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Clinical Practice Guideline for Limb Salvage Or Early Amputation
Limb Salvage or Early Amputation Evidence-Based Clinical Practice Guideline Adopted by: The American Academy of Orthopaedic Surgeons Board of Directors December 6, 2019 Endorsed by: Please cite this guideline as: American Academy of Orthopaedic Surgeons. Limb Salvage or Early Amputation Evidence-Based Clinical Practice Guideline. https://www.aaos.org/globalassets/quality-and-practice-resources/dod/ lsa-cpg-final-draft-12-10-19.pdf Published December 6, 2019 View background material via the LSA CPG eAppendix Disclaimer This clinical practice guideline was developed by a physician volunteer clinical practice guideline development group based on a formal systematic review of the available scientific and clinical information and accepted approaches to treatment and/or diagnosis. This clinical practice guideline is not intended to be a fixed protocol, as some patients may require more or less treatment or different means of diagnosis. Clinical patients may not necessarily be the same as those found in a clinical trial. Patient care and treatment should always be based on a clinician’s independent medical judgment, given the individual patient’s specific clinical circumstances. Disclosure Requirement In accordance with AAOS policy, all individuals whose names appear as authors or contributors to this clinical practice guideline filed a disclosure statement as part of the submission process. All panel members provided full disclosure of potential conflicts of interest prior to voting on the recommendations contained within this clinical practice guideline. Funding Source This clinical practice guideline was funded exclusively through a research grant provided by the United States Department of Defense with no funding from outside commercial sources to support the development of this document. -
Schwann Cell Supplementation in Neurosurgical Procedures After Neurotrauma Santiago R
ll Scienc Ce e f & o T l h a e Unda, J Cell Sci Ther 2018, 9:2 n r a r a p p u u DOI: 10.4172/2157-7013.1000281 y y o o J J Journal of Cell Science & Therapy ISSN: 2157-7013 Review Open Access Schwann Cell Supplementation in Neurosurgical Procedures after Neurotrauma Santiago R. Unda* Instituto de Biotecnología, Centro de Investigación e Innovación Tecnológica, Universidad Nacional de La Rioja, Argentina *Corresponding author: Santiago R. Unda, Instituto de Biotecnología, Centro de Investigación e Innovación Tecnológica, Universidad Nacional de La Rioja, Argentina, Tel: 3804277348; E-mail: [email protected] Rec Date: January 12, 2018, Acc Date: March 13, 2018, Pub Date: March 16, 2018 Copyright: © 2018 Santiago R. Unda. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract Nerve trauma is a common cause of quality of life decline, especially in young people. Causing a high impact in personal, psychological and economic issues. The Peripheral Nerve Injury (PNI) with a several grade of axonotmesis and neurotmesis represents a real challenge for neurosurgeons. However, the basic science has greatly contribute to axonal degeneration and regeneration knowledge, making possible to implement in new protocols with molecular and cellular techniques for improve nerve re-growth and to restore motor and sensitive function. The Schwann cell transplantation from different stem cells origins is one of the potential tools for new therapies. In this briefly review is included the recent results of animal and human neurosurgery protocols of Schwann cells transplantation for nerve recovery after a PNI. -
Management of Specific Wounds
7 Management of Specific Wounds Bite Wounds 174 Hygroma 234 Burns 183 Snakebite 239 Inhalation Injuries 195 Brown Recluse Spider Bites 240 Chemical Burns 196 Porcupine Quills 240 Electrical Injuries 197 Lower Extremity Shearing Wounds 243 Radiation Injuries 201 Plate 10: Pipe Insulation Protective Frostbite 204 Device: Elbow 248 Projectile Injuries 205 Plate 11: Pipe Insulation to Protect Explosive Munitions: Ballistic, the Greater Trochanter 250 Blast, and Thermal Injuries 227 Plate 12: Vacuum Drain Impalement Injuries 227 Management of Elbow Pressure Ulcers 228 Hygromas 252 Atlas of Small Animal Wound Management and Reconstructive Surgery, Fourth Edition. Michael