1 2004-2005 First Year Review (only Principles drugs have been updated; doesn’t include Derm)
2 Abciximab Antiplatelet Anti-GPIIb/IIIa receptor antibody
3 Acetaminophen Analgesic, Antipyretic
4 Adalimumab TNF inhibitor Anti-TNF antibody Used in rheumatoid arthritis
5 Adrenocorticotropin (ACTH) Anterior pituitary hormone Anticonvulsant Stimulates synthesis and release of cortisol
6 Alemtuzumab Antineoplastic Anti-CD52 antibody
7 Alfentanil Opioid General anaesthetic Intravenous anaesthetic
8 Allopurinol Antigout Antineoplastic (supporting agent) Folic acid analogue Xanthine oxidase inhibitor
9 Amantadine Antiviral Antiparkinson Treatment of Influenza A Inhibits replication at the stage of uncoating Inhibits dopamine release
1 10 Amikacin Aminoglycoside antibiotic Bactericidal protein synthesis inhibitor 30S ribosome Freezes initiation
11 Aminocaproic acid (EACA) Procoagulant Inhibitor of plasminogen activation (decreases fibrinolysis)
12 Aminoglutethimide Antineoplastic Immunosuppressive Glucocorticoid antagonist Aromatase inhibitor (decreases steroid synthesis)
13 Aminoglycosides Antibiotics Bactericidal protein synthesis inhibitors 30S ribosome Freeze initiation
14 Amitriptyline Tricyclic antidepressant (TCA)
15 Amoxicillin Penicillin antibiotic Cell wall synthesis inhibitor Antiulcer Amino penicillin Inhibits peptidoglycan cross-linking
16 Amphetamine Indirect sympathomimetic Drug of abuse ADD treatment Stimulant
17 Ampicillin Penicillin antibiotic Cell wall synthesis inhibitor Amino penicillin Inhibits peptidoglycan cross-linking
18 Amsacrine
2 Antineoplastic Miscellaneous
19 Angiostatin Antineoplastic Angiogenesis inhibitor
20 Anistreplase Thrombolytic Streptokinase + plasminogen
21 Anti-thymocyte globulin Immunosuppressive Anti-T cell antibody
22 Aprotinin Procoagulant Fibrinolytic inhibitor Serine protease inhibitor (“serpin”) Streptokinase inhibitor
23 Argatroban Anticoagulant Direct thrombin inhibitor
24 L-asparaginase Antineoplastic Protein synthesis inhibitor
25 Aspirin (Acetylsalicylic acid, ASA) NSAID (acetylsalicylate) Analgesic, Anti-inflammatory Antipyretic, Antiplatelet Irreversible cyclooxygenase inhibitor
26 Atropine Anticholinergic Antimuscarinic Treatment for bradycardia, diarrhea, cholinesterase poisoning
27 Azathioprine Immunosuppressive Antineoplastic Antimetabolite (“pseudofeedback inhibition” of HGPRT and PRP)
3 28 Azithromycin Macrolide antibiotic Bacteriostatic protein synthesis inhibitor 50S ribosome Inhibits translocation
29 Aztreonam New β lactam antibiotic Monobactam
30 Baclofen Skeletal muscle relaxant Anxiolytic
GABAB agonist 31 Bacitracin Antibiotic Cell wall synthesis inhibitor Topical, not a β lactam, Inhibits dephosphorylation of bactoprenol
32 Basiliximab Immunosuppressive Anti-CD25 (interleukin 2 receptor) Organ transplant (antirejection)
33 Benzathine penicillin G Penicillin antibiotic Cell wall synthesis inhibitor Inhibits peptidoglycan cross-linking Repository preparation
34 Benztropine Anticholinergic Antiparkinson Muscarinic receptor antagonist
35 Betamethasone Adrenocorticosteroid Glucocorticoid Anti-inflammatory steroid Not by inhalation
36 Bethanecol Cholinomimetic Muscarinic agonist Induces defecation and urination
4 Bronchoconstrictor
37 Bleomycin Antineoplastic Natural product Antibiotic
38 Bivalirudin Anticoagulant Direct thrombin inhibitor
39 Bortezomib Antineoplastic Proteosome inhibitor
40 Bradykinin Inflammatory mediator Plasma, hypotension, pain
