney et al), ture of (Fortini and Rubin), 1023-1034 993-1006 444-463 Embryogenesis, X. laevis, positional in­ Erythroid differentiation, gag/v-erhA sl5 chorion gene, promoter-binding formation (Cho and Robertis), protein phosphorylation factors (Shea et al.), 1128-1140 1910-1916 (Glineur et al), 1663-1676 segment polarity gene, ci° (Orenic et Embryoid bodies, globin gene expression Erythroid transcription factor, GF-1 al.), 1053-1068 (Lindenbaum and Grosveld), (NF-El/Eryf 1), activation and segmentation gene, runt sequence and 2075-2085 DNA binding by (Martin and Orkin), 1886-1898 distribution (Kania et al.), Embryonic ectoderm cells, 5. pur- Escherichia coh 1701-1713 puratus, Spec3 protein localizes carboxy-terminal determinants of in­ sensory organ development and cut to cilia and Golgi complexes tracellular degradation (Parsell locus (Blocklinger et al.), (Eldonetal), 111-122 et al), 277-286 1322-1331 Embryonic stem (ES) cells, globin gene cell cycle, altered ploidy mutants sry gene, blastoderm cellularization expression (Lindenbaum and (Trun and Gottesman), (Schweisguth et al.), 922-931 Grosveld), 2075-2085 2036-2047 su(Hw) protein-gypsy DNA interac­ Encephalomyocarditis virus (EMCV), heat shock gene expression (Strauss et tion (Spana and Corces), cap-independent translation of 1505-1515 (Jang and Wimmer), 1560-1572 al), 2202-2209 retinal cell fate and boss gene (Hart et End (3') formation, Ul snRNA gene RNA polymerase al), 1835-1847 (Gunderson et al), 2048-2060 3-subunit, termination-altering muta- tia-2 sex determination gene, alterna­ Endoribonuclease activity, and X. laevis tions (Landick et al.), tive splicing (Mattox et al.), RNA stability (Brown and 1623-1636 789-805 Richard), 1925-1935 pseudo-templated transcription

2418 GENES & DEVELOPMENT (Jacques and Susskind), (Kukowska-Latallo et al.), human 1801-1810 1288-1303 induction by HMBA and DMSO RNase E, role in T4 mRNA decay Fushi tarazu [ftz], Drosophila (Campbell et al), 1252-1266 (Mudd et al.), 873-881 autoregulation of independent en­ gene switching, in transgenic mice ets proto-oncogene family, MSV LTR hancers (Pick et al.), 1224-1239 (Behringer et al.), 380-389 promoter binding (Gunther et stability mutants (Kellerman et al.), switching, in vitro model (Linden­ al.), 667-679 1936-1950 baum and Grosveld), Ets2 expression, in chicken macrophages transcriptional activator of (Ueda et 2075-2085 (Boulukos et al.), 401-409 al.), 624-635 Golgi complexes, S. purpuratus embry­ ETS-domain, eukaryotic DNA-binding F-actin, and Drosophila sry protein onic ectoderm cells, and Spec3 proteins (Karim et al.), (Schweisguth et al), 922-931 protein (Eldon et al.j, 111-122 1451-1453 Letter GRF2 yeast protein, binds to UASQ Even-skipped [eve], and Drosophila seg­ creating nucleosome-free region mentation defects (Kellerman (Chasman et al.), 503-514 etal.), 1936-1950 GRM factor, yeast, same as PRTF factor GAL upstream activating sequence. See Evolution, studies of testis-determining (Ammerer), 299-312 Y genes (Zfy-1 and Zfy-2] in UASG Group I introns, 3' splice site selection Galactose {gal] operon, E. coli, DNA genus Mus (Nagamine et al.), (Mitchel et al.), 777-788 looping and repression of 63-74 Growth factors. See also Nerve growth (Mandal et al.), 410-418 Exradenticle [Exd] gene, Drosophila, factor mutation affects homeo domain Gametogenesis, Drosophila, initiated by DIA/LIF controls stem cell popula- protein function (Peifer and bag-of-marbles gene (McKearin tions (Rathjen et al.), Wieschaus), 1209-1223 and Spradling), 2242-2251 2308-2318 Extracellular matrix (ECM) deposition, Gamma delta RNA (78 RNA), activation dominant-negative mutants of PDGF of (Carding et al), 1304-1315 mice, role of TIMP (Fleimiken (Mercola et al), 2333-2341 Gamma gene regulation, independent and Williams), 1094-1106 mesoderm induced, X. laevis homeo activation (Hagman et al.), Extracellular protein, Drosophila slit box gene activation (Cho and 978-992 (Rothenberg et al.), 2169-2187 Robertis), 1910-1916 Eye development, Drosophila sea gene GBF, trans-acting GBRE binding factor (Hjorthetal.), 419-432 (Mlodzik et el), 1848-1861 H Gene batteries, sea urchin embryos (Thiebaud et al.), 1999-2010 Half-helical turn spacing changes, con­ Gene conversion vert frog into mouse rDNA pro­ chicken, VLl, donor preference and moter (Pape et al.), 52-61 F9 embryonal carcinoma cells, K18 in- polarity (McCormack and Heat shock proteins, £. coh DnaK, DnaJ, tron activation (Oshima et al.), Thompson), 548-558 and GrpE, sigma^^ regulation 835-848 intrachromosomal, and rearranged (Straus et al.), 2202-2209 FACS/Gal assay, NF-AT transcriptional chicken IgL V gene segment HeLa cells activity (Fiering et al.), (Carlson et al.), 536-547 LSF (late SV40 factor) transcription 1823-1834 Gene targeting, at human CD4 locus factor (Huang et al.), 287-298 Fetal liver, TCR 78 gene expression (Jasin et al.), 157-166 purification of SF2 splicing factor (Carding et al.), 1304-1315 Gene switching, globin, in vitro model (Krainer et al.), 1158-1171 Finger DNA-binding proteins, erythroid (Lindenbaum and Grosveld), Helix-loop-helix factor GF-1 (NF-El/Eryf 1) 2075-2085 domain (Martin and Orkin), 1886-1898 Genetic competence, B. subtilis, regula­ Drosophila nau gene (Michelson et fix genes {R. meliloti), in planta, regula­ tory gene (Weinrauch et al.), al.), 2086-2097 tion of (Sharma and Signer), 860-872 of myogenic regulatory factors 344-356 Genetic interactions, Drosophila Notch (Olson), 1454-1461 Commen­ Flagellar genes [fla], Caulobacter, tran­ locus (Xu et al.), 464-475 tary scription requires IHF (Gober Genetic screening, of DNA topoiso- USF regulatory DNA-binding pro­ and Shapiro), 1494-1504 merase I mutant alleles tein (Gregor et al.), 1730-1740 Flourescence-activated cell sorter, anal­ (Morham and Shuman) motif, of TFE3 (Beckmann et al.), ysis of NF-AT transcriptional 515-524 167-179 activity among T cells (Fiering Genomic sequencing, X-linked CpG is­ protein, transcription factor AP-4 (Hu etal.), 1823-1834 land (Pfeifer et al.), 1277-1287 etal.), 1741-1752 Flower development. Antirrhinum Ghox-lab homeo domain protein, chick, Hematopoiesis (mice), clonal and sys­ mains homeotic mutations hindbrain segmentation temic analysis (Jordan and Le- (Carpenter and Coen), (Sundin and Eichele), mischka), 220-232 1483-1493 1267-1276 Hematopoietic development, ES cell Fos-related protein, Drosophila AP-1 Glial cells, Drosophila, and slit protein system (Lindenbaum and Gros­ dFRA (Perkins et al.), 822-834 (Rothenberg et al), 2169-2187 veld), 2075-2085 Fruiting body formation, M. xanthus Globin gene Hepatitis B viruses, reverse transcription (Apelian and Inouye), expression, transcriptional regulation (Russnak and Ganem), 764-776 1396-1403 mechanisms, GF-1 (NF-El/ Hepatocyte-specific factor, HNF-3A, reg­ Fucosyltransferase, Lewis blood group, Eryf 1) erythroid factor (Martin ulated transcriptionally (Lai et determines SSEA-1 expression and Orkin), 1886-1898 al.), 1427-1436

