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Original article

Pleiotropic associations of heterozygosity for the SERPINA1 Z allele in the UK Biobank

Katherine A. Fawcett, Kijoung Song, Guoqing Qian, Aliki-Eleni Farmaki, Richard Packer, Catherine John, Nick Shrine, Raquel Granell, Sue Ring, Nicholas J. Timpson, Laura M. Yerges-Armstrong, Richard Eastell, Louise V. Wain, Robert A. Scott, Martin D. Tobin, Ian P. Hall

Please cite this article as: Fawcett KA, Song K, Qian G, et al. Pleiotropic associations of heterozygosity for the SERPINA1 Z allele in the UK Biobank. ERJ Open Res 2021; in press (https://doi.org/10.1183/23120541.00049-2021).

This manuscript has recently been accepted for publication in the ERJ Open Research. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online.

Copyright ©The authors 2021. This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact [email protected] Pleiotropic associations of heterozygosity for the SERPINA1 Z allele in the UK Biobank

Katherine A Fawcett1, Kijoung Song2, Guoqing Qian3,4, Aliki-Eleni Farmaki5, Richard Packer1, Catherine

John1, Nick Shrine1, Raquel Granell6, Sue Ring6, Nicholas J Timpson6,7, Laura M Yerges-Armstrong2,

Richard Eastell8, Louise V Wain1,9, Robert A Scott10, Martin D Tobin1,9*¶, Ian P Hall4*¶

1. Department of Health Sciences, University of Leicester, Leicester, LE1 7RH, UK

2. Human Genetics, GlaxoSmithKline, Collegeville, PA, US

3. Department of General Internal Medicine, Ningbo First Hospital, Ningbo City, Zhejiang

Province, China, 315010

4. Division of Respiratory Medicine, University of Nottingham, & NIHR Nottingham BRC, NUH

NHS Trust, Nottingham NG7 2UH, UK

5. MRC Unit for Lifelong Health and Ageing, Institute of Cardiovascular Science, University

College London, 1-19 Torrington Place, London WC1E 7HB, UK

6. Medical Research Council (MRC) Integrative Epidemiology Unit, Population Health Sciences,

Bristol Medical School, University of Bristol, Bristol, UK

7. Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK

8. Department of Oncology and Metabolism, University of Sheffield, S10 2RX, UK

9. National Institute for Health Research, Leicester Respiratory Biomedical Research Centre,

Glenfield Hospital, Leicester, LE3 9QP, UK

10. Human Genetics - R&D, GSK Medicines Research Centre, Gunnels Wood Road, Stevenage,

Hertfordshire, SG1 2NY, UK

*Corresponding authors

E-mails: [email protected], [email protected]

¶ These authors contributed equally to this work

Take home message

Heterozygosity for the SERPINA1 Z allele is associated with higher lung function in non-smokers, but this advantage is abolished by smoking, as well as a variety of non-respiratory diseases and traits, including liver-, heart-, and bone-related conditions.

Abstract

Homozygosity for the SERPINA1 Z allele causes alpha-1 antitrypsin deficiency, a rare condition that can cause lung and liver disease. However, the effects of Z allele heterozygosity on non-respiratory phenotypes, and on lung function in the general population, remain unclear.

We conducted a large population-based study to determine Z allele effects on >2,400 phenotypes in

UK Biobank (N>303,353).

Z allele heterozygosity was strongly associated with increased height (β=1.02cm, P=3.91x10-68), and with other non-respiratory phenotypes including increased risk of gall bladder disease, reduced risk of heart disease and lower blood pressure, reduced risk of osteoarthritis and reduced bone mineral density, increased risk of headache and enlarged prostate, as well as with blood biomarkers of liver function. Heterozygosity was associated with higher height-adjusted forced expiratory volume in 1

-4 second (FEV1) (β=19.36ml, P=9.21x10 ) and FEV1/forced vital capacity (FEV1/FVC) (β=0.0031,

P=1.22x10-5) in non-smokers, whereas in smokers this protective effect was abolished. Furthermore, we show for the first time that sex modifies the association of the Z allele on lung function.

We conclude that Z allele heterozygosity and homozygosity exhibit opposing effects on lung function in the UK population, and that these associations are modified by smoking and sex. In exploratory analyses, heterozygosity for the Z allele also showed pleiotropic associations with non-respiratory health-related traits and disease risk.

Introduction

Homozygosity for the SERPINA1 Z allele (rs28929474(T)) is the commonest cause of severe alpha-1 antitrypsin deficiency (AATD) and is a well-established genetic risk factor for lung diseases such as chronic obstructive pulmonary disease (COPD). However, the health consequences of heterozygosity for the Z allele are not as well-understood[1]. Given that approximately one in 30

Europeans are heterozygous for the Z allele, the phenotypic consequences of carriage of this allele could have important public health implications.

Some previous studies have sought to characterise the effect of Z allele heterozygosity on non- respiratory traits, particular liver diseases [2-6]. However, these have often been carried out in small sample sizes and/or clinical subgroups. The recent development of phenome-wide association studies (PheWAS) and the availability of the well-phenotyped UK Biobank population-based cohort provides a platform for systematic investigation of the effects of heterozygosity for the Z allele on non-respiratory traits. PheWAS test the association between genetic variants and a large number of phenotypic traits, including diseases and their subtypes, and potential intermediate phenotypes[7].

This differs from genome-wide association studies (GWAS), which test a large number of variants across the genome for association with only one trait.

The effect of Z allele heterozygosity on lung function traits and lung disease has been the subject of many studies. Recent COPD case-control and family-based studies have shown reduced lung function and increased risk of COPD in heterozygous current and former smokers[8-11]. However, a population-based study demonstrated no significant reductions in lung function in heterozygous smokers, despite having greater numbers of heterozygous smokers compared to previous studies[12]. It also showed enhanced lung function in heterozygous individuals overall, partially explained by strong association of the Z allele with increased height. This discrepancy may be due, in part, to the fact that identifying and recruiting study participants based on their health status (as in case-control studies[8, 9]) or based on the health status of a family member[10, 11], can lead to

causal estimates that are subject to ascertainment bias[13], whereas population-based studies[12,

14] overcome these biases. The effects of the Z allele on lung function in relation to smoking status therefore remain uncertain.

Finally, despite evidence for sex-differential effects of Z allele homozygosity on lung function [15,

16], we are not aware of any studies that have compared the effect of Z allele heterozygosity on lung function in males versus females.

We therefore systematically evaluated the effects of Z allele heterozygosity in the UK biobank population, which in total includes >18,000 Z allele heterozygotes. We aimed to (i) undertake the most extensive phenome-wide association study to date, including blood biomarkers, for Z allele heterozygosity and homozygosity to identify effects beyond the respiratory system, and (ii) to fully define the effects of Z allele heterozygosity on lung function measures (FEV1 and FVC) in smokers and non-smokers and in males and females.

Methods

Cohorts

Ethics statement. This study used anonymised data from UK Biobank, which has ethical approval from the UK National Health Service (NHS) National Research Ethics Service (Ref 11/NW/0382). All participants provided written informed consent. Ethical approval for the ALSPAC study was obtained from the ALSPAC Ethics and Law Committee and the Local Research Ethics Committees.

Written informed consent for the use of data collected via questionnaires and clinics was obtained from participants, parents or guardians following the recommendations of the ALSPAC Ethics and

Law Committee at the time.

UK Biobank. The UK Biobank data resource is described elsewhere (see http://www.ukbiobank.ac.uk). Genotyping was undertaken using the Affymetrix Axiom® UK BiLEVE and UK Biobank arrays[17]. Genotypes were imputed based on the Human Reference Consortium

(HRC) panel, as described elsewhere[18]. Genotyping quality control was performed as described previously[19]. UK Biobank individuals were selected for inclusion in PheWAS analyses if they met the following criteria: (i) they had no missing data for sex or age; (ii) they had genome-wide imputed genetic data for rs28929474; (iii) they were of genetically determined European ancestry (see [19] for details) and; (iv) they were not first- or second-degree relatives. For lung function analyses, individuals were additionally required to have spirometry data that passed quality control, as described previously[19] and to have full data for height and smoking status as well as data derived from direct genotyping for rs28929474 (N = 303,353).

The Avon Longitudinal Study of Parents and Children (ALSPAC). The ALSPAC cohort was invited to participate in this study after the main analyses in UK Biobank had been completed in order to explore the effects of the Z allele on height and lung function in younger age groups. ALSPAC children were genotyped using the Illumina HumanHap550 quad genome-wide SNP genotyping platform (Illumina Inc., San Diego, CA, USA) by the Wellcome Trust Sanger Institute (WTSI;

Cambridge, UK) and the Laboratory Corporation of America (LCA, Burlington, NC, USA), using support from 23andMe. Further details of ALSPAC are available in the Supplemental materials.

Participants were excluded from this study if they had incorrectly recorded sex, minimal or excessive heterozygosity, disproportionate levels of individual missingness (>3%), evidence of cryptic relatedness or non-European ancestry.

Phenome-wide association studies (PheWAS)

To identify whether SERPINA1 Z allele heterozygosity or homozygosity was associated with respiratory and non-respiratory traits and diseases, two PheWAS across all available traits were performed. The first compared traits in individuals heterozygous for the Z allele vs wild-type, and the second compared individuals homozygous for the Z allele vs wild type and heterozygotes combined

(recessive genetic model). Up to 379,101 individuals were available for these analyses. Traits included UK Biobank baseline measures (from both questionnaires and physical measures), self- reported medication usage, and operative procedures, as well as those captured in Office of

Population Censuses and Surveys codes from the electronic health record. We also included self- reported disease variables and those from hospital episode statistics (ICD-10 codes truncated to three-character codes and combined in block and chapter groups) as well as combining both self- report and hospital diagnosed diseases where possible to maximise power. The analysis included

2,411 traits (traits with >200 cases were included[20]). Analyses were conducted in unrelated

European-ancestry individuals (KING kinship coefficient of <0.0442), and were adjusted for age, age2, sex, genotyping array, and ten ancestry principal components. Logistic models were fitted for binary outcomes, and linear models were fitted for quantitative outcomes (rank transformed to normality).

False discovery rates were calculated according to the number of the traits in the analysis.

Statistical analyses for biomarkers, lung function, COPD and height

For continuous traits, linear regression models adjusted for sex, age, age2, the first ten ancestry- based principal components (PCs) and genotyping array were tested in R. SERPINA1 Z genotype

(derived from direct genotyping) was coded according to the genetic model tested: either heterozygous (ie. heterozygous versus wild-type) or recessive. For lung function analyses, ever- smoking status and standing height were also included in the models unless indicated. To test for interaction of Z allele hetero- or homo-zygosity with ever-smoking status and sex, interaction terms for sex and smoking were added to the model. Association testing with moderate-severe COPD

(defined as FEV1/FVC < 0.7 and FEV1 < 80% predicted) or COPD GOLD 1-4 (defined as FEV1/FVC < 0.7) was carried out using logistic regression in R adjusting for covariates sex, age, age2, ever-smoking status, height, the first ten ancestry-based principal components (PCs) and genotyping array. In addition to the biomarkers available from UK Biobank, we calculated estimated glomerular filtration rate (eGFR) using the following formula: If cystatin C (cys) <= 0.8 then eGFR = 133*((cys/0.8)**-

0.499)*(0.996**age)*[0.932 if female] whereas if cystatin C (cys) > 0.8 then eGFR =

133*((cys/0.8)**-1.328)*(0.996**age)*[0.932 if female].

In ALSPAC, the association of Z allele heterozygosity with height and lung function z-scores were examined using linear regression models including age and gender (and including height in the lung function analyses).

Polygenic risk scores

Polygenic risk scores for lower FEV1/FVC were generated in UK Biobank using Plink v1.90b3. These were based on 60,730 autosomal variants with minor allele frequency>1%, P<0.05 (for the

2 association with FEV1/FVC in UK Biobank) and LD pruned to r <0.1 in 250kb windows. Variants were weighted by FEV1/FVC beta coefficients from the SpiroMeta consortium cohorts[19].

Results

Frequency of the SERPINA1 Z in UK Biobank

Amongst 411,002 unrelated, European UK Biobank participants with full sex, age, height, smoking status and genotyping data, 16,199 (3.94%) were heterozygous and 129 (0.0314%) were homozygous for the Z allele. There were fewer ZZ homozygotes than expected under Hardy-

Weinberg Equilibrium in all samples (P = 0.004), ever-smokers (P = 0.003), individuals over 60 years of age (P = 0.007) and in females (P = 0.007) (S1 Table), consistent with reduced survival.

Phenome-wide association studies of the Z allele

To explore the effect of Z allele heterozygosity and homozygosity on a broad range of phenotypes we performed two PheWAS. The phenotypes most strongly associated with Z allele heterozygosity and Z allele homozygosity (FDR < 0.01) are shown in Fig. 1A and 1B respectively (full results are in S2

Table and S3 Table). Standing height, alpha 1 antitrypsin deficiency, and various respiratory phenotypes (lung function, reported emphysema, chronic bronchitis and COPD) were strongly associated with the Z allele under either genetic model. However, we also detected strong associations between Z allele heterozygosity and a number of other phenotypes, including increased risk of gall stones (OR = 1.35, P = 1.69x10-16), gall bladder removal (OR = 1.51, P = 1.85x10-29) and bile duct disease (OR = 1.25, P = 5.42x10-8); cardiovascular phenotypes such as lower risk of heart disease

(OR = 0.84, P = 6.66x10-6) and family history of heart disease, and lower blood pressure (P = 1.02x10-

10); musculoskeletal phenotypes such as a higher grip strength (P = 5.67 x 10-7), lower risk of osteoarthritis, particularly of knee or hip (OR = 0.85, P = 1.18x10-6), lower bone mineral density (P =

1.40x10-5) and higher risk of osteoporosis (OR = 1.17, P = 0.001); and also higher risk of headache

(OR = 1.12, P = 5.66x10-9) and enlarged prostate (OR = 1.26, P = 1.95x10-7). The pheWAS also included blood counts for a variety of different cell types, showing reduced reticulocytes in individuals heterozygous for the Z allele. Z allele homozygosity was associated with increased

haemoglobin (P = 7.17x10-10), haematocrit (P = 6.17x10-8) and red blood cells (P = 5.91x10-5), as well as optic neuritis (OR = 26.9, P = 4.32x10-6) and pancreatitis (OR = 6.07, P = 7.76x10-5).

To extend these analyses to traits not previously available for the PheWAS, we investigated the effect of Z allele heterozygosity and homozygosity on thirty key blood biochemistry markers in UK

Biobank data (Table 1). Heterozygosity for the Z allele was associated with a variety of liver function markers including higher alanine aminotransferase (β = 1.16 U/l, P = 2.95x10-25), higher albumin (β =

0.71 g/l, P = 3.11x10-229), higher alkaline phosphatase (β = 2.97 U/l, P = 5.81x10-44), higher aspartate aminotransferase (0.71 U/l, P = 2.27x10-16) and higher direct bilirubin (β = 0.041 umol/l, P = 1.64x10-

8). There were also strong associations with calcium (β = 0.012 mmol/l, P = 4.01x10-50), cystatin C

(0.0090 mg/l, P = 8.91x10-12), C-reactive protein (β = -0.17 mg/l, P = 1.11x10-6) and IGF-1 (β = -0.21 nmol/l, P = 2.35x10-6). Heterozygotes exhibited higher sex hormone binding globulin (SHBG) (β =

4.53 nmol/l, P = 1.06x10-95) and testosterone (β = 0.37 nmol/l, P = 1.84x10-57). The association with higher testosterone was driven by heterozygosity in males (0.76 nmol/l [SE 0.045], P = 3.38x10-64), but not females (-0.030 nmol/l [SE 0.0079], P = 0.00015).

Table 1. Association between the SERPINA1 Z allele and blood biomarkers in unrelated, European

UK Biobank participants

Heterozygous genetic model Recessive genetic model Biomarker Beta (se) p Beta (se) p Alanine aminotransferase (U/l) 1.163 (0.112) 2.95x10-25 3.037 (1.246) 0.015 Albumin (g/l) 0.712 (0.022) 3.11x10-229 0.306 (0.243) 0.208 Alkaline phosphatase (U/l) 2.968 (0.213) 5.81x10-44 2.379 (2.373) 0.316 Apolipoprotein B (g/l) -0.0037 (0.0021) 0.082 0.042 (0.024) 0.086 Apolipoprotein A (g/l) -0.0045 (0.0019) 0.020 0.019 (0.022) 0.375 Aspartate aminotransferase (U/l) 0.707 (0.086) 2.27x10-16 6.353 (0.956) 3.04x10-11 C-reactive protein (mg/l) -0.174 (0.036) 1.11x10-6 0.192 (0.396) 0.628 Calcium (mmol/l) 0.012 (0.00080) 4.01x10-50 0.01 (0.009) 0.265 Cholesterol (mmol/l) 0.0051 (0.0092) 0.576 0.19 (0.102) 0.063 Creatinine (umol/l) -0.067 (0.129) 0.601 -0.94 (1.435) 0.512 Cystatin C (mg/l) 0.0090 (0.0013) 8.91x10-12 0.019 (0.015) 0.204 Direct bilirubin (umol/l) 0.041 (0.0073) 1.64x10-8 0.158 (0.079) 0.046 eGFR* -0.241 (0.157) 0.125 -1.810 (1.732) 0.296 Gamma glutamyltransferase (U/l) 0.253 (0.342) 0.460 8.045 (3.818) 0.035 Glucose (mmol/l) -0.0032 (0.010) 0.758 -0.133 (0.114) 0.244 Glycated haemoglobin (HbA1c) (mmol/mol) -0.187 (0.052) 3.40x10-4 -1.781 (0.588) 2.46x10-3 HDL cholesterol (mmol/l) 0.0015 (0.0030) 0.605 0.142 (0.033) 2.01x10-5 IGF-1 (nmol/l) -0.212 (0.045) 2.35x10-6 -2.245 (0.5) 7.19x10-6 LDL direct (mmol/l) 0.011 (0.007) 0.113 0.115 (0.079) 0.145 Lipoprotein A (nmol/l) -0.324 (0.452) 0.474 -0.151 (5.115) 0.976 Oestradiol (pmol/l) 9.577 (8.441) 0.257 88.051 (96.144) 0.360 Phosphate (mmol/l) 0.0027 (0.0013) 0.042 -0.014 (0.015) 0.352 Rheumatoid factor (IU/ml) 0.113 (0.529) 0.832 -3.27 (5.7) 0.566 SHBG (nmol/l) 4.531 (0.218) 1.06x10-95 40.573 (2.402) 5.33x10-64 Testosterone (nmol/l) 0.37 (0.023) 1.84x10-57 2.986 (0.258) 6.96x10-31 Total bilirubin (umol/l) 0.146 (0.035) 3.54x10-5 0.52 (0.391) 0.184 Total protein (g/l) 0.578 (0.035) 1.06x10-62 0.459 (0.382) 0.229 Triglycerides (mmol/l) -0.023 (0.0082) 4.69x10-3 -0.324 (0.092) 4.21x10-4 Urate (umol/l) 1.096 (0.56) 0.050 -1.325 (6.252) 0.832 Urea (mmol/l) 0.051 (0.011) 2.69x10-6 0.06 (0.122) 0.620 Vitamin D (nmol/l) -0.041 (0.175) 0.816 -2.547 (1.955) 0.193 Results are based on linear regression adjusting for sex, age, age2, ancestry-based principal components, and genotyping array. The heterozygous or recessive genetic model was also included in the regression as shown. * estimated glomerular filtration rate (eGFR) was calculated using the following formula: If cystatin C (cys) <= 0.8 then eGFR = 133*((cys/0.8)**-

0.499)*(0.996**age)*[0.932 if female] whereas if cystatin C (cys) > 0.8 then eGFR =

133*((cys/0.8)**-1.328)*(0.996**age)*[0.932 if female]. HDL = high-density lipoprotein, IGF-1 = insulin-like growth factor 1, LDL = low-density lipoprotein, and SHBG = sex hormone binding globulin

Z allele heterozygosity is associated with increased lung function in non-smokers

We tested association of heterozygosity for the SERPINA1 Z allele with lung function traits in unrelated, European UK Biobank participants with full sex, age, height, smoking status, lung function and genotyping data (Table 2). Individuals heterozygous for the Z allele exhibited higher FEV1 (β =

9.26 ml, P = 0.041) but no association with FEV1/FVC or FVC compared to wild-type (Table 2).

However, in stratified analyses of UK Biobank never- and ever-smokers, we found that

- heterozygosity for the Z allele was associated with a large increase in FEV1 (β = 19.36 ml, P = 9.21x10

4 -5 ) and increased FEV1/FVC (β = 0.0031, P = 1.22x10 ) in never-smokers, but not in ever-smokers

(Table 2). The FEV1 association in never-smokers was only slightly attenuated by including a quadratic height term in the regression (β = 18.85 ml, P = 1.23 x 10-3). Statistical tests of Z

- allele*ever-smoking interactions showed interactions for FEV1 (P = 0.022) and FEV1/FVC (P = 1.06x10

4) (S4 Table). Furthermore, heterozygous ever-smokers exhibited a small increased risk of COPD

(both moderate-severe COPD, OR = 1.16, P = 0.005, and COPD GOLD 1-4, OR = 1.12, P = 0.001), whereas heterozygous never-smokers did not (Table 2).

Table 2. Association between the SERPINA1 Z allele and height, lung function traits, and COPD in unrelated, European UK Biobank participants

a b N (test vs Height (cm) FEV1 (ml) FEV1/FVC FVC (ml) COPD COPD GOLD 1-4 Genetic Smoking comparison) OR P OR P Beta Beta Beta model status p p Beta (se) p p (95% (95% CI) (se) (se) (se) CI) 11877 vs 1.05 1.04 All 291383 1.023 9.26 0.00091 9.38 (0.96- 0.268 (0.98 - 0.171 (0.059) 3.91x10-68 (4.53) 0.041 (0.00057) 0.108 (5.43) 0.084 1.14) 1.09) 5357 vs 1.16 1.12 Ever- 1.027 -2.63 -0.0017 5.47 Het 133779 8.53x10-32 0.709 0.062 0.509 (1.05- 0.005 (1.04 - 0.001 smokers (0.087) (7.05) (0.00091) (8.28) 1.29) 1.20) 6520 vs 0.87 0.93 Never- 1.022 19.36 0.0031 12.77 157604 3.03x10-38 9.21x10-4 1.22x10-5 0.074 (0.75- 0.070 (0.86 - 0.113 smokers (0.079) (5.84) (0.00071) (7.15) 1.01) 1.02) 93 vs 303260 7.42 4.58 All 1.644 -249.21 -0.051 -132.16 (4.29 - 5.67x10-14 (2.93 - 8.67x10-12 (0.650) 0.011 (50.22) 6.96x10-7 (0.0063) 3.54x10-16 (60.09) 0.028 12.27) 7.05) 35 vs 139136 9.19 6.13 Ever- 1.242 -379.21 -0.081 -177.95 Rec 0.242 9.30x10-6 2.00x10-13 0.076 (4.19- 6.27x10-9 (3.07 - 2.30x10-7 smokers (1.062) (85.54) (0.011) (100.35) 19.00) 12.29) 58 vs 164124 5.98 3.68 Never- 1.873 -174.68 -0.034 -107.69 0.023 0.004 4.95x10-6 0.147 (2.66- 2.69x10-6 (2.01 - 1.11x10-5 smokers (0.821) (60.68) (0.0074) (74.23) 12.03) 6.47) Results are based on linear (or logistic, in the case of COPD) regression adjusting for sex, age, age2, ancestry-based principal components, genotyping array

and, in the case of lung function and COPD, standing height. The heterozygote or recessive genetic model was also included in the regression as shown.

a b COPD was spirometrically defined as FEV1/FVC<0.7 and FEV1 < 80% predicted. COPD GOLD 1-4 was defined as FEV1/FVC<0.7

The Z allele is strongly associated with height

Heterozygosity for the Z allele was strongly associated with height (β = 1.02 cm, P = 3.91x10-68 –

Table 2) and, when lung function measures were not adjusted for height, the Z allele heterozygosity

-19 had much larger effect estimates for FEV1 (β = 44.72 ml [SE 4.97], P = 2.20x10 ) and FVC (β = 61.06

-23 ml [SE 6.18], P = 5.18x10 ), but not FEV1/FVC. These results suggest that carrying one copy of the Z allele confers an advantage primarily (but not entirely) driven by increased height. To investigate the developmental stage at which Z allele heterozygosity influences height, we tested association with height in the ALPSAC cohort at ages 8, 15 and 24 years. The findings were consistent with Z allele heterozygosity influencing height from adolescence and, at all the ages, directions of effect on height and lung function were consistent with those in UK Biobank (S5 Table).

Sex modifies the effect of Z allele heterozygosity on lung function

We also assessed whether sex can modify the effect of the Z allele on lung function or height and

found that heterozygosity for the Z allele was associated with higher height-adjusted FEV1/FVC in females (β = 0.0028 [SE 0.00071], P = 5.89x10-5) but not in males (β = -0.0015 [SE 0.0009], P = 0.093)

(Z allele*sex interaction: P = 0.00021 for FEV1/FVC, S4 Table and S6 Table).

Association between Z allele homozygosity and lung function

In contrast to the lung function raising effects of carrying one copy of the Z allele, homozygosity for the Z allele has been widely reported to reduce lung function and increase risk of COPD. Similarly,

UK Biobank individuals homozygous for the Z allele had significantly lower FEV1 (β = -249.21 ml, P =

6.96x10-7), FEV1/FVC (β = -0.051, P = 3.54x10-16) and FVC (β = -132.16, P = 0.028) compared to wild- type and heterozygous individuals and greater risk of COPD (both moderate-severe COPD, OR = 7.42,

P = 5.67x10-14, and COPD GOLD 1-4, OR = 4.58, P = 8.67x10-12) (Table 2). The associations between homozygosity for the Z allele and reduced lung function and increased risk of COPD were stronger in smokers compared to non-smokers (Table 2). Given the strength of these associations, it is

interesting to note that 58 of 93 individuals homozygous for the Z allele do not have spirometrically-

defined COPD (FEV1/FVC<0.7) and four out of 15 homozygous ever-smokers aged over 60 do not have spirometrically-defined COPD. We generated polygenic risk scores for lower FEV1/FVC by weighting variants according to beta-coefficients in the SpiroMeta consortium cohorts[19]. The 58 individuals homozygous for the Z allele but without COPD have an average score percentile of 47.6 compared to 57.0 in those with COPD. This suggests that individuals homozygous for the Z allele but without COPD may have a more protective genetic profile across other genomic loci.

Diagnosis of AATD in individuals homozygous for the Z allele

We note that only 20 of 141 individuals who were genotyped ZZ homozygotes in the full UK Biobank cohort had a recorded ICD-10 coding for AATD (E880) in Hospital Episode Statistics. As this could indicate miscoding rather than misdiagnosis, we investigated further in subset of 65 homozygotes with linked primary care data. Of these 65 ZZ homozygotes, 15 had primary care (Read) codes or

ICD-10 codes for AATD and 50 did not. Of the group without AATD codes, four had primary care

(Read) codes or ICD-10 codes for bronchiectasis and an additional 6 had primary care (Read) codes or ICD-10 codes for COPD indicating potential misdiagnosis of AATD.

Discussion

We describe novel phenotypic associations of heterozygosity for the Z allele of SERPINA1 from a

PheWAS of UK Biobank, and also present definitive evidence that heterozygosity for the Z allele is associated with greater FEV1 and FEV1/FVC only in non-smokers. Our findings have implications for individuals heterozygous for the SERPINA1 Z allele, and more generally for the study of rare variants and gene-environment interactions.

Our PheWAS examining the consequences of carrying one copy of the SERPINA1 Z allele revealed potentially important associations with non-respiratory traits and diseases. Consistent with previous reports[12], we detected a very strong association between Z allele heterozygosity and height (with each additional Z allele adding approximately 1cm to height). The mechanism and timing of the effect of the Z allele on height is not understood. Our findings in the ALSPAC study suggest a possible influence of Z allele heterozygosity on height which is manifest from puberty, although results should be interpreted with caution given the limitations in power in ALSPAC alone. This suggests that sex hormones are a possible mediator of the height-raising effects of the Z allele and, indeed, we detected higher levels of testosterone in individuals heterozygous for the Z allele.

However, heterozygosity for the Z allele is associated with increased height in males and females, whereas increased testosterone is only seen in males. Furthermore, Z allele heterozygotes also exhibit higher SHBG suggesting that the amount of free testosterone will be unchanged. IGF-I levels relate to height, but in our study the magnitude of the association was very small (less than 1% average levels) and it was a negative association. It is therefore still not clear why heterozygosity and homozygosity for the Z allele is associated with increased height.

We detected strong associations between heterozygosity for the Z allele and increased risk of gall stones and gall bladder removal. This is consistent with recent reports that the Z allele may be a risk factor for developing gallstone disease[21, 22]. The mechanism underlying this association is unclear but previous reports have suggested it may be related to liver dysfunction in AATD and/or

the composition of bile[21, 22]. We found that individuals heterozygous for the Z allele also had increased levels of alkaline phosphatase (ALP), which is characteristic of liver disease and biliary tract obstruction due to gallstones. Moreover, the Z allele is associated with elevation of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Higher than normal levels of ALT and

AST are hallmarks of liver disease, and are also observed in some patients with gallbladder disease[23]. Higher bilirubin, another potential sign of liver disease, is also exhibited by Z allele carriers. Interestingly, excess bilirubin is thought to contribute to gallstone formation[24], so a causal pathway between the Z allele, liver dysfunction and gallbladder problems is possible.

Heterozygosity for the Z allele was also associated with musculoskeletal phenotypes such as reduced risk of osteoarthritis, increased risk of osteoporosis and lower bone mineral density. Calcium was increased in heterozygotes but, as albumin was also increased, free calcium may not be different in this group. A recent study showed that AAT can inhibit receptor activator of nuclear factor κ-B ligand (RANKL)-induced osteoclast formation and bone resorption[25]. As heterozygosity for the Z allele causes reduction in AAT, individuals heterozygous for the Z allele may have increased risk of osteoporosis and lower bone mineral density due to increased RANKL-induced bone resorption.

Lower bone mineral density has been associated with a lower risk of osteoarthritis[26, 27].

Heterozygotes for the Z allele also had reduced risk of heart disease (even when adjusted for height) and lower blood pressure, as well as increased risk of headache consistent with one previous report suggesting cluster headaches may be more frequent in heterozygotes for the Z allele[6]. There was also a marked association between heterozygosity and reduced reticulocyte count and reticulocyte percentage which, as far as we are aware, has not been reported previously.

Homozygosity for the Z allele was strongly associated with self-reported/HES recorded alpha 1 antitrypsin deficiency and respiratory traits, but also haemoglobin concentration and haematocrit percentage, which may be driven by the associations with respiratory disease. Homozygosity was also associated with markedly higher risk of optic neuritis and pancreatitis. These associations

should be interpreted with care, especially the association with optic neuritis, as small case-numbers may have resulted in poor estimation of effect sizes.

Whilst homozygosity for the Z allele is an established cause of respiratory disease, the effect of heterozygosity on respiratory health of general populations has been less clear. Our study provides definitive data on the effects of heterozygosity for the Z allele on respiratory traits, showing that heterozygosity is associated with greater lung function in never-smokers (even after height adjustment), but not in smokers. Our results contrast with previous studies[8-11] that did not detect higher lung function in participants heterozygous for the Z allele compared to wild-type, and with studies that did not detect differential effects by smoking status[12]. There are several possible reasons for these discrepancies. First, the relatively low frequency of the Z allele meant previous studies were underpowered. Our study contained 18 times more heterozygous participants than the previous largest population-based study and 46 times more than the largest case-control study.

Whilst one previous study has suggested a beneficial effect of Z allele heterozygosity on lung function[12] it nevertheless did not detect differential effects by smoking status. Again, this is probably due to power. Second, most of the previous studies were conducted in current and former smokers only[8, 9, 11], and would therefore have missed the effect of Z allele heterozygosity in non- smokers. Third, most previous studies recruited participants on the basis of their health status (as in case-control studies[8, 9]) or the health status of a family member[10, 11, 28]. These approaches can lead to ascertainment biases that might distort causal estimates. A major strength of using the

UK Biobank for our study was that participants were not ascertained on the basis of having lung disease, enabling a relatively unbiased assessment of the role of the heterozygosity for the Z allele in lung function. It should be noted, however, that UK Biobank participants tend to be healthier and more highly educated than the UK population as a whole, so detrimental effects of the Z allele may be less pronounced in UK Biobank due to fewer lifestyle risk factors. Fourth, the Z allele is not present on most standard genotyping arrays and therefore high quality imputation is required to detect its effects. Furthermore, genetic studies tend to focus on the additive genetic model rather

than heterozygous or recessive models. Because we designed the Z allele into the UK Biobank array[17] and compared different genetic models, we were able to robustly examine this association in UK Biobank participants.

The biological mechanism underlying the association between heterozygosity for the Z allele and increased lung function in non-smokers is not clear. The SERPINA1 gene encodes alpha 1 antitrypsin

(AAT), a glycoprotein with an important role in inhibiting proteases, such as neutrophil elastase, which are secreted during inflammation and cause collateral tissue damage. The Z allele produces

AAT with reduced anti-protease activity and a propensity to form polymers, which accumulate in liver thereby reducing the circulating levels of AAT. The polymers themselves have also been shown to be a pro-inflammatory stimulus in lung tissue[29] which further perpetuates lung inflammation and damage. Homozygosity for the Z allele is the most common cause of severe AAT deficiency whereas heterozygosity for the Z allele has been shown to result in intermediate levels of AAT (~60% of normal)[30]. One might therefore expect heterozygosity to have, if anything, a detrimental effect on lung function. There is evidence that positive selection has acted at the Z allele locus[12, 31] and mechanisms of heterozygous advantage (through increased height[12] and protection from infectious respiratory diseases by promotion of inflammatory responses[31]) have been proposed.

The amplification of inflammatory response as a result of cigarette smoke may therefore provide a mechanism for eliminating this advantage in smokers. It has also been shown that smoking-induced oxidative modifications to AAT reduce its ability to inhibit neutrophil elastase and turn it into a pro- inflammatory mediator[32]. Cigarette smoke has been found to accelerate polymerisation of Z-type

AAT[33], suggesting a possible mechanism whereby smoking may modify the effect of the Z allele on lung function.

We also report a novel interaction between sex and the SERPINA1 Z allele heterozygosity on

FEV1/FVC. Women heterozygous for the Z allele exhibited greater FEV1/FVC compared to wild-type, whereas men heterozygous for the Z allele showed no significant difference to wild-type. Previous

studies have shown that individuals with the fastest decline in lung function amongst AATD patients are more likely to be male[15]. However, the reasons why sex would appear to modify the effect of

Z allele heterozygosity on lung function are not clear.

Finally, we confirm that homozygosity for the Z allele is associated with reduced lung function and increased risk of COPD and that these effects are exacerbated by smoking. These results are consistent with a recently published study in UK Biobank focused on homozygosity for the Z allele

[34]. Also consistent with the Nakanishi et al. paper, we show that only a minority of individuals with the ZZ genotype have been diagnosed with AATD (as has been reported elsewhere[35, 36]) , and that those without a diagnosis of AATD, bronchiectasis or COPD have a protective genetic profile at other known lung function loci.

In conclusion, we have demonstrated that heterozygosity for the Z allele is associated with previously unrecognised non-respiratory phenotypes. Further studies will be required to confirm findings in independent populations, produce accurate effect estimates, to understand the causal pathways involved, and the potential role of genetic and environmental modifiers. We have also shown that heterozygosity for the Z allele is associated with greater lung function in non-smokers.

Our results demonstrate that large sample sizes are required to study the effects of rare variants, particularly when these effects depend on an environmental stimulus. The opposing directions of effect of Z allele heterozygosity and homozygosity on lung function demonstrate that the additive genetic model is not always appropriate for genetic studies of the rarer variants such as the

SERPINA1 Z allele. Our findings suggest that while individuals who are heterozygous for the Z allele may not exhibit symptoms of AAT deficiency, they may be more susceptible to smoking-induced lung disease and have altered risk of other non-respiratory conditions.

Acknowledgements

The UK Biobank analysis was conducted under approved UK Biobank data application number 648 and application number 20361. We thank UK Biobank and all the participants for generating this important health research resource. This study used the ALICE and SPECTRE High Performance

Computing Facilities at the University of Leicester. We are extremely grateful to all the families who took part in the ALSPAC study, the midwives for their help in recruiting them, and the whole

ALSPAC team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists and nurses.

Funding

The data for this study were partially generated by Medical Research Council (MRC) strategic award to M.D.T., I.P.H., and L.V.W. (MC_PC_12010). The research was partially supported by the NIHR

Nottingham Biomedical Research Centre; the views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. M.D.T. is supported by a

Wellcome Trust Investigator Award (WT202849/Z/16/Z). M.D.T. and L.V.W. have been supported by the MRC (MR/N011317/1). L.V.W. holds a GSK/British Lung Foundation Chair in Respiratory

Research. K.A.F. holds an Asthma UK fellowship award. I.P.H. holds a NIHR Senior Investigator award. C.J. holds a Medical Research Council Clinical Research Training Fellowship (MR/P00167X/1).

We would like to acknowledge the support of the Health Data Research UK BREATHE Digital

Innovation Hub funded by URKI (MC_PC_19004). The UK Medical Research Council and Wellcome

(Grant ref: 102215/2/13/2) and the University of Bristol provide core support for the Avon

Longitudinal Study of Parents and Children (ALSPAC). This publication is the work of the authors and

Raquel Granell will serve as guarantor for the contents of this paper. A comprehensive list of grants funding is available on the ALSPAC website

(http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf. N.J.T. is a

Wellcome Trust Investigator (202802/Z/16/Z), is the PI of ALSPAC (MRC & WT 217065/Z/19/Z), is

supported by the University of Bristol NIHR Biomedical Research Centre (BRC-1215-2001), the MRC

Integrative Epidemiology Unit (MC_UU_00011) and works within the CRUK Integrative Cancer

Epidemiology Programme (C18281/A19169).

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Fig. 1. Traits associated with the SERPINA1 Z allele in UK Biobank. Traits displayed are those with a false discovery rate<0.01 from phenome-wide association study of 2411 phenotypes across 379101

UK Biobank participants using the heterozygous model for the Z allele (wild-type vs heterozygous individuals) (A) and the recessive model for the Z allele (wild-type and heterozygous individuals vs individuals homozygous for the Z allele) (B).

Online Data Supplement

Pleiotropic associations of heterozygosity for the SERPINA1 Z allele in the UK Biobank

Katherine A Fawcett, Kijoung Song, Guoqing Qian, Aliki-Eleni Farmaki, Richard Packer, Catherine

John, Nick Shrine, Raquel Granell, Sue Ring, Nicholas J Timpson, Laura M Yerges-Armstrong, Richard

Eastell, Louise V Wain, Robert A Scott, Martin D Tobin, Ian P Hall

Supplemental Subjects and Methods

ALSPAC study: original cohort description

Pregnant women resident in Avon, UK with expected dates of delivery 1st April 1991 to 31st

December 1992 were invited to take part in the study. The initial number of pregnancies enrolled is

14,541 (for these at least one questionnaire has been returned or a “Children in Focus” clinic had been attended by 19/07/99). Of these initial pregnancies, there was a total of 14,676 foetuses, resulting in 14,062 live births and 13,988 children who were alive at 1 year of age.

When the oldest children were approximately 7 years of age, an attempt was made to bolster the initial sample with eligible cases who had failed to join the study originally. As a result, when considering variables collected from the age of seven onwards (and potentially abstracted from obstetric notes) there are data available for more than the 14,541 pregnancies mentioned above.

The number of new pregnancies not in the initial sample (known as Phase I enrolment) that are currently represented on the built files and reflecting enrolment status at the age of 24 is 913 (456,

262 and 195 recruited during Phases II, III and IV respectively), resulting in an additional 913 children being enrolled. The phases of enrolment are described in more detail in the cohort profile paper and its update. The total sample size for analyses using any data collected after the age of seven is therefore 15,454 pregnancies, resulting in 15,589 foetuses. Of these 14,901 were alive at 1 year of age.

A 10% sample of the ALSPAC cohort, known as the Children in Focus (CiF) group, attended clinics at the University of Bristol at various time intervals between 4 to 61 months of age. The CiF group were chosen at random from the last 6 months of ALSPAC births (1432 families attended at least one clinic). Excluded were those mothers who had moved out of the area or were lost to follow-up, and those partaking in another study of infant development in Avon.

Ethical approval for the study was obtained from the ALSPAC Ethics and Law Committee and the

Local Research Ethics Committees. Further details are available in the cohort profile papers[1-3].

Study data were collected and managed using REDCap electronic data capture tools[4, 5] hosted at

University of Bristol. The study website contains details of all the data that is available through a fully searchable data dictionary and variable search tool: http://www.bristol.ac.uk/alspac/researchers/our-data/

Informed consent for the use of data collected via questionnaires and clinics was obtained from participants following the recommendations of the ALSPAC Ethics and Law Committee at the time.

ALSPAC study: data collection

Outcome 1: Height

Longitudinal measurements of height were obtained from direct measurement in research clinics at age at 8, 15 and 24 years. Standing height was measured to the last complete millilitre by trained clinic staff.

Outcome 2: Lung function Data

Spirometry was performed according to ATS/ERS criteria[6, 7] by trained fieldworkers in a research clinic at ages 8, 15 and 24 years. All flow-volume curves were inspected post hoc for quality assurance. Lung function at ages 15 and 24 years were measured before and 15 minutes after receiving 400 µg of salbutamol[8, 9]. The highest measurement of each lung function parameter,

FVC, FEV1, forced expiratory flow, mid-expiratory phase (FEF25-75), amongst the best three technically acceptable flow-volume curves was used for analyses. Post-bronchodilator lung function variables were used at age 15 and 24 years. Standardised scores (SD-scores) adjusted for sex, age and height at lung function clinic, were used as the lung function outcomes.

PheWAS: overview of study design

Our phenome-wide association study (pheWAS) in UK Biobank tests association between a single genetic variant (the SERPINA1 Z allele) and a broad range of phenotypic traits available in UK

Biobank participants, including those derived from direct measurement such as height, weight, and blood biomarkers, to health conditions self-reported at an assessment centre visit or from hospital inpatient records, also called hospital episode statistics (HES) data. We used logistic regression models to test association between the Z allele and binary health outcomes, and linear regression models to test association between the Z allele and continuous traits. We used minimal adjustments for covariates in order that analyses did not inadvertently adjust for intermediates on a causal pathway or induce collider bias[10]. These models therefore included (i) age, (ii) sex, (iii) genotyping array to account for the two different genotyping arrays used to measure genetic variation in UK

Biobank participants, and (iv) ancestry-based principal components to account for fine-scale population structure within UK Biobank participants of European ancestry.

Supplemental References

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Table S1. Frequency of the SERPINA1 Z allele in 411,002 unrelated European UK Biobank participants

Sex Smoking status Age group MM MZ ZZ N M Z O(MM) E(MM) O(MZ) E(MZ) O(ZZ) E(ZZ) Chi-squared P All All 394674 16199 129 411002 0.979979 0.020021 394674 394709.7 16199 16127.52 129 164.7394 8.073513332 0.004 Ever-smokers All 180774 7264 47 188085 0.98044 0.01956 180774 180799 7264 7214.075 47 71.96236 9.007913227 0.003 Never-smokers All 213900 8935 82 222917 0.979591 0.020409 213900 213910.9 8935 8913.299 82 92.85048 1.321368824 0.250 40-59 years 219339 8852 76 228267 0.980277 0.019723 219339 219351.8 8852 8826.418 76 88.79078 1.917466848 0.166 All All 60+ years 175335 7347 53 182735 0.979607 0.020393 175335 175358 7347 7301.012 53 75.99421 7.2502453 0.007 40-59 years 92580 3664 23 96267 0.980731 0.019269 92580 92592.74 3664 3638.511 23 35.7446 4.724351694 0.030 Ever-smokers 60+ years 88194 3600 24 91818 0.980135 0.019865 88194 88206.23 3600 3575.531 24 36.23446 4.300080537 0.038 40-59 years 126759 5188 53 132000 0.979947 0.020053 126759 126759.1 5188 5187.839 53 53.08037 0.000126725 0.991 Never-smokers 60+ years 87141 3747 29 90917 0.979074 0.020926 87141 87151.81 3747 3725.378 29 39.81111 3.06270122 0.080 All All 182549 7409 64 190022 0.980168 0.019832 182549 182559.7 7409 7387.527 64 74.73657 1.605449841 0.205 Ever-smokers All 96014 3850 26 99890 0.980469 0.019531 96014 96026.11 3850 3825.788 26 38.10593 4.000702309 0.045 Males Never-smokers All 86535 3559 38 90132 0.979835 0.020165 86535 86533.65 3559 3561.701 38 36.64965 0.051822323 0.820 40-59 years 98442 3880 33 102355 0.980724 0.019276 98442 98447.03 3880 3869.937 33 38.03164 0.6921198 0.405 All 60+ years 84107 3529 31 87667 0.979519 0.020481 84107 84112.77 3529 3517.453 31 36.77348 0.944743965 0.331 All All 212125 8790 65 220980 0.979817 0.020183 212125 212150 8790 8739.969 65 90.01539 7.241150451 0.007 Ever-smokers All 84760 3414 21 88195 0.980407 0.019593 84760 84772.86 3414 3388.287 21 33.85661 5.079217263 0.024 Females Never-smokers All 127365 5376 44 132785 0.979425 0.020575 127365 127377.2 5376 5351.58 44 56.20984 2.764808602 0.096 40-59 years 120897 4972 43 125912 0.979915 0.020085 120897 120904.8 4972 4956.408 43 50.79612 1.246091786 0.264 All 60+ years 91228 3818 22 95068 0.979688 0.020312 91228 91245.22 3818 3783.556 22 39.22204 7.878858049 0.005 40-59 years 45844 1762 9 47615 0.981308 0.018692 45844 45851.64 1762 1746.729 9 16.63551 3.639395806 0.056 Ever-smokers 60+ years 50170 2088 17 52275 0.979703 0.020297 50170 50174.53 2088 2078.931 17 21.5346 0.994835197 0.319 Males 40-59 years 52598 2118 24 54740 0.980216 0.019784 52598 52595.43 2118 2123.147 24 21.42654 0.321690548 0.571 Never-smokers 60+ years 33937 1441 14 35392 0.979247 0.020753 33937 33938.24 1441 1438.513 14 15.24328 0.105749132 0.745 40-59 years 46736 1902 14 48652 0.980165 0.019835 46736 46741.14 1902 1891.719 14 19.14053 1.437020728 0.231 Ever-smokers 60+ years 38024 1512 7 39543 0.980705 0.019295 38024 38031.72 1512 1496.555 7 14.72243 4.211647147 0.040 Females 40-59 years 74161 3070 29 77260 0.979757 0.020243 74161 74163.66 3070 3064.679 29 31.66057 0.232914036 0.629 Never-smokers 60+ years 53204 2306 15 55525 0.978964 0.021036 53204 53213.57 2306 2286.861 15 24.56955 3.88912281 0.049 Table S2. Phenome-wide association study results for SERPINA1 Z allele heterozygosity in UK Biobank