41 Bromocriptine Antiparkinson
Dopamine (D2) agonist Inhibits prolactin release
42 Brupropion Second generation antidepressant
43 Buprenorphine Opioid Partial agonist
44 Buspirone Sedative/hypnotic Anxiolytic
45 Busulfan Antineoplastic Alkylating agent
46 Butorphanol Opioid Analgesic µ receptor partial agonist or antagonist
47 C3a, C5a
5 Inflammatory mediators Anaphylatoxins Low molecular weight complement cleavage products
48 Carbamazepine Anticonvulsant
49 Carbenicillin Penicillin antibiotic Cell wall synthesis inhibitor Anti-pseudomonal penicillin Inhibits peptidoglycan cross-linking
50 Carbidopa Antiparkinson Peripheral dopa decarboxylase inhibitor
51 Carmustine (BCNU) Antineoplastic Alkylating Agent Nitrosourea
52 Cefaclor Cephalosporin antibiotic Cell wall synthesis inhibitor 2nd generation Oral
53 Cefadroxil Cephalosporin antibiotic Cell wall synthesis inhibitor 1st generation Oral
54 Cefepime Cephalosporin antibiotic Cell wall synthesis inhibitor 4th generation CSF penetration
55 Cefotaxime Cephalosporin antibiotic Cell wall synthesis inhibitor 3rd generation CSF penetration
56 Cefoxitin
6 Cephalosporin antibiotic Cell wall synthesis inhibitor 2nd generation
57 Ceftazidime Cephalosporin antibiotic Cell wall synthesis inhibitor 3rd generation
58 Ceftriaxone Cephalosporin antibiotic Cell wall synthesis inhibitor 3rd generation CSF penetration
59 Cefuroxime Cephalosporin antibiotic Cell wall synthesis inhibitor 2nd generation CSF penetration
60 Celecoxib NSAID Anti-inflammatory Cyclooxygenase 2 (COX-2) inhibitor
61 Cephalexin Cephalosporin antibiotic Cell wall synthesis inhibitor 1st generation Oral
62 Cephalosporins Antibiotics β lactam Cell wall synthesis inhibitors Inhibit cross-linking of peptidoglycan
63 Cephalothin Cephalosporin antibiotic Cell wall synthesis inhibitor 1st generation Oral
64 Cetirizine Antihistamine
H1 antagonist
7 Non-sedating
65 Chloral hydrate Sedative/Hypnotic General anaesthetic
Acts on GABAA receptor complex Similar to barbiturates
66 Chloramphenicol Antibiotic Bacteriostatic protein synthesis inhibitor 50S ribosome Inhibits peptide bond formation
67 Chlordiazepoxide Sedative/hypnotic Anxiolytic Benodiazepine
Acts on GABAA receptor complex 68 Chlorpheniramine Classical antihistamine
H1 antagonist 69 Chlorpromazine Antipsychotic Phenothiazine
70 Ciprofloxacin Fluoroquinolone antibiotic DNA replication inhibitor Inhibits bacterial DNA gyrase
71 Cisplatin Antineoplastic Miscellaneous Cross-linking agent
72 Clarithromycin Macrolide antibiotic Bacteriostatic protein synthesis inhibitor Antiulcer 50S ribosome Inhibits translocation
73 Clavulanic acid β-lactamase inhibitor
8 Combined with antibacterials
74 Clindamycin Antibiotic Bacteriostatic protein synthesis inhibitor 50S ribosome Anaerobic infections
75 Clopidogrel Antiplatelet ADP receptor antagonist
76 Cloxacillin Penicillin antibiotic Cell wall synthesis inhibitor Penicillinase resistant penicillin Inhibits peptidoglycan cross-linking
77 Clozapine Antipsychotic
78 Cobalamin (cyanocobalamin, hydroxocobalamin) Vitamin Treatment for vitamin B12 deficiency
79 Cocaine Indirect sympathomimetic Drug of abuse Topical anaesthetic Stimulant Local anaesthetic
80 Codeine Opioid Analgesic Weak agonist
81 Cortisol (Hydrocortisone) Adrenocorticosteroid Glucocorticoid Anti-inflammatory steroid
82 Cyclophosphamide
9 Antineoplastic Alkylating Agent Nitrogen mustard
83 Cycloserine Antibiotic Cell wall synthesis inhibitor Secondary TB drug Inhibits formation of Park nucleotide