GENES & DEVELOPMENT 2419 Herpes simplex virus (HSV), interaction ducing growth factors and RA gene conversion (Carlson et al.), of TIF with Oct-1 POU subdo- (Cho and Robertis), 1910-1916 536-547 mains (Kristie and Sharp), Homeo domain, of oct-1 POU domain genes, chicken, VLI pseudogene donor 2383-2396 (Verrijzer et al), 1964-1974 preference and polarity (McCor- Herpes virus family, pseudorabies IE Homeo domain proteins mack and Thompson), 548-558 protein (Martin et al.), Drosophila heavy-chain enhancer (IgH), \i.E3 motif 2376-2382 exd affects function of (Peifer and (Beckmarm et al.), 167-179 Heteromeric protein-protein interac­ Wieschaus), 1209-1223 transcription, Ig/EBP-1 is homologous tion, HAP2/3/4 CCAAT- otd locus, necessary for CNS devel­ to DNA-binding protein C/EBP binding complex (Olesen and opment (Finkelstein et al.), (Roman et al.), 1404-1415 Guarente), 1714-1729 1516-1527 In vitro integration, of yeast Tyl retro- Hexamethylene bisacetamide (HMBA), rough, expression and misexpres- transposon (Eichinger and induction of globin genes in sion of (Kimmel et al.), Boeke), 324-330 transients (Campbell et al.), 712-727 Induction, globin genes, by HMBA and 1252-1266 HNF-1 transcription factor is broadly DMSO (Campbell et al.), Hindbrain development, chick, meta- expressed (Baumhueter et al.), 1252-1266 meric pattern (Sundin and Ei- 372-379 Initiation chele), 1267-1276 Homeosis, Drosophila segmentation E. coli, translation (Hartz et al.), Histone genes, S. cerevisiae balanced genes (Kellerman et al.), 1790-1800 synthesis (Moran et al.), 1936-1950 transcription, E. coli, RNA poly­ 752-763 Homeotic mutations, floral, in Antirr­ merase (Jacques and Susskind), Histone HI kinase (HIK), M-phase-spe- hinum majus (Carpenter and 1801-1810 cific, activation of (Pondaven et Coen), 1483-1493 Insulin-dependent element (IDE), pan­ al.), 9-17 Homologous recombination, interme­ creatic amylase gene (Keller et HIV-1 diate three-stranded DNA al.), 1316-1321 gene expression, combined effects of (Hsieh et al.), 1951-1963 Integration host factor (IHF), transcrip­ trans-activators on (Laspia et Hormonal regulation, Drosophila E75 tional activation of fla genes al.), 2397-2408 ecdysone-inducible gene (Se- (Gober and Shapiro), LTR, inducer of short transcripts (1ST) graves and Hogness), 204-219 1494-1504 (Ratnasabapathy et al.), HS sites (DNase I hypersensitive), and Interferon, regulation of ISGF3 nuclear 2061-2074 human globin gene switching translocation (Kessler et al.), Rev, RNA response element (Ahmed (Behringer et al.), 380-389 1753-1765 etal.), 1014-1022 HTLV-1 Interferon-stimulated gene factor-3 Rev protein, interaction w^ith struc­ Rex, RNA response element (Ahmed (ISGF3), nuclear translocation tured region within env mRNA etal.), 1014-1022 and DNA binding affinity of (RRE) (Olsen et al), 1357-1364 tax gene mutants (Smith and Greene), (Kessler et al.), 1753-1765 TAR RNA, Tat binding (Roy et al.), 1875-1885 Interferon-p gene promoter (human), 1365-1373 Hypersensitive sites, enhancer within PRDII-BFl zinc finger motifs HNF-1 transcription factor, broadly HSII (Ney et al.), 993-1006 bind to regulatory domain of acting homeo domain protein H-2K'' gene promoter, PRDIl-BFl protein (Fan and Maniatis), 29-42 (Baumhueter et al.), 372-379 binding to (Fan and Maniatis), Interleukin-2, transcriptional activation HNF-3A transcription factor, cell-spe­ 29-42 (Fiering et al), 1823-1834 cific regulation of (Lai et al.), In vivo DMS footprinting, active and in­ 1427-1436 active X chromosome (Pfeifer et I HNF-4 transcription factor, novel ste­ al.), 1277-1287 roid receptor family member IE protein (pseudorabies virus), tran­ 1ST (inducer of short transcripts), HIV-1 (Sladek et al.), 2353-2365 scriptional activator (Martin et LTR (Ratnasabapathy et al.), Homeo box al), 2376-2382 2061-2074 Drosophila BX-C (Karch et al.), IF3, E. coli translation initiation (Hartz 1573-1587 etal.), 1790-1800 of Oct-1 (Kristie and Sharp), Imaginal disk development, Drosophila, K 2383-2396 and dpp gene (St. Johnston et Kappa gene regulation, independent ac­ X. laevis Xlhbox2 mRNA stability al.), 1114-1127 tivation (Hagman et al.), (Brown and Richard), Imaginal disks, Drosophila dpp expres­ 978-992 1925-1935 sion (Masucci et al.), 2011-2023 Keratin 18 gene, human, c-/os and c-jun Homeo box genes Immediate early genes, c-/os transcrip­ activation of enhancer (Oshima chick hindbrain segmentation (Sundin tional repression (Rivera et al.), et al.), 835-848 andEichele), 1267-1276 255-268 Keratinocytes, human epidermal keratin Drosophila S59 (Dohrmann et al.), Immune response, MHC class II regula­ gene expression (Leask et al.), 2098-2111 tory factor RFX (Reith et al.), 1985-1998 Drosophila rough, photoreceptor spec­ 1528-1540 ification (Basler et al.), 728-739 Immunoglobulin mammalian Hox-1.3 and Hox-5.1, and gamma locus, enhancers (Hagman et region-specific enhancers al.), 978-992 Lac repressors (£. coli], and DNA (Tuggle et al.), 180-189 genes, chicken V^ sequence diversity looping in gal operon (Mandal X. laevis, activation by mesoderm-in- as result of intrachromosomal et al.), 410-418

2420 GENES & DEVELOPMENT Lambda repressor, proteolysis in £. coli Maternal mRNAs Wnt-l/int-1-related gene family (Parsell et al.), 277-286 clam oocytes, unmasked by antisense (Gavin et al.), 2319-2332 LAP (liver transcriptional activator pro­ RNA (Standart et al.), dominant-negative mutant of PDGF tein), sequence homology to 2157-2168 gene (Mercola et al.), C/EBP (Descombes et al.), deadenylation during Xenopus oocyte 2333-2341 1541-1551 maturation (Vamum and Wor- erythroleukemia cells (MELCs), tran­ Leucine repeat elements, transcription mington), 2278-2286, (Fox and sient transfection, HMBA in­ factor AP-4 dimerization motif Wickens), 2287-2298 creases globin gene expression (Huetal.), 1741-1752 Maternal-effect gene, vasa protein poste­ (Campbell et al.), 1252-1266 Leucine-rich repeats, Diosophila extra­ rior localization (Lasko and TCR 78 gene expression (Carding et cellular slit protein (Rothenberg Ashbumer), 905-921 al.), 1304-1315 et al.), 2169-2187 Mating response pathway, yeast, STEII mRNA, TMV 3'-untranslated region Leukemia inhibitory factor (LIF), con­ protein kinase (Rhodes et al.), (UTR) (Gallie and Walbot), trols stem cell populations 1862-1874 1149-1157 (Rathjen et al.), 2308-2318 Mating-specific promoter elements, mRNA decay, bacteriophage T4, role of Lewis blood group, human, fucosyl- yeast, and PRTF/GRM (Am- E. coli RNase E (Mudd et al.), transfersase (Kukowska-La- merer), 299-312 873-881 talloetal.), 1288-1303 Mating-type locus, b, U. maydis (Kron- mRNA processing, polyadenylation LF-Al DNA-binding activity, similarity stad and Leong), 1384-1395 factor Cstf (Takagaki et al.), to HNF-4 (Sladek et al.), MCMl gene, yeast, encodes DNA- 2112-2120 2353-2365 binding component of PRTF mRNA splicing, base-pairing between lin-10 gene (C. elegans], and vulval cell and GRM (Ammerer), 299-312 U2 and U6 snRNA (Hausner et fates (Kim and Horvitz), Mesoderm