M. Pavletic. © 2018 John Wiley & Sons, Inc. Published 2018 by John Wiley & Sons, Inc. Companion website: www.wiley.com/go/pavletic/atlas 173 174 Atlas of Small Animal Wound Management and Reconstructive Surgery BITE WOUNDS to the skin. Wounds may be covered by a thick hair coat and go unrecognized. The skin and underlying Introduction issues can be lacerated, stretched, crushed, and avulsed. Circulatory compromise from the division of vessels and compromise to collateral vascular channels can result in Bite wounds are among the most serious injuries seen in massive tissue necrosis. It may take several days before small animal practice, and can account for 10–15% of all the severity of tissue loss becomes evident. All bites veterinary trauma cases. The canine teeth are designed are considered contaminated wounds: the presence of for tissue penetration, the incisors for grasping, and the bacteria in the face of vascular compromise can precipi- molars/premolars for shearing tissue. The curved canine tate massive infection. teeth of large dogs are capable of deep penetration, whereas the smaller, straighter canine teeth of domestic cats can penetrate directly into tissues, leaving a rela- tively small cutaneous hole. -
Managing the Trauma Patient Presenting with the Lethal Trial
PRACTICE DEVELOPMENT IN ORTHOPAEDICS AND TRAUMA Managing the trauma patient presenting with the lethal trial Nicola Credland University of Hull Practice development in orthopaedics and trauma It is essential that orthopaedic and trauma practitioners develop and maintain their own skills and knowledge in order to help improve and deliver quality care for patients. The utilisation of research in practice development is an important part of the process for nurses endeavouring to deliver evidence based practice to improve care and service user experience. This new series entitled 'Practice development in orthopaedics and trauma' aims to showcase initiatives and innovations in practice development that have transformed delivery of quality care around the world and to provide readers with brief summaries of current thinking in relation to clinical issues that are common features of orthopaedic and trauma nursing practice. The feature will provide readers with a summary of an evidence base with the aim of empowering them to initiate discussion with colleagues and question their own practice. There will be associated CPD activities incorporating self-directed learning that will enhance the series and provide nurses with an opportunity to extend their learning. The International Journal of Orthopaedic and Trauma Nursing invites contributions from clinical staff, educators and students normally of between 1000 and 2500 words. Items may focus on, but are not restricted to, best practice and practice development initiatives relating to clinical care issues, implementation of research findings and education and development of the workforce in the clinical environment. INTRODUCTION Musculoskeletal injury brings with it a pattern of physical trauma that can result in death in the hours, days and months that follow. -
Types and Classification of Nerve Injury: a Review
Indian Journal of Clinical Practice, Vol. 31, No. 5, October 2020 REVIEW ARTICLE Types and Classification of Nerve Injury: A Review R JAYASRI KRUPAA*, KMK MASTHAN†, ARAVINTHA BABU N‡, SONA B# ABSTRACT Nerve injuries are the most common conditions with varying symptoms, depending on the severity, intensity and nerves involved. Though much information is available on the mechanisms of injury and regeneration, reliable treatments that ensure full functional recovery are limited. The type of nerve injury alters the treatment and prognosis. This review article aims to summarize the various types of nerve injuries and their classification. Keywords: Axonotmesis, neurotmesis, neurapraxia, Wallerian degeneration erve injuries are the most common conditions bundles of fibers called fascicles, which are covered with varying symptoms depending on the by perineurium. severity, intensity and nerves involved. N Â Epineurium: Finally, groups of fascicles are bundled Recovery after any nerve injury is variable. Though together to form the peripheral nerve (such as the much information exists on the mechanisms of injury median nerve), which is covered by epineurium. and regeneration, reliable treatments that ensure full functional recovery are limited. The type of nerve CLASSIFICATION injury alters the treatment and prognosis. This review article aims to summarize the various types of nerve Classification by Type of Nerve Injury injuries and classification of nerve injuries, which is There are three types of nerve injuries: useful in understanding their pathological basis, and to evaluate the prognosis for recovery. Nerve section Understanding the basic nerve anatomy is important Nerve section can be partial or complete, sharp or for the classification and also essential to evaluate blunt. -