84 Cyclosporine Immunosuppressive Antineoplastic Binds cyclophilin Inhibits calcineurin
85 Cytarabine (AraC) Antineoplastic Antimetabolite
86 Dacarbazine Antineoplastic Alkylating Agent
87 Daclizumab Immunosuppressive Anti-CD25 (interleukin 2 receptor) antibody Organ transplant (anti-rejection)
88 Dactinomycin Antineoplastic Natural product Antibiotic
89 Dalteparin Anticoagulant LMW Heparin ATIII activator
90 Dantrolene Skeletal muscle relaxant Ryanodine receptor antagonist Treatment for malignant hyperthermia
91 Dapsone Sulfone antibiotic Nucleic acid and
10 protein synthesis inhibitor Inhibits dihydropteroate synthetase Leprosy
92 Daunorubicin Antineoplastic Anthracycline antibiotic Natural product
93 Deprenyl/selegiline Antiparkinson Monoamine oxidase B inhibitor (MAO-I) Potentiates effects of L-Dopa
94 Desipramine Tricyclic antidepressant (TCA)
95 Desmopressin acetate Synthetic analogue of arginine vasopressin Used in treatment of bleeding disorders
96 Dexamethasone Adrenocorticosteroid Glucocorticoid Antineoplastic Antiemetic Anti-inflammatory steroid Not by inhalation
97 Dextromethorphan Opioid Antitussive
98 Diazepam Sedative/hypnotic Anxiolytic Anticonvulsant Benzodiazepine
Acts on GABAA receptor complex 99 Diflunisal NSAID Analgesic, Anti-inflammatory Antipyretic Cyclooxygenase inhibitor
100 Diphenhydramine
11 Classical antihistamine Antiemetic
H1 antagonist 101 Diphenoxylate docusate Antidiarrheal Opiate
102 Dipyridamole Antiplatelet Phosphodiesterase inhibitor (increases cAMP)
103 Doxorubicin Antineoplastic Anthracycline antibiotic Natural product
104 Doxycycline Tetracycline antibiotic Bacteriostatic protein synthesis inhibitor 30S ribosome Prevents aminoacyl tRNA attachment
105 Drotrecogin alfa (Activated Protein C) Anticoagulant Many actions Treatment for septic shock
106 Edrecolomab Antineoplastic Anti-17-1A antibody
107 Enflurane General anaesthetic Inhaled anaesthetic
108 Enoxaparin Anticoagulant LMW Heparin ATIII activator
109 Entacapone Antiparkinson Peripheral catechol-o-methyltransferase inhibitor
12 110 Ephedra (Ma Huang) Dietary supplement Amphetamine-like stimulant
111 Eptifibatide Antiplatelet GPIIb/IIIa antagonist
112 Erythromycin Macrolide antibiotic Bacteriostatic protein synthesis inhibitor 50S ribosome Inhibits translocation
113 Erythropoietin (EPO) Cytokine Primary regulator of RBC synthesis
114 Etanercept TNF inhibitor Tumor necrosis factor receptor
+ Fc portion of IgG Used in rheumatoid arthritis
115 Ethanol Drug of abuse Sedative
116 Ethosuximide Anticonvulsant
117 Etomidate General anaesthetic Intravenous anaesthetic
118 Etoposide Antineoplastic Natural product Plant alkaloid
119 Fentanyl Opioid Analgesic µ receptor agonist
13 120 Fexofenadine Antihistamine
H1 antagonist Non-sedating
121 Flumazenil Benzodiazepine antagonist
Acts on GABAA receptor complex 122 5-Fluorouracil Antineoplastic Antimetabolite Thymidylate synthase inhibitor
123 Fluoxetine Antidepressant Selective serotonin reuptake inhibitor (SSRI)
124 Flurazepam Sedative/Hypnotic Benzodiazepine
Acts on GABAA receptor complex 125 Fluorinated Quinolones ciprofloxacin, norfloxacin Antibiotics DNA replication inhibitors Inhibit bacterial DNA gyrase
126 Folic acid Vitamin Treatment for folic acid deficiency
127 Gefitinib Antineoplastic Miscellaneous Tyrosine kinase inhibitor
128 Gemcitabine Antineoplastic Antimetabolite
129 Gemtuzumab Antineoplastic