Category Phenotype Effect allele N Cases Controls OR Beta SE L95 U95 P FDR Anthropometry Standing height T 378103 NA NA NA 0.154838 0.008263 0.138642 0.171034 2.42E-78 5.84E-75 Operations and Procedures Gall bladder removal (self-reported) T 378957 14872 364229 1.51 0.412834 0.036632 1.41 1.62 1.85E-29 2.23E-26 Respiratory Alpha1 antitrypsin deficiency (HES and self-reported) T 378957 223 378878 5.82 1.76184 0.176835 4.12 8.24 2.21E-23 1.77E-20 Biological assays High light scatter reticulocyte percentage T 361631 NA NA NA -0.07962 0.008511 -0.0963 -0.06293 8.41E-21 5.07E-18 Biological assays High light scatter reticulocyte count T 361630 NA NA NA -0.07841 0.008514 -0.0951 -0.06173 3.26E-20 1.57E-17 Biological assays Reticulocyte percentage T 361630 NA NA NA -0.07775 0.008515 -0.09443 -0.06106 6.82E-20 2.74E-17 Respiratory FVC maximumValue T 286064 NA NA NA 0.086208 0.009563 0.067463 0.104952 1.98E-19 6.82E-17 Biological assays Reticulocyte count T 361630 NA NA NA -0.07516 0.008517 -0.09185 -0.05847 1.09E-18 3.29E-16 Respiratory FVC maximumValue strict* T 221584 NA NA NA 0.092784 0.010876 0.071467 0.114101 1.45E-17 3.88E-15 Respiratory FEV1 maximumValue T 286064 NA NA NA 0.079709 0.009571 0.06095 0.098468 8.21E-17 1.98E-14 Digestive system Gall stones (HES and self-reported) T 378957 16555 362546 1.35 0.298659 0.036235 1.26 1.45 1.69E-16 3.70E-14 Respiratory FEV1 maximumValue strict T 221584 NA NA NA 0.088488 0.010886 0.067152 0.109823 4.33E-16 8.70E-14 Respiratory PEF maximumValue T 286064 NA NA NA 0.073969 0.009581 0.055189 0.092748 1.16E-14 2.15E-12 Family history Heart disease (family history) T 378957 NA NA NA -0.06269 0.008312 -0.07898 -0.0464 4.63E-14 7.96E-12 Respiratory PEF maximumValue strict T 221584 NA NA NA 0.077439 0.0109 0.056074 0.098803 1.21E-12 1.94E-10 Family history Chronic bronchitis emphysema (family history - father) T 343458 37574 306018 1.19 0.176499 0.026529 1.13 1.26 2.87E-11 4.32E-09 Anthropometry Whole body fat free mass T 372298 NA NA NA 0.055154 0.008368 0.038752 0.071555 4.37E-11 6.19E-09 Anthropometry Whole body water mass T 372328 NA NA NA 0.055014 0.008368 0.038611 0.071416 4.90E-11 6.54E-09 Respiratory FEV1 never smoked only T 109805 NA NA NA 0.10136 0.015436 0.071105 0.131615 5.16E-11 6.54E-09 Cardiovascular Systolic blood pressure mean T 357107 NA NA NA -0.05519 0.008538 -0.07192 -0.03846 1.02E-10 1.23E-08 Metabolic Other metabolic disorders (HES) T 378957 309 378792 3.18 1.15769 0.182869 2.22 4.55 2.44E-10 2.80E-08 Respiratory FEV1 never smoked only strict T 84245 NA NA NA 0.11129 0.017603 0.076789 0.145791 2.58E-10 2.82E-08 Cardiovascular Diastolic blood pressure mean T 357110 NA NA NA -0.05215 0.008539 -0.06889 -0.03541 1.01E-09 1.06E-07 Biological assays Immature reticulocyte fraction T 361630 NA NA NA -0.05186 0.008503 -0.06852 -0.03519 1.07E-09 1.07E-07 Family history Heart disease (family history - father) T 343458 109130 234462 0.89 -0.11598 0.019175 0.858 0.925 1.46E-09 1.41E-07 Summary Disorders of gallbladder biliary tract and pancreas (HES) T 378957 16365 362736 1.25 0.220686 0.037509 1.16 1.34 4.02E-09 3.72E-07 Neurosciences Headache T 378087 81591 296640 1.12 0.116486 0.019992 1.08 1.17 5.66E-09 5.05E-07 Respiratory FEV1 ever smoked only T 175212 NA NA NA 0.069583 0.012235 0.045603 0.093562 1.29E-08 1.11E-06 Respiratory FEV1 ever smoked only strict T 136671 NA NA NA 0.07772 0.013884 0.050508 0.104932 2.17E-08 1.80E-06 Neurosciences Headaches for 3 months vs no pain T 330405 33891 296640 1.17 0.154784 0.02832 1.1 1.23 4.61E-08 3.71E-06 Digestive system Bile duct disease (HES and self-reported) T 378957 13856 365245 1.25 0.220425 0.040543 1.15 1.35 5.42E-08 4.21E-06 Genitourinary Enlarged prostate (HES and self-reported) T 378957 13062 366039 1.26 0.228012 0.043815 1.15 1.37 1.95E-07 1.47E-05 Musculoskeletal Grip strength maximumValue T 378178 NA NA NA 0.041545 0.008305 0.025266 0.057824 5.67E-07 4.14E-05 Digestive system Cholelithiasis (HES) T 378957 12988 366113 1.23 0.209588 0.041986 1.14 1.34 5.98E-07 4.24E-05 Anthropometry Weight T 377835 NA NA NA 0.04066 0.008326 0.02434 0.05698 1.04E-06 7.18E-05 Musculoskeletal Osteoarthritis knee or hip T 339483 27422 312194 0.845 -0.16799 0.03457 0.79 0.905 1.18E-06 7.88E-05 Family history Heart disease (family history - mother) T 357389 69487 288042 0.898 -0.10794 0.022461 0.859 0.938 1.54E-06 9.94E-05 Digestive system Gall bladder disease (HES and self-reported) T 378957 13958 365143 1.22 0.195992 0.040812 1.12 1.32 1.57E-06 9.94E-05 Operations and Procedures Saphenous vein graft replacement of coronary artery T 378957 3223 375878 0.582 -0.54089 0.116223 0.464 0.731 3.26E-06 0.000201 Summary Arthrosis (HES) T 378957 40307 338794 0.876 -0.13213 0.02855 0.829 0.927 3.69E-06 0.000217 Respiratory Emphysema (HES) T 378957 1571 377530 1.63 0.48683 0.105085 1.32 2 3.61E-06 0.000217 Operations and Procedures Connection of thoracic artery to coronary artery T 378957 3408 375693 0.607 -0.49996 0.110758 0.488 0.754 6.36E-06 0.000365 Cardiovascular Chronic ischaemic heart disease (HES) T 378957 22951 356150 0.842 -0.17163 0.038103 0.782 0.908 6.66E-06 0.000373 Respiratory Emphysema (HES and self-reported) T 378957 1662 377439 1.58 0.458595 0.103436 1.29 1.94 9.27E-06 0.000507 Musculoskeletal Carpal tunnel syndrome (HES and self-reported) T 378957 9101 370000 0.764 -0.26947 0.060982 0.678 0.861 9.92E-06 0.000531 Family history Diabetes (family history - mother) T 357389 32382 325147 0.871 -0.1384 0.031439 0.819 0.926 1.07E-05 0.000562 Musculoskeletal Arthritis nos (HES and self-reported) T 378957 13143 365958 0.804 -0.21859 0.05 0.729 0.886 1.23E-05 0.000631 Cardiovascular Heartcardiac problem (HES and self-reported) T 378957 25675 353426 0.855 -0.15622 0.035911 0.797 0.918 1.36E-05 0.000683 Musculoskeletal BMD Combined T 338046 NA NA NA -0.03816 0.008784 -0.05537 -0.02094 1.40E-05 0.000689 Operations and Procedures Release of entrapment of peripheral nerve at wrist T 378957 8745 370356 0.765 -0.26734 0.06217 0.678 0.865 1.71E-05 0.000822 Family history Chronic bronchitis emphysema (family history - mother) T 357389 20553 336976 1.16 0.145529 0.0349 1.08 1.24 3.05E-05 0.00144 Medication Drugs used in benign prostatic hypertrophy T 378957 6797 372304 1.26 0.231243 0.057487 1.13 1.41 5.76E-05 0.002667 ENT Tonsillectomy adenoids (self-reported) T 378957 59321 319780 0.91 -0.09411 0.023631 0.869 0.953 6.82E-05 0.00304 Musculoskeletal Osteoarthritis knee T 330283 18217 312194 0.847 -0.16603 0.041654 0.781 0.919 6.72E-05 0.00304 Neurosciences Migraine (HES and self-reported) T 378957 12905 366196 1.18 0.168248 0.042774 1.09 1.29 8.38E-05 0.003669 Medication Calcium T 378957 6050 373051 1.26 0.232247 0.060435 1.12 1.42 0.000122 0.005208 Musculoskeletal Osteoarthritis all T 370576 58523 312194 0.911 -0.09284 0.024179 0.869 0.956 0.000123 0.005208 Operations and Procedures Plastic operations on nose T 378957 781 378320 1.74 0.553883 0.145181 1.31 2.31 0.000136 0.005653 Musculoskeletal Osteoarthritis (HES and self-reported) T 378957 58523 320578 0.914 -0.09013 0.024107 0.872 0.958 0.000185 0.007556 Summary Ischaemic heart diseases (HES) T 378957 27652 351449 0.88 -0.12728 0.034354 0.823 0.942 0.000211 0.00835 Genitourinary Hyperplasia of prostate (HES) T 378957 10244 368857 1.2 0.182831 0.049299 1.09 1.32 0.000208 0.00835 Musculoskeletal Gonarthrosis (HES) T 378957 18217 360884 0.859 -0.15248 0.041427 0.792 0.931 0.000233 0.009034 Operations and Procedures Excision of gall bladder T 378957 12079 367022 1.18 0.161564 0.044348 1.08 1.28 0.000269 0.010301 Neurosciences Trapped nervecompressed nerve (HES and self-reported) T 378957 15824 363277 0.851 -0.16133 0.044443 0.78 0.928 0.000283 0.010665 Anthropometry Body mass index BMI T 377691 NA NA NA -0.03011 0.008325 -0.04643 -0.01379 0.000299 0.011072 Digestive system Pancreatitis (HES and self-reported) T 378957 2304 376797 1.4 0.333003 0.092432 1.16 1.67 0.000315 0.011496 Digestive system Pancreatic disease (HES and self-reported) T 378957 2413 376688 1.38 0.323164 0.090644 1.16 1.65 0.000364 0.013036 Musculoskeletal Disc problem (HES and self-reported) T 378957 8039 371062 0.797 -0.22742 0.063845 0.703 0.903 0.000368 0.013036 Operations and Procedures Diagnostic percutaneous operations on liver T 378957 1755 377346 1.45 0.370142 0.104367 1.18 1.78 0.00039 0.013432 Operations and Procedures Endoscopic incision of sphincter of Oddi T 378957 1801 377300 1.44 0.364936 0.102888 1.18 1.76 0.00039 0.013432 Family history Chronic bronchitis emphysema (family history) T 378957 NA NA NA 0.029214 0.008303 0.01294 0.045489 0.000434 0.014728 Metabolic Disorders of lipoprotein metabolism and other lipidaemias (HES) T 378957 32636 346465 0.896 -0.10962 0.031424 0.843 0.953 0.000486 0.016256 Summary Diseases of male genital organs (HES) T 378957 17819 361282 1.14 0.135365 0.039117 1.06 1.24 0.000539 0.017258 Operations and Procedures Contrast radiology of heart T 378957 21382 357719 0.875 -0.13354 0.038527 0.811 0.944 0.000528 0.017258 Respiratory Spontaneous pneumothoraxrecurrent pneumothorax (HES and self-reported) T 378957 1034 378067 1.58 0.454489 0.131436 1.22 2.04 0.000544 0.017258 Other Sleeplessness insomnia T 378457 NA NA NA -0.02881 0.008317 -0.04511 -0.01251 0.000532 0.017258 Musculoskeletal Other intervertebral disc disorders (HES) T 378957 6634 372467 0.785 -0.24172 0.070648 0.684 0.902 0.000623 0.019484 NA Myocardial infarction T 378957 13488 365613 0.848 -0.16431 0.048807 0.771 0.934 0.000761 0.023504 Genitourinary Bph benign prostatic hypertrophy (HES and self-reported) T 378957 10618 368483 1.18 0.16393 0.04886 1.07 1.3 0.000793 0.024194 Digestive system Liver failurecirrhosis (HES and self-reported) T 378957 1525 377576 1.45 0.374481 0.112064 1.17 1.81 0.000833 0.025075 Musculoskeletal Other arthritis (HES) T 378957 10538 368563 0.834 -0.1812 0.054875 0.749 0.929 0.00096 0.028554 Cardiovascular Angina pectoris (HES) T 378957 16491 362610 0.866 -0.14425 0.043835 0.794 0.943 0.000999 0.029355 Cardiovascular Pulse minimumValue T 357110 NA NA NA -0.02796 0.008539 -0.04469 -0.01122 0.00106 0.030777 Musculoskeletal Osteoporosis (HES and self-reported) T 378957 10107 368994 1.17 0.159544 0.048989 1.07 1.29 0.001127 0.032319 Medication Drugs affecting bone structure and mineralization T 378957 7218 371883 1.2 0.181067 0.056898 1.07 1.34 0.001461 0.041404 Medication Beta blocking agents and other diuretics T 378957 15555 363546 0.868 -0.1416 0.044758 0.795 0.948 0.001557 0.043123 Family history Diabetes (family history - father) T 343458 31628 311964 0.905 -0.09947 0.031424 0.851 0.963 0.001548 0.043123 Neurosciences Mononeuropathies of upper limb (HES) T 378957 9665 369436 0.836 -0.17927 0.056892 0.748 0.934 0.001627 0.044096 Gynaecology and Obstetrics Age at menopause last menstrual period T 116920 NA NA NA 0.046685 0.014818 0.017643 0.075728 0.001629 0.044096 Summary Inflammatory polyarthropathies (HES) T 378957 17341 361760 0.876 -0.13225 0.042244 0.807 0.952 0.001745 0.045326 Cancer Mal neo breast (cancer register) T 378957 10158 368943 0.839 -0.17511 0.055951 0.752 0.937 0.00175 0.045326 Summary Mal neoplasm of breast (cancer register) T 378957 10158 368943 0.839 -0.17511 0.055951 0.752 0.937 0.00175 0.045326 Operations and Procedures Other division of bone T 378957 1162 377939 1.48 0.393026 0.125388 1.16 1.89 0.001722 0.045326 Mental health Neuroticism score T 307154 NA NA NA -0.02879 0.009216 -0.04685 -0.01073 0.001784 0.045714 Medication Beta blocking agents and thiazides T 378957 27196 351905 0.899 -0.10597 0.033968 0.842 0.961 0.001811 0.045923 Neurosciences Peripheral nerve disorder (HES and self-reported) T 378957 16736 362365 0.876 -0.1329 0.042732 0.805 0.952 0.00187 0.046934 Musculoskeletal Tendonitis tendinitis tenosynovitis (HES and self-reported) T 378957 5613 373488 0.789 -0.23754 0.076472 0.679 0.916 0.001895 0.04706 Cardiovascular Angina (HES and self-reported) T 378957 20423 358678 0.887 -0.12035 0.039335 0.821 0.958 0.002216 0.05447 Digestive system Acute pancreatitis (HES) T 378957 1763 377338 1.38 0.322185 0.105892 1.12 1.7 0.002346 0.056035 Symptoms Abnormal results of function studies (HES) T 378957 3857 375244 1.26 0.228606 0.075147 1.08 1.46 0.002349 0.056035 Gynaecology and Obstetrics Caesarean section caesarian section (self-reported) T 378957 19341 359760 0.884 -0.12358 0.040609 0.816 0.957 0.002341 0.056035 Anthropometry Whole body fat mass T 371710 NA NA NA 0.025445 0.008395 0.008991 0.0419 0.002438 0.057583 Family history Chronic bronchitis emphysema (family history - sibling) T 300905 8228 292801 1.18 0.162378 0.053773 1.06 1.31 0.00253 0.059181 Musculoskeletal Synovitis and tenosynovitis (HES) T 378957 4728 374373 0.778 -0.25128 0.08372 0.66 0.917 0.002688 0.060509 Cardiovascular Heart attackmyocardial infarction (HES and self-reported) T 378957 12068 367033 0.857 -0.15396 0.051236 0.775 0.948 0.002657 0.060509 Digestive system Rectal or colon adenomapolyps (HES and self-reported) T 378957 28246 350855 0.905 -0.10003 0.033271 0.848 0.966 0.002643 0.060509 Musculoskeletal Osteoarthritis hip T 322846 10780 312194 0.852 -0.16038 0.05341 0.767 0.946 0.002676 0.060509 Operations and Procedures Endoscopic resection of outlet of male bladder T 378957 3901 375200 1.25 0.225806 0.075427 1.08 1.45 0.002756 0.061475 Other Relative age of first facial hair T 168786 NA NA NA 0.037284 0.012477 0.01283 0.061738 0.002805 0.062004 Respiratory FEV1 FVC ratio never smoked only strict T 84245 NA NA NA 0.05256 0.017632 0.018002 0.087118 0.002873 0.062927 Musculoskeletal Fracture shaft of femur (HES and self-reported) T 378957 596 378505 1.64 0.497214 0.16797 1.18 2.29 0.003075 0.066736 Medication Beta blocking agents T 378957 27196 351905 0.905 -0.10022 0.033897 0.846 0.967 0.003112 0.066936 Summary Disorders of sclera cornea iris and ciliary body (HES) T 378957 1464 377637 1.4 0.338541 0.114709 1.12 1.76 0.003164 0.067453 Operations and Procedures Total prosthetic replacement of knee joint using cement T 378957 7800 371301 0.829 -0.18745 0.063572 0.732 0.939 0.003192 0.067453 Operations and Procedures Colectomy hemicolectomy (self-reported) T 378957 1636 377465 1.38 0.322367 0.109432 1.11 1.71 0.003221 0.067473 Other Alcohol dependency (HES and self-reported) T 378957 5185 373916 0.789 -0.2368 0.081294 0.673 0.925 0.003581 0.074372 Eye Iridocyclitis (HES) T 378957 333 378768 1.85 0.616403 0.212239 1.22 2.81 0.003681 0.075787 Mental health Deliberate selfharmsuicide attempt (HES and self-reported) T 378957 2635 376466 0.71 -0.34251 0.11833 0.563 0.895 0.003797 0.077525 Operations and Procedures Attention to stent in organ NOC T 378957 390 378711 1.78 0.576722 0.199804 1.2 2.63 0.003896 0.078877 Mental health Mental and behavioural disorders due to use of alcohol (HES) T 378957 4907 374194 0.786 -0.24022 0.083657 0.668 0.927 0.004086 0.082021 Cardiovascular Acute myocardial infarction (HES) T 378957 7305 371796 0.827 -0.19002 0.066251 0.726 0.942 0.004129 0.082198 Biological assays Platelet count T 367720 NA NA NA 0.024136 0.008434 0.007605 0.040667 0.004214 0.083207 Operations and Procedures Prostate operation (self-reported) T 378957 859 378242 1.51 0.412188 0.144266 1.14 2 0.004275 0.083721 Operations and Procedures Other therapeutic on outlet of male bladder T 378957 850 378251 1.52 0.418146 0.146554 1.14 2.02 0.004328 0.083785 Respiratory FEV1 FVC ratio never smoked only T 109805 NA NA NA 0.044085 0.015459 0.013786 0.074384 0.004347 0.083785 Summary Nerve nerve root and plexus disorders (HES) T 378957 16103 362998 0.884 -0.12322 0.043349 0.812 0.962 0.004477 0.085598 Infectious disease Viral and other specified intestinal infections (HES) T 378957 770 378331 1.54 0.432166 0.152369 1.14 2.08 0.004564 0.086571 Summary Diseases of liver (HES) T 378957 4603 374498 1.22 0.198064 0.069983 1.06 1.4 0.004652 0.08756 Immuno-inflammation Sarcoidosis (HES) T 378957 489 378612 1.68 0.517463 0.183154 1.17 2.4 0.004724 0.088215 Genitourinary Prostate problem not cancer (HES and self-reported) T 378957 11913 367188 1.14 0.132442 0.046957 1.04 1.25 0.004795 0.088855 Cancer Myeloid leukaemia (cancer register) T 378957 321 378780 1.84 0.608261 0.216737 1.2 2.81 0.005009 0.091416 Respiratory Emphysemachronic bronchitis (HES and self-reported) T 378957 6338 372763 1.19 0.170082 0.060587 1.05 1.33 0.004997 0.091416 Operations and Procedures Approach to organ through other opening T 378957 1441 377660 0.623 -0.47372 0.169005 0.447 0.867 0.005063 0.091559 Operations and Procedures Radiology with contrast T 378957 12447 366654 1.13 0.123777 0.044189 1.04 1.23 0.005093 0.091559 Musculoskeletal Other inflammatory spondylopathies (HES) T 378957 1156 377945 0.58 -0.54464 0.195 0.396 0.85 0.005222 0.093177 Gynaecology and Obstetrics Breast cysts (HES and self-reported) T 378957 1673 377428 1.36 0.30548 0.109599 1.09 1.68 0.005316 0.094158 Cancer Prostate cancer (self-reported) T 378957 2722 376379 0.733 -0.31025 0.11225 0.588 0.914 0.005711 0.100429 Summary Spondylopathies (HES) T 378957 10706 368395 0.863 -0.14751 0.053523 0.777 0.958 0.005851 0.102142 Infectious disease Helicobacter pylori (HES) T 378957 748 378353 0.476 -0.7432 0.269943 0.28 0.807 0.005902 0.102284 Other Poisoning by nonopioid analgesics antipyretics and antirheumatics (HES) T 378957 1567 377534 0.643 -0.44102 0.160457 0.47 0.881 0.005986 0.103009 Digestive system Hepatic failure (HES) T 378957 298 378803 1.85 0.616268 0.22666 1.19 2.89 0.00655 0.111113 Neurosciences Headaches not migraine (self-reported) T 378957 3224 375877 1.25 0.22324 0.082105 1.06 1.47 0.006549 0.111113 Medication Beta blocking agents thiazides and other diuretics T 378957 15312 363789 0.886 -0.1209 0.044693 0.812 0.967 0.006829 0.114845 Operations and Procedures Therapeutic endoscopic operations on semilunar cartilage T 378957 12492 366609 0.875 -0.13377 0.049482 0.794 0.964 0.006865 0.114845 Musculoskeletal Coxarthrosis (HES) T 378957 10780 368321 0.867 -0.14229 0.053153 0.782 0.963 0.007429 0.123432 Summary Other dorsopathies (HES) T 378957 18099 361002 0.896 -0.10932 0.040871 0.827 0.971 0.007481 0.123434 Cardiovascular Pulmonary embolism dvt (HES and self-reported) T 378957 5241 373860 1.19 0.175707 0.065818 1.05 1.36 0.007595 0.124459 Medication Antacids T 378957 6182 372919 1.18 0.163399 0.061433 1.04 1.33 0.007819 0.125585 ENT Cholesteatoma of middle ear (HES) T 378957 393 378708 1.72 0.540087 0.20323 1.15 2.56 0.007872 0.125585 Neurosciences Knee pain T 378087 86052 292179 0.948 -0.05371 0.020201 0.911 0.986 0.007846 0.125585 Cardiovascular Venous thromboembolic disease (HES and self-reported) T 378957 3983 375118 1.22 0.198302 0.074548 1.05 1.41 0.007812 0.125585 Musculoskeletal Other spondylopathies (HES) T 378957 3685 375416 0.778 -0.25048 0.094448 0.647 0.937 0.008 0.126784 Symptoms Hepatomegaly and splenomegaly (HES) T 378957 590 378511 1.58 0.455916 0.172351 1.13 2.21 0.008163 0.128519 Medication All other therapeutic products T 378957 3557 375544 1.23 0.20757 0.078707 1.05 1.44 0.008358 0.130413 Respiratory FEV1 percent pred strict T 221584 NA NA NA 0.028744 0.010905 0.007371 0.050117 0.008391 0.130413 Cardiovascular Coronary artery bypass grafts cabg (self-reported) T 378957 2799 376302 0.747 -0.29217 0.111191 0.6 0.928 0.008598 0.132773 Haematology Diseases of spleen (HES) T 378957 463 378638 0.368 -0.99927 0.381005 0.174 0.777 0.008723 0.133208 Digestive system Stomach disorder (HES and self-reported) T 378957 7348 371753 1.16 0.148799 0.056746 1.04 1.3 0.008737 0.133208 Genitourinary Other disorders of bladder (HES) T 378957 8086 371015 1.15 0.141738 0.054301 1.04 1.28 0.009048 0.137093 Genitourinary Recurrent and persistent haematuria (HES) T 378957 660 378441 1.54 0.430854 0.165436 1.11 2.13 0.009205 0.137727 Digestive system Liverbiliarypancreas problem (HES and self-reported) T 378957 4283 374818 1.21 0.189746 0.072814 1.05 1.39 0.009163 0.137727 Other Toxic effect of alcohol (HES) T 378957 912 378189 0.556 -0.58738 0.226365 0.357 0.866 0.009463 0.139857 Operations and Procedures Primary decompression operations on lumbar spine T 378957 2461 376640 0.735 -0.30743 0.118402 0.583 0.927 0.009419 0.139857 Genitourinary Urinary tract infectionkidney infection (HES and self-reported) T 378957 12655 366446 1.12 0.114096 0.044252 1.03 1.22 0.009928 0.145834 Summary Certain disorders involving the immune mechanism (HES) T 378957 976 378125 1.43 0.35696 0.139142 1.09 1.88 0.010305 0.146888 Other Poisoning by psychotropic drugs (HES) T 378957 1062 378039 0.594 -0.52085 0.20269 0.399 0.884 0.010179 0.146888 Operations and Procedures Total prosthetic replacement of hip joint not using cement T 378957 4094 375007 0.797 -0.22684 0.088399 0.67 0.948 0.010285 0.146888 NA STEMI T 378957 3811 375290 0.787 -0.24015 0.093535 0.655 0.945 0.010245 0.146888 Family history Stroke (family history) T 378957 NA NA NA -0.02131 0.008301 -0.03758 -0.00504 0.010256 0.146888 Digestive system Other diseases of stomach and duodenum (HES) T 378957 6601 372500 1.16 0.152702 0.05963 1.04 1.31 0.010442 0.147516 Cancer Mal neo liver (cancer register) T 378957 217 378884 1.95 0.665385 0.260136 1.17 3.24 0.010533 0.147516 Cardiovascular Leg pain on walking T 125352 27294 98122 0.912 -0.09161 0.035811 0.851 0.979 0.010522 0.147516 Genitourinary Iga nephropathy (HES and self-reported) T 378957 666 378435 1.52 0.421179 0.165388 1.1 2.11 0.010878 0.151469 Summary Diabetes mellitus (HES) T 378957 17982 361119 0.901 -0.1043 0.04105 0.831 0.976 0.011059 0.153109 Operations and Procedures Replacement of hip joint T 378957 1139 377962 1.38 0.325503 0.128284 1.08 1.78 0.011169 0.153753 Metabolic Unspecified diabetes mellitus (HES) T 378957 2120 376981 0.721 -0.32702 0.129313 0.56 0.929 0.011443 0.156626 Operations and Procedures Other operations on sheath of tendon T 378957 2908 376193 0.764 -0.26938 0.107477 0.619 0.943 0.012197 0.166009 Eye Cataract (HES and self-reported) T 378957 20791 358310 1.09 0.089131 0.03581 1.02 1.17 0.012809 0.173353 Symptoms Ascites (HES) T 378957 1446 377655 1.34 0.293798 0.118234 1.06 1.69 0.01296 0.174413 Summary HESCH Diseases of the musculo and connec tissue (HES) T 378957 100763 278338 0.953 -0.04772 0.019242 0.918 0.99 0.013133 0.175476 Operations and Procedures Extracorporeal fragmentation of calculus of kidney T 378957 1421 377680 0.665 -0.40837 0.164748 0.481 0.918 0.013184 0.175476 Family history Diabetes (family history - sibling) T 300905 24485 276544 0.916 -0.0876 0.03539 0.855 0.982 0.013313 0.176218 Cardiovascular Mean carotid IMT intima medial thickness at 120 degrees T 1871 NA NA NA 0.309672 0.125236 0.064209 0.555135 0.013409 0.176514 Summary Disorders of lens (HES) T 378957 18482 360619 1.1 0.092862 0.037748 1.02 1.18 0.013892 0.181873 Cardiovascular Other peripheral vascular diseases (HES) T 378957 3304 375797 0.782 -0.24591 0.100658 0.642 0.953 0.014563 0.188614 Summary Mal neo lymphoid haematopoietic (cancer register) T 378957 3145 375956 1.23 0.204025 0.083455 1.04 1.44 0.014496 0.188614 Summary Mood affective disorders (HES) T 378957 11549 367552 0.883 -0.12471 0.051154 0.799 0.976 0.014768 0.19025 Summary Other diseases of urinary system (HES) T 378957 26755 352346 1.08 0.077108 0.031658 1.02 1.15 0.014867 0.190498 Musculoskeletal Joint pain (HES and self-reported) T 378957 8344 370757 0.863 -0.14717 0.060491 0.767 0.972 0.014978 0.190915 Cardiovascular Atherosclerosis (HES) T 378957 1127 377974 0.633 -0.45744 0.188545 0.437 0.916 0.015259 0.192458 Family history Parkinson s disease (family history) T 378957 NA NA NA -0.02011 0.008287 -0.03635 -0.00387 0.015226 0.192458 Haematology Iron deficiency anaemia (HES) T 378957 6915 372186 0.851 -0.16149 0.066823 0.746 0.97 0.01566 0.196488 Eye Intra ocular pressure corneal compensated left T 81021 NA NA NA -0.0429 0.017772 -0.07774 -0.00807 0.015777 0.196928 Neurosciences Myasthenia gravis (HES and self-reported) T 378957 206 378895 1.91 0.647126 0.268443 1.13 3.23 0.015924 0.197732 Summary Other forms of heart disease (HES) T 378957 26042 353059 0.921 -0.0827 0.034399 0.861 0.985 0.016213 0.198234 Digestive system Other diseases of liver (HES) T 378957 3122 375979 1.22 0.202172 0.084445 1.04 1.44 0.01666 0.198234 Immuno-inflammation Nail disorders (HES) T 378957 1050 378051 1.39 0.329649 0.137679 1.06 1.82 0.016651 0.198234 Symptoms Abnormal findings on diagnostic imaging of CNS (HES) T 378957 319 378782 1.72 0.542688 0.226057 1.1 2.68 0.016365 0.198234 Medication Antimigraine preparations T 378957 5449 373652 1.17 0.155235 0.065057 1.03 1.33 0.017026 0.198234 Operations and Procedures Spinal fusion (self-reported) T 378957 517 378584 0.465 -0.76496 0.319176 0.249 0.87 0.016545 0.198234 Cancer Mal neo prostate (cancer register) T 378957 6546 372555 0.848 -0.16475 0.069108 0.741 0.971 0.017129 0.198234 Operations and Procedures High cost musculoskeletal drugs T 378957 570 378531 1.53 0.424618 0.177153 1.08 2.16 0.016535 0.198234 Medication Vitamin D T 376892 14603 362433 1.1 0.099116 0.041518 1.02 1.2 0.016973 0.198234 Genitourinary Bladder problem not cancer (HES and self-reported) T 378957 10748 368353 1.12 0.114371 0.047884 1.02 1.23 0.016917 0.198234 Neurosciences Bells palsyfacial nerve palsy (HES and self-reported) T 378957 922 378179 1.41 0.343988 0.144385 1.06 1.87 0.017198 0.198234 Immuno-inflammation Sarcoidosis (HES and self-reported) T 378957 930 378171 1.41 0.342189 0.143042 1.06 1.86 0.016746 0.198234 Musculoskeletal Soft tissue inflammation (HES and self-reported) T 378957 9317 369784 0.873 -0.13575 0.056962 0.781 0.976 0.017169 0.198234 Family history Alzheimer s disease dementia (family history) T 378957 NA NA NA -0.01979 0.008292 -0.03604 -0.00354 0.017008 0.198234 Anthropometry Gynoid tissue fat percentage T 4100 NA NA NA 0.20597 0.086266 0.036888 0.375052 0.016959 0.198234 Anthropometry Legs tissue fat percentage T 4100 NA NA NA 0.204904 0.086174 0.036004 0.373804 0.017416 0.199788 Haematology Iron deficiency anaemia (HES and self-reported) T 378957 8597 370504 0.868 -0.14108 0.059515 0.773 0.976 0.017766 0.20284 Digestive system Cholecystitis (HES and self-reported) T 378957 2791 376310 1.23 0.209819 0.088707 1.04 1.47 0.018015 0.204706 Gynaecology and Obstetrics Bilateral oophorectomy both ovaries removed T 201515 16364 185221 0.902 -0.10285 0.043532 0.828 0.983 0.018144 0.205208 Digestive system Gastro oesophageal reflux disease (HES) T 378957 20891 358210 0.915 -0.08923 0.037892 0.849 0.985 0.01853 0.207617 Eye Intra ocular pressure Goldmann correlated left T 81021 NA NA NA -0.04188 0.017777 -0.07672 -0.00704 0.018482 0.207617 Eye Other eye problems T 377814 54312 323646 1.06 0.055017 0.02339 1.01 1.11 0.018666 0.208174 Operations and Procedures Small bowel resection (self-reported) T 378957 657 378444 1.48 0.392804 0.167423 1.07 2.06 0.018967 0.20894 Operations and Procedures Removal of other inorganic substance from skin T 378957 431 378670 0.409 -0.89504 0.381217 0.194 0.863 0.018882 0.20894 Cardiovascular Peripheral vascular disease (HES and self-reported) T 378957 1859 377242 0.723 -0.32479 0.138463 0.551 0.948 0.018995 0.20894 Cancer Ovarian cancer (self-reported) T 378957 645 378456 0.531 -0.63302 0.270532 0.312 0.902 0.019289 0.211212 Other Birth weight T 215451 NA NA NA -0.02573 0.011009 -0.04731 -0.00415 0.019431 0.211811 Operations and Procedures Spinal laminectomy (self-reported) T 378957 3219 375882 0.79 -0.23587 0.101027 0.648 0.963 0.019556 0.212056 Operations and Procedures Other operations on ligament T 378957 254 378847 0.191 -1.65652 0.709931 0.0475 0.767 0.01963 0.212056 Operations and Procedures Hip replacement revision (self-reported) T 378957 6037 373064 0.847 -0.16605 0.071231 0.737 0.974 0.019749 0.212392 Genitourinary Endometriosis (HES) T 378957 3557 375544 0.801 -0.22183 0.09541 0.664 0.966 0.020072 0.214905 Other Relative age voice broke T 161554 NA NA NA 0.029584 0.012744 0.004607 0.054562 0.02026 0.215954 Respiratory FEV1 percent pred T 285833 NA NA NA 0.022225 0.009591 0.003427 0.041022 0.020485 0.217395 Cardiovascular Other aneurysm (HES) T 378957 436 378665 1.59 0.460625 0.19908 1.07 2.34 0.020681 0.21781 Biological assays Red blood cell erythrocyte distribution width T 367720 NA NA NA 0.019522 0.008439 0.002982 0.036062 0.020705 0.21781 Operations and Procedures Other therapeutic operations on bile duct T 378957 284 378817 1.73 0.548452 0.237808 1.09 2.76 0.021095 0.219992 Haematology Hereditarygenetic haematological disorder (HES and self-reported) T 378957 463 378638 1.57 0.450648 0.195274 1.07 2.3 0.021012 0.219992 Medication Beta blocking agents other combinations T 378957 42301 336800 0.939 -0.0634 0.027583 0.889 0.991 0.021524 0.222119 Musculoskeletal Spondylosis (HES) T 378957 6891 372210 0.858 -0.15309 0.066639 0.753 0.978 0.021599 0.222119 Operations and Procedures Total excision of breast T 378957 4061 375040 0.816 -0.20366 0.08859 0.686 0.97 0.021512 0.222119 Musculoskeletal Cervical spondylosis (HES and self-reported) T 378957 4865 374236 0.831 -0.18517 0.080702 0.709 0.973 0.02176 0.222119 ENT Vertigo (HES and self-reported) T 378957 697 378404 1.45 0.374627 0.163201 1.06 2 0.021705 0.222119 Mental health Depressive episode (HES) T 378957 10665 368436 0.886 -0.12115 0.053093 0.798 0.983 0.022499 0.224897 Operations and Procedures Other operations on female perineum T 378957 887 378214 1.4 0.336563 0.147478 1.05 1.87 0.022482 0.224897 Operations and Procedures Suture of organ NOC T 378957 640 378461 1.47 0.387486 0.169668 1.06 2.05 0.022383 0.224897 Cardiovascular Aortic stenosis (HES and self-reported) T 378957 1728 377373 0.722 -0.326 0.142641 0.546 0.955 0.022287 0.224897 Family history Diabetes (family history) T 378957 NA NA NA -0.01898 0.008298 -0.03524 -0.00271 0.022191 0.224897 Summary Disorders of psychological development (HES) T 378957 287 378814 1.72 0.540326 0.237718 1.08 2.74 0.023028 0.225361 Eye Other disorders of cornea (HES) T 378957 582 378519 1.5 0.403179 0.177055 1.06 2.12 0.022778 0.225361 Digestive system Other diseases of anus and rectum (HES) T 378957 21218 357883 0.918 -0.08547 0.037626 0.853 0.988 0.023107 0.225361 Cardiovascular Cardiac ablation (self-reported) T 378957 269 378832 0.266 -1.32307 0.580736 0.0853 0.831 0.022711 0.225361 Digestive system Bile duct obstructionascending cholangitis (HES and self-reported) T 378957 936 378165 1.39 0.327967 0.144347 1.05 1.84 0.023082 0.225361 Musculoskeletal Spinal stenosis (HES and self-reported) T 378957 3421 375680 0.803 -0.21975 0.096561 0.664 0.97 0.022864 0.225361 Musculoskeletal Osteoporosis without pathological fracture (HES) T 378957 5396 373705 1.16 0.149848 0.066234 1.02 1.32 0.023672 0.227967 Neurosciences Knee pain for 3 months vs no pain T 354567 62522 292179 0.949 -0.05188 0.022958 0.908 0.993 0.023847 0.227967 Operations and Procedures Surgical arrest of bleeding from internal nose T 378957 782 378319 1.42 0.352475 0.155576 1.05 1.93 0.023475 0.227967 Cardiovascular Deep venous thrombosis dvt (HES and self-reported) T 378957 8917 370184 1.12 0.117595 0.052031 1.02 1.25 0.023816 0.227967 Musculoskeletal Disc degeneration (HES and self-reported) T 378957 2914 376187 0.787 -0.23923 0.105768 0.64 0.969 0.023707 0.227967 Digestive system Fibrosis and cirrhosis of liver (HES) T 378957 756 378345 1.43 0.358405 0.159121 1.05 1.95 0.024296 0.231344 Operations and Procedures Transurethral resection bladder tumour turbt (self-reported) T 378957 458 378643 1.55 0.439353 0.195514 1.06 2.28 0.024629 0.233144 Musculoskeletal Back pain (HES and self-reported) T 378957 14806 364295 0.904 -0.10073 0.04484 0.828 0.987 0.024679 0.233144 Cancer Mal neo brain (cancer register) T 378957 407 378694 1.59 0.463518 0.206728 1.06 2.38 0.024951 0.234792 Family history Heart disease (family history - sibling) T 300905 29868 271161 0.93 -0.07256 0.03257 0.872 0.991 0.025883 0.241679 Operations and Procedures Transluminal operations on varicose vein of leg T 378957 1198 377903 1.34 0.291341 0.130754 1.04 1.73 0.02587 0.241679 Operations and Procedures Carpal tunnel surgery (self-reported) T 378957 3953 375148 0.821 -0.19666 0.088723 0.69 0.977 0.026653 0.24229 Other Hair balding pattern T 173207 117813 55466 0.943 -0.0587 0.026445 0.895 0.993 0.026443 0.24229 Other Pattern 1 f T 173207 55466 117813 1.06 0.058699 0.026445 1.01 1.12 0.026443 0.24229 Other Pattern 2 f T 173207 39959 133320 0.935 -0.06699 0.030127 0.882 0.992 0.026173 0.24229 Operations and Procedures Punch biopsy of skin T 378957 3326 375775 1.2 0.182491 0.082309 1.02 1.41 0.026612 0.24229 Anthropometry Hip circumference T 378245 NA NA NA 0.018466 0.008323 0.002154 0.034778 0.026501 0.24229 Eye Intra ocular pressure Goldmann correlated right T 81141 NA NA NA -0.0394 0.017737 -0.07416 -0.00464 0.02632 0.24229 Eye Cataract T 124323 11723 112653 1.11 0.106854 0.048289 1.01 1.22 0.026911 0.243718 Operations and Procedures Introduction of abortifacient into uterine cavity T 378957 623 378478 0.55 -0.59784 0.27171 0.323 0.937 0.027787 0.250711 Summary Other disorders of kidney and ureter (HES) T 378957 2376 376725 1.23 0.210246 0.095713 1.02 1.49 0.028047 0.251173 Operations and Procedures Other local flap of skin T 378957 1956 377145 1.26 0.229887 0.104639 1.03 1.54 0.028024 0.251173 Musculoskeletal Spine arthritisspondylitis (HES and self-reported) T 378957 10404 368697 0.889 -0.118 0.053765 0.8 0.987 0.02818 0.251316 Musculoskeletal Falls in the last year T 378025 NA NA NA -0.01827 0.008331 -0.0346 -0.00195 0.028272 0.251316 Cardiovascular Mitral valve prolapse (HES and self-reported) T 378957 545 378556 1.49 0.400175 0.182563 1.04 2.13 0.028381 0.251361 Operations and Procedures Block dissection of lymph nodes T 378957 5157 373944 0.844 -0.16956 0.077553 0.725 0.983 0.028788 0.254026 Summary Other diseases of intestines (HES) T 378957 59649 319452 0.95 -0.05102 0.023423 0.908 0.995 0.029384 0.255654 Summary Disorders of bone density and structure (HES) T 378957 8188 370913 1.13 0.118836 0.05463 1.01 1.25 0.029609 0.255654 Digestive system Other diseases of pancreas (HES) T 378957 1002 378099 1.36 0.308307 0.141497 1.03 1.8 0.02934 0.255654 Genitourinary Other disorders of kidney and ureter (HES) T 378957 2178 376923 1.24 0.216907 0.099643 1.02 1.51 0.029492 0.255654 Operations and Procedures Approach to organ under image control T 378957 45067 334034 0.944 -0.05755 0.026446 0.896 0.994 0.029543 0.255654 Musculoskeletal Sjogrens syndromesicca syndrome (HES and self-reported) T 378957 614 378487 1.46 0.379649 0.174507 1.04 2.06 0.029589 0.255654 Musculoskeletal Raynauds phenomenondisease (HES and self-reported) T 378957 1315 377786 0.696 -0.3631 0.167047 0.501 0.965 0.029731 0.255793 Summary Mal neo of male genital organs (cancer register) T 378957 7046 372055 0.867 -0.14328 0.066141 0.761 0.986 0.030286 0.259644 Summary Metabolic disorders (HES) T 378957 39911 339190 0.941 -0.0609 0.028231 0.89 0.994 0.030983 0.260061 Metabolic Non insulin dependent diabetes mellitus (HES) T 378957 16601 362500 0.912 -0.0917 0.04244 0.84 0.992 0.030726 0.260061 Genitourinary Other disorders of urinary system (HES) T 378957 17515 361586 1.09 0.082911 0.038428 1.01 1.17 0.030962 0.260061 Operations and Procedures Other excision of breast T 378957 9523 369578 0.885 -0.12198 0.056461 0.792 0.989 0.030739 0.260061 Family history Prostate cancer (family history) T 174646 NA NA NA 0.026453 0.012256 0.002431 0.050474 0.030902 0.260061 Biological assays Mean platelet thrombocyte volume T 367716 NA NA NA -0.01821 0.00844 -0.03476 -0.00167 0.030918 0.260061 Symptoms Syncope and collapse (HES) T 378957 8267 370834 0.878 -0.1304 0.060488 0.78 0.988 0.031102 0.260151 Biological assays Monocyte count T 367067 NA NA NA 0.01818 0.008444 0.001631 0.034729 0.031309 0.260984 Operations and Procedures Endoscopic extirpation of lesion of colon T 378957 14469 364632 0.907 -0.09769 0.045583 0.829 0.992 0.032108 0.266718 Metabolic Type 2 diabetes (HES and self-reported) T 378957 17351 361750 0.915 -0.08892 0.04152 0.843 0.992 0.032223 0.26675 Other DIED T 378957 10919 368182 1.11 0.102585 0.047948 1.01 1.22 0.032395 0.267262 Cardiovascular Triple heart bypass (self-reported) T 378957 526 378575 0.536 -0.62438 0.292561 0.302 0.95 0.032827 0.268929 Operations and Procedures Unilateral excision of adnexa of uterus T 378957 1862 377239 0.748 -0.29084 0.136358 0.572 0.977 0.032932 0.268929 Cardiovascular Heart arrhythmia (HES and self-reported) T 378957 21190 357911 0.923 -0.08051 0.037736 0.857 0.993 0.032883 0.268929 Summary Abnormal findings on diagnostic imaging (HES) T 378957 8914 370187 1.12 0.111812 0.052469 1.01 1.24 0.033088 0.269283 Operations and Procedures Total excision of spleen T 378957 281 378820 0.344 -1.06733 0.503383 0.128 0.922 0.033979 0.275604 Gynaecology and Obstetrics Bilateral oophorectomy (self-reported) T 378957 15863 363238 0.911 -0.09274 0.04393 0.836 0.993 0.034768 0.278705 Operations and Procedures Therapeutic transluminal operations on vein T 378957 314 378787 1.63 0.488236 0.231382 1.04 2.56 0.034851 0.278705 Operations and Procedures Facilitating operations NOC T 378957 2533 376568 0.788 -0.23857 0.112906 0.631 0.983 0.034603 0.278705 Medication Calcium T 377706 25583 352267 1.07 0.068979 0.032737 1 1.14 0.035111 0.278705 Digestive system Infectiveviral hepatitis (HES and self-reported) T 378957 1240 377861 0.692 -0.36754 0.174109 0.492 0.974 0.034777 0.278705 Musculoskeletal Polymyalgia rheumatica (HES and self-reported) T 378957 1540 377561 1.28 0.244822 0.116152 1.02 1.6 0.03505 0.278705 Respiratory CopdExacerbation NI HES SPIROMETRY T 25076 2309 22801 1.25 0.219775 0.104337 1.02 1.53 0.035171 0.278705 Medication Antispasmodics in combination with analgesics T 378957 607 378494 1.45 0.371449 0.176832 1.03 2.05 0.035679 0.280781 Medication Tetracyclines T 378957 2224 376877 1.23 0.209763 0.099933 1.01 1.5 0.035814 0.280781 Operations and Procedures Cruciate ligament surgery (self-reported) T 378957 1888 377213 0.752 -0.28546 0.13606 0.576 0.981 0.035899 0.280781 Operations and Procedures Other open operations on peritoneum T 378957 2184 376917 1.23 0.209911 0.100011 1.01 1.5 0.035828 0.280781 Digestive system Other disorders of peritoneum (HES) T 378957 2824 376277 1.2 0.186437 0.088968 1.01 1.43 0.036123 0.281615 Operations and Procedures Prosthesis of lens T 378957 17908 361193 1.08 0.080538 0.038485 1.01 1.17 0.036373 0.282652 Summary Diseases of myoneural junction and muscle (HES) T 378957 482 378619 1.5 0.407278 0.194996 1.03 2.2 0.03674 0.283673 Summary Mal neo of central nervous system (cancer register) T 378957 562 378539 1.46 0.380876 0.182333 1.02 2.09 0.036716 0.283673 Medication Multivitamins combinations T 378957 19000 360101 0.921 -0.08274 0.039692 0.852 0.995 0.037103 0.284651 Medication High ceiling diuretics T 378957 3930 375171 0.83 -0.18668 0.089505 0.696 0.989 0.03701 0.284651 Neurosciences Hip pain for 3 months vs no pain T 362543 32691 329991 0.938 -0.06351 0.030546 0.884 0.996 0.037616 0.287671 Operations and Procedures Transluminal operations on aorta T 378957 858 378243 0.638 -0.44898 0.216353 0.418 0.975 0.037965 0.28942 Operations and Procedures Other destruction of lesion of skin of other site T 378957 282 378819 1.66 0.505731 0.243893 1.03 2.67 0.038119 0.289623 Other Overall acceleration average T 81434 NA NA NA -0.0371 0.017905 -0.0722 -0.00201 0.038232 0.289623 Gynaecology and Obstetrics Termination of pregnancy top (self-reported) T 378957 945 378156 0.662 -0.41211 0.199295 0.448 0.979 0.038655 0.290997 Biological assays Mean sphered cell volume T 361631 NA NA NA 0.017602 0.008508 0.000927 0.034278 0.038551 0.290997 Operations and Procedures Other excision of appendix T 378957 1270 377831 1.3 0.263393 0.127678 1.01 1.67 0.039117 0.29191 Operations and Procedures Transluminal heart assist operations T 378957 275 378826 0.354 -1.03936 0.503881 0.132 0.95 0.039139 0.29191 Operations and Procedures Urethral catheterisation of bladder T 378957 10309 368792 1.11 0.101043 0.048978 1.01 1.22 0.039108 0.29191 Mental health Seen doctor GP for nerves anxiety tension or depression T 376297 129804 246635 0.964 -0.03689 0.017904 0.931 0.998 0.039344 0.292528 Summary Diseases of peritoneum (HES) T 378957 3415 375686 1.18 0.167937 0.081699 1.01 1.39 0.039825 0.293388 Operations and Procedures Endoscopic bilateral occlusion of fallopian tubes T 378957 2687 376414 0.794 -0.23019 0.111969 0.638 0.989 0.039797 0.293388 Infectious disease Septicaemia sepsis (HES and self-reported) T 378957 3840 375261 1.17 0.159065 0.077335 1.01 1.36 0.039704 0.293388 Eye Senile cataract (HES) T 378957 7529 371572 1.12 0.116491 0.056776 1.01 1.26 0.040192 0.294293 Genitourinary Other inflammation of vagina and vulva (HES) T 378957 690 378411 0.604 -0.50478 0.245896 0.373 0.977 0.040089 0.294293 Operations and Procedures Cystectomy (self-reported) T 378957 1986 377115 1.24 0.213906 0.104495 1.01 1.52 0.040654 0.296776 Summary Other disorders of the genitourinary system (HES) T 378957 1063 378038 1.32 0.280904 0.137702 1.01 1.73 0.041356 0.300079 Genitourinary Postprocedural disorders of genitourinary system (HES) T 378957 1063 378038 1.32 0.280904 0.137702 1.01 1.73 0.041356 0.300079 Operations and Procedures Levels of spine T 378957 6828 372273 0.874 -0.13465 0.066165 0.768 0.995 0.041849 0.302742 Summary Symptoms and signs involving the urinary system (HES) T 378957 26525 352576 1.07 0.06513 0.032041 1 1.14 0.042079 0.303499 Operations and Procedures High cost immunosuppressant drugs T 378957 602 378499 1.43 0.359066 0.176863 1.01 2.03 0.042337 0.304445 Cardiovascular Aortic aneurysm repair or stent (self-reported) T 378957 277 378824 1.64 0.494059 0.244272 1.02 2.65 0.043117 0.309133 Respiratory Vasomotor and allergic rhinitis (HES) T 378957 952 378149 1.34 0.293908 0.145605 1.01 1.78 0.043537 0.310313 Operations and Procedures Skin graft (self-reported) T 378957 649 378452 0.6 -0.51085 0.253326 0.365 0.986 0.043738 0.310313 Operations and Procedures Extracapsular extraction of lens T 378957 17912 361189 1.08 0.077685 0.038534 1 1.17 0.043797 0.310313 Operations and Procedures Partial excision of liver T 378957 334 378767 0.435 -0.83181 0.412102 0.194 0.976 0.043543 0.310313 Mental health Dementia in Alzheimer s disease (HES) T 378957 223 378878 1.71 0.539279 0.267855 1.01 2.9 0.044081 0.31141 Musculoskeletal Gout (HES) T 378957 2920 376181 0.81 -0.21073 0.105059 0.659 0.995 0.04487 0.314024 Musculoskeletal Other arthrosis (HES) T 378957 14991 364110 0.915 -0.08909 0.044409 0.839 0.998 0.04485 0.314024 Gynaecology and Obstetrics Ectopic pregnancy surgery (self-reported) T 378957 2218 376883 0.784 -0.24293 0.121215 0.618 0.995 0.04506 0.314024 Operations and Procedures Body region T 378957 6404 372697 1.13 0.122315 0.060908 1 1.27 0.044622 0.314024 Biological assays Platelet crit T 367717 NA NA NA 0.016898 0.008433 0.000369 0.033428 0.045103 0.314024 Operations and Procedures Diagnostic puncture of bone T 378957 3796 375305 1.17 0.155749 0.077781 1 1.36 0.04524 0.31407 Summary Diseases of oesophagus stomach and duodenum (HES) T 378957 55390 323711 0.953 -0.04828 0.024141 0.909 0.999 0.045509 0.314127 Symptoms Other abnormal immunological findings in serum (HES) T 378957 247 378854 1.68 0.518015 0.258987 1.01 2.79 0.045484 0.314127 Summary Number of self reported non cancer illnesses T 378896 NA NA NA 0.016614 0.008313 0.000321 0.032906 0.045649 0.314195 Summary HESCH Mental and behavioural disorders (HES) T 378957 29106 349995 0.938 -0.06429 0.032198 0.88 0.999 0.045873 0.314835 Operations and Procedures Diagnostic endoscopic examination of ileum T 378957 590 378511 0.583 -0.53956 0.270639 0.343 0.991 0.046189 0.315816 Operations and Procedures Other operations on cervix uteri T 378957 247 378854 1.68 0.516008 0.258929 1.01 2.78 0.046278 0.315816 Operations and Procedures Endoscopic ultrasound examination of bile duct T 378957 228 378873 1.7 0.532476 0.267443 1.01 2.88 0.046482 0.31592 Other Townsend deprivation index at recruitment T 378505 NA NA NA -0.01646 0.008272 -0.03268 -0.00025 0.046555 0.31592 NA NSTEMI T 378957 4419 374682 0.847 -0.16653 0.083841 0.718 0.998 0.047005 0.316995 Cardiovascular Leg claudication intermittent claudication (HES and self-reported) T 378957 2468 376633 0.795 -0.22976 0.115729 0.633 0.997 0.047109 0.316995 Haematology Anaemia (HES and self-reported) T 378957 17268 361833 0.921 -0.08214 0.04135 0.849 0.999 0.046992 0.316995 Medication Corticosteroids T 378957 4111 374990 1.16 0.14828 0.075021 1 1.34 0.048096 0.319816 Operations and Procedures Reconstruction of femoral artery T 378957 231 378870 0.316 -1.15115 0.581343 0.101 0.988 0.047686 0.319816 Operations and Procedures Plastic operations on penis T 378957 394 378707 1.53 0.425779 0.215355 1 2.33 0.04803 0.319816 Digestive system Anal problem (HES and self-reported) T 378957 23889 355212 0.933 -0.06981 0.035355 0.87 0.999 0.048324 0.319816 Digestive system Haemochromatosis (HES and self-reported) T 378957 635 378466 1.42 0.349445 0.176659 1 2.01 0.04792 0.319816 Musculoskeletal Fracture tibia (HES and self-reported) T 378957 1942 377159 1.23 0.209621 0.106119 1 1.52 0.04823 0.319816 Digestive system Other diseases of biliary tract (HES) T 378957 1752 377349 1.24 0.218904 0.110992 1 1.55 0.048582 0.32023 Medication Dopaminergic agents T 378957 1188 377913 0.71 -0.34296 0.174283 0.504 0.999 0.04909 0.32023 Neurosciences Back pain for 3 months vs no pain T 341405 65312 276219 0.957 -0.04442 0.022597 0.915 1 0.049327 0.32023 Cancer Mal neo pancreas (cancer register) T 378957 463 378638 1.48 0.389615 0.19868 1 2.18 0.049877 0.32023 Operations and Procedures Connection between lacrimal apparatus and nose T 378957 711 378390 0.626 -0.46857 0.238969 0.392 1 0.049901 0.32023 Operations and Procedures Transluminal operations on femoral artery T 378957 1076 378025 0.695 -0.36381 0.185607 0.483 1 0.049982 0.32023 Operations and Procedures Diagnostic imaging procedures T 378957 15463 363638 1.08 0.079648 0.040625 1 1.17 0.049928 0.32023 Infectious disease Whooping cough pertussis (HES and self-reported) T 378957 415 378686 1.5 0.405456 0.206649 1 2.25 0.049757 0.32023 Musculoskeletal Fracture radius (HES and self-reported) T 378957 5082 374019 0.859 -0.15199 0.077528 0.738 1 0.049936 0.32023 Musculoskeletal Fracture upper limb shoulder (HES and self-reported) T 378957 10515 368586 0.901 -0.10471 0.053165 0.811 0.999 0.048899 0.32023 Biological assays Monocyte percentage T 367073 NA NA NA 0.016626 0.008445 7.30E-05 0.033179 0.048994 0.32023 Biological assays Neutrophill percentage T 367073 NA NA NA -0.01664 0.008445 -0.03319 -8.83E-05 0.048786 0.32023 Genitourinary Other female pelvic inflammatory diseases (HES) T 378957 2493 376608 1.2 0.185294 0.09486 0.999 1.45 0.050778 0.324458 Metabolic Diabetes (HES and self-reported) T 378957 15907 363194 0.919 -0.08422 0.043139 0.845 1 0.050911 0.324458 Eye Other disorders of conjunctiva (HES) T 378957 672 378429 0.621 -0.47709 0.245857 0.383 1 0.052317 0.327857 Musculoskeletal Seropositive rheumatoid arthritis (HES) T 378957 529 378572 1.44 0.365721 0.188327 0.997 2.09 0.052144 0.327857 Cardiovascular Mitral valve repair replacement (self-reported) T 378957 354 378747 0.476 -0.7422 0.38193 0.225 1.01 0.05198 0.327857 Operations and Procedures Operations on spinal nerve root T 378957 2302 376799 0.794 -0.23057 0.118505 0.629 1 0.051698 0.327857 Operations and Procedures Correction of deformity of eyelid T 378957 816 378285 1.35 0.30179 0.155486 0.997 1.83 0.052266 0.327857 Operations and Procedures Transluminal balloon angioplasty of coronary artery T 378957 2913 376188 0.816 -0.20285 0.104571 0.665 1 0.052397 0.327857 Gynaecology and Obstetrics Ovarian problem (HES and self-reported) T 378957 4956 374145 0.859 -0.15222 0.078391 0.736 1 0.052155 0.327857 Medication Urologicals T 378957 6031 373070 0.872 -0.13645 0.070563 0.76 1 0.053145 0.329 Cardiovascular Atrioventricular and left bundle branch block (HES) T 378957 3286 375815 0.829 -0.18776 0.0972 0.685 1 0.053399 0.329 Symptoms Retention of urine (HES) T 378957 6149 372952 1.13 0.120846 0.062553 0.998 1.28 0.053374 0.329 Operations and Procedures Other therapeutic transluminal operations on vein T 378957 1371 377730 1.27 0.238028 0.12307 0.997 1.61 0.053102 0.329 Operations and Procedures Diagnostic endoscopic examination of urethra T 378957 369 378732 1.53 0.426426 0.220249 0.995 2.36 0.052854 0.329 Musculoskeletal Sciatica (HES and self-reported) T 378957 5455 373646 0.866 -0.14422 0.074535 0.748 1 0.053005 0.329 Operations and Procedures Preprosthetic oral surgery T 378957 274 378827 1.62 0.483331 0.250713 0.992 2.65 0.053877 0.331093 Cardiovascular Essential hypertension (HES and self-reported) T 378957 71076 308025 0.958 -0.04289 0.022298 0.917 1 0.054442 0.333715 Haematology Neutropenialymphopenia (HES and self-reported) T 378957 2972 376129 1.18 0.167753 0.087353 0.997 1.4 0.054806 0.335094 Musculoskeletal Osteopenia (HES and self-reported) T 378957 990 378111 1.32 0.27393 0.143064 0.994 1.74 0.055526 0.338636 Medication Antifungals for systemic use T 378957 843 378258 1.35 0.296396 0.155163 0.992 1.82 0.056104 0.340221 Cardiovascular Atrial fibrillation and flutter (HES) T 378957 13484 365617 0.914 -0.0897 0.046951 0.834 1 0.056076 0.340221 Digestive system Ventral hernia (HES) T 378957 3093 376008 1.18 0.163764 0.085816 0.996 1.39 0.05635 0.340221 Other Poisoning by narcotics and psychodysleptics (HES) T 378957 598 378503 0.597 -0.51641 0.270597 0.351 1.01 0.056339 0.340221 Summary Disorders of conjunctiva (HES) T 378957 908 378193 0.679 -0.38653 0.203048 0.456 1.01 0.05696 0.34304 Eye Other cataract (HES) T 378957 13094 366007 1.09 0.084144 0.044316 0.997 1.19 0.057599 0.344321 Cancer Breast cancer (self-reported) T 378957 8389 370712 0.893 -0.11354 0.0598 0.794 1 0.057601 0.344321 Metabolic Type 1 diabetes (HES and self-reported) T 378957 2663 376438 0.812 -0.20789 0.109392 0.656 1.01 0.057377 0.344321 Digestive system Cholecystitis (HES) T 378957 2442 376659 1.2 0.181884 0.095971 0.994 1.45 0.058065 0.346233 Summary Nutritional anaemias (HES) T 378957 7757 371344 0.889 -0.11731 0.061934 0.788 1 0.058218 0.346291 Metabolic Hypofunction and other disorders of pituitary gland (HES) T 378957 359 378742 0.485 -0.72277 0.381855 0.23 1.03 0.058386 0.346434 Symptoms Pain in throat and chest (HES) T 378957 28963 350138 0.941 -0.06094 0.032235 0.883 1 0.058698 0.347426 Metabolic Disorders of mineral metabolism (HES) T 378957 1975 377126 1.22 0.199657 0.106135 0.992 1.5 0.05995 0.353967 Musculoskeletal Dorsalgia (HES) T 378957 13010 366091 0.915 -0.08936 0.047541 0.833 1 0.060145 0.354251 