development, Diosophila al.), 2146-2156 357-371 nan gene, pattern formation MRP RNA gene, NRF-1-binding site Liver, transcriptional activator protein (Michelson et al.), 2086-2097 (Evans and Scarpulla), (LAP) (Descombes et al.), Mesoderm induction, of X. laevis homeo 1023-1034 1541-1551 box genes (Cho and Robertis), Mu transposable element, DNA modifi­ Liver-specific gene expression, HNF-4 1910-1916 cation in maize (Martienssen et (Sladek et al.), 2353-2365 Mesodermal cells, Diosophila homeo al.), 331-343 Locus activating region (LAR), deletion box gene S59 expression (Dohr- Multiallelic gene, U. maydis h mating- of human ^-globin locus (For­ mannetal.), 2098-2111 type locus (Kronstad and rester et aL), 1637-1649 Metamorphosis, X. laevis Leong), 1384-1395 Locus activation, HS sites and globin pancreatic gene regulation (Shi and Multigene family, NF-El (Yamamoto et loci (Behringer et al), 380-389 Brown), 1107-1113 aL), 1650-1662 Long terminal repeat (LTR), of RSV, and thyroid hormone receptor families Multisubunit factor Cstf, polyadenyla­ transcription from (Dutta et al.), (Yaoita and Brown), 1917-1924 tion of mammalian pre-mRNA 243-254 Mice, clonal dynamics of hematopoietic (Takagaki et al.), 2112-2120 Looping (DNA), and gal operon (£. coli] system (Jordan and Lemischka), Muscle repression (Mandal et al,), 220-232 creatine kinase (MCK) enhancer, af­ 410-418 Midgut cells, Diosophila homeo box finity of myogenin-E12 for LSF HeLa transcription factor, two gene S59 expression (Dohrmann (Brennan and Olson), 582-595 variant SV40 binding sites etal), 2098-2111 development (Huang et al.), 287-298 Mitochondrial genetic system, NRF-1- Diosophila homeo box gene S59 ex­ Lymphoid-specific genes, and POU binding sites (Evans and Scar- pression (Dohrmann et al.), homeo domain protein Oct-2 puUa), 1023-1034 2098-2111 (Elsholzetal.), 43-51 Moloney murine leukemia virus, disease Diosophila nau gene, pattern for­ specificity of enhancer core ele­ mation (Michelson et al.), ment (Speck et al.), 233-242 2086-2097 Moloney murine sarcoma virus (MSV), Diosophila MHC genes, hinge regions M long terminal repeat (LTR) pro­ (Collier etal.), 885-895 M6 and M9 alleles, SH2 mutants of c-src moter, proto-oncogene ets-1 skeletal, and ski oncogene (Sutrave et (Hirai and Varmus), 2342-2352 binding (Gunther et al.), aL), 1462-1472 Macrophages (chicken), Ets2 expression 667-679 Muscle-specific expression, human car­ in (Boulukos et al), 401-409 Monoclonal antibody MAb24B10, speci­ diac actin gene, requirements of Maize, suppressible mutation (hcfl06) ficity for Diosophila photore­ (Sartorelli et al.), 1811-1822 controlled by Mu transposable ceptors and neurons (Pollack et Muscle-specific genes, interaction with element (Martienssen et al.), al.), 806-821 myogenin-E12 (Brennan and 331-343 Morphogenesis, M. xanthus fruiting Olson), 582-595 Major histocompatibility complex body, C-signaling (Kim and Muscle-specific transcription, and (MHC), class II regulatory factor Kaiser), 896-904 MyoD family (Olson), RFX (Reith et al.), 1528-1540 Mouse 1454-1461 Commentary Masking and unmasking, clam oocyte development Myb oncoprotein, transcriptional regula­ maternal mRNA (Standart et stage-specific embryonic antigen tion (Liischer and Eisenman), al), 2157-2168 SSEA-1 (Kukowska-Latallo et 2235-2241 Review Mastermind [mam] neurogenic locus, al.), 1288-1303 Myc, molecular function (review) Diosophila (Smoller et al.), TIMP gene expression (Flenniken (Liischer and Eisenman), 1688-1700 and Williams), 1094-1106 2025-2035

GENES &. DEVELOPMENT 2421 MyoD family, Drosophila nau gene (Mi- scription initiation (Fiering et and p53 gene (Lane and Benchimol), chelson et al.), 2086-2097 al.), 1823-1834 1-8 Review MyoD gene family and myogenesis NF-El transcription factor, developmen- ski and skeletal muscle growth (Su- (Olson), 1454-1461 Commen­ tally regulated multigene traveet al.), 1462-1472 tary family (Yamamoto et al.), v-erbA, phosphorylation of protein re­ MyoDl, binding to human cardiac actin 1650-1662 quired for function (Glineur et gene (Sartorelli et al.), nif genes [R. meliloti], in planta, regula­ al.), 1663-1676 1811-1822 tion of (Sharma and Signer), v-jun and c-jun (Bos et al.), 1677-1687 Myogenesis 344-356 Oncoprotein, Myb (Liischer and Ei­ Drosophila nau gene and pattern for­ nod genes [R. meliloti], in planta, regula­ senman), 2235-2241 Review mation (Michelson et al.), tion of (Sharma and Signer), Orthodenticle [otd] locus, Drosophila, 2086-2097 344-356 encodes homeo domain protein quail qmfl expression (de la Brousse Notch locus, Drosophila necessary for CNS development and Emerson), 567-581 and early neurogenesis (Xu et al.), (Finkelstein et al.), 1516-1527 Myogenic regulatory genes, MyoD 464-475 Ovarian enhancers. See Enhancers family (Olson), 1454-1461 interaction with EGF-containing Ser­ Commentary rate locus (Fleming et al.), Myogenin, sequence-specific DNA- 2188-2201 binding factor, interaction with NRF-1 trans-activator, activation of nu­ P element integration, Drosophila en­ muscle-specific genes (Brennan clear respiratory genes (Evans grailed region (Hama et al,), and Olson), 582-595 and ScarpuUa), 1023-1034 1079-1093 Myosin heavy chain (MHC) genes, Dio- Nuclear matrix, adenovirus DNA associ- p34cdc2 (dephosphorylated), subunit of sophila, alternate hinge regions ation (Schaack et al.), active M-phase-specific HIK (Collier et al), 885-895 1197-1208 (Pondaven et al.), 9-17 Myotome formation, quail qmfl mRNA Nuclear protein p53 gene, oncogene and anti-oncogene activation (de la Brousse and encoded by Drosophila mam neuro­ (Lane and Benchimol), 1-8 Re­ Emerson), 567-581 genic locus (Smoller et al.), view Myxococcus xanthus 1688-1700 Pair-rule gene, Drosophila runt (Kania et C-factor signaling, cell motility re­ encoded by Drosophila runt segmen­ al), 1701-1713 quired (Kim and Kaiser), tation gene (Kania et al.), Pancreas 896-904 1701-1713 amylase gene expression in diabetic development-specific factor (Apelian Nuclear respiratory genes, NRF-1 acti­ mice (Keller et al.), 1316-1321 and Inouye), 1396-1403 vation (Evans and Scarpulla), -specific gene expression enhancer reg- M-phase-specific, histone HI kinase, ac- 1023-1034 ulation (Nelson et al.), tiviation of (Pondaven et al.), Nuclear RNA polymerases (eukaryotic), 1035-1043 9-17 common subunits of (Woychik X. laevis, changes during metamor­ etal.), 313-323 phosis (Shi and Brown), N Nuclear translocation, of ISGF3, regula­ 1107-1113 tion by IFN (Kessler et al.), Nerve growth factor (NGF), regulation of Pancreatic nuclear protein, PTFl, and 1753-1765 tyrosine hydroxylase gene (TH) amylase gene expression (Keller Nut phage X sites, contain boxA tran­ (Gizang-Ginsberg and Ziff), etal), 1316-1321 scription signal (Friedman et 477-491 Pattern formation, Drosophila al.), 2210-2222 Neurogenesis, Drosophila and dpp gene (St. Johnston et al.), characterization of mam (Smoller et 1114-1127 O al.), 1688-1700 imaginal disks (Masucci et al.), and Notch locus (Xu et