14 Anti-CD33 antibody
130 Gentamicin Aminoglycoside antibiotic Bactericidal protein synthesis inhibitor 30S ribosome Freezes initiation
131 Ginko biloba Dietary supplement Treatment of Alzheimer symptoms
132 Glutethimide Sedative/Hypnotic
133 Haloperidol Antipsychotic
134 Halothane General anaesthetic Inhaled anaesthetic
135 Heparin Anticoagulant ATIII activator
136 Heroin Drug of abuse Opioid
137 Hirudin Anticoagulant Direct thrombin inhibitor (DTI)
138 Histamine Inflammatory mediator Stored in mast cells and basophils
139 Hydrocortisone Adrenocorticosteroid Glucocorticoid Anti-inflammatory steroid
140 4-Hydroxycoumarin Oral anticoagulant
15 Vitamin K synthesis inhibitor
141 Hydroxyurea Antineoplastic Miscellaneous Ribonucleotide reductase inhibitor
142 Hydroxyzine Classical antihistamine
H1 antagonist 143 Ibritumomab Antineoplastic Anti-CD20 antibody
144 Ibuprofen NSAID Analgesic, Anti-inflammatory Antipyretic Reversible cyclooxygenase inhibitor
145 Imatinib Antineoplastic Miscellaneous Tyrosine kinase inhibitor
146 Imipenem/Cilastatin New β lactam antibiotic Cilastatin inhibits a kidney dipeptidase that inactivates imipenem
147 Imipramine Indirect sympathomimetic Tricyclic antidepressant (TCA) Antimicturant
148 Indomethacin NSAID Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitor Tocolytic Uterine relaxant
149 Infliximab TNF inhibitor Anti-TNF monoclonal antibody Treatment of IBD
16 150 Interferon alpha Antiviral for hepatitis Antineoplastic Cytokine Anti-angiogenesis
151 Interleukin 2 Cytokine Antineoplastic
152 Interleukin 11 Cytokine Antineoplastic (supporting agent)
153 Interleukin 12 Cytokine Antineoplastic (supporting agent)
154 Irinotecan Antineoplastic Natural product
155 Isoflurane General anaesthetic Inhaled anaesthetic
156 Kallidin Inflammatory mediator Plasma, hypotension, pain
157 Kava kava Dietary supplement Stress relief and treatment of insomnia
158 Ketamine General anaesthetic Drug of abuse Sedative
159 Ketoprofen NSAID Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitor
17 160 Lepirudin Anticoagulant Direct thrombin inhibitor (DTI)
161 Levodopa Antiparkinson Dopamine precursor
162 Leucovorin Antineoplastic (supporting agent) Folic acid analogue (used in methotrexate rescue)
163 Leukotriene B4 (LTB4) Inflammatory mediator Lipoxygenase product of arachidonate metabolism Chemotactic
164 Leukotrienes C4, D4, E4
(LTC4,LTD4,LTE4) Inflammatory mediators Cysteinyl leukotrienes Peptidyl leukotrienes SRS-A Lipoxygenase products of arachidonate metabolism
165 Lidocaine Class I antiarrhythmic Local anaesthetic Na+ channel blocker (activated and inactivated channels)
166 Linezolid Oxazolidinone antibiotic Protein synthesis inhibitor 50S ribosomal subunit
167 Lithium Antidepressant Used to treat manic/depressive disorder
168 Lomustine (CCNU) Antineoplastic
18 Alkylating Agent Nitrosourea
169 Loperamide Antidiarrheal Opiate
170 Loratidine Antihistamine
H1 antagonist Non-sedating
171 Lorazepam Anxiolytic Anticonvulsant Benzodiazepine
Acts on GABAA receptor complex 172 Lysergic acid diethylamide (LSD) Drug of abuse Hallucinogen
173 Macrolides erythromycin, azithromycin, clarithromycin Antibiotics Bacteriostatic protein synthesis inhibitors 50S ribosome
174 Marijuana Drug of abuse Cannabinoid
175 Mechlorethamine Antineoplastic Alkylating Agent Nitrogen mustard
176 Meclofenamate NSAID Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitor
177 Melphalan Antineoplastic Alkylating Agent