Haematology Other anaemias (HES) T 378957 10478 368623 0.905 -0.09936 0.053021 0.816 1 0.06093 0.357242 Operations and Procedures Excision of salivary gland T 378957 935 378166 0.689 -0.37293 0.19913 0.466 1.02 0.061097 0.357242 ENT Speech reception threshold SRT estimate left T 114644 NA NA NA 0.02801 0.014949 -0.00129 0.057309 0.060968 0.357242 Gynaecology and Obstetrics Age started hormone replacement therapy HRT T 71364 NA NA NA 0.036159 0.019336 -0.00174 0.074057 0.061481 0.358612 Medication Ace inhibitors combinations T 378957 54539 324562 0.955 -0.04621 0.024734 0.91 1 0.061704 0.359048 Operations and Procedures Therapeutic endoscopic operations on peritoneum T 378957 1599 377502 1.24 0.217605 0.116577 0.989 1.56 0.061955 0.359638 Eye Disorders of orbit (HES) T 378957 250 378851 0.392 -0.9368 0.50387 0.146 1.05 0.062997 0.364809 Medication Diuretics and potassium sparing agents in combination T 378957 27954 351147 0.941 -0.06117 0.03296 0.882 1 0.063477 0.366703 Summary Mental disorders due to psychoactive sub (HES) T 378957 14024 365077 0.918 -0.0858 0.046307 0.838 1 0.063896 0.368241 Summary HESCH Diseases of the genitourinary system (HES) T 378957 91318 287783 1.04 0.036098 0.019539 0.998 1.08 0.064682 0.37179 Musculoskeletal Other necrotizing vasculopathies (HES) T 378957 542 378559 1.42 0.347538 0.18822 0.979 2.05 0.064828 0.37179 Operations and Procedures Cardioverter defibrillator introduced through the vein T 378957 599 378502 0.617 -0.48291 0.26183 0.369 1.03 0.065129 0.37179 Gynaecology and Obstetrics Breast fibroadenoma (HES and self-reported) T 378957 1450 377651 0.753 -0.28337 0.153568 0.557 1.02 0.065 0.37179 Musculoskeletal Disorders of patella (HES) T 378957 841 378260 1.33 0.2849 0.155182 0.981 1.8 0.066371 0.371878 Musculoskeletal Internal derangement of knee (HES) T 378957 13926 365175 0.919 -0.0845 0.045918 0.84 1.01 0.06572 0.371878 Other Poisoning antiepileptic hypnotic antiparkinsonism drugs (HES) T 378957 851 378250 0.677 -0.38991 0.211642 0.447 1.03 0.065432 0.371878 Gynaecology and Obstetrics Hysterectomy (self-reported) T 378957 37549 341552 0.946 -0.05546 0.030167 0.892 1 0.066014 0.371878 Operations and Procedures Lipoma removed excision of lipoma (self-reported) T 378957 600 378501 1.39 0.329357 0.179368 0.978 1.98 0.066326 0.371878 Operations and Procedures Other biopsy of skin T 378957 1597 377504 1.24 0.214022 0.116483 0.986 1.56 0.066157 0.371878 Operations and Procedures Other open repair of ligament T 378957 420 378681 0.539 -0.61893 0.337135 0.278 1.04 0.066379 0.371878 Musculoskeletal Fracture forearm wrist (HES and self-reported) T 378957 8702 370399 0.898 -0.10712 0.058302 0.801 1.01 0.066175 0.371878 Operations and Procedures Operations on hydrocele sac T 378957 1029 378072 1.3 0.262267 0.142968 0.982 1.72 0.066588 0.372182 Operations and Procedures Diagnostic endoscopic examination of knee joint T 378957 3016 376085 0.829 -0.18765 0.102555 0.678 1.01 0.067283 0.375198 Operations and Procedures Bone and intramedullary fixation T 378957 2523 376578 0.814 -0.20577 0.112614 0.653 1.02 0.067666 0.376462 Operations and Procedures Opening of abdomen T 378957 940 378161 1.31 0.270455 0.148482 0.98 1.75 0.068536 0.380261 Neurosciences Benign essential tremor (HES and self-reported) T 378957 270 378831 0.44 -0.82182 0.451395 0.181 1.06 0.068665 0.380261 Immuno-inflammation Other erythematous conditions (HES) T 378957 481 378620 1.43 0.360511 0.198365 0.972 2.12 0.069154 0.382089 Other Pack years T 110892 NA NA NA -0.0281 0.015488 -0.05845 0.00226 0.069661 0.384013 Neurosciences Nerve root and plexus compressions (HES) T 378957 3581 375520 0.846 -0.16773 0.092522 0.705 1.01 0.069853 0.38419 Operations and Procedures Other therapeutic endoscopic operations on ureter T 378957 1932 377169 1.21 0.19392 0.107249 0.984 1.5 0.070585 0.387335 Operations and Procedures Intracranial haematoma drainage (self-reported) T 378957 205 378896 1.68 0.518282 0.286868 0.957 2.95 0.07081 0.387685 Gynaecology and Obstetrics Fertility treatment procedures (self-reported) T 378957 966 378135 0.707 -0.34686 0.19222 0.485 1.03 0.071154 0.388682 Operations and Procedures Therapeutic epidural injection T 378957 4695 374406 0.866 -0.14405 0.079989 0.74 1.01 0.071734 0.390398 Operations and Procedures Repair of muscle T 378957 2257 376844 1.2 0.179158 0.099508 0.984 1.45 0.071792 0.390398 Neurosciences Facial nerve disorders (HES) T 378957 777 378324 1.33 0.28876 0.160765 0.974 1.83 0.072469 0.391041 Cardiovascular Essential primary hypertension (HES) T 378957 70382 308719 0.961 -0.04022 0.022363 0.919 1 0.072079 0.391041 Cardiovascular Varicose vein surgery (self-reported) T 378957 15382 363719 1.08 0.073668 0.041027 0.993 1.17 0.072559 0.391041 Operations and Procedures Arteriotomy approach to organ under image control T 378957 426 378675 0.562 -0.57568 0.320279 0.3 1.05 0.072268 0.391041 Medication Lipid modifying agents combinations T 378957 72923 306178 0.961 -0.04021 0.022502 0.919 1 0.07393 0.395863 Summary Other diseases of pleura (HES) T 378957 6040 373061 1.12 0.113156 0.063294 0.989 1.27 0.073811 0.395863 Summary Congenital malformations of eye ear face and neck (HES) T 378957 307 378794 0.479 -0.73671 0.41243 0.213 1.07 0.074057 0.395863 Summary HESCH Certain infectious and parasitic diseases BIN (HES) T 378957 26714 352387 1.06 0.056954 0.031931 0.994 1.13 0.074476 0.395863 Neurosciences Disorders of autonomic nervous system (HES) T 378957 241 378860 0.407 -0.89827 0.503931 0.152 1.09 0.074664 0.395863 Musculoskeletal Other dorsopathies (HES) T 378957 482 378619 1.43 0.354277 0.19838 0.966 2.1 0.074123 0.395863 Operations and Procedures Reduction or fixation of bone fracture (self-reported) T 378957 17474 361627 1.07 0.068937 0.038662 0.993 1.16 0.074572 0.395863 Operations and Procedures Other repair of lip T 378957 211 378890 0.355 -1.03463 0.581625 0.114 1.11 0.075262 0.395863 Operations and Procedures Other vein related operations T 378957 4293 374808 1.14 0.13186 0.074032 0.987 1.32 0.074891 0.395863 Operations and Procedures Diagnostic imaging of abdomen T 378957 2458 376643 1.19 0.171454 0.09636 0.983 1.43 0.07519 0.395863 Digestive system Gastritisgastric erosions (HES and self-reported) T 378957 21127 357974 0.935 -0.06692 0.037582 0.869 1.01 0.074964 0.395863 Family history Breast cancer (family history - sibling) T 298527 4866 293787 0.869 -0.14012 0.078885 0.745 1.01 0.075696 0.397281 Metabolic Insulin dependent diabetes mellitus (HES) T 378957 2572 376529 0.822 -0.19646 0.110687 0.661 1.02 0.075915 0.397565 Summary Hypertensive diseases (HES) T 378957 70604 308497 0.961 -0.03954 0.022334 0.92 1 0.076695 0.400519 Neurosciences Hip pain T 378087 48240 329991 0.956 -0.04504 0.02547 0.909 1 0.076978 0.400519 Respiratory Bronchitis (HES and self-reported) T 378957 3358 375743 0.844 -0.16933 0.095697 0.7 1.02 0.076814 0.400519 Operations and Procedures Prosthesis for breast T 378957 1450 377651 0.765 -0.26843 0.151904 0.568 1.03 0.07721 0.400859 Eye Other disorders of iris and ciliary body (HES) T 378957 272 378829 1.56 0.44195 0.250809 0.952 2.54 0.078052 0.401714 Genitourinary Other disorders of urethra (HES) T 378957 692 378409 1.35 0.298163 0.169298 0.967 1.88 0.078208 0.401714 Operations and Procedures Arthroscopy nos (self-reported) T 378957 8377 370724 0.901 -0.10462 0.059279 0.802 1.01 0.077582 0.401714 Operations and Procedures Percutaneous transluminal balloon T 378957 5594 373507 0.879 -0.12912 0.073259 0.761 1.01 0.07798 0.401714 Neurosciences Maximum digits remembered correctly T 116599 NA NA NA 0.026116 0.014825 -0.00294 0.055173 0.07813 0.401714 Operations and Procedures Knee replacement revision (self-reported) T 378957 4614 374487 0.868 -0.141 0.080256 0.742 1.02 0.078938 0.403043 Respiratory Bring up phlegm sputum mucus on most days T 95656 8125 87571 0.898 -0.10793 0.061417 0.796 1.01 0.078855 0.403043 Operations and Procedures Opening into gastrointestinal tract T 378957 207 378894 0.36 -1.02185 0.581716 0.115 1.13 0.078984 0.403043 Infectious disease Hivaids (HES and self-reported) T 378957 309 378792 1.53 0.427575 0.243532 0.951 2.47 0.079136 0.403043 ENT Hearing aid user T 230464 11351 219204 1.09 0.083814 0.04785 0.99 1.19 0.079843 0.405678 Operations and Procedures Diagnostic microendoscopic examination of larynx T 378957 246 378855 0.415 -0.88059 0.503822 0.154 1.11 0.080494 0.405678 Operations and Procedures Repair of recurrent incisional hernia T 378957 225 378876 1.62 0.48286 0.276264 0.943 2.79 0.080496 0.405678 Immuno-inflammation Connective tissue disorder (HES and self-reported) T 378957 2304 376797 1.19 0.172594 0.098676 0.979 1.44 0.080274 0.405678 Genitourinary Polycystic kidney (HES and self-reported) T 378957 1630 377471 1.22 0.202406 0.115768 0.976 1.54 0.080399 0.405678 Eye Other serious eye condition T 124323 6929 117447 0.892 -0.11433 0.065466 0.785 1.01 0.080737 0.406046 Haematology Pancytopenia (HES and self-reported) T 378957 406 378695 1.46 0.375034 0.214998 0.955 2.22 0.081097 0.407006 ENT Dental tooth surgery (self-reported) T 378957 999 378102 1.29 0.250928 0.144097 0.969 1.7 0.081618 0.408769 Operations and Procedures Excision of nail T 378957 608 378493 1.37 0.315157 0.181903 0.959 1.96 0.083176 0.415706 Operations and Procedures Other total prosthetic replacement of other joint T 378957 332 378769 0.516 -0.66128 0.382188 0.244 1.09 0.083588 0.416903 Summary Urticaria and erythema (HES) T 378957 948 378153 1.29 0.256553 0.148443 0.966 1.73 0.083936 0.41691 Operations and Procedures Gestational age T 378957 395 378706 1.46 0.376727 0.217871 0.951 2.23 0.083786 0.41691 Summary Neurotic stress related and somatoform disorders (HES) T 378957 6748 372353 0.892 -0.1144 0.066302 0.783 1.02 0.084447 0.41783 Operations and Procedures Drainage of organ NOC T 378957 2627 376474 1.17 0.160691 0.093136 0.978 1.41 0.084468 0.41783 Immuno-inflammation Other disorders of skin and subcutaneous tissue (HES) T 378957 5075 374026 1.13 0.118107 0.068626 0.984 1.29 0.085247 0.42082 Haematology Agranulocytosis (HES) T 378957 2906 376195 1.17 0.152938 0.088921 0.979 1.39 0.085443 0.420924 Genitourinary Noninflammatory ovary fallop (HES) T 378957 4666 374435 0.871 -0.13763 0.08022 0.745 1.02 0.086232 0.423947 Cancer Mal neo oesophagus (cancer register) T 378957 516 378585 0.618 -0.48188 0.281219 0.356 1.07 0.086613 0.424715 Operations and Procedures Obliteration of cavity of organ NOC T 378957 637 378464 0.656 -0.4212 0.246044 0.405 1.06 0.086918 0.424715 Digestive system Bowel intestinal perforation (HES and self-reported) T 378957 387 378714 1.46 0.376307 0.21982 0.947 2.24 0.086917 0.424715 Operations and Procedures Suture of skin of head or neck T 378957 774 378327 0.685 -0.37849 0.221468 0.444 1.06 0.087447 0.426435 Operations and Procedures Operations on vitreous body T 378957 3853 375248 1.14 0.132621 0.0778 0.98 1.33 0.088261 0.427847 Infectious disease Helicobacter pylori (HES and self-reported) T 378957 1773 377328 0.79 -0.23621 0.13857 0.602 1.04 0.088269 0.427847 Biological assays Mean reticulocyte volume T 361630 NA NA NA -0.01451 0.008512 -0.0312 0.00217 0.08817 0.427847 Genitourinary Calculus of kidney and ureter (HES) T 378957 4404 374697 0.868 -0.14114 0.083106 0.738 1.02 0.089447 0.432686 Medication Androgens T 378957 555 378546 0.632 -0.45842 0.270961 0.372 1.08 0.090678 0.436887 Metabolic Other disorders of thyroid (HES) T 378957 357 378744 0.546 -0.60543 0.357782 0.271 1.1 0.090612 0.436887 Family history Lung cancer (family history) T 378957 NA NA NA -0.01402 0.008301 -0.03029 0.002249 0.091202 0.437992 Eye Intra ocular pressure corneal compensated right T 81141 NA NA NA -0.02994 0.017729 -0.06469 0.00481 0.091271 0.437992 Summary Suppurative and necrotic conditions of lower respiratory tract (HES) T 378957 346 378755 1.48 0.388899 0.23069 0.939 2.32 0.091833 0.438039 Infectious disease Other septicaemia (HES) T 378957 3387 375714 1.15 0.14004 0.08303 0.978 1.35 0.091676 0.438039 Operations and Procedures Barium meal barium swallow (self-reported) T 378957 221 378880 1.59 0.465761 0.276433 0.927 2.74 0.092008 0.438039 ENT Mouth ulcers T 377502 38476 339170 1.05 0.045694 0.027084 0.993 1.1 0.091574 0.438039 Operations and Procedures Plastic operations on external ear T 378957 299 378802 0.5 -0.69376 0.412523 0.223 1.12 0.092616 0.440061 Digestive system Gastritis and duodenitis (HES) T 378957 26187 352914 0.945 -0.05672 0.033858 0.884 1.01 0.093872 0.441914 Operations and Procedures Oesphageal fundoplication hiatus hernia surgery (self-reported) T 378957 906 378195 0.716 -0.33368 0.199236 0.485 1.06 0.093976 0.441914 Cancer Other types of non Hodgkin s lymphoma (cancer register) T 378957 408 378693 1.43 0.359856 0.214952 0.94 2.18 0.094106 0.441914 Operations and Procedures Other excision of adnexa of uterus T 378957 224 378877 1.59 0.462928 0.276488 0.924 2.73 0.094069 0.441914 Operations and Procedures Radiology procedures T 378957 30410 348691 1.05 0.050432 0.030085 0.992 1.12 0.093676 0.441914 Musculoskeletal Fracture hand (HES and self-reported) T 378957 1148 377953 0.746 -0.29272 0.174366 0.53 1.05 0.093197 0.441914 Digestive system Oesophagitis (HES) T 378957 8251 370850 1.1 0.091925 0.054951 0.984 1.22 0.094359 0.44224 Operations and Procedures Other blood transfusion T 378957 4631 374470 0.874 -0.1343 0.08048 0.747 1.02 0.095182 0.444428 Mental health Obsessive compulsive disorder ocd (HES and self-reported) T 378957 208 378893 1.61 0.478178 0.286733 0.92 2.83 0.09538 0.444428 Neurosciences Prospective memory result T 126215 NA NA NA -0.02375 0.014233 -0.05164 0.00415 0.095228 0.444428 Summary Mycoses (HES) T 378957 2468 376633 1.17 0.160429 0.096341 0.972 1.42 0.095867 0.444978 Infectious disease Candidiasis (HES) T 378957 1983 377118 1.19 0.177657 0.106627 0.969 1.47 0.095683 0.444978 Gynaecology and Obstetrics Haemorrhage in early pregnancy (HES) T 378957 836 378265 0.706 -0.34783 0.209062 0.469 1.06 0.096156 0.445461 Operations and Procedures Puncture of joint T 378957 10120 368981 0.914 -0.08943 0.053809 0.823 1.02 0.096497 0.446184 Musculoskeletal Soft tissue disorders related to use overuse and pressure (HES) T 378957 1500 377601 0.781 -0.24655 0.148489 0.584 1.05 0.096839 0.446203 Genitourinary Female genital prolapse (HES) T 378957 10411 368690 1.09 0.082564 0.049731 0.985 1.2 0.096872 0.446203 Cardiovascular Leg artery angioplasty stent (self-reported) T 378957 443 378658 0.603 -0.50596 0.305665 0.331 1.1 0.097866 0.448445 Eye Macular degeneration T 124323 2870 121506 1.16 0.14882 0.08982 0.973 1.38 0.097547 0.448445 Gynaecology and Obstetrics Endometriosis (HES and self-reported) T 378957 5960 373141 0.89 -0.11684 0.070598 0.775 1.02 0.097917 0.448445 Cardiovascular Cerebral infarction (HES) T 378957 2917 376184 0.844 -0.16996 0.102811 0.69 1.03 0.098314 0.449407 Haematology Other diseases of blood and blood forming organs (HES) T 378957 563 378538 1.36 0.310096 0.18797 0.943 1.97 0.099002 0.451695 Operations and Procedures Other reconstruction of joint T 378957 2374 376727 0.83 -0.18692 0.113477 0.664 1.04 0.099513 0.45317 Respiratory CopdExacerbation GOLD2orHigher T 8822 486 8345 1.41 0.342845 0.208473 0.936 2.12 0.100061 0.454806 Summary Ocular musclesocular movement (HES) T 378957 2672 376429 1.16 0.151585 0.092422 0.971 1.39 0.100977 0.456386 Cardiovascular Ischaemic stroke (HES and self-reported) T 378957 2968 376133 0.846 -0.16709 0.101802 0.693 1.03 0.100734 0.456386 Cancer Bowens disease (HES and self-reported) T 378957 617 378484 1.34 0.294181 0.179312 0.944 1.91 0.100878 0.456386 Summary Neoplasms BIN (cancer register) T 378957 45225 333876 0.958 -0.04288 0.026237 0.91 1.01 0.102195 0.461026 Operations and Procedures Other open operations on bile duct T 378957 1260 377841 1.24 0.214768 0.131632 0.958 1.6 0.102768 0.462744 Operations and Procedures Artificial opening into stomach T 378957 356 378745 0.558 -0.58333 0.357786 0.277 1.13 0.10302 0.462824 Digestive system Pyloric stenosis (HES and self-reported) T 378957 250 378851 1.54 0.43448 0.266605 0.916 2.6 0.10317 0.462824 Summary Disorders of synovium and tendon (HES) T 378957 8361 370740 0.908 -0.096 0.058977 0.809 1.02 0.103589 0.462857 Summary HESCH Diseases of the nervous system (HES) T 378957 36198 342903 0.954 -0.04683 0.028813 0.902 1.01 0.10409 0.462857 Symptoms Hyperhidrosis (HES) T 378957 544 378557 0.644 -0.44026 0.27091 0.379 1.09 0.104138 0.462857 Operations and Procedures Cardiac pacemaker system introduced through vein T 378957 2286 376815 0.827 -0.18978 0.116531 0.658 1.04 0.10341 0.462857 Operations and Procedures Other drainage of peritoneal cavity T 378957 2011 377090 1.19 0.17242 0.106059 0.965 1.46 0.104012 0.462857 Mental health Nervous breakdown (HES and self-reported) T 378957 629 378472 0.671 -0.39902 0.246072 0.414 1.09 0.104902 0.465394 Operations and Procedures Ankle surgery (self-reported) T 378957 1003 378098 0.74 -0.3005 0.18562 0.515 1.07 0.105468 0.465409 Operations and Procedures Operations on nasolacrimal duct T 378957 416 378685 1.42 0.347948 0.214852 0.929 2.16 0.105345 0.465409 Operations and Procedures Total prosthetic replacement of hip joint using cement T 378957 4901 374200 0.881 -0.12668 0.078252 0.756 1.03 0.105485 0.465409 Summary Viral hepatitis (HES) T 378957 525 378576 0.635 -0.45416 0.280982 0.366 1.1 0.10602 0.466914 Biological assays Basophill percentage T 367073 NA NA NA 0.013616 0.008444 -0.00293 0.030166 0.106849 0.469707 Medication Hormonal contraceptives for systemic use T 378957 5576 373525 1.12 0.109933 0.068283 0.976 1.28 0.107406 0.469946 Cancer Mal melanoma of skin (cancer register) T 378957 2611 376490 0.84 -0.174 0.108231 0.68 1.04 0.107901 0.469946 Summary Melanoma and other mal neo of skin (cancer register) T 378957 2611 376490 0.84 -0.174 0.108231 0.68 1.04 0.107901 0.469946 Operations and Procedures Abdominal excision of uterus T 378957 9231 369870 0.913 -0.09106 0.05667 0.817 1.02 0.108074 0.469946 Biological assays Sodium in urine T 367322 NA NA NA -0.01357 0.008442 -0.03012 0.002976 0.107939 0.469946 Respiratory FEV1 FVC ratio strict T 221584 NA NA NA 0.017556 0.010908 -0.00382 0.038935 0.107515 0.469946 Cardiovascular Nonrheumatic aortic valve disorders (HES) T 378957 2314 376787 0.83 -0.18582 0.115755 0.662 1.04 0.108424 0.470227 Neurosciences Back pain T 378087 102012 276219 0.97 -0.03036 0.018918 0.935 1.01 0.108529 0.470227 Operations and Procedures Ureteric surgery (self-reported) T 378957 604 378497 0.666 -0.4062 0.253576 0.405 1.1 0.109185 0.471374 Operations and Procedures Simple extraction of tooth T 378957 2335 376766 0.83 -0.18627 0.116232 0.661 1.04 0.109025 0.471374 Operations and Procedures Other plastic operations on breast T 378957 1690 377411 0.801 -0.222 0.138831 0.61 1.05 0.109807 0.471524 Neurosciences Encephalitis (HES and self-reported) T 378957 415 378686 1.41 0.343552 0.214799 0.925 2.15 0.109728 0.471524 Musculoskeletal Osteoarthritis non load bearing joints T 316942 4872 312194 0.884 -0.12342 0.077122 0.76 1.03 0.109521 0.471524 Operations and Procedures Plastic repair of aortic valve T 378957 1074 378027 0.753 -0.28322 0.17723 0.532 1.07 0.110037 0.471671 Operations and Procedures Other excision of lesion of skin T 378957 31445 347656 1.05 0.047399 0.029692 0.989 1.11 0.110407 0.472416 Medication Lipid modifying agents plain T 378957 93186 285915 0.968 -0.03214 0.020186 0.931 1.01 0.111361 0.472733 Cardiovascular Disorders of circulatory system in disease (HES) T 378957 256 378845 1.53 0.424507 0.266422 0.907 2.58 0.111078 0.472733 Genitourinary Inflammatory disease of cervix uteri (HES) T 378957 1044 378057 0.751 -0.28662 0.179999 0.528 1.07 0.111306 0.472733 Gynaecology and Obstetrics Other complications of labour and delivery (HES) T 378957 696 378405 1.31 0.272664 0.171541 0.938 1.84 0.111948 0.472733 ENT Mouth salivary gland surgery (self-reported) T 378957 2330 376771 0.831 -0.1849 0.116233 0.662 1.04 0.111655 0.472733 ENT Wisdom teeth surgery (self-reported) T 378957 15032 364069 1.07 0.066048 0.041429 0.985 1.16 0.110877 0.472733 Operations and Procedures Other intravenous transfusion T 378957 222 378879 0.449 -0.80113 0.504372 0.167 1.21 0.112202 0.472733 Gynaecology and Obstetrics Vaginal prolapseuterine prolapse (HES and self-reported) T 378957 11476 367625 1.08 0.075798 0.047691 0.982 1.18 0.111981 0.472733 Metabolic Hypopituitarism (HES and self-reported) T 378957 446 378655 0.616 -0.48516 0.305481 0.338 1.12 0.112247 0.472733 Mental health Bipolar II Disorder T 91467 531 90984 0.65 -0.43082 0.271497 0.382 1.11 0.112554 0.473198 Summary Pregnancy with abortive outcome (HES) T 378957 3363 375738 0.858 -0.15353 0.097003 0.709 1.04 0.11348 0.474485 Respiratory Bronchitis not specified as acute or chronic (HES) T 378957 570 378531 0.661 -0.41422 0.261829 0.396 1.1 0.113648 0.474485 Cardiovascular Atrial fibrillation (HES and self-reported) T 378957 2928 376173 0.852 -0.16066 0.101431 0.698 1.04 0.113205 0.474485 Mental health Overall health rating T 377297 NA NA NA -0.0132 0.008336 -0.02954 0.003137 0.11328 0.474485 Musculoskeletal Joint disorder (HES and self-reported) T 378957 27274 351827 0.95 -0.0518 0.032883 0.89 1.01 0.115171 0.480012 Medication Surgical aids T 378957 1057 378044 1.25 0.224677 0.142701 0.946 1.66 0.11538 0.480053 Operations and Procedures Biopsy of breast T 378957 1566 377535 0.797 -0.22672 0.144249 0.601 1.06 0.11602 0.481883 Medication Blood glucose lowering drugs excl insulins T 378957 49513 329588 0.96 -0.0405 0.025814 0.913 1.01 0.116673 0.482602 Digestive system Dyspepsia (HES) T 378957 10739 368362 0.922 -0.08153 0.051982 0.832 1.02 0.116794 0.482602 Operations and Procedures Placement of prosthesis in organ NOC T 378957 3165 375936 0.857 -0.15392 0.0981 0.707 1.04 0.116639 0.482602 Immuno-inflammation Psoriasis (HES and self-reported) T 378957 5583 373518 1.11 0.103893 0.066301 0.974 1.26 0.117117 0.483108 Mental health Other anxiety disorders (HES) T 378957 5413 373688 0.891 -0.11559 0.074003 0.771 1.03 0.118291 0.483647 Digestive system Other disorders of gingiva and edentulous alveolar ridge (HES) T 378957 283 378818 0.525 -0.64416 0.412777 0.234 1.18 0.118631 0.483647 Medication Drugs used in addictive disorders T 378957 648 378453 1.32 0.279801 0.178977 0.931 1.88 0.117975 0.483647 Operations and Procedures Excision of tonsil T 378957 1168 377933 0.765 -0.26822 0.171978 0.546 1.07 0.118854 0.483647 Operations and Procedures Curettage of lesion of skin T 378957 1788 377313 1.19 0.174532 0.111565 0.957 1.48 0.117725 0.483647 Operations and Procedures Other closed reduction of fracture of bone T 378957 1496 377605 0.793 -0.23164 0.148516 0.593 1.06 0.118836 0.483647 Digestive system Other abdominal problem (HES and self-reported) T 378957 39890 339211 0.958 -0.04333 0.027723 0.907 1.01 0.118096 0.483647 Musculoskeletal Dupuytrens contracture (HES and self-reported) T 378957 3300 375801 1.14 0.132378 0.08468 0.967 1.35 0.117989 0.483647 Mental health Ever highly irritable argumentative for 2 days T 123697 22263 101496 0.942 -0.06008 0.038647 0.873 1.02 0.120012 0.487536 Summary HESCH Endocrine nutritional and metabolic diseases BIN (HES) T 378957 66768 312333 0.966 -0.03483 0.022446 0.924 1.01 0.120684 0.488825 Immuno-inflammation Ulcer of lower limb (HES) T 378957 989 378112 0.75 -0.28821 0.185739 0.521 1.08 0.120735 0.488825 Cardiovascular Varicose veins (HES and self-reported) T 378957 11798 367303 1.07 0.072134 0.046594 0.981 1.18 0.121586 0.491444 Operations and Procedures Primary excision of lumbar intervertebral disc T 378957 1796 377305 0.813 -0.20699 0.133791 0.625 1.06 0.121846 0.49167 Genitourinary Kidney stoneureter stonebladder stone (HES and self-reported) T 378957 6694 372407 0.903 -0.10243 0.066318 0.793 1.03 0.122466 0.493278 Digestive system Dyspepsia indigestion (HES and self-reported) T 378957 11162 367939 0.924 -0.07863 0.050934 0.837 1.02 0.122654 0.493278 Cardiovascular Angiogram not coronary (self-reported) T 378957 345 378756 0.576 -0.55155 0.357909 0.286 1.16 0.123307 0.495078 Operations and Procedures Other operations on urethra T 378957 1489 377612 0.796 -0.22846 0.148522 0.595 1.06 0.123988 0.496984 Operations and Procedures Open drainage of bladder T 378957 606 378495 1.32 0.279652 0.181946 0.926 1.89 0.124291 0.49737 Medication Psycholeptics and psychoanaleptics in combination T 378957 12227 366874 0.928 -0.07471 0.04868 0.844 1.02 0.124839 0.497969 Operations and Procedures Other operations on mouth T 378957 1260 377841 0.779 -0.25009 0.162957 0.566 1.07 0.124854 0.497969 Summary Pulmonary heart disease and diseases of pulmonary circulation (HES) T 378957 3992 375109 1.13 0.118078 0.077074 0.968 1.31 0.125521 0.498155 Summary Diseases of veins lymphatic vessels (HES) T 378957 35400 343701 1.04 0.043231 0.028216 0.988 1.1 0.125479 0.498155 Cancer Rectal cancer (self-reported) T 378957 274 378827 1.48 0.395159 0.257933 0.895 2.46 0.125518 0.498155 Medication Drugs for peptic ulcer and gastro oesophageal reflux disease gord T 378957 45634 333467 0.961 -0.03996 0.026212 0.913 1.01 0.127369 0.501359 Metabolic Ovarian dysfunction (HES) T 378957 239 378862 0.501 -0.6905 0.452466 0.207 1.22 0.126989 0.501359 Cancer Neo of other sites (cancer register) T 378957 206 378895 0.463 -0.77011 0.505091 0.172 1.25 0.127334 0.501359 Operations and Procedures Therapeutic transluminal operations on other artery T 378957 774 378327 0.719 -0.33029 0.216516 0.47 1.1 0.127145 0.501359 Operations and Procedures Endovascular placement of stent T 378957 370 378731 0.597 -0.51526 0.33772 0.308 1.16 0.127083 0.501359 Metabolic Thyroid goitre (HES and self-reported) T 378957 1793 377308 0.817 -0.20232 0.132798 0.63 1.06 0.127632 0.501575 Operations and Procedures Artificial opening into jejunum T 378957 294 378807 1.46 0.38031 0.250202 0.896 2.39 0.128508 0.504195 Haematology Low plateletsplatelet disorder (HES and self-reported) T 378957 1618 377483 1.2 0.178629 0.117871 0.949 1.51 0.129657 0.507876 Digestive system Unspecified abdominal hernia (HES) T 378957 276 378825 0.535 -0.62466 0.4129 0.238 1.2 0.130318 0.508303 Metabolic Thyroid surgery (self-reported) T 378957 586 378515 1.32 0.279733 0.184943 0.921 1.9 0.130399 0.508303 Operations and Procedures Primary open reduction of traumatic dislocation of joint T 378957 347 378754 1.43 0.357339 0.236226 0.9 2.27 0.130356 0.508303 Neurosciences Other nervous system in diseases classified elsewhere (HES) T 378957 960 378141 0.752 -0.28451 0.18882 0.52 1.09 0.131861 0.510906 Operations and Procedures Examination of bile duct and pancreatic duct T 378957 2192 376909 1.17 0.154228 0.102342 0.955 1.43 0.131815 0.510906 Cardiovascular Transient ischaemic attack tia (HES and self-reported) T 378957 3570 375531 1.13 0.122925 0.081591 0.964 1.33 0.131915 0.510906 Digestive system Oesophagitisbarretts oesophagus (HES and self-reported) T 378957 10521 368580 1.08 0.074278 0.049266 0.978 1.19 0.13163 0.510906 Gynaecology and Obstetrics Preterm delivery (HES) T 378957 602 378499 1.32 0.276417 0.183988 0.919 1.89 0.133003 0.512728 Operations and Procedures Packing of cavity of nose T 378957 1016 378085 1.24 0.218481 0.145432 0.936 1.65 0.133024 0.512728 Infectious disease Herpes simplex (HES and self-reported) T 378957 373 378728 0.602 -0.50749 0.337608 0.311 1.17 0.132793 0.512728 Digestive system Other diseases of intestine (HES) T 378957 13086 366015 0.932 -0.07072 0.047136 0.85 1.02 0.133516 0.513332 Cardiovascular Mean carotid IMT intima medial thickness at 150 degrees T 1843 NA NA NA 0.186925 0.124614 -0.05732 0.431168 0.133607 0.513332 Operations and Procedures Diagnostic endos exam of lwr resp trct rigid brnchscpe T 378957 452 378649 1.37 0.314941 0.210077 0.908 2.07 0.133831 0.513374 Medication Ace inhibitors plain T 378957 38569 340532 0.958 -0.04251 0.028393 0.907 1.01 0.134387 0.514358 Musculoskeletal Fractured broken bones in last 5 years T 376884 36458 340570 1.04 0.041639 0.027828 0.987 1.1 0.134582 0.514358 Cardiovascular Cholesterol lowering medication T 376081 64923 311299 0.966 -0.03507 0.023445 0.922 1.01 0.134728 0.514358 Biological assays Lymphocyte percentage T 367073 NA NA NA 0.012624 0.008445 -0.00393 0.029176 0.134965 0.514447 Cardiovascular Coronary angioplasty ptca stent (self-reported) T 378957 3922 375179 0.878 -0.13038 0.087284 0.74 1.04 0.135254 0.514734 Eye LogMAR final right T 83968 NA NA NA 0.025952 0.017423 -0.0082 0.060101 0.136346 0.518072 Musculoskeletal Psoriatic arthropathy (HES and self-reported) T 378957 1087 378014 1.24 0.211764 0.142422 0.935 1.63 0.137049 0.519923 Neurosciences Alzheimer s disease (HES) T 378957 359 378742 1.41 0.341188 0.230595 0.895 2.21 0.13898 0.525593 Mental health Risk taking T 365508 96122 269526 1.03 0.02895 0.01956 0.991 1.07 0.138865 0.525593 ENT Suppurative and unspecified otitis media (HES) T 378957 700 378401 1.29 0.25666 0.173699 0.92 1.82 0.139511 0.52595 Operations and Procedures Other bowel surgery (self-reported) T 378957 2282 376819 0.842 -0.17187 0.116291 0.67 1.06 0.139424 0.52595 Medication Potassium sparing agents T 378957 950 378151 0.757 -0.27833 0.188901 0.523 1.1 0.140643 0.525982 Infectious disease Streptococcal septicaemia (HES) T 378957 235 378866 0.514 -0.6654 0.452066 0.212 1.25 0.141048 0.525982 Gynaecology and Obstetrics Abnormalities of forces of labour (HES) T 378957 405 378696 0.636 -0.45327 0.307324 0.348 1.16 0.140243 0.525982 Operations and Procedures Liver surgery (self-reported) T 378957 301 378800 1.44 0.367984 0.249977 0.885 2.36 0.141001 0.525982 Operations and Procedures Other upper digestive tract T 378957 488 378613 1.35 0.297405 0.201858 0.906 2 0.140661 0.525982 Operations and Procedures Branch of external carotid artery T 378957 271 378830 1.46 0.3811 0.258119 0.883 2.43 0.139823 0.525982 Operations and Procedures Bilateral excision of adnexa of uterus T 378957 8743 370358 0.918 -0.08525 0.057888 0.82 1.03 0.140834 0.525982 Operations and Procedures Gallstones removed (self-reported) T 378957 315 378786 1.43 0.357432 0.243108 0.888 2.3 0.141492 0.526823 Operations and Procedures High cost other cardiovascular drugs T 378957 535 378566 1.33 0.285506 0.194461 0.909 1.95 0.142053 0.528095 Family history Stroke (family history - father) T 343458 51292 292300 0.964 -0.03639 0.024821 0.918 1.01 0.142628 0.529416 Family history Parkinson s disease (family history - father) T 338597 8344 330385 0.918 -0.08575 0.058596 0.818 1.03 0.143344 0.530972 Operations and Procedures Placement of stent in organ NOC T 378957 1320 377781 1.21 0.18956 0.129576 0.938 1.56 0.143488 0.530972 Operations and Procedures Other operations on outlet of male bladder T 378957 6418 372683 0.906 -0.09926 0.067962 0.793 1.03 0.144139 0.532563 Haematology Other aplastic anaemias (HES) T 378957 409 378692 1.38 0.319799 0.219484 0.895 2.12 0.145102 0.532852 Cardiovascular Phlebitis and thrombophlebitis (HES) T 378957 3502 375599 1.13 0.119861 0.082193 0.96 1.32 0.144762 0.532852 Musculoskeletal Pagets disease (HES and self-reported) T 378957 272 378829 0.548 -0.60195 0.412969 0.244 1.23 0.144946 0.532852 Musculoskeletal Systemic lupus erythematosissle (HES and self-reported) T 378957 547 378554 1.33 0.283607 0.194371 0.907 1.94 0.144537 0.532852 Eye Disorders of globe (HES) T 378957 389 378712 1.38 0.320108 0.219823 0.895 2.12 0.145336 0.532899 Operations and Procedures Reconstruction of breast T 378957 1391 377710 0.802 -0.22111 0.152011 0.595 1.08 0.145788 0.533744 Symptoms Abnormalities of heart beat (HES) T 378957 7716 371385 0.915 -0.08911 0.061339 0.811 1.03 0.146301 0.533999 ENT Toothache T 377502 15330 362316 1.06 0.060128 0.041382 0.979 1.15 0.146225 0.533999 Gynaecology and Obstetrics Cone biopsy (self-reported) T 378957 3152 375949 0.868 -0.14121 0.097341 0.717 1.05 0.146868 0.535257 Genitourinary Scrotal problem not cancer (HES and self-reported) T 378957 1382 377719 1.2 0.185123 0.127756 0.937 1.55 0.147329 0.536126 Biological assays Lymphocyte count T 367067 NA NA NA 0.012206 0.008441 -0.00434 0.028751 0.148153 0.538312 Cardiovascular Rheumatic tricuspid valve diseases (HES) T 378957 262 378839 1.47 0.383673 0.266211 0.871 2.47 0.149518 0.539259 Immuno-inflammation Atrophic disorders of skin (HES) T 378957 2542 376559 1.15 0.137638 0.095495 0.952 1.38 0.149494 0.539259 Operations and Procedures Endoscopic of lower bowel T 378957 3536 375565 0.876 -0.13265 0.091931 0.731 1.05 0.149036 0.539259 Genitourinary Other renalkidney problem (HES and self-reported) T 378957 5423 373678 1.1 0.096813 0.067176 0.966 1.26 0.149533 0.539259 Biological assays Basophill count T 367067 NA NA NA 0.01215 0.008413 -0.00434 0.028638 0.148663 0.539259 ENT Tinnitus tiniitis (HES and self-reported) T 378957 1088 378013 1.23 0.203095 0.14119 0.929 1.62 0.150307 0.540803 Musculoskeletal Fracture ulna (HES and self-reported) T 378957 1643 377458 0.819 -0.19943 0.138678 0.624 1.08 0.15041 0.540803 Medication Other diagnostic radiopharmaceuticals T 378957 3824 375277 0.881 -0.12691 0.088395 0.741 1.05 0.151072 0.541566 Operations and Procedures Therapeutic on outlet of female bladder T 378957 299 378802 0.577 -0.54958 0.382729 0.273 1.22 0.151015 0.541566 Cardiovascular Aortic valve disease (HES and self-reported) T 378957 2405 376696 0.851 -0.16095 0.112279 0.683 1.06 0.151728 0.54311 Summary Congenital malformations musculoskeletal system (HES) T 378957 711 378390 0.728 -0.31704 0.221743 0.472 1.12 0.152787 0.544519 Cardiovascular Pulmonary embolism (HES) T 378957 3296 375805 1.13 0.120922 0.084641 0.956 1.33 0.153106 0.544519 Cardiovascular Stroke not specified as haemorrhage or infarction (HES) T 378957 968 378133 1.24 0.214173 0.149967 0.923 1.66 0.153252 0.544519 Operations and Procedures Other operations on oesophagus T 378957 1839 377262 0.828 -0.18819 0.131574 0.64 1.07 0.152639 0.544519 Medication Ibuprofen e g Nurofen T 374624 55904 318864 1.03 0.033609 0.023518 0.988 1.08 0.152976 0.544519 Genitourinary Other disorders of male genital organs (HES) T 378957 2588 376513 1.15 0.137092 0.09627 0.95 1.39 0.154435 0.546306 Operations and Procedures Incision of tongue T 378957 994 378107 1.24 0.211095 0.148262 0.924 1.65 0.154505 0.546306 Operations and Procedures Injection of therapeutic substance into organ NOC T 378957 608 378493 0.704 -0.35039 0.246188 0.435 1.14 0.154662 0.546306 Operations and Procedures Approach through abdominal cavity T 378957 6488 372613 1.09 0.088035 0.061796 0.967 1.23 0.154269 0.546306 Operations and Procedures Other release of peripheral nerve T 378957 324 378777 1.41 0.344904 0.242807 0.877 2.27 0.155465 0.548338 Cancer Neo of oral cavity and digestive (cancer register) T 378957 341 378760 1.4 0.335363 0.236397 0.88 2.22 0.156003 0.549432 Operations and Procedures Diagnostic endoscopic examination of colon T 378957 48889 330212 0.965 -0.03585 0.025304 0.918 1.01 0.156567 0.549655 Operations and Procedures Transluminal operations on renal artery T 378957 241 378860 1.48 0.390466 0.275655 0.861 2.54 0.156629 0.549655 Biological assays Creatinine enzymatic in urine T 368096 NA NA NA -0.01195 0.008439 -0.02849 0.00459 0.156751 0.549655 Operations and Procedures Transluminal operations on iliac artery T 378957 580 378521 0.698 -0.35915 0.253914 0.425 1.15 0.157228 0.550035 Haematology Clotting disorderexcessive bleeding (HES and self-reported) T 378957 2706 376395 1.14 0.131629 0.093079 0.95 1.37 0.157316 0.550035 Operations and Procedures Combined operations on muscles of eye T 378957 370 378731 1.38 0.325077 0.230158 0.882 2.17 0.15783 0.551033 Medication Fish oil including cod liver oil T 377706 119641 258209 0.975 -0.0258 0.018276 0.94 1.01 0.158089 0.551138 Operations and Procedures Diagnostic endoscopic examination of lower bowel T 378957 29456 349645 0.956 -0.0447 0.03173 0.899 1.02 0.158923 0.552753 Operations and Procedures Other lymph node T 378957 2930 376171 0.867 -0.14217 0.100942 0.712 1.06 0.159011 0.552753 Symptoms Pain associated with micturition (HES) T 378957 1067 378034 0.78 -0.24876 0.177089 0.551 1.1 0.160099 0.555733 Cardiovascular Heart failurepulmonary odema (HES and self-reported) T 378957 5221 373880 0.9 -0.10526 0.074996 0.777 1.04 0.160464 0.556198 Musculoskeletal Fracture neck of femur hip (HES and self-reported) T 378957 2221 376880 1.15 0.142783 0.101856 0.945 1.41 0.160971 0.557154 Cardiovascular Paroxysmal tachycardia (HES) T 378957 2977 376124 0.869 -0.14028 0.100252 0.714 1.06 0.16173 0.558177 Summary Mal neo of ill secondary unspecified (cancer register) T 378957 433 378668 1.35 0.30037 0.214574 0.887 2.06 0.16156 0.558177 Medication Estrogens T 378957 10090 369011 0.928 -0.07488 0.053643 0.835 1.03 0.162722 0.558322 Summary Symptoms and signs involving speech and voice (HES) T 378957 2293 376808 0.852 -0.1607 0.115585 0.679 1.07 0.164444 0.558322 Digestive system Other functional intestinal disorders (HES) T 378957 10172 368929 0.929 -0.07412 0.053381 0.836 1.03 0.164999 0.558322 Gynaecology and Obstetrics Medical abortion (HES) T 378957 998 378103 0.774 -0.2557 0.184294 0.54 1.11 0.165305 0.558322 Gynaecology and Obstetrics Breast surgery (self-reported) T 378957 1320 377781 0.806 -0.21583 0.155514 0.594 1.09 0.165177 0.558322 Operations and Procedures Hip surgery not replacement (self-reported) T 378957 1523 377578 1.18 0.168788 0.121094 0.934 1.5 0.163359 0.558322 ENT Tympanic membrane surgery ear drum repair (self-reported) T 378957 602 378499 1.29 0.257477 0.184698 0.901 1.86 0.163304 0.558322 Family history Alzheimer s disease dementia (family history - sibling) T 300905 1677 299352 0.827 -0.18963 0.136644 0.633 1.08 0.165202 0.558322 Operations and Procedures Therapeutic endoscopic operations on calculus of kidney T 378957 417 378684 0.654 -0.42408 0.305785 0.359 1.19 0.165482 0.558322 Operations and Procedures Diagnostic endoscopic examination of bladder T 378957 30109 348992 1.04 0.042698 0.030553 0.983 1.11 0.162252 0.558322 Operations and Procedures High cost haematology and nutrition drugs T 378957 606 378495 1.29 0.255984 0.184678 0.899 1.86 0.165712 0.558322 Operations and Procedures Injection of other substance into organ NOC T 378957 1838 377263 0.834 -0.181 0.129555 0.647 1.08 0.162394 0.558322 NA Subarachnoid haemorrhage T 378957 982 378119 1.23 0.208587 0.149801 0.918 1.65 0.163794 0.558322 Neurosciences Meningitis (HES and self-reported) T 378957 1714 377387 0.829 -0.18778 0.13501 0.636 1.08 0.16427 0.558322 Digestive system Diverticular diseasediverticulitis (HES and self-reported) T 378957 26531 352570 0.954 -0.04673 0.033521 0.894 1.02 0.163277 0.558322 Neurosciences Polio poliomyelitis (HES and self-reported) T 378957 280 378821 0.588 -0.53083 0.382952 0.278 1.25 0.165698 0.558322 Digestive system Bowel intestinal infarction (HES and self-reported) T 378957 264 378837 0.564 -0.57347 0.413106 0.251 1.27 0.165081 0.558322 Summary Other disorders of the skin and subcutaneous tissue (HES) T 378957 14568 364533 1.06 0.058335 0.042222 0.976 1.15 0.167086 0.559042 Symptoms Abnormal serum enzyme levels (HES) T 378957 226 378875 1.49 0.395794 0.285985 0.848 2.6 0.166368 0.559042 Gynaecology and Obstetrics Mastectomy (self-reported) T 378957 3844 375257 0.886 -0.12097 0.087551 0.746 1.05 0.167078 0.559042 Operations and Procedures Haemorroidectomy piles surgery banding of piles (self-reported) T 378957 6713 372388 1.09 0.084213 0.060893 0.965 1.23 0.166672 0.559042 Family history Bowel cancer (family history - sibling) T 301109 7001 294235 0.914 -0.0895 0.064707 0.805 1.04 0.166615 0.559042 Medication Androgens and female sex hormones in combination T 378957 421 378680 0.656 -0.4214 0.30576 0.36 1.19 0.168135 0.55941 Eye Retinal disorders in diseases classified elsewhere (HES) T 378957 1229 377872 0.801 -0.22192 0.161106 0.584 1.1 0.168357 0.55941 Gynaecology and Obstetrics Salpingectomy (self-reported) T 378957 258 378843 0.565 -0.57033 0.413332 0.251 1.27 0.167636 0.55941 Operations and Procedures Operations on external nose T 378957 3310 375791 1.12 0.116629 0.084627 0.952 1.33 0.168158 0.55941 Mental health Depression (HES and self-reported) T 378957 27882 351219 0.956 -0.04487 0.032561 0.897 1.02 0.168174 0.55941 Musculoskeletal Other systemic involvement of connective tissue (HES) T 378957 1710 377391 1.17 0.158198 0.115037 0.935 1.47 0.169071 0.561008 Summary Disorders of muscles (HES) T 378957 1025 378076 0.781 -0.24671 0.179866 0.549 1.11 0.170171 0.561663 Genitourinary Pain with female genital (HES) T 378957 3073 376028 0.873 -0.13542 0.098588 0.72 1.06 0.169556 0.561663 ENT Loose teeth T 377502 15091 362555 0.942 -0.06002 0.043762 0.864 1.03 0.170201 0.561663 Digestive system Femoral hernia (HES and self-reported) T 378957 643 378458 0.726 -0.31981 0.233112 0.46 1.15 0.170086 0.561663 Operations and Procedures Excision of vas deferens T 378957 4286 374815 0.887 -0.1194 0.08729 0.748 1.05 0.171369 0.564744 Genitourinary Urethral stricture (HES) T 378957 2967 376134 0.871 -0.13762 0.100733 0.715 1.06 0.171891 0.56569 Operations and Procedures Closed reduction of fracture of bone and external fixation T 378957 391 378710 0.646 -0.43757 0.320542 0.344 1.21 0.172224 0.566013 Medication Progestogens and estrogens in combination T 378957 8666 370435 1.08 0.074308 0.054616 0.968 1.2 0.173653 0.567844 Operations and Procedures Exenteration of mastoid air cells T 378957 445 378656 1.34 0.29162 0.214374 0.879 2.04 0.173724 0.567844 Operations and Procedures Other operations on rectum T 378957 894 378207 1.24 0.213246 0.156657 0.91 1.68 0.173443 0.567844 Operations and Procedures Percutaneous puncture of kidney T 378957 1437 377664 1.19 0.170905 0.125489 0.928 1.52 0.173227 0.567844 Eye Iritis (HES and self-reported) T 378957 479 378622 1.32 0.279423 0.205714 0.884 1.98 0.174366 0.5684 Neurosciences Meningioma benign meningeal tumour (HES and self-reported) T 378957 499 378602 0.692 -0.36867 0.271325 0.406 1.18 0.174218 0.5684 Medication Antidepressants T 378957 29214 349887 0.958 -0.04315 0.031841 0.9 1.02 0.175346 0.570822 Digestive system Cysts of oral region (HES) T 378957 377 378724 0.649 -0.43303 0.320695 0.346 1.22 0.176922 0.5744 Symptoms Disturbances of skin sensation (HES) T 378957 2617 376484 0.865 -0.14534 0.107632 0.7 1.07 0.176906 0.5744 Medication Antipruritics incl antihistamines anesthetics etc T 378957 592 378509 1.29 0.253218 0.187664 0.892 1.86 0.177236 0.574645 Medication Chemotherapeutics for topical use T 378957 1020 378081 0.785 -0.24237 0.179791 0.552 1.12 0.177632 0.575155 Genitourinary Other abnormal uterine and vaginal bleeding (HES) T 378957 3736 375365 0.887 -0.12006 0.08919 0.745 1.06 0.178267 0.576437 Summary Other bacterial diseases (HES) T 378957 4393 374708 1.11 0.09993 0.0744 0.955 1.28 0.179227 0.577082 Haematology Purpura and other haemorrhagic conditions (HES) T 378957 1530 377571 1.18 0.16348 0.121901 0.927 1.5 0.179891 0.577082 Metabolic Obesity (HES) T 378957 9864 369237 0.93 -0.07248 0.053913 0.837 1.03 0.178809 0.577082 Cancer Bladder cancer (self-reported) T 378957 892 378209 1.23 0.208456 0.15515 0.909 1.67 0.179087 0.577082 Operations and Procedures Removal of mole skin lesion (self-reported) T 378957 5310 373791 1.1 0.0914 0.068107 0.959 1.25 0.179595 0.577082 Musculoskeletal Back problem (HES and self-reported) T 378957 11524 367577 0.935 -0.06685 0.049853 0.848 1.03 0.179904 0.577082 Musculoskeletal Fracture fibula (HES and self-reported) T 378957 749 378352 1.25 0.225812 0.168918 0.9 1.75 0.181284 0.580736 Medication Antithrombotic agents T 378957 59142 319959 0.968 -0.03209 0.024033 0.924 1.02 0.181737 0.581077 Medication Paracetamol T 374624 81842 292926 1.03 0.027078 0.020283 0.987 1.07 0.181873 0.581077 Genitourinary Anal fissure (HES and self-reported) T 378957 269 378832 1.42 0.354143 0.265976 0.846 2.4 0.183029 0.583996 Cardiovascular Carotid artery surgery endarterectomy (self-reported) T 378957 226 378875 0.548 -0.6017 0.452496 0.226 1.33 0.183607 0.585065 Operations and Procedures Renal kidney transplant (self-reported) T 378957 252 378849 1.44 0.365637 0.275282 0.84 2.47 0.184104 0.585874 Family history Father s age at death T 278443 NA NA NA 0.012808 0.009662 -0.00613 0.031746 0.184969 0.58785 Operations and Procedures Hand finger surgery (self-reported) T 378957 1664 377437 0.835 -0.18046 0.136264 0.639 1.09 0.185395 0.588417 Operations and Procedures Extirpation of lesion of bone T 378957 466 378635 0.689 -0.37249 0.281419 0.397 1.2 0.185636 0.588417 Musculoskeletal Osteonecrosis (HES) T 378957 512 378589 1.3 0.2661 0.201556 0.879 1.94 0.18676 0.590426 Immuno-inflammation Chronic skin ulcers (HES and self-reported) T 378957 1331 377770 0.816 -0.20292 0.153674 0.604 1.1 0.186674 0.590426 Family history Bowel cancer (family history) T 378957 NA NA NA -0.01092 0.008285 -0.02716 0.005318 0.187452 0.591837 Eye Other strabismus (HES) T 378957 823 378278 1.24 0.213913 0.162385 0.901 1.7 0.187732 0.591946 Neurosciences Other disorders of brain (HES) T 378957 1438 377663 1.18 0.16504 0.125448 0.922 1.51 0.188307 0.592162 Operations and Procedures Repair of other hernia of abdominal wall T 378957 1344 377757 1.19 0.170118 0.129375 0.92 1.53 0.188538 0.592162 Infectious disease Measles morbillivirus (HES and self-reported) T 378957 1296 377805 1.19 0.170411 0.129521 0.92 1.53 0.188274 0.592162 Gynaecology and Obstetrics Labour and delivery complicated by umbilical cord complications (HES) T 378957 570 378531 1.28 0.249095 0.189656 0.885 1.86 0.189048 0.59299 Operations and Procedures Colposcopy biopsy (self-reported) T 378957 1641 377460 0.835 -0.18053 0.137682 0.637 1.09 0.189786 0.593239 Operations and Procedures Attention to prosthesis in organ NOC T 378957 2929 376172 1.13 0.117824 0.089848 0.943 1.34 0.189735 0.593239 Neurosciences Acute infective polyneuritisguillainbarre syndro (HES and self-reported) T 378957 290 378811 1.4 0.337535 0.257469 0.846 2.32 0.189866 0.593239 Operations and Procedures Release of entrapment of peripheral nerve at other site T 378957 778 378323 1.24 0.218322 0.166629 0.897 1.72 0.19012 0.593263 Gynaecology and Obstetrics Cervical polyps removed (self-reported) T 378957 370 378731 1.35 0.301486 0.230359 0.861 2.12 0.190613 0.593812 Operations and Procedures Plastic excision of skin of head or neck T 378957 208 378893 1.48 0.389393 0.297645 0.824 2.65 0.190789 0.593812 ENT Sinus surgery (self-reported) T 378957 1301 377800 1.19 0.170534 0.130482 0.918 1.53 0.191229 0.594414 Operations and Procedures Other diagnostic imaging of genitourinary system T 378957 209 378892 1.48 0.388667 0.297612 0.823 2.64 0.191569 0.594703 Summary HESCH Diseases of the eye and adnexa (HES) T 378957 35574 343527 1.04 0.037109 0.028493 0.981 1.1 0.192784 0.595406 Immuno-inflammation Lichen planus (HES) T 378957 501 378600 0.702 -0.35384 0.271311 0.412 1.19 0.192176 0.595406 Symptoms Voice disturbances (HES) T 378957 934 378167 0.782 -0.24618 0.18892 0.54 1.13 0.192544 0.595406 Operations and Procedures Plastic operations on cornea T 378957 258 378843 0.584 -0.53842 0.413245 0.26 1.31 0.19261 0.595406 Family history High blood pressure (family history - sibling) T 300905 61052 239977 0.97 -0.03071 0.023592 0.926 1.02 0.193063 0.595504 Operations and Procedures Diagnostic imaging of chest T 378957 2157 376944 1.15 0.135762 0.104384 0.933 1.41 0.193396 0.595768 Medication Selective calcium channel blockers with mainly vascular effects T 378957 24151 354950 0.955 -0.04555 0.035094 0.892 1.02 0.194295 0.59618 Cardiovascular Other diseases of pericardium (HES) T 378957 973 378128 0.789 -0.23707 0.182837 0.551 1.13 0.194767 0.59618 Cancer Lymphoid leukaemia (cancer register) T 378957 519 378582 0.712 -0.34007 0.262276 0.426 1.19 0.19476 0.59618 Operations and Procedures Microscopically controlled excision of lesion of skin T 378957 920 378181 1.22 0.19881 0.153216 0.903 1.65 0.194431 0.59618 Operations and Procedures Excision of other fascia T 378957 2947 376154 1.12 0.116946 0.090165 0.942 1.34 0.194626 0.59618 ENT Otitis externa (HES) T 378957 488 378613 1.31 0.266258 0.205587 0.872 1.95 0.195281 0.596695 Digestive system Embedded and impacted teeth (HES) T 378957 1708 377393 0.84 -0.17483 0.1351 0.644 1.09 0.195629 0.596695 Musculoskeletal Fibroblastic disorders (HES) T 378957 3613 375488 1.11 0.105881 0.081872 0.947 1.31 0.195926 0.596695 Genitourinary Testicular problems not cancer (HES and self-reported) T 378957 1283 377818 0.814 -0.20603 0.159266 0.596 1.11 0.195791 0.596695 Summary Maternal care related to the fetus (HES) T 378957 6059 373042 1.09 0.089652 0.069371 0.955 1.25 0.196236 0.596885 Summary Aplastic and other anaemias (HES) T 378957 11319 367782 0.937 -0.06498 0.050309 0.849 1.03 0.196508 0.596958 Digestive system Jaundice unknown cause (HES and self-reported) T 378957 1143 377958 0.806 -0.2159 0.167415 0.58 1.12 0.197195 0.598291 Gynaecology and Obstetrics Premature rupture of membranes (HES) T 378957 1011 378090 0.796 -0.22825 0.177134 0.562 1.13 0.19755 0.598614 Operations and Procedures Primary repair of inguinal hernia T 378957 13724 365377 1.06 0.057318 0.044507 0.971 1.16 0.197801 0.598621 Eye Retinal detachment (HES and self-reported) T 378957 3632 375469 1.11 0.104154 0.080971 0.947 1.3 0.198332 0.599475 Genitourinary Other disorders of prostate (HES) T 378957 1235 377866 0.815 -0.20509 0.159633 0.596 1.11 0.198887 0.599648 Operations and Procedures Procurement of drugs for chemotherapy for neoplasm in Bands 6 10 T 378957 4078 375023 1.1 0.098183 0.076404 0.95 1.28 0.198773 0.599648 Operations and Procedures Open operations on synovial membrane of joint T 378957 853 378248 0.778 -0.25141 0.195808 0.53 1.14 0.199161 0.599724 Neurosciences Dystonia (HES) T 378957 231 378870 1.44 0.366678 0.285771 0.824 2.53 0.19945 0.599844 Medication Antiinflammatory antirheumatic agents in combination T 378957 53678 325423 0.969 -0.03184 0.024868 0.923 1.02 0.200431 0.602043 Digestive system Diverticular disease of intestine (HES) T 378957 24930 354171 0.957 -0.044 0.034461 0.894 1.02 0.201644 0.602865 Medication Macrolides lincosamides and streptogramins T 378957 736 378365 0.758 -0.2765 0.216689 0.496 1.16 0.201956 0.602865 Operations and Procedures Hybrid prosthetic replacement of hip joint T 378957 286 378815 0.613 -0.48903 0.382936 0.29 1.3 0.201589 0.602865 Anthropometry Body fat percentage T 372114 NA NA NA 0.010691 0.008377 -0.00573 0.027109 0.201866 0.602865 Musculoskeletal Legs BMD bone mineral density T 4100 NA NA NA -0.11028 0.086268 -0.27936 0.058811 0.20115 0.602865 Mental health Anxietypanic attacks (HES and self-reported) T 378957 10392 368709 0.935 -0.06707 0.052599 0.844 1.04 0.202269 