al.), 464-475 Octamer sequence, contact points with 2011-2023 sea gene (Mlodzik et al.), 1848-1861 oct-1 (Verrijzer et al.), muscle development (Michelson et Neurogenic gene, Drosophila Notch 1964-1974 al.), 2086-2097 locus, interaction with Serrate- Octamer-binding proteins, Oct-1 POU sea expression (Mlodzik et al.), gene (Fleming et al.), interaction with HSV TIF 1848-1861 2188-2201 (Kristie and Sharp), 2383-2396 Peripheral nervous system, Drosophila Neurogenic locus, Drosophila mam Oct-1 (octamer-binding protein), POU- Drosophila development, and Rho (Smoller et al.), 1688-1700 specific domains and POU gene (Bier et al.), 190-203 Neurogenic loci [Drosophila], genetic in­ homeo domain (Verrijzer et al.), sea gene (Mlodzik et al.), 1848-1861 teractions (Xu et al.), 464-475 1964-1974 sensory organ development (Block- Neuronal cells, Drosophila homeo box Oct-2, POU homeo-domain protein, linger et al.), 1322-1331 gene S59 expression (Dohrmann lymphoid-specific gene expres­ Phage X, termination and antitermina- etal), 098-2111 sion (Elsholz et al.), 43-51 tion (Friedman et al.), NF-KB Oligosaccharide antigen, SSEA-1 (Ku- 2210-2222 Tax protein trans-activation (Smith kowska-Latallo et al.), Phage P22, mutant sar promoter and Greene), 1875-1885 1288-1303 (Jacques and Susskind), transcription factor, interactions be­ Ommatidial assembly, Drosphila 1801-1810 tween three subunits of (Urban (Kimmel et al.), 712-727 Phenotypic screening, of DNA topoiso- and Baeuerle), 1975-1984 Oncogenes merase I mutant alleles NF-AT transcription factor, concentra­ myc (Liischer and Eisenman), (Morham and Shuman), tion threshold required for tran­ 2025-2035 Review 515-524

2422 GENES & DEVELOPMENT Pheromone response, yeast, and over­ Polytene chromosome puffing, Droso­ ribosomal DNA (McStay and production of STE12 protein phila, and ecdysone hormone Reeder), 1240-1251 (Dolan and Fields), 492-502 (Segraves and Hogness), recognition, eukaryotic cells (Bell et Phosphoglycerate kinase-1 (PGK-1) gene, 204-219 al), 943-954 human X-linked CpG island Positional information, Drosophila ima- Ul snRNA, in vitro transcription ini­ (Pfeifer et al.), 1277-1287 ginal disk dpp gene (Masucci et tiation (Gunderson et al.), Phosphorylation, oncogene v-erbA pro­ al.), 2011-2023 2048-2060 tein product (Glineur et al.), Posterior group genes, Drosophila vasa Promoter-dependent, transcription elon­ 1663-1676 (Lasko and Ashburner), gation blockage of c-myc Photoinduced development, A. nidulans 905-921 (Spencer et al.), 75-88 conidiations (Mooney and POU domain Protein degradation, intracellular, car- Yager), 1473-1482 of oct-1 binding protein (Verrijzer et boxy-terminal determinants of Photoreceptor cells, Drosophila al), 1964-1974 (Parsell et al.), 277-286 compound eye (Fortini and Rubin), POU-specific box and POU homeo Protein-DNA interactions 444-463 box of Oct-1 (Kristie and Sharp), Drosophila su(Hw) protein-gypsy neuron, chaoptic gene (Pollack et al.), 2383-2396 DNA (Spana and Corces), 806-821 POU homeo domain proteins 1505-1515 subtype specification and rough Pit-1 and Oct-2, binding sites (Elsholz MyoD, SRF, and Spl with human car­ (Kimmel et al.), 712-727 etal), 43-51 diac actin gene (Sartorelli et al.), Pituitary-specific genes, and POU transcriptional activators (Baum- 1811-1822 homeo domain protein Pit-1 hueter et al.), 372-379 Protein kinase (PKC activators), and (Elsholz et al.), 43-51 PRDll-BFl DNA binding protein, human Ets2 expression in chicken mac­ Pit-1, POU homeo domain protein, pitu­ lFN-3 gene promoter, zinc rophages (Boulukos et al.), itary-specific gene expression finger motifs of (Fan and Man- 401-409 (Elsholz et al.), 43-51 iatis), 29-42 Protein kinase A (PKA), cAMP-depen- Plant pathogen, U. maydis, h locus mul- Preinitiation complexes, human, acti­ dent, Dictyostelium develop­ tiallelic recognition (Kronstad vated by plant DNA-binding ment (Firtel and Chapman), and Leong), 1384-1395 protein (Katagiri et al.), 18-28 Plant transcription activator, in human 1899-1909 Protein localization, S. cerevisiae system (Katagiri et al.), Preprotachykinin pre-mRNA, alterna­ CDC46 (Fiennessy et al.), 1899-1909 tive splicing of (Nasim et al.), 2252-2263 Platelet-derived growth factor (PDGF) 1172-1184 Protein phosphorylation, cell cycle regu­ gene, dominant-negative mu­ Prespore gene, Dictyostelium SP60, lated, and DNA replication tants of (Mercola et al.), cAMP regulated (Haberstroh (Salah-ud-Din et al.), 968-977 2333-2341 andFirtel), 596-612 Protein-protein interactions Ploidy, (altered) mutants, camphor resis­ Pre-mRNA DNA looping in E. coli gal operon tant, £. coli (Trun and Got- alternative splicing of (Nasim et al.), (Mandal et al.), 410-418 tesman), 2036-2047 1172-1184 Oct-1/TIF/Cl factor complex (Kristie Pole cells, Dwsophila (Lasko and Ash- interaction of splicing and polyadeny­ and Sharp), 2383-2396 burner), 905-921 lation factors (Niwa et al.), Proteolytic determinants, of lambda re­ Poly (A) 1552-1559 pressor in E. coli (Parsell et al.), sites, differential site selection, hepa­ polyadenylation, cleavage-stimulation 277-286 titis B (Russnak and Ganem), factor (CstF) (Takagaki et al.), Proto-oncogenes. See also specific 764-776 2112-2120 names removal of maternal mRNAs, oocyte splicing c-kit, point mutations in W mice maturation (Vamum and Wor- RNA-protein and protein-protein (Reith et al.), 390-400 mington), 2278-2286, (Fox and interactions (Bordonne et al.), Wnt-l/im-1 (Gavin et al.), 2319-2332 Wickens), 2287-2298 1185-1196 Proto-oncoprotein ets-l, sequence-spe­ tail, TMV RNA pseudoknot substi­ yeast, role of Ul snRNA (Liao et al.), cific DNA-binding protein tutes for (Gallic and Walbot), 1766-1774 (Gunther etal.), 667-679 1149-1157 Promoters PRTF factor, yeast, same as GRM factor Polyadenylation p-globin gene, dominant control re­ (Ammerer), 299-312 distance-dependent (cap site to poly(A) gion interactions (Antoniou and PSE, of human Ul snRNA gene (Gun­ site) (Iwasaki and Temin), Grosveld), 1007-1013 derson et al.), 2048-2060 2299-2307 BPV-1 PI, repression of by E2 trans- Pseudogene factor CstF, required for mammalian activator (Stenlund and Bot- segments, chicken VLI donor prefer­ mRNA processing (Takagaki et chan), 123-136 ence for (McCormack and al.), 2112-2120 D. melanogaster rhodopsin genes, bi­ Thompson), 548-558 masking proteins (Standart et al.), partite structure (Fortini and Trypanosomes, recombination yields 2157-2168 Rubin), 444-463 ordered expression of VSG stimulated by upstream intron (Niwa eukaryotic, TATA element replace­ genes (Thon et al.), 1374-1383 etal.), 1552-1559 ments (Singer et al.), 636-645 Pseudoknots. See RNA pseudoknots human IFN-p gene, protein binding to Polymerase III promoter element, and Pseudorabies virus, IE protein transcrip­ regulatory domain (Fan and transcription of yeast U6 tional activation (Martin et al.), Maniatis), 29-42 snRNA gene (Brow and 2376-2382 interaction with terminator, X. laevis Guthrie), 1345-1356 Pseudo-templated transcription, by E.

