LAT2 Monoclonal Antibody, Clone NAP-07 (PE)

LAT2 monoclonal antibody, clone NAP-07 (PE)

Catalog # : MAB4522 規格 : [ 100 ug ] List All

Specification Application Image

Product Mouse monoclonal antibody raised against partial recombinant LAT2. Western Blot Description: Immunocytochemistry

Immunogen: Recombinant protein corresponding to partial human LAT2. Immunoprecipitation Flow Cytometry Host: Mouse

Theoretical MW 25-30 (kDa):

Reactivity: Human, Mouse

Specificity: This antibody reacts with Non-T cell activation linker (NTAL), also known as LAB (linker of activated B cells), a 25-30 KDa transmembrane adaptor protein present in membrane microdomains (rafts) of B lymphocytes, NK cells and myeloid cells.

Form: Liquid

Conjugation: PE

Concentration: 0.1 mg/mL

Isotype: IgG1

Recommend Flow Cytometry (1:30) Usage: The optimal working dilution should be determined by the end user.

Storage Buffer: In PBS (0.2% BSA, 0.09% sodium azide)

Storage Store in the dark at 4°C. Do not freeze. Instruction: Avoid prolonged exposure to light. Aliquot to avoid repeated freezing and thawing.

Note: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Datasheet: Download

Publication Reference 1. Topography of signaling molecules as detected by electron microscopy on plasma membrane sheets isolated from non-adherent mast cells. Lebduska P, Korb J, Tumova M, Heneberg P, Draber P.J Immunol Methods. 2007 Dec 1;328(1-2):139-51. Epub 2007 Sep 18. 2. Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL. Volna P, Lebduska P, Draberova L, Simova S, Heneberg P, Boubelik M, Bugajev V, Malissen B, Wilson BS, Horejsi V, Malissen M, Draber P.J Exp Med. 2004 Oct 18;200(8):1001-13. Epub 2004 Oct 11. 3. NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation. Tkaczyk C, Horejsi V, Iwaki S, Draber P, Samelson LE, Satterthwaite AB, Nahm DH, Page 1 of 2 2017/2/16 Metcalfe DD, Gilfillan AM.Blood. 2004 Jul 1;104(1):207-14. Epub 2004 Mar 9.

Applications Western Blot

Immunocytochemistry

Immunoprecipitation

Flow Cytometry

Gene Information

Entrez GeneID: 7462

Gene Name: LAT2

Gene Alias: HSPC046,LAB,NTAL,WBSCR15,WBSCR5,WSCR5

Gene linker for activation of T cells family, member 2 Description:

Omim ID: 605719

Gene Ontology: Hyperlink

Gene Summary: This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq

Other OTTHUMP00000160648,OTTHUMP00000179118,OTTHUMP00000179 Designations: 119,Williams-Beuren syndrome chromosome region 15,Williams-Beuren syndrome chromosome region 5,linker for activation of B cells,linker for activation of T cells family member 2,non-T cell activation lin

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