0.603052 Medication Antiemetics and antinauseants T 378957 234 378867 1.44 0.361756 0.285652 0.82 2.51 0.205361 0.607136 Summary Symptoms and signs involving the skin and subcutaneous tissue (HES) T 378957 6510 372591 0.919 -0.08458 0.066598 0.806 1.05 0.204077 0.607136 Infectious disease Bacterial infection of unspecified site (HES) T 378957 696 378405 1.25 0.223126 0.176163 0.885 1.77 0.205302 0.607136 Operations and Procedures Minimal access to thoracic cavity T 378957 726 378375 1.24 0.217434 0.171297 0.888 1.74 0.20432 0.607136 Operations and Procedures Local anaesthetic T 378957 23563 355538 1.04 0.043107 0.034051 0.977 1.12 0.205525 0.607136 Cardiovascular High cholesterol (HES and self-reported) T 378957 62396 316705 0.971 -0.02971 0.023461 0.927 1.02 0.205418 0.607136 Gynaecology and Obstetrics Benign breast lump (HES and self-reported) T 378957 2336 376765 0.867 -0.14313 0.113016 0.694 1.08 0.205356 0.607136 Other Age when periods started menarche T 198421 NA NA NA 0.014466 0.01143 -0.00794 0.036869 0.205655 0.607136 ENT Disorders of vestibular function (HES) T 378957 871 378230 1.22 0.200361 0.158482 0.896 1.67 0.206139 0.60782 Operations and Procedures Therapeutic endoscopic operations on cavity of other joint T 378957 583 378518 1.27 0.240993 0.190763 0.876 1.85 0.206476 0.608069 Operations and Procedures Diagnostic endoscopic examination of mediastinum T 378957 587 378514 1.27 0.239974 0.190794 0.875 1.85 0.208478 0.613216 Genitourinary Excessive frequent and irregular menstruation (HES) T 378957 11974 367127 0.939 -0.06246 0.049899 0.852 1.04 0.210683 0.618192 Digestive system Abdominal hernia (HES and self-reported) T 378957 20644 358457 1.05 0.045974 0.036725 0.974 1.13 0.210618 0.618192 Summary Infections sexual mode of transmission (HES) T 378957 253 378848 0.597 -0.51592 0.413316 0.266 1.34 0.211939 0.621121 Summary Obesity and other hyperalimentation (HES) T 378957 9921 369180 0.935 -0.06689 0.053635 0.842 1.04 0.212348 0.621189 Respiratory Pleural plaque (HES) T 378957 645 378456 1.25 0.227069 0.182124 0.878 1.79 0.212478 0.621189 Family history Stroke (family history - sibling) T 300905 9517 291512 0.933 -0.06888 0.055299 0.838 1.04 0.212945 0.621799 Cancer Mal neo bladder (cancer register) T 378957 919 378182 1.21 0.190607 0.153484 0.896 1.63 0.214286 0.624958 Operations and Procedures Appendicectomy (self-reported) T 378957 45428 333673 1.03 0.031515 0.025392 0.982 1.08 0.214561 0.625003 Medication Cardiac stimulants excl cardiac glycosides T 378957 304 378797 0.641 -0.44436 0.358494 0.318 1.29 0.215157 0.625048 Summary Symptoms circulatory and respiratory systems (HES) T 378957 45652 333449 0.968 -0.03216 0.026022 0.92 1.02 0.216562 0.625048 Musculoskeletal Other joint disorders (HES) T 378957 11928 367173 0.941 -0.06048 0.048937 0.855 1.04 0.216484 0.625048 Musculoskeletal Systemic lupus erythematosus (HES) T 378957 324 378777 1.36 0.308692 0.249493 0.835 2.22 0.215984 0.625048 Operations and Procedures Reconstruction of breast using abdominal flap T 378957 275 378826 0.623 -0.47338 0.383152 0.294 1.32 0.216652 0.625048 Operations and Procedures Injection into varicose vein of leg T 378957 823 378278 1.23 0.203299 0.164392 0.888 1.69 0.216207 0.625048 Operations and Procedures Other excision of testis T 378957 508 378593 1.29 0.254381 0.205623 0.862 1.93 0.216043 0.625048 Respiratory Pneumothorax (HES and self-reported) T 378957 906 378195 1.21 0.194233 0.156599 0.893 1.65 0.214859 0.625048 Haematology Aplastic anaemia (HES and self-reported) T 378957 429 378672 1.31 0.270422 0.219184 0.853 2.01 0.217291 0.626141 Operations and Procedures Other operations on mastoid T 378957 342 378759 1.35 0.29889 0.24242 0.838 2.17 0.217598 0.626277 Summary Congenital malformations of the circulatory system (HES) T 378957 1083 378018 1.19 0.176928 0.143746 0.9 1.58 0.218382 0.627742 Digestive system Other disorders of teeth and supporting structures (HES) T 378957 2410 376691 1.13 0.122087 0.0993 0.93 1.37 0.218889 0.627742 Operations and Procedures Manipulation of rectum T 378957 1760 377341 1.15 0.141996 0.11548 0.919 1.45 0.21884 0.627742 Respiratory Pulmonary oedema (HES) T 378957 428 378673 0.698 -0.35916 0.293056 0.393 1.24 0.220356 0.631121 Genitourinary Polyp of female genital tract (HES) T 378957 9793 369308 1.06 0.06291 0.051404 0.963 1.18 0.221015 0.631121 Operations and Procedures Pituitary surgery (self-reported) T 378957 215 378886 0.575 -0.5535 0.452583 0.237 1.4 0.221338 0.631121 Operations and Procedures Other operations on breast T 378957 910 378191 0.794 -0.23127 0.189123 0.548 1.15 0.221377 0.631121 Operations and Procedures Open drainage of peritoneum T 378957 297 378804 1.37 0.314985 0.25728 0.828 2.27 0.220843 0.631121 Medication Progestogens T 378957 2010 377091 1.14 0.131908 0.108237 0.923 1.41 0.22296 0.631144 Cardiovascular Arterial embolism and thrombosis (HES) T 378957 839 378262 0.784 -0.24372 0.199577 0.53 1.16 0.222026 0.631144 Musculoskeletal Other disorders of muscle (HES) T 378957 806 378295 0.781 -0.24763 0.203423 0.524 1.16 0.223481 0.631144 Gynaecology and Obstetrics Long labour (HES) T 378957 1773 377328 0.851 -0.16097 0.131891 0.657 1.1 0.222283 0.631144 Cancer Cin pre cancer cells cervix (self-reported) T 378957 1313 377788 0.831 -0.18529 0.152209 0.617 1.12 0.223478 0.631144 Cardiovascular Blood pressure medication T 376081 77608 298614 0.974 -0.02635 0.021636 0.934 1.02 0.223189 0.631144 Digestive system Oesophageal varicies (HES and self-reported) T 378957 501 378600 1.29 0.250797 0.205493 0.859 1.92 0.222287 0.631144 Other Other substance abusedependency (HES and self-reported) T 378957 10328 368773 0.937 -0.06456 0.053018 0.845 1.04 0.223351 0.631144 Gynaecology and Obstetrics Other disorders of amniotic fluid and membranes (HES) T 378957 236 378865 0.604 -0.5042 0.414571 0.268 1.36 0.223909 0.63135 Genitourinary Renal failure requiring dialysis (HES and self-reported) T 378957 660 378441 0.759 -0.27634 0.227301 0.486 1.18 0.224078 0.63135 Operations and Procedures Excision or biopsy of lymph node T 378957 6160 372941 0.921 -0.08282 0.068293 0.805 1.05 0.225266 0.633955 Mental health Mental and behavioural disorders due to use of tobacco (HES) T 378957 10134 368967 0.937 -0.0648 0.053495 0.844 1.04 0.225751 0.634579 Gynaecology and Obstetrics Other obstructed labour (HES) T 378957 309 378792 1.36 0.304136 0.25136 0.828 2.22 0.226292 0.635358 Neurosciences Anorexiabulimiaother eating disorder (HES and self-reported) T 378957 336 378765 1.34 0.293249 0.242737 0.833 2.16 0.227011 0.636635 Neurosciences Other extrapyramidal and movement disorders (HES) T 378957 562 378539 0.743 -0.29734 0.246484 0.458 1.2 0.227695 0.63671 Genitourinary Tubulo interstitial nephritis not specified as acute or chronic (HES) T 378957 837 378264 1.22 0.195764 0.162347 0.885 1.67 0.227882 0.63671 Metabolic Parathyroidectomy (self-reported) T 378957 531 378570 0.736 -0.30629 0.254123 0.447 1.21 0.228095 0.63671 Respiratory Asbestosis (HES and self-reported) T 378957 271 378830 0.63 -0.4623 0.38345 0.297 1.34 0.227964 0.63671 Gynaecology and Obstetrics Placental disorders (HES) T 378957 225 378876 1.41 0.345143 0.287568 0.804 2.48 0.230058 0.638396 Medication Immunosuppressants T 378957 3722 375379 1.1 0.096793 0.080816 0.94 1.29 0.231036 0.638396 Family history Prostate cancer (family history - father) T 338597 25442 313287 0.96 -0.04039 0.033765 0.899 1.03 0.231614 0.638396 Cancer Carc in situ of other sites (cancer register) T 378957 561 378540 0.744 -0.2955 0.246691 0.459 1.21 0.230979 0.638396 Operations and Procedures Other repair of bladder T 378957 216 378885 1.43 0.355896 0.297301 0.797 2.56 0.231272 0.638396 Operations and Procedures Operations on bursa T 378957 1825 377276 0.857 -0.15425 0.128556 0.666 1.1 0.230196 0.638396 Operations and Procedures Operations on sentinel lymph node T 378957 1143 377958 0.82 -0.19838 0.165421 0.593 1.13 0.23043 0.638396 Operations and Procedures Minimal access to other body cavity T 378957 8899 370202 1.07 0.064142 0.053406 0.96 1.18 0.229739 0.638396 Metabolic Insulin T 376081 3934 372288 0.902 -0.10336 0.085971 0.762 1.07 0.229255 0.638396 Digestive system Umbilical hernia (HES and self-reported) T 378957 3644 375457 0.898 -0.10713 0.089536 0.754 1.07 0.231481 0.638396 Immuno-inflammation Lichen planus (HES and self-reported) T 378957 627 378474 0.756 -0.27934 0.23321 0.479 1.19 0.230985 0.638396 Neurosciences Stomach or abdominal pain T 378087 37960 340271 1.03 0.032911 0.027555 0.979 1.09 0.232325 0.639624 Summary Other diseases of blood and blood forming organs (HES) T 378957 4191 374910 1.1 0.090819 0.076319 0.943 1.27 0.234047 0.639976 Medication Anticholinergic agents T 378957 240 378861 1.4 0.339689 0.285448 0.803 2.46 0.234039 0.639976 Gynaecology and Obstetrics Endometrial ablation (self-reported) T 378957 1925 377176 1.14 0.130822 0.109829 0.919 1.41 0.233595 0.639976 Operations and Procedures Other operations on spine T 378957 4622 374479 0.91 -0.09387 0.078881 0.78 1.06 0.234019 0.639976 Metabolic Hyperthyroidismthyrotoxicosis (HES and self-reported) T 378957 4020 375081 0.904 -0.10117 0.084885 0.765 1.07 0.233336 0.639976 Genitourinary Nephritis (HES and self-reported) T 378957 1824 377277 1.14 0.134426 0.112783 0.917 1.43 0.233301 0.639976 Medication Other sex hormones and modulators of the genital system T 378957 368 378733 1.32 0.27996 0.236129 0.833 2.1 0.235771 0.641052 Operations and Procedures Other operations on kidney T 378957 281 378820 1.37 0.315466 0.265656 0.814 2.31 0.235031 0.641052 Operations and Procedures Diagnostic endoscopic examination of peritoneum T 378957 4723 374378 0.911 -0.09366 0.078972 0.78 1.06 0.235615 0.641052 Gynaecology and Obstetrics Polycystic ovariespolycystic ovarian syndrome (HES and self-reported) T 378957 580 378521 0.752 -0.28496 0.240245 0.47 1.2 0.23558 0.641052 Gynaecology and Obstetrics Cervical problem (HES and self-reported) T 378957 6385 372716 1.08 0.074536 0.062768 0.953 1.22 0.235041 0.641052 ENT Otalgia and effusion of ear (HES) T 378957 479 378622 1.28 0.24817 0.209696 0.85 1.93 0.236623 0.642644 Respiratory Unspecified chronic bronchitis (HES) T 378957 243 378858 1.4 0.336797 0.285409 0.8 2.45 0.23798 0.644954 Musculoskeletal Bone disorder (HES and self-reported) T 378957 5041 374060 1.09 0.082728 0.070109 0.947 1.25 0.238009 0.644954 Operations and Procedures Diagnostic imaging of genitourinary system T 378957 293 378808 1.37 0.31264 0.265387 0.813 2.3 0.238775 0.646302 Musculoskeletal Fracture neck cervical fracture (HES and self-reported) T 378957 345 378756 1.33 0.285278 0.242374 0.827 2.14 0.23919 0.646699 Cardiovascular Multiple valve diseases (HES) T 378957 1492 377609 1.16 0.145317 0.123787 0.907 1.47 0.240426 0.648909 Medication Other diagnostic agents T 378957 392 378709 0.699 -0.35876 0.306035 0.383 1.27 0.241085 0.648909 Operations and Procedures Intramuscular injection T 378957 1308 377793 0.835 -0.18012 0.15364 0.618 1.13 0.24106 0.648909 Musculoskeletal Fracture sternum (HES and self-reported) T 378957 240 378861 0.616 -0.48508 0.413594 0.274 1.38 0.240864 0.648909 Respiratory FEV1 FVC ratio T 286064 NA NA NA 0.011224 0.009591 -0.00757 0.030021 0.241888 0.650344 Musculoskeletal Other joint disorder (HES and self-reported) T 378957 9807 369294 0.939 -0.06315 0.054037 0.844 1.04 0.242533 0.651351 Summary Other congenital malformations of the digestive system (HES) T 378957 632 378469 1.24 0.215383 0.184472 0.864 1.78 0.242983 0.651833 Medication Vitamin a and d incl combinations of the two T 378957 10919 368182 1.06 0.057015 0.048972 0.962 1.17 0.244328 0.653374 Musculoskeletal Paget s disease of bone (HES) T 378957 243 378858 0.618 -0.48153 0.413515 0.275 1.39 0.244227 0.653374 Eye Corneal resistance factor right T 81141 NA NA NA -0.02064 0.017731 -0.05539 0.014112 0.244371 0.653374 Other Sleep duration T 376654 NA NA NA -0.00968 0.008334 -0.02602 0.006651 0.245251 0.655 Gynaecology and Obstetrics Antepartum haemorrhage (HES) T 378957 588 378513 1.25 0.219592 0.189747 0.859 1.81 0.247156 0.658627 Operations and Procedures Other operations on anterior chamber of eye T 378957 405 378696 0.712 -0.33954 0.293301 0.401 1.27 0.247005 0.658627 Medication Antiarrhythmics class i and iii T 378957 1297 377804 0.837 -0.17741 0.153735 0.62 1.13 0.248506 0.660787 Cancer Reported occurrences of cancer T 61089 NA NA NA 0.023362 0.020245 -0.01632 0.063043 0.248515 0.660787 Respiratory Respiratory disorders in diseases classified elsewhere (HES) T 378957 201 378900 1.43 0.356859 0.310476 0.777 2.63 0.250394 0.661491 Medication Decongestants and antiallergics T 378957 420 378681 0.714 -0.33715 0.293085 0.402 1.27 0.249995 0.661491 Cancer Squamous cell carcinoma (self-reported) T 378957 470 378631 0.731 -0.31304 0.271587 0.429 1.25 0.249056 0.661491 Operations and Procedures Removal of epididymal cyst (self-reported) T 378957 269 378832 0.644 -0.44037 0.383175 0.304 1.36 0.250446 0.661491 Operations and Procedures Other replacement of aneurysmal segment of aorta T 378957 295 378806 1.34 0.295908 0.257614 0.811 2.23 0.250702 0.661491 Operations and Procedures Insertion of skin expander into subcutaneous tissue T 378957 446 378655 0.723 -0.32411 0.28179 0.416 1.26 0.250073 0.661491 Digestive system Constipation (HES and self-reported) T 378957 9731 369370 0.939 -0.06241 0.054245 0.845 1.04 0.249909 0.661491 Summary Chronic rheumatic heart diseases (HES) T 378957 1969 377132 1.13 0.124829 0.109032 0.915 1.4 0.252257 0.664139 Respiratory CopdMappingStrict T 189997 16733 173340 1.05 0.049322 0.043056 0.966 1.14 0.251997 0.664139 Operations and Procedures Removal of testicle orchidectomy (self-reported) T 378957 1211 377890 1.17 0.15854 0.138645 0.893 1.54 0.252833 0.664416 Operations and Procedures Harvest of other multiple tissue T 378957 281 378820 1.35 0.303763 0.26569 0.805 2.28 0.252914 0.664416 Digestive system Gastricstomach ulcers (HES and self-reported) T 378957 6128 372973 0.925 -0.07847 0.068863 0.808 1.06 0.25448 0.667802 Summary Disorders of optic nerve and visual pathways (HES) T 378957 383 378718 0.706 -0.34768 0.306149 0.388 1.29 0.256101 0.668418 Summary Diseases of arteries arterioles and capillaries (HES) T 378957 6751 372350 0.929 -0.07418 0.065296 0.817 1.06 0.255917 0.668418 Cancer Mal neo rectum (cancer register) T 378957 1203 377898 1.17 0.156091 0.137289 0.893 1.53 0.255557 0.668418 Operations and Procedures Local anaesthetics for ophthalmology procedures T 378957 5563 373538 1.08 0.075712 0.066616 0.947 1.23 0.255725 0.668418 Operations and Procedures Blood withdrawal T 378957 3031 376070 1.11 0.101232 0.08914 0.929 1.32 0.256102 0.668418 Genitourinary Chronic nephritic syndrome (HES) T 378957 791 378310 0.797 -0.22669 0.199772 0.539 1.18 0.256479 0.668677 Digestive system Peritonitis (HES and self-reported) T 378957 1989 377112 1.13 0.123406 0.108848 0.914 1.4 0.256901 0.669054 Summary Disorders of other endocrine glands (HES) T 378957 2354 376747 0.881 -0.12692 0.112111 0.707 1.1 0.257582 0.670103 Cardiovascular LV stroke volume T 3764 NA NA NA 0.101269 0.089531 -0.07421 0.27675 0.258009 0.670489 Infectious disease Chronic viral hepatitis (HES) T 378957 343 378758 0.683 -0.3813 0.338087 0.352 1.32 0.259398 0.672824 Cardiovascular Pacemaker insertion (self-reported) T 378957 287 378814 0.667 -0.40468 0.358868 0.33 1.35 0.259466 0.672824 Digestive system Oesophageal varices (HES) T 378957 488 378613 1.27 0.235187 0.209641 0.839 1.91 0.261923 0.676284 Operations and Procedures Pancreas surgery (self-reported) T 378957 205 378896 0.601 -0.50891 0.452836 0.247 1.46 0.261088 0.676284 Mental health Ever depressed for a whole week T 124001 66758 57306 1.03 0.032851 0.029276 0.976 1.09 0.261822 0.676284 Musculoskeletal Vasculitis (HES and self-reported) T 378957 1756 377345 1.14 0.129052 0.114947 0.908 1.43 0.261561 0.676284 Cardiovascular Heart failure (HES) T 378957 4854 374247 0.917 -0.08626 0.077071 0.789 1.07 0.263035 0.677702 Operations and Procedures Other operations on trabecular meshwork of eye T 378957 236 378865 0.629 -0.46331 0.413747 0.28 1.42 0.262802 0.677702 Summary Other congenital malformations (HES) T 378957 615 378486 1.23 0.209381 0.187468 0.854 1.78 0.264044 0.67819 Cardiovascular Varicose veins of lower extremities (HES) T 378957 9985 369116 1.06 0.056751 0.050874 0.958 1.17 0.264632 0.67819 Gynaecology and Obstetrics Myomectomy fibroids removed (self-reported) T 378957 2071 377030 1.13 0.119245 0.106761 0.914 1.39 0.264021 0.67819 Operations and Procedures Operations on omentum T 378957 1948 377153 0.871 -0.13844 0.123969 0.683 1.11 0.264121 0.67819 Operations and Procedures Other primary fusion of other joint T 378957 1462 377639 0.851 -0.16093 0.144215 0.642 1.13 0.264456 0.67819 Medication Opioids T 378957 102262 276839 1.02 0.020977 0.018818 0.984 1.06 0.264972 0.67834 Eye Diabetic eye disease (HES and self-reported) T 378957 1737 377364 0.865 -0.14555 0.130747 0.669 1.12 0.265613 0.679259 Respiratory Pneumothorax (HES) T 378957 762 378339 1.21 0.189347 0.171084 0.864 1.69 0.268402 0.682816 Gynaecology and Obstetrics Spontaneous abortion (HES) T 378957 1258 377843 0.841 -0.17352 0.157102 0.618 1.14 0.26937 0.682816 Operations and Procedures Muscle soft tissue surgery (self-reported) T 378957 10926 368175 1.06 0.053969 0.048743 0.959 1.16 0.268201 0.682816 Operations and Procedures Arteriovenous shunt T 378957 297 378804 0.673 -0.39598 0.358608 0.333 1.36 0.269504 0.682816 Cardiovascular Heart valve problemheart murmur (HES and self-reported) T 378957 7532 371569 0.934 -0.0678 0.061321 0.829 1.05 0.268894 0.682816 Cardiovascular Arterial embolism (HES and self-reported) T 378957 762 378339 0.795 -0.22943 0.207801 0.529 1.19 0.269555 0.682816 Eye Optic neuritis (HES and self-reported) T 378957 206 378895 0.606 -0.50142 0.452872 0.249 1.47 0.268212 0.682816 Musculoskeletal Fracture face orbit eye socket (HES and self-reported) T 378957 477 378624 0.741 -0.29994 0.271516 0.435 1.26 0.269291 0.682816 Other Getting up in morning T 377919 NA NA NA -0.00921 0.008331 -0.02554 0.007116 0.268797 0.682816 Operations and Procedures Other operations on blood vessel T 378957 317 378784 0.689 -0.37211 0.338425 0.355 1.34 0.27154 0.687122 Summary Urolithiasis (HES) T 378957 5984 373117 0.927 -0.07621 0.069365 0.809 1.06 0.271907 0.687328 Operations and Procedures Autonomic cardiovascular testing T 378957 235 378866 0.636 -0.4531 0.413683 0.283 1.43 0.273391 0.690355 Gynaecology and Obstetrics Mammoplasty cosmetic operation on breast (self-reported) T 378957 2699 376402 0.892 -0.11389 0.104085 0.728 1.09 0.273884 0.690876 Operations and Procedures Extirpation of lesion of conjunctiva T 378957 351 378750 0.704 -0.35045 0.321034 0.375 1.32 0.275004 0.692498 Operations and Procedures Destruction of lesion of cervix uteri T 378957 2136 376965 0.879 -0.12902 0.118212 0.697 1.11 0.275102 0.692498 Summary Coagulation defects purpura and other haemorrhagic conditions (HES) T 378957 2426 376675 1.11 0.108133 0.09929 0.917 1.35 0.276126 0.69435 Cancer Non melanoma skin cancer (self-reported) T 378957 550 378551 0.765 -0.26755 0.246623 0.472 1.24 0.277981 0.695385 Operations and Procedures Bone surgery joint surgery (self-reported) T 378957 3136 375965 0.901 -0.10438 0.096206 0.746 1.09 0.277935 0.695385 Summary Mal neo of digestive organs (cancer register) T 378957 5957 373144 1.07 0.070511 0.064848 0.945 1.22 0.276893 0.695385 Genitourinary Kidney nephropathy (HES and self-reported) T 378957 417 378684 1.28 0.243551 0.224219 0.822 1.98 0.277381 0.695385 Gynaecology and Obstetrics Dysmenorrhoea dysmenorrhea (HES and self-reported) T 378957 1606 377495 0.862 -0.14866 0.13691 0.659 1.13 0.277547 0.695385 Genitourinary Inflammatory disease of uterus except cervix (HES) T 378957 260 378841 0.66 -0.4153 0.383443 0.311 1.4 0.27877 0.696636 Operations and Procedures Sampling of lymph nodes T 378957 2952 376149 0.898 -0.1072 0.099153 0.74 1.09 0.279609 0.698008 Operations and Procedures Other cardiac pacemaker system T 378957 1141 377960 0.839 -0.17601 0.163389 0.609 1.16 0.28136 0.701652 Operations and Procedures Removal of products of delivered uterus T 378957 339 378762 0.707 -0.34687 0.322269 0.376 1.33 0.281772 0.701713 Immuno-inflammation Eczemadermatitis (HES and self-reported) T 378957 11296 367805 1.05 0.051437 0.047807 0.959 1.16 0.281967 0.701713 Summary Intestinal infectious diseases (HES) T 378957 8022 371079 1.06 0.060429 0.056433 0.951 1.19 0.284251 0.70321 Mental health Specific personality disorders (HES) T 378957 293 378808 0.681 -0.38453 0.358693 0.337 1.38 0.283702 0.70321 Symptoms Somnolence stupor and coma (HES) T 378957 636 378465 0.784 -0.24351 0.227436 0.502 1.22 0.28432 0.70321 Symptoms Enlarged lymph nodes (HES) T 378957 2200 376901 1.12 0.111622 0.104247 0.911 1.37 0.284285 0.70321 Operations and Procedures Other caesarean delivery T 378957 1946 377155 0.875 -0.13354 0.124379 0.686 1.12 0.282982 0.70321 Digestive system Inguinal hernia (HES and self-reported) T 378957 15351 363750 1.05 0.045485 0.042467 0.963 1.14 0.28413 0.70321 Mental health Happiness T 125989 NA NA NA 0.015309 0.014312 -0.01274 0.043361 0.284783 0.703633 Respiratory Pneumonia due to Streptococcus pneumoniae (HES) T 378957 234 378867 0.643 -0.44216 0.413736 0.286 1.45 0.285199 0.703939 Cardiovascular Complications and ill defined descriptions of heart disease (HES) T 378957 3773 375328 0.911 -0.09327 0.087427 0.767 1.08 0.286069 0.705135 Respiratory Asthma (HES) T 378957 23838 355263 0.964 -0.03705 0.034744 0.9 1.03 0.286269 0.705135 Operations and Procedures Operations on nipple T 378957 610 378491 0.78 -0.24818 0.233391 0.494 1.23 0.287615 0.707727 Operations and Procedures Ultrasound scan (self-reported) T 378957 230 378871 0.644 -0.43963 0.413833 0.286 1.45 0.288088 0.708167 Operations and Procedures Other operations on anterior abdominal wall T 378957 600 378501 1.22 0.202115 0.190611 0.842 1.78 0.288983 0.708199 Operations and Procedures Revisional decompression operations on lumbar spine T 378957 287 378814 0.684 -0.38046 0.358804 0.338 1.38 0.288979 0.708199 Operations and Procedures Other open operations on intra articular structure T 378957 1473 377628 0.859 -0.15149 0.142818 0.65 1.14 0.288812 0.708199 Medication Omeprazole e g Zanprol T 374624 22414 352354 0.963 -0.03809 0.036039 0.897 1.03 0.290565 0.711353 Respiratory Pneumonitis due to solids and liquids (HES) T 378957 560 378541 1.23 0.208124 0.197626 0.836 1.81 0.292286 0.71484 Operations and Procedures Other puncture of liver T 378957 403 378698 1.27 0.241532 0.22961 0.812 2 0.292834 0.715165 Cardiovascular Subarachnoid haemorrhage (HES and self-reported) T 378957 936 378165 1.18 0.164491 0.156429 0.868 1.6 0.293013 0.715165 Operations and Procedures Excision of organ NOC T 378957 1832 377269 1.13 0.119041 0.113355 0.902 1.41 0.293641 0.715383 Respiratory Chronic obstructive airways diseasecopd (HES and self-reported) T 378957 8796 370305 1.06 0.057312 0.054581 0.952 1.18 0.293696 0.715383 Summary Acute upper respiratory infections (HES) T 378957 2654 376447 0.895 -0.1105 0.105387 0.728 1.1 0.2944 0.71565 Operations and Procedures Other operations on tonsil T 378957 503 378598 0.76 -0.27506 0.26231 0.454 1.27 0.294357 0.71565 Genitourinary Pyelonephritis (HES and self-reported) T 378957 1141 377960 1.16 0.14879 0.14228 0.878 1.53 0.295675 0.718025 Musculoskeletal Scoliosis (HES and self-reported) T 378957 1135 377966 0.843 -0.1706 0.163306 0.612 1.16 0.296169 0.718501 Respiratory Pleural plaques not known asbestosis (HES and self-reported) T 378957 690 378411 1.21 0.187007 0.179189 0.849 1.71 0.296658 0.718963 Operations and Procedures Dilation of organ NOC T 378957 512 378589 0.767 -0.26495 0.254186 0.466 1.26 0.297257 0.719691 Summary Other soft tissue disorders (HES) T 378957 25100 354001 1.04 0.034416 0.033057 0.97 1.1 0.297834 0.720364 Operations and Procedures Other leg region T 378957 287 378814 0.689 -0.37313 0.358797 0.341 1.39 0.298363 0.720919 Operations and Procedures Operations on urethral orifice T 378957 464 378637 0.754 -0.28223 0.271674 0.443 1.28 0.298873 0.721428 Respiratory Pleural effusion (HES) T 378957 4725 374376 1.08 0.075045 0.072419 0.935 1.24 0.300079 0.723614 Summary Schizophrenia schizotypal and delusional disorders (HES) T 378957 899 378202 0.823 -0.19514 0.189029 0.568 1.19 0.301919 0.723782 Infectious disease Bacterial agents as the cause of diseases (HES) T 378957 7935 371166 1.06 0.058725 0.056899 0.949 1.19 0.302028 0.723782 Neurosciences Epilepsy (HES) T 378957 3387 375714 1.09 0.08803 0.085332 0.924 1.29 0.302252 0.723782 Operations and Procedures Knee surgery not replacement (self-reported) T 378957 12555 366546 0.952 -0.04944 0.04776 0.867 1.05 0.300549 0.723782 ENT Rhinoplasty nose surgery (self-reported) T 378957 2193 376908 0.887 -0.11947 0.115692 0.707 1.11 0.301748 0.723782 Operations and Procedures Other excision of right hemicolon T 378957 1421 377680 0.86 -0.1504 0.145728 0.647 1.14 0.302037 0.723782 Operations and Procedures Attention to skin expander in subcutaneous tissue T 378957 431 378670 0.748 -0.29089 0.281935 0.43 1.3 0.302192 0.723782 Respiratory Pyothorax (HES) T 378957 288 378813 1.31 0.273698 0.26551 0.781 2.21 0.302616 0.723934 ENT Thyroiditis (HES and self-reported) T 378957 442 378659 1.25 0.225591 0.219035 0.816 1.92 0.303043 0.724237 Infectious disease Herpesviral (HES) T 378957 232 378869 0.654 -0.42414 0.413783 0.291 1.47 0.305352 0.729032 Operations and Procedures Excision of lung T 378957 810 378291 1.19 0.170411 0.166528 0.856 1.64 0.30616 0.729644 Operations and Procedures Other operations on delivered uterus T 378957 225 378876 1.36 0.305004 0.298175 0.756 2.43 0.306354 0.729644 Operations and Procedures Therapeutic endoscopic operations on cavity of knee joint T 378957 4112 374989 0.919 -0.085 0.083122 0.78 1.08 0.306517 0.729644 Medication Antipsychotics T 378957 2920 376181 0.903 -0.10181 0.099767 0.743 1.1 0.30748 0.730951 Operations and Procedures Extirpation of lesion of vagina T 378957 675 378426 0.801 -0.22149 0.217123 0.524 1.23 0.307673 0.730951 Eye Eye surgery (self-reported) T 378957 3495 375606 0.912 -0.09246 0.090817 0.763 1.09 0.308657 0.732495 Operations and Procedures Removal of repair material from skin T 378957 460 378641 0.759 -0.27616 0.271585 0.446 1.29 0.309235 0.732495 Medication Folic acid or Folate Vit B9 T 376892 8174 368862 0.942 -0.05997 0.058953 0.839 1.06 0.309036 0.732495 Operations and Procedures Other operations on eyelid T 378957 931 378170 0.831 -0.18565 0.182953 0.58 1.19 0.310227 0.734123 Digestive system Gastroenteritisdysentry (HES and self-reported) T 378957 8121 370980 1.06 0.056788 0.056183 0.948 1.18 0.312123 0.737885 Digestive system Fissure and fistula of anal and rectal regions (HES) T 378957 2863 376238 1.1 0.093474 0.092612 0.916 1.32 0.312828 0.738559 Operations and Procedures Therapeutic spinal puncture T 378957 253 378848 1.33 0.287431 0.285 0.762 2.33 0.313201 0.738559 Digestive system Gastrooesophageal reflux gord gastric reflux (HES and self-reported) T 378957 32601 346500 0.97 -0.03041 0.030157 0.914 1.03 0.313328 0.738559 Medication Drugs for functional gastrointestinal disorders T 378957 3769 375332 1.08 0.081423 0.080861 0.926 1.27 0.313961 0.738606 Gynaecology and Obstetrics Menorrhagia unknown cause (HES and self-reported) T 378957 12816 366285 0.953 -0.04832 0.047968 0.867 1.05 0.313728 0.738606 Neurosciences Sleep disorders (HES) T 378957 4841 374260 0.926 -0.07724 0.076981 0.796 1.08 0.315663 0.738794 Cardiovascular Rheumatic mitral valve diseases (HES) T 378957 286 378815 0.698 -0.36012 0.35885 0.345 1.41 0.315606 0.738794 Symptoms Other symptoms and signs involving the digestive system and abdomen (HES) T 378957 13806 365295 1.04 0.043739 0.043669 0.959 1.14 0.316535 0.738794 Eye Cataract extraction lens implant (self-reported) T 378957 4095 375006 1.08 0.077286 0.07732 0.928 1.26 0.317528 0.738794 Operations and Procedures Splenectomy (self-reported) T 378957 791 378310 0.818 -0.20054 0.199661 0.553 1.21 0.315177 0.738794 Operations and Procedures Rectal sigmoid resection (self-reported) T 378957 534 378567 1.22 0.20195 0.20138 0.825 1.82 0.315941 0.738794 Operations and Procedures Spinal cord surgery (self-reported) T 378957 508 378593 0.775 -0.2546 0.254222 0.471 1.28 0.316599 0.738794 Neurosciences Facial pains for 3 months vs no pain T 368534 3287 365389 1.09 0.086533 0.086604 0.92 1.29 0.317707 0.738794 Operations and Procedures Intrauterine contraceptive device T 378957 5122 373979 0.928 -0.07504 0.075149 0.801 1.07 0.318025 0.738794 Operations and Procedures Diagnostic imaging of pelvis T 378957 1273 377828 1.14 0.134748 0.134736 0.879 1.49 0.317268 0.738794 Operations and Procedures Chemical destruction of lesion of organ NOC T 378957 228 378873 0.66 -0.41584 0.413969 0.293 1.49 0.315129 0.738794 Respiratory Pleural effusion (HES and self-reported) T 378957 4887 374214 1.07 0.071698 0.071386 0.934 1.24 0.3152 0.738794 Mental health Insomnia (HES and self-reported) T 378957 5225 373876 0.929 -0.07385 0.073958 0.803 1.07 0.318028 0.738794 Symptoms Other symptoms and signs involving the urinary system (HES) T 378957 4602 374499 1.08 0.073342 0.07368 0.931 1.24 0.319535 0.740866 Symptoms Abnormal findings on diagnostic imaging of other body structures (HES) T 378957 2807 376294 0.904 -0.10086 0.101287 0.741 1.1 0.319334 0.740866 Family history Severe depression (family history - mother) T 354043 23297 330884 1.03 0.033985 0.034205 0.967 1.11 0.320426 0.742218 Gynaecology and Obstetrics Perineal laceration during delivery (HES) T 378957 4945 374156 1.08 0.075045 0.075706 0.929 1.25 0.321552 0.743396 Operations and Procedures Stabilisation of spine T 378957 284 378817 1.3 0.263311 0.265564 0.773 2.19 0.321433 0.743396 Medication Antiglaucoma preparations and miotics T 378957 4850 374251 0.927 -0.07543 0.076206 0.799 1.08 0.322235 0.744261 Operations and Procedures Late operations NOC T 378957 5407 373694 1.07 0.067146 0.067951 0.936 1.22 0.323073 0.745482 Cancer Carc in situ of cervix (cancer register) T 378957 2991 376110 0.907 -0.09708 0.098486 0.748 1.1 0.32429 0.747574 Operations and Procedures Rehabilitation for neurological disorders T 378957 314 378787 1.29 0.252392 0.256879 0.778 2.13 0.325836 0.75042 Musculoskeletal Other disorders of cartilage (HES) T 378957 677 378424 1.19 0.177901 0.181376 0.837 1.7 0.32667 0.750905 Cardiovascular Stroke (HES and self-reported) T 378957 8571 370530 0.945 -0.05645 0.057533 0.844 1.06 0.326481 0.750905 Operations and Procedures Therapeutic endoscopic operations on urethra T 378957 2234 376867 1.11 0.101527 0.103712 0.903 1.36 0.327614 0.751681 Summary Number of treatments medications taken T 378896 NA NA NA -0.00814 0.008313 -0.02443 0.008156 0.327632 0.751681 Summary Disorders of vitreous body and globe (HES) T 378957 1565 377536 1.13 0.117966 0.121105 0.887 1.43 0.330018 0.755305 Operations and Procedures Ct scan (self-reported) T 378957 307 378794 0.719 -0.32977 0.338535 0.37 1.4 0.33 0.755305 Gynaecology and Obstetrics Miscarriage (HES and self-reported) T 378957 1976 377125 0.888 -0.11878 0.121978 0.699 1.13 0.330152 0.755305 Summary Infectious arthropathies (HES) T 378957 428 378673 1.24 0.217938 0.224061 0.802 1.93 0.330715 0.755875 Summary General symptoms and signs (HES) T 378957 41556 337545 0.974 -0.02617 0.02694 0.924 1.03 0.331371 0.756657 Digestive system Other diseases of jaws (HES) T 378957 301 378800 1.29 0.257174 0.265152 0.769 2.17 0.33209 0.757551 Operations and Procedures Abdominal pelvic adhesion surgery (self-reported) T 378957 1192 377909 1.14 0.135277 0.139631 0.871 1.51 0.332633 0.757551 Musculoskeletal Myositismyopathy (HES and self-reported) T 378957 338 378763 0.733 -0.31115 0.321207 0.39 1.37 0.332706 0.757551 Operations and Procedures Inguinal femoral hernia repair (self-reported) T 378957 12611 366490 1.05 0.044741 0.046243 0.955 1.14 0.333285 0.758153 Gynaecology and Obstetrics Breast cyst abscess removal (self-reported) T 378957 3620 375481 1.08 0.080134 0.082931 0.921 1.27 0.333904 0.758844 ENT Other diseases of inner ear (HES) T 378957 734 378367 0.818 -0.20063 0.207779 0.545 1.23 0.334245 0.758903 Operations and Procedures Primary repair of tendon T 378957 2574 376527 0.902 -0.10286 0.106612 0.732 1.11 0.334654 0.759116 Operations and Procedures Fusion of joint of toe T 378957 3193 375908 0.913 -0.09138 0.094784 0.758 1.1 0.334986 0.759155 ENT Labyrinthitis (HES and self-reported) T 378957 839 378262 0.831 -0.18517 0.192463 0.57 1.21 0.33599 0.760714 Medication Other systemic drugs for obstructive airway diseases T 378957 21417 357684 1.03 0.0342 0.035574 0.965 1.11 0.33636 0.760837 Operations and Procedures Other diagnostic tests T 378957 994 378107 0.845 -0.16792 0.174826 0.6 1.19 0.336819 0.76116 Operations and Procedures Excision of ganglion T 378957 2429 376672 1.1 0.095975 0.100186 0.904 1.34 0.33808 0.762579 Musculoskeletal Osteomyelitis (HES and self-reported) T 378957 1062 378039 0.85 -0.16279 0.169851 0.609 1.19 0.337844 0.762579 Genitourinary Other noninflammatory disorders of vagina (HES) T 378957 1392 377709 0.87 -0.13947 0.145937 0.653 1.16 0.339229 0.763628 Operations and Procedures Exploration of vagina T 378957 1868 377233 0.887 -0.11946 0.125067 0.694 1.13 0.339496 0.763628 Neurosciences Multiple sclerosis (HES and self-reported) T 378957 1635 377466 1.12 0.114791 0.120128 0.886 1.42 0.339287 0.763628 Musculoskeletal Acquired deformities of musculoskeletal (HES) T 378957 329 378772 1.28 0.244685 0.256602 0.772 2.11 0.340306 0.763947 Operations and Procedures Fixation of mandible T 378957 258 378843 0.694 -0.36571 0.383372 0.327 1.47 0.340118 0.763947 Neurosciences Paraplegia (HES and self-reported) T 378957 312 378789 0.724 -0.32254 0.338448 0.373 1.41 0.340589 0.763947 Operations and Procedures Excision of haemorrhoid T 378957 2721 376380 1.09 0.09036 0.094932 0.909 1.32 0.341175 0.764549 Digestive system Diseases of tongue (HES) T 378957 1106 377995 1.15 0.137649 0.145035 0.864 1.52 0.342582 0.766277 Gynaecology and Obstetrics Cervical polyps (HES and self-reported) T 378957 3066 376035 1.09 0.08488 0.089424 0.914 1.3 0.342525 0.766277 Medication Low ceiling diuretics thiazides T 378957 23557 355544 0.967 -0.03333 0.035192 0.903 1.04 0.343648 0.76684 Medication Anti acne preparations for topical use T 378957 1608 377493 0.879 -0.12898 0.136324 0.673 1.15 0.344073 0.76684 Operations and Procedures Lung removal pneumonectomy lobectomy (self-reported) T 378957 614 378487 1.2 0.180299 0.190575 0.824 1.74 0.344107 0.76684 Operations and Procedures Biopsy (self-reported) T 378957 275 378826 0.712 -0.3397 0.358997 0.352 1.44 0.344016 0.76684 Musculoskeletal Arthrosis of first carpometacarpal joint (HES) T 378957 1179 377922 0.86 -0.15063 0.159338 0.629 1.18 0.344481 0.766964 Cardiovascular Other acute ischaemic heart diseases (HES) T 378957 1278 377823 1.14 0.128358 0.13602 0.871 1.48 0.345339 0.768164 Operations and Procedures Reconstruction of nipple and areola T 378957 637 378464 0.811 -0.20937 0.222271 0.525 1.25 0.346217 0.769407 Medication Drugs for constipation T 378957 6110 372991 0.938 -0.06351 0.06804 0.821 1.07 0.350581 0.770323 Mental health Reaction to severe stress and adjustment disorders (HES) T 378957 481 378620 0.783 -0.24407 0.26256 0.468 1.31 0.352597 0.770323 Respiratory Chronic diseases of tonsils and adenoids (HES) T 378957 904 378197 0.84 -0.17411 0.185996 0.584 1.21 0.349237 0.770323 Digestive system Vascular disorders of intestine (HES) T 378957 936 378165 0.845 -0.16837 0.180188 0.594 1.2 0.350089 0.770323 Digestive system Other inflammatory liver diseases (HES) T 378957 623 378478 0.809 -0.21181 0.227508 0.518 1.26 0.351847 0.770323 Immuno-inflammation Other epidermal thickening (HES) T 378957 608 378493 1.19 0.177149 0.190582 0.822 1.73 0.352623 0.770323 Musculoskeletal Shoulder lesions (HES) T 378957 8336 370765 1.05 0.051621 0.05538 0.945 1.17 0.351273 0.770323 Gynaecology and Obstetrics False labour (HES) T 378957 973 378128 1.15 0.143961 0.154015 0.854 1.56 0.349933 0.770323 Cancer Basal cell carcinoma (self-reported) T 378957 3552 375549 1.08 0.077179 0.082933 0.918 1.27 0.352048 0.770323 Family history Stroke (family history - mother) T 357389 49690 307839 0.977 -0.02337 0.025064 0.93 1.03 0.351118 0.770323 Other Wheeze or whistling in the chest in last year T 371840 77179 294800 0.981 -0.01961 0.020922 0.941 1.02 0.348591 0.770323 Operations and Procedures Other adjustment to muscle of eye T 378957 211 378890 1.34 0.289903 0.309934 0.728 2.45 0.349598 0.770323 Operations and Procedures Total excision of bladder T 378957 315 378786 1.27 0.241167 0.256971 0.769 2.11 0.347988 0.770323 Operations and Procedures Introduction of substance into skin T 378957 217 378884 0.679 -0.38665 0.41416 0.302 1.53 0.350523 0.770323 Operations and Procedures Excision of muscle T 378957 476 378625 0.783 -0.24419 0.262544 0.468 1.31 0.352325 0.770323 Medication Multivitamins minerals T 376892 81736 295300 0.981 -0.01895 0.020391 0.943 1.02 0.352705 0.770323 ENT Chronic laryngitis (HES and self-reported) T 378957 1014 378087 0.85 -0.16283 0.174758 0.603 1.2 0.351485 0.770323 Anthropometry Total tissue fat percentage T 4100 NA NA NA 0.080301 0.086035 -0.08833 0.248929 0.350639 0.770323 Biological assays Haemoglobin concentration T 367722 NA NA NA 0.007927 0.008438 -0.00861 0.024465 0.347518 0.770323 Cardiovascular Congenital malformations of cardiac septa (HES) T 378957 521 378580 1.21 0.190591 0.205245 0.809 1.81 0.353094 0.770474 Haematology Other disorders of white blood cells (HES) T 378957 309 378792 0.731 -0.31361 0.338494 0.376 1.42 0.354198 0.770789 Musculoskeletal Enthesopathies of lower limb excluding foot (HES) T 378957 393 378708 0.762 -0.27198 0.293381 0.429 1.35 0.353893 0.770789 Operations and Procedures Stomach surgery (self-reported) T 378957 2197 376904 0.898 -0.10794 0.116392 0.715 1.13 0.353738 0.770789 Digestive system Sclerosing cholangitis (HES and self-reported) T 378957 454 378647 1.22 0.202254 0.218872 0.797 1.88 0.355447 0.772112 ENT Tonsiltis (HES and self-reported) T 378957 3534 375567 0.921 -0.08271 0.089477 0.773 1.1 0.355303 0.772112 Metabolic Other nontoxic goitre (HES) T 378957 1508 377593 0.879 -0.12941 0.140227 0.667 1.16 0.356071 0.77277 Mental health Other mental disorders due to brain damage (HES) T 378957 212 378889 1.33 0.284753 0.309935 0.724 2.44 0.358226 0.775147 Symptoms Unspecified urinary incontinence (HES) T 378957 2162 376939 1.1 0.097315 0.105896 0.896 1.36 0.358113 0.775147 Operations and Procedures Other operations on palate T 378957 1051 378050 0.854 -0.15829 0.172229 0.609 1.2 0.358064 0.775147 Musculoskeletal Fracture shoulder scapula (HES and self-reported) T 378957 2722 376379 0.91 -0.09484 0.103273 0.743 1.11 0.358453 0.775147 Digestive system Inguinal hernia (HES) T 378957 14392 364709 1.04 0.040212 0.043831 0.955 1.13 0.358908 0.775434 Operations and Procedures Vaginal operations to support outlet of female bladder T 378957 3234 375867 0.917 -0.0863 0.094129 0.763 1.1 0.35924 0.775456 Operations and Procedures Other total prosthetic replacement of knee joint T 378957 844 378257 0.841 -0.17334 0.189325 0.58 1.22 0.359895 0.776175 Cardiovascular Other conduction disorders (HES) T 378957 1981 377120 0.896 -0.11011 0.120534 0.707 1.13 0.360989 0.777838 Medication Low ceiling diuretics excl thiazides T 378957 1449 377652 1.12 0.114893 0.126452 0.876 1.44 0.363569 0.77877 Neurosciences Transient cerebral ischaemic attacks and related syndromes (HES) T 378957 2348 376753 1.1 0.092282 0.101804 0.898 1.34 0.364689 0.77877 Cardiovascular Other pulmonary heart diseases (HES) T 378957 745 378356 1.17 0.157586 0.173533 0.833 1.64 0.363823 0.77877 Digestive system Other diseases of gallbladder (HES) T 378957 1619 377482 1.12 0.109754 0.120937 0.88 1.41 0.364125 0.77877 Musculoskeletal Ankylosing spondylitis (HES) T 378957 573 378528 1.2 0.178265 0.197443 0.812 1.76 0.366594 0.77877 Symptoms Flatulence and related conditions (HES) T 378957 1544 377557 0.882 -0.12541 0.138834 0.672 1.16 0.366382 0.77877 Cancer Rodent ulcer (self-reported) T 378957 540 378561 1.2 0.183215 0.201367 0.809 1.78 0.362898 0.77877 Operations and Procedures Incision of breast T 378957 615 378486 0.814 -0.20592 0.227665 0.521 1.27 0.365728 0.77877 Operations and Procedures Operations on turbinate of nose T 378957 2985 376116 1.09 0.082769 0.091485 0.908 1.3 0.365609 0.77877 Operations and Procedures Repair of vault of vagina T 378957 1152 377949 1.14 0.129768 0.142568 0.861 1.51 0.362705 0.77877 Operations and Procedures Other operations on soft tissue T 378957 1277 377824 1.13 0.122782 0.135825 0.866 1.48 0.36601 0.77877 Respiratory Bronchiectasis (HES and self-reported) T 378957 2109 376992 0.899 -0.10602 0.117298 0.715 1.13 0.366082 0.77877 Digestive system Peptic ulcer (HES and self-reported) T 378957 770 378331 0.832 -0.18407 0.20363 0.558 1.24 0.366016 0.77877 Digestive system Crohns disease (HES and self-reported) T 378957 1818 377283 1.11 0.103788 0.114695 0.886 1.39 0.365517 0.77877 Musculoskeletal Fracture pelvis lower limb (HES and self-reported) T 378957 8374 370727 1.05 0.050355 0.055378 0.943 1.17 0.363196 0.77877 Biological assays Platelet distribution width T 367716 NA NA NA 0.007636 0.00844 -0.00891 0.024177 0.365596 0.77877 ENT Nonsuppurative otitis media (HES) T 378957 959 378142 0.853 -0.15928 0.177414 0.602 1.21 0.369307 0.779449 Cardiovascular Other venous embolism and thrombosis (HES) T 378957 367 378734 1.24 0.216233 0.241947 0.773 1.99 0.37147 0.779449 ENT Acute tonsillitis (HES) T 378957 512 378589 0.796 -0.22765 0.254318 0.484 1.31 0.370722 0.779449 Immuno-inflammation Other local infections of skin and subcutaneous tissue (HES) T 378957 1106 377995 0.862 -0.14839 0.165363 0.623 1.19 0.369533 0.779449 Immuno-inflammation Other disorders of pigmentation (HES) T 378957 706 378395 1.17 0.159824 0.178579 0.827 1.67 0.370801 0.779449 Musculoskeletal Other deforming dorsopathies (HES) T 378957 1558 377543 0.885 -0.12207 0.13645 0.677 1.16 0.370983 0.779449 Gynaecology and Obstetrics Prolonged pregnancy (HES) T 378957 1102 377999 1.14 0.130477 0.14626 0.855 1.52 0.372344 0.779449 Medication Hormones and related agents T 378957 756 378345 1.17 0.154974 0.173394 0.831 1.64 0.371445 0.779449 Operations and Procedures Bone scan (self-reported) T 378957 213 378888 0.688 -0.37344 0.414403 0.306 1.55 0.367503 0.779449 Cancer Multiple myeloma (cancer register) T 378957 459 378642 1.22 0.195416 0.218821 0.792 1.87 0.371836 0.779449 Operations and Procedures Other operations on lung T 378957 801 378300 0.839 -0.17497 0.19608 0.572 1.23 0.372211 0.779449 Operations and Procedures Other operations on perianal region T 378957 1153 377948 1.14 0.128406 0.143574 0.858 1.51 0.371135 0.779449 Operations and Procedures Other operations on uterus T 378957 1103 377998 0.864 -0.14584 0.163503 0.627 1.19 0.372414 0.779449 Operations and Procedures Other repair of organ NOC T 378957 893 378208 1.15 0.142966 0.160186 0.843 1.58 0.372124 0.779449 Respiratory Interstitial lung disease (HES and self-reported) T 378957 1083 378018 1.14 0.131277 0.14665 0.855 1.52 0.370694 0.779449 Neurosciences Epilepsy (HES and self-reported) T 378957 4619 374482 1.07 0.065961 0.073862 0.924 1.23 0.371839 0.779449 Musculoskeletal Gout (HES and self-reported) T 378957 6858 372243 0.944 -0.05803 0.064662 0.831 1.07 0.36946 0.779449 Musculoskeletal Other disorders of bone (HES) T 378957 1394 377707 0.878 -0.1298 0.145728 0.66 1.17 0.373109 0.780225 Metabolic Other disorders of fluid electrolyte and acid base balance (HES) T 378957 4789 374312 0.934 -0.06828 0.076817 0.803 1.09 0.374096 0.780489 Genitourinary Diseases of Bartholin s gland (HES) T 378957 665 378436 1.18 0.164031 0.184453 0.821 1.69 0.37385 0.780489 Cardiovascular LV end diastolic volume T 3764 NA NA NA 0.079657 0.089641 -0.09604 0.255353 0.374207 0.780489 Medication Vitamin b1 plain and in combination with vitamin b6 and b12 T 378957 3169 375932 0.918 -0.08504 0.095819 0.761 1.11 0.374823 0.781097 Summary Diseases of middle ear and mastoid (HES) T 378957 2903 376198 1.08 0.080721 0.092203 0.905 1.3 0.381316 0.78129 Cardiovascular Other disorders of veins (HES) T 378957 415 378686 0.781 -0.24763 0.282045 0.449 1.36 0.379955 0.78129 Respiratory Pleural effusion in conditions classified elsewhere (HES) T 378957 225 378876 0.694 -0.36572 0.414153 0.308 1.56 0.377202 0.78129 Symptoms Senility (HES) T 378957 414 378687 0.781 -0.24677 0.282107 0.449 1.36 0.381726 0.78129 Medication Antimetabolites T 378957 2405 376696 1.09 0.088433 0.100677 0.897 1.33 0.379735 0.78129 Cardiovascular Heart surgery (self-reported) T 378957 749 378352 0.837 -0.17842 0.203663 0.561 1.25 0.380994 0.78129 Operations and Procedures Large bowel resection colostomy (self-reported) T 378957 1039 378062 1.14 0.131162 0.14962 0.85 1.53 0.380683 0.78129 Operations and Procedures Testicular hydrocoele surgery drainage (self-reported) T 378957 1140 377961 1.14 0.127053 0.143878 0.856 1.51 0.377201 0.78129 Operations and Procedures Upper limb surgery (self-reported) T 378957 2145 376956 1.1 0.093817 0.10697 0.891 1.35 0.380467 0.78129 Gynaecology and Obstetrics Mastoidectomy mastoid surgery (self-reported) T 378957 700 378401 1.17 0.157567 0.178658 0.825 1.66 0.377803 0.78129 Operations and Procedures Incision of eyelid T 378957 241 378860 1.3 0.260078 0.296412 0.726 2.32 0.380258 0.78129 Operations and Procedures Excision of sigmoid colon T 378957 638 378463 0.822 -0.19653 0.222149 0.532 1.27 0.376327 0.78129 Operations and Procedures Other operations on bladder T 378957 1638 377463 1.11 0.105353 0.120183 0.878 1.41 0.3807 0.78129 Operations and Procedures Debridement and irrigation of joint T 378957 1526 377575 0.885 -0.12218 0.138865 0.674 1.16 0.378924 0.78129 Medication Aspirin T 374624 52613 322155 0.978 -0.02187 0.024968 0.932 1.03 0.381177 0.78129 Mental health Schizophrenia (HES and self-reported) T 378957 686 378415 1.17 0.161122 0.184126 0.819 1.69 0.38154 0.78129 Respiratory Empyema (HES and self-reported) T 378957 299 378802 1.26 0.232536 0.265236 0.75 2.12 0.380642 0.78129 Mental health Postnatal depression (HES and self-reported) T 378957 311 378790 1.26 0.227559 0.257128 0.759 2.08 0.376155 0.78129 Musculoskeletal Other fractures (HES and self-reported) T 378957 5304 373797 1.06 0.060394 0.069001 0.928 1.22 0.381431 0.78129 Musculoskeletal L1 L4 BMD bone mineral density T 4083 NA NA NA -0.0763 0.086284 -0.24541 0.09282 0.376562 0.78129 Family history Mother s age at death T 222989 NA NA NA 0.009536 0.010759 -0.01155 0.030623 0.375435 0.78129 Musculoskeletal Musclesoft tissue problem (HES and self-reported) T 378957 32458 346643 1.03 0.025706 0.029489 0.968 1.09 0.38336 0.783968 Medication Other cardiac preparations T 378957 50254 328847 1.02 0.021302 0.024547 0.974 1.07 0.385497 0.787002 NA Intracerebral haemorrhage T 378957 792 378309 0.843 -0.17021 0.196112 0.574 1.24 0.385447 0.787002 Digestive system Rectal prolapse (HES and self-reported) T 378957 1030 378071 1.14 0.129783 0.149702 0.849 1.53 0.385975 0.787311 Gynaecology and Obstetrics Unilateral oophorectomy (self-reported) T 378957 2254 376847 1.09 0.08998 0.103952 0.892 1.34 0.386715 0.787855 Operations and Procedures Fixation of rectum for prolapse T 378957 293 378808 0.746 -0.29319 0.338842 0.384 1.45 0.386896 0.787855 Symptoms Haemorrhage from respiratory passages (HES) T 378957 4000 375101 1.07 0.068452 0.079209 0.917 1.25 0.387478 0.788374 Operations and Procedures Diagnostic imaging of digestive tract T 378957 243 378858 0.718 -0.33134 0.383697 0.338 1.52 0.387835 0.788434 Summary HESCH Diseases of the skin and subcutaneous tissue (HES) T 378957 37154 341947 1.02 0.023919 0.027826 0.97 1.08 0.390017 0.791503 Operations and Procedures Other repair of prolapse of vagina T 378957 7298 371803 1.05 0.051352 0.059719 0.936 1.18 0.389845 0.791503 Operations and Procedures Other operations on fallopian tube T 378957 950 378151 0.856 -0.15598 0.181581 0.599 1.22 0.39033 0.791503 Summary Behav syn assoc with phys disturb and phys fact (HES) T 378957 424 378677 1.22 0.19517 0.229356 0.775 1.91 0.394798 0.795294 Digestive system Umbilical hernia (HES) T 378957 3437 375664 0.926 -0.07706 0.090975 0.775 1.11 0.39699 0.795294 Musculoskeletal Scoliosis (HES) T 378957 942 378159 0.86 -0.15074 0.177552 0.607 1.22 0.395887 0.795294 Genitourinary Hydrocele and spermatocele (HES) T 378957 1221 377880 1.13 0.11889 0.139844 0.856 1.48 0.395234 0.795294 Gynaecology and Obstetrics Unspecified maternal hypertension (HES) T 378957 540 378561 1.19 0.171951 0.20308 0.798 1.77 0.397152 0.795294 Medication Antiepileptics T 378957 6896 372205 0.947 -0.05412 0.063918 0.836 1.07 0.397113 0.795294 Cancer Car in situ other genital (cancer register) T 378957 466 378635 0.8 -0.22315 0.262736 0.478 1.34 0.395696 0.795294 Operations and Procedures Other therapeutic operations on oesophagus T 378957 331 378770 1.24 0.218118 0.256561 0.752 2.06 0.395236 0.795294 Operations and Procedures Catheterisation of heart T 378957 776 378325 1.16 0.146051 0.171056 0.828 1.62 0.393207 0.795294 Operations and Procedures Primary excision of cervical intervertebral disc T 378957 805 378296 0.846 -0.16707 0.196002 0.576 1.24 0.393999 0.795294 Gynaecology and Obstetrics Uterine polyps (HES and self-reported) T 378957 8016 371085 1.05 0.048175 0.056808 0.939 1.17 0.396423 0.795294 ENT Vocal cord polyp (HES and self-reported) T 378957 392 378709 0.779 -0.24913 0.293404 0.439 1.39 0.395826 0.795294 Cardiovascular Pericarditis (HES and self-reported) T 378957 1193 377908 0.875 -0.13371 0.157431 0.643 1.19 0.395703 0.795294 Immuno-inflammation Allergy to house dust mite (HES and self-reported) T 378957 279 378822 1.26 0.232416 0.274489 0.737 2.16 0.397149 0.795294 Cardiovascular QRS duration T 8938 NA NA NA 0.048524 0.057018 -0.06323 0.160279 0.394755 0.795294 Medication Antivertigo preparations T 378957 1504 377597 1.11 0.106708 0.126288 0.869 1.43 0.398131 0.796593 Gynaecology and Obstetrics Ectopic pregnancy (HES) T 378957 264 378837 0.739 -0.30242 0.360181 0.365 1.5 0.401109 0.797912 Symptoms Cardiac murmurs and other cardiac sounds (HES) T 378957 965 378136 1.14 0.130078 0.154641 0.841 1.54 0.400257 0.797912 Operations and Procedures Other operations on retina T 378957 498 378603 0.807 -0.21418 0.254384 0.49 1.33 0.399819 0.797912 Operations and Procedures Therapeutic transluminal operations on heart T 378957 862 378239 0.855 -0.15647 0.186172 0.594 