19 Nitrogen mustard
178 Meperidine Opioid analgesic µ receptor agonist
179 Mepivacaine Local anaesthetic
180 Meprobamate Sedative/hypnotic Anxiolytic
181 6-Mercaptopurine Antineoplastic Antimetabolite (“pseudofeedback inhibition” of HGPRT and PRP – purine synthesis)
182 Mesna Antineoplastic (supporting agent) Prevent hemorrhagic cystitis due to cyclophosphamide
183 Methicillin Penicillin antibiotic Cell wall synthesis inhibitor Pencillinase resistant penicillin Inhibits peptidoglycan cross-linking
184 Methotrexate Immunosuppressive Antineoplastic Folic acid antagonist Dihydrofolate reductase inhibitor
185 Methylprednisolone Adrenocorticosteroid Glucocorticoid Anti-inflammatory steroid Not by inhalation
186 Metronidazole Antibiotic Antiparasitic Antiulcer Anaerobes Reduction leads to intermediates
20 that damage DNA
187 Minocycline Tetracycline antibiotic Bacteriostatic protein synthesis inhibitor 30S ribosome Prevents aminoacyl tRNA attachment
188 Mitomycin C Antineoplastic Natural product Antibiotic
189 Metamphetamine Drug of abuse Stimulant
190 Methadone Opioid µ receptor agonist
191 Montelukast Leukotriene inhibitor LTR1 and LTD4 antagonist Asthma treatment
192 Morphine Opioid Analgesic µ receptor agonist
193 Muromonab-CD3 Immunosuppressive Mouse monoclonal anti-CD3 antibody Organ transplant (anti-rejection)
194 Mycophenolate Immunosuppressive Inhibits inosine monophosphate dehydrogenase activity
195 Nalbuphine Opioid antagonist µ receptor antagonist
196 Nalmefene Opioid antagonist
21 197 Nalorphine Opioid antagonist
198 Naloxone Opioid antagonist
199 Naltrexone Opioid antagonist
200 Naproxen NSAID Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitor
201 Nafcillin Penicillin antibiotic Cell wall synthesis inhibitor Penicillinase resistant penicillin Inhibits peptidoglycan cross-linking
202 Neomycin Aminoglycoside antibiotic Bactericidal protein synthesis inhibitor 30S ribosome Freezes initiation Topical
203 Neostigmine Anticholinesterase Vasodilator Treatment for myaesthenia gravis Promotes defecation and urination Bronchoconstrictor
204 Netilmicin Aminoglycoside antibiotic Bactericidal protein synthesis inhibitor 30S ribosome Freezes initiation
205 Nicotine Cholinomimetic Drug of abuse Nicotinic receptor agonist (skeletal muscle contraction)
22 Stimulant Smoking cessation medication
206 Nitrous oxide General anaesthetic Inhaled anaesthetic
207 Non-steroidal Anti-inflammatory Drugs (NSAIDs) Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitors
208 Norfloxacin Fluoroquinolone antibiotic DNA replication inhibitor Inhibits bacterial DNA gyrase
209 Nortriptyline Tricyclic antidepressant (TCA)
210 Omalizumab Anti-asthma Anti-IgE antibody
211 Oxacillin Penicillin antibiotic Cell wall synthesis inhibitor Pencillinase resistant penicillin Inhibits peptidoglycan cross-linking
212 Oxazepam Sedative/hypnotic Anxiolytic Benzodiazepine
Acts on GABAA receptor complex 213 Oxybutinin Anticholinergic Muscarinic receptor antagonist Prevents urination
214 Oxycodone Analgesic Opioid agonist
215 Oxytetracycline
23 Tetracycline antibiotic Bacteriostatic protein synthesis inhibitor 30S ribosome Prevents aminoacyl tRNA attachment
216 Paclitaxel Antineoplastic Natural product Plant alkaloid (taxane)
217 Palivizumab Antiviral Monoclonal antibody against the surface of respiratory syncytial virus
218 Para-aminosalicylic acid Antibiotic Nucleic acid and protein synthesis inhibitor Inhibits dihydropteroate synthetase Secondary TB drug