GENES & DEVELOPMENT 2423 coli RNA polymerase (Jacques Retroviral pathogenesis, mouse C-type polymerase I and Susskind), 1801-1810 (Speck et al.), 233-242 eukaryotic, transcriptional ma­ Retroviruses, SNV, distance-dependent chinery (Pape et al.), 52-61 polyadenylation (Iwasaki and X. laevis, terminator-promoter in­ qmfl, myogenic regulatory gene, expres­ Temin), 2299-2307 teraction (McStay and Reeder), sion in quail embryos (de la Rev protein, HIV-1 (Ahmed et al.), 1240-1251 Brousse and Emerson), 567- 1014-1022 polymerase 11, orientation dependent 581 interaction with RRE RNA (Olsen et recognition of AD IVa2 pro­ al.), 1357-1364 moter initiator (Carcamo et al.), Reverse transcription 1611-1622 transcription hepatitis B viruses polymerase 111 rDNA promoter, frog, half helical turn (Russnak and Ganem), 764-776 inhibition by Sarkosyl (Kovelman spacing changes (Pape et al.), and yeast Tyl transposition (Eichinger and Roeder), 646-658 52-61 and Boeke), 324-330 and U6 snRNA gene expression RecA protein, homologous recombina­ Rex protein, HTLV-1 (Ahmed et al.), (Brow and Guthrie), 1345-1356 tion (Hsieh et al), 1951-1963 1014-1022 yeast, transcriptional initiation Recombinase proteins, and triple- Rhizobium meliloti, symbiotic genes, in (Singer et al.), 636-645 stranded DNA (Hsieh et al.), planta, regulation of (Sharma processing, and 3'-end formation in X. 1951-1963 and Signer ), 344-356 laevis (Labhart and Reeder), Recombination Rhodopsin genes [Drosophila melano- 269-276 region-specific, Drosophila engrailed gaster], bipartite promoter pseudoknot, TMV, substitutes for promoter (Hama et al.), structure (Fortini and Rubin), poly(A) tail (Gallic and Walbot), 1079-1093 444-463 1149-1157 site-alignment (Tn3 res/resolvase) Rhomboid (Rho), Drosophila gene, dor- response elements, HTLV-1 Rex and (Bednarz et al), 2366-2375 soventral axis establishment HlV-1 Rev (Ahmed et al.), Regulatory proteins, helix-loop-helix and PNS development (Bier et 1014-1022 group, USF (Gregor et al.), al), 190-203 secondary structure, and RNA re­ 1730-1740 Rhombomeres, chick hindbrain segmen­ sponse elements (Ahmed et al.), Regulatory factor RFX, of MHC class II, tation (Sundin and Eichele), 1014-1022 DNA-binding and dimerization 1267-1276 short transcript synthesis by HIV-1 domain (Reith et al.), Ribonuclease E, degradation of T4 LTR (Ratnasabapathy et al.), 1528-1540 mRNA (Mudd et al), 873-881 2061-2074 Regulatory region, positive upstream, Ribonucleotide reductase, regulatory splicing human globin genes (Higgs et subunits of (Elledge and Davis), alternative, Drosophila MHC genes al.), 1588-1601 740-751 (Collier et al.), 885-895 Replication factor (RF-A), cell-cycle-reg­ Ribonucleotide reductase mRNA, Drosophila dsx gene, sex-specific ulated phosophorylation (Salah- masked message in clam oo­ patterns and cis-acting muta­ ud-Din et al.), 968-977 cytes (Standart et al.), tions (Nagoshi and Baker),89- Repression, of enhanson activity, by A2 2157-2168 110 El A proteins (Rochette-Egly et Ribosomal genes, RNA 3'-end formation SF2 splicing factor, purification al.), 137-150 and transcription termination from HeLa cells (Krainer et al.), Repressor, of transcription, E2 trans-ac­ are separable events (Labhart 1158-1171 tivator (Stenlund and Botchan), and Reeder), 269-276 3' splice site selection (Mitchel et 123-136 Ribosomal internal entry, translation of al), 777-788 Resolution selectivity, Tn3 res recombi­ EMCV mRNA (Jang and stability, X. laevis homeo box nation site (Bednarz et al.), Wimmer), 1560-1572 Xlhbox2 mRNA (Brown and 2366-2375 RNA Richard), 1925-1935 Resolvase, Tn3 res site alignment (Bed­ -binding protein, involvement in cap- U2, secondary structure (Hartshome narz et al.), 2366-2375 independent translation of and Agabian), 2121-2131 Retina, Drosophila photoreceptor neu­ EMCV (Jang and Wimmer), RNase Ill-dependent hydrolysis, of Xcll- rons, chaoptic gene (Pollack et 1560-1572 O mRNA (Krinke and Wulff), al.), 806-821 3'-end formation in X. laevis (Labhart 2223-2233 Retinoic acid (RA) and Reeder), 169-176 Rough expression, and Drosophila eye activation of X. laevis homeo box localization, subcellular chaoptic gene development (Basler et al.), genes (Cho and Robertis), (Pollack et al.), 806-821 728-739, (Kimmel et al.j, 1910-1916 pol 1, species specific recognition (Bell 712-727 X. laevis, axis formation alteration et al.), 943-954 Rous sarcoma virus (RSV), transcription (Sive et al), 932-942 polymerase from LTR (Dutta et al.), Retrotransposon, p-subunit (£. coli], transcription 243-254 412 insertion, Drosophila vermilion pausing and termination (Lan- RPB5, 6, and 8, RNA subunit genes, iso­ (v) gene (Fridell et al.), 559-566 dicketal), 1623-1636 lation and characterization of Drosophila gypsy interaction (Spana E. coh, pseudo-templated transcrip­ (Woychik et al.), 313-323 rpob gene, E. coli, termination-altering and Corces), 1505-1515 tion (Jacques and Susskind) mutations (Landick et al.), Tyi transposition, specific terminal 1801-1810 1623-1636 structure required (Eichinger eukaryotic, common subunits of RRE RNA, interaction with HIV-1 Rev and Boeke), 324-330 (Woychiketal.), 313-323

2424 GENES & DEVELOPMENT protein (Olsen et al.), shorne and Agabian), Bacillus subtihs sigma* and sporula- 1357-1364 2121-2131 tion (Kimkel et al.), 525-535 rRNA transcription, and multiprotein Segment polarity gene, Diosophila M. xanthus, development-specific complex (Bell et al), 943-954 cP (Orenic et al.), 1053-1067 (Apelian and Inouye), Runt segmentation gene, Diosophila, en gene, control of stripes (Kassis), 1396-1403 sequence and distribution 433-443 Signal transduction systems, bacterial (Kania et al.), 1701-1713 Segmental identity, Diosophila, affected similarity to B. subtilis regula­ by exd gene (Peifer and Wies- tory gene (Weinrauch et al.), chaus), 1209-1223 860-872 Segmentation gene, Diosophila. See also Signal transduction S59 homeo box gene, Diosophila, ex­ specific genes cAMP-mediated (Weith et al.), pression in mesoderm, CNS, ftz, transcriptional activator of (Ueda 1437-1449 and midgut (Dohrmarm et al.), et al), 624-635 IFN-a system (Kessler et al.), 2098-2111 ftz stability mutants (Kellerman et 1753-1765 Saccharomyces ceievisiae. See also al.), 1936-1950 M. xanthus C-factor transmission re­ Yeast lunt sequence and distribution (Kania quires cell motility (Kim and CDC46 protein localization (Hen- etal.), 1701-1713 Kaiser), 896-904 nessy et al.), 2252-2263 Segmentation, chick hindbrain (Sundin mice, by transmembrane protein tyro­ genes (DlTl and DIT2) required for andEichele), 1267-1276 sine kinases (Reith et al.), spore wall formation (Briza et Sensory organ development, Diosophila 390-400 al.), 1775-1789 cut locus (Blocklinger et al.), yeast STEII protein kinase (Rhodes et HAP2/3/4 CCAAT transcriptional ac­ 1322-1331 al.), 1862-1874 tivation complex (Olesen and Sequence conservation, TFIID func­ Signaling peptides, mouse Wnt-l/int-1- Guarente), 1714-1729 tional domain, S. ceievisiae and related gene family (Gavin et human CKSl homologs (Richardson et S. pombe (Hoffmann et al.), al.), 2319-2332 al), 1332-1344 1141-1148 Site-specific recombination, Tn3 res/re- histone synthesis, balancing (Moran et Serendipity alpha (srya) gene, Dioso­ solvase (Bednarz et al.); al), 752-763 phila, role in blastoderm cellu- 2366-2375 mating response pathway, STEII gene larization (Schweisguth et al.), Skeletal muscle growth, and ski onco­ (Rhodes et al.), 1862-1874 922-931 gene (Sutrave et al.), 1462-1472 RPB5, 6 and 8 genes, encode RNA Senate gene, Diosophila EGF-con- ski oncogene, and skeletal muscle polymerase common subunits taining locus (Fleming et al.), growth (Sutrave et al.), (Woychik et al.), 313-323 2188-2201 1462-1472 STE12 overproduction and transcrip­ Serum, increased CCAAT-binding factor Slit protein, Diosophila midline glia de­ tional induction (Dolan and level (Dutta et al.), 243-254 velopment and axon pathways Fields), 492-502 Serum albumin gene, activation by (Rothenberg et al.), 2169-2187 TATA element replacement (Singer et C/EBP (Friedman and Sm proteins, interaction with snRNAs al.), 636-645 McKnight), 1416-1426 (Bordonne et al.), 1185-1196 TFIID functional domain conserved in Serum induction, of PRDII-BFl mRNA snRNA, base-pairing between U2 and S. pombe (Hoffmann et al.), (Fan and Maniatis), 29-42 U6 (Hausner et al.). 