1.23 0.40066 0.797912 Operations and Procedures Repair of recurrent inguinal hernia T 378957 1175 377926 1.13 0.118965 0.141286 0.854 1.49 0.39978 0.797912 Digestive system Inflammatory bowel disease (HES and self-reported) T 378957 4246 374855 1.07 0.064541 0.076864 0.917 1.24 0.401084 0.797912 Musculoskeletal Spine BMD bone mineral density T 4100 NA NA NA -0.07259 0.0863 -0.24174 0.096561 0.400293 0.797912 Symptoms Unspecified haematuria (HES) T 378957 14238 364863 1.04 0.036207 0.043183 0.953 1.13 0.401774 0.798576 Digestive system Crohn s disease (HES) T 378957 1547 377554 1.11 0.104036 0.124351 0.87 1.42 0.402797 0.79929 Operations and Procedures Examination of organ NOC T 378957 581 378520 1.18 0.165214 0.197353 0.801 1.74 0.402507 0.79929 Medication Vasodilators used in cardiac diseases T 378957 5385 373716 0.941 -0.06079 0.072844 0.816 1.09 0.404009 0.800376 Operations and Procedures Soft tissue operations on joint of toe T 378957 2721 376380 0.918 -0.08558 0.102494 0.751 1.12 0.403718 0.800376 Summary Disorders of skin appendages (HES) T 378957 9390 369711 1.04 0.04392 0.052751 0.942 1.16 0.405068 0.800792 Operations and Procedures Excision of other artery T 378957 498 378603 1.19 0.174493 0.209641 0.789 1.8 0.405216 0.800792 Operations and Procedures Other destruction of lesion of skin of head or neck T 378957 325 378776 0.765 -0.26774 0.321411 0.408 1.44 0.404836 0.800792 Operations and Procedures Elective caesarean delivery T 378957 1697 377404 1.11 0.10032 0.120658 0.873 1.4 0.405725 0.801141 Summary HESCH Chapter IX Diseases of the circulatory system BIN (HES) T 378957 117038 262063 0.985 -0.01552 0.018743 0.949 1.02 0.407616 0.802272 ENT Perforation of tympanic membrane (HES) T 378957 870 378231 1.15 0.135699 0.164123 0.83 1.58 0.408343 0.802272 Mental health Seen a psychiatrist for nerves anxiety tension or depression T 377176 43632 333688 0.978 -0.0218 0.026309 0.929 1.03 0.407366 0.802272 Operations and Procedures Extirpation of lesion of penis T 378957 221 378880 1.29 0.256084 0.309696 0.704 2.37 0.4083 0.802272 Operations and Procedures Freeing of tendon T 378957 652 378449 1.17 0.154845 0.187195 0.809 1.68 0.408131 0.802272 Infectious disease Mumps epidemic parotitis (HES and self-reported) T 378957 830 378271 1.15 0.136075 0.164347 0.83 1.58 0.407688 0.802272 Eye Corneal resistance factor left T 81021 NA NA NA -0.01469 0.017774 -0.04952 0.02015 0.408629 0.802272 Medication Antibiotics for topical use T 378957 1432 377669 1.11 0.106756 0.130165 0.862 1.44 0.412127 0.803122 Medication Corticosteroids other combinations T 378957 9688 369413 1.04 0.041813 0.051814 0.942 1.15 0.41968 0.803122 Summary Other osteopathies (HES) T 378957 2866 376235 0.921 -0.08217 0.099805 0.757 1.12 0.410319 0.803122 Summary Congenital malformations of genital organs (HES) T 378957 628 378473 0.836 -0.17957 0.222194 0.541 1.29 0.418985 0.803122 Eye Disorders of refraction and accommodation (HES) T 378957 1639 377462 1.1 0.097707 0.120161 0.871 1.4 0.416142 0.803122 Respiratory Diseases of vocal cords and larynx (HES) T 378957 1561 377540 0.895 -0.11095 0.137606 0.683 1.17 0.420064 0.803122 Immuno-inflammation Cellulitis (HES) T 378957 6570 372531 0.948 -0.05317 0.065368 0.834 1.08 0.415995 0.803122 Genitourinary Redundant prepuce phimosis and paraphimosis (HES) T 378957 1890 377211 1.1 0.093442 0.114975 0.876 1.38 0.416381 0.803122 Gynaecology and Obstetrics Gestational hypertension with significant proteinuria (HES) T 378957 289 378812 0.758 -0.27767 0.339916 0.389 1.47 0.413991 0.803122 Gynaecology and Obstetrics Retained placenta and membranes without haemorrhage (HES) T 378957 203 378898 0.715 -0.33508 0.415398 0.317 1.61 0.419873 0.803122 Medication Throat preparations T 378957 49826 329275 1.02 0.020159 0.024656 0.972 1.07 0.413566 0.803122 Medication Mydriatics and cycloplegics T 378957 287 378814 1.25 0.221605 0.274272 0.729 2.14 0.419105 0.803122 Gynaecology and Obstetrics Gynaecological surgery (self-reported) T 378957 2168 376933 1.09 0.086545 0.105584 0.887 1.34 0.412397 0.803122 Operations and Procedures Cystoscopy (self-reported) T 378957 345 378756 0.779 -0.24989 0.30668 0.427 1.42 0.415181 0.803122 Operations and Procedures Operations on lower respiratory tract T 378957 209 378892 0.716 -0.33421 0.414465 0.318 1.61 0.420038 0.803122 Operations and Procedures Attention to artificial opening into ileum T 378957 998 378103 1.13 0.124342 0.152884 0.839 1.53 0.416041 0.803122 Operations and Procedures Other exteriorisation of colon T 378957 934 378167 1.14 0.130043 0.158224 0.835 1.55 0.411141 0.803122 Operations and Procedures Diagnostic endoscopic retrograde examination of bile duct T 378957 309 378792 1.24 0.215174 0.264968 0.738 2.08 0.41675 0.803122 Operations and Procedures Endoscopic ultrasound examination of pancreas T 378957 605 378496 1.17 0.158159 0.193799 0.801 1.71 0.414446 0.803122 Operations and Procedures Other operations on vena cava T 378957 207 378894 0.713 -0.33851 0.414446 0.316 1.61 0.414052 0.803122 Operations and Procedures Transplantation of kidney T 378957 266 378835 1.26 0.233822 0.284642 0.723 2.21 0.411384 0.803122 Operations and Procedures Other operations on nail bed T 378957 686 378415 0.84 -0.17414 0.212353 0.554 1.27 0.412201 0.803122 Operations and Procedures Image controlled operations on abdominal cavity T 378957 419 378682 1.2 0.185574 0.22942 0.768 1.89 0.418583 0.803122 Operations and Procedures Biopsy of muscle T 378957 421 378680 1.21 0.187043 0.229351 0.769 1.89 0.414767 0.803122 Operations and Procedures Diagnostic endocrinology T 378957 1212 377889 0.881 -0.12686 0.157307 0.647 1.2 0.419989 0.803122 Operations and Procedures Other operations on intervertebral disc T 378957 298 378803 0.759 -0.27531 0.338683 0.391 1.47 0.416283 0.803122 Operations and Procedures Anaesthetic without surgery T 378957 299 378802 0.76 -0.27404 0.33869 0.391 1.48 0.41844 0.803122 NA Stroke T 378957 8703 370398 0.955 -0.0459 0.056857 0.854 1.07 0.419486 0.803122 Cardiovascular Pericardial problem (HES and self-reported) T 378957 1268 377833 0.884 -0.12362 0.152131 0.656 1.19 0.416448 0.803122 Neurosciences Spinal cord disorder (HES and self-reported) T 378957 1886 377215 0.905 -0.10016 0.12385 0.71 1.15 0.418692 0.803122 ENT Nasalsinus disorder (HES and self-reported) T 378957 11324 367777 1.04 0.0395 0.048311 0.946 1.14 0.413578 0.803122 Gynaecology and Obstetrics Ectopic pregnancy (HES and self-reported) T 378957 539 378562 0.82 -0.19788 0.240266 0.512 1.31 0.410183 0.803122 NA Pediatric asthma under16yo (self-reported) T 350450 15307 335270 1.03 0.033945 0.041813 0.953 1.12 0.416889 0.803122 Summary Other nutritional deficiencies (HES) T 378957 1249 377852 1.12 0.111329 0.138224 0.852 1.47 0.420577 0.803465 ENT Ent surgery (self-reported) T 378957 283 378818 1.25 0.220726 0.274376 0.728 2.14 0.421128 0.803881 Haematology Anaemia in chronic diseases classified elsewhere (HES) T 378957 657 378444 1.16 0.150093 0.187197 0.805 1.68 0.422674 0.804283 Neurosciences Paraplegia and tetraplegia (HES) T 378957 297 378804 0.762 -0.27207 0.338706 0.392 1.48 0.421823 0.804283 Digestive system Alcoholic liver disease (HES) T 378957 799 378302 1.15 0.138943 0.173287 0.818 1.61 0.422665 0.804283 Operations and Procedures Diagnostic transluminal operations on heart T 378957 1107 377994 0.877 -0.13105 0.163323 0.637 1.21 0.422318 0.804283 Cancer Mal neo ovary (cancer register) T 378957 893 378208 0.864 -0.14674 0.183251 0.603 1.24 0.423262 0.804513 Operations and Procedures Primary repair of incisional hernia T 378957 1622 377479 1.1 0.097436 0.121729 0.868 1.4 0.423463 0.804513 Gynaecology and Obstetrics Other abnormal products of conception (HES) T 378957 1191 377910 0.882 -0.12565 0.157316 0.648 1.2 0.424468 0.80468 Symptoms Abnormality of white blood cells (HES) T 378957 236 378865 0.736 -0.30655 0.383882 0.347 1.56 0.424553 0.80468 Operations and Procedures Antireflux operations T 378957 820 378281 0.857 -0.1538 0.192532 0.588 1.25 0.424391 0.80468 Digestive system Postprocedural disorders of digestive system (HES) T 378957 1429 377672 1.11 0.102968 0.129209 0.86 1.43 0.425504 0.80518 Musculoskeletal Other disorders of synovium and tendon (HES) T 378957 3447 375654 1.07 0.067664 0.085027 0.906 1.26 0.426154 0.80518 Gynaecology and Obstetrics Laser treatment cervix (self-reported) T 378957 611 378490 0.838 -0.17717 0.222495 0.542 1.3 0.425861 0.80518 Family history Breast cancer (family history - mother) T 350478 12118 338496 1.04 0.036975 0.046415 0.947 1.14 0.42567 0.80518 Musculoskeletal Other crystal arthropathies (HES) T 378957 369 378732 0.792 -0.23357 0.293749 0.445 1.41 0.426538 0.805274 Other Pattern 4 f T 173207 31573 141706 0.975 -0.02569 0.032337 0.915 1.04 0.426952 0.805425 Operations and Procedures Peripheral nerve surgery (self-reported) T 378957 794 378307 1.15 0.135612 0.17085 0.819 1.6 0.427343 0.805532 Operations and Procedures Operations on retinal membrane T 378957 983 378118 1.13 0.121279 0.153022 0.836 1.52 0.428036 0.805577 Digestive system Alcoholic liver disease alcoholic cirrhosis (HES and self-reported) T 378957 824 378277 1.15 0.135462 0.170852 0.819 1.6 0.427859 0.805577 Medication Other plain vitamin preparations T 378957 4840 374261 0.941 -0.06068 0.076719 0.81 1.09 0.429014 0.806488 Mental health Delirium not induced by alcohol and other psychoactive substances (HES) T 378957 538 378563 0.827 -0.18955 0.240103 0.517 1.32 0.429859 0.806488 Operations and Procedures Percutaneous examination of bile duct T 378957 260 378841 1.25 0.224923 0.284842 0.717 2.19 0.429738 0.806488 Operations and Procedures Operations on epididymis T 378957 1069 378032 1.13 0.118327 0.149792 0.839 1.51 0.429563 0.806488 Operations and Procedures Other operations on vulva T 378957 1300 377801 0.888 -0.11879 0.150627 0.661 1.19 0.430331 0.806745 Musculoskeletal Other rheumatoid arthritis (HES) T 378957 3989 375112 1.06 0.06258 0.079423 0.911 1.24 0.430735 0.806875 Digestive system Irritable bowel syndrome (HES and self-reported) T 378957 12379 366722 1.04 0.036314 0.046156 0.947 1.14 0.431426 0.807541 Symptoms Abnormalities of breathing (HES) T 378957 8413 370688 0.956 -0.0454 0.057866 0.853 1.07 0.432715 0.808614 Medication Hepatic and reticulo endothelial system T 378957 1728 377373 0.903 -0.10178 0.129709 0.7 1.16 0.432636 0.808614 Musculoskeletal Fracture thumb (HES and self-reported) T 378957 379 378722 0.794 -0.23019 0.293593 0.447 1.41 0.433006 0.808614 Operations and Procedures Excision of vulva T 378957 1147 377954 1.12 0.112538 0.143771 0.844 1.48 0.43377 0.809413 Gynaecology and Obstetrics Infections of genitourinary tract in pregnancy (HES) T 378957 212 378889 1.28 0.243507 0.311363 0.693 2.35 0.434174 0.80954 ENT Other disorders of tympanic membrane (HES) T 378957 333 378768 1.22 0.200329 0.256463 0.739 2.02 0.43473 0.809949 Neurosciences Parkinsons disease (HES and self-reported) T 378957 1191 377910 0.886 -0.12149 0.15579 0.653 1.2 0.435507 0.81077 Summary Disorders of adult personality and behaviour (HES) T 378957 350 378751 0.788 -0.23873 0.306594 0.432 1.44 0.43619 0.811414 Medication Antiobesity preparations excl diet products T 378957 958 378143 0.871 -0.13798 0.177427 0.615 1.23 0.436755 0.811839 Summary Abnormal findings on examination of blood without diagnosis (HES) T 378957 7295 371806 1.05 0.046165 0.059543 0.932 1.18 0.438157 0.812897 Mental health Recurrent depressive disorder (HES) T 378957 679 378422 0.849 -0.1642 0.212368 0.56 1.29 0.43942 0.812897 Gynaecology and Obstetrics Maternal care for other known or suspected fetal problems (HES) T 378957 1716 377385 1.1 0.092721 0.120191 0.867 1.39 0.44044 0.812897 Operations and Procedures Urethral stricture surgery dilatation (self-reported) T 378957 205 378896 0.726 -0.32003 0.414518 0.322 1.64 0.440087 0.812897 Mental health Probable recurrent major depression severe 2 T 54180 7072 47141 1.05 0.04991 0.064356 0.927 1.19 0.438026 0.812897 Cancer Mal neo stomach (cancer register) T 378957 377 378724 1.21 0.187013 0.241897 0.75 1.94 0.439456 0.812897 Operations and Procedures Exteriorisation of trachea T 378957 817 378284 0.862 -0.1485 0.192606 0.591 1.26 0.440699 0.812897 Operations and Procedures Other repair of vagina T 378957 332 378769 1.22 0.198051 0.256617 0.737 2.02 0.440246 0.812897 Gynaecology and Obstetrics Uterine problem (HES and self-reported) T 378957 29689 349412 1.02 0.024529 0.031746 0.963 1.09 0.439733 0.812897 ENT Speech reception threshold SRT estimate right T 114757 NA NA NA 0.011547 0.014905 -0.01767 0.040761 0.438529 0.812897 Genitourinary Unspecified renal colic (HES) T 378957 1752 377349 1.1 0.091235 0.118427 0.869 1.38 0.441069 0.812957 Summary Disorders of breast (HES) T 378957 4857 374244 0.943 -0.05853 0.076171 0.812 1.1 0.442236 0.813107 Metabolic Vitamin D deficiency (HES) T 378957 359 378742 1.21 0.19115 0.248753 0.743 1.97 0.442231 0.813107 Digestive system Other diseases of digestive system (HES) T 378957 8428 370673 0.957 -0.0444 0.057756 0.854 1.07 0.442056 0.813107 Musculoskeletal Disorders of continuity of bone (HES) T 378957 1398 377703 1.11 0.100789 0.131241 0.855 1.43 0.442506 0.813107 Medication Antiinflammatory agents T 378957 18165 360936 0.97 -0.03032 0.039503 0.898 1.05 0.442838 0.813107 Summary Hernia (HES) T 378957 42709 336392 1.02 0.020299 0.026485 0.969 1.07 0.443411 0.81327 Musculoskeletal Prolapsed discslipped disc (HES and self-reported) T 378957 8220 370881 1.04 0.043001 0.056128 0.935 1.17 0.443602 0.81327 Musculoskeletal Psoriatic and enteropathic arthropathies (HES) T 378957 650 378451 1.16 0.145149 0.190249 0.796 1.68 0.445496 0.813647 Family history Alzheimer s disease dementia (family history - mother) T 357389 29815 327714 0.976 -0.02393 0.031341 0.918 1.04 0.44518 0.813647 Operations and Procedures Other repair of peripheral nerve T 378957 526 378575 0.828 -0.18882 0.246758 0.51 1.34 0.444164 0.813647 Operations and Procedures Shave biopsy of skin T 378957 626 378475 1.16 0.145561 0.190436 0.796 1.68 0.444657 0.813647 Eye Retinal arteryvein occlusion (HES and self-reported) T 378957 614 378487 0.844 -0.16977 0.222364 0.546 1.3 0.445184 0.813647 Genitourinary Glomerulnephritis (HES and self-reported) T 378957 1746 377355 1.09 0.089719 0.117705 0.869 1.38 0.445923 0.813809 Operations and Procedures Transluminal operations on cerebral artery T 378957 1001 378100 1.12 0.117588 0.154474 0.831 1.52 0.44653 0.8143 Operations and Procedures Open excision of prostate T 378957 2046 377055 0.915 -0.08905 0.117187 0.727 1.15 0.447341 0.815162 Respiratory Cough on most days T 95656 13048 82648 0.964 -0.03658 0.048219 0.877 1.06 0.448018 0.815163 Digestive system Gastrointestinal bleeding (HES and self-reported) T 378957 8293 370808 0.957 -0.04419 0.058206 0.854 1.07 0.447779 0.815163 Neurosciences Mononeuropathy in diseases classified elsewhere (HES) T 378957 205 378896 0.731 -0.31399 0.414587 0.324 1.65 0.448831 0.81541 Operations and Procedures Examination of oesophagus T 378957 1296 377805 0.891 -0.11522 0.152048 0.662 1.2 0.448567 0.81541 Operations and Procedures Manipulation of spine T 378957 218 378883 1.26 0.233639 0.30967 0.688 2.32 0.450562 0.817938 Gynaecology and Obstetrics Dilatation and curettage d c (self-reported) T 378957 21385 357716 1.03 0.027513 0.0365 0.957 1.1 0.450994 0.818106 Operations and Procedures Extracorporeal fragmentation of calculus of ureter T 378957 563 378538 0.839 -0.17588 0.233703 0.531 1.33 0.451715 0.818182 Biological assays Urine albumin creatinine ratio T 114243 NA NA NA 0.011187 0.014856 -0.01793 0.040305 0.451414 0.818182 Medication Antithyroid preparations T 378957 334 378767 1.21 0.190023 0.256478 0.731 2 0.458759 0.818629 Summary Deforming dorsopathies (HES) T 378957 2539 376562 0.924 -0.07881 0.10503 0.752 1.14 0.453036 0.818629 Neurosciences Parkinson s disease (HES) T 378957 1054 378047 0.884 -0.12283 0.165668 0.639 1.22 0.458441 0.818629 Neurosciences Migraine (HES) T 378957 2516 376585 0.925 -0.07835 0.106105 0.751 1.14 0.460268 0.818629 Eye Other disorders of optic (HES) T 378957 285 378816 0.776 -0.25404 0.338935 0.399 1.51 0.453535 0.818629 Cardiovascular Other disorders of arteries and arterioles (HES) T 378957 1296 377805 0.895 -0.11128 0.150569 0.666 1.2 0.459884 0.818629 Digestive system Peptic ulcer site unspecified (HES) T 378957 370 378731 1.2 0.184853 0.24863 0.739 1.96 0.457187 0.818629 Immuno-inflammation Corns and callosities (HES) T 378957 257 378844 0.766 -0.26654 0.359425 0.379 1.55 0.458353 0.818629 Symptoms Cough (HES) T 378957 2614 376487 1.07 0.071918 0.097434 0.888 1.3 0.46044 0.818629 Symptoms Headache (HES) T 378957 6991 372110 0.954 -0.04757 0.063342 0.842 1.08 0.452653 0.818629 Cancer Malignant melanoma (self-reported) T 378957 2994 376107 1.07 0.067049 0.090802 0.895 1.28 0.460266 0.818629 Gynaecology and Obstetrics Uterine surgery (self-reported) T 378957 1594 377507 0.905 -0.09956 0.134296 0.696 1.18 0.458496 0.818629 Family history High blood pressure (family history - father) T 343458 74698 268894 0.984 -0.01591 0.021463 0.944 1.03 0.458457 0.818629 Operations and Procedures Repair of eardrum T 378957 1054 378047 1.12 0.111819 0.151064 0.832 1.5 0.459175 0.818629 Operations and Procedures Excision of oesophagus and stomach T 378957 219 378882 1.26 0.229921 0.309744 0.686 2.31 0.457909 0.818629 Operations and Procedures Excision of ileum T 378957 732 378369 1.14 0.131969 0.178434 0.804 1.62 0.459544 0.818629 Operations and Procedures Destruction of haemorrhoid T 378957 5384 373717 1.05 0.051457 0.069405 0.919 1.21 0.458453 0.818629 Operations and Procedures Other evacuation of contents of uterus T 378957 2583 376518 0.924 -0.07903 0.107177 0.749 1.14 0.46091 0.818629 Operations and Procedures Primary open reduction of intra articular fracture of bone T 378957 292 378809 0.777 -0.25172 0.338788 0.4 1.51 0.457488 0.818629 Operations and Procedures Other interposition reconstruction of joint T 378957 307 378794 0.787 -0.23981 0.321795 0.419 1.48 0.456134 0.818629 Operations and Procedures Delivery of oral chemotherapy for neoplasm T 378957 560 378541 0.84 -0.17392 0.233636 0.532 1.33 0.456638 0.818629 Operations and Procedures Other destruction of lesion of organ NOC T 378957 2552 376549 0.925 -0.07821 0.104954 0.753 1.14 0.456174 0.818629 Respiratory Pleurisy (HES and self-reported) T 378957 1687 377414 0.908 -0.0964 0.130737 0.703 1.17 0.460919 0.818629 Neurosciences Dementiaalzheimerscognitive impairment (HES and self-reported) T 378957 906 378195 1.13 0.119318 0.160402 0.823 1.54 0.456956 0.818629 Musculoskeletal Sclerodermasystemic sclerosis (HES and self-reported) T 378957 201 378900 0.736 -0.30698 0.414732 0.326 1.66 0.459186 0.818629 Immuno-inflammation Cellulitis (HES and self-reported) T 378957 6668 372433 0.953 -0.04771 0.064738 0.84 1.08 0.461137 0.818629 Neurosciences Incorect matches summed T 378957 NA NA NA -0.00621 0.00831 -0.0225 0.010078 0.454968 0.818629 Operations and Procedures Continuous Infusion of therapeutic substance T 378957 8393 370708 0.958 -0.0426 0.057953 0.855 1.07 0.462257 0.820013 Medication Stomatological preparations T 378957 59623 319478 0.983 -0.01696 0.023653 0.939 1.03 0.473298 0.821031 Medication Iron preparations T 378957 19982 359119 0.973 -0.0277 0.037806 0.903 1.05 0.463792 0.821031 Summary Extrapyramidal and movement disorders (HES) T 378957 1814 377287 0.914 -0.09013 0.124927 0.715 1.17 0.470621 0.821031 Summary Symptoms and signs involving the digestive system and abdomen (HES) T 378957 52090 327011 1.02 0.017657 0.024145 0.971 1.07 0.464598 0.821031 Mental health Somatoform disorders (HES) T 378957 381 378720 1.19 0.176518 0.241721 0.743 1.92 0.465235 0.821031 Neurosciences Inflammatory polyneuropathy (HES) T 378957 268 378833 1.23 0.207329 0.284593 0.704 2.15 0.466301 0.821031 Neurosciences Hydrocephalus (HES) T 378957 402 378699 1.19 0.172602 0.235283 0.749 1.88 0.463197 0.821031 Digestive system Gastric ulcer (HES) T 378957 3863 375238 0.94 -0.06175 0.085461 0.795 1.11 0.469945 0.821031 Digestive system Femoral hernia (HES) T 378957 558 378543 0.845 -0.16804 0.233687 0.535 1.34 0.472087 0.821031 Immuno-inflammation Granulomatous disorders of skin and subcutaneous tissue (HES) T 378957 534 378567 0.841 -0.17296 0.239999 0.526 1.35 0.471126 0.821031 Genitourinary Orchitis and epididymitis (HES) T 378957 769 378332 0.866 -0.144 0.199976 0.585 1.28 0.471477 0.821031 Medication Combinations of antibacterials T 378957 595 378506 0.849 -0.16342 0.227685 0.544 1.33 0.472906 0.821031 ENT Nasal sinus nose surgery (self-reported) T 378957 13231 365870 1.03 0.032384 0.044961 0.946 1.13 0.471359 0.821031 Operations and Procedures Radical prostatectomy (self-reported) T 378957 1237 377864 0.896 -0.10932 0.151257 0.666 1.21 0.469853 0.821031 Operations and Procedures Femoral hernia repair (self-reported) T 378957 326 378775 1.2 0.185042 0.256659 0.728 1.99 0.470932 0.821031 Family history Alzheimer s disease dementia (family history - father) T 343458 15771 327821 0.97 -0.03024 0.042208 0.893 1.05 0.473759 0.821031 Mental health Probable Recurrent major depression moderate T 91467 11528 79987 0.964 -0.03718 0.051728 0.871 1.07 0.472266 0.821031 Cancer Mal neo colon (cancer register) T 378957 2575 376526 0.927 -0.07604 0.104545 0.755 1.14 0.466999 0.821031 Cancer Neo of lymphoid haematopoietic (cancer register) T 378957 292 378809 1.22 0.19872 0.274192 0.713 2.09 0.468606 0.821031 Operations and Procedures Partial excision of ovary T 378957 433 378668 1.18 0.165152 0.229563 0.752 1.85 0.471884 0.821031 Operations and Procedures Opening of chest T 378957 257 378844 0.773 -0.25734 0.359485 0.382 1.56 0.474078 0.821031 Operations and Procedures Puncture of pleura T 378957 2582 376519 1.07 0.071529 0.097939 0.887 1.3 0.465178 0.821031 Operations and Procedures Primary fusion of other joint of spine T 378957 465 378636 0.833 -0.18295 0.254655 0.506 1.37 0.472503 0.821031 Operations and Procedures Secondary reduction of traumatic dislocation of joint T 378957 235 378866 0.759 -0.2761 0.383893 0.358 1.61 0.472009 0.821031 Operations and Procedures Puncture of organ NOC T 378957 315 378786 1.21 0.192069 0.264816 0.721 2.04 0.468271 0.821031 Operations and Procedures Spinal anaesthetic T 378957 6624 372477 1.05 0.045754 0.062557 0.926 1.18 0.464542 0.821031 Operations and Procedures Other anaesthetic T 378957 5945 373156 0.951 -0.04982 0.06821 0.832 1.09 0.465107 0.821031 Mental health Ever manic hyper for 2 days T 123436 7031 116467 0.955 -0.04595 0.064104 0.842 1.08 0.473497 0.821031 Infectious disease Tuberculosis tb (HES and self-reported) T 378957 1905 377196 1.09 0.082341 0.113386 0.869 1.36 0.467712 0.821031 Immuno-inflammation Food intolerance (HES and self-reported) T 378957 306 378795 1.21 0.191526 0.265035 0.72 2.04 0.4699 0.821031 Cardiovascular Mitral valve disease (HES and self-reported) T 378957 3385 375716 1.06 0.062529 0.085805 0.9 1.26 0.466166 0.821031 Musculoskeletal Bursitis (HES and self-reported) T 378957 2169 376932 0.921 -0.08258 0.114281 0.736 1.15 0.469905 0.821031 Anthropometry Waist circumference T 378288 NA NA NA -0.00598 0.008324 -0.0223 0.010333 0.472289 0.821031 Medication Selective calcium channel blockers with direct cardiac effects T 378957 3557 375544 0.939 -0.06339 0.088723 0.789 1.12 0.474957 0.821372 Cardiovascular Intracerebral haemorrhage (HES) T 378957 660 378441 0.859 -0.15195 0.212547 0.566 1.3 0.47468 0.821372 Cancer Mal neo bronchus and lung (cancer register) T 378957 1742 377359 1.09 0.084611 0.118614 0.863 1.37 0.475637 0.821958 Cancer Colon cancer sigmoid cancer (self-reported) T 378957 1220 377881 1.1 0.099492 0.139656 0.84 1.45 0.476213 0.822364 Operations and Procedures Transurethral resection of prostate turp (self-reported) T 378957 1932 377169 1.08 0.079364 0.111914 0.869 1.35 0.478229 0.824004 Operations and Procedures Reconstruction of eyelid T 378957 382 378719 1.19 0.171481 0.241735 0.739 1.91 0.478093 0.824004 Operations and Procedures Other operations on pharynx T 378957 503 378598 0.839 -0.175 0.246943 0.517 1.36 0.478531 0.824004 Operations and Procedures Plastic excision of skin of abdominal wall T 378957 228 378873 1.25 0.219723 0.30941 0.679 2.28 0.477619 0.824004 Eye Glaucoma (HES) T 378957 4047 375054 1.06 0.055221 0.07841 0.906 1.23 0.481275 0.825245 Symptoms Convulsions (HES) T 378957 1802 377299 1.09 0.082924 0.117572 0.863 1.37 0.480621 0.825245 Medication Antimycotics for systemic use T 378957 389 378712 1.19 0.170292 0.241596 0.738 1.9 0.480897 0.825245 Operations and Procedures Nephrectomy kidney removed (self-reported) T 378957 1353 377748 1.1 0.093983 0.13346 0.846 1.43 0.481307 0.825245 Cardiovascular Ecg electrocardiogram (self-reported) T 378957 201 378900 0.747 -0.29229 0.414617 0.331 1.68 0.48084 0.825245 Metabolic Gestational diabetes (HES and self-reported) T 378957 363 378738 0.813 -0.20747 0.294019 0.457 1.45 0.480424 0.825245 Summary Glaucoma (HES) T 378957 4048 375053 1.06 0.054909 0.07841 0.906 1.23 0.48375 0.825321 Neurosciences Hemiplegia (HES) T 378957 1363 377738 1.1 0.093584 0.133451 0.845 1.43 0.483143 0.825321 Family history Severe depression (family history - father) T 338597 12638 326091 1.03 0.032106 0.045647 0.944 1.13 0.481844 0.825321 ENT Hearing difficulty problems T 363510 94775 268869 1.01 0.013761 0.019625 0.976 1.05 0.483189 0.825321 Operations and Procedures Other open operations on uterus T 378957 285 378816 0.788 -0.2381 0.339141 0.405 1.53 0.482641 0.825321 Neurosciences Neck or shoulder pain T 378087 92289 285942 1.01 0.013574 0.019373 0.976 1.05 0.48351 0.825321 Neurosciences Brain haemorrhage (HES and self-reported) T 378957 1057 378044 0.89 -0.11632 0.16557 0.643 1.23 0.482327 0.825321 Biological assays Neutrophill count T 367067 NA NA NA -0.0059 0.008443 -0.02245 0.010647 0.484565 0.826127 Medication Corticosteroids combinations with antiseptics T 378957 6117 372984 1.05 0.04513 0.064699 0.922 1.19 0.485464 0.826397 Neurosciences Disorders of trigeminal nerve (HES) T 378957 419 378682 0.827 -0.18947 0.272066 0.485 1.41 0.486174 0.826397 Eye Other disorders of eyelid (HES) T 378957 5168 373933 1.05 0.048777 0.070139 0.915 1.2 0.486782 0.826397 Gynaecology and Obstetrics Hysteroscopy biopsy (self-reported) T 378957 1325 377776 1.1 0.093728 0.134775 0.843 1.43 0.48678 0.826397 Operations and Procedures Excision of lesion of tissue of brain T 378957 434 378667 1.17 0.159478 0.229186 0.748 1.84 0.486525 0.826397 Gynaecology and Obstetrics Pelvic inflammatory disease pid (HES and self-reported) T 378957 4037 375064 1.06 0.055189 0.079161 0.905 1.23 0.485699 0.826397 Genitourinary Other disorders of breast (HES) T 378957 1110 377991 0.894 -0.11185 0.161484 0.652 1.23 0.488521 0.828147 Operations and Procedures Oesophageal surgery (self-reported) T 378957 447 378654 0.833 -0.18216 0.262897 0.498 1.4 0.488374 0.828147 Operations and Procedures Transluminal operations on pulmonary artery T 378957 411 378690 0.823 -0.1953 0.282177 0.473 1.43 0.488854 0.828147 Musculoskeletal Fibromyalgia (HES and self-reported) T 378957 1223 377878 1.1 0.096563 0.139622 0.838 1.45 0.489188 0.828147 Immuno-inflammation Psoriasis (HES) T 378957 2058 377043 1.08 0.075968 0.109932 0.87 1.34 0.489534 0.828151 Symptoms Pain (HES) T 378957 1292 377809 1.1 0.094147 0.136935 0.84 1.44 0.491751 0.831269 Medication Corticosteroids and antiinfectives in combination 1 T 378957 5806 373295 1.05 0.045609 0.066386 0.919 1.19 0.492067 0.831269 Summary Abn exm of fluids subst wo diag (HES) T 378957 1857 377244 1.08 0.078708 0.11475 0.864 1.35 0.492771 0.831292 Neurosciences Posttraumatic stress disorder (HES and self-reported) T 378957 723 378378 0.869 -0.13988 0.203813 0.583 1.3 0.492522 0.831292 Operations and Procedures Intubation of stomach T 378957 329 378772 1.2 0.180853 0.264576 0.713 2.01 0.494255 0.833212 Summary Glucose regulation and pancreatic internal secretion (HES) T 378957 831 378270 0.879 -0.12921 0.189302 0.606 1.27 0.494898 0.833713 Operations and Procedures Other operations on spermatic cord T 378957 598 378503 1.14 0.134617 0.197493 0.777 1.68 0.495474 0.8341 Immuno-inflammation Urticaria (HES and self-reported) T 378957 530 378571 1.15 0.141841 0.209163 0.765 1.74 0.497684 0.837235 ENT Adenoid surgery adenoidectomy (self-reported) T 378957 2205 376896 1.07 0.070802 0.104761 0.874 1.32 0.499142 0.839102 Operations and Procedures Extirpation of lesion of upper gastrointestinal tract T 378957 1015 378086 1.11 0.104234 0.154509 0.82 1.5 0.499923 0.839829 Operations and Procedures Therapeutic endoscopic operations on other joint structure T 378957 4753 374348 1.05 0.049 0.07294 0.91 1.21 0.501718 0.842257 Musculoskeletal Trunk BMD bone mineral density T 4100 NA NA NA -0.05782 0.086229 -0.22683 0.111192 0.502538 0.843046 Metabolic Other disorders of pancreatic internal secretion (HES) T 378957 829 378272 0.881 -0.12678 0.18931 0.608 1.28 0.503066 0.843344 Medication Intestinal antiinfectives T 378957 693 378408 0.87 -0.13916 0.208001 0.579 1.31 0.503466 0.843428 Eye Retinal vascular occlusions (HES) T 378957 466 378635 0.845 -0.16877 0.254716 0.513 1.39 0.507603 0.843952 Digestive system Diseases of salivary glands (HES) T 378957 909 378192 0.887 -0.11989 0.180231 0.623 1.26 0.505912 0.843952 Operations and Procedures Hernia surgery (self-reported) T 378957 2430 376671 1.07 0.066738 0.100815 0.877 1.3 0.507983 0.843952 Operations and Procedures Other operations on ear T 378957 414 378687 1.17 0.155914 0.235109 0.737 1.85 0.507229 0.843952 Operations and Procedures Division of fascia T 378957 394 378707 0.829 -0.18805 0.28233 0.476 1.44 0.505381 0.843952 Haematology Pernicious anaemia (HES and self-reported) T 378957 1499 377602 1.09 0.084974 0.128158 0.847 1.4 0.507304 0.843952 Digestive system Ulcerative colitis (HES and self-reported) T 378957 3555 375546 0.943 -0.05881 0.088811 0.792 1.12 0.507861 0.843952 Cardiovascular Wolff parkinson white wpw syndrome (HES and self-reported) T 378957 228 378873 1.23 0.205475 0.309292 0.67 2.25 0.506472 0.843952 Cardiovascular Svt supraventricular tachycardia (HES and self-reported) T 378957 2281 376820 0.929 -0.07356 0.110926 0.748 1.15 0.507226 0.843952 Musculoskeletal Fracture wrist colles fracture (HES and self-reported) T 378957 3198 375903 0.94 -0.06223 0.09385 0.782 1.13 0.507285 0.843952 Family history High blood pressure (family history) T 378957 NA NA NA 0.005533 0.008305 -0.01075 0.021811 0.505304 0.843952 Biological assays Microalbumin in urine T 114244 NA NA NA 0.009892 0.014859 -0.01923 0.039016 0.505607 0.843952 Summary Mal neo of lip oral cavity and pharynx (cancer register) T 378957 799 378302 0.881 -0.12642 0.192659 0.604 1.29 0.511697 0.849061 Operations and Procedures Diagnostic lower respiratory tract T 378957 4809 374292 0.951 -0.05012 0.076393 0.819 1.1 0.511763 0.849061 Operations and Procedures Diagnostic imaging of musculoskeletal system T 378957 820 378281 0.883 -0.1241 0.189319 0.609 1.28 0.51216 0.849135 Operations and Procedures Other non operations T 378957 2978 376123 0.936 -0.06639 0.10142 0.767 1.14 0.512737 0.849507 Medication Cicatrizants T 378957 2968 376133 0.938 -0.06406 0.098027 0.774 1.14 0.513441 0.849536 Genitourinary Female infertility (HES) T 378957 923 378178 1.11 0.105418 0.161745 0.809 1.53 0.514559 0.849536 Medication Antiinflammatory agents and antiinfectives in combination T 378957 17347 361754 0.974 -0.02627 0.040303 0.9 1.05 0.514527 0.849536 Family history Lung cancer (family history - sibling) T 301109 6394 294842 0.958 -0.04337 0.066525 0.841 1.09 0.514454 0.849536 Operations and Procedures Other excision of bone T 378957 3701 375400 0.945 -0.05641 0.08662 0.798 1.12 0.51487 0.849536 ENT Sleep apnoea (HES and self-reported) T 378957 4559 374542 0.95 -0.05105 0.078342 0.815 1.11 0.51467 0.849536 Summary Chronic lower respiratory diseases (HES) T 378957 30351 348750 1.02 0.01984 0.030514 0.961 1.08 0.515577 0.85012 Eye Other disorders of lens (HES) T 378957 203 378898 1.23 0.210632 0.324557 0.653 2.33 0.516349 0.850229 Operations and Procedures Primary repair of umbilical hernia T 378957 3099 376002 0.94 -0.06178 0.095174 0.78 1.13 0.51624 0.850229 Infectious disease Dermatophytosis (HES) T 378957 227 378874 1.22 0.200454 0.309394 0.666 2.24 0.517055 0.850229 Symptoms General sensations and perceptions (HES) T 378957 472 378629 0.848 -0.16503 0.254537 0.515 1.4 0.516754 0.850229 Immuno-inflammation Decubitus ulcer (HES) T 378957 840 378261 0.887 -0.12045 0.186262 0.615 1.28 0.517855 0.850362 Operations and Procedures Other operations on lip T 378957 464 378637 1.16 0.144246 0.22357 0.745 1.79 0.518802 0.850362 Operations and Procedures Harvest of tendon T 378957 532 378569 0.856 -0.15523 0.240012 0.535 1.37 0.517777 0.850362 Eye Diabetes related eye disease T 124323 2369 122007 0.932 -0.06989 0.108173 0.754 1.15 0.518241 0.850362 Cardiovascular Pericardial effusion (HES and self-reported) T 378957 600 378501 0.866 -0.14345 0.222394 0.56 1.34 0.518901 0.850362 Mental health Phobic anxiety disorders (HES) T 378957 527 378574 1.14 0.134661 0.209198 0.759 1.72 0.519767 0.850624 Operations and Procedures Removal of rodent ulcer basal cell carcinoma bcc (self-reported) T 378957 957 378144 1.11 0.10071 0.156404 0.814 1.5 0.519635 0.850624 Summary Glomerular diseases (HES) T 378957 1942 377159 1.07 0.07227 0.112618 0.862 1.34 0.521048 0.851564 Cancer Mal neo testis (cancer register) T 378957 451 378650 1.16 0.147163 0.229264 0.739 1.82 0.520944 0.851564 Summary Other joint disorders (HES) T 378957 35549 343552 0.982 -0.01823 0.028742 0.928 1.04 0.525907 0.852572 Respiratory Other interstitial pulmonary diseases (HES) T 378957 930 378171 1.11 0.102407 0.160138 0.809 1.52 0.522504 0.852572 Genitourinary Unspecified renal failure (HES) T 378957 1276 377825 1.09 0.087916 0.138274 0.833 1.43 0.5249 0.852572 Symptoms Fever of unknown origin (HES) T 378957 3729 375372 1.05 0.052462 0.082269 0.897 1.24 0.523679 0.852572 Medication Muscle relaxants centrally acting agents T 378957 555 378546 0.861 -0.14933 0.233659 0.545 1.36 0.522771 0.852572 Operations and Procedures Excision of thyroid gland T 378957 1898 377203 0.925 -0.07743 0.122202 0.728 1.18 0.526336 0.852572 Operations and Procedures Endoscopic extirpation of lesion of bladder T 378957 2389 376712 0.934 -0.06847 0.108103 0.756 1.15 0.526504 0.852572 Operations and Procedures Operations on prepuce T 378957 2323 376778 1.07 0.066529 0.105032 0.87 1.31 0.52646 0.852572 Operations and Procedures Split autograft of skin T 378957 1318 377783 1.09 0.086765 0.135772 0.836 1.42 0.522791 0.852572 Operations and Procedures Suture of skin of other site T 378957 2266 376835 1.07 0.066928 0.105229 0.87 1.31 0.524761 0.852572 Operations and Procedures Total prosthetic replacement of other joint not using cement T 378957 305 378796 0.816 -0.20374 0.321781 0.434 1.53 0.52662 0.852572 Operations and Procedures High cost immunology drugs T 378957 340 378761 1.18 0.163291 0.256372 0.712 1.95 0.524171 0.852572 Gynaecology and Obstetrics Breast disease not cancer (HES and self-reported) T 378957 3704 375397 0.946 -0.05501 0.086858 0.798 1.12 0.526508 0.852572 Musculoskeletal Fracture lower leg ankle (HES and self-reported) T 378957 6609 372492 1.04 0.039757 0.062411 0.921 1.18 0.524113 0.852572 Respiratory Pulmonary fibrosis (HES and self-reported) T 378957 789 378312 0.885 -0.12164 0.192801 0.607 1.29 0.528093 0.854383 Operations and Procedures Neurophysiological operations T 378957 2161 376940 0.93 -0.07238 0.115008 0.742 1.17 0.529112 0.854597 Operations and Procedures Other operations on conjunctiva T 378957 712 378389 1.12 0.112204 0.178667 0.788 1.59 0.529999 0.854597 Operations and Procedures Other connection of stomach to jejunum T 378957 256 378845 0.797 -0.22648 0.359406 0.394 1.61 0.528602 0.854597 Operations and Procedures Combined operations on varicose vein of leg T 378957 1623 377478 0.92 -0.08354 0.132933 0.709 1.19 0.529733 0.854597 Respiratory Other respiratory problems (HES and self-reported) T 378957 5684 373417 1.04 0.042315 0.067306 0.914 1.19 0.529544 0.854597 Eye Retinal detachments and breaks (HES) T 378957 2997 376104 1.06 0.05674 0.090867 0.886 1.26 0.532345 0.856088 Medication Anesthetics general T 378957 221 378880 0.787 -0.23998 0.384282 0.37 1.67 0.532307 0.856088 Gynaecology and Obstetrics Breast biopsy (self-reported) T 378957 375 378726 0.838 -0.1765 0.282626 0.482 1.46 0.532312 0.856088 Genitourinary Haemorrhoids piles (HES and self-reported) T 378957 1010 378091 0.9 -0.10498 0.167845 0.648 1.25 0.531685 0.856088 Haematology Polycythaemia vera (HES and self-reported) T 378957 393 378708 1.16 0.150559 0.241628 0.724 1.87 0.533216 0.856916 Operations and Procedures Diagnostic spinal puncture T 378957 4837 374264 0.954 -0.04714 0.075863 0.822 1.11 0.534339 0.857006 Operations and Procedures Diagnostic endoscopic examination of pharynx T 378957 3123 375978 1.06 0.05596 0.09004 0.886 1.26 0.534268 0.857006 Operations and Procedures Injection of therapeutic substance T 378957 1288 377813 1.09 0.08595 0.138209 0.831 1.43 0.534017 0.857006 Medication Antifibrinolytics T 378957 502 378599 1.14 0.133026 0.214347 0.75 1.74 0.534856 0.857264 Musculoskeletal Other enthesopathies (HES) T 378957 1540 377561 0.92 -0.0838 0.135294 0.705 1.2 0.535658 0.857842 Summary Mal neo of urinary tract (cancer register) T 378957 1919 377182 1.07 0.069834 0.112821 0.86 1.34 0.535929 0.857842 Operations and Procedures Other operations on middle ear T 378957 277 378824 1.19 0.175301 0.284333 0.683 2.08 0.537542 0.859319 Operations and Procedures Diagnostic endoscopic examination of uterus T 378957 20331 358770 1.02 0.023052 0.037392 0.951 1.1 0.537565 0.859319 Medication Emollients and protectives T 378957 1288 377813 0.913 -0.09128 0.148903 0.682 1.22 0.539877 0.860161 Summary Cerebrovascular diseases (HES) T 378957 7435 371666 0.963 -0.03755 0.061166 0.854 1.09 0.539323 0.860161 Operations and Procedures Diagnostic electrocardiography T 378957 998 378103 0.9 -0.10571 0.172416 0.642 1.26 0.539817 0.860161 Operations and Procedures Division of bone of foot T 378957 4767 374334 0.954 -0.04695 0.076373 0.821 1.11 0.538751 0.860161 Musculoskeletal Pelvis BMD bone mineral density T 4100 NA NA NA -0.05287 0.086183 -0.22179 0.116047 0.539564 0.860161 Immuno-inflammation Cutaneous abscess furuncle and carbuncle (HES) T 378957 2145 376956 1.07 0.066059 0.108074 0.864 1.32 0.541039 0.860306 Metabolic Pituitary adenomatumour (HES and self-reported) T 378957 466 378635 0.856 -0.15578 0.254603 0.52 1.41 0.540626 0.860306 Infectious disease Chickenpox (HES and self-reported) T 378957 1557 377544 1.08 0.075505 0.123519 0.847 1.37 0.541011 0.860306 Biological assays Haematocrit percentage T 367722 NA NA NA 0.005149 0.008437 -0.01139 0.021687 0.541666 0.860734 Medication Irrigating solutions T 378957 1449 377652 1.08 0.079205 0.130229 0.839 1.4 0.543056 0.862336 Digestive system Diseases of pulp and periapical tissues (HES) T 378957 2104 376997 1.07 0.066409 0.10928 0.863 1.32 0.54339 0.862336 Neurosciences Other mononeuropathies (HES) T 378957 306 378795 0.823 -0.1951 0.321731 0.438 1.55 0.544248 0.863129 Operations and Procedures Other operations on anus T 378957 1643 377458 0.923 -0.07981 0.131829 0.713 1.2 0.544886 0.863573 Cardiovascular Other cerebrovascular diseases (HES) T 378957 2188 376913 0.934 -0.06815 0.113049 0.748 1.17 0.546599 0.865182 Genitourinary Other noninflammatory disorders of cervix uteri (HES) T 378957 1621 377480 1.08 0.073968 0.122791 0.846 1.37 0.546912 0.865182 Family history Severe depression (family history) T 378957 NA NA NA 0.004998 0.008298 -0.01127 0.021261 0.546979 0.865182 Operations and Procedures Foot surgery (self-reported) T 378957 7430 371671 1.04 0.035423 0.058938 0.923 1.16 0.547828 0.865956 Operations and Procedures Bladder surgery (self-reported) T 378957 2401 376700 1.06 0.060961 0.10164 0.871 1.3 0.548659 0.866432 Neurosciences Diabetic neuropathyulcers (HES and self-reported) T 378957 546 378555 0.869 -0.14016 0.233803 0.55 1.37 0.548848 0.866432 Operations and Procedures Photocoagulation of retina for detachment T 378957 972 378129 0.902 -0.10327 0.17247 0.643 1.26 0.549319 0.866607 Symptoms Polyuria (HES) T 378957 3507 375594 1.05 0.050829 0.085049 0.891 1.24 0.550074 0.86693 Symptoms Dizziness and giddiness (HES) T 378957 4147 374954 1.05 0.046967 0.078619 0.898 1.22 0.550243 0.86693 Operations and Procedures Extirpation of lesion of other part of mouth T 378957 688 378413 0.883 -0.124 0.208024 0.588 1.33 0.55111 0.867728 Musculoskeletal Total BMD bone mineral density T 4100 NA NA NA -0.05126 0.086307 -0.22042 0.117905 0.552587 0.869485 Operations and Procedures Operations on other articular cartilage T 378957 1114 377987 1.09 0.087564 0.147856 0.817 1.46 0.553698 0.870111 Operations and Procedures Connection of organ NOC T 378957 354 378747 0.84 -0.17407 0.293928 0.472 1.49 0.553707 0.870111 Family history Lung cancer (family history - mother) T 354043 14282 339899 1.03 0.02569 0.043486 0.942 1.12 0.554682 0.871075 Metabolic Thyroiditis (HES) T 378957 275 378826 1.18 0.167257 0.284452 0.677 2.06 0.556533 0.872844 Symptoms Unspecified jaundice (HES) T 378957 839 378262 0.896 -0.10952 0.186212 0.622 1.29 0.55643 0.872844 Metabolic Volume depletion (HES) T 378957 2592 376509 1.06 0.057628 0.098346 0.874 1.28 0.557896 0.874412 Infectious disease Other bacterial intestinal infections (HES) T 378957 2315 376786 1.06 0.061103 0.104668 0.866 1.31 0.559372 0.875586 Operations and Procedures Skin operation or plastic surgery (self-reported) T 378957 3215 375886 1.05 0.051809 0.088675 0.885 1.25 0.559051 0.875586 Operations and Procedures Other operations on joint T 378957 520 378581 0.869 -0.14003 0.2401 0.543 1.39 0.559764 0.875631 Summary Diseases of oral cavity salivary glands and jaws (HES) T 378957 14224 364877 0.974 -0.02583 0.044374 0.893 1.06 0.560486 0.876191 Mental health Unspecified dementia (HES) T 378957 432 378669 1.14 0.133366 0.229427 0.729 1.79 0.561038 0.876485 Medication Antiinflammatory and antirheumatic products non steroids T 378957 86308 292793 0.988 -0.01158 0.019967 0.951 1.03 0.561957 0.877352 Mental health Probable Recurrent major depression severe 1 T 91467 6715 84800 1.04 0.036918 0.063724 0.916 1.18 0.562359 0.877411 Operations and Procedures Removal of benign skin lesion (self-reported) T 378957 629 378472 1.12 0.111884 0.193592 0.765 1.63 0.563308 0.877755 Operations and Procedures Ventilation support T 378957 2964 376137 0.945 -0.05627 0.097282 0.781 1.14 0.562962 0.877755 Operations and Procedures Other operations on skin T 378957 1061 378040 0.909 -0.09556 0.165531 0.657 1.26 0.563748 0.877873 Operations and Procedures Graft to organ NOC T 378957 624 378477 0.882 -0.12522 0.21729 0.576 1.35 0.564424 0.878358 Medication Anti dementia drugs T 378957 2265 376836 0.938 -0.06369 0.11102 0.755 1.17 0.566184 0.87996 Cancer Chronic lymphocytic (self-reported) T 378957 244 378857 0.813 -0.20645 0.359746 0.402 1.65 0.566052 0.87996 Summary Other viral diseases (HES) T 378957 1781 377320 1.07 0.067407 0.118325 0.848 1.35 0.568898 0.880272 Summary Diseases of external ear (HES) T 378957 1324 377777 1.08 0.076112 0.13572 0.827 1.41 0.574933 0.880272 Summary Lung diseases due to external agents (HES) T 378957 898 378203 1.1 0.092687 0.164176 0.795 1.51 0.572373 0.880272 Summary HESCH Diseases of the blood forming organ immune mech BIN (HES) T 378957 22345 356756 0.98 -0.02005 0.035664 0.914 1.05 0.574039 0.880272 Eye Disorders of vitreous body (HES) T 378957 1246 377855 1.08 0.077935 0.138324 0.824 1.42 0.573147 0.880272 Digestive system Dentofacial anomalies (HES) T 378957 538 378563 1.13 0.118075 0.209111 0.747 1.7 0.572312 0.880272 Digestive system Abscess of anal and rectal regions (HES) T 378957 1208 377893 1.09 0.081783 0.143444 0.819 1.44 0.568583 0.880272 Genitourinary Other noninflammatory disorders of uterus except cervix (HES) T 378957 4717 374384 0.958 -0.04273 0.076311 0.825 1.11 0.57552 0.880272 Gynaecology and Obstetrics Single delivery by caesarean section (HES) T 378957 504 378597 0.871 -0.13824 0.241675 0.542 1.4 0.567314 0.880272 Symptoms Faecal incontinence (HES) T 378957 1634 377467 1.07 0.069634 0.12342 0.842 1.37 0.572615 0.880272 Symptoms Abnormalities of gait and mobility (HES) T 378957 1676 377425 0.93 -0.07274 0.129793 0.721 1.2 0.5752 0.880272 Symptoms Other lack of coordination (HES) T 378957 322 378779 1.16 0.150161 0.264679 0.692 1.95 0.570487 0.880272 Medication Hypnotics and sedatives T 378957 3007 376094 1.05 0.052088 0.091497 0.881 1.26 0.569159 0.880272 Operations and Procedures Spine or back surgery (self-reported) T 378957 4637 374464 1.04 0.041843 0.074042 0.902 1.21 0.571986 0.880272 Family history Bowel cancer (family history - mother) T 354043 17920 336261 0.978 -0.02226 0.039607 0.905 1.06 0.574182 0.880272 Gynaecology and Obstetrics Ever had hysterectomy womb removed T 180479 14618 165925 0.975 -0.02546 0.04535 0.892 1.07 0.574516 0.880272 Operations and Procedures Other operations on maxillary antrum T 378957 2872 376229 0.946 -0.05557 0.098927 0.779 1.15 0.574303 0.880272 Operations and Procedures Removal of other substance from skin T 378957 434 378667 0.862 -0.14802 0.262962 0.515 1.44 0.573504 0.880272 Operations and Procedures Diagnostic blood tests T 378957 378 378723 1.15 0.14205 0.248448 0.708 1.88 0.567491 0.880272 Operations and Procedures Release of contracture of joint T 378957 1613 377488 1.07 0.069683 0.123387 0.842 1.37 0.572242 0.880272 Operations and Procedures Excision of lesion of organ NOC T 378957 2108 376993 1.06 0.061904 0.109278 0.859 1.32 0.571065 0.880272 Cardiovascular Hypertension (HES and self-reported) T 378957 98025 281076 0.989 -0.01107 0.019599 0.952 1.03 0.572307 0.880272 Cardiovascular Pulse wave Arterial Stiffness index T 124901 NA NA NA 0.008098 0.014377 -0.02008 0.036277 0.573228 0.880272 Cardiovascular LV end systolic volume T 3764 NA NA NA 0.050852 0.089794 -0.12514 0.226847 0.571178 0.880272 Cardiovascular LVEDVi T 3760 NA NA NA 0.051063 0.089766 -0.12488 0.227005 0.569462 0.880272 Other Chest pain or discomfort T 375050 59237 315955 0.987 -0.0129 0.02311 0.943 1.03 0.576766 0.881575 Neurosciences Other neurological problem (HES and self-reported) T 378957 8378 370723 1.03 0.031123 0.055814 0.925 1.15 0.577104 0.881575 Cancer Non hodgkins lymphoma (self-reported) T 378957 719 378382 0.895 -0.1113 0.200023 0.605 1.32 0.577902 0.882149 Operations and Procedures General anaesthetic T 378957 13536 365565 0.975 -0.02522 0.045365 0.892 1.07 0.578212 0.882149 Summary Viral infections of the central nervous system (HES) T 378957 233 378868 1.19 0.17129 0.309131 0.648 2.18 0.579509 0.882237 Cancer Large bowel cancer colorectal cancer (self-reported) T 378957 526 378575 1.12 0.116102 0.209321 0.745 1.69 0.579129 0.882237 Cancer Hodgkins lymphoma hodgkins disease (self-reported) T 378957 352 378749 1.15 0.141839 0.256132 0.698 1.9 0.579735 0.882237 Operations and Procedures Other manipulation of joint T 378957 2050 377051 1.06 0.060977 0.109957 0.857 1.32 0.579199 0.882237 Operations and Procedures Open approach to contents of cranium T 378957 800 378301 0.901 -0.10452 0.189405 0.621 1.31 0.581048 0.883677 Symptoms Symptoms the circulatory and respiratory systems (HES) T 378957 1000 378101 1.09 0.085932 0.156181 0.802 1.48 0.582177 0.884662 Other Chest pain or discomfort walking normally T 58703 10166 48566 1.03 0.030971 0.056363 0.924 1.15 0.582664 0.884662 Operations and Procedures Perineal operations for prolapse of rectum T 378957 257 378844 1.18 0.162551 0.295921 0.659 2.1 0.582797 0.884662 Gynaecology and Obstetrics Lumpectomy (self-reported) T 378957 12746 366355 0.975 -0.02581 0.047117 0.889 1.07 0.583811 0.884778 Operations and Procedures Dupuytren s contracture surgery (self-reported) T 378957 409 378692 1.14 0.128882 0.235371 0.717 1.8 0.583987 0.884778 Operations and Procedures Diagnostic endoscopic examination of fallopian tube T 378957 293 378808 1.17 0.155814 0.284799 0.669 2.04 0.584309 0.884778 Operations and Procedures Approach to organ through artery T 378957 284 378817 0.838 -0.17637 0.322406 0.446 1.58 0.584343 0.884778 Immuno-inflammation Other disorders involving the immune mechanism (HES) T 378957 290 378811 0.84 -0.17424 0.322058 0.447 1.58 0.588491 0.886922 Gynaecology and Obstetrics Maternal care for known or suspected abnormality of pelvic organs (HES) T 378957 1384 377717 1.08 0.072463 0.134012 0.827 1.4 0.588699 0.886922 Cardiovascular Aortic valve repair replacement (self-reported) T 378957 561 378540 0.884 -0.1233 0.228031 0.565 1.38 0.588704 0.886922 Operations and Procedures Secondary open reduction of fracture of bone T 378957 1013 378088 0.913 -0.09105 0.167779 0.657 1.27 0.587364 0.886922 Metabolic Adrenocortical insufficiencyaddisons disease (HES and self-reported) T 378957 349 378752 0.853 -0.15936 0.293983 0.479 1.52 0.587759 0.886922 Musculoskeletal Ankylosing spondylitis (HES and self-reported) T 378957 1308 377793 0.923 -0.07983 0.147362 0.692 1.23 0.588014 0.886922 Digestive system Appendicitis (HES and self-reported) T 378957 6308 372793 1.04 0.034785 0.063924 0.913 1.17 0.586331 0.886922 Eye Corneal hysteresis left T 81021 NA NA NA 0.009649 0.01777 -0.02518 0.044478 0.587141 0.886922 Metabolic Other disorders of adrenal gland (HES) T 378957 431 378670 0.869 -0.14065 0.262991 0.519 1.45 0.592795 0.887535 Neurosciences Mononeuropathies of lower limb (HES) T 378957 1479 377622 1.07 0.069095 0.129166 0.832 1.38 0.592697 0.887535 Medication Corticosteroids T 378957 6270 372831 1.04 0.034541 0.064192 0.913 1.17 0.590519 0.887535 Cancer Kidney renal cell cancer (self-reported) T 378957 493 378608 1.12 0.117163 0.218426 0.733 1.73 0.591684 0.887535 Operations and Procedures Lymph node surgery (self-reported) T 378957 763 378338 1.1 0.094261 0.175792 0.779 1.55 0.591817 0.887535 Family history High blood pressure (family history - mother) T 357389 106967 250562 1.01 0.010064 0.018802 0.974 1.05 0.592476 0.887535 Operations and Procedures Reconstruction of ossicular chain T 378957 220 378881 0.813 -0.2068 0.384318 0.383 1.73 0.590503 0.887535 Operations and Procedures Other bypass of femoral artery T 378957 274 378827 0.834 -0.18153 0.339343 0.429 1.62 0.592691 0.887535 Operations and Procedures Normal delivery T 378957 6515 372586 1.04 0.036871 0.068524 0.907 1.19 0.590519 0.887535 Operations and Procedures Diagnostic echocardiography T 378957 8855 370246 0.971 -0.02984 0.055757 0.87 1.08 0.592549 0.887535 Eye Paralytic strabismus (HES) T 378957 258 378843 1.17 0.157825 0.295868 0.656 2.09 0.593735 0.887838 Medication Adrenergics for systemic use T 378957 22332 356769 1.02 0.018746 0.035122 0.951 1.09 0.593532 0.887838 Genitourinary Ureteric obstructionhydronephrosis (HES and self-reported) T 378957 2626 376475 0.947 -0.05481 0.102886 0.774 1.16 0.594245 0.88805 Eye Dry eyes (HES and self-reported) T 378957 847 378254 0.908 -0.09701 0.183356 0.634 1.3 0.596745 0.891233 Operations and Procedures Diagnostic imaging of vascular system T 378957 1073 378028 1.08 0.079736 0.15102 0.806 1.46 0.597513 0.891827 Digestive system Dental caries (HES) T 378957 2856 376245 0.95 -0.0518 0.098504 0.783 1.15 0.599008 0.892082 Medication Antihistamines for systemic use T 378957 13321 365780 0.976 -0.02395 0.045571 0.893 1.07 0.599165 0.892082 Operations and Procedures Correction of ptosis of eyelid T 378957 747 378354 1.1 0.093835 0.178396 0.774 1.56 0.598892 0.892082 Mental health Stress (HES and self-reported) T 378957 662 378439 1.11 0.100045 0.190173 0.761 1.6 0.598836 0.892082 Summary Mal neo of respiratory and intrathoracic organs (cancer register) T 378957 2026 377075 1.06 0.058476 0.111414 0.852 1.32 0.599686 0.892306 Operations and Procedures Examination of upper gastrointestinal tract T 378957 65264 313837 0.988 -0.01168 0.022327 0.946 1.03 0.600817 0.892886 Operations and Procedures Extirpation of nail bed T 378957 679 378422 1.1 0.099478 0.190066 0.761 1.6 0.600707 0.892886 Summary Other diseases of upper respiratory tract (HES) T 378957 13139 365962 1.02 0.023471 0.045321 0.937 1.12 0.604536 0.893029 Metabolic Hyperparathyroidism of parathyroid gland (HES) T 378957 752 378349 1.1 0.092464 0.178363 0.773 1.56 0.604179 0.893029 Symptoms Other abnormal findings of blood chemistry (HES) T 378957 5815 373286 1.04 0.034645 0.066718 0.908 1.18 0.603564 0.893029 Medication Cough suppressants excl combinations with expectorants T 378957 2402 376699 0.945 -0.05626 0.107838 0.765 1.17 0.601899 0.893029 ENT Tonsillectomy tonsil surgery (self-reported) T 378957 17457 361644 0.98 -0.02057 0.039592 0.906 1.06 0.603325 0.893029 Eye Wears glasses or contact lenses T 378384 337207 41321 0.985 -0.01506 0.029109 0.93 1.04 0.604991 0.893029 Operations and Procedures Other operations on external ear T 378957 435 378666 0.872 -0.13719 0.263008 0.521 1.46 0.601928 0.893029 Operations and Procedures Other operations on tooth T 378957 286 378815 1.16 0.147425 0.284106 0.664 2.02 0.603826 0.893029 Operations and Procedures Ligation of varicose vein of leg T 378957 5765 373336 0.965 -0.03604 0.069504 0.842 1.11 0.604038 0.893029 Operations and Procedures Primary decompression operations on cervical spine T 378957 557 378544 0.889 -0.11816 0.227963 0.568 1.39 0.60424 0.893029 Musculoskeletal Fracture rib (HES and self-reported) T 378957 2085 377016 0.942 -0.05992 0.115816 0.751 1.18 0.604909 0.893029 Neurosciences Other demyelinating disease not multiple sclerosi (HES and self-reported) T 378957 1324 377777 1.07 0.070387 0.136876 0.82 1.4 0.607082 0.895019 ENT Earvestibular disorder (HES and self-reported) T 378957 12078 367023 1.02 0.02414 0.046916 0.934 1.12 0.606879 0.895019 Medication Adrenergics inhalants T 378957 26289 352812 1.02 0.016715 0.032572 0.954 1.08 0.607829 0.895024 Cardiovascular Rheumatic fever (HES and self-reported) T 378957 3026 376075 1.05 0.046865 0.09125 0.876 1.25 0.607536 0.895024 Symptoms Abnormal findings on diagnostic imaging of lung (HES) T 378957 2263 376838 1.06 0.05397 0.105854 0.858 1.3 0.610155 0.897901 Summary Number of operations self reported T 378896 NA NA NA -0.00423 0.008316 -0.02053 0.012067 0.610754 0.898233 Infectious disease Viral warts (HES) T 378957 643 378458 1.1 0.098314 0.193486 0.755 1.61 0.61137 0.898591 Eye Other disorders of eye and adnexa (HES) T 378957 430 378671 0.875 -0.13342 0.262998 0.523 1.47 0.611954 0.898901 Cardiovascular Gestational hypertensionpreeclampsia (HES and self-reported) T 378957 2534 376567 1.05 0.050561 0.099892 0.865 1.28 0.612747 0.899517 Metabolic Thyroid problem not cancer (HES and self-reported) T 378957 1330 377771 1.07 0.068487 0.13582 0.821 1.4 0.61409 0.900794 Cardiovascular Ventricular rate T 8940 NA NA NA -0.02873 0.057027 -0.14051 0.08304 0.614365 0.900794 Musculoskeletal Osteomyelitis (HES) T 378957 486 378615 0.883 -0.12428 0.247138 0.544 1.43 0.615061 0.9009 Operations and Procedures Other endoscopic removal of calculus from ureter T 378957 242 378859 0.835 -0.18085 0.359763 0.412 1.69 0.615185 0.9009 Digestive system Peritonitis (HES) T 378957 722 378379 1.1 0.092248 0.18387 0.765 1.57 0.615875 0.901363 Respiratory Bronchiectasis (HES) T 378957 1708 377393 0.938 -0.06396 0.127862 0.73 1.21 0.616922 0.902342 Operations and Procedures Operations on septum of nose T 378957 4412 374689 0.961 -0.03992 0.079885 0.822 1.12 0.617293 0.902342 ENT Acute nasopharyngitis (HES) T 378957 356 378745 1.14 0.127071 0.256052 0.687 1.88 0.619703 0.902578 Cancer Larynx throat cancer (self-reported) T 378957 289 378812 1.15 0.141319 0.284183 0.66 2.01 0.618991 0.902578 Operations and Procedures Other operations on varicose vein of leg T 378957 6971 372130 1.03 0.030515 0.06148 0.914 1.16 0.61965 0.902578 Operations and Procedures Subcutaneous injection T 378957 2578 376523 1.05 0.049001 0.098724 0.865 1.27 0.619655 0.902578 Immuno-inflammation Allergy or anaphylactic reaction to drug (HES and self-reported) T 378957 4200 374901 1.04 0.038755 0.077942 0.892 1.21 0.619028 0.902578 Immuno-inflammation Rosacea (HES and self-reported) T 378957 850 378251 0.913 -0.09132 0.183223 0.637 1.31 0.618207 0.902578 Operations and Procedures Other operations on amniotic cavity T 378957 308 378793 0.858 -0.15262 0.308198 0.469 1.57 0.620462 0.903138 Operations and Procedures Creation of artificial opening into ileum T 378957 1023 378078 1.08 0.076315 0.154439 0.797 1.46 0.621205 0.903568 Operations and Procedures Instrumental correction of deformity of spine T 378957 342 378759 0.865 -0.14489 0.294098 0.486 1.54 0.622258 0.903568 Cardiovascular Primary hypertension I270 T 378957 416 378685 0.878 -0.12985 0.263282 0.524 1.47 0.621884 0.903568 Anthropometry VAT visceral adipose tissue mass T 4051 NA NA NA -0.04245 0.086141 -0.21129 0.126385 0.622147 0.903568 Symptoms Elevated blood glucose level (HES) T 378957 625 378476 0.899 -0.10592 0.217302 0.588 1.38 0.625959 0.904984 Cancer Mal neo kidney (cancer register) T 378957 918 378183 0.918 -0.08574 0.175108 0.651 1.29 0.624387 0.904984 Operations and Procedures Operations on canthus T 378957 1131 377970 1.07 0.072132 0.147842 0.804 1.44 0.625621 0.904984 Operations and Procedures Excision of redundant skin of eyelid T 378957 1118 377983 1.07 0.072127 0.147914 0.804 1.44 0.625813 0.904984 Operations and Procedures Other large intestine T 378957 3469 375632 0.958 -0.04339 0.088864 0.804 1.14 0.625379 0.904984 Operations and Procedures Curettage of uterus T 378957 6842 372259 0.969 -0.03153 0.064446 0.854 1.1 0.624656 0.904984 Neurosciences Cranial nerve problempalsy (HES and self-reported) T 378957 1916 377185 1.06 0.055741 0.113909 0.846 1.32 0.624592 0.904984 Cardiovascular Mean carotid IMT intima medial thickness at 240 degrees T 1843 NA NA NA 0.061208 0.125737 -0.18524 0.307653 0.626403 0.904984 Biological assays Mean corpuscular haemoglobin T 367719 NA NA NA 0.004094 0.008416 -0.0124 0.020589 0.626614 0.904984 Symptoms Symptoms and signs involving emotional state (HES) T 378957 584 378517 1.1 0.099247 0.20468 0.739 1.65 0.627756 0.905173 Operations and Procedures Other periarticular division of bone T 378957 263 378838 0.848 -0.16461 0.339392 0.436 1.65 0.627668 0.905173 Respiratory FEV1 FVC ratio ever smoked only T 175212 NA NA NA -0.00594 0.01226 -0.02997 0.018086 0.627872 0.905173 Operations and Procedures Other thoracic surgery (self-reported) T 378957 1195 377906 0.928 -0.07437 0.15392 0.687 1.26 0.628974 0.906219 Operations and Procedures Rectal or colon polypectomy (self-reported) T 378957 1567 377534 1.06 0.060805 0.126173 0.83 1.36 0.629862 0.906414 Operations and Procedures Extirpation of lesion of palate T 378957 297 378804 0.856 -0.15524 0.321901 0.456 1.61 0.629631 0.906414 Respiratory CopdMappingLoose primAndSec T 244506 25872 218728 1.02 0.016771 0.034862 0.95 1.09 0.630458 0.90673 Symptoms Speech disturbances (HES) T 378957 1366 377735 0.934 -0.06856 0.143029 0.705 1.24 0.631676 0.90794 Genitourinary Benign mammary dysplasia (HES) T 378957 1624 377477 0.939 -0.06265 0.131044 0.727 1.21 0.632578 0.908179 Neurosciences Mean time to correctly identify matches T 376313 NA NA NA 0.003984 0.008333 -0.01235 0.020317 0.632596 0.908179 Medication Other drugs for obstructive airway diseases inhalants T 378957 29711 349390 0.985 -0.01483 0.03115 0.927 1.05 0.634119 0.909003 Operations and Procedures Other autograft replacement of coronary artery T 378957 496 378605 0.892 -0.11455 0.240587 0.556 1.43 0.633999 0.909003 Operations and Procedures Preparation for external beam radiotherapy T 378957 655 378446 1.09 0.090491 0.190234 0.754 1.59 0.634302 0.909003 Medication Corticosteroids for systemic use plain T 378957 6943 372158 1.03 0.029059 0.061235 0.913 1.16 0.635107 0.909615 Musculoskeletal Acquired deformities of fingers and toes (HES) T 378957 8762 370339 1.03 0.025882 0.054928 0.921 1.14 0.637501 0.910341 Summary In situ neo (cancer register) T 378957 8358 370743 0.973 -0.02707 0.057453 0.87 1.09 0.637503 0.910341 Operations and Procedures Other operations on nose T 378957 294 378807 0.859 -0.15212 0.321957 0.457 1.61 0.636571 0.910341 Operations and Procedures Harvest of random pattern flap of skin from limb T 378957 233 378868 0.844 -0.16964 0.360023 0.417 1.71 0.637497 0.910341 Medication Vitamin B T 376892 15815 361221 0.98 -0.01982 0.042051 0.903 1.06 0.637325 0.910341 Genitourinary Glomerular disorders in diseases classified elsewhere (HES) T 378957 293 378808 0.86 -0.15098 0.321989 0.457 1.62 0.639149 0.910532 Cancer Carc in situ of skin (cancer register) T 378957 1157 377944 1.07 0.068721 0.146456 0.804 1.43 0.63891 0.910532 Operations and Procedures Drainage of subdural space T 378957 236 378865 0.845 -0.16892 0.359986 0.417 1.71 0.638895 0.910532 Digestive system Noninfective hepatitis (HES and self-reported) T 378957 1195 377906 1.07 0.068021 0.144777 0.806 1.42 0.638477 0.910532 Cancer Melanoma in situ (cancer register) T 378957 1026 378075 1.07 0.072263 0.154409 0.794 1.45 0.639787 0.910589 Operations and Procedures Other graft of bone T 378957 696 378405 1.09 0.087432 0.186911 0.757 1.57 0.639945 0.910589 Summary Other obstetric conditions not elsewhere classified (HES) T 378957 1624 377477 0.94 -0.06148 0.131618 0.727 1.22 0.640434 0.910747 Summary Other diseases of the digestive system (HES) T 378957 11473 367628 0.977 -0.0228 0.049142 0.888 1.08 0.642657 0.912384 Cardiovascular Cardiac arrest (HES) T 378957 863 378238 1.08 0.077917 0.168445 0.777 1.5 0.643675 0.912384 Cardiovascular Venous surgery procedures (self-reported) T 378957 246 378855 1.15 0.142603 0.308729 0.63 2.11 0.64415 0.912384 Operations and Procedures Ercp endoscopic retrograde cholangiopancreatogram (self-reported) T 378957 341 378760 1.13 0.122058 0.264317 0.673 1.9 0.644236 0.912384 Gynaecology and Obstetrics Ever had stillbirth spontaneous miscarriage or termination T 201175 64150 137096 1.01 0.011322 0.024397 0.964 1.06 0.6426 0.912384 Operations and Procedures Other operations on pilonidal sinus T 378957 206 378895 1.17 0.158147 0.341226 0.6 2.29 0.64303 0.912384 Medication Laxatives e g Dulcolax Senokot T 374624 10818 363950 0.977 -0.02348 0.050729 0.884 1.08 0.643427 0.912384 Summary Musculoskeletal system and connective tissue (HES) T 378957 844 378257 1.08 0.077889 0.170605 0.774 1.51 0.647998 0.914 Musculoskeletal Myositis (HES) T 378957 207 378894 0.838 -0.17662 0.384714 0.394 1.78 0.646169 0.914 Genitourinary Salpingitis and oophoritis (HES) T 378957 472 378629 1.11 0.102117 0.223697 0.714 1.72 0.648033 0.914 Operations and Procedures Destruction of lesion of retina T 378957 2270 376831 0.951 -0.05028 0.109778 0.767 1.18 0.646923 0.914 Operations and Procedures Primary repair of femoral hernia T 378957 527 378574 0.898 -0.10707 0.233935 0.568 1.42 0.647161 0.914 Operations and Procedures Adjustment to length of tendon T 378957 2142 376959 0.95 -0.05166 0.11304 0.761 1.19 0.64765 0.914 Metabolic Graves disease (HES and self-reported) T 378957 476 378625 0.893 -0.11304 0.247257 0.55 1.45 0.647536 0.914 Family history Bowel cancer (family history - father) T 338597 19587 319142 1.02 0.017031 0.03741 0.945 1.09 0.648918 0.914177 Neurosciences Infection of nervous system (HES and self-reported) T 378957 529 378572 0.899 -0.10653 0.233865 0.568 1.42 0.64873 0.914177 Medication Other dermatological preparations T 378957 20932 358169 1.02 0.016466 0.036339 0.947 1.09 0.650457 0.915423 Digestive system Acute appendicitis (HES) T 378957 2629 376472 1.05 0.044499 0.098237 0.862 1.27 0.650562 0.915423 Operations and Procedures Excision of dental lesion of jaw T 378957 624 378477 1.09 0.089062 0.197016 0.743 1.61 0.651229 0.915826 Eye Disorders of lacrimal system (HES) T 378957 1950 377151 0.948 -0.05328 0.118955 0.751 1.2 0.654242 0.917681 Genitourinary Chronic renal failure (HES) T 378957 4070 375031 0.964 -0.03647 0.081608 0.822 1.13 0.654934 0.917681 Medication Other antineoplastic agents T 378957 1117 377984 1.07 0.066689 0.149376 0.798 1.43 0.655275 0.917681 Operations and Procedures Other operations on spinal cord T 378957 218 378883 1.16 0.144873 0.323972 0.613 2.18 0.654748 0.917681 Operations and Procedures Reconstruction of carotid artery T 378957 506 378595 1.1 0.09742 0.218428 0.718 1.69 0.655595 0.917681 Operations and Procedures Flap operations to relax contracture of skin T 378957 656 378445 0.911 -0.09362 0.208245 0.605 1.37 0.653039 0.917681 Operations and Procedures Re exploration of organ NOC T 378957 217 378884 1.16 0.145198 0.324001 0.613 2.18 0.654052 0.917681 Digestive system Incisional hernia (HES and self-reported) T 378957 307 378794 1.13 0.122345 0.273849 0.661 1.93 0.655047 0.917681 Medication Propulsives T 378957 1384 377717 1.06 0.05943 0.134485 0.815 1.38 0.658554 0.918547 Cancer Thyroid cancer (self-reported) T 378957 362 378739 1.12 0.11292 0.255993 0.678 1.85 0.659137 0.918547 ENT Maxillo facial surgery (self-reported) T 378957 2821 376280 0.957 -0.04364 0.098978 0.788 1.16 0.659264 0.918547 Neurosciences Motor neurone disease (HES and self-reported) T 378957 231 378870 0.853 -0.1594 0.36005 0.421 1.73 0.657968 0.918547 Digestive system Primary biliary cirrhosis (HES and self-reported) T 378957 237 378864 0.853 -0.15949 0.359924 0.421 1.73 0.657671 0.918547 Infectious disease Hepatitis c (HES and self-reported) T 378957 331 378770 0.872 -0.1364 0.306993 0.478 1.59 0.656815 0.918547 Musculoskeletal Epicondylitis (HES and self-reported) T 378957 745 378356 1.08 0.080035 0.180986 0.76 1.54 0.658334 0.918547 Biological assays Mean corpuscular haemoglobin concentration T 367715 NA NA NA 0.003745 0.008434 -0.01279 0.020276 0.657036 0.918547 Medication Anxiolytics T 378957 1664 377437 1.06 0.054219 0.1233 0.829 1.34 0.66013 0.91904 Operations and Procedures Minimal access to abdominal cavity T 378957 14863 364238 1.02 0.018646 0.042436 0.938 1.11 0.660381 0.91904 Musculoskeletal Neck probleminjury (HES and self-reported) T 378957 520 378581 0.903 -0.10247 0.233951 0.571 1.43 0.661375 0.919892 Digestive system Stomatitis and related lesions (HES) T 378957 744 378357 0.918 -0.08573 0.196281 0.625 1.35 0.66227 0.920605 Cardiovascular Aortic aneurysm and dissection (HES) T 378957 1199 377902 1.06 0.062145 0.142557 0.805 1.41 0.662889 0.920934 Cardiovascular Irregular heart beat (HES and self-reported) T 378957 1395 377706 0.941 -0.06094 0.140416 0.715 1.24 0.664296 0.922357 Operations and Procedures Other reconstruction of ligament T 378957 749 378352 0.918 -0.08511 0.196359 0.625 1.35 0.664681 0.92236 Medication Antimalarials T 378957 3446 375655 1.04 0.037283 0.086294 0.876 1.23 0.665705 0.923249 Operations and Procedures Excision reconstruction of joint T 378957 1872 377229 1.05 0.049726 0.11542 0.838 1.32 0.666596 0.923953 Cardiovascular Other nontraumatic intracranial haemorrhage (HES) T 378957 336 378765 1.12 0.111911 0.264483 0.666 1.88 0.672199 0.926568 Symptoms Unknown and unspecified causes of morbidity (HES) T 378957 14557 364544 0.982 -0.01843 0.043569 0.901 1.07 0.672245 0.926568 Operations and Procedures Anterior posterior repair bladder uterus (self-reported) T 378957 3518 375583 1.04 0.03621 0.085494 0.877 1.23 0.671904 0.926568 Operations and Procedures Lower limb surgery (self-reported) T 378957 1770 377331 0.948 -0.05354 0.125805 0.741 1.21 0.670409 0.926568 Operations and Procedures Filtering operations on iris T 378957 833 378268 1.08 0.072883 0.170756 0.77 1.5 0.669509 0.926568 Operations and Procedures Introduction of therapeutic substance into subcutaneous tissue T 378957 610 378491 0.912 -0.09227 0.217447 0.595 1.4 0.67132 0.926568 Operations and Procedures Diagnostic imaging of central nervous system T 378957 13682 365419 1.02 0.018873 0.044225 0.934 1.11 0.669555 0.926568 Gynaecology and Obstetrics Gynaecological disorder not c (HES and self-reported) T 378957 16832 362269 1.02 0.017311 0.040761 0.939 1.1 0.671071 0.926568 Gynaecology and Obstetrics Uterine fibroids (HES and self-reported) T 378957 13674 365427 1.02 0.01892 0.044733 0.934 1.11 0.672329 0.926568 Gynaecology and Obstetrics Menopausal symptoms menopause (HES and self-reported) T 378957 9705 369396 1.02 0.022366 0.052716 0.922 1.13 0.671373 0.926568 Operations and Procedures Other induction of labour T 378957 2732 376369 0.958 -0.04332 0.102684 0.783 1.17 0.673125 0.926605 Biological assays Red blood cell erythrocyte count T 367722 NA NA NA 0.003557 0.008424 -0.01295 0.020067 0.672881 0.926605 Other Pattern 3 f T 173207 46281 126998 1.01 0.01182 0.028059 0.958 1.07 0.673578 0.926699 Operations and Procedures Vacuum delivery T 378957 1205 377896 0.938 -0.06379 0.15182 0.697 1.26 0.674353 0.926706 Operations and Procedures Burrhole approach to contents of cranium T 378957 411 378690 1.11 0.101489 0.241304 0.69 1.78 0.674056 0.926706 Cancer Lung cancer (self-reported) T 378957 205 378896 0.851 -0.16148 0.384862 0.4 1.81 0.674785 0.926771 Metabolic Hyperparathyroidism (HES and self-reported) T 378957 788 378313 1.08 0.073536 0.175658 0.763 1.52 0.675486 0.927206 Cancer Skin cancer (self-reported) T 378957 1189 377912 1.06 0.059948 0.143531 0.801 1.41 0.676193 0.927647 Metabolic Thyrotoxicosis (HES) T 378957 1663 377438 0.948 -0.05336 0.128837 0.736 1.22 0.678732 0.92822 Mental health Sexual dysfunction not caused disorder or disease (HES) T 378957 264 378837 0.871 -0.13797 0.339516 0.448 1.69 0.684471 0.92822 Neurosciences Nerve root and plexus disorders (HES) T 378957 316 378785 1.12 0.112181 0.273616 0.654 1.91 0.681809 0.92822 ENT Other hearing loss (HES) T 378957 2563 376538 0.959 -0.04207 0.102976 0.784 1.17 0.682899 0.92822 Cardiovascular Sequelae of cerebrovascular disease (HES) T 378957 1161 377940 1.06 0.060171 0.146349 0.797 1.41 0.680963 0.92822 Cardiovascular Varicose veins of other sites (HES) T 378957 460 378641 0.902 -0.10358 0.254752 0.547 1.49 0.684305 0.92822 Genitourinary Inflammatory diseases of prostate (HES) T 378957 1436 377665 0.944 -0.05764 0.13949 0.718 1.24 0.67943 0.92822 Medication Agents against amoebiasis and other protozoal diseases T 378957 660 378441 0.918 -0.08512 0.20818 0.611 1.38 0.682618 0.92822 Medication Corticosteroids and antiinfectives in combination 2 T 378957 6221 372880 1.03 0.02647 0.064676 0.905 1.17 0.682342 0.92822 Cardiovascular Pacemaker defibrillator insertion (self-reported) T 378957 680 378421 0.92 -0.0829 0.204152 0.617 1.37 0.684702 0.92822 Cancer Hodgkin s disease (cancer register) T 378957 245 378856 1.14 0.128321 0.308754 0.621 2.08 0.677697 0.92822 Operations and Procedures Microsurgical repair of peripheral nerve T 378957 222 378879 1.14 0.132145 0.323858 0.605 2.15 0.68325 0.92822 Operations and Procedures Other therapeutic endoscopic operations on larynx T 378957 206 378895 0.855 -0.15686 0.384739 0.402 1.82 0.683499 0.92822 Operations and Procedures Examination of sigmoid colon T 378957 2690 376411 1.04 0.040163 0.09778 0.859 1.26 0.681256 0.92822 Operations and Procedures Forceps cephalic delivery T 378957 705 378396 1.08 0.076941 0.186088 0.75 1.56 0.679266 0.92822 Operations and Procedures Exploration of other skin of head or neck T 378957 445 378656 1.1 0.097463 0.234731 0.696 1.75 0.677987 0.92822 Operations and Procedures Release of fascia T 378957 204 378897 0.854 -0.15747 0.384847 0.402 1.82 0.682413 0.92822 Medication Glucosamine T 377706 73561 304289 0.991 -0.00876 0.021318 0.951 1.03 0.680989 0.92822 Metabolic Thyroid radioablation therapy (HES and self-reported) T 378957 2506 376595 0.959 -0.04233 0.104055 0.782 1.18 0.684155 0.92822 Metabolic Disorder of adrenal gland (HES and self-reported) T 378957 470 378631 0.903 -0.10239 0.247253 0.556 1.47 0.67878 0.92822 Gynaecology and Obstetrics Ovarian cyst or cysts (HES and self-reported) T 378957 6134 372967 0.973 -0.02763 0.066755 0.853 1.11 0.678922 0.92822 Medication Antiadrenergic agents peripherally acting T 378957 4727 374374 0.97 -0.03075 0.07585 0.836 1.13 0.685179 0.928344 Cardiovascular Carotid artery angioplasty stent (self-reported) T 378957 333 378768 0.888 -0.11867 0.294382 0.499 1.58 0.686876 0.929076 Gynaecology and Obstetrics Ovarian tubal surgery (self-reported) T 378957 1138 377963 0.939 -0.06288 0.155938 0.692 1.27 0.686786 0.929076 Summary Neo of uncertain or unknown behaviour (cancer register) T 378957 2117 376984 1.04 0.0439 0.108748 0.844 1.29 0.686445 0.929076 Cancer Carc in situ of other digestive organs (cancer register) T 378957 262 378839 1.13 0.118501 0.295806 0.63 2.01 0.688711 0.931035 Summary Congenital malformations of the urinary system (HES) T 378957 821 378280 1.07 0.068802 0.173032 0.763 1.5 0.690906 0.932955 Metabolic Other hypothyroidism (HES) T 378957 12869 366232 1.02 0.018198 0.045724 0.931 1.11 0.690639 0.932955 Gynaecology and Obstetrics Gestational hypertension without significant proteinuria (HES) T 378957 427 378674 0.903 -0.10177 0.256514 0.546 1.49 0.691562 0.933318 Digestive system Irritable bowel syndrome (HES) T 378957 5022 374079 0.971 -0.02922 0.073818 0.84 1.12 0.69218 0.933629 Musculoskeletal Other disorders of bone density and structure (HES) T 378957 998 378103 0.936 -0.06602 0.167887 0.674 1.3 0.694147 0.933668 Operations and Procedures Neurostimulation of peripheral nerve T 378957 545 378556 0.914 -0.08983 0.228082 0.585 1.43 0.6937 0.933668 NA Ischaemic stroke T 378957 3655 375446 0.966 -0.03408 0.086557 0.816 1.15 0.69378 0.933668 Genitourinary Erectile dysfunction impotence (HES and self-reported) T 378957 497 378604 0.909 -0.09487 0.240583 0.568 1.46 0.693323 0.933668 Musculoskeletal Fracture metatarsal (HES and self-reported) T 378957 436 378665 1.1 0.09245 0.23481 0.692 1.74 0.693787 0.933668 Immuno-inflammation Other follicular disorders (HES) T 378957 373 378728 1.11 0.100268 0.255788 0.67 1.83 0.695059 0.933852 Medication Decongestants and other nasal preparations for topical use T 378957 33775 345326 0.989 -0.01151 0.029345 0.933 1.05 0.694993 0.933852 Medication Hemorrhoids and anal fissures for topical use T 378957 11708 367393 1.02 0.018699 0.047852 0.928 1.12 0.695961 0.934543 Anthropometry Visceral adipose tissue volume VAT T 801 NA NA NA -0.07798 0.199962 -0.46991 0.313943 0.696545 0.934806 Medication Beta lactam antibacterials penicillins T 378957 1102 377999 1.06 0.058641 0.150896 0.789 1.43 0.697556 0.935121 Operations and Procedures Discectomy (self-reported) T 378957 1381 377720 1.05 0.052281 0.134474 0.81 1.37 0.697438 0.935121 Operations and Procedures Compensation for renal failure T 378957 703 378398 0.925 -0.07767 0.200136 0.625 1.37 0.697952 0.935131 Medication Angiotensin ii antagonists combinations T 378957 30598 348503 0.988 -0.01207 0.031154 0.929 1.05 0.698554 0.935415 Medication Other gynecologicals T 378957 52465 326636 1.01 0.009265 0.02419 0.963 1.06 0.701697 0.935415 Summary Viral infections skin and mucous memb (HES) T 378957 1422 377679 1.05 0.050935 0.133293 0.81 1.37 0.702367 0.935415 Summary Bacterial viral and other infectious agents (HES) T 378957 11829 367272 1.02 0.018151 0.047689 0.927 1.12 0.703491 0.935415 Metabolic Deficiency of other B group vitamins (HES) T 378957 664 378437 1.08 0.073999 0.193361 0.737 1.57 0.701942 0.935415 Gynaecology and Obstetrics Other maternal diseases complicating pregnancy (HES) T 378957 1582 377519 0.951 -0.05076 0.132682 0.733 1.23 0.702034 0.935415 Symptoms Localized swelling mass and lump of skin and subcutaneous tissue (HES) T 378957 1921 377180 0.955 -0.04559 0.11967 0.756 1.21 0.703256 0.935415 Symptoms Symptoms cognitive functions and awareness (HES) T 378957 2889 376212 1.04 0.035812 0.094155 0.862 1.25 0.703681 0.935415 Operations and Procedures Plastic repair of mitral valve T 378957 528 378573 1.08 0.081239 0.213561 0.714 1.65 0.703648 0.935415 Operations and Procedures Neuropsychology tests T 378957 256 378845 0.879 -0.12901 0.339556 0.452 1.71 0.703988 0.935415 Eye Eye trauma (HES and self-reported) T 378957 816 378285 1.07 0.066781 0.175496 0.758 1.51 0.703552 0.935415 Neurosciences Trigemminal neuralgia (HES and self-reported) T 378957 464 378637 0.909 -0.09553 0.247351 0.56 1.48 0.699331 0.935415 Eye Macular degeneration (HES and self-reported) T 378957 2130 376971 0.958 -0.04304 0.112573 0.768 1.19 0.702226 0.935415 Other Morning evening person chronotype T 338480 NA NA NA -0.00336 0.008821 -0.02065 0.013929 0.703201 0.935415 Cardiovascular Mean carotid IMT intima medial thickness at 210 degrees T 1850 NA NA NA -0.04795 0.123983 -0.29095 0.195061 0.698971 0.935415 Cardiovascular Other lymphatic vessels and lymph nodes (HES) T 378957 601 378500 1.08 0.075959 0.200755 0.728 1.6 0.705159 0.935711 Digestive system Other diseases of lip and oral mucosa (HES) T 378957 2606 376495 0.962 -0.03891 0.102871 0.786 1.18 0.705275 0.935711 Operations and Procedures Therapeutic endoscopic operations on uterus T 378957 6827 372274 0.976 -0.02402 0.063521 0.862 1.11 0.705376 0.935711 Genitourinary Cystic kidney disease (HES) T 378957 414 378687 1.1 0.090913 0.241262 0.683 1.76 0.706305 0.936427 Biological assays Nucleated red blood cell count T 367058 NA NA NA -0.00316 0.008418 -0.01966 0.01334 0.707388 0.937347 Musculoskeletal Fracture upper arm humerus elbow (HES and self-reported) T 378957 3361 375740 0.967 -0.03347 0.090218 0.81 1.15 0.71067 0.941179 Cardiovascular Subarachnoid haemorrhage (HES) T 378957 743 378358 1.07 0.067992 0.183752 0.747 1.53 0.711367 0.941584 Neurosciences Multiple sclerosis (HES) T 378957 1215 377886 1.05 0.052962 0.143401 0.796 1.4 0.711882 0.941653 Respiratory Postprocedural respiratory disorders (HES) T 378957 334 378767 0.898 -0.10778 0.294254 0.504 1.6 0.714155 0.941653 Gynaecology and Obstetrics Postpartum haemorrhage (HES) T 378957 1204 377897 1.05 0.053222 0.144808 0.794 1.4 0.713218 0.941653 Cancer Cervical cancer (self-reported) T 378957 1533 377568 1.05 0.0473 0.128253 0.815 1.35 0.712275 0.941653 Operations and Procedures Colonoscopy sigmoidoscopy (self-reported) T 378957 7510 371591 0.978 -0.02222 0.060548 0.869 1.1 0.713644 0.941653 Summary Had major operations T 173294 111364 62003 1.01 0.009582 0.026148 0.959 1.06 0.714041 0.941653 Operations and Procedures Other examination of female genital tract T 378957 3998 375103 0.97 -0.03043 0.083034 0.824 1.14 0.713988 0.941653 Digestive system Unspecified appendicitis (HES) T 378957 412 378689 0.908 -0.09615 0.263275 0.542 1.52 0.714958 0.942196 Medication Calcium channel blockers and diuretics T 378957 18780 360321 0.986 -0.01411 0.038961 0.913 1.06 0.71719 0.942262 Summary HESCH Pregnancy childbirth and the puerperium (HES) T 378957 12811 366290 0.98 -0.01974 0.054225 0.882 1.09 0.715883 0.942262 Operations and Procedures Closure of cornea T 378957 204 378897 0.87 -0.1397 0.384808 0.409 1.85 0.716571 0.942262 Operations and Procedures Endoscopic retrograde placement of prosthesis in bile duct T 378957 560 378541 1.08 0.075636 0.208942 0.716 1.62 0.717355 0.942262 Operations and Procedures Other operations to facilitate delivery T 378957 2119 376982 0.959 -0.04175 0.115202 0.765 1.2 0.717052 0.942262 Cardiovascular Cardiac output T 3764 NA NA NA 0.032491 0.089721 -0.14336 0.208344 0.717254 0.942262 Operations and Procedures Other operations on peripheral nerve T 378957 2062 377039 0.959 -0.04135 0.115085 0.766 1.2 0.719338 0.942938 Operations and Procedures Other vaginal operations on uterus T 378957 1552 377549 1.05 0.045384 0.126712 0.816 1.34 0.720218 0.942938 Operations and Procedures Other route of administration of therapeutic substance T 378957 241 378860 0.879 -0.12946 0.359784 0.434 1.78 0.718968 0.942938 Operations and Procedures Immobilisation using plaster cast T 378957 694 378407 1.07 0.068205 0.189962 0.738 1.55 0.71956 0.942938 Operations and Procedures Biopsy of organ NOC T 378957 7160 371941 1.02 0.021675 0.060466 0.908 1.15 0.71999 0.942938 Digestive system Colitisnot crohns or ulcerative colitis (HES and self-reported) T 378957 15433 363668 1.02 0.015101 0.041893 0.935 1.1 0.718496 0.942938 Summary Complications of labour and delivery (HES) T 378957 8512 370589 1.02 0.022282 0.062411 0.905 1.16 0.721076 0.943548 Symptoms Isolated proteinuria (HES) T 378957 277 378824 1.11 0.105238 0.295388 0.623 1.98 0.721639 0.943772 ENT Acute pharyngitis (HES) T 378957 757 378344 0.934 -0.06833 0.192818 0.64 1.36 0.723073 0.944375 Symptoms Heartburn (HES) T 378957 1828 377273 0.957 -0.04359 0.123087 0.752 1.22 0.723208 0.944375 Biological assays Nucleated red blood cell percentage T 367055 NA NA NA -0.00298 0.008418 -0.01948 0.013519 0.723276 0.944375 Operations and Procedures Other operations on haemorrhoid T 378957 276 378825 1.11 0.104383 0.29541 0.622 1.98 0.723826 0.944581 Cardiovascular Nonrheumatic mitral valve disorders (HES) T 378957 2168 376933 1.04 0.038155 0.10817 0.84 1.28 0.724286 0.94467 Musculoskeletal Cervical disc disorders (HES) T 378957 1357 377744 0.951 -0.05022 0.143024 0.719 1.26 0.725497 0.945226 Operations and Procedures Incision of iris T 378957 599 378502 1.07 0.070559 0.200831 0.724 1.59 0.725338 0.945226 Neurosciences Other polyneuropathies (HES) T 378957 1097 378004 1.05 0.05249 0.150975 0.784 1.42 0.728083 0.948082 Cardiovascular Other venouslymphatic disease (HES and self-reported) T 378957 1107 377994 0.947 -0.05467 0.15761 0.695 1.29 0.728703 0.948377 Operations and Procedures Other autograft of skin T 378957 1822 377279 1.04 0.040661 0.117643 0.827 1.31 0.729622 0.948933 Operations and Procedures Complex reconstruction of hindfoot T 378957 342 378759 1.1 0.091249 0.264309 0.653 1.84 0.729918 0.948933 Neurosciences Other demyelinating diseases of CNS (HES) T 378957 283 378818 0.897 -0.10828 0.322199 0.477 1.69 0.736813 0.949189 Respiratory Acute upper respiratory infections (HES) T 378957 729 378372 0.936 -0.06601 0.196358 0.637 1.38 0.736751 0.949189 Digestive system Other diseases of oesophagus T 378957 8938 370163 1.02 0.018504 0.054639 0.915 1.13 0.734868 0.949189 Digestive system Paralytic ileus and intestinal obstruction without hernia (HES) T 378957 3590 375511 0.971 -0.02974 0.087004 0.819 1.15 0.732494 0.949189 Immuno-inflammation Skin changes due to chronic exposure to nonionizing radiation (HES) T 378957 2179 376922 1.04 0.036742 0.107603 0.84 1.28 0.732757 0.949189 Musculoskeletal Kyphosis and lordosis (HES) T 378957 201 378900 1.12 0.114875 0.341323 0.575 2.19 0.736449 0.949189 Musculoskeletal Other bursopathies (HES) T 378957 729 378372 1.06 0.062367 0.18383 0.742 1.53 0.734408 0.949189 Genitourinary Hypertrophy of breast (HES) T 378957 719 378382 1.07 0.063987 0.186804 0.739 1.54 0.731947 0.949189 Genitourinary Dysplasia of cervix uteri (HES) T 378957 1404 377697 1.05 0.045082 0.133676 0.805 1.36 0.73593 0.949189 Cancer Uterine endometrial cancer (self-reported) T 378957 936 378165 1.06 0.055467 0.162223 0.769 1.45 0.732414 0.949189 Metabolic Thyroidectomy partial thyroidectomy (self-reported) T 378957 3577 375524 0.971 -0.02985 0.086878 0.819 1.15 0.731126 0.949189 Operations and Procedures Operations on eyebrow T 378957 613 378488 1.07 0.067739 0.200674 0.722 1.59 0.735696 0.949189 Operations and Procedures Therapeutic ureteroscopic operations on ureter T 378957 1338 377763 1.05 0.047004 0.138068 0.8 1.37 0.733522 0.949189 Operations and Procedures Denervation of spinal facet joint of vertebra T 378957 675 378426 1.07 0.064174 0.190084 0.735 1.55 0.735659 0.949189 Eye Eyeeyelid problem (HES and self-reported) T 378957 17843 361258 1.01 0.013137 0.039073 0.939 1.09 0.736715 0.949189 Musculoskeletal Fracture finger (HES and self-reported) T 378957 1578 377523 1.04 0.043068 0.127045 0.814 1.34 0.73461 0.949189 ENT Hear loss B T 120977 NA NA NA 0.004957 0.014545 -0.02355 0.033466 0.733226 0.949189 Operations and Procedures Repair of diaphragmatic hernia T 378957 276 378825 0.898 -0.10779 0.322328 0.477 1.69 0.738063 0.950291 Metabolic Thyroid radioablation therapy (self-reported) T 378957 360 378741 0.91 -0.0941 0.282759 0.523 1.58 0.739287 0.95085 ENT Chronic sinusitis (HES and self-reported) T 378957 4361 374740 0.974 -0.02628 0.078934 0.834 1.14 0.739178 0.95085 Summary Oed prot and hyprtn dis in preg chldbrth (HES) T 378957 1199 377902 0.952 -0.04965 0.151531 0.707 1.28 0.743163 0.952697 Neurosciences Other paralytic syndromes (HES) T 378957 334 378767 0.908 -0.09678 0.29422 0.51 1.62 0.742207 0.952697 Symptoms Oedema (HES) T 378957 1490 377611 0.956 -0.04449 0.135432 0.733 1.25 0.742518 0.952697 Summary Mal neo of mesothelial and soft tissue (cancer register) T 378957 538 378563 0.928 -0.075 0.228155 0.593 1.45 0.74237 0.952697 Operations and Procedures Endoscopic operations to increase capacity of bladder T 378957 1067 378034 0.948 -0.05299 0.161504 0.691 1.3 0.742829 0.952697 Operations and Procedures Other operations on penis T 378957 452 378649 1.08 0.077189 0.234862 0.682 1.71 0.742417 0.952697 Operations and Procedures Other operations on subcutaneous tissue T 378957 494 378607 0.924 -0.07866 0.240375 0.577 1.48 0.743491 0.952697 Summary Delivery (HES) T 378957 2450 376651 0.966 -0.03445 0.107352 0.783 1.19 0.748261 0.95278 Haematology Acute posthaemorrhagic anaemia (HES) T 378957 226 378875 1.11 0.103539 0.323725 0.588 2.09 0.749093 0.95278 Genitourinary Vulvovaginal ulceration and inflammation (HES) T 378957 202 378899 1.12 0.110329 0.341402 0.572 2.18 0.746571 0.95278 Genitourinary Erosion and ectropion of cervix uteri (HES) T 378957 830 378271 0.943 -0.05817 0.180933 0.662 1.35 0.747839 0.95278 Genitourinary Menopausal and other perimenopausal disorders (HES) T 378957 9413 369688 1.02 0.017315 0.053625 0.916 1.13 0.746785 0.95278 Medication Other antibacterials T 378957 1343 377758 0.955 -0.04586 0.143071 0.722 1.26 0.748576 0.95278 Operations and Procedures Achilles tendon repair (self-reported) T 378957 613 378488 0.934 -0.06813 0.212809 0.616 1.42 0.748847 0.95278 Neurosciences Neck shoulder pain for 3 months vs no pain T 344799 58990 285942 1.01 0.00743 0.02319 0.963 1.05 0.748682 0.95278 Operations and Procedures Other open operations on valve of heart T 378957 301 378800 0.905 -0.09954 0.307443 0.496 1.65 0.746123 0.95278 Operations and Procedures Diagnostic transluminal operations on coronary artery T 378957 808 378293 0.942 -0.05975 0.186415 0.654 1.36 0.748574 0.95278 Operations and Procedures Diagnostic transluminal operations on vein T 378957 931 378170 1.05 0.053187 0.163886 0.765 1.45 0.745533 0.95278 Operations and Procedures Diagnostic testing of genitourinary system T 378957 578 378523 1.07 0.067699 0.208791 0.711 1.61 0.745754 0.95278 Eye Retinal problem (HES and self-reported) T 378957 7219 371882 1.02 0.019224 0.060062 0.906 1.15 0.748918 0.95278 Biological assays White blood cell leukocyte count T 367717 NA NA NA 0.002733 0.008435 -0.0138 0.019266 0.745932 0.95278 Other Snoring T 352620 131409 221344 0.994 -0.00581 0.018225 0.959 1.03 0.74975 0.95282 Gynaecology and Obstetrics Fibrocystic disease (HES and self-reported) T 378957 1743 377358 0.961 -0.03989 0.125136 0.752 1.23 0.749916 0.95282 Medication Vitamin b12 and folic acid T 378957 8262 370839 0.982 -0.01823 0.057815 0.877 1.1 0.752531 0.953127 Medication Thyroid preparations T 378957 21493 357608 1.01 0.011406 0.036193 0.942 1.09 0.752664 0.953127 Gynaecology and Obstetrics Labour and delivery complicated by fetal stress (HES) T 378957 3031 376070 1.03 0.029822 0.094742 0.856 1.24 0.75294 0.953127 Mental health Probable recurrent major depression moderate T 58804 11697 47141 0.983 -0.01701 0.054066 0.884 1.09 0.75304 0.953127 Operations and Procedures Other therapeutic transluminal operations on coronary artery T 378957 858 378243 1.06 0.053583 0.170787 0.755 1.47 0.753718 0.953127 Operations and Procedures Prosthetic replacement of head of femur using cement T 378957 222 378879 0.893 -0.11313 0.36043 0.441 1.81 0.753616 0.953127 Respiratory Respiratory failure (HES and self-reported) T 378957 1951 377150 0.964 -0.0371 0.118243 0.764 1.21 0.753713 0.953127 Genitourinary Renalkidney failure (HES and self-reported) T 378957 8356 370745 1.02 0.017887 0.056279 0.912 1.14 0.750616 0.953127 Musculoskeletal Fracture patella knee (HES and self-reported) T 378957 515 378586 0.929 -0.07349 0.233992 0.587 1.47 0.753463 0.953127 Operations and Procedures Other operations on ventricle of brain T 378957 227 378874 0.894 -0.1125 0.360157 0.441 1.81 0.754764 0.953764 Respiratory GOLD tobin T 18298 NA NA NA -0.01153 0.036954 -0.08396 0.060898 0.755014 0.953764 Digestive system Intestinal malabsorption (HES) T 378957 1888 377213 0.964 -0.03717 0.119728 0.762 1.22 0.756216 0.954269 Genitourinary Neuromuscular dysfunction of bladder (HES) T 378957 1508 377593 1.04 0.040621 0.131059 0.806 1.35 0.756602 0.954269 Operations and Procedures Operations on frontal sinus T 378957 1944 377157 1.04 0.035805 0.115228 0.827 1.3 0.756003 0.954269 Medication Antipropulsives T 378957 2041 377060 0.965 -0.03527 0.115111 0.77 1.21 0.759299 0.954769 ENT Otosclerosis (HES) T 378957 275 378826 0.905 -0.09935 0.322356 0.481 1.7 0.757926 0.954769 Respiratory Chronic sinusitis (HES) T 378957 2225 376876 0.967 -0.03383 0.110955 0.778 1.2 0.760471 0.954769 Immuno-inflammation Urticaria (HES) T 378957 328 378773 1.09 0.084003 0.273388 0.636 1.86 0.758641 0.954769 Immuno-inflammation Follicular cysts of skin and subcutaneous tissue (HES) T 378957 7583 371518 1.02 0.018033 0.059164 0.907 1.14 0.760518 0.954769 Symptoms Malaise and fatigue (HES) T 378957 2616 376485 1.03 0.030342 0.099569 0.848 1.25 0.760565 0.954769 Digestive system Oesophageal stricture (HES and self-reported) T 378957 1781 377320 1.04 0.036804 0.119943 0.82 1.31 0.758961 0.954769 Cardiovascular Aortic aneurysm (HES and self-reported) T 378957 1220 377881 1.04 0.043481 0.142499 0.79 1.38 0.760267 0.954769 Other NumCigarettes T 111849 NA NA NA 0.004756 0.015477 -0.02558 0.035091 0.758596 0.954769 Gynaecology and Obstetrics Cervix surgery (self-reported) T 378957 1570 377531 1.04 0.038526 0.127241 0.81 1.33 0.762059 0.955469 Operations and Procedures Other therapeutic transluminal operations on heart T 378957 1372 377729 0.958 -0.04247 0.140413 0.728 1.26 0.762313 0.955469 Metabolic Parathyroid gland problem not cancer (HES and self-reported) T 378957 274 378827 1.09 0.089505 0.295471 0.613 1.95 0.761948 0.955469 Medication Digestives incl enzymes T 378957 255 378846 1.1 0.093133 0.308479 0.6 2.01 0.76272 0.955482 Summary Influenza and pneumonia (HES) T 378957 9013 370088 0.984 -0.01651 0.055066 0.883 1.1 0.7643 0.955507 Cardiovascular Occlusion and stenosis not cerebral infarction (HES) T 378957 928 378173 0.95 -0.05172 0.172778 0.677 1.33 0.764696 0.955507 Operations and Procedures Clearance of external auditory canal T 378957 325 378776 0.915 -0.08851 0.294377 0.514 1.63 0.76367 0.955507 Operations and Procedures Total excision of bone T 378957 1188 377913 0.956 -0.04497 0.150771 0.711 1.28 0.765516 0.955507 Operations and Procedures Other open operations on joint T 378957 1273 377828 0.957 -0.04363 0.145979 0.719 1.27 0.765047 0.955507 Medication Ranitidine e g Zantac T 374624 7205 367563 0.982 -0.0185 0.061906 0.869 1.11 0.765024 0.955507 Digestive system Oesophageal disorder (HES and self-reported) T 378957 9080 370021 1.02 0.016207 0.054269 0.914 1.13 0.765214 0.955507 Neurosciences Polyneuropathy in diseases classified elsewhere (HES) T 378957 353 378748 0.919 -0.08419 0.282866 0.528 1.6 0.765988 0.955601 Musculoskeletal Muscle or soft tissue injuries (HES and self-reported) T 378957 9386 369715 1.02 0.015801 0.053295 0.915 1.13 0.766861 0.956195 Medication Antifungals for topical use T 378957 3710 375391 0.975 -0.02522 0.085752 0.824 1.15 0.768705 0.957008 Respiratory Other pleural conditions (HES) T 378957 242 378859 0.905 -0.10009 0.339991 0.465 1.76 0.768452 0.957008 Cardiovascular LVESVi T 3760 NA NA NA 0.026442 0.089813 -0.14959 0.202475 0.768439 0.957008 Operations and Procedures Incision of capsule of lens T 378957 1497 377604 0.961 -0.03932 0.134397 0.739 1.25 0.76985 0.957013 Anthropometry Abdominal subcutaneous adipose tissue volume ASAT T 801 NA NA NA 0.058453 0.199835 -0.33322 0.450129 0.769901 0.957013 Biological assays Mean corpuscular volume T 367720 NA NA NA 0.002468 0.008419 -0.01403 0.01897 0.769429 0.957013 Genitourinary Renal failure not requiring dialysis (HES and self-reported) T 378957 483 378618 0.932 -0.07009 0.240482 0.582 1.49 0.770713 0.957528 Summary Other degenerative diseases of the nervous system (HES) T 378957 907 378194 1.05 0.047765 0.166135 0.757 1.45 0.773725 0.958762 Summary Dermatitis and eczema (HES) T 378957 2862 376239 0.972 -0.02792 0.097624 0.803 1.18 0.774869 0.958762 Infectious disease Zoster (HES) T 378957 425 378676 1.07 0.069363 0.241136 0.668 1.72 0.773613 0.958762 Infectious disease Viral infection of unspecified site (HES) T 378957 1590 377511 1.04 0.036272 0.126977 0.808 1.33 0.77514 0.958762 Eye Other inflammation of eyelid (HES) T 378957 538 378563 1.06 0.060959 0.213397 0.7 1.61 0.77514 0.958762 Cardiovascular Haemorrhoids (HES) T 378957 21509 357592 1.01 0.01026 0.035885 0.942 1.08 0.774943 0.958762 Eye Squint correction (self-reported) T 378957 5064 374037 0.979 -0.02099 0.073016 0.849 1.13 0.773757 0.958762 Operations and Procedures Other operations on eye T 378957 768 378333 1.05 0.05161 0.180877 0.739 1.5 0.775389 0.958762 Operations and Procedures Release of organ NOC T 378957 896 378205 0.951 -0.0499 0.175123 0.675 1.34 0.775686 0.958762 Medication Vitamin C T 376892 32744 344292 1.01 0.00855 0.029535 0.952 1.07 0.772209 0.958762 Metabolic Deficiency of other nutrient elements (HES) T 378957 216 378885 0.904 -0.10134 0.360498 0.446 1.83 0.778618 0.959796 Mental health Schizophrenia (HES) T 378957 496 378605 0.936 -0.06584 0.240328 0.585 1.5 0.784126 0.959796 Cardiovascular Hypertensive renal disease (HES) T 378957 1396 377705 1.04 0.037484 0.134569 0.798 1.35 0.780593 0.959796 Respiratory Bacterial pneumonia (HES) T 378957 433 378668 0.931 -0.07194 0.255013 0.565 1.53 0.777869 0.959796 Immuno-inflammation Rosacea (HES) T 378957 277 378824 0.914 -0.08941 0.322314 0.486 1.72 0.781475 0.959796 Musculoskeletal Other acquired deformities of limbs (HES) T 378957 1540 377561 0.964 -0.03653 0.132031 0.744 1.25 0.782045 0.959796 Genitourinary Unspecified lump in breast (HES) T 378957 1403 377698 1.04 0.037211 0.13462 0.797 1.35 0.782226 0.959796 Genitourinary Other noninflammatory disorders of vulva and perineum (HES) T 378957 1719 377382 1.03 0.034338 0.121787 0.815 1.31 0.777983 0.959796 Other Poisoning by diuretics and other drugs (HES) T 378957 335 378766 0.921 -0.0827 0.294243 0.517 1.64 0.778665 0.959796 Medication Other drugs for disorders of the musculo skeletal system T 378957 2679 376422 1.03 0.027468 0.09795 0.848 1.25 0.779149 0.959796 Mental health Single episode of probable major depression T 54605 7501 47141 0.982 -0.0178 0.064188 0.866 1.11 0.781492 0.959796 Neurosciences Stomach abdominal pain for 3 months vs no pain T 357669 17535 340271 1.01 0.010926 0.039703 0.935 1.09 0.783175 0.959796 Operations and Procedures Destruction of peripheral nerve T 378957 243 378858 0.91 -0.09379 0.339905 0.468 1.77 0.782604 0.959796 Operations and Procedures Buckling operations for attachment of retina T 378957 659 378442 0.945 -0.05701 0.204201 0.633 1.41 0.780101 0.959796 Operations and Procedures Extended excision of right hemicolon T 378957 250 378851 1.09 0.084626 0.30865 0.594 1.99 0.783945 0.959796 Operations and Procedures Early operations NOC T 378957 2989 376112 1.03 0.02541 0.092931 0.855 1.23 0.784528 0.959796 Operations and Procedures Radiopharmaceutical imaging T 378957 249 378852 0.91 -0.09385 0.339741 0.468 1.77 0.782371 0.959796 Immuno-inflammation Acneacne vulgaris (HES and self-reported) T 378957 277 378824 0.914 -0.09029 0.322336 0.486 1.72 0.77939 0.959796 Cardiovascular Aortic regurgitation incompetence (HES and self-reported) T 378957 711 378390 1.05 0.052752 0.186897 0.731 1.52 0.77775 0.959796 Musculoskeletal Fracture vertebra crush fracture vertebral col (HES and self-reported) T 378957 1036 378065 1.04 0.042599 0.156065 0.769 1.42 0.784889 0.959796 NA Adult only asthma over16yo (self-reported) T 367054 31918 335270 0.992 -0.00828 0.030154 0.935 1.05 0.783627 0.959796 Operations and Procedures Introduction of radioactive material into organ NOC T 378957 376 378725 0.928 -0.07424 0.27265 0.544 1.58 0.785405 0.959939 Operations and Procedures Other operations on ossicle of ear T 378957 327 378774 0.924 -0.07939 0.29434 0.519 1.64 0.787365 0.961847 Summary Mal neo of female genital organs (cancer register) T 378957 2734 376367 0.974 -0.02675 0.099401 0.801 1.18 0.787836 0.961935 Operations and Procedures Abdominal operations to support outlet of female bladder T 378957 1021 378080 1.04 0.042288 0.158102 0.765 1.42 0.789107 0.962998 Cardiovascular Hypotension (HES) T 378957 4415 374686 0.979 -0.02085 0.078165 0.84 1.14 0.789654 0.963046 Operations and Procedures Anal fissure surgery (self-reported) T 378957 526 378575 0.941 -0.0606 0.228235 0.602 1.47 0.790611 0.963046 Operations and Procedures Mri magnetic resonance imaging (self-reported) T 378957 522 378579 0.941 -0.0605 0.228247 0.602 1.47 0.790961 0.963046 Operations and Procedures Excision of left hemicolon T 378957 330 378771 0.925 -0.07825 0.294337 0.519 1.65 0.790355 0.963046 Operations and Procedures Operations on Bartholin gland T 378957 599 378502 1.06 0.054229 0.204775 0.707 1.58 0.791145 0.963046 ENT Conductive and sensorineural hearing loss (HES) T 378957 866 378235 0.955 -0.04612 0.177756 0.674 1.35 0.795271 0.964093 Cardiovascular Cardiomyopathy (HES) T 378957 1163 377938 0.961 -0.03962 0.152404 0.713 1.3 0.794878 0.964093 Genitourinary Acute renal failure (HES) T 378957 4117 374984 0.979 -0.02102 0.081118 0.835 1.15 0.795517 0.964093 Medication Topical products for joint and muscular pain T 378957 62133 316968 0.994 -0.00593 0.022616 0.951 1.04 0.793333 0.964093 Cardiovascular Fem pop bypass leg artery bypass (self-reported) T 378957 221 378880 0.91 -0.09438 0.360493 0.449 1.84 0.793476 0.964093 Cardiovascular Cerebral artery aneurysm surgery or clipping (self-reported) T 378957 222 378879 0.911 -0.09334 0.3603 0.45 1.85 0.79559 0.964093 ENT Throat larynx surgery incl tracheostomy (self-reported) T 378957 2251 376850 1.03 0.02818 0.107417 0.833 1.27 0.793054 0.964093 Operations and Procedures Brain surgery (self-reported) T 378957 1560 377541 1.03 0.033148 0.127966 0.804 1.33 0.795607 0.964093 Musculoskeletal Fracture jaw (HES and self-reported) T 378957 790 378311 1.05 0.046881 0.180805 0.735 1.49 0.795412 0.964093 Immuno-inflammation Hypertrophic disorders of skin (HES) T 378957 1003 378098 1.04 0.041167 0.159747 0.762 1.43 0.796639 0.964479 Operations and Procedures Excision of tendon T 378957 253 378848 1.08 0.07947 0.308517 0.591 1.98 0.796726 0.964479 Immuno-inflammation Blisteringdesquamating skin disorder (HES and self-reported) T 378957 748 378353 1.05 0.047131 0.183704 0.731 1.5 0.797519 0.964954 Infectious disease Viral agents as the cause of diseases classified to other chapters (HES) T 378957 505 378596 0.942 -0.05991 0.234156 0.595 1.49 0.798065 0.96513 Medication Peripheral vasodilators T 378957 334 378767 1.07 0.064158 0.273295 0.624 1.82 0.814398 0.9652 Summary Disorders of thyroid gland (HES) T 378957 15440 363661 0.99 -0.0103 0.042451 0.911 1.08 0.808328 0.9652 Summary Organic including symptomatic mental disorders (HES) T 378957 1447 377654 1.03 0.032531 0.132398 0.797 1.34 0.805909 0.9652 Summary Other disorders of the nervous system (HES) T 378957 3742 375359 1.02 0.020741 0.083268 0.867 1.2 0.803291 0.9652 Summary Respiratory diseases interstitium (HES) T 378957 1501 377600 0.969 -0.03146 0.134349 0.745 1.26 0.81485 0.9652 Summary Inflammatory diseases of female pelvic organs (HES) T 378957 5417 373684 1.02 0.016903 0.069796 0.887 1.17 0.808646 0.9652 Summary Congenital malformations of the nervous system (HES) T 378957 249 378852 0.918 -0.0851 0.339739 0.472 1.79 0.802213 0.9652 Summary Symptoms nervous and musculoskeletal systems (HES) T 378957 4763 374338 0.982 -0.0181 0.07517 0.848 1.14 0.809702 0.9652 Summary Symptoms cognition perception emotional state (HES) T 378957 8138 370963 1.01 0.013745 0.057263 0.906 1.13 0.810303 0.9652 Eye Conjunctivitis (HES) T 378957 221 378880 0.914 -0.0904 0.36034 0.451 1.85 0.801903 0.9652 Respiratory Nasal polyp (HES) T 378957 2942 376159 0.976 -0.0242 0.096413 0.808 1.18 0.801827 0.9652 Immuno-inflammation Other dermatitis (HES) T 378957 1379 377722 0.968 -0.03285 0.140378 0.735 1.27 0.814951 0.9652 Musculoskeletal Polyarthrosis (HES) T 378957 3571 375530 0.98 -0.02057 0.087157 0.826 1.16 0.813402 0.9652 Genitourinary Inflammatory disorders of breast (HES) T 378957 430 378671 0.939 -0.06264 0.25511 0.57 1.55 0.806036 0.9652 Gynaecology and Obstetrics Maternal care fetal abnormality and damage (HES) T 378957 238 378863 0.922 -0.08074 0.341038 0.473 1.8 0.812845 0.9652 Symptoms Abnormal involuntary movements (HES) T 378957 819 378282 0.956 -0.04519 0.183361 0.667 1.37 0.805344 0.9652 Symptoms Symptoms and signs concerning food and fluid intake (HES) T 378957 5849 373252 1.02 0.01613 0.067062 0.891 1.16 0.80993 0.9652 Gynaecology and Obstetrics Vaginal prolapse colposuspension (self-reported) T 378957 3479 375622 0.979 -0.02167 0.088467 0.823 1.16 0.8065 0.9652 Eye Retinal operation vitrectomy (self-reported) T 378957 2253 376848 0.974 -0.02651 0.109207 0.786 1.21 0.808168 0.9652 Operations and Procedures Male circumcision (self-reported) T 378957 3497 375604 1.02 0.020506 0.08753 0.86 1.21 0.814771 0.9652 Gynaecology and Obstetrics Ovarian cyst removal surgery (self-reported) T 378957 4517 374584 0.982 -0.01864 0.077352 0.843 1.14 0.809525 0.9652 Operations and Procedures Prostate biopsy (self-reported) T 378957 258 378843 0.924 -0.07943 0.323119 0.49 1.74 0.805813 0.9652 Operations and Procedures Other operations on rectum through anus T 378957 648 378453 0.952 -0.049 0.204238 0.638 1.42 0.810396 0.9652 Operations and Procedures Dilation of anal sphincter T 378957 444 378657 1.06 0.057297 0.240841 0.661 1.7 0.811955 0.9652 Operations and Procedures Urinary diversion T 378957 327 378774 1.07 0.069769 0.273464 0.627 1.83 0.798621 0.9652 Operations and Procedures Extirpation of scrotum T 378957 239 378862 1.08 0.077638 0.323468 0.573 2.04 0.810316 0.9652 Operations and Procedures Surgical induction of labour T 378957 2296 376805 0.974 -0.02592 0.110718 0.784 1.21 0.814894 0.9652 Operations and Procedures Exploration of other skin of other site T 378957 4464 374637 0.981 -0.01897 0.077855 0.842 1.14 0.807494 0.9652 Operations and Procedures Rehabilitation for musculoskeletal disorders T 378957 364 378737 1.06 0.061768 0.255964 0.644 1.76 0.809312 0.9652 Operations and Procedures Closed reduction of fracture of bone and internal fixation T 378957 2838 376263 0.976 -0.02452 0.097659 0.806 1.18 0.801789 0.9652 Operations and Procedures Prosthetic replacement of other bone using cement T 378957 559 378542 1.05 0.051737 0.208975 0.699 1.59 0.804464 0.9652 Operations and Procedures Injection of radiocontrast material T 378957 1644 377457 1.03 0.030272 0.125997 0.805 1.32 0.810132 0.9652 Operations and Procedures Radiotherapy delivery T 378957 2124 376977 0.973 -0.02778 0.111802 0.781 1.21 0.803742 0.9652 Operations and Procedures Laser therapy to organ NOC T 378957 2987 376114 0.978 -0.02231 0.094785 0.812 1.18 0.813957 0.9652 Operations and Procedures Introduction of non removable material into organ NOC T 378957 611 378490 0.95 -0.051 0.212925 0.626 1.44 0.810707 0.9652 Digestive system Hepatitis (HES and self-reported) T 378957 1662 377439 1.03 0.0312 0.125058 0.807 1.32 0.802987 0.9652 Genitourinary Urinary frequency incontinence (HES and self-reported) T 378957 11734 367367 1.01 0.011688 0.047861 0.921 1.11 0.807073 0.9652 ENT Menieres disease (HES and self-reported) T 378957 1305 377796 1.04 0.034761 0.13933 0.788 1.36 0.802981 0.9652 Musculoskeletal Plantar fascitis (HES and self-reported) T 378957 448 378653 1.06 0.057064 0.234671 0.668 1.68 0.807877 0.9652 Cardiovascular Mitral regurgitation incompetence (HES and self-reported) T 378957 2024 377077 0.973 -0.02755 0.115254 0.776 1.22 0.81109 0.9652 Other Daytime dozing sleeping narcolepsy T 377408 NA NA NA 0.00203 0.008315 -0.01427 0.018328 0.80715 0.9652 Biological assays Eosinophill percentage T 367073 NA NA NA -0.002 0.008444 -0.01855 0.014552 0.812982 0.9652 Cancer Mal neo rectosigmoid (cancer register) T 378957 343 378758 0.936 -0.06589 0.283046 0.538 1.63 0.815925 0.965879 Genitourinary Prostatitis (HES and self-reported) T 378957 1555 377546 0.97 -0.03068 0.132459 0.748 1.26 0.816852 0.966501 Gynaecology and Obstetrics Single spontaneous delivery (HES) T 378957 1836 377265 1.03 0.027535 0.119818 0.813 1.3 0.81824 0.967478 Symptoms Abnormal blood pressure reading without diagnosis (HES) T 378957 2292 376809 1.02 0.024117 0.105756 0.833 1.26 0.819613 0.967478 Operations and Procedures Fixation of retina T 378957 1034 378067 1.04 0.035198 0.154414 0.765 1.4 0.819686 0.967478 Operations and Procedures Excision of pilonidal sinus T 378957 253 378848 0.925 -0.07773 0.339738 0.475 1.8 0.819019 0.967478 Operations and Procedures Harvest of skin for graft T 378957 2280 376821 1.02 0.02425 0.105806 0.833 1.26 0.818722 0.967478 Operations and Procedures Other operations on internal nose T 378957 2843 376258 1.02 0.021803 0.096073 0.847 1.23 0.82047 0.96793 Operations and Procedures Excision of lesion of anus T 378957 2708 376393 0.978 -0.02252 0.099913 0.804 1.19 0.821676 0.968484 ENT Throat or larynx disorder (HES and self-reported) T 378957 3484 375617 0.98 -0.01995 0.08853 0.824 1.17 0.821744 0.968484 Genitourinary Other disorders of penis (HES) T 378957 1896 377205 1.03 0.026298 0.11708 0.816 1.29 0.822279 0.968641 Eye Blindness and low vision (HES) T 378957 805 378296 1.04 0.038139 0.178045 0.733 1.47 0.830386 0.971371 Respiratory Chronic rhinitis nasopharyngitis and pharyngitis (HES) T 378957 770 378331 0.96 -0.04083 0.189544 0.662 1.39 0.829428 0.971371 Respiratory Other chronic obstructive pulmonary disease (HES) T 378957 7608 371493 1.01 0.012753 0.059627 0.901 1.14 0.830645 0.971371 Digestive system Other diseases of appendix (HES) T 378957 242 378859 0.928 -0.07425 0.339915 0.477 1.81 0.827083 0.971371 Genitourinary Other congenital malformations of kidney (HES) T 378957 214 378887 0.926 -0.07715 0.360552 0.457 1.88 0.830565 0.971371 ENT Ear surgery (self-reported) T 378957 6011 373090 1.01 0.014546 0.06631 0.891 1.16 0.826369 0.971371 Operations and Procedures Total excision of colon and rectum T 378957 212 378889 1.08 0.073025 0.340854 0.552 2.1 0.830359 0.971371 Operations and Procedures Excision of bone T 378957 3651 375450 1.02 0.018185 0.084374 0.863 1.2 0.829352 0.971371 Operations and Procedures Other operations on tendon T 378957 780 378321 0.96 -0.04037 0.186449 0.666 1.38 0.828564 0.971371 Operations and Procedures Other total prosthetic replacement of hip joint T 378957 1064 378037 0.966 -0.03482 0.157848 0.709 1.32 0.825426 0.971371 Operations and Procedures Approach through thoracic cavity T 378957 602 378499 0.955 -0.0461 0.212903 0.629 1.45 0.828563 0.971371 ENT Dentures T 377502 63135 314511 0.995 -0.00514 0.023401 0.95 1.04 0.826112 0.971371 Eye Glaucoma (HES and self-reported) T 378957 6262 372839 0.986 -0.01424 0.065242 0.868 1.12 0.827164 0.971371 Neurosciences Fluid intelligence score T 184451 NA NA NA 0.002543 0.011757 -0.0205 0.025587 0.828735 0.971371 Biological assays Potassium in urine T 367300 NA NA NA -0.00182 0.008452 -0.01839 0.014743 0.829212 0.971371 Summary Noninflammatory disorders of female genital tract (HES) T 378957 43955 335146 1.01 0.005846 0.027441 0.953 1.06 0.8313 0.971665 Symptoms Signs involving the nervous and musculoskeletal systems (HES) T 378957 2611 376490 1.02 0.021051 0.099168 0.841 1.24 0.831894 0.971888 Eye Hordeolum and chalazion (HES) T 378957 1665 377436 0.973 -0.027 0.127797 0.758 1.25 0.832702 0.971889 Haematology Myeloproliferative disorder (HES and self-reported) T 378957 455 378646 1.05 0.04958 0.234689 0.663 1.66 0.832685 0.971889 Musculoskeletal Other osteochondropathies (HES) T 378957 239 378862 0.931 -0.07103 0.34003 0.478 1.81 0.834531 0.97214 Genitourinary Unspecified nephritic syndrome (HES) T 378957 244 378857 0.931 -0.07135 0.339873 0.478 1.81 0.833711 0.97214 ENT Hearing difficulty problems with background noise T 371341 140624 230856 1 0.003673 0.017558 0.97 1.04 0.834277 0.97214 Operations and Procedures Vaginal excision of uterus T 378957 4716 374385 1.02 0.015632 0.074643 0.878 1.18 0.834117 0.97214 Medication Other beta lactam antibacterials T 378957 374 378727 0.945 -0.05678 0.272697 0.554 1.61 0.835057 0.972282 Respiratory Pneumonia organism unspecified (HES) T 378957 8203 370898 0.988 -0.01182 0.057505 0.883 1.11 0.837091 0.973236 Gynaecology and Obstetrics Sterilisation (self-reported) T 378957 16084 363017 1.01 0.008549 0.041751 0.929 1.09 0.837756 0.973236 Operations and Procedures Fixation of bone of face T 378957 219 378882 1.07 0.069643 0.340675 0.55 2.09 0.838021 0.973236 Metabolic Parathyroid hyperplasiaadenoma (HES and self-reported) T 378957 419 378682 0.949 -0.05249 0.255217 0.575 1.56 0.837059 0.973236 Musculoskeletal Giant celltemporal arteritis (HES and self-reported) T 378957 395 378706 0.948 -0.05379 0.263606 0.565 1.59 0.8383 0.973236 Genitourinary Diabetic nephropathy (HES and self-reported) T 378957 242 378859 0.933 -0.06978 0.339941 0.479 1.82 0.837368 0.973236 Summary Radiation related disorders of the skin and subcutaneous tissue (HES) T 378957 2288 376813 1.02 0.021342 0.105847 0.83 1.26 0.840204 0.974276 Neurosciences Spinal muscular atrophy and related syndromes (HES) T 378957 213 378888 0.93 -0.07228 0.360644 0.459 1.89 0.841161 0.974276 Mental health Single Probable major depression episode T 91467 6104 85411 1.01 0.013443 0.066902 0.889 1.16 0.840748 0.974276 Operations and Procedures Operations on gingiva T 378957 429 378672 0.95 -0.0511 0.255051 0.576 1.57 0.841218 0.974276 Operations and Procedures Procurement of drugs for chemotherapy for neoplasm in Bands 1 5 T 378957 5730 373371 1.01 0.013499 0.067238 0.888 1.16 0.84088 0.974276 Summary Renal failure (HES) T 378957 7743 371358 1.01 0.011702 0.058561 0.902 1.13 0.841623 0.974277 Metabolic Hyperfunction of pituitary gland (HES) T 378957 291 378810 0.941 -0.06119 0.3076 0.515 1.72 0.842308 0.974601 Summary Cerebral palsy and other paralytic syndromes (HES) T 378957 2036 377065 1.02 0.020579 0.113108 0.818 1.27 0.855632 0.975807 Summary Other disorders of eye and adnexa (HES) T 378957 876 378225 1.03 0.030599 0.170483 0.738 1.44 0.857557 0.975807 Summary Noninfective enteritis and colitis (HES) T 378957 17546 361555 1.01 0.007198 0.039528 0.932 1.09 0.855513 0.975807 Summary Renal tubulo interstitial diseases (HES) T 378957 3453 375648 1.02 0.015543 0.08703 0.856 1.2 0.858257 0.975807 Summary HESCH Diseases of the digestive system (HES) T 378957 137916 241185 0.997 -0.00333 0.01754 0.963 1.03 0.849265 0.975807 Infectious disease Streptococcus and staphylococcus (HES) T 378957 3735 375366 1.02 0.015454 0.083564 0.862 1.2 0.853277 0.975807 Eye Keratitis (HES) T 378957 236 378865 1.06 0.058344 0.323379 0.562 2 0.856822 0.975807 ENT Other disorders of middle ear and mastoid (HES) T 378957 400 378701 0.951 -0.05042 0.263361 0.567 1.59 0.84818 0.975807 Cardiovascular Other cardiac arrhythmias (HES) T 378957 2381 376720 1.02 0.019923 0.104149 0.832 1.25 0.848294 0.975807 Digestive system Other noninfective gastroenteritis and colitis (HES) T 378957 14793 364308 1.01 0.007627 0.042892 0.926 1.1 0.858866 0.975807 Musculoskeletal Other specific joint derangements (HES) T 378957 2363 376738 0.98 -0.02042 0.10672 0.795 1.21 0.848255 0.975807 Musculoskeletal Osteopathies in diseases classified elsewhere (HES) T 378957 292 378809 0.942 -0.05936 0.307582 0.516 1.72 0.846971 0.975807 Symptoms Dysphagia (HES) T 378957 5765 373336 1.01 0.012907 0.067614 0.887 1.16 0.848606 0.975807 Medication Antiinfectives T 378957 956 378145 1.03 0.029394 0.163781 0.747 1.42 0.85757 0.975807 Cancer Testicular cancer (self-reported) T 378957 670 378431 1.04 0.036968 0.196958 0.705 1.53 0.851115 0.975807 Operations and Procedures Percutaneous open kidney stone surgery lithotripsy (self-reported) T 378957 2177 376924 0.979 -0.02121 0.111096 0.787 1.22 0.848623 0.975807 Operations and Procedures Bowel resection (self-reported) T 378957 706 378395 1.03 0.03411 0.189901 0.713 1.5 0.857452 0.975807 Family history Lung cancer (family history - father) T 338597 30466 308263 0.994 -0.00598 0.030917 0.936 1.06 0.84656 0.975807 Family history Prostate cancer (family history - sibling) T 301109 4736 296500 0.986 -0.01425 0.075252 0.851 1.14 0.849783 0.975807 Operations and Procedures Extirpation of lesion of peripheral nerve T 378957 1390 377711 0.975 -0.02557 0.139171 0.742 1.28 0.854233 0.975807 Operations and Procedures Extirpation of lesion of eyelid T 378957 5517 373584 0.987 -0.01284 0.069974 0.861 1.13 0.854353 0.975807 Operations and Procedures Recession of muscle of eye T 378957 270 378831 0.941 -0.06065 0.322482 0.5 1.77 0.85082 0.975807 Operations and Procedures Diagnostic fibreoptic endoscopic examination of oesophagus T 378957 1468 377633 0.976 -0.02403 0.135432 0.749 1.27 0.859148 0.975807 Operations and Procedures Therapeutic fibreoptic gastrointestinal tract T 378957 1244 377857 0.973 -0.02737 0.147545 0.729 1.3 0.852826 0.975807 Operations and Procedures Other open operations on other artery T 378957 320 378781 0.944 -0.05786 0.294472 0.53 1.68 0.844239 0.975807 Operations and Procedures Diagnostic transluminal operations on other artery T 378957 397 378704 1.05 0.045669 0.255503 0.634 1.73 0.858141 0.975807 Operations and Procedures Total excision of kidney T 378957 1063 378038 0.97 -0.03092 0.159595 0.709 1.33 0.846358 0.975807 Operations and Procedures Diagnostic endoscopic examination of ureter T 378957 1627 377474 0.977 -0.0237 0.128852 0.759 1.26 0.85409 0.975807 Operations and Procedures Therapeutic endoscopic operations on pleura T 378957 310 378791 1.06 0.053653 0.283639 0.605 1.84 0.849968 0.975807 Operations and Procedures Complex reconstruction of forefoot T 378957 800 378301 0.966 -0.03471 0.183553 0.674 1.38 0.850015 0.975807 Operations and Procedures External resuscitation T 378957 3496 375605 1.02 0.016051 0.086209 0.858 1.2 0.852297 0.975807 Operations and Procedures Cytology of organ NOC T 378957 2554 376547 0.981 -0.01926 0.102928 0.802 1.2 0.851543 0.975807 Mental health Ever unenthusiastic disinterested for a whole week T 121342 44857 76548 0.994 -0.00575 0.030485 0.937 1.06 0.85038 0.975807 Medication Zinc T 377706 15460 362390 0.993 -0.0075 0.042171 0.914 1.08 0.858865 0.975807 Metabolic Disorder or pituitary gland (HES and self-reported) T 378957 409 378692 1.05 0.047435 0.247946 0.645 1.7 0.848283 0.975807 Digestive system Duodenal ulcer (HES and self-reported) T 378957 4066 375035 1.02 0.015891 0.081068 0.867 1.19 0.844597 0.975807 Immuno-inflammation Lichen sclerosis (HES and self-reported) T 378957 542 378559 0.96 -0.04109 0.222918 0.62 1.49 0.853745 0.975807 Infectious disease Rubella german measles (HES and self-reported) T 378957 452 378649 0.957 -0.04405 0.240798 0.597 1.53 0.854847 0.975807 Cardiovascular Cardiac index during PWA T 7999 NA NA NA -0.01144 0.059948 -0.12894 0.106056 0.848633 0.975807 Haematology Vitamin B12 deficiency anaemia (HES) T 378957 809 378292 1.03 0.031107 0.178047 0.728 1.46 0.861308 0.977339 Haematology Other coagulation defects (HES) T 378957 874 378227 1.03 0.029809 0.170477 0.738 1.44 0.861193 0.977339 Summary Other and unspecified disorders of the circulatory system (HES) T 378957 4939 374162 0.987 -0.01278 0.073699 0.855 1.14 0.862279 0.977543 Cardiovascular Varicose ulcer (HES and self-reported) T 378957 232 378869 0.943 -0.05901 0.340233 0.484 1.84 0.862299 0.977543 Symptoms Nausea and vomiting (HES) T 378957 10633 368468 0.991 -0.00869 0.050798 0.897 1.1 0.86419 0.979226 Summary Visual disturbances and blindness (HES) T 378957 3428 375673 1.01 0.014786 0.087342 0.855 1.2 0.865573 0.979527 Operations and Procedures Other urological surgery (self-reported) T 378957 990 378111 0.972 -0.02814 0.16572 0.703 1.35 0.865187 0.979527 Operations and Procedures Laparoscopy (self-reported) T 378957 6734 372367 0.989 -0.01074 0.063657 0.873 1.12 0.86599 0.979527 Operations and Procedures Delivery of chemotherapy for neoplasm T 378957 7579 371522 1.01 0.009917 0.05899 0.9 1.13 0.866489 0.979527 Cardiovascular LV ejection fraction T 3764 NA NA NA 0.015104 0.089733 -0.16077 0.190979 0.866334 0.979527 Immuno-inflammation Dermatitis due to substances taken internally (HES) T 378957 436 378665 1.04 0.040154 0.240942 0.649 1.67 0.867642 0.979911 Operations and Procedures Other operations on heart T 378957 733 378368 1.03 0.031165 0.186697 0.716 1.49 0.867427 0.979911 Cardiovascular Diseases of capillaries (HES) T 378957 604 378497 0.965 -0.03516 0.212846 0.636 1.47 0.868789 0.980746 Medication Antipsoriatics for topical use T 378957 1197 377904 1.02 0.023783 0.14764 0.767 1.37 0.872026 0.981755 Operations and Procedures Total prosthetic knee joint not using cement T 378957 695 378406 1.03 0.030811 0.190054 0.711 1.5 0.871215 0.981755 Eye Ever had eye surgery T 84638 6217 78456 0.989 -0.01087 0.06688 0.868 1.13 0.870906 0.981755 Mental health Maniabipolar disordermanic depression (HES and self-reported) T 378957 1595 377506 1.02 0.020588 0.127911 0.794 1.31 0.872128 0.981755 Musculoskeletal Fracture clavicle collar bone (HES and self-reported) T 378957 1092 378009 0.975 -0.0255 0.157712 0.716 1.33 0.871549 0.981755 Eye LogMAR final left T 83932 NA NA NA -0.00281 0.017453 -0.03702 0.031394 0.8719 0.981755 Cardiovascular Cerebral aneurysm (HES and self-reported) T 378957 545 378556 1.04 0.034781 0.217897 0.676 1.59 0.873179 0.982479 Musculoskeletal Spontaneous rupture of synovium and tendon (HES) T 378957 488 378613 0.964 -0.03704 0.234263 0.609 1.53 0.874382 0.983374 Medication Other mineral supplements T 378957 878 378223 0.973 -0.02737 0.175286 0.69 1.37 0.875922 0.984442 Musculoskeletal Rheumatoid arthritis (HES and self-reported) T 378957 6232 372869 0.99 -0.01026 0.06586 0.87 1.13 0.876149 0.984442 Cardiovascular Other arterial surgery revascularisation procedures (self-reported) T 378957 268 378833 0.952 -0.0496 0.32252 0.506 1.79 0.877783 0.9849 Operations and Procedures Opening of skin T 378957 3649 375452 0.987 -0.01327 0.086046 0.834 1.17 0.877462 0.9849 Cardiovascular Cardiomyopathy (HES and self-reported) T 378957 1272 377829 0.978 -0.02227 0.144659 0.737 1.3 0.877658 0.9849 Genitourinary Cystitis (HES) T 378957 2647 376454 0.985 -0.01518 0.100966 0.808 1.2 0.880504 0.985821 Gynaecology and Obstetrics Maternal care for known or suspected malpresentation of fetus (HES) T 378957 990 378111 0.976 -0.02477 0.164038 0.707 1.35 0.879966 0.985821 Operations and Procedures Other operations on nail T 378957 396 378705 1.04 0.03825 0.255439 0.63 1.71 0.880967 0.985821 Neurosciences Chronicdegenerative neurological problem (HES and self-reported) T 378957 4087 375014 1.01 0.012176 0.08 0.865 1.18 0.879033 0.985821 Musculoskeletal Fracture skull head (HES and self-reported) T 378957 2136 376965 0.983 -0.01702 0.113026 0.788 1.23 0.880287 0.985821 Respiratory FEV1 FVC ratio ever smoked only strict T 136671 NA NA NA -0.00208 0.013909 -0.02934 0.02518 0.88106 0.985821 Operations and Procedures Extirpation of lesion of meninges of brain T 378957 289 378812 0.955 -0.04581 0.307654 0.523 1.75 0.881623 0.985993 Operations and Procedures Therapeutic endoscopic operations on ovary T 378957 717 378384 0.972 -0.02868 0.193502 0.665 1.42 0.882189 0.986094 Gynaecology and Obstetrics Abnormal smear cervix (HES and self-reported) T 378957 1903 377198 1.02 0.017191 0.11634 0.81 1.28 0.882532 0.986094 Medication Bile therapy T 378957 233 378868 0.96 -0.04111 0.340233 0.493 1.87 0.903829 0.98634 Medication Other agents acting on the renin angiotensin system T 378957 16224 362877 0.994 -0.00561 0.041561 0.917 1.08 0.892561 0.98634 Medication Antiseptics and disinfectants T 378957 239 378862 0.954 -0.04686 0.340017 0.49 1.86 0.89039 0.98634 Summary Episodic and paroxysmal disorders (HES) T 378957 12991 366110 0.994 -0.00651 0.045976 0.908 1.09 0.887481 0.98634 Summary Disorders of eyelid lacrimal system and orbit (HES) T 378957 8748 370353 0.993 -0.00752 0.055606 0.89 1.11 0.892389 0.98634 Summary Other acute lower respiratory infections (HES) T 378957 7023 372078 1.01 0.007501 0.061692 0.893 1.14 0.903225 0.98634 Summary Infections of the skin and subcutaneous tissue (HES) T 378957 9696 369405 0.993 -0.00725 0.053019 0.895 1.1 0.891307 0.98634 Metabolic Disorders of porphyrin and bilirubin metabolism (HES) T 378957 367 378734 0.967 -0.03314 0.272771 0.567 1.65 0.90331 0.98634 Neurosciences Other degenerative diseases of nervous system (HES) T 378957 567 378534 0.971 -0.02909 0.217776 0.634 1.49 0.893748 0.98634 ENT Other disorders of ear (HES) T 378957 566 378535 1.03 0.027551 0.213133 0.677 1.56 0.897148 0.98634 Cardiovascular Subsequent myocardial infarction (HES) T 378957 663 378438 1.03 0.025302 0.196975 0.697 1.51 0.897792 0.98634 Cardiovascular Endocarditis valve unspecified (HES) T 378957 363 378738 0.962 -0.03854 0.272856 0.564 1.64 0.887686 0.98634 Digestive system Ulcerative colitis (HES) T 378957 2940 376161 0.989 -0.01155 0.095533 0.82 1.19 0.903776 0.98634 Musculoskeletal Postprocedural musculoskeletal disorders (HES) T 378957 412 378689 1.03 0.030481 0.24793 0.634 1.68 0.902153 0.98634 Gynaecology and Obstetrics Obstructed labour malpresentation of fetus (HES) T 378957 382 378719 0.963 -0.03761 0.26512 0.573 1.62 0.887199 0.98634 Symptoms Other skin changes (HES) T 378957 565 378536 1.03 0.025914 0.213143 0.676 1.56 0.903232 0.98634 Symptoms Abnormal findings in specimens from female genital organs (HES) T 378957 1312 377789 1.02 0.019136 0.139568 0.775 1.34 0.890946 0.98634 Medication Sulfonamides and trimethoprim T 378957 595 378506 0.971 -0.02927 0.212914 0.64 1.47 0.890641 0.98634 Medication Hormone antagonists and related agents T 378957 2999 376102 1.01 0.01291 0.093154 0.844 1.22 0.889776 0.98634 Medication Antigout preparations T 378957 4574 374527 0.989 -0.01081 0.077135 0.85 1.15 0.888523 0.98634 Medication Chapter p Chapter X Diseases of the respiratory system BIN (HES) T 378957 9049 370052 0.993 -0.00698 0.054877 0.892 1.11 0.898762 0.98634 Operations and Procedures Umbilical hernia repair (self-reported) T 378957 3357 375744 0.988 -0.01256 0.089279 0.829 1.18 0.88811 0.98634 Operations and Procedures Anal surgery (self-reported) T 378957 2357 376744 1.01 0.013654 0.105125 0.825 1.25 0.896657 0.98634 Operations and Procedures Laparotomy nos (self-reported) T 378957 2106 376995 1.01 0.013537 0.111117 0.815 1.26 0.903035 0.98634 Operations and Procedures Inguinal hernia repair (self-reported) T 378957 5531 373570 1.01 0.009895 0.068965 0.882 1.16 0.885916 0.98634 Operations and Procedures Orchidopexy (self-reported) T 378957 293 378808 0.962 -0.03837 0.307742 0.526 1.76 0.900786 0.98634 Family history Parkinson s disease (family history - sibling) T 301109 1576 299660 1.02 0.018105 0.127286 0.793 1.31 0.886892 0.98634 Mental health Bipolar I Disorder T 91467 595 90920 0.97 -0.03087 0.213524 0.638 1.47 0.885039 0.98634 Cancer Neo of urinary organs (cancer register) T 378957 723 378378 1.03 0.027067 0.186893 0.712 1.48 0.884847 0.98634 Summary Mal neo of thyroid and other endocrine glands (cancer register) T 378957 468 378633 0.967 -0.03304 0.240613 0.604 1.55 0.890767 0.98634 Operations and Procedures Other operations on lacrimal apparatus T 378957 939 378162 0.98 -0.02071 0.168074 0.705 1.36 0.901942 0.98634 Operations and Procedures Incision of sclera T 378957 216 378885 1.05 0.044599 0.34082 0.536 2.04 0.895887 0.98634 Operations and Procedures Microtherapeutic endoscopic operations on larynx T 378957 579 378522 0.972 -0.02851 0.21762 0.634 1.49 0.895756 0.98634 Operations and Procedures Diagnostic endoscopic examination of larynx T 378957 3294 375807 0.988 -0.01206 0.090625 0.827 1.18 0.894104 0.98634 Operations and Procedures Surgical removal of tooth T 378957 5408 373693 0.991 -0.0087 0.07063 0.863 1.14 0.901937 0.98634 Operations and Procedures Emergency excision of appendix T 378957 2570 376531 1.01 0.012559 0.100971 0.831 1.23 0.901013 0.98634 Operations and Procedures Other excision of colon T 378957 242 378859 1.04 0.043561 0.323208 0.554 1.97 0.892789 0.98634 Operations and Procedures Other operations on bowel T 378957 379 378722 0.967 -0.03393 0.272561 0.567 1.65 0.900917 0.98634 Operations and Procedures Other therapeutic endoscopic operations on bladder T 378957 557 378544 1.03 0.029608 0.213329 0.678 1.56 0.889616 0.98634 Operations and Procedures Photodestruction of lesion of skin T 378957 418 378683 1.03 0.032169 0.247907 0.635 1.68 0.896755 0.98634 Operations and Procedures Transposition of tendon T 378957 795 378306 0.976 -0.02415 0.183468 0.681 1.4 0.895276 0.98634 Operations and Procedures Other operations on muscle T 378957 238 378863 0.958 -0.04261 0.340027 0.492 1.87 0.900277 0.98634 Operations and Procedures Bone and extramedullary fixation T 378957 5789 373312 1.01 0.008202 0.067581 0.883 1.15 0.903401 0.98634 Operations and Procedures Stabilising operations on joint T 378957 716 378385 0.975 -0.02489 0.193041 0.668 1.42 0.897407 0.98634 Operations and Procedures Therapeutic endoscopic operations on other articular cartilage T 378957 3095 376006 1.01 0.011603 0.091395 0.846 1.21 0.898978 0.98634 Eye Glaucoma T 124323 5306 119070 1.01 0.010216 0.070752 0.879 1.16 0.885194 0.98634 ENT Bleeding gums T 377502 49304 328342 0.996 -0.0036 0.024986 0.949 1.05 0.885353 0.98634 Neurosciences Facial pain T 378087 12842 365389 1.01 0.005903 0.046049 0.919 1.1 0.898004 0.98634 Respiratory Asthma (HES and self-reported) T 378957 48549 330552 1 0.003097 0.024888 0.955 1.05 0.900984 0.98634 Respiratory Pneumonia (HES and self-reported) T 378957 13446 365655 1.01 0.005412 0.044893 0.921 1.1 0.904043 0.98634 ENT Nasal polyps (HES and self-reported) T 378957 4016 375085 0.989 -0.01079 0.081963 0.842 1.16 0.895218 0.98634 Musculoskeletal Fracture toe (HES and self-reported) T 378957 413 378688 1.03 0.031159 0.24793 0.635 1.68 0.899987 0.98634 Medication Other analgesics and antipyretics T 378957 121055 258046 0.998 -0.00214 0.017983 0.963 1.03 0.905121 0.986954 Cancer Diffuse non Hodgkin s lymphoma (cancer register) T 378957 730 378371 1.02 0.021996 0.186758 0.709 1.47 0.906244 0.986954 Operations and Procedures Other operations on sympathetic nerve T 378957 470 378631 0.972 -0.02835 0.240575 0.607 1.56 0.906192 0.986954 Anthropometry Appendicular lean mass T 4100 NA NA NA 0.010145 0.086122 -0.15865 0.178944 0.906224 0.986954 Immuno-inflammation Pruritus (HES) T 378957 705 378396 1.02 0.022495 0.193109 0.7 1.49 0.907267 0.987621 Medication Ascorbic acid vitamin c incl combinations T 378957 6192 372909 0.993 -0.00728 0.066156 0.872 1.13 0.912368 0.987823 Medication Antiadrenergic agents centrally acting T 378957 1115 377986 1.02 0.016557 0.152513 0.754 1.37 0.91355 0.987823 Eye Visual disturbances (HES) T 378957 2695 376406 0.989 -0.01072 0.099497 0.814 1.2 0.914237 0.987823 Respiratory Peritonsillar abscess (HES) T 378957 376 378725 0.97 -0.03074 0.272661 0.568 1.65 0.910245 0.987823 Respiratory Other respiratory disorders (HES) T 378957 2907 376194 1.01 0.010178 0.094872 0.839 1.22 0.914565 0.987823 Digestive system Duodenal ulcer (HES) T 378957 2818 376283 0.989 -0.01112 0.098216 0.816 1.2 0.909825 0.987823 Digestive system Diaphragmatic hernia (HES) T 378957 24453 354648 1 0.003891 0.033985 0.939 1.07 0.908837 0.987823 Musculoskeletal Pyogenic arthritis (HES) T 378957 335 378766 0.97 -0.03028 0.28314 0.557 1.69 0.914833 0.987823 Medication Expectorants excl combinations with cough suppressants T 378957 1117 377984 0.983 -0.01719 0.155941 0.724 1.33 0.912207 0.987823 Gynaecology and Obstetrics Hysterectomy with oophorectomy (self-reported) T 378957 668 378433 1.02 0.021349 0.196978 0.694 1.5 0.913691 0.987823 Gynaecology and Obstetrics Intrauterine contraceptive device insertion removal (self-reported) T 378957 624 378477 0.978 -0.0226 0.204647 0.655 1.46 0.912074 0.987823 Operations and Procedures Excision of cervix uteri T 378957 3167 375934 0.99 -0.01002 0.091673 0.827 1.18 0.912927 0.987823 Operations and Procedures Reduction of fracture of other bone of face T 378957 686 378415 1.02 0.021042 0.196672 0.695 1.5 0.914796 0.987823 Operations and Procedures Other destruction of organ NOC T 378957 2176 376925 0.988 -0.01187 0.110415 0.796 1.23 0.914363 0.987823 Immuno-inflammation Allergy or anaphylactic reaction to food (HES and self-reported) T 378957 1833 377268 1.01 0.012876 0.11903 0.802 1.28 0.91386 0.987823 Gynaecology and Obstetrics Female infertility (HES and self-reported) T 378957 1328 377773 1.02 0.015452 0.140173 0.772 1.34 0.912225 0.987823 Cardiovascular Hypertrophic cardiomyopathy hcm hocm (HES and self-reported) T 378957 265 378836 1.04 0.034847 0.308225 0.566 1.89 0.909985 0.987823 Cardiovascular P duration T 8938 NA NA NA 0.006255 0.057058 -0.10558 0.118089 0.912705 0.987823 Gynaecology and Obstetrics Multiple gestation (HES) T 378957 258 378843 1.03 0.032816 0.309643 0.563 1.9 0.915599 0.987982 Summary Benign neo (cancer register) T 378957 784 378317 0.981 -0.01931 0.183531 0.685 1.41 0.916211 0.987982 Neurosciences Pain all over the body T 378087 5847 372384 0.993 -0.00717 0.067985 0.869 1.13 0.915994 0.987982 Symptoms Rash and other nonspecific skin eruption (HES) T 378957 1635 377466 0.987 -0.01333 0.12785 0.768 1.27 0.916948 0.988335 Operations and Procedures Harvest of flap of skin and fascia T 378957 546 378555 1.02 0.022555 0.217862 0.667 1.57 0.917542 0.988533 Respiratory Status asthmaticus (HES) T 378957 233 378868 0.966 -0.03442 0.340185 0.496 1.88 0.919402 0.988551 Gynaecology and Obstetrics Coronary angiogram (self-reported) T 378957 2517 376584 1.01 0.010367 0.10217 0.827 1.23 0.919179 0.988551 Cancer Mal neo cervix uteri (cancer register) T 378957 384 378717 0.973 -0.02715 0.263748 0.58 1.63 0.91802 0.988551 Gynaecology and Obstetrics Cervical erosion (HES and self-reported) T 378957 898 378203 0.983 -0.01723 0.170753 0.703 1.37 0.919611 0.988551 Neurosciences Number of incorrect matches in round T 93547 NA NA NA 0.00167 0.016368 -0.03041 0.033751 0.918729 0.988551 Medication Antihypertensives and diuretics in combination T 378957 1142 377959 1.01 0.014457 0.150846 0.755 1.36 0.923646 0.988791 Summary Polyneuropathies and peripheral nervous system (HES) T 378957 1669 377432 0.989 -0.01104 0.125976 0.773 1.27 0.930196 0.988791 Summary Other disorders of ear (HES) T 378957 4112 374989 0.992 -0.0079 0.080459 0.847 1.16 0.92179 0.988791 Summary Chondropathies (HES) T 378957 1094 378007 0.985 -0.01472 0.155856 0.726 1.34 0.924745 0.988791 ENT Other disorders of external ear (HES) T 378957 883 378218 0.985 -0.01504 0.172769 0.702 1.38 0.930643 0.988791 Immuno-inflammation Pilonidal cyst (HES) T 378957 452 378649 0.978 -0.0225 0.247574 0.602 1.59 0.927597 0.988791 Musculoskeletal Osteoporosis with pathological fracture (HES) T 378957 834 378267 1.02 0.016587 0.17546 0.721 1.43 0.924686 0.988791 Genitourinary Obstructive and reflux uropathy (HES) T 378957 2412 376689 0.991 -0.00933 0.105106 0.806 1.22 0.929301 0.988791 Gynaecology and Obstetrics Excessive vomiting in pregnancy (HES) T 378957 202 378899 0.965 -0.03521 0.362019 0.475 1.96 0.922523 0.988791 Operations and Procedures Testicular scrotal operation (self-reported) T 378957 2430 376671 0.99 -0.0104 0.10602 0.804 1.22 0.921888 0.988791 Cancer Follicular (cancer register) T 378957 389 378712 1.02 0.024253 0.255577 0.621 1.69 0.924399 0.988791 Cancer Carc in situ of breast (cancer register) T 378957 1900 377201 1.01 0.010787 0.11699 0.804 1.27 0.926539 0.988791 Operations and Procedures Diagnostic retrograde exam pancreatic duct T 378957 208 378893 0.969 -0.03109 0.360809 0.478 1.97 0.931327 0.988791 Operations and Procedures Diagnostic imaging of heart T 378957 1244 377857 0.987 -0.01315 0.144707 0.743 1.31 0.927608 0.988791 Operations and Procedures Diagnostic imaging of hepatobiliary system T 378957 861 378240 0.984 -0.01593 0.175274 0.698 1.39 0.927598 0.988791 Operations and Procedures Skeletal traction of bone T 378957 210 378891 0.967 -0.03379 0.360703 0.477 1.96 0.925364 0.988791 Operations and Procedures Other external fixation of bone T 378957 667 378434 0.983 -0.01747 0.200302 0.664 1.46 0.930491 0.988791 Operations and Procedures Approach to spine through back T 378957 309 378792 1.03 0.025402 0.283615 0.588 1.79 0.928632 0.988791 Medication Vitamin E T 376892 11056 365980 1 0.004685 0.049357 0.912 1.11 0.924371 0.988791 ENT Otosclerosis (HES and self-reported) T 378957 416 378685 1.02 0.023399 0.247859 0.63 1.66 0.924789 0.988791 Infectious disease Malaria (HES and self-reported) T 378957 480 378621 0.979 -0.02129 0.234334 0.618 1.55 0.927618 0.988791 Digestive system Malabsorptioncoeliac disease (HES and self-reported) T 378957 2523 376578 0.991 -0.00931 0.102448 0.81 1.21 0.927619 0.988791 Infectious disease Shingles (HES and self-reported) T 378957 734 378367 0.983 -0.017 0.189762 0.678 1.43 0.928597 0.988791 Digestive system Bowel intestinal obstruction (HES and self-reported) T 378957 3937 375164 0.993 -0.0071 0.082213 0.845 1.17 0.931205 0.988791 Neurosciences Benign neuroma (HES and self-reported) T 378957 590 378511 1.02 0.019567 0.208652 0.677 1.53 0.925285 0.988791 Musculoskeletal Fracture head neck (HES and self-reported) T 378957 2134 376967 1.01 0.009965 0.111732 0.811 1.26 0.928937 0.988791 Musculoskeletal OA under age 50 T 326966 14899 312194 1 0.003707 0.042807 0.923 1.09 0.930991 0.988791 Cardiovascular Cardiac index T 3764 NA NA NA 0.00846 0.089808 -0.16756 0.184485 0.924949 0.988791 Eye Other retinal disorders (HES) T 378957 3106 375995 0.992 -0.00777 0.091915 0.829 1.19 0.932615 0.989069 Eye Current eye infection T 85144 898 84281 0.986 -0.01442 0.171101 0.705 1.38 0.932821 0.989069 Eye Blepharitis eyelid infection (HES and self-reported) T 378957 653 378448 0.983 -0.01692 0.200416 0.664 1.46 0.932738 0.989069 Summary Atrophies affecting central nervous system (HES) T 378957 368 378733 1.02 0.022086 0.263882 0.609 1.71 0.933299 0.989141 Eye Glaucoma surgery trabeculectomy (self-reported) T 378957 535 378566 1.02 0.017795 0.218035 0.664 1.56 0.934953 0.989625 Other Chest pain or discomfort when walking uphill or hurrying T 47239 12507 34751 0.996 -0.00449 0.055227 0.893 1.11 0.935145 0.989625 Operations and Procedures Extirpation of lesion of external ear T 378957 1684 377417 0.99 -0.01011 0.125176 0.775 1.27 0.935616 0.989625 Operations and Procedures Operations on aneurysm of cerebral artery T 378957 201 378900 1.03 0.029802 0.361012 0.508 2.09 0.934209 0.989625 Operations and Procedures Other autograft of bone T 378957 1078 378023 0.987 -0.0127 0.157661 0.725 1.34 0.93581 0.989625 Genitourinary Undescended testicle (HES and self-reported) T 378957 210 378891 0.972 -0.02877 0.360858 0.479 1.97 0.936455 0.989873 Digestive system Gingivitis and periodontal diseases (HES) T 378957 766 378335 0.986 -0.0144 0.186536 0.684 1.42 0.93845 0.991547 Medication Angiotensin ii antagonists plain T 378957 16106 362995 0.997 -0.00277 0.041485 0.919 1.08 0.946694 0.99158 Summary Inflammatory diseases of the central nervous system (HES) T 378957 536 378565 0.985 -0.01555 0.222849 0.636 1.52 0.944364 0.99158 Summary HESCH Diseases of the respiratory system BIN (HES) T 378957 55412 323689 1 0.001763 0.023668 0.956 1.05 0.940612 0.99158 Infectious disease Diarrhoea presumed infectious (HES) T 378957 5076 374025 0.995 -0.0048 0.072517 0.863 1.15 0.947254 0.99158 Metabolic Postprocedural endocrine and metabolic disorders (HES) T 378957 1206 377895 0.99 -0.00959 0.147684 0.742 1.32 0.948205 0.99158 Respiratory Respiratory failure (HES) T 378957 1845 377256 0.992 -0.00837 0.119927 0.784 1.25 0.94439 0.99158 Symptoms Abdominal and pelvic pain (HES) T 378957 28298 350803 1 0.002318 0.031773 0.942 1.07 0.941855 0.99158 Medication Direct acting antivirals T 378957 823 378278 1.01 0.01333 0.177972 0.715 1.44 0.940296 0.99158 Medication Antiinfectives T 378957 4005 375096 0.994 -0.0059 0.081884 0.847 1.17 0.942565 0.99158 Operations and Procedures Elbow surgery (self-reported) T 378957 2248 376853 1.01 0.007196 0.107972 0.815 1.24 0.946863 0.99158 Operations and Procedures Bunion hallus valgus surgery (self-reported) T 378957 4996 374105 1.01 0.005282 0.072716 0.872 1.16 0.942097 0.99158 Cancer Mal neo larynx (cancer register) T 378957 224 378877 1.02 0.023292 0.340653 0.525 2 0.945489 0.99158 Cancer Mal neo corpus uteri (cancer register) T 378957 1276 377825 1.01 0.009441 0.142262 0.764 1.33 0.947091 0.99158 Operations and Procedures Operations on duct of breast T 378957 761 378340 0.986 -0.01417 0.1867 0.684 1.42 0.939497 0.99158 Operations and Procedures Extirpation of lesion of lip T 378957 1563 377538 0.992 -0.00841 0.130941 0.767 1.28 0.948772 0.99158 Operations and Procedures Primary closed reduction of traumatic dislocation of joint T 378957 775 378326 0.987 -0.01275 0.186471 0.685 1.42 0.945468 0.99158 Operations and Procedures Other operations on unspecified organ T 378957 2194 376907 1.01 0.007561 0.115471 0.804 1.26 0.947791 0.99158 Neurosciences Peripheral neuropathy (HES and self-reported) T 378957 2013 377088 1.01 0.007683 0.113824 0.806 1.26 0.946187 0.99158 Cardiovascular Lymphoedema (HES and self-reported) T 378957 527 378574 0.984 -0.01615 0.222971 0.636 1.52 0.942259 0.99158 Respiratory Respiratory infection (HES and self-reported) T 378957 9656 369445 0.996 -0.00378 0.053085 0.898 1.11 0.943265 0.99158 Musculoskeletal Tennis elbow lateral epicondylitis (HES and self-reported) T 378957 796 378305 1.01 0.012318 0.180717 0.71 1.44 0.945656 0.99158 Musculoskeletal Housemaids knee prepatellar bursitis (HES and self-reported) T 378957 300 378801 1.02 0.019566 0.294881 0.572 1.82 0.947096 0.99158 Infectious disease Scarlet fever scarlatina (HES and self-reported) T 378957 435 378666 1.02 0.016838 0.241013 0.634 1.63 0.944303 0.99158 Anthropometry Total thigh muscle volume T 758 NA NA NA -0.01302 0.202669 -0.41026 0.384206 0.948758 0.99158 Biological assays Eosinophill count T 367067 NA NA NA -0.00064 0.008442 -0.01719 0.015906 0.939498 0.99158 Anthropometry Total trunk fat T 801 NA NA NA 0.012628 0.19988 -0.37914 0.404393 0.949626 0.992042 Medication Corticosteroids combinations with antibiotics T 378957 20857 358244 0.998 -0.0022 0.036439 0.929 1.07 0.9519 0.992276 Summary Diseases of inner ear (HES) T 378957 1848 377253 1.01 0.007106 0.119001 0.798 1.27 0.952385 0.992276 Musculoskeletal Other soft tissue disorders (HES) T 378957 11219 367882 0.997 -0.00292 0.049217 0.905 1.1 0.952623 0.992276 Gynaecology and Obstetrics Uterine polypectomy uterine polyps removed (self-reported) T 378957 529 378572 1.01 0.013562 0.218214 0.661 1.55 0.950443 0.992276 Neurosciences General pain for 3 months vs no pain T 377059 4819 372384 1 0.004417 0.074371 0.868 1.16 0.952642 0.992276 Operations and Procedures Other operations on vagina T 378957 544 378557 1.01 0.012923 0.218026 0.661 1.55 0.952733 0.992276 Operations and Procedures External beam radiotherapy T 378957 1376 377725 1.01 0.008352 0.135768 0.773 1.32 0.950947 0.992276 Summary Haemolytic anaemias (HES) T 378957 276 378825 1.02 0.017747 0.308009 0.557 1.86 0.954052 0.992791 Cancer Mal neo other connect soft tissue (cancer register) T 378957 247 378854 1.02 0.018777 0.323058 0.541 1.92 0.953652 0.992791 Operations and Procedures Endoscopy gastroscopy (self-reported) T 378957 7551 371550 0.997 -0.00331 0.059884 0.886 1.12 0.955905 0.99429 Medication Antiinf and antiseptics excl comb with cortico T 378957 8523 370578 1 0.002648 0.056327 0.898 1.12 0.9625 0.994359 Summary Other diseases of the respiratory system (HES) T 378957 4856 374245 1 0.003297 0.073937 0.868 1.16 0.96443 0.994359 Summary Abnormal findings of urine without diagnosis (HES) T 378957 652 378449 1.01 0.010688 0.2004 0.682 1.5 0.957467 0.994359 Respiratory Unspecified acute lower respiratory infection (HES) T 378957 6878 372223 1 0.002737 0.062457 0.887 1.13 0.965052 0.994359 Symptoms Shock (HES) T 378957 252 378849 0.985 -0.01478 0.322948 0.523 1.86 0.963489 0.994359 Medication Magnetic resonance imaging contrast media T 378957 1522 377579 0.994 -0.00582 0.132108 0.767 1.29 0.964851 0.994359 Operations and Procedures Urethral surgery (self-reported) T 378957 686 378415 0.99 -0.00986 0.196611 0.674 1.46 0.960001 0.994359 Operations and Procedures Pilonidal sinus surgery anal (self-reported) T 378957 2174 376927 1.01 0.005972 0.110476 0.81 1.25 0.95689 0.994359 Cardiovascular Echocardiogram transoesophageal echo (self-reported) T 378957 455 378646 1.01 0.010594 0.240795 0.63 1.62 0.964907 0.994359 Family history Severe depression (family history - sibling) T 301109 21287 279949 1 0.001967 0.036446 0.933 1.08 0.956951 0.994359 Operations and Procedures Repair of obstetric laceration T 378957 3617 375484 0.996 -0.00418 0.088757 0.837 1.19 0.962419 0.994359 Operations and Procedures Rehabilitation for other disorders T 378957 724 378377 0.992 -0.00833 0.189858 0.684 1.44 0.965008 0.994359 Operations and Procedures High cost neurology drugs T 378957 1209 377892 0.993 -0.00694 0.147589 0.744 1.33 0.962502 0.994359 Operations and Procedures High cost ophthalmology drugs T 378957 346 378755 1.01 0.013399 0.273177 0.593 1.73 0.96088 0.994359 ENT Painful gums T 377502 10716 366930 1 0.002375 0.050212 0.908 1.11 0.962276 0.994359 Medication Iron T 377706 11432 366418 1 0.00239 0.048689 0.911 1.1 0.960845 0.994359 Neurosciences Psychologicalpsychiatric prob (HES and self-reported) T 378957 2225 376876 1 0.004828 0.109137 0.811 1.24 0.964712 0.994359 Cardiovascular Sick sinus syndrome (HES and self-reported) T 378957 373 378728 0.988 -0.01198 0.263854 0.589 1.66 0.963799 0.994359 Genitourinary Cystitis (HES and self-reported) T 378957 2918 376183 0.995 -0.00506 0.095627 0.825 1.2 0.957763 0.994359 Musculoskeletal Fracture foot (HES and self-reported) T 378957 1193 377908 0.993 -0.00669 0.14911 0.742 1.33 0.964196 0.994359 Anthropometry Total lean mass T 4100 NA NA NA 0.003895 0.086175 -0.16501 0.172797 0.963952 0.994359 Eye Corneal hysteresis right T 81141 NA NA NA -0.00082 0.017724 -0.03556 0.03392 0.963124 0.994359 Summary Papulosquamous disorders (HES) T 378957 2604 376497 0.996 -0.00428 0.10141 0.816 1.21 0.966351 0.994377 Medication Aminoglycoside antibacterials T 378957 622 378479 1.01 0.008528 0.204404 0.676 1.51 0.966721 0.994377 Medication Antiinfectives T 378957 1041 378060 0.993 -0.00684 0.159626 0.726 1.36 0.965818 0.994377 Eye Eyelid surgery (self-reported) T 378957 269 378832 1.01 0.012972 0.308099 0.554 1.85 0.966416 0.994377 Operations and Procedures Excision of rectum T 378957 2290 376811 1 0.004267 0.106882 0.814 1.24 0.968155 0.995427 Summary HESCH Diseases of the ear and mastoid process (HES) T 378957 8809 370292 0.998 -0.00202 0.055265 0.896 1.11 0.97078 0.995576 Respiratory Other disorders of nose and nasal sinuses (HES) T 378957 5991 373110 1 0.002467 0.067155 0.879 1.14 0.970692 0.995576 Symptoms Other general symptoms and signs (HES) T 378957 358 378743 0.99 -0.01024 0.272887 0.58 1.69 0.970071 0.995576 Operations and Procedures Breath tests T 378957 412 378689 0.99 -0.00967 0.255248 0.601 1.63 0.969793 0.995576 Operations and Procedures Harvest of bone T 378957 1453 377648 1 0.004922 0.134314 0.772 1.31 0.970767 0.995576 Gynaecology and Obstetrics Cervical intraepithelial neoplasia cin precan (HES and self-reported) T 378957 1670 377431 0.995 -0.00476 0.125368 0.778 1.27 0.969696 0.995576 Symptoms Other abnormal findings in urine (HES) T 378957 297 378804 1.01 0.010076 0.294931 0.567 1.8 0.972747 0.996745 ENT Nasal polyp surgery nasal polypectomy (self-reported) T 378957 1137 377964 1.01 0.005179 0.150877 0.748 1.35 0.972617 0.996745 Operations and Procedures Vasectomy (self-reported) T 378957 9426 369675 1 0.001711 0.054668 0.9 1.12 0.97503 0.997565 Operations and Procedures Other diagnostic imaging of vascular system T 378957 2957 376144 0.997 -0.00296 0.094059 0.829 1.2 0.974927 0.997565 Operations and Procedures Diaphyseal division of bone T 378957 396 378705 0.992 -0.00809 0.255565 0.601 1.64 0.974749 0.997565 Operations and Procedures Other intravenous injection T 378957 5047 374054 0.998 -0.00226 0.072731 0.865 1.15 0.975204 0.997565 Gynaecology and Obstetrics Maternal care for related to pregnancy (HES) T 378957 1641 377460 1 0.003788 0.128065 0.781 1.29 0.976404 0.998104 Symptoms Gangrene (HES) T 378957 510 378591 0.993 -0.00662 0.228402 0.635 1.55 0.97686 0.998104 Operations and Procedures Drainage through perineal region T 378957 1052 378049 1 0.004607 0.159648 0.735 1.37 0.976978 0.998104 Digestive system Hiatus hernia (HES and self-reported) T 378957 27678 351423 1 0.000911 0.032146 0.94 1.07 0.977388 0.998104 Operations and Procedures Other excision of skin T 378957 205 378896 1.01 0.009782 0.360872 0.498 2.05 0.978375 0.998689 Medication Intestinal antiinflammatory agents T 378957 25513 353588 1 0.00072 0.033174 0.938 1.07 0.982676 0.999046 Medication I v solution additives T 378957 936 378165 0.997 -0.00309 0.168112 0.717 1.39 0.985322 0.999046 Medication Cardiac glycosides T 378957 1042 378059 0.998 -0.00194 0.158089 0.732 1.36 0.990194 0.999046 Medication Corticosteroids plain T 378957 34978 344123 1 0.000432 0.02875 0.946 1.06 0.988015 0.999046 Summary Disorders of choroid and retina (HES) T 378957 6755 372346 1 -0.0005 0.062572 0.884 1.13 0.993655 0.999046 Summary Diseases of appendix (HES) T 378957 3245 375856 0.999 -0.00066 0.090279 0.837 1.19 0.994192 0.999046 Summary HESCH Congen malfor deform and chrom abnormalities (HES) T 378957 4981 374120 0.999 -0.00076 0.073033 0.866 1.15 0.991672 0.999046 Mental health Bipolar affective disorder (HES) T 378957 888 378213 0.998 -0.00175 0.172729 0.712 1.4 0.991899 0.999046 Neurosciences Other headache syndromes (HES) T 378957 459 378642 0.996 -0.0044 0.240677 0.621 1.6 0.985423 0.999046 Neurosciences Other diseases of spinal cord (HES) T 378957 528 378573 1.01 0.005799 0.222933 0.65 1.56 0.979248 0.999046 Neurosciences Other disorders of CNS (HES) T 378957 223 378878 1.01 0.006038 0.340478 0.516 1.96 0.985852 0.999046 Respiratory Other diseases of upper respiratory tract (HES) T 378957 650 378451 1 0.002444 0.20042 0.677 1.48 0.990269 0.999046 Operations and Procedures Incisional hernia repair (self-reported) T 378957 1461 377640 0.997 -0.0026 0.134342 0.767 1.3 0.984569 0.999046 Operations and Procedures Shoulder surgery (self-reported) T 378957 5679 373422 0.999 -0.0011 0.068317 0.874 1.14 0.987117 0.999046 Gynaecology and Obstetrics Pelvic floor surgery (self-reported) T 378957 271 378830 1.01 0.007805 0.308189 0.551 1.84 0.979795 0.999046 Operations and Procedures Removal of malignant melanoma (self-reported) T 378957 716 378385 0.998 -0.00161 0.189868 0.688 1.45 0.993229 0.999046 Cancer Mal neo thyroid gland (cancer register) T 378957 431 378670 0.996 -0.00387 0.247711 0.613 1.62 0.987523 0.999046 Cancer Benign neoplasm of meninges (cancer register) T 378957 350 378751 0.994 -0.00614 0.273033 0.582 1.7 0.982054 0.999046 Operations and Procedures Excision of parathyroid gland T 378957 695 378406 0.996 -0.00433 0.193221 0.682 1.45 0.982123 0.999046 Operations and Procedures Drainage of middle ear T 378957 1751 377350 0.998 -0.00221 0.123162 0.784 1.27 0.985709 0.999046 Operations and Procedures Operations on unspecified nasal sinus T 378957 717 378384 1 0.002253 0.193043 0.687 1.46 0.990689 0.999046 Operations and Procedures Surgery on apex of tooth T 378957 1147 377954 1 0.003271 0.152392 0.744 1.35 0.982877 0.999046 Operations and Procedures Extirpation of lesion of tongue T 378957 690 378411 0.996 -0.00385 0.196577 0.678 1.46 0.984389 0.999046 Operations and Procedures Other operations on scrotum T 378957 203 378898 1.01 0.007423 0.361088 0.496 2.04 0.983599 0.999046 Operations and Procedures Biopsy of cervix uteri T 378957 1749 377352 1 0.001411 0.122625 0.787 1.27 0.990822 0.999046 Operations and Procedures Other open operations on bone T 378957 605 378496 1 0.002241 0.208544 0.666 1.51 0.991427 0.999046 Operations and Procedures Harvest of other tissue T 378957 784 378317 1 0.004346 0.183525 0.701 1.44 0.981108 0.999046 Medication Vitamin A T 376892 7193 369843 1 0.000422 0.060985 0.888 1.13 0.994484 0.999046 Medication Selenium T 377706 9070 368780 1 0.000621 0.054299 0.9 1.11 0.990871 0.999046 Cardiovascular Subdural haemorrhagehaematoma (HES and self-reported) T 378957 380 378721 0.997 -0.00258 0.263736 0.595 1.67 0.992195 0.999046 Metabolic Hypothyroidismmyxoedema (HES and self-reported) T 378957 22541 356560 1 0.000279 0.035547 0.933 1.07 0.993744 0.999046 Eye Eye infection (HES and self-reported) T 378957 2800 376301 1 0.001864 0.097243 0.828 1.21 0.984711 0.999046 Immuno-inflammation Allergyhypersensitivityanaph (HES and self-reported) T 378957 3101 376000 0.998 -0.0015 0.09281 0.832 1.2 0.98709 0.999046 Immuno-inflammation Hayfeverallergic rhinitis (HES and self-reported) T 378957 22257 356844 1 -0.00032 0.035386 0.933 1.07 0.992811 0.999046 Musculoskeletal Burns (HES and self-reported) T 378957 765 378336 1 0.001869 0.186544 0.695 1.44 0.992008 0.999046 Immuno-inflammation Chronic fatigue syndrome (HES and self-reported) T 378957 1921 377180 0.997 -0.00273 0.11744 0.792 1.26 0.98146 0.999046 Infectious disease Infectious mononucleosis glandular fever epste (HES and self-reported) T 378957 517 378584 0.996 -0.00366 0.223039 0.644 1.54 0.98691 0.999046 Musculoskeletal Fracture nose (HES and self-reported) T 378957 1043 378058 0.997 -0.00259 0.159672 0.729 1.36 0.987038 0.999046 Summary Other maternal disorders predominantly related to pregnancy (HES) T 378957 2789 376312 1 -0.00038 0.100212 0.821 1.22 0.996992 0.999181 Summary Complications predominantly related to the puerperium (HES) T 378957 557 378544 1 0.000905 0.21503 0.657 1.53 0.996643 0.999181 Immuno-inflammation Seborrhoeic keratosis (HES) T 378957 2813 376288 1 -0.00031 0.096898 0.827 1.21 0.997472 0.999181 Genitourinary Calculus of lower urinary tract (HES) T 378957 726 378375 1 -0.00039 0.189963 0.689 1.45 0.998351 0.999181 Family history Parkinson s disease (family history - mother) T 354043 5725 348456 1 -0.0002 0.067791 0.875 1.14 0.997615 0.999181 Operations and Procedures Other internal fixation of bone T 378957 5999 373102 1 0.000225 0.066589 0.878 1.14 0.997307 0.999181 Operations and Procedures Diagnostic endoscopic examination of other joint T 378957 560 378541 0.999 -0.00067 0.217764 0.652 1.53 0.997554 0.999181 Operations and Procedures Other methods of operation on organ NOC T 378957 1830 377271 1 -0.00038 0.120615 0.789 1.27 0.997494 0.999181 Musculoskeletal BIN combinedFractures T 378957 28020 351081 1 -7.67E-05 0.031812 0.939 1.06 0.998076 0.999181 Musculoskeletal Fracture pelvis (HES and self-reported) T 378957 555 378546 1 0.0003 0.217799 0.653 1.53 0.998903 0.999318 Summary Demyelinating diseases of the central nervous system (HES) T 378957 1406 377695 1 2.26E-05 0.136707 0.765 1.31 0.999868 0.999868 Ordered by FDR. The category "Summary" indicates cases were anyone with admission for any code in the block. * Lung function measures described as "strict" only include individuals with passed-QC spirometry (see reference 16 in the main manuscript). Strict measures were not included in Figure 1. Table S3. Phenome-wide association study results for SERPINA1 Z allele homozygosity in UK Biobank