219 Paraldehyde Sedative/Hypnotic
220 Penicillins β lactam antibiotics Cell wall synthesis inhibitors Inhibit cross-linking of peptidoglycan
221 Penicillin G Penicillin antibiotic Cell wall synthesis inhibitor Acid labile Inhibits peptidoglycan cross-linking
222 Penicillin V Penicillin antibiotic Cell wall synthesis inhibitor More acid resistant than Penicillin G Inhibits peptidoglycan cross-linking
223 Pentazocine Opioid analgesic µ receptor partial agonist or antagonist
24 224 Pentobarbital Sedative/Hypnotic Barbiturate
225 Pentostatin Antineoplastic Miscellaneous Enzyme inhibitor (blocks purine synthesis)
226 Phencyclidine (PCP) Drug of abuse Hallucinogen
227 Phenobarbital Sedative/Hypnotic Anticonvulsant Barbiturate
228 Phenytoin Anticonvulsant Class I antiarrhythmic Na+ channel blocker (inactivated channels)
229 Phytonadione Vitamin K Warfarin antagonist
230 Piperacillin Penicillin antibiotic Cell wall synthesis inhibitor Anti-pseudomonal penicillin Inhibits peptidoglycan cross-linking
231 Piroxicam NSAID Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitor
232 Platelet Activating Factor (PAF) Inflammatory mediator Lipid Hypotensive
233 Polymyxin B
25 Antibiotic Disrupts gram negative cell membrane Binds phosphatidylethanolamine Bactericidal
234 Pramipexole Antiparkinson Dopamine agonist (non-ergot)
235 Prednisone Adrenocorticosteroid Glucocorticoid Antineoplastic Anti-inflammatory Not by inhalation
236 Primidone Anticonvulsant
237 Probenecid Uricosuric Adjunct in penicillin therapy
238 Procaine Local anaesthetic
239 Procaine Penicillin G Penicillin antibiotic Cell wall synthesis inhibitor Repository preparation Inhibits peptidoglycan cross-linking
240 Procarbazine Antineoplastic Miscellaneous Probably acts as alkylating agent
241 Promethazine Classical antihistamine Antipsychotic Antiemetic
H1 antagonist 242 Propofol General anaesthetic Intravenous anaesthetic
26 243 Prostaglandin D2 (PGD2) Bronchoconstrictor Cyclooxygenase product of arachidonate metabolism
244 Prostaglandin E2 (PGE2) Dinoprostone (Dinoprost) Oxytocic prostaglandin Inflammatory mediator Cyclooxygenase product of arachidonate metabolism Uterine stimulant Cervical ripener
245 Prostaglandin F2 (PGF2) Inflammatory mediator Cyclooxygenase product of arachidonate metabolism
246 Prostaglandin I2 (PGI2) Inflammatory mediator Inhibits platelet aggregation Cyclooxygenase product of arachidonate metabolism
247 Protamine Sulfate Heparin antagonist
248 Quinopristin/Dalfopristin Streptogramin antibiotic Protein synthesis inhibitor 50S ribosomal subunit
249 Resperidone Antipsychotic
250 Rifampin Antibiotic Nucleic acid synthesis inhibitor Inhibits DNA dependent RNA polymerase Major drug for TB
251 Rituxumab Antineoplastic Anti-CD20 antibody
252 Rofecoxib NSAID Anti-inflammatory
27 Cyclooxygenase 2 (COX-2) inhibitor
253 Ropinirole Antiparkinson Dopamine agonist (non-ergot)
254 Sargramostim (GM-CSF) Colony stimulating factor WBC (granulocyte and macrophage) stimulant
255 Sertraline Antidepressant Selective serotonin reuptake inhibitor (SSRI)
256 Sildenafil Vasodilator Promotes erection
257 Silver sulfadiazine Sulfonamide antibiotic Microbial nucleic acid and protein synthesis inhibitor Inhibits dihydropteroate synthetase Topical
258 Sirolimus Immunosuppressive Binds FKBP, inhibits mTOR (mammalian kinase target of rapamycin) & cell cycle progression
259 Spectinomycin Antibiotic Bacteriostatic protein synthesis inhibitor 30S ribosome