2146-2156 1141-1148 Serum response element (SRE), and c-/os snRNPs, S. ceievisiae, in vivo assembly Tyl transposition (Eichinger and transcriptional regulation (Ri­ (Bordonne et al.), 1185-1196 Boeke), 324-330 vera et al.), 255-268 Somites, developmental expression of Ul snRNA mutation (Liao et al.), Serum response factor (SRF) quail qmfl mRNA (de la 1766-1774 binding to human cardiac a-actin gene Brousse and Emerson), 567-581 U6 and U4 snRNA (Madhani et al), (Sartorelli et al), 1811-1822 Spl 2264-2277 CKIl enhances DNA binding of binding to human cardiac a-actin gene U6 snRNA gene expression (Brow and (Manak et al.), 955-967 (SartoreUi et al.), 1811-1822 Guthrie), 1345-1356 Sevenless gene, and Diosophila lough transcription fator, SV40 activation of Sarkosyl, RNA polymerase III initiation expression (Easier et al.), (Saffer et al.), 659-666 (Kovelman and Roeder), 728-739, (Kimmel et al.), SP60 spore coat protein, Dictyostehum, 646-658 712-727 cis-acting regulatory regions of Scabrous gene, Diosophila neurogenesis Sex determination, Diosophila (Haberstroh and Firtel), (Mlodzik et al.), 1848-1861 Diosophila dsx mutations and disrup­ 596-612 Schizosaccharomyces pombe tion of RNA processing (Na- Spec3 (S. puipuiatus] protein localiza­ sucl+ (Richardson et al.), 1332-1344 goshi and Baker), 89-110 tion, cilia and Golgi complexes TFIID functional domain, homology tra-2 gene (Mattox et al.), 789-805 of embryoriic ectoderm (Eldon to S. ceievisiae (Hoffmann et SF2 splicing factor, purification from etal.), 111-122 al.), 1141-1148 HeLa cells (Krainer et al.), Species selectivity, and rDNA transcrip­ Sea urchin. See also Stiongylocentiotus 1158-1171 tion (Pape et al.), 52-61 puipuiatus SH2 mutants, of c-src (Hirai and Spermatogenesis, expression of Zfy embryos, intersecting gene batteries Varmus), 2342-2352 genes (Nagamine et al.), 63-74 (Thiebaud et al.), 1999-2010 Sigma^^, E. coli, concentration regulated Spleen necrosis virus (SNV), distance-de­ TSAP, mammmalian homolog BSAP by heat shock proteins (Strauss pendent polyadenylation (Iwa- (Barberis et al.), 849-859 et al.), 2202-2209 saki and Temin), 2299-2307 Secondary structure, U2 RNA (Hart- Sigma factors Splice site selection, and alternative

GENES & DEVELOPMENT 2425 splicing of pre-mRNA (Nasim Stiongylocentiotus puipuiatus, Spec3 Tax gene, HTLV-1, mutants of (Smith etal.), 1172-1184 protein localization (Eldon et and Greene), 1875-1885 Spliceosome al.), 111-122 Temporal specificity, of globin gene ex- assembly, SF2 splicing factor (Krainer SunY intron, bacteriophage T4 (Mitchel pression, and HS sites etal.), 1158-1171 etal.), 777-788 (Behringer et al.), 380-389 snRNA base-pairing interactions Suppressible mutation (hcfl06), induced Termination elements, X laevis, ribo- (Hausner et al.), 2146-2156 by Robertson's Mutator in somal genes (McStay and Splicing maize (Martienssen et al.), Reeder), 1240-1251 apparatus, eukaryotic cells, and 331-343 Termination signal, phage X boxA snRNA (Ares and Igel), Suppression, of Diosophila veimilion (v) (Friedman et al.), 2210-2222 2132-2145 gene alleles (Fridell et al.), Testis determination, candidate Y genes Diosophila retrotransposon from exon 559-566 [Zfy-l and Zfy-2] expression in (Fridell et al.), 559-566 SV40 mice (Nagamine et al.), 63-74 factor, SF2, purification from HeLa activation of Spl (Saffer et al.), TFE3. See Transcription factor E3 cells (Krainer et al), 1158-1171 659-666 TFIIA, Xenopus, synthesis in somatic interaction with polyadenylation enhancer, repression by ElA gene cells vs oocytes (Kim et al.), (Niwaetal.), 1552-1559 products (Rochette-Egly et al.), 1602-1610 RNA-protein and protein-protein in­ 137-150 TFIID teractions (Bordonne et al.), large-T antigen and p53 binding (Lane S. ceievisiae, functional domain con­ 1185-1196 and Benchimol), 1-8 Review served in S. pombe (Hoffmann S. ceievisiae, multiple roles for U6 late promoter, binding of transcription etal.), 1141-1148 snRNA (Madhani et al.), factor LSF (Huang et al.), TATA-binding protein, involvement 2264-2277 287-298 in transcription from Ad IVa2 tians and cis systems (Hartshome and Symbiotic genes {R. meliloti), in planta, promoter (Carcamo et al), Agabian), 2121-2131 regulation of (Sharma and 1611-1622 Sporulation Signer), 344-356 TGAla, tobacco DNA-binding protein, Bacillus subtilis, and sigma^ tran­ Synergy between trans-activators (Tat and transcription activation scription factor (Kunkel et al.), and ElA), regulation of HlV-1 mechanism (Katagiri et al.), 525-535 gene expression (Laspia et al.), 1899-1909 role of B. subtilis regulatory gene 2397-2408 TGF-p family, secreted protein product product (Weinrauch et al.), encoded by Diosophila dpp 860-872 gene (St. Johnston et al.), S. cerevisiae, spore wall maturation 1114-1127 (Briza et al.), 1775-1789 T antigen, SV40, alteration of Spl ac­ Thymic development, TCR yb gene ex- Stage-specific embryonic antigen jSSEA- tivity at mRNA level (Saffer et pression (Carding et al.), 1), murine, cell-surface oligo­ al.), 659-666 1304-1315 saccharide (Kukowska-Latallo T cells, human, gene targeting at CD4 Thyroid hormone (TH) etal.), 1288-1303 locus (Jasin et al.), 157-166 receptor genes, correlation of expres­ STE12 yeast protein, overproduction T lymphocytes, activation (Fiering et sion with amphibian metamor­ yields increased transcription al.), 1823-1834 phosis (Yaoita and Brown), from pheromone-inducible TAR element, and Tat trans-activation 1917-1924 genes (Dolan and Fields), (Ratnasabapathy et al.), X. laevis, pancreatic gene regulation 492-502 2061-2074 (Shi and Brown), 1107-1113 STEII protein kinase, yeast, cell-type- TAR RNA sequence, HlV-1, Tat binding Thy-1/CD4 gene fusion, and homolo­ specific transcription and signal (Roy etal.), 1365-1373 gous recombination (Jasin et transduction (Rhodes et al.), TAT gene, transcription and cAMP- al.), 157-166 1862-1874 stimulated protein binding TIMP gene, mouse, developmental ex­ Stem cells, hematopoiesis in mice (Weith et al.), 1437-1449 pression (Flenniken and Wil­ (Jordan and Lemischka), Tat protein liams), 1094-1106 220-232 binding to HlV-1 TAR RNA (Roy et Tissue inhibitor of metalloproteins. See Stem cell differentiation, control by al.), 1365-1373 TIMP DIA/LIF (Rathjen