Category Phenotype Effect alleleN Cases Controls OR Beta SE L95 U95 P FDR Respiratory Alpha1 antitrypsin deficiency (HES and self-reported) T 379101 223 378878 293 5.67848 0.260676 175 488 3.32E-105 7.90E-102 Metabolic Other metabolic disorders (HES) T 379101 309 378792 194 5.27007 0.262003 116 325 5.50E-90 6.55E-87 Respiratory Emphysema (HES and self-reported) T 379101 1662 377439 52.5 3.96133 0.240719 32.8 84.2 7.56E-61 6.00E-58 Respiratory Emphysema (HES) T 379101 1571 377530 52.5 3.96161 0.245029 32.5 84.9 8.49E-59 5.06E-56 Respiratory Chronic obstructive airways disease (COPD) (HES and self-reported) T 379101 8796 370305 13.3 2.59138 0.219958 8.67 20.5 4.87E-32 2.32E-29 Respiratory Emphysemachronic bronchitis (HES and self-reported) T 379101 6338 372763 13.9 2.62844 0.226642 8.88 21.6 4.25E-31 1.69E-28 Respiratory COPDMappingStrict* T 190073 16733 173340 13.2 2.57861 0.24978 8.08 21.5 5.52E-25 1.88E-22 Respiratory COPDMappingLoose* primAndSec T 244600 25872 218728 8.81 2.17549 0.221711 5.7 13.6 9.97E-23 2.97E-20 Respiratory FEV1 FVC ratio ever smoked only T 175269 NA NA NA -1.1089 0.132374 -1.36835 -0.849447 5.43E-17 1.44E-14 Respiratory FEV1 FVC ratio ever smoked only strict T 136716 NA NA NA -1.15924 0.148963 -1.45121 -0.867273 7.14E-15 1.70E-12 Summary Chronic lower respiratory diseases (HES) T 379101 30351 348750 4.36 1.47141 0.190988 3 6.33 1.32E-14 2.85E-12 Respiratory FEV1 FVC ratio strict T 221665 NA NA NA -0.836435 0.111045 -1.05408 -0.618787 4.98E-14 9.88E-12 Respiratory FEV1 FVC ratio T 286167 NA NA NA -0.706768 0.098487 -0.899803 -0.513733 7.17E-13 1.31E-10 Respiratory Other chronic obstructive pulmonary disease (HES) T 379101 7608 371493 7.23 1.97863 0.276163 4.21 12.4 7.79E-13 1.33E-10 Medication Other drugs for obstructive airway diseases inhalants T 379101 29711 349390 3.6 1.27976 0.199137 2.43 5.31 1.31E-10 2.07E-08 Family history Chronic bronchitis emphysema (family history - sibling) T 301029 8228 292801 5.67 1.73432 0.272396 3.32 9.66 1.93E-10 2.87E-08 Biological assays Haemoglobin concentration T 367863 NA NA NA 0.518894 0.084205 0.353852 0.683936 7.17E-10 1.00E-07 Respiratory FEV1 percent pred T 285936 NA NA NA -0.599807 0.098453 -0.792774 -0.40684 1.11E-09 1.47E-07 Respiratory FEV1 percent pred strict T 221665 NA NA NA -0.651361 0.11101 -0.868941 -0.433781 4.42E-09 5.54E-07 Summary HESCH Diseases of the respiratory system BIN (HES) T 379101 55412 323689 2.85 1.04713 0.180357 2 4.06 6.40E-09 7.62E-07 Medication Adrenergics inhalants T 379101 26289 352812 3.35 1.2098 0.211356 2.22 5.07 1.04E-08 1.18E-06 Respiratory Other respiratory problems (HES and self-reported) T 379101 5684 373417 5.63 1.72865 0.31691 3.03 10.5 4.91E-08 5.31E-06 Biological assays Haematocrit percentage T 367863 NA NA NA 0.455851 0.084203 0.290814 0.620888 6.17E-08 6.39E-06 Respiratory Bring up phlegm sputum mucus on most days T 95696 8125 87571 5.99 1.78964 0.337325 3.09 11.6 1.12E-07 1.11E-05 Respiratory FEV1 ever smoked only T 175269 NA NA NA -0.700005 0.132125 -0.95897 -0.44104 1.17E-07 1.11E-05 Other Wheeze or whistling in the chest in last year T 371979 77179 294800 2.49 0.913788 0.174916 1.77 3.51 1.75E-07 1.60E-05 Respiratory Bronchiectasis (HES and self-reported) T 379101 2109 376992 8.57 2.14808 0.421477 3.75 19.6 3.46E-07 3.05E-05 Respiratory PEF maximumValue T 286167 NA NA NA -0.494363 0.09839 -0.687207 -0.301519 5.05E-07 4.29E-05 Medication Decongestants and other nasal preparations for topical use T 379101 33775 345326 2.75 1.0132 0.205968 1.84 4.12 8.69E-07 7.13E-05 Operations and Procedures Diagnostic imaging of chest T 379101 2157 376944 7.82 2.05652 0.420494 3.43 17.8 1.00E-06 7.97E-05 Respiratory PEF maximumValue strict T 221665 NA NA NA -0.532893 0.110972 -0.750398 -0.315388 1.57E-06 0.000121 Respiratory Cough on most days T 95696 13048 82648 4.65 1.53701 0.321706 2.48 8.74 1.77E-06 0.000132 Respiratory Bronchiectasis (HES) T 379101 1708 377393 8.78 2.17191 0.459648 3.56 21.6 2.30E-06 0.000166 Medication Corticosteroids plain T 379101 34978 344123 2.64 0.970822 0.205862 1.76 3.95 2.41E-06 0.000169 Respiratory Respiratory disorders in diseases classified elsewhere (HES) T 379101 201 378900 28.2 3.33759 0.717081 6.9 115 3.25E-06 0.000221 Respiratory Pleurisy (HES and self-reported) T 379101 1687 377414 8.21 2.10541 0.456218 3.36 20.1 3.93E-06 0.00026 Haematology Other diseases of blood and blood forming organs (HES) T 379101 563 378538 14.8 2.69252 0.586526 4.68 46.6 4.42E-06 0.000277 Eye Optic neuritis (HES and self-reported) T 379101 206 378895 26.9 3.29319 0.716627 6.61 110 4.32E-06 0.000277 Respiratory FEV1 maximumValue T 286167 NA NA NA -0.449168 0.098291 -0.641819 -0.256517 4.88E-06 0.000298 Respiratory FEV1 ever smoked only strict T 136716 NA NA NA -0.663217 0.148727 -0.954722 -0.371712 8.22E-06 0.000489 Operations and Procedures Ureteric surgery (self-reported) T 379101 604 378497 13.4 2.59432 0.58543 4.25 42.2 9.36E-06 0.000544 Medication Adrenergics for systemic use T 379101 22332 356769 2.83 1.04028 0.236892 1.78 4.5 1.13E-05 0.000639 Respiratory FEV1 maximumValue strict T 221665 NA NA NA -0.469259 0.110836 -0.686498 -0.25202 2.30E-05 0.001272 Anthropometry Standing height T 378247 NA NA NA 0.344496 0.082736 0.182334 0.506658 3.13E-05 0.001694 Biological assays Red blood cell erythrocyte count T 367863 NA NA NA 0.337645 0.084064 0.17288 0.50241 5.91E-05 0.003125 Biological assays Mean sphered cell volume T 361769 NA NA NA 0.337383 0.08503 0.170725 0.504041 7.25E-05 0.003754 Digestive system Pancreatitis (HES and self-reported) T 379101 2304 376797 6.07 1.80395 0.456482 2.48 14.9 7.76E-05 0.003929 Digestive system Pancreatic disease (HES and self-reported) T 379101 2413 376688 5.79 1.75608 0.456633 2.37 14.2 0.00012 0.005891 Respiratory Pneumonia (HES and self-reported) T 379101 13446 365655 2.98 1.09042 0.283694 1.71 5.19 0.000121 0.005891 Summary Other diseases of the respiratory system (HES) T 379101 4856 374245 4.1 1.41056 0.390923 1.9 8.82 0.000308 0.013848 Cardiovascular Other disorders of veins (HES) T 379101 415 378686 13.2 2.58366 0.715184 3.26 53.8 0.000303 0.013848 Digestive system Acute pancreatitis (HES) T 379101 1763 377338 6.29 1.83819 0.508416 2.32 17 0.0003 0.013848 Haematology Polycythaemia vera (HES and self-reported) T 379101 393 378708 13.3 2.58713 0.716571 3.26 54.1 0.000306 0.013848 Biological assays Platelet count T 367861 NA NA NA -0.295484 0.084168 -0.460453 -0.130515 0.000447 0.019709 Biological assays Platelet crit T 367858 NA NA NA -0.290828 0.08416 -0.455782 -0.125874 0.000549 0.023766 Respiratory Other respiratory disorders (HES) T 379101 2907 376194 4.8 1.56886 0.457732 1.96 11.8 0.000609 0.025207 Respiratory Respiratory failure (HES and self-reported) T 379101 1951 377150 5.79 1.75557 0.511366 2.12 15.8 0.000597 0.025207 Respiratory Spontaneous pneumothoraxrecurrent pneumothorax (HES and self-reported) T 379101 1034 378067 7.46 2.00949 0.586653 2.36 23.6 0.000614 0.025207 Haematology Myeloproliferative disorder (HES and self-reported) T 379101 455 378646 11.6 2.44788 0.716259 2.84 47.1 0.000632 0.025495 Medication Intestinal antiinflammatory agents T 379101 25513 353588 2.28 0.822325 0.241521 1.42 3.65 0.000662 0.026278 Respiratory Asthma (HES and self-reported) T 379101 48549 330552 1.96 0.671757 0.200967 1.32 2.9 0.00083 0.032393 Operations and Procedures Excision of lesion of organ NOC T 379101 2108 376993 5.35 1.67746 0.507981 1.98 14.5 0.000959 0.036254 Cardiovascular Cerebral aneurysm (HES and self-reported) T 379101 545 378556 10.6 2.35938 0.714364 2.61 42.9 0.000957 0.036254 Summary Metabolic disorders (HES) T 379101 39911 339190 2.07 0.729215 0.221517 1.34 3.2 0.000995 0.036633 Respiratory GOLD tobin T 18309 NA NA NA 0.989849 0.300819 0.400244 1.57945 0.001 0.036633 Operations and Procedures High cost neurology drugs T 379101 1209 377892 6.77 1.91178 0.584733 2.15 21.3 0.001077 0.038869 Medication Calcium T 379101 6050 373051 3.62 1.28717 0.394623 1.67 7.85 0.001107 0.039348 Respiratory Pneumonia organism unspecified (HES) T 379101 8203 370898 3.09 1.12732 0.34749 1.56 6.1 0.001178 0.041245 Cancer Large bowel cancer colorectal cancer (self-reported) T 379101 526 378575 10 2.30443 0.716816 2.46 40.8 0.001305 0.045041 Cardiovascular Congenital malformations of cardiac septa (HES) T 379101 521 378580 9.81 2.28345 0.713913 2.42 39.8 0.001381 0.04699 Cardiovascular Other cerebrovascular diseases (HES) T 379101 2188 376913 5.09 1.62658 0.510896 1.87 13.8 0.001454 0.048747 Cardiovascular Mitral valve prolapse (HES and self-reported) T 379101 545 378556 9.68 2.26977 0.714999 2.38 39.3 0.001501 0.049635 Medication Antacids T 379101 6182 372919 3.45 1.23713 0.392166 1.6 7.43 0.001607 0.052421 Other Birth weight T 215536 NA NA NA -0.335143 0.108465 -0.547734 -0.122552 0.002002 0.064426 Immuno-inflammation Chronic skin ulcers (HES and self-reported) T 379101 1331 377770 6.08 1.80545 0.586385 1.93 19.2 0.002077 0.065949 Cardiovascular High cholesterol (HES and self-reported) T 379101 62396 316705 0.362 -1.01528 0.334083 0.188 0.697 0.002374 0.074361 Summary Other diseases of pleura (HES) T 379101 6040 373061 3.21 1.16713 0.391468 1.49 6.92 0.002869 0.088574 Respiratory FEV1 FVC ratio never smoked only strict T 84281 NA NA NA -0.495945 0.166538 -0.822359 -0.169531 0.002902 0.088574 Summary Influenza and pneumonia (HES) T 379101 9013 370088 2.8 1.03013 0.34725 1.42 5.53 0.003012 0.090748 Operations and Procedures Extirpation of nail bed T 379101 679 378422 8.29 2.11473 0.713772 2.05 33.6 0.003049 0.090748 Summary Diseases of male genital organs (HES) T 379101 17819 361282 2.39 0.873052 0.296203 1.34 4.28 0.003204 0.094174 Summary Deforming dorsopathies (HES) T 379101 2539 376562 4.42 1.48584 0.509335 1.63 12 0.003532 0.102547 Summary Disorders of gallbladder biliary tract and pancreas (HES) T 379101 16365 362736 2.34 0.850561 0.292807 1.32 4.16 0.003674 0.105403 Digestive system Liver failurecirrhosis (HES and self-reported) T 379101 1525 377576 5.45 1.69614 0.585817 1.73 17.2 0.003787 0.107355 Medication Other systemic drugs for obstructive airway diseases T 379101 21417 357684 2.15 0.766109 0.265836 1.28 3.62 0.003953 0.108185 Operations and Procedures Diagnostic imaging procedures T 379101 15463 363638 2.32 0.843638 0.292428 1.31 4.12 0.003915 0.108185 Musculoskeletal BMD Combined T 338180 NA NA NA -0.249095 0.086357 -0.418354 -0.079836 0.003921 0.108185 Cardiovascular Subarachnoid haemorrhage (HES) T 379101 743 378358 7.78 2.05099 0.71369 1.92 31.5 0.004056 0.108504 Medication Macrolides lincosamides and streptogramins T 379101 736 378365 7.77 2.05078 0.71354 1.92 31.5 0.004052 0.108504 Operations and Procedures Debridement and irrigation of joint T 379101 1526 377575 5.27 1.66135 0.584383 1.68 16.6 0.00447 0.117026 Respiratory COPDExacerbation GOLD2orHigher T 8831 486 8345 8.05 2.08542 0.734492 1.91 34 0.004522 0.117026 Respiratory COPDExacerbation NI HES SPIROMETRY T 25110 2309 22801 3.25 1.17872 0.415011 1.44 7.33 0.004508 0.117026 Medication Anti acne preparations for topical use T 379101 1608 377493 5.16 1.64149 0.58425 1.64 16.2 0.004961 0.124573 Operations and Procedures Radiology with contrast T 379101 12447 366654 2.43 0.886668 0.315659 1.31 4.51 0.00497 0.124573 Operations and Procedures Radiology procedures T 379101 30410 348691 1.95 0.669682 0.237946 1.23 3.11 0.004886 0.124573 Biological assays Monocyte percentage T 367213 NA NA NA 0.235485 0.084526 0.069815 0.401155 0.005337 0.132363 Digestive system Fibrosis and cirrhosis of liver (HES) T 379101 756 378345 7.27 1.98376 0.714078 1.79 29.5 0.005468 0.134227 Operations and Procedures Removal of malignant melanoma (self-reported) T 379101 716 378385 7.24 1.97986 0.713946 1.79 29.3 0.005552 0.134894 Genitourinary Bph benign prostatic hypertrophy (HES and self-reported) T 379101 10618 368483 2.67 0.981941 0.354562 1.33 5.35 0.005615 0.135047 Symptoms Abnormalities of gait and mobility (HES) T 379101 1676 377425 5.01 1.61153 0.58581 1.59 15.8 0.005942 0.141488 Operations and Procedures Excision of haemorrhoid T 379101 2721 376380 4.01 1.38943 0.507919 1.48 10.9 0.006228 0.143964 Cardiovascular Pulmonary embolism dvt (HES and self-reported) T 379101 5241 373860 3.14 1.14562 0.418416 1.38 7.14 0.006182 0.143964 Biological assays High light scatter reticulocyte percentage T 361769 NA NA NA -0.233033 0.085075 -0.39978 -0.066286 0.00616 0.143964 Operations and Procedures Other operations on conjunctiva T 379101 712 378389 7.06 1.95397 0.71641 1.73 28.7 0.006383 0.146124 Respiratory Pneumothorax (HES) T 379101 762 378339 6.86 1.92556 0.714609 1.69 27.8 0.007048 0.159825 Genitourinary Other disorders of male genital organs (HES) T 379101 2588 376513 3.96 1.37536 0.515269 1.44 10.9 0.007603 0.170781 Biological assays Lymphocyte count T 367207 NA NA NA -0.221457 0.084475 -0.387027 -0.055887 0.008752 0.194759 Operations and Procedures Inguinal femoral hernia repair (self-reported) T 379101 12611 366490 2.33 0.844571 0.323548 1.23 4.39 0.009045 0.199412 Immuno-inflammation Decubitus ulcer (HES) T 379101 840 378261 6.37 1.85141 0.715541 1.57 25.9 0.009669 0.209298 Musculoskeletal Kyphosis and lordosis (HES) T 379101 201 378900 13.5 2.60571 1.00687 1.88 97.4 0.009656 0.209298 Respiratory Respiratory failure (HES) T 379101 1845 377256 4.54 1.51347 0.587404 1.44 14.4 0.009979 0.214063 Operations and Procedures Diagnostic imaging of hepatobiliary system T 379101 861 378240 6.21 1.82572 0.713551 1.53 25.1 0.010508 0.223395 NA Pediatric asthma under16yo (self-reported) T 350577 15307 335270 2.17 0.776859 0.30488 1.2 3.95 0.010832 0.228235 Cardiovascular Subarachnoid haemorrhage (HES and self-reported) T 379101 936 378165 6.06 1.80223 0.71331 1.5 24.5 0.011518 0.240567 Symptoms Voice disturbances (HES) T 379101 934 378167 6.03 1.79672 0.713908 1.49 24.4 0.011844 0.245231 Cardiovascular Atrial fibrillation (HES and self-reported) T 379101 2928 376173 3.62 1.28638 0.512621 1.33 9.89 0.012093 0.248225 Operations and Procedures Release of fascia T 379101 204 378897 12.3 2.51273 1.00666 1.72 88.7 0.012557 0.255536 Haematology Acute posthaemorrhagic anaemia (HES) T 379101 226 378875 12 2.48906 1.00674 1.68 86.7 0.013421 0.270815 NA Subarachnoid haemorrhage T 379101 982 378119 5.8 1.75793 0.713351 1.43 23.5 0.013727 0.274655 Medication Blood glucose lowering drugs excl insulins T 379101 49513 329588 0.426 -0.854162 0.35093 0.214 0.847 0.014933 0.28219 Summary Diseases of liver (HES) T 379101 4603 374498 3.04 1.11156 0.456502 1.24 7.44 0.014894 0.28219 Operations and Procedures Incision of eyelid T 379101 241 378860 11.6 2.45288 1.0064 1.62 83.5 0.014798 0.28219 Operations and Procedures Diagnostic microendoscopic examination of larynx T 379101 246 378855 11.7 2.46335 1.00757 1.63 84.6 0.014492 0.28219 Operations and Procedures Diagnostic echocardiography T 379101 8855 370246 2.45 0.898065 0.367569 1.19 5.05 0.014556 0.28219 Respiratory Pneumothorax (HES and self-reported) T 379101 906 378195 5.69 1.73951 0.714283 1.4 23.1 0.014878 0.28219 Biological assays Reticulocyte percentage T 361768 NA NA NA -0.208663 0.085114 -0.375487 -0.041839 0.014224 0.28219 Operations and Procedures Incision of sclera T 379101 216 378885 11.6 2.45135 1.00848 1.61 83.8 0.015069 0.282507 Other DIED T 379101 10919 368182 2.34 0.849427 0.350112 1.18 4.64 0.01526 0.283852 Genitourinary Hyperplasia of prostate (HES) T 379101 10244 368857 2.44 0.891336 0.369212 1.18 5.03 0.015772 0.291104 Neurosciences Back pain for 3 months vs no pain T 341531 65312 276219 0.494 -0.704411 0.29296 0.278 0.878 0.016196 0.296643 Genitourinary Prostate problem not cancer (HES and self-reported) T 379101 11913 367188 2.33 0.847397 0.353098 1.17 4.66 0.0164 0.298079 Digestive system Other diseases of pancreas (HES) T 379101 1002 378099 5.44 1.69393 0.713639 1.34 22 0.017613 0.306861 Immuno-inflammation Ulcer of lower limb (HES) T 379101 989 378112 5.45 1.69496 0.715154 1.34 22.1 0.017785 0.306861 Family history Chronic bronchitis emphysema (family history - mother) T 357529 20553 336976 1.96 0.671889 0.282553 1.13 3.41 0.01741 0.306861 Operations and Procedures Other operations on peripheral nerve T 379101 2062 377039 4 1.38601 0.584192 1.27 12.6 0.017667 0.306861 Operations and Procedures Secondary open reduction of fracture of bone T 379101 1013 378088 5.49 1.70272 0.713669 1.36 22.2 0.017039 0.306861 Operations and Procedures Harvest of random pattern flap of skin from limb T 379101 233 378868 10.9 2.38973 1.0073 1.52 78.6 0.017672 0.306861 Eye LogMAR final right T 84003 NA NA NA -0.400333 0.168893 -0.731363 -0.069303 0.017772 0.306861 Infectious disease Bacterial agents as the cause of diseases (HES) T 379101 7935 371166 2.51 0.920608 0.389321 1.17 5.39 0.018047 0.309136 Immuno-inflammation Nail disorders (HES) T 379101 1050 378051 5.33 1.67291 0.713216 1.32 21.6 0.018997 0.32079 NA Adult only asthma over16yo (self-reported) T 367188 31918 335270 1.79 0.583046 0.248518 1.1 2.92 0.018972 0.32079 Summary HESCH Certain infectious and parasitic diseases BIN (HES) T 379101 26714 352387 1.83 0.603365 0.259367 1.1 3.04 0.020003 0.330736 Operations and Procedures Percutaneous examination of bile duct T 379101 260 378841 10.4 2.34286 1.00659 1.45 74.9 0.019937 0.330736 Cardiovascular Cholesterol lowering medication T 376222 64923 311299 0.507 -0.67952 0.291517 0.286 0.897 0.019755 0.330736 Operations and Procedures Plastic operations on cornea T 379101 258 378843 10.3 2.33678 1.006 1.44 74.3 0.020188 0.331498 Neurosciences Parkinson s disease (HES) T 379101 1054 378047 5.25 1.65783 0.71687 1.29 21.4 0.020745 0.332122 Respiratory Pleural effusion (HES) T 379101 4725 374376 2.89 1.06222 0.458139 1.18 7.1 0.020419 0.332122 Cardiovascular Varicose vein surgery (self-reported) T 379101 15382 363719 2.08 0.732684 0.316653 1.12 3.87 0.020677 0.332122 Operations and Procedures Extirpation of scrotum T 379101 239 378862 10.3 2.33475 1.00989 1.43 74.7 0.020784 0.332122 Operations and Procedures Recession of muscle of eye T 379101 270 378831 10.2 2.32123 1.0059 1.42 73.2 0.021021 0.333667 Medication Lipid modifying agents combinations T 379101 72923 306178 0.54 -0.616855 0.268589 0.319 0.914 0.021639 0.341205 Operations and Procedures Other diagnostic tests T 379101 994 378107 5.08 1.62578 0.714074 1.25 20.6 0.0228 0.357155 Summary Symptoms and signs involving the skin and subcutaneous tissue (HES) T 379101 6510 372591 2.56 0.941261 0.417373 1.13 5.81 0.024121 0.366279 Cardiovascular Nonrheumatic mitral valve disorders (HES) T 379101 2168 376933 3.75 1.32291 0.586669 1.19 11.9 0.024137 0.366279 Digestive system Other diseases of jaws (HES) T 379101 301 378800 9.7 2.27191 1.00577 1.35 69.6 0.023892 0.366279 ENT Dental tooth surgery (self-reported) T 379101 999 378102 4.99 1.60748 0.71365 1.23 20.2 0.024292 0.366279 Operations and Procedures Operations on canthus T 379101 1131 377970 5.02 1.61357 0.713849 1.24 20.3 0.023798 0.366279 Respiratory Pleural effusion (HES and self-reported) T 379101 4887 374214 2.81 1.03192 0.458172 1.14 6.89 0.024306 0.366279 Mental health Mental and behavioural disorders due to use of alcohol (HES) T 379101 4907 374194 2.81 1.03424 0.460887 1.14 6.94 0.024831 0.366955 Operations and Procedures Excision of gall bladder T 379101 12079 367022 2.18 0.77793 0.346656 1.1 4.29 0.024826 0.366955 Operations and Procedures Revisional decompression operations on lumbar spine T 379101 287 378814 9.54 2.25594 1.00626 1.33 68.6 0.024967 0.366955 Musculoskeletal Bursitis (HES and self-reported) T 379101 2169 376932 3.71 1.31186 0.584149 1.18 11.7 0.024719 0.366955 Operations and Procedures Harvest of other multiple tissue T 379101 281 378820 9.47 2.24849 1.00681 1.32 68.2 0.025531 0.372233 Musculoskeletal Scoliosis (HES and self-reported) T 379101 1135 377966 4.93 1.5954 0.7149 1.21 20 0.025639 0.372233 Cardiovascular Other venouslymphatic disease (HES and self-reported) T 379101 1107 377994 4.9 1.58949 0.713202 1.21 19.8 0.025836 0.372816 Operations and Procedures Removal of epididymal cyst (self-reported) T 379101 269 378832 9.28 2.22828 1.00716 1.29 66.8 0.026937 0.38594 Biological assays High light scatter reticulocyte count T 361768 NA NA NA -0.188124 0.085104 -0.354928 -0.02132 0.027069 0.38594 Summary Congenital malformations of the circulatory system (HES) T 379101 1083 378018 4.83 1.57402 0.712897 1.19 19.5 0.02725 0.386205 Respiratory Pyothorax (HES) T 379101 288 378813 9.01 2.19815 1.00651 1.25 64.8 0.028967 0.407326 Operations and Procedures Anaesthetic without surgery T 379101 299 378802 8.99 2.19586 1.00618 1.25 64.6 0.029083 0.407326 Summary Diseases of arteries arterioles and capillaries (HES) T 379101 6751 372350 2.51 0.918419 0.421749 1.1 5.73 0.029433 0.409819 Operations and Procedures Liver surgery (self-reported) T 379101 301 378800 8.86 2.18191 1.00581 1.23 63.6 0.030059 0.416105 Operations and Procedures Therapeutic endoscopic operations on pleura T 379101 310 378791 8.8 2.17437 1.00652 1.22 63.3 0.030751 0.423219 Respiratory Empyema (HES and self-reported) T 379101 299 378802 8.73 2.16647 1.00641 1.21 62.7 0.031345 0.428925 Digestive system Incisional hernia (HES and self-reported) T 379101 307 378794 8.69 2.16257 1.00593 1.21 62.4 0.03157 0.429531 Metabolic Disorders of lipoprotein metabolism and other lipidaemias (HES) T 379101 32636 346465 0.374 -0.984125 0.45975 0.152 0.92 0.032309 0.435566 Operations and Procedures Gallstones removed (self-reported) T 379101 315 378786 8.61 2.15332 1.00743 1.2 62 0.032562 0.435566 Mental health Postnatal depression (HES and self-reported) T 379101 311 378790 8.68 2.16119 1.01061 1.2 62.9 0.032477 0.435566 Neurosciences Parkinsons disease (HES and self-reported) T 379101 1191 377910 4.61 1.52717 0.716688 1.13 18.8 0.0331 0.440285 Respiratory Unspecified acute lower respiratory infection (HES) T 379101 6878 372223 2.44 0.890133 0.418963 1.07 5.54 0.033619 0.440342 Operations and Procedures External resuscitation T 379101 3496 375605 2.98 1.09119 0.513711 1.09 8.15 0.033659 0.440342 Other Alcohol dependency (HES and self-reported) T 379101 5185 373916 2.67 0.980374 0.460919 1.08 6.58 0.03342 0.440342 Operations and Procedures Examination of oesophagus T 379101 1296 377805 4.5 1.50464 0.714182 1.11 18.3 0.035134 0.457129 Family history Chronic bronchitis emphysema (family history) T 379101 NA NA NA 0.174729 0.083176 0.011703 0.337755 0.035667 0.461543 Medication Antipsoriatics for topical use T 379101 1197 377904 4.42 1.48526 0.713443 1.09 17.9 0.037358 0.473287 Cancer Skin cancer (self-reported) T 379101 1189 377912 4.43 1.48877 0.714906 1.09 18 0.037299 0.473287 Cardiovascular Leg claudication intermittent claudication (HES and self-reported) T 379101 2468 376633 3.43 1.23195 0.590667 1.08 10.9 0.037006 0.473287 Other Pack years T 110918 NA NA NA -0.406884 0.195458 -0.789982 -0.023786 0.03737 0.473287 Summary Other acute lower respiratory infections (HES) T 379101 7023 372078 2.38 0.86796 0.418913 1.05 5.41 0.038271 0.479601 Cardiovascular Aortic aneurysm and dissection (HES) T 379101 1199 377902 4.46 1.49575 0.721875 1.08 18.4 0.038262 0.479601 Operations and Procedures Other operations on blood vessel T 379101 317 378784 8 2.07943 1.00733 1.11 57.6 0.038989 0.486041 Neurosciences Alzheimer s disease (HES) T 379101 359 378742 7.94 2.07186 1.01005 1.1 57.5 0.040243 0.496675 Cardiovascular Endocarditis valve unspecified (HES) T 379101 363 378738 7.88 2.06459 1.00659 1.1 56.7 0.04026 0.496675 Family history Heart disease (family history - father) T 343592 109130 234462 0.657 -0.419799 0.205104 0.44 0.982 0.040681 0.49673 Cardiovascular Aortic aneurysm (HES and self-reported) T 379101 1220 377881 4.38 1.47773 0.721841 1.06 18 0.040641 0.49673 Summary HESCH Endocrine nutritional and metabolic diseases BIN (HES) T 379101 66768 312333 1.51 0.410243 0.200979 1.02 2.23 0.041228 0.500838 Operations and Procedures Partial excision of liver T 379101 334 378767 7.75 2.04763 1.00633 1.08 55.7 0.041877 0.503578 Metabolic Thyroid problem not cancer (HES and self-reported) T 379101 1330 377771 4.29 1.45545 0.715232 1.06 17.4 0.041857 0.503578 Digestive system Peptic ulcer site unspecified (HES) T 379101 370 378731 7.66 2.03622 1.00834 1.06 55.3 0.043448 0.519843 Operations and Procedures Other excision of appendix T 379101 1270 377831 4.21 1.43746 0.712959 1.04 17 0.04378 0.5212 Summary Suppurative and necrotic conditions of lower respiratory tract (HES) T 379101 346 378755 7.57 2.0246 1.00617 1.05 54.4 0.044201 0.523478 Digestive system Cholelithiasis (HES) T 379101 12988 366113 2.01 0.696427 0.346448 1.02 3.96 0.044411 0.523478 Eye Iridocyclitis (HES) T 379101 333 378768 7.52 2.01754 1.00555 1.05 54 0.044814 0.525627 Symptoms Haemorrhage from respiratory passages (HES) T 379101 4000 375101 2.77 1.02015 0.509545 1.02 7.53 0.045276 0.528443 Operations and Procedures Introduction of radioactive material into organ NOC T 379101 376 378725 7.37 1.99709 1.00619 1.03 52.9 0.047167 0.547825 Operations and Procedures Intramuscular injection T 379101 1308 377793 4.09 1.40818 0.713571 1.01 16.6 0.048448 0.559972 Anthropometry Body mass index BMI T 377835 NA NA NA -0.163861 0.083277 -0.327085 -0.000637 0.049107 0.564854 Operations and Procedures Diagnostic transluminal operations on other artery T 379101 397 378704 7.19 1.97307 1.00722 0.999 51.8 0.050122 0.573756 Musculoskeletal Other disorders of bone (HES) T 379101 1394 377707 4.02 1.39212 0.712929 0.995 16.3 0.050858 0.574356 Family history Bowel cancer (family history - mother) T 354181 17920 336261 1.8 0.590492 0.302769 0.997 3.27 0.051139 0.574356 Other Chest pain or discomfort walking normally T 58732 10166 48566 2.21 0.791538 0.406274 0.995 4.89 0.051381 0.574356 Operations and Procedures Transluminal operations on pulmonary artery T 379101 411 378690 7.17 1.96962 1.01069 0.989 52 0.05132 0.574356 Operations and Procedures Diagnostic blood tests T 379101 378 378723 7.09 1.95915 1.00549 0.988 50.9 0.05136 0.574356 Operations and Procedures Puncture of pleura T 379101 2582 376519 3.12 1.13685 0.585572 0.989 9.82 0.052206 0.580856 Musculoskeletal Osteoporosis (HES and self-reported) T 379101 10107 368994 2.16 0.768221 0.397743 0.989 4.7 0.053428 0.588939 Biological assays Mean reticulocyte volume T 361768 NA NA NA 0.164472 0.085075 -0.002275 0.331219 0.053204 0.588939 Neurosciences Hemiplegia (HES) T 379101 1363 377738 3.95 1.3746 0.713631 0.976 16 0.05408 0.590999 Musculoskeletal Other soft tissue disorders (HES) T 379101 11219 367882 2.02 0.702055 0.364524 0.988 4.12 0.054111 0.590999 Operations and Procedures Minimal access to other body cavity T 379101 8899 370202 2.11 0.745559 0.387898 0.985 4.51 0.0546 0.593619 Summary Disorders of optic nerve and visual pathways (HES) T 379101 383 378718 6.83 1.92095 1.00541 0.952 49 0.056053 0.603903 Cancer Follicular (cancer register) T 379101 389 378712 6.84 1.92331 1.00562 0.953 49.1 0.055804 0.603903 Summary Other diseases of blood and blood forming organs (HES) T 379101 4191 374910 2.63 0.966133 0.507985 0.971 7.11 0.057185 0.605758 Summary Cerebrovascular diseases (HES) T 379101 7435 371666 2.23 0.802797 0.421082 0.978 5.09 0.056584 0.605758 Symptoms Senility (HES) T 379101 414 378687 6.8 1.91623 1.00777 0.943 49 0.057243 0.605758 ENT Nasal polyps (HES and self-reported) T 379101 4016 375085 2.63 0.967908 0.508906 0.971 7.14 0.057179 0.605758 Metabolic Other nontoxic goitre (HES) T 379101 1508 377593 3.86 1.35103 0.714707 0.951 15.7 0.058715 0.617831 Operations and Procedures Operations on gingiva T 379101 429 378672 6.68 1.89923 1.00546 0.931 47.9 0.058903 0.617831 Symptoms Ascites (HES) T 379101 1446 377655 3.8 1.33473 0.713333 0.939 15.4 0.061329 0.637662 Digestive system Liverbiliarypancreas problem (HES and self-reported) T 379101 4283 374818 2.59 0.951177 0.508218 0.956 7.01 0.061263 0.637662 Infectious disease Zoster (HES) T 379101 425 378676 6.55 1.87905 1.00584 0.912 47 0.061742 0.63916 Biological assays Immature reticulocyte fraction T 361768 NA NA NA -0.158043 0.084985 -0.324614 0.008528 0.062935 0.648694 Operations and Procedures Incision of capsule of lens T 379101 1497 377604 3.75 1.32261 0.715894 0.923 15.3 0.064675 0.660909 Mental health Ever unenthusiastic disinterested for a whole week T 121405 44857 76548 0.583 -0.539354 0.291694 0.329 1.03 0.064452 0.660909 Medication Corticosteroids combinations with antibiotics T 379101 20857 358244 1.71 0.536403 0.291184 0.966 3.03 0.065454 0.666006 Operations and Procedures Image controlled operations on abdominal cavity T 379101 419 378682 6.34 1.84663 1.00527 0.884 45.5 0.066217 0.670905 Digestive system Unspecified appendicitis (HES) T 379101 412 378689 6.26 1.8336 1.00541 0.872 44.9 0.068192 0.682461 Medication Hormone antagonists and related agents T 379101 2999 376102 2.93 1.07612 0.589661 0.923 9.32 0.068004 0.682461 Medication Vitamin B T 377036 15815 361221 0.164 -1.80782 0.992391 0.0234 1.15 0.068504 0.682461 Infectious disease Whooping cough pertussis (HES and self-reported) T 379101 415 378686 6.25 1.83319 1.00581 0.871 44.9 0.068365 0.682461 Musculoskeletal Soft tissue disorders related to use overuse and pressure (HES) T 379101 1500 377601 3.63 1.28852 0.712902 0.897 14.7 0.070696 0.695564 Digestive system Bile duct disease (HES and self-reported) T 379101 13856 365245 1.87 0.625991 0.3463 0.949 3.69 0.070661 0.695564 Cardiovascular Primary hypertension I270 T 379101 416 378685 6.18 1.82191 1.00683 0.859 44.5 0.070366 0.695564 Family history High blood pressure (family history - father) T 343592 74698 268894 0.649 -0.431596 0.239398 0.406 1.04 0.071414 0.698221 Operations and Procedures Diagnostic endoscopic examination of lower bowel T 379101 29456 349645 0.44 -0.820414 0.455291 0.18 1.07 0.071552 0.698221 ENT Nasalsinus disorder (HES and self-reported) T 379101 11324 367777 1.93 0.656002 0.364601 0.943 3.94 0.071982 0.699548 Cardiovascular Other aneurysm (HES) T 379101 436 378665 6.09 1.80716 1.00664 0.847 43.8 0.072616 0.702843 Mental health Overall health rating T 377441 NA NA NA 0.149492 0.083363 -0.0139 0.312884 0.072931 0.703031 Musculoskeletal Fractured broken bones in last 5 years T 377028 36458 340570 1.54 0.430829 0.24123 0.959 2.47 0.074105 0.70316 Operations and Procedures Other operations on sympathetic nerve T 379101 470 378631 6.04 1.79767 1.00501 0.842 43.3 0.073663 0.70316 Operations and Procedures Other operations on maxillary antrum T 379101 2872 376229 2.85 1.04613 0.584105 0.906 8.94 0.073295 0.70316 Digestive system Gall bladder disease (HES and self-reported) T 379101 13958 365143 1.86 0.618528 0.346352 0.941 3.66 0.074126 0.70316 Summary Disorders of sclera cornea iris and ciliary body (HES) T 379101 1464 377637 3.56 1.27061 0.713108 0.881 14.4 0.074784 0.70526 Operations and Procedures Removal of repair material from skin T 379101 460 378641 5.99 1.78979 1.00503 0.835 42.9 0.074939 0.70526 Respiratory Other disorders of nose and nasal sinuses (HES) T 379101 5991 373110 2.25 0.81111 0.456263 0.92 5.5 0.075449 0.707259 Neurosciences Hip pain for 3 months vs no pain T 362682 32691 329991 0.478 -0.737719 0.418358 0.211 1.09 0.077839 0.726799 Operations and Procedures Other operations on internal nose T 379101 2843 376258 2.8 1.03058 0.585191 0.89 8.82 0.078221 0.727517 Summary Bacterial viral and other infectious agents (HES) T 379101 11829 367272 1.9 0.642204 0.365104 0.929 3.89 0.078584 0.727522 Summary Noninflammatory disorders of female genital tract (HES) T 379101 43955 335146 0.534 -0.626863 0.357043 0.265 1.08 0.079138 0.727522 Musculoskeletal Other deforming dorsopathies (HES) T 379101 1558 377543 3.5 1.25329 0.713777 0.864 14.2 0.079112 0.727522 Eye Retinal vascular occlusions (HES) T 379101 466 378635 5.84 1.76482 1.00688 0.812 42 0.079643 0.727528 Operations and Procedures Removal of other substance from skin T 379101 434 378667 5.82 1.76109 1.00511 0.811 41.7 0.07975 0.727528 Summary Had major operations T 173367 111364 62003 1.6 0.469253 0.268941 0.944 2.71 0.081017 0.736262 Gynaecology and Obstetrics Uterine problem (HES and self-reported) T 379101 29689 349412 0.447 -0.805553 0.463947 0.18 1.11 0.08251 0.746984 Digestive system Other diseases of gallbladder (HES) T 379101 1619 377482 3.43 1.23335 0.713363 0.848 13.9 0.083822 0.755986 Operations and Procedures Ventilation support T 379101 2964 376137 2.75 1.01216 0.586358 0.872 8.68 0.084316 0.75757 Operations and Procedures Total prosthetic replacement of hip joint using cement T 379101 4901 374200 2.42 0.885797 0.513827 0.886 6.64 0.084723 0.758362 Haematology Diseases of spleen (HES) T 379101 463 378638 5.63 1.72816 1.00506 0.785 40.4 0.085529 0.762717 Genitourinary Renal failure not requiring dialysis (HES and self-reported) T 379101 483 378618 5.62 1.72568 1.00557 0.783 40.3 0.08614 0.765297 Digestive system Other diseases of anus and rectum (HES) T 379101 21218 357883 0.368 -0.999652 0.583888 0.117 1.16 0.086885 0.768643 Respiratory FEV1 FVC ratio never smoked only T 109851 NA NA NA -0.25205 0.147349 -0.540854 0.036754 0.087162 0.768643 Summary HESCH Diseases of the blood forming organ immune mech BIN (HES) T 379101 22345 356756 1.64 0.497231 0.291836 0.928 2.91 0.088418 0.771145 Operations and Procedures Operations on turbinate of nose T 379101 2985 376116 2.71 0.99654 0.584497 0.862 8.52 0.088203 0.771145 Operations and Procedures Primary fusion of other joint of spine T 379101 465 378636 5.55 1.71407 1.00521 0.774 39.8 0.088159 0.771145 Symptoms Rash and other nonspecific skin eruption (HES) T 379101 1635 377466 3.35 1.20988 0.712829 0.829 13.6 0.089642 0.771305 Operations and Procedures Diagnostic lower respiratory tract T 379101 4809 374292 2.38 0.865439 0.509684 0.875 6.45 0.089509 0.771305 Operations and Procedures Other diagnostic imaging of vascular system T 379101 2957 376144 2.7 0.994041 0.585014 0.858 8.51 0.089286 0.771305 Biological assays Microalbumin in urine T 114296 NA NA NA -0.235276 0.138657 -0.507044 0.036492 0.089732 0.771305 Respiratory Nasal polyp (HES) T 379101 2942 376159 2.69 0.990506 0.585259 0.855 8.48 0.090565 0.773486 Biological assays White blood cell leukocyte count T 367858 NA NA NA -0.142424 0.084172 -0.307402 0.022554 0.090635 0.773486 Other Getting up in morning T 378063 NA NA NA -0.14059 0.083349 -0.303954 0.022774 0.09165 0.779351 Neurosciences Hip pain T 378231 48240 329991 0.59 -0.527772 0.314409 0.319 1.09 0.093227 0.788288 Genitourinary Enlarged prostate (HES and self-reported) T 379101 13062 366039 1.86 0.620536 0.369825 0.901 3.84 0.093363 0.788288 Cardiovascular Leg artery angioplasty stent (self-reported) T 379101 443 378658 5.43 1.69178 1.01059 0.749 39.4 0.09412 0.788362 Operations and Procedures Other operations on retina T 379101 498 378603 5.37 1.67998 1.0063 0.746 38.6 0.095027 0.788362 Medication Glucosamine T 377850 73561 304289 0.665 -0.407606 0.243785 0.413 1.07 0.094526 0.788362 Cardiovascular Angina (HES and self-reported) T 379101 20423 358678 0.374 -0.984646 0.588132 0.118 1.18 0.094093 0.788362 Eye Iritis (HES and self-reported) T 379101 479 378622 5.35 1.67786 1.00487 0.747 38.4 0.094972 0.788362 Digestive system Other diseases of liver (HES) T 379101 3122 375979 2.64 0.970318 0.584492 0.839 8.3 0.096893 0.797605 Operations and Procedures Other operations on fallopian tube T 379101 950 378151 5.45 1.6949 1.02089 0.736 40.3 0.096871 0.797605 Biological assays Reticulocyte count T 361768 NA NA NA -0.14122 0.085132 -0.308078 0.025638 0.097146 0.797605 Symptoms Other symptoms and signs involving the digestive system and abdomen (HES) T 379101 13806 365295 0.193 -1.64394 0.992317 0.0276 1.35 0.097587 0.798468 Symptoms Nausea and vomiting (HES) T 379101 10633 368468 1.9 0.640931 0.388402 0.887 4.06 0.098907 0.80123 Medication Antiinflammatory and antirheumatic products non steroids T 379101 86308 292793 0.69 -0.370769 0.224347 0.445 1.07 0.098401 0.80123 Neurosciences Peripheral nerve disorder (HES and self-reported) T 379101 16736 362365 0.309 -1.17361 0.711969 0.0766 1.25 0.09927 0.80123 Digestive system Anal problem (HES and self-reported) T 379101 23889 355212 0.434 -0.835548 0.506408 0.161 1.17 0.098954 0.80123 Neurosciences Knee pain for 3 months vs no pain T 354701 62522 292179 0.644 -0.439752 0.267054 0.382 1.09 0.099624 0.801367 Summary Symptoms nervous and musculoskeletal systems (HES) T 379101 4763 374338 2.29 0.830502 0.508365 0.847 6.21 0.102328 0.802491 Cardiovascular Angina pectoris (HES) T 379101 16491 362610 0.311 -1.16808 0.714789 0.0766 1.26 0.102224 0.802491 Musculoskeletal Other necrotizing vasculopathies (HES) T 379101 542 378559 5.19 1.64674 1.00651 0.722 37.3 0.101823 0.802491 Cancer Rodent ulcer (self-reported) T 379101 540 378561 5.19 1.64728 1.00617 0.723 37.3 0.101593 0.802491 Operations and Procedures Blood withdrawal T 379101 3031 376070 2.6 0.956402 0.584281 0.828 8.18 0.101654 0.802491 Metabolic Thyroid goitre (HES and self-reported) T 379101 1793 377308 3.22 1.16923 0.714835 0.793 13.1 0.101911 0.802491 Biological assays Mean corpuscular haemoglobin T 367860 NA NA NA 0.137148 0.083983 -0.027459 0.301755 0.10246 0.802491 Respiratory FEV1 never smoked only strict T 84281 NA NA NA -0.272768 0.166279 -0.598675 0.053139 0.100917 0.802491 Operations and Procedures Rectal sigmoid resection (self-reported) T 379101 534 378567 5.15 1.63941 1.0054 0.718 37 0.102974 0.803872 Symptoms Gangrene (HES) T 379101 510 378591 5.14 1.63675 1.00567 0.716 36.9 0.103626 0.806319 Eye Hordeolum and chalazion (HES) T 379101 1665 377436 3.18 1.15741 0.712734 0.787 12.9 0.104397 0.807043 Medication Drugs affecting bone structure and mineralization T 379101 7218 371883 2.13 0.755425 0.464743 0.856 5.29 0.104063 0.807043 Eye Intra ocular pressure Goldmann correlated right T 81176 NA NA NA -0.273691 0.169056 -0.605041 0.057659 0.105461 0.81263 Immuno-inflammation Granulomatous disorders of skin and subcutaneous tissue (HES) T 379101 534 378567 5.04 1.61809 1.00479 0.704 36.1 0.107315 0.8229 Gynaecology and Obstetrics Uterine polypectomy uterine polyps removed (self-reported) T 379101 529 378572 5.08 1.62446 1.00923 0.702 36.7 0.107485 0.8229 Cardiovascular Other peripheral vascular diseases (HES) T 379101 3304 375797 2.56 0.941595 0.586937 0.812 8.1 0.108658 0.828805 Musculoskeletal Osteoporosis without pathological fracture (HES) T 379101 5396 373705 2.28 0.823023 0.514668 0.831 6.24 0.109791 0.828805 Gynaecology and Obstetrics Medical abortion (HES) T 379101 998 378103 5.14 1.63664 1.02385 0.691 38.2 0.109927 0.828805 Other Chest pain or discomfort when walking uphill or hurrying T 47258 12507 34751 2.15 0.765793 0.480095 0.839 5.51 0.110693 0.828805 Operations and Procedures Diagnostic endoscopic examination of larynx T 379101 3294 375807 2.55 0.934349 0.584722 0.809 8.01 0.110057 0.828805 Operations and Procedures Diagnostic percutaneous operations on liver T 379101 1755 377346 3.13 1.14176 0.712931 0.774 12.7 0.109267 0.828805 Eye Intra ocular pressure Goldmann correlated left T 81056 NA NA NA -0.269843 0.169065 -0.60121 0.061524 0.110468 0.828805 Summary Nerve nerve root and plexus disorders (HES) T 379101 16103 362998 0.322 -1.13235 0.71203 0.0798 1.3 0.111764 0.834201 Other Poisoning by narcotics and psychodysleptics (HES) T 379101 598 378503 4.93 1.59523 1.00541 0.687 35.4 0.112594 0.83777 Symptoms Other skin changes (HES) T 379101 565 378536 4.86 1.58099 1.00485 0.678 34.8 0.115637 0.856598 Family history Heart disease (family history - sibling) T 301029 29868 271161 0.539 -0.618146 0.393107 0.249 1.16 0.115844 0.856598 Family history High blood pressure (family history) T 379101 NA NA NA -0.13037 0.083196 -0.293434 0.032694 0.11711 0.863278 Respiratory Pneumonitis due to solids and liquids (HES) T 379101 560 378541 4.83 1.5747 1.00635 0.672 34.7 0.117639 0.86357 Operations and Procedures Anal fissure surgery (self-reported) T 379101 526 378575 4.81 1.57138 1.00488 0.672 34.5 0.117875 0.86357 Symptoms Convulsions (HES) T 379101 1802 377299 3.04 1.11348 0.713095 0.753 12.3 0.118413 0.864851 Mental health Single Probable major depression episode T 91515 6104 85411 1.98 0.682062 0.438061 0.838 4.67 0.11947 0.869902 Medication Antispasmodics in combination with analgesics T 379101 607 378494 4.75 1.55768 1.00513 0.662 34 0.121205 0.872912 Summary Extrapyramidal and movement disorders (HES) T 379101 1814 377287 3.02 1.10514 0.714525 0.744 12.3 0.121942 0.872912 Gynaecology and Obstetrics Hysterectomy with oophorectomy (self-reported) T 379101 668 378433 4.8 1.56842 1.01055 0.662 34.8 0.120652 0.872912 Operations and Procedures Other methods of operation on organ NOC T 379101 1830 377271 3.02 1.10381 0.713373 0.745 12.2 0.121788 0.872912 Other Morning evening person chronotype T 338613 NA NA NA 0.134202 0.086801 -0.035929 0.304333 0.122083 0.872912 Eye Intra ocular pressure corneal compensated right T 81176 NA NA NA -0.261818 0.168994 -0.593046 0.06941 0.121316 0.872912 Cancer Non melanoma skin cancer (self-reported) T 379101 550 378551 4.73 1.55291 1.00556 0.658 33.9 0.12251 0.873342 Operations and Procedures Transluminal operations on iliac artery T 379101 580 378521 4.73 1.55336 1.00935 0.654 34.2 0.123811 0.879982 Operations and Procedures Excision reconstruction of joint T 379101 1872 377229 3 1.09725 0.714604 0.738 12.2 0.124671 0.883457 Infectious disease Diarrhoea presumed infectious (HES) T 379101 5076 374025 2.17 0.776513 0.507751 0.804 5.88 0.126185 0.88619 Haematology Iron deficiency anaemia (HES) T 379101 6915 372186 2.01 0.698116 0.455953 0.822 4.91 0.125741 0.88619 Cardiovascular Aortic valve repair replacement (self-reported) T 379101 561 378540 4.64 1.53402 1.00659 0.645 33.3 0.127515 0.88619 Other Chest pain or discomfort T 375192 59237 315955 1.37 0.317826 0.208632 0.913 2.07 0.127662 0.88619 Summary Mal neo of central nervous system (cancer register) T 379101 562 378539 4.64 1.53493 1.00493 0.647 33.3 0.126663 0.88619 Operations and Procedures Diagnostic testing of genitourinary system T 379101 578 378523 4.66 1.53867 1.00604 0.648 33.5 0.126159 0.88619 Operations and Procedures Prosthetic replacement of other bone using cement T 379101 559 378542 4.63 1.53302 1.00617 0.645 33.3 0.127603 0.88619 Immuno-inflammation Cellulitis (HES and self-reported) T 379101 6668 372433 2 0.693277 0.456408 0.818 4.89 0.128766 0.891255 Eye Other disorders of cornea (HES) T 379101 582 378519 4.59 1.52448 1.00507 0.641 32.9 0.129319 0.892056 Cardiovascular Diastolic blood pressure mean T 357246 NA NA NA 0.129927 0.085729 -0.038101 0.297955 0.129631 0.892056 Summary HESCH Congen malfor deform and chrom abnormalities (HES) T 379101 4981 374120 2.15 0.765167 0.507369 0.795 5.81 0.131527 0.89221 Operations and Procedures Endoscopic ultrasound examination of pancreas T 379101 605 378496 4.57 1.51947 1.00507 0.637 32.8 0.130584 0.89221 Operations and Procedures Excision of nail T 379101 608 378493 4.56 1.51693 1.00466 0.636 32.7 0.131069 0.89221 Operations and Procedures Injection of other substance into organ NOC T 379101 1838 377263 2.93 1.07611 0.713389 0.725 11.9 0.131439 0.89221 Immuno-inflammation Allergy or anaphylactic reaction to food (HES and self-reported) T 379101 1833 377268 2.93 1.0757 0.713014 0.725 11.9 0.131383 0.89221 Medication Iron T 377850 11432 366418 0.226 -1.48783 0.991979 0.0323 1.58 0.13365 0.901475 Cardiovascular Mitral valve disease (HES and self-reported) T 379101 3385 375716 2.41 0.880128 0.586735 0.763 7.62 0.133603 0.901475 Operations and Procedures Urethral catheterisation of bladder T 379101 10309 368792 1.79 0.584905 0.39091 0.834 3.86 0.134585 0.905217 Infectious disease Other septicaemia (HES) T 379101 3387 375714 2.39 0.872661 0.585169 0.76 7.54 0.135883 0.90991 Mental health Probable recurrent major depression moderate T 58838 11697 47141 0.403 -0.90992 0.610408 0.122 1.33 0.136047 0.90991 Other Snoring T 352753 131409 221344 1.3 0.264232 0.178399 0.918 1.85 0.138572 0.913961 Operations and Procedures Lung removal pneumonectomy lobectomy (self-reported) T 379101 614 378487 4.44 1.49109 1.00585 0.619 31.9 0.138228 0.913961 Operations and Procedures Diagnostic endoscopic examination of ileum T 379101 590 378511 4.45 1.49319 1.00462 0.621 31.9 0.137194 0.913961 Eye Retinal arteryvein occlusion (HES and self-reported) T 379101 614 378487 4.45 1.49307 1.0063 0.619 32 0.137881 0.913961 Cardiovascular Pericardial effusion (HES and self-reported) T 379101 600 378501 4.43 1.48919 1.00543 0.618 31.8 0.138568 0.913961 Operations and Procedures Introduction of non removable material into organ NOC T 379101 611 378490 4.44 1.4896 1.00701 0.616 31.9 0.139077 0.914758 Symptoms Hepatomegaly and splenomegaly (HES) T 379101 590 378511 4.41 1.48395 1.00563 0.614 31.7 0.140039 0.918548 Operations and Procedures High cost immunosuppressant drugs T 379101 602 378499 4.4 1.48072 1.00483 0.613 31.5 0.140588 0.919615 Genitourinary Diseases of Bartholin s gland (HES) T 379101 665 378436 4.39 1.47931 1.00932 0.607 31.7 0.142744 0.93116 Summary Diabetes mellitus (HES) T 379101 17982 361119 0.425 -0.856221 0.585735 0.135 1.34 0.143799 0.935479 Haematology Anaemia in chronic diseases classified elsewhere (HES) T 379101 657 378444 4.33 1.46447 1.00553 0.603 31 0.145279 0.94134 Musculoskeletal Psoriatic and enteropathic arthropathies (HES) T 379101 650 378451 4.31 1.46181 1.0046 0.602 30.9 0.145637 0.94134 Operations and Procedures Excision of organ NOC T 379101 1832 377269 2.82 1.03636 0.712657 0.697 11.4 0.145886 0.94134 Infectious disease Candidiasis (HES) T 379101 1983 377118 2.8 1.0283 0.713094 0.691 11.3 0.149295 0.956511 ENT Tonsillectomy adenoids (self-reported) T 379101 59321 319780 0.682 -0.383031 0.265451 0.405 1.15 0.149036 0.956511 Operations and Procedures Open drainage of bladder T 379101 606 378495 4.26 1.44876 1.00505 0.594 30.5 0.14945 0.956511 Digestive system Haemochromatosis (HES and self-reported) T 379101 635 378466 4.26 1.44989 1.00681 0.592 30.7 0.149844 0.956511 Operations and Procedures Excision of dental lesion of jaw T 379101 624 378477 4.2 1.43608 1.00454 0.587 30.1 0.152837 0.970413 Operations and Procedures Excision of sigmoid colon T 379101 638 378463 4.22 1.43868 1.00539 0.587 30.2 0.152437 0.970413 Summary Other congenital malformations of the digestive system (HES) T 379101 632 378469 4.19 1.43164 1.00495 0.584 30 0.154276 0.976945 Operations and Procedures Suture of organ NOC T 379101 640 378461 4.16 1.42615 1.00454 0.581 29.8 0.155693 0.983302 Immuno-inflammation Pruritus (HES) T 379101 705 378396 4.16 1.42475 1.00459 0.58 29.8 0.156121 0.983397 Gynaecology and Obstetrics Mastectomy (self-reported) T 379101 3844 375257 2.31 0.835868 0.591352 0.724 7.35 0.157513 0.987445 Musculoskeletal Grip strength maximumValue T 378322 NA NA NA -0.117497 0.083142 -0.280455 0.045461 0.157593 0.987445 Summary HESCH Diseases of the eye and adnexa (HES) T 379101 35574 343527 1.44 0.362717 0.257085 0.868 2.38 0.158279 0.98914 Operations and Procedures Other operations on spermatic cord T 379101 598 378503 4.14 1.42065 1.00905 0.573 29.9 0.159158 0.98952 Operations and Procedures Other large intestine T 379101 3469 375632 2.28 0.822278 0.58406 0.724 7.15 0.159171 0.98952 Respiratory Pleural plaque (HES) T 379101 645 378456 4.11 1.4135 1.01329 0.564 30 0.163026 0.995679 Eye Eye surgery (self-reported) T 379101 3495 375606 2.26 0.815711 0.583944 0.72 7.1 0.162444 0.995679 Neurosciences Stomach abdominal pain for 3 months vs no pain T 357806 17535 340271 0.443 -0.814884 0.584247 0.141 1.39 0.163089 0.995679 Operations and Procedures Freeing of tendon T 379101 652 378449 4.08 1.40662 1.00453 0.57 29.2 0.16143 0.995679 Neurosciences Back pain T 378231 102012 276219 0.753 -0.284297 0.202874 0.506 1.12 0.16111 0.995679 Metabolic Type 2 diabetes (HES and self-reported) T 379101 17351 361750 0.441 -0.819551 0.58602 0.14 1.39 0.161962 0.995679 Gynaecology and Obstetrics Vaginal prolapseuterine prolapse (HES and self-reported) T 379101 11476 367625 0.243 -1.41275 1.00829 0.0337 1.76 0.161174 0.995679 Medication Stomatological preparations T 379101 59623 319478 0.914 -0.089727 0.243209 0.568 1.47 0.712182 0.998648 Medication Drugs for peptic ulcer and gastro oesophageal reflux disease gord T 379101 45634 333467 1.18 0.16366 0.248861 0.723 1.92 0.510771 0.998648 Medication Drugs for functional gastrointestinal disorders T 379101 3769 375332 0.752 -0.284907 1.00434 0.105 5.38 0.776658 0.998648 Medication Propulsives T 379101 1384 377717 2.06 0.72186 1.00443 0.287 14.7 0.472339 0.998648 Medication Antiemetics and antinauseants T 379101 234 378867 0.000121 -9.01858 197.217 1.62E-172 9.07E+163 0.963526 0.998648 Medication Bile therapy T 379101 233 378868 0.00012 -9.02821 194.156 6.46E-170 2.23E+161 0.962912 0.998648 Medication Drugs for constipation T 379101 6110 372991 0.46 -0.777074 1.00437 0.0642 3.29 0.439113 0.998648 Medication Intestinal antiinfectives T 379101 693 378408 0.000103 -9.18444 120.214 4.82E-107 2.19E+98 0.9391 0.998648 Medication Antipropulsives T 379101 2041 377060 8.91E-05 -9.32607 73.2745 3.78E-67 2.10E+58 0.898722 0.998648 Medication Antiobesity preparations excl diet products T 379101 958 378143 7.51E-05 -9.49719 120.415 2.38E-107 2.37E+98 0.937135 0.998648 Medication Digestives incl enzymes T 379101 255 378846 9.96E-05 -9.21478 197.598 6.30E-173 1.57E+164 0.962805 0.998648 Medication Multivitamins combinations T 379101 19000 360101 1.03 0.028753 0.388049 0.481 2.2 0.940935 0.998648 Medication Vitamin a and d incl combinations of the two T 379101 10919 368182 0.522 -0.650789 0.715904 0.128 2.12 0.363327 0.998648 Medication Vitamin b1 plain and in combination with vitamin b6 and b12 T 379101 3169 375932 6.20E-05 -9.68835 73.1822 3.15E-67 1.22E+58 0.894678 0.998648 Medication Ascorbic acid vitamin c incl combinations T 379101 6192 372909 1.81 0.592913 0.507561 0.669 4.89 0.242742 0.998648 Medication Other plain vitamin preparations T 379101 4840 374261 4.11E-05 -10.0997 72.8733 3.83E-67 4.41E+57 0.889772 0.998648 Medication Other mineral supplements T 379101 878 378223 8.93E-05 -9.32369 117.648 6.41E-105 1.24E+96 0.936833 0.998648 Medication Antithrombotic agents T 379101 59142 319959 0.812 -0.208092 0.255159 0.493 1.34 0.414764 0.998648 Medication Antifibrinolytics T 379101 502 378599 8.14E-05 -9.41629 176.66 3.42E-155 1.93E+146 0.957491 0.998648 Medication Iron preparations T 379101 19982 359119 0.824 -0.193824 0.417581 0.363 1.87 0.642534 0.998648 Medication Vitamin b12 and folic acid T 379101 8262 370839 0.343 -1.06999 1.00387 0.048 2.45 0.286485 0.998648 Medication Irrigating solutions T 379101 1449 377652 5.24E-05 -9.85731 118.734 4.47E-106 6.13E+96 0.933836 0.998648 Medication I v solution additives T 379101 936 378165 8.36E-05 -9.38894 117.979 3.14E-105 2.23E+96 0.93657 0.998648 Medication Cardiac glycosides T 379101 1042 378059 2.56 0.941801 1.00876 0.355 18.5 0.350498 0.998648 Medication Antiarrhythmics class i and iii T 379101 1297 377804 2.05 0.717523 1.00513 0.286 14.7 0.475315 0.998648 Medication Cardiac stimulants excl cardiac glycosides T 379101 304 378797 8.27E-05 -9.40081 196.614 3.60E-172 1.90E+163 0.961865 0.998648 Medication Vasodilators used in cardiac diseases T 379101 5385 373716 3.75E-05 -10.1915 69.8385 1.34E-64 1.05E+55 0.883977 0.998648 Medication Other cardiac preparations T 379101 50254 328847 0.812 -0.208005 0.266936 0.481 1.37 0.435844 0.998648 Medication Antiadrenergic agents centrally acting T 379101 1115 377986 6.65E-05 -9.61791 119.382 1.60E-106 2.77E+97 0.935788 0.998648 Medication Antiadrenergic agents peripherally acting T 379101 4727 374374 1.69 0.522233 0.588188 0.532 5.34 0.374612 0.998648 Medication Antihypertensives and diuretics in combination T 379101 1142 377959 6.48E-05 -9.64448 119.41 1.47E-106 2.85E+97 0.935627 0.998648 Medication Low ceiling diuretics thiazides T 379101 23557 355544 1.04 0.041959 0.349333 0.526 2.07 0.904395 0.998648 Medication Low ceiling diuretics excl thiazides T 379101 1449 377652 1.83 0.602175 1.00549 0.254 13.1 0.549247 0.998648 Medication High ceiling diuretics T 379101 3930 375171 2.19 0.784943 0.587279 0.693 6.93 0.181361 0.998648 Medication Potassium sparing agents T 379101 950 378151 7.25E-05 -9.53198 118.63 7.59E-106 6.92E+96 0.935959 0.998648 Medication Diuretics and potassium sparing agents in combination T 379101 27954 351147 1.2 0.181227 0.307636 0.656 2.19 0.555798 0.998648 Medication Peripheral vasodilators T 379101 334 378767 8.08E-05 -9.42343 197.871 2.99E-173 2.18E+164 0.962016 0.998648 Medication Hemorrhoids and anal fissures for topical use T 379101 11708 367393 0.681 -0.383599 0.58506 0.216 2.14 0.512045 0.998648 Medication Beta blocking agents T 379101 27196 351905 0.986 -0.01435 0.332678 0.514 1.89 0.965595 0.998648 Medication Beta blocking agents and thiazides T 379101 27196 351905 0.987 -0.01348 0.332651 0.514 1.89 0.967677 0.998648 Medication Beta blocking agents and other diuretics T 379101 15555 363546 0.677 -0.390219 0.510779 0.249 1.84 0.444886 0.998648 Medication Beta blocking agents thiazides and other diuretics T 379101 15312 363789 0.689 -0.373021 0.510746 0.253 1.87 0.465179 0.998648 Medication Beta blocking agents other combinations T 379101 42301 336800 0.863 -0.14694 0.28774 0.491 1.52 0.609582 0.998648 Medication Selective calcium channel blockers with mainly vascular effects T 379101 24151 354950 0.747 -0.291183 0.392843 0.346 1.61 0.458559 0.998648 Medication Selective calcium channel blockers with direct cardiac effects T 379101 3557 375544 0.77 -0.26119 1.0058 0.107 5.53 0.795107 0.998648 Medication Calcium channel blockers and diuretics T 379101 18780 360321 0.988 -0.012457 0.392708 0.457 2.13 0.974695 0.998648 Medication Ace inhibitors plain T 379101 38569 340532 0.937 -0.064849 0.286854 0.534 1.64 0.821147 0.998648 Medication Ace inhibitors combinations T 379101 54539 324562 0.897 -0.108943 0.253821 0.545 1.47 0.667768 0.998648 Medication Angiotensin ii antagonists plain T 379101 16106 362995 1.02 0.020787 0.420369 0.448 2.33 0.960562 0.998648 Medication Angiotensin ii antagonists combinations T 379101 30598 348503 0.774 -0.256587 0.349348 0.39 1.53 0.462659 0.998648 Medication Other agents acting on the renin angiotensin system T 379101 16224 362877 0.807 -0.214342 0.459578 0.328 1.99 0.640937 0.998648 Medication Lipid modifying agents plain T 379101 93186 285915 0.754 -0.282661 0.217421 0.492 1.15 0.193579 0.998648 Medication Antifungals for topical use T 379101 3710 375391 1.48 0.39142 0.712688 0.366 5.98 0.582857 0.998648 Medication Antifungals for systemic use T 379101 843 378258 3.17 1.15518 1.00444 0.443 22.7 0.250114 0.998648 Medication Emollients and protectives T 379101 1288 377813 2.05 0.717535 1.00429 0.286 14.7 0.474939 0.998648 Medication Cicatrizants T 379101 2968 376133 6.69E-05 -9.61206 73.0307 4.58E-67 9.78E+57 0.895287 0.998648 Medication Antipruritics incl antihistamines anesthetics etc T 379101 592 378509 0.000112 -9.0976 120.598 2.48E-107 5.06E+98 0.939866 0.998648 Medication Antibiotics for topical use T 379101 1432 377669 4.81E-05 -9.9427 120.938 5.46E-108 4.23E+98 0.934477 0.998648 Medication Chemotherapeutics for topical use T 379101 1020 378081 2.62 0.961398 1.00413 0.365 18.7 0.338341 0.998648 Medication Corticosteroids combinations with antiseptics T 379101 6117 372984 1.31 0.27277 0.584076 0.418 4.13 0.640491 0.998648 Medication Corticosteroids other combinations T 379101 9688 369413 1.4 0.334665 0.455798 0.572 3.41 0.462802 0.998648 Medication Antiseptics and disinfectants T 379101 239 378862 0.000114 -9.0801 197.355 1.16E-172 1.12E+164 0.963303 0.998648 Medication Other dermatological preparations T 379101 20932 358169 0.928 -0.075089 0.388495 0.433 1.99 0.846737 0.998648 Medication Antiinf and antiseptics excl comb with cortico T 379101 8523 370578 1.3 0.260982 0.507391 0.48 3.51 0.606999 0.998648 Medication Other gynecologicals T 379101 52465 326636 0.775 -0.254432 0.26677 0.46 1.31 0.340211 0.998648 Medication Hormonal contraceptives for systemic use T 379101 5576 373525 0.61 -0.493905 1.01903 0.0828 4.5 0.627902 0.998648 Medication Androgens T 379101 555 378546 4.51E-05 -10.0074 192.89 2.90E-169 7.00E+159 0.958623 0.998648 Medication Estrogens T 379101 10090 369011 0.85 -0.162924 0.590095 0.267 2.7 0.782473 0.998648 Medication Progestogens T 379101 2010 377091 1.64 0.4943 1.01399 0.225 12 0.625918 0.998648 Medication Androgens and female sex hormones in combination T 379101 421 378680 5.85E-05 -9.74627 194.714 1.06E-170 3.24E+161 0.960079 0.998648 Medication Progestogens and estrogens in combination T 379101 8666 370435 0.326 -1.11978 1.00927 0.0451 2.36 0.267215 0.998648 Medication Other sex hormones and modulators of the genital system T 379101 368 378733 9.92E-05 -9.21842 177.305 1.18E-155 8.35E+146 0.958535 0.998648 Medication Urologicals T 379101 6031 373070 3.00E-05 -10.4132 72.4913 5.91E-67 1.53E+57 0.885779 0.998648 Medication Drugs used in benign prostatic hypertrophy T 379101 6797 372304 0.359 -1.02343 1.00917 0.0497 2.6 0.310522 0.998648 Medication Corticosteroids for systemic use plain T 379101 6943 372158 1.16 0.147556 0.584069 0.369 3.64 0.800551 0.998648 Medication Thyroid preparations T 379101 21493 357608 0.915 -0.089022 0.392721 0.424 1.98 0.820673 0.998648 Medication Antithyroid preparations T 379101 334 378767 7.78E-05 -9.46088 196.772 2.49E-172 2.44E+163 0.961652 0.998648 Summary Intestinal infectious diseases (HES) T 379101 8022 371079 1.37 0.318309 0.507756 0.508 3.72 0.53073 0.998648 Summary Other bacterial diseases (HES) T 379101 4393 374708 1.84 0.611209 0.585039 0.585 5.8 0.296147 0.998648 Summary Infections sexual mode of transmission (HES) T 379101 253 378848 0.00011 -9.11253 197.003 2.24E-172 5.43E+163 0.963106 0.998648 Summary Viral infections of the central nervous system (HES) T 379101 233 378868 9.99E-05 -9.21125 199.143 3.06E-174 3.26E+165 0.963108 0.998648 Summary Viral infections skin and mucous memb (HES) T 379101 1422 377679 1.91 0.645779 1.00406 0.267 13.6 0.520115 0.998648 Summary Viral hepatitis (HES) T 379101 525 378576 4.81E-05 -9.94293 197.057 8.78E-173 2.63E+163 0.959758 0.998648 Summary Other viral diseases (HES) T 379101 1781 377320 1.53 0.426758 1.00391 0.214 11 0.670766 0.998648 Summary Mycoses (HES) T 379101 2468 376633 2.22 0.798837 0.712946 0.55 8.99 0.262512 0.998648 Summary Nutritional anaemias (HES) T 379101 7757 371344 1.8 0.585498 0.456011 0.735 4.39 0.199158 0.998648 Summary Haemolytic anaemias (HES) T 379101 276 378825 9.25E-05 -9.28837 197.535 6.62E-173 1.29E+164 0.962496 0.998648 Summary Aplastic and other anaemias (HES) T 379101 11319 367782 1.22 0.198057 0.45613 0.499 2.98 0.664134 0.998648 Summary Coagulation defects purpura and other haemorrhagic conditions (HES) T 379101 2426 376675 7.50E-05 -9.49785 73.2987 3.03E-67 1.85E+58 0.896901 0.998648 Summary Certain disorders involving the immune mechanism (HES) T 379101 976 378125 6.70E-05 -9.61048 120.765 1.07E-107 4.20E+98 0.936571 0.998648 Summary Disorders of thyroid gland (HES) T 379101 15440 363661 0.905 -0.099705 0.459064 0.368 2.23 0.828059 0.998648 Summary Glucose regulation and pancreatic internal secretion (HES) T 379101 831 378270 8.33E-05 -9.39351 119.694 1.08E-106 6.40E+97 0.937447 0.998648 Summary Disorders of other endocrine glands (HES) T 379101 2354 376747 1.15 0.140199 1.00392 0.161 8.23 0.888935 0.998648 Summary Other nutritional deficiencies (HES) T 379101 1249 377852 5.56E-05 -9.79699 120.802 8.25E-108 3.75E+98 0.935363 0.998648 Summary Obesity and other hyperalimentation (HES) T 379101 9921 369180 1.1 0.094774 0.507518 0.407 2.97 0.851864 0.998648 Summary Organic including symptomatic mental disorders (HES) T 379101 1447 377654 5.05E-05 -9.89428 115.32 3.47E-103 7.33E+93 0.931627 0.998648 Summary Mental disorders due to psychoactive sub (HES) T 379101 14024 365077 1.58 0.460355 0.366183 0.773 3.25 0.208691 0.998648 Summary Schizophrenia schizotypal and delusional disorders (HES) T 379101 899 378202 7.56E-05 -9.48943 120.336 2.80E-107 2.05E+98 0.937146 0.998648 Summary Mood affective disorders (HES) T 379101 11549 367552 0.701 -0.354542 0.583751 0.223 2.2 0.543617 0.998648 Summary Neurotic stress related and somatoform disorders (HES) T 379101 6748 372353 0.4 -0.91529 1.00357 0.056 2.86 0.361752 0.998648 Summary Behav syn assoc with phys disturb and phys fact (HES) T 379101 424 378677 5.92E-05 -9.73418 197.241 7.54E-173 4.65E+163 0.960639 0.998648 Summary Disorders of adult personality and behaviour (HES) T 379101 350 378751 7.12E-05 -9.54961 196.77 2.28E-172 2.22E+163 0.961292 0.998648 Summary Disorders of psychological development (HES) T 379101 287 378814 8.05E-05 -9.4269 198.566 7.64E-174 8.49E+164 0.962135 0.998648 Summary Inflammatory diseases of the central nervous system (HES) T 379101 536 378565 4.52E-05 -10.0052 199.594 5.71E-175 3.57E+165 0.96002 0.998648 Summary Atrophies affecting central nervous system (HES) T 379101 368 378733 6.69E-05 -9.61265 197.447 5.69E-173 7.86E+163 0.961171 0.998648 Summary Other degenerative diseases of the nervous system (HES) T 379101 907 378194 2.99 1.0953 1.00654 0.416 21.5 0.276516 0.998648 Summary Demyelinating diseases of the central nervous system (HES) T 379101 1406 377695 1.95 0.669318 1.00443 0.273 14 0.505178 0.998648 Summary Episodic and paroxysmal disorders (HES) T 379101 12991 366110 1.02 0.019298 0.455708 0.417 2.49 0.966222 0.998648 Summary Polyneuropathies and peripheral nervous system (HES) T 379101 1669 377432 3.99E-05 -10.1294 119.826 4.01E-107 3.97E+97 0.932632 0.998648 Summary Diseases of myoneural junction and muscle (HES) T 379101 482 378619 5.07E-05 -9.88982 199.215 1.35E-174 1.91E+165 0.960406 0.998648 Summary Cerebral palsy and other paralytic syndromes (HES) T 379101 2036 377065 2.63 0.967368 0.713073 0.65 10.6 0.174902 0.998648 Summary Other disorders of the nervous system (HES) T 379101 3742 375359 4.77E-05 -9.95088 73.4486 1.44E-67 1.58E+58 0.892232 0.998648 Summary Disorders of eyelid lacrimal system and orbit (HES) T 379101 8748 370353 0.938 -0.063566 0.584387 0.299 2.95 0.913382 0.998648 Summary Disorders of conjunctiva (HES) T 379101 908 378193 7.52E-05 -9.49577 120.518 1.95E-107 2.90E+98 0.937198 0.998648 Summary Disorders of lens (HES) T 379101 18482 360619 1.37 0.316731 0.352973 0.687 2.74 0.369546 0.998648 Summary Disorders of choroid and retina (HES) T 379101 6755 372346 1.15 0.14139 0.585728 0.365 3.63 0.809252 0.998648 Summary Glaucoma (HES) T 379101 4048 375053 1.32 0.276403 0.714777 0.325 5.35 0.69898 0.998648 Summary Disorders of vitreous body and globe (HES) T 379101 1565 377536 1.6 0.467832 1.00507 0.223 11.4 0.641593 0.998648 Summary Ocular musclesocular movement (HES) T 379101 2672 376429 0.969 -0.031748 1.00412 0.135 6.93 0.974777 0.998648 Summary Visual disturbances and blindness (HES) T 379101 3428 375673 0.777 -0.25266 1.00368 0.109 5.55 0.801248 0.998648 Summary Other disorders of eye and adnexa (HES) T 379101 876 378225 7.66E-05 -9.47685 120.579 1.76E-107 3.34E+98 0.937355 0.998648 Summary Diseases of external ear (HES) T 379101 1324 377777 4.96E-05 -9.91224 120.745 8.22E-108 2.99E+98 0.934573 0.998648 Summary Diseases of middle ear and mastoid (HES) T 379101 2903 376198 0.934 -0.067886 1.00366 0.131 6.68 0.946074 0.998648 Summary Diseases of inner ear (HES) T 379101 1848 377253 3.69E-05 -10.2077 120.734 6.25E-108 2.18E+98 0.932621 0.998648 Summary Other disorders of ear (HES) T 379101 4112 374989 0.642 -0.442865 1.00396 0.0898 4.59 0.659127 0.998648 Summary Chronic rheumatic heart diseases (HES) T 379101 1969 377132 3.66E-05 -10.2165 117.166 6.75E-105 1.98E+95 0.930515 0.998648 Summary Hypertensive diseases (HES) T 379101 70604 308497 0.922 -0.08116 0.227978 0.59 1.44 0.721841 0.998648 Summary Ischaemic heart diseases (HES) T 379101 27652 351449 0.643 -0.442215 0.39494 0.296 1.39 0.262841 0.998648 Summary Pulmonary heart disease and diseases of pulmonary circulation (HES) T 379101 3992 375109 2 0.693109 0.585203 0.635 6.3 0.236259 0.998648 Summary Other forms of heart disease (HES) T 379101 26042 353059 1.24 0.21531 0.30828 0.678 2.27 0.484912 0.998648 Summary Diseases of veins lymphatic vessels (HES) T 379101 35400 343701 1.16 0.144423 0.273377 0.676 1.97 0.597296 0.998648 Summary Other and unspecified disorders of the circulatory system (HES) T 379101 4939 374162 1.64 0.494876 0.585308 0.521 5.17 0.397834 0.998648 Summary Acute upper respiratory infections (HES) T 379101 2654 376447 6.94E-05 -9.57562 73.4857 1.95E-67 2.48E+58 0.896324 0.998648 Summary Other diseases of upper respiratory tract (HES) T 379101 13139 365962 1.44 0.367489 0.388204 0.675 3.09 0.343822 0.998648 Summary Lung diseases due to external agents (HES) T 379101 898 378203 2.97 1.08955 1.00702 0.413 21.4 0.279271 0.998648 Summary Respiratory diseases interstitium (HES) T 379101 1501 377600 1.81 0.593767 1.00568 0.252 13 0.554914 0.998648 Summary Diseases of oral cavity salivary glands and jaws (HES) T 379101 14224 364877 0.561 -0.578788 0.583604 0.179 1.76 0.32132 0.998648 Summary Diseases of oesophagus stomach and duodenum (HES) T 379101 55390 323711 1.1 0.098072 0.233605 0.698 1.74 0.674616 0.998648 Summary Diseases of appendix (HES) T 379101 3245 375856 1.61 0.473679 0.712504 0.397 6.49 0.506173 0.998648 Summary Hernia (HES) T 379101 42709 336392 0.772 -0.25931 0.294257 0.433 1.37 0.378191 0.998648 Summary Noninfective enteritis and colitis (HES) T 379101 17546 361555 0.764 -0.269145 0.455589 0.313 1.87 0.554679 0.998648 Summary Other diseases of intestines (HES) T 379101 59649 319452 0.739 -0.301971 0.260069 0.444 1.23 0.245594 0.998648 Summary Diseases of peritoneum (HES) T 379101 3415 375686 1.61 0.475456 0.712552 0.398 6.5 0.504607 0.998648 Summary Other diseases of the digestive system (HES) T 379101 11473 367628 1.17 0.154746 0.455791 0.478 2.85 0.734225 0.998648 Summary Infections of the skin and subcutaneous tissue (HES) T 379101 9696 369405 1.37 0.314332 0.456004 0.56 3.35 0.490623 0.998648 Summary Dermatitis and eczema (HES) T 379101 2862 376239 1.94 0.660405 0.712521 0.479 7.82 0.354001 0.998648 Summary Papulosquamous disorders (HES) T 379101 2604 376497 1.05 0.048407 1.00391 0.147 7.51 0.961542 0.998648 Summary Urticaria and erythema (HES) T 379101 948 378153 7.16E-05 -9.54463 120.976 7.55E-108 6.79E+98 0.937115 0.998648 Summary Radiation related disorders of the skin and subcutaneous tissue (HES) T 379101 2288 376813 8.22E-05 -9.40647 71.3925 1.39E-65 4.85E+56 0.895176 0.998648 Summary Disorders of skin appendages (HES) T 379101 9390 369711 0.869 -0.140353 0.583669 0.277 2.73 0.809969 0.998648 Summary Other disorders of the skin and subcutaneous tissue (HES) T 379101 14568 364533 1.12 0.10986 0.417867 0.492 2.53 0.792623 0.998648 Summary Infectious arthropathies (HES) T 379101 428 378673 5.50E-05 -9.8081 198.105 1.29E-173 2.35E+164 0.960513 0.998648 Summary Inflammatory polyarthropathies (HES) T 379101 17341 361760 0.957 -0.043623 0.419095 0.421 2.18 0.917099 0.998648 Summary Arthrosis (HES) T 379101 40307 338794 0.938 -0.064404 0.284985 0.536 1.64 0.821208 0.998648 Summary Other joint disorders (HES) T 379101 35549 343552 1.15 0.136524 0.273284 0.671 1.96 0.617379 0.998648 Summary Spondylopathies (HES) T 379101 10706 368395 1.03 0.029828 0.508524 0.38 2.79 0.953226 0.998648 Summary Other dorsopathies (HES) T 379101 18099 361002 0.891 -0.11512 0.417248 0.393 2.02 0.782622 0.998648 Summary Disorders of muscles (HES) T 379101 1025 378076 2.63 0.965184 1.0044 0.367 18.8 0.336575 0.998648 Summary Disorders of synovium and tendon (HES) T 379101 8361 370740 0.96 -0.041108 0.583795 0.306 3.01 0.943863 0.998648 Summary Other soft tissue disorders (HES) T 379101 25100 354001 1.31 0.273554 0.302245 0.727 2.38 0.365425 0.998648 Summary Disorders of bone density and structure (HES) T 379101 8188 370913 1.42 0.350573 0.51095 0.522 3.87 0.492637 0.998648 Summary Other osteopathies (HES) T 379101 2866 376235 1.92 0.654918 0.71251 0.476 7.78 0.358006 0.998648 Summary Chondropathies (HES) T 379101 1094 378007 2.38 0.867263 1.00417 0.333 17 0.387775 0.998648 Summary Musculoskeletal system and connective tissue (HES) T 379101 844 378257 7.95E-05 -9.43992 121.144 6.03E-108 1.05E+99 0.937889 0.998648 Summary Glomerular diseases (HES) T 379101 1942 377159 3.50E-05 -10.2592 119.411 7.94E-107 1.55E+97 0.931534 0.998648 Summary Renal tubulo interstitial diseases (HES) T 379101 3453 375648 0.769 -0.263111 1.00369 0.107 5.5 0.79321 0.998648 Summary Renal failure (HES) T 379101 7743 371358 1.04 0.03733 0.586812 0.329 3.28 0.949276 0.998648 Summary Urolithiasis (HES) T 379101 5984 373117 2.95E-05 -10.4308 72.3716 7.35E-67 1.19E+57 0.885399 0.998648 Summary Other disorders of kidney and ureter (HES) T 379101 2376 376725 7.70E-05 -9.47121 72.2875 2.26E-66 2.62E+57 0.895758 0.998648 Summary Other diseases of urinary system (HES) T 379101 26755 352346 1.13 0.119251 0.315364 0.607 2.09 0.705329 0.998648 Summary Disorders of breast (HES) T 379101 4857 374244 0.604 -0.503674 1.00654 0.084 4.35 0.616794 0.998648 Summary Inflammatory diseases of female pelvic organs (HES) T 379101 5417 373684 1.65 0.50127 0.591622 0.518 5.26 0.396839 0.998648 Summary Other disorders of the genitourinary system (HES) T 379101 1063 378038 6.63E-05 -9.62131 118.654 6.63E-106 6.64E+96 0.935373 0.998648 Summary Pregnancy with abortive outcome (HES) T 379101 3363 375738 1.3 0.259559 1.02381 0.174 9.64 0.799864 0.998648 Summary Oed prot and hyprtn dis in preg chldbrth (HES) T 379101 1199 377902 4.92E-08 -16.8274 5340.98 0 Inf 0.997486 0.998648 Summary Other maternal disorders predominantly related to pregnancy (HES) T 379101 2789 376312 5.89E-08 -16.6478 3227.25 0 Inf 0.995884 0.998648 Summary Maternal care related to the fetus (HES) T 379101 6059 373042 2.45E-08 -17.5246 3167.92 0 Inf 0.995586 0.998648 Summary Complications of labour and delivery (HES) T 379101 8512 370589 0.47 -0.755685 1.03598 0.0617 3.58 0.465733 0.998648 Summary Delivery (HES) T 379101 2450 376651 6.07E-08 -16.6176 3233.63 0 Inf 0.9959 0.998648 Summary Complications predominantly related to the puerperium (HES) T 379101 557 378544 1.09E-07 -16.0317 5305.27 0 Inf 0.997589 0.998648 Summary Other obstetric conditions not elsewhere classified (HES) T 379101 1624 377477 3.04 1.11077 1.03097 0.403 22.9 0.281302 0.998648 Summary Congenital malformations of the nervous system (HES) T 379101 249 378852 0.000106 -9.15587 198.368 1.48E-173 7.55E+164 0.963186 0.998648 Summary Congenital malformations of eye ear face and neck (HES) T 379101 307 378794 7.79E-05 -9.46057 198.918 3.71E-174 1.64E+165 0.962067 0.998648 Summary Congenital malformations of genital organs (HES) T 379101 628 378473 0.00011 -9.11309 120.445 3.29E-107 3.69E+98 0.939688 0.998648 Summary Congenital malformations of the urinary system (HES) T 379101 821 378280 7.89E-05 -9.44687 120.804 1.17E-107 5.34E+98 0.937669 0.998648 Summary Congenital malformations musculoskeletal system (HES) T 379101 711 378390 3.73 1.3165 1.00481 0.521 26.7 0.190128 0.998648 Summary Other congenital malformations (HES) T 379101 615 378486 0.000108 -9.13309 120.961 1.17E-107 9.95E+98 0.939814 0.998648 Summary Symptoms circulatory and respiratory systems (HES) T 379101 45652 333449 1.07 0.070645 0.253542 0.653 1.76 0.780528 0.998648 Summary Symptoms and signs involving the digestive system and abdomen (HES) T 379101 52090 327011 0.767 -0.26512 0.273615 0.449 1.31 0.332569 0.998648 Summary Symptoms and signs involving the urinary system (HES) T 379101 26525 352576 1.09 0.082935 0.316711 0.584 2.02 0.793426 0.998648 Summary Symptoms cognition perception emotional state (HES) T 379101 8138 370963 1.35 0.299731 0.508322 0.498 3.65 0.555427 0.998648 Summary Symptoms and signs involving speech and voice (HES) T 379101 2293 376808 2.37 0.860792 0.71316 0.584 9.57 0.227428 0.998648 Summary General symptoms and signs (HES) T 379101 41556 337545 1.11 0.107817 0.258863 0.671 1.85 0.677043 0.998648 Summary Abnormal findings on examination of blood without diagnosis (HES) T 379101 7295 371806 1.45 0.369622 0.511881 0.531 3.95 0.470242 0.998648 Summary Abnormal findings of urine without diagnosis (HES) T 379101 652 378449 0.000106 -9.15415 120.62 2.24E-107 4.99E+98 0.939505 0.998648 Summary Abn exm of fluids subst wo diag (HES) T 379101 1857 377244 4.03E-05 -10.1196 118.4 6.62E-106 2.45E+96 0.931888 0.998648 Summary Abnormal findings on diagnostic imaging (HES) T 379101 8914 370187 0.924 -0.078864 0.584628 0.294 2.91 0.892694 0.998648 Summary HESCH Chapter IX Diseases of the circulatory system BIN (HES) T 379101 117038 262063 0.93 -0.072119 0.190176 0.641 1.35 0.704521 0.998648 Summary HESCH Diseases of the ear and mastoid process (HES) T 379101 8809 370292 0.602 -0.506841 0.712051 0.149 2.43 0.476585 0.998648 Summary HESCH Diseases of the nervous system (HES) T 379101 36198 342903 0.871 -0.138663 0.301985 0.482 1.57 0.64611 0.998648 Summary HESCH Mental and behavioural disorders (HES) T 379101 29106 349995 1.02 0.024552 0.314288 0.554 1.9 0.937733 0.998648 Summary HESCH Diseases of the musculo and connec tissue (HES) T 379101 100763 278338 1.26 0.231302 0.183241 0.88 1.8 0.206846 0.998648 Summary HESCH Diseases of the skin and subcutaneous tissue (HES) T 379101 37154 341947 1.1 0.09225 0.273504 0.642 1.87 0.735898 0.998648 Summary HESCH Diseases of the genitourinary system (HES) T 379101 91318 287783 0.945 -0.056343 0.202953 0.635 1.41 0.781306 0.998648 Summary HESCH Diseases of the digestive system (HES) T 379101 137916 241185 1.08 0.074747 0.174499 0.765 1.52 0.668395 0.998648 Summary HESCH Pregnancy childbirth and the puerperium (HES) T 379101 12811 366290 0.583 -0.540169 0.75443 0.133 2.56 0.473994 0.998648 Infectious disease Other bacterial intestinal infections (HES) T 379101 2315 376786 8.33E-05 -9.39326 72.829 8.46E-67 8.20E+57 0.897376 0.998648 Infectious disease Viral and other specified intestinal infections (HES) T 379101 770 378331 9.02E-05 -9.31316 120.69 1.67E-107 4.88E+98 0.938491 0.998648 Infectious disease Streptococcal septicaemia (HES) T 379101 235 378866 0.000104 -9.17306 196.103 1.23E-171 8.76E+162 0.962691 0.998648 Infectious disease Bacterial infection of unspecified site (HES) T 379101 696 378405 3.9 1.36126 1.00506 0.544 28 0.175608 0.998648 Infectious disease Herpesviral (HES) T 379101 232 378869 0.000109 -9.12555 198.698 7.97E-174 1.49E+165 0.963369 0.998648 Infectious disease Viral warts (HES) T 379101 643 378458 0.000105 -9.16035 121.121 8.35E-108 1.32E+99 0.939714 0.998648 Infectious disease Chronic viral hepatitis (HES) T 379101 343 378758 7.65E-05 -9.47852 195.154 5.82E-171 1.00E+162 0.961263 0.998648 Infectious disease Viral infection of unspecified site (HES) T 379101 1590 377511 1.73 0.545373 1.00397 0.241 12.3 0.586982 0.998648 Infectious disease Dermatophytosis (HES) T 379101 227 378874 0.000109 -9.12585 195.35 5.64E-171 2.10E+162 0.96274 0.998648 Infectious disease Streptococcus and staphylococcus (HES) T 379101 3735 375366 0.69 -0.370845 1.00383 0.0965 4.94 0.711807 0.998648 Infectious disease Viral agents as the cause of diseases classified to other chapters (HES) T 379101 505 378596 5.45E-05 -9.81642 194.803 8.26E-171 3.60E+161 0.95981 0.998648 Infectious disease Helicobacter pylori (HES) T 379101 748 378353 0.000101 -9.20198 119.157 3.76E-106 2.70E+97 0.938444 0.998648 Haematology Vitamin B12 deficiency anaemia (HES) T 379101 809 378292 9.19E-05 -9.29465 119.45 1.93E-106 4.38E+97 0.937978 0.998648 Haematology Other aplastic anaemias (HES) T 379101 409 378692 6.32E-05 -9.66951 195.995 9.25E-172 4.31E+162 0.960652 0.998648 Haematology Other anaemias (HES) T 379101 10478 368623 1.05 0.046771 0.507939 0.387 2.84 0.926635 0.998648 Haematology Other coagulation defects (HES) T 379101 874 378227 7.64E-05 -9.47969 121.137 5.88E-108 9.93E+98 0.937624 0.998648 Haematology Purpura and other haemorrhagic conditions (HES) T 379101 1530 377571 4.42E-05 -10.0257 120.326 1.67E-107 1.17E+98 0.933596 0.998648 Haematology Agranulocytosis (HES) T 379101 2906 376195 6.39E-05 -9.6585 73.0767 3.99E-67 1.02E+58 0.89485 0.998648 Haematology Other disorders of white blood cells (HES) T 379101 309 378792 8.27E-05 -9.40052 197.512 6.19E-173 1.10E+164 0.962039 0.998648 Immuno-inflammation Sarcoidosis (HES) T 379101 489 378612 4.91E-05 -9.92227 199.601 6.12E-175 3.93E+165 0.960353 0.998648 Immuno-inflammation Other disorders involving the immune mechanism (HES) T 379101 290 378811 8.84E-05 -9.33325 195.357 4.52E-171 1.73E+162 0.961895 0.998648 Metabolic Other hypothyroidism (HES) T 379101 12869 366232 0.425 -0.856415 0.714756 0.105 1.72 0.230843 0.998648 Metabolic Thyrotoxicosis (HES) T 379101 1663 