LAT2 Monoclonal Antibody, Clone NAP-07 (PE)

LAT2 monoclonal antibody, clone Storage Instruction: Store in the dark at 4°C. Do not NAP-07 (PE) freeze. Avoid prolonged exposure to light. Catalog Number: MAB4522 Aliquot to avoid repeated freezing and thawing.

Regulatory Status: For research use only (RUO) Entrez GeneID: 7462

Product Description: Mouse monoclonal antibody Gene Symbol: LAT2 raised against partial recombinant LAT2. Gene Alias: HSPC046, LAB, NTAL, WBSCR15, Clone Name: NAP-07 WBSCR5, WSCR5

Immunogen: Recombinant protein corresponding to Gene Summary: This gene is one of the contiguous partial human LAT2. genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This Host: Mouse gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the Theoretical MW (kDa): 25-30 same protein. [provided by RefSeq]

Reactivity: Human,Mouse References: 1. Topography of signaling molecules as detected by Applications: Flow Cyt, ICC, IP, WB electron microscopy on plasma membrane sheets (See our web site product page for detailed applications isolated from non-adherent mast cells. Lebduska P, Korb information) J, Tumova M, Heneberg P, Draber P. J Immunol Methods. 2007 Dec 1;328(1-2):139-51. Epub 2007 Sep Protocols: See our web site at 18. http://www.abnova.com/support/protocols.asp or product 2. Negative regulation of mast cell signaling and function page for detailed protocols by the adaptor LAB/NTAL. Volna P, Lebduska P, Draberova L, Simova S, Heneberg P, Boubelik M, Specificity: This antibody reacts with Non-T cell Bugajev V, Malissen B, Wilson BS, Horejsi V, Malissen activation linker (NTAL), also known as LAB (linker of M, Draber P. J Exp Med. 2004 Oct 18;200(8):1001-13. activated B cells), a 25-30 KDa transmembrane adaptor Epub 2004 Oct 11. protein present in membrane microdomains (rafts) of B 3. NTAL phosphorylation is a pivotal link between the lymphocytes, NK cells and myeloid cells. signaling cascades leading to human mast cell Form: Liquid degranulation following Kit activation and Fc epsilon RI aggregation. Tkaczyk C, Horejsi V, Iwaki S, Draber P, Conjugation: PE Samelson LE, Satterthwaite AB, Nahm DH, Metcalfe DD, Gilfillan AM. Blood. 2004 Jul 1;104(1):207-14. Epub Concentration: 0.1 mg/mL 2004 Mar 9.

Isotype: IgG1

Recommend Usage: Flow Cytometry (1:30) The optimal working dilution should be determined by the end user.

Storage Buffer: In PBS (0.2% BSA, 0.09% sodium azide)

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