et al.), trans-activation via TAR, HIV-l gene Tissue-specific expression, human car­ 2308-2318 expression (Ratnasabapathy et diac a-actin gene, requirements Stem-loop structure, snRNA (Ares and al.), 2061-2074 of (SartoreUi et al.), 1811-1822 Igel), 2132-2145 Tat trans-activator, regulation of HIV-l Tn3 res recombination site, resolvase Steroid hormone, ecdysone, and Dioso- gene expression (Laspia et al.), binding sites (Bednarz et al.), hila polytene chromosome 2397-2408 2366-2375 puffing (Segraves and Hogness), TATA box, TFIID (5. ceievisiae and S. Tobacco mosaic virus, 3'-untranslated 204-219 pombe] binding (Hoffmann et region (UTR) (Gallie and Steroid hormone receptor, Diosophila al.), 1141-1148 Walbot), 1149-1157 CFl transcription factor (Shea TATA element, yeast, replacement of Topoisomerase I, DNA, mutant alleles etal.), 1128-1140 and transcriptional initiation of (Morham and Shuman), Steroid receptor superfamily (Singer et al.), 636-645 515-524 and Diosophila E75 proteins (Segraves TATA motif, and TFIID-dependent tran­ Trans-acting factor GBF, and cAMP-in- and Hogness), 204-219 scription from AD IVa2 pro­ ducible Dictyostelium genes HNF-4 transcription factor (Sladek et moter (Carcamo et al.), (Hjorth et al.), 419-432 al), 2353-2365 1611-1622 Trans-activation

2426 GENES & DEVELOPMENT HTLV-1 Tax protein (Smith and mammmalian homolog (Bar- ergy (Laspia et al.), 2397-2408 Greene), 1875-1885 beris et al.), 849-859 Transcriptional induction, yeast, and HTLV-1 Tat-mediated (Roy et al.), concentration threshold required for STE12 overproduction (Dolan 1365-1373 transcription initiation (Fiering and Fields), 492-502 by NF-El multigene family (Yama- etal.), 1823-1834 Transcriptional regulation motoet al.), 1650-1662 Drosophila, CFl and CF2 bind to sl5 cAMP-mediated (Weith et al.), of serum albumin gene by C/EBP chorion promoter (Shea et al.), 1437-1449 (Friedman and McKnight), 1128-1140 Myb oncoprotein (Luscher and Ei- 1416-1426 HNF-4, novel steroid receptor family senmanj, 2235-2241 Review Trans-activator member (Sladek et al.), Transcriptional repression NRF-1, activation of nuclear respira­ 2353-2365 of C-/OS (Rivera et al.), 255-268 tory genes (Evans and Scar- mechanisms (Berk and Schmidt), by E2 trans-activator on BPV-1 PI pro­ puUa), 1023-1034 151-155 Meeting Review moter (Stenlund and Botchan), synergy between HIV-1 Tat and Ad NF-KB (Hagman et al.), 978-992 123-136 ElA (Laspia et al), 2397-2408 NF-KB, subunit interactions (Urban Transcriptional stimulation, in vitro, by Transcription and Baeuerle), 1975-1984 Drosophila UBX (Johnson and activation of human cardiac a-actin oct-1 binding to octamer sequence Krasnow), 1044-1052 gene (Sartorelli et al.), (Verrijzer et al.), 1964-1974 Transformation 1811-1822 PSEl of Ul snRNA promoter (Gun­ c-Jun and v-Jun (Bos et al.), 1677-1687 activation mechanism, plant activator derson et al.), 2048-2060 by SIC (Hirai and Varmus), 2342-2352 in human system (Katagiri et Spl, SV40 activation of (Saffer et al.), TiansfoTmeT-2 [tia-2] gene, Drosophila, al.), 1899-1909 659-666 alternative splicing (Mattox et balanced synthesis of histone locus SRF enhanced DNA binding (Manak al.), 789-805 (Moran et al), 752-763 et al.), 955-967 Transforming growth factor-p. See developmentally regulated, Droso- TFIIIC and TFIIIB (Brow and Guthrie), TGF-p phila Fos related AP-1 (Perkins 1341-1356 Transgenic Drosophila et al.), 822-834 tissue-specific expression of NF-El constructs, engrailed-lacZ (Hama et E3, binding specificity for (jiE3 site of multigene family (Yamamoto et al.), 1079-1093 IgH enhancer (Beckmann et al.), al.), 1650-1662 en/lacZ fusion genes, control of en 167-179 species specificity (Bell et al.), stripes (Kassis), 433-443 elongation, promoter-dependent block 943-954 Transgenic mice of c-myc (Spencer et al.), 75-88 Transcription initiation globin (human), gene switching in gal operon (£. coli], repression of and RNA polymerase III, mhibition by (Behringer et al.), 380-389 DNA looping (Mandal et al.), Sarkosyl (Kovelman and human a-globin genes and regulatory 410-418 Roeder), 646-658 region (Higgs et al.), 1588-1601 HeLa LSF, binds two SV40 sites TFIID, S. cerevisiae and S. pombe se­ and insulin function (Keller et al.), (Huang et al.), 287-298 quence conservation (Hoffmann 1316-1321 HNF-1, broadly acting homeo domain etal), 1141-1148 ski expression and skeletal muscle protein (Baumhueter et al.), Transcription termination (Sutrave et al), 1462-1472 372-379 mechanism of in X. laevis (Labhart TIMP-iacZ fusion gene (Flenniken initiation, functional downstream and Reeder), 269-276 and Williams), 1094-1106 TATA motif (Carcamo et al.), RNA polymerase I, terminator-pro­ Translation 1611-1622 moter interaction (McStay and cap-independent translation of EMCV in vitro initiation, of Ul snRNA Reeder), 1240-1251 (Jang and Wimmer), 1560-1572 (Gunderson et al.), 2048-2060 Transcriptional activation E. coli, initiator tRNA, initiation keratinocyte-specific gene expression complex, yeast HAP2/3/4 CCAAT codon, and IF3 (Hartz et al.), (Leask et al), 1985-1998 (Olesen and Guarente), 1790-1800 from LTR of RSV (Dutta et al.), 1714-1729 Translational activation, masked ma- 243-254 byLAP(Descombesetal.), 1541-1551 temal mRNA (Standart et al.), pseudo-templated, by E. coli RNA by pseudorabies virus IE protein 2157-2168 polymerase (Jacques and Suss- (Martin et al.), 2376-2382 Translational efficiency, and nonpolya- kind), 1801-1810 and TATA element replacement denylated mRNAs (Gallic and role of RNA polymerase subunits (Singer et al.), 636-645 Walbot), 1149-1157 (Woychik et al.), 313-323 threshold event (Fiering et al.), Translational regulation termination and antitermination, 1823-1834 poly(A) removal during Xenopus oo­ phage X. (Friedman et al.), Transcriptional activator cyte maturation (Fox and 2210-2222 erythroid factor GF-1 (NF-El/Eryf 1) Wickens), 2287-2298 termination and pausing, altered by (Martin and Orkin), 1886-1898 poly(A) removal during Xenopus oo­ mutations in E. coli rpob gene ets-l (Gunther et al.), 667-679 cyte maturation (Varnum and (Landick et al), 1623-1636 multimeric, ISGF3 (Kessler et al.), Wormington), 2278-2286 Transcription factors. See also indi­ 1753-1765 Transmembrane receptor c-kit (W mu­ vidual names Transcriptional control, cell-specific reg­ tant mice), point mutations in Transcription factor ulation of HNF-3A (Lai et al.), kinase domains of (Reith et al.), AP-4 dimerization domains (Hu et al.), 1427-1436 390-400 Transposable element, DNA modifica­ 1741-1752 Transcriptional elongation, stabilization tion of Mu in maize (Mar- B-cell lineage-specific (BSAP), TSAP causes HlV-l Tat-Ad ElA syn­

GENES & DEVELOPMENT 2427 tienssen et al.), 331-343 ([ohnson and Krasnow), metamorphosis and thyroid hormone Transposition, of yeast Tyl retrotran- 1044-1052 receptor gene expression sposon (Eichinger and Boeke), Ultiabithorax [Ubx], Diosophila, simi­ (Yaoita and Brown), 1917-1924 324-330 larity to abdA (Karch et al.), oocytes, deadenylation of maternal Transposon fusions, Tn5-gusA pro­ 1573-1587 mRNAs (Fox and Wickens), moter/probe construct and R. USF regulatory protein, c-myc-related 2287-2298 meliloti gene regulation with helix-loop-helix domain pancreatic gene regulation (Shi and (Sharma and Signer), 344-356 (Gregor et al.), 1730-1740 Brown), 1107-1113 Transposon mutagenesis. Antirrhinum Ustilago maydis, plant pathogen, b primary axis formation, RA-sensitive majus floral development (Car­ locus multiallelic recombina­ period (Sive et al.), 932-942 penter and Coen), 1483-1493 tion (Kronstad and Leong), ribosomal genes, transcription termi­ Transthyretin (TTR) gene, and HNF-4- 1384-1395 nation mechanism (Labhart and binding activity (Sladek et al.), Reeder), 269-276 2353-2365 RNA polymerase I, terminator-pro­ tRNA, E. coli translation initiation moter interaction (McStay and (Hartz et al.), 1790-1800 v-erbA oncogene, phosphorylation of Reeder), 1240-1251 Trypanosomatids, secondary structure protein required for function TFIIIA synthesis, somatic cells and of U2 RNAs (Hartshome and (Glineur et al.), 1663-1676 oocytes (Kim et al.), 1602-1610 Agabian), 2121-2131 v-Jun, as compared to c-Jun in inducing Trypanosome, VSG genes, ordered ex­ cell transformation (Bos et al.), pression of (Thon et al.), 1677-1687 X-linked gene, human PGK-1, CpG is­ 1374-1383 v-src, increase CCAAT-binding factor land (Pfeifer et al.), 1277-1287 Trypsin, X. laevis, developmental and level (Dutta et al.), 243-254 thyroxine-dependent regulation VAi adenovirus gene, ElA-mediated of (Shi and Brown), 1107-1113 transcriptional initiation (Ko- Tyrosine kinase c-ldt, point mutations velman and Roeder), 646-658 Yeast, PRTF/GRM, purification and in W mice (Reith et al.), Vaccinia topoisomerase, genetic screen cloning (Ammerer), 299-312. 390-400 for mutants (Morham and See also Saccharomyces cerevi­ Tyrosine hydroxylase (TH) gene, regula­ Shuman), 515-524 siae tion of by nerve growth factor Variable surface glycoproteins (VSGs), Yolk protein genes (ypl and yp2), Droso- (NGF) (Gizang-Ginsberg and Trypanosome, ordered expres­ phila, ovarian enhancers of Ziff), 477-491 sion of (Thon et al.), 1374-1383 (Logan and Wensink), 613-623 T-cell receptor (TCR), 78 gene expres­ Vasa maternal-effect gene, posterior lo­ sion (Carding et al.), 1304-1315 calization (Lasko and Ash- bumer), 905-921 Zfy genes, candidate testis-determining U Virus induction, of PRDII-BFl mRNA Y genes, expression in mice Ul snRNA promoter, in vitro transcrip­ (Fan and Maniatis), 29-42 (Nagamine et al.), 63-74 tion initiation (Gunderson et Vulval development, C. elegans Un-lO Zinc finger domain al.), 2048-2060 gene (Kim and Horvitz), steroid receptor superfamily (Sladek et Ul snRNA sequences, yeast, contribu­ 357-371 al.), 2353-2365 tion to Ul snRNP function Tax protein, nuclear localization (Liaoetal.), 1766-1774 (Smith and Greene), 1875-1885 W U2 RNA, secondary structure (Hart- Zinc finger motifs, of PRDII-BFl DNA shorne and Agabian), W locus (mice), and c-kit point mutation binding protein (Fan and Man- 2121-2131 (Reith et al.), 390-400 iaris), 29-42 U2 snRNA, stem-loop structures (Ares Wnt-l/int-l-related gene family, fetal Zinc finger protein and Igel), 2132-2145 and adult mouse development C2H2 family, Diosophila CF2 tran­ U4 snRNA, S. cerevisiae, association (Gavin etal.), 2319-2332 scription factor (Shea et al.), with U6 snRNA (Madhani et 1128-1140 al.), 2264-2277 DNA bending and binding specificity U6 snRNA gene expression, B block pro- (Spana and Corces), 1505-1515 moter element (Brow and Diosophila segmentation ci'^ protein Guthrie), 1345-1356 Xenopus laevis sequence similarity (Orenic et U6 snRNA, S. cerevisiac,multiple roles deadenylation of maternal mRNAs aL), 1053-1067 of (Madhani et al.), 2264-2277 (Varnum and Wormington), encoded by testis determining Zfy-1 UASQ (GAL upstream activating se­ 2278-2286 and Zfy-2 genes (Nagamine et quence), chromatin structure of dominant-negative mutant of PDGF aL), 63-74 influenced by GRF2 yeast pro­ gene (Mercola et al.), TFEA synthesis in Xenopus (Kim et tein (Chasman et al.), 503-514 2333-2341 aL), 1602-1610 UBF-SLl complexes, and rRNA pro­ homeo box gene activation (Cho and Zygotic genes, Drosophila en gene, con­ moter selectivity (Bell et al.), Robertis), 1910-1916 trol of stripes (Kassis), 433-443 943-954 homeo box Xlhbox2 mRNA stability Zygotic dorsoventral genes, Rho, and UBX protein, Diosophila, transcrip­ (Brown and Richard), Drosophila neural development tional stimulation in vitro 1925-1935 (Bier et al.), 190-203

2428 GENES & DEVELOPMENT Cold Spring Harbor Laboratory 1991 Meeting Schedule THE ROLE OF ISOFORM DIVERSITY IN CYTOSKELETAL FUNCTIONS, AprU 24 - 28 Henry Epstein, Baylor College of Medicine Donald Fischman, Cornell University David Helfman, Cold Spring Harbor Laboratory STRESS PROTEINS & THE HEAT SHOCK RESPONSE April 29 - May 2 Costa Georgopoulos, University of Utah Richnrd Morimoto, Northwestern University GENOME MAPPING & SEQUENCING, May 8 -12 Charles Cantor, DOE, Human Genome Project Maynard Olson, Washington University School of Medicine Richard Roberts, Cold Spring Harbor Laboratory RNA PROCESSING, May 15 -19 Chris Greer, University of California, Irvine James Manley, Columbia University Alan Weiner, Yale University School of Medicine RNA TUMOR VIRUSES, May 21 - 26 John Coffin, Tufts University School of Medicine Irvin Chen, University of California, Los Angeles SYMPOSIUM: THE CELL CYCLE, May 29 - June 5 David Beach, Cold Spring Harbor Laboratory Bruce Stillman, Cold Spring Harbor Laboratory James D. Watson, Cold Spring Harbor Laboratory YEAST CELL BIOLOGY, August 14 -18 John Pringle, University of Michigan Steven Reed, Scripps Clinic & Research Foundation MOLECULAR GENETICS OF BACTERIA & PHAGES August 20 • 25 Susan Gottesman, National Institutes of Health, NIH Lucia Rothman-Denes, University of Chicago Mimi Susskind, University of Southern California REGULATION OF EUKARYOTIC mRNA TRANSCRIPTION August 28 - September 1 Winship Herr, Cold Spring Harbor Laboratory Robert Tjian, University of California, Berkeley Keith Yamamoto, University of California, San Francisco EUKARYOTIC DNA REPUCATION, September 4 - 8 Thomas Kelly, Johns Hopkins University Bruce Stillman, Cold Spring Harbor Laboratory SYNTHESIS OF RIBOSOMES, September 11-15 Lasse Lindahl, University of Rochester Edward Morgan, Roswell Park Memorial Institute Robert Perry, Fox Chase Cancer Center Barbara Sollner-Webb, Johns Hopkins University Jonathan Warner, Albert Einstein College of Medicine MODERN APPROACHES TO NEW VACCINES INCLUDING PREVENTION OF AIDS, September 19 - 23 Frederick Brown, University of Surrey Robert Chanock, National Institutes of Health, NIAID Harold Ginsberg, Columbia University College ofP&S Richard Lemer, Research Institute of Scripps Clinic MOLECULAR NEUROBIOLOGY OF DROSOPHILA September 25 - 29 Ralph Greenspan, Roche Institute of Molecular Biology John Palka, University of Washington MOLECULAR BIOLOGY OF SIGNAL TRANSDUCTION IN PLANTS, October 2 - 6 Frederick Ausubel, Whitehead Institute Nam-Hai Chua, The Rockefeller University Gerald Fink, Whitehead Institute Venkatesan Sundaresan, Cold Spring Harbor Laboratory FOR INFORMATION AND APPUCATIONS WRITE TO: ^%"»o '% MEETINGS OFFICE r-c\ \ COLD SPRING HARBOR LABORATORY Lbrljj COLD SPRING HARBOR, NY 11724 ^EN^i^''^ 516-367-834€ FAX-516-367-8846

Reader Service No. 529 Now available from ICN Biomedicals, Inc., Chloramphenicol, D-threo-[1.2-''^C] for monitoring promoter activity in promoter CAT fusion.

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