260 St. John’s Wort Dietary supplement Antidepressant
261 Streptokinase Thrombolytic
262 Streptomycin Aminoglycoside antibiotic
28 Bactericidal protein synthesis inhibitor 30S ribosome Freezes initiation
263 Sufentanil Opioid General anaesthetic Intravenous anaesthetic
264 Sulfacetamide Sulfonamide antibiotic Microbial nucleic acid and protein synthesis inhibitor Inhibits dihydropteroate synthetase Topical
265 Sulfadoxine Sulfonamide antibiotic Microbial nucleic acid and protein synthesis inhibitor Dihydropteroate synthetase inhibitor
266 Sulfamethoxazole Sulfonamide antibiotic Microbial nucleic acid and protein synthesis inhibitor Inhibits dihydropteroate synthetase
267 Sulfisoxazole Sulfonamide antibiotic Nucleic acid and protein synthesis inhibitor Inhibits dihydropteroate synthetase
268 Sulfonamides Antibiotics Nucleic acid and protein synthesis inhibitors Inhibit dihydropteroate synthetase
269 Sulindac NSAID Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitor
270 Tacrolimus Immunosuppressive
29 Antineoplastic Binds FKBP (FK506 binding protein) Inhibits calcineurin
271 Temazepam Sedative/Hypnotic Benzodiazepine
Acts on GABAA receptor complex 272 Tetracaine Local anaesthetic
273 Tetracycline Antibiotic Bacteriostatic protein synthesis inhibitor Antiulcer 30S ribosome Prevents aminoacyl tRNA attachment
274 Thalidomide Antineoplastic Leprosy treatment Anti-angiogenic Anti-TNFα
275 6-Thioguanine Antineoplastic Antimetabolite (“pseudofeedback inhibition” of HGPRT and PRP – purine synthesis)
276 Thiopental General anaesthetic Ultra-short-acting barbiturate
277 Thioridazine Antipsychotic Phenothiazine
278 Thiotepa Antineoplastic Alkylating agent
279 Thiothixene Antipsychotic
280 Thromboxane A2 (TXA2)
30 Autacoid Promotes platelet aggregation Cyclooxygenase product of arachidonate metabolism
281 Ticlopidine Antiplatelet ADP receptor antagonist
282 Ticarcillin Penicillin antibiotic Cell wall synthesis inhibitor Anti-pseudomonal penicillin Inhibits peptidoglycan cross-linking
283 Tissue plasminogen activators Thrombolytics
284 Tobramycin Aminoglycoside antibiotic Bactericidal protein synthesis inhibitor 30S ribosome Freezes initiation
285 Tolterodine Anticholinergic Muscarinic receptor antagonist Prevents urination
286 Tositumomab Antineoplastic Anti-CD20 antibody
287 Tranylcypromine Antidepressant Monoamine oxidase inhibitor (MAO-I)
288 Trastuzumab Antineoplastic Anti-HER2 antibody
289 Triazolam Sedative/Hypnotic Benzodiazepine
Acts on GABAA receptor complex 290 Trifluoperazine Antipsychotic
31 Phenothiazine
291 Trihexyphenidyl Antiparkinson Antimuscarinic
292 Trimethoprim Antibiotic Protein and nucleic acid synthesis inhibitor Folic acid antagonist Inhibits bacterial dihydrofolate reductase
293 Tripelennamine Classical antihistamine
H1 antagonist 294 Tumor necrosis factor α Cytokine Antineoplastic
295 Urokinase Thrombolytic
296 Valproic acid Anticonvulsant
297 Vancomycin Antibiotic Inhibits cell wall synthesis Not a β lactam
298 Vigabatrin Anticonvulsant Irreversible GABA aminotransferase inhibitor
299 Vinblastine Antineoplastic Vinca alkaloid Natural product
300 Vincristine Antineoplastic Vinca alkaloid Natural product
301 Warfarin
32 Anticoagulant Vitamin K synthesis inhibitor
302 Zafirlukast Leukotriene inhibitor
LTR1 and LTD4 antagonist Asthma treatment
303 Zileuton Leukotriene inhibitor 5-lipoxygenase inhibitor Used in asthma
304 Zolpidem Sedative/Hypnotic Non-benzodiazepine
33