Reconstructive
RECONSTRUCTIVE Muscle versus Nonmuscle Flaps in the Reconstruction of Chronic Osteomyelitis Defects Christopher J. Salgado, Background: Surgical treatment of chronic osteomyelitis requires aggressive M.D. debridement followed by wound coverage and obliteration of dead space with Samir Mardini, M.D. vascularized tissue. Controversy remains as to the effectiveness of different tissue Amir A. Jamali, M.D. types in achieving these goals and in the eradication of disease. Juan Ortiz, M.D. Methods: Chronic osteomyelitis was induced in 26 goat tibias using Staphylo- Raoul Gonzales, D.V.M., coccus aureus as an infecting inoculum. In a single stage, debridement followed Ph.D. by reconstruction using either a muscle flap (n ϭ 13) or a fasciocutaneous flap Hung-Chi Chen, M.D. (n ϭ 13) was performed. Flap donor sites were closed primarily and antibiotics El Paso, Texas; Kaohsiung, Taiwan; were given for 5 days postoperatively. Daily clinical evaluation for 1 year was and Sacramento, Calif. performed and monthly radiographs were obtained for 9 months and 1 year after the reconstruction. Results: Twenty-five flaps survived completely, and one nonmuscle flap under- went partial flap loss following a period of venous congestion. There were no postoperative complications in the muscle flap group. Two goats (15 percent) in the nonmuscle group developed superficial wounds in the immediate post- operative period that resolved with conservative management. No limbs had recurrent osteomyelitis wounds at 1 year of clinical follow-up examination. Radiographic evidence of osteomyelitis was present in two goats (15 percent) in the muscle group and one goat (8 percent) in the nonmuscle group. -
Energetické Drinky
servis•test S odborníkem na výživu Pavlem Suchánkem jsme 6 tipů ochutnali nejznámější energetické nápoje. Denně si z obchodů dejte maximálně jeden a nejlépe jen malou plechovku. Produkt Co v něm je Názor odborníka Jak nám chutná ▲ 32 mg kofeinu/100 ml Obsahuje extrakt z guara- Chutí trochu připomíná BIG SHOCK 400 mg taurinu/100 ml ny a ženšenu, ale zřejmě multivitaminový džus. Líbilo se Jsou zdravé? EXOTIC JUICY, 195 kJ/100 ml jen v malém množství. nám, že není tolik sladký. al-NamuRA sacharidy 11,1 g Pozitivní je nižší obsah 35 Kč/500 ml vitamin B5 1,2 mg vitaminu B3. Kofein 9/10 vitamin B3 3,6 mg odpovídá dvěma šálkům vitamin B6 0,4 mg kávy. Půllitr pokryje Energetické dávku cukru na celý den. ▲ RED BULL 32 mg kofeinu/100 ml Kofein v kombinaci se Chuťově je nejvyrovnanější, ENERGY DRINK 400 mg taurinu/100 ml sacharózou, klasickým lehce nakyslá chuť příjemně RED BULL 192 kJ/100 ml cukrem a glukózou tu osvěžuje. drinky 40 Kč/250 ml sacharidy 11 g funguje jako rychlé 8/10 vitamin B3 8 mg palivo pro mozek. Pozor Nakopnou, když je nejhůř, ale nevyplatí se vitamin B5 2 mg na obsah cukru, malá vitamin B6 2 mg plechovka obsahuje to s nimi přehánět. Jedna půllitrová plechovka vitamin B12 2 mg polovinu doporučené energetického nápoje do těla dostane tolik kofeinu, denní dávky. jako byste naráz vypili dva až tři šálky silné kávy. To 30 mg kofeinu/100 ml Obsahuje ženšen Obsahuje nejvíc cukru ze ▲ už s nervovou soustavou může pořádně zamávat. MONSTER 400 mg taurinu/ 100 ml a L -karnitin, ale málo všech a na chuti je to znát. -
Ketamine for Paediatric Sedation/Analgesia in the Emergency Department
275 Emerg Med J: first published as 10.1136/emj.2003.005769 on 22 April 2004. Downloaded from CLINICAL TOPIC REVIEW Emerg Med J: first published as 10.1136/emj.2003.005769 on 22 April 2004. Downloaded from Ketamine for paediatric sedation/analgesia in the emergency department M C Howes ............................................................................................................................... Emerg Med J 2004;21:275–280. doi: 10.1136/emj.2003.005769 This review investigates the use of ketamine for paediatric pain or other noxious stimuli, with relative preservation of respiratory and cardiovascular sedation and analgesia in the emergency department functions despite profound amnesia and analge- ........................................................................... sia,10 30–32 described as ‘‘cataleptic.’’10 This trance- like state of sensory isolation provides a unique combination of amnesia, sedation, and analge- he injured child presents a challenge to sia.7103031 The eyes often remain open, though emergency department (ED) practitioners. nystagmus is commonly seen. Heart rate and The pain and distress can be upsetting for T blood pressure remain stable, and are often staff as well as parents. The child’s distress can stimulated, possibly through sympathomimetic be compounded by the fear of a painful actions.30 31 33 Functional residual capacity and procedure to follow, previous conditioning from tidal volume are preserved, with bronchial unexpected ‘‘jabs’’ when receiving immunisa- smooth muscle relaxation34–37 and maintenance tions, or previous visits to an ED.1 of airway patency and respiration.10 30 31 38 As doctors we strive to relieve pain and However, despite the enthusiasm of many suffering, and swear to do no harm. Forced authors and practitioners, ketamine may not be restraint, still performed in some departments in the ideal agent. -
A Comparative Study of Anaesthetic Agents on High Voltage Activated Calcium
bioRxiv preprint doi: https://doi.org/10.1101/2020.12.17.423182; this version posted December 18, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. A COMPARATIVE STUDY OF ANAESTHETIC AGENTS ON HIGH VOLTAGE ACTIVATED CALCIUM CHANNEL CURRENTS IN IDENTIFIED MOLLUSCAN NEURONS Terrence J. Morris1, Philip M. Hopkins2,3 and William Winlow4,5 1Department Science and Technology - Biology, Douglas College, 700 Ryal Avenue, New Westminster, British Columbia, Canada; 2 Leeds Institute of Medical Research at St James’s, School of Medicine, University of Leeds, Leeds, United Kingdom; 3Malignant Hyperthermia Investigation Unit, Leeds Institute of Molecular Medicine, St. James’s University Hospital, Leeds, LS9 7TF, United Kingdom; 4 Department of Biology, University of Naples Federico II, Via Cintia 26, 80126, Naples, Italy; 5Institute of Ageing and Chronic Diseases, University of Liverpool, Liverpool, United Kingdom. Corresponding author: William Winlow Key Words: General anaesthetic, calcium channels, Lymnaea, light yellow cells SUMMARY 1. Using the two electrode voltage clamp configuration, a high voltage activated whole-cell Ca2+ channel current (IBa) was recorded from a cluster of neurosecretory ‘Light Yellow’ Cells (LYC) in the right parietal ganglion of the pond snail Lymnaea stagnalis. 2. Recordings of IBa from LYCs show a reversible concentration-dependent depression of current amplitude in the presence of the volatile anaesthetics halothane, isoflurane and sevoflurane, or the non-volatile anaesthetic pentobarbitone at clinical concentrations. 3. In the presence of the anaesthetics investigated, IBa measured at the end of the depolarizing test pulse showed proportionally greater depression than that at measured peak amplitude, as well as significant decrease in the rate of activation or increase in inactivation or both. -
Prognostic Factors for Outcome and Survival After Laparotomy in Patients with Pancreatic Trauma: One Single-Center Experience
Prognostic Factors for Outcome and Survival after Laparotomy in Patients with Pancreatic Trauma: One Single-center Experience. Chao Yang Jinling hospital Baochen Liu Jinling hospital Cuili Wu Jinling hospital Yongle Wang jinling hospital Kai Wang jinling hospital Weiqin Li Jinling hospital weiwei ding ( [email protected] ) Jinling hospital https://orcid.org/0000-0002-5026-689X Research Keywords: pancreatic trauma, prognosis, risk factor, logistic regression analysis Posted Date: April 9th, 2020 DOI: https://doi.org/10.21203/rs.3.rs-21555/v1 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Page 1/13 Abstract Background: Pancreatic trauma results in signicant morbidity and mortality. Few studies have investigated the postoperative prognostic factors in patients with pancreatic trauma after surgery. Methods: A retrospective study was conducted on 152 consecutive patients with pancreatic trauma who underwent surgery in Jinling Hospital, a national referral trauma center in China, from January 2012 to December 2019. Univariate and binary logistic regression analyses were performed to identify the perioperative clinical parameters that may affect the morbidity of the patients. Results: A total of 184 patients with pancreatic trauma were admitted during the study period, and 32 patients with nonoperative management were excluded. The remaining 152 patients underwent laparotomy due to pancreatic trauma. Sixty-four patients were referred from other centers due to postoperative complications. Abdominal bleeding caused by pancreatic leakage ( 10 of all deaths) and severe intra-abdominal infection (12 of all deaths) were the major causes of mortality. Twenty-eight (77.8%) of the 36 patients who had damage control laparotomy survived. -
Dionaea Muscipula)
bioRxiv preprint doi: https://doi.org/10.1101/645150; this version posted May 22, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. 1 RESEARCH PAPER 2 Anaesthesia with diethyl ether impairs jasmonate signalling in the 3 carnivorous plant Venus flytrap (Dionaea muscipula). 4 Andrej Pavlovič1*, Michaela Libiaková2, Boris Bokor2,3, Jana Jakšová1, Ivan Petřík4, Ondřej 5 Novák4, František Baluška5 6 1 Department of Biophysics, Centre of the Region Haná for Biotechnological and Agricultural 7 Research, Faculty of Science, Palacký University, Šlechtitelů 27, CZ-783 71, Olomouc, Czech 8 Republic 9 2 Department of Plant Physiology, Faculty of Natural Sciences, Comenius University in 10 Bratislava, Ilkovičova 6, Mlynská dolina B2, SK-842 15, Bratislava, Slovakia 11 3 Comenius University Science Park, Comenius University in Bratislava, Ilkovičova 8, SK-841 12 04, Bratislava, Slovakia 13 4 Laboratory of Growth Regulators, Centre of the Region Haná for Biotechnological and 14 Agricultural Research, Institute of Experimental Botany CAS and Faculty of Science, Palacký 15 University, Šlechtitelů 27, CZ-783 71, Olomouc, Czech Republic 16 5IZMB, University of Bonn, Kirschallee 1, 53115 Bonn, Germany 17 *- author for correspondence: [email protected], +420 585 634 831 18 Running title: Anaesthetic impairs jasmonate signalling in carnivorous plant 19 Highlight: Carnivorous plant Venus flytrap (Dionaea muscipula) is unresponsive to insect 20 prey or herbivore attack due to impaired electrical and jasmonate signalling under general 21 anaesthesia induced by diethyl ether. -
En Bloc Resection of Extra-Peritoneal Soft Tissue Neoplasms Incorporating a Type III Internal Hemipelvectomy: a Novel Approach Sanjay S Reddy1* and Norman D Bloom2
Reddy and Bloom World Journal of Surgical Oncology 2012, 10:222 http://www.wjso.com/content/10/1/222 WORLD JOURNAL OF SURGICAL ONCOLOGY REVIEW Open Access En bloc resection of extra-peritoneal soft tissue neoplasms incorporating a type III internal hemipelvectomy: a novel approach Sanjay S Reddy1* and Norman D Bloom2 Abstract Background: A type III hemipelvectomy has been utilized for the resection of tumors arising from the superior or inferior pubic rami. Methods: In eight patients, we incorporated a type III internal hemipelvectomy to achieve an en bloc R0 resection for tumors extending through the obturator foramen or into the ischiorectal fossa. The pelvic ring was reconstructed utilizing marlex mesh. This allowed for pelvic stability and abdominal wall reconstruction with obliteration of the obturator space to prevent herniations. Results: All eight patients had an R0 resection with an overall survival of 88% and with average follow up of 9.5 years. Functional evaluation utilizing the Enneking classification system, which evaluates motion, pain, stability and strength of the affected extremity, revealed a 62% excellent result and a 37% good result. No significant complications were associated with the operative procedure. Marlex mesh reconstruction provided pelvic stability and eliminated all hernial defects. Conclusion: The superior and inferior pubic rami provide a barrier to a resection for tumors that arise in the extra-peritoneal pelvis extending through the obturator foramen or ischiorectal fossa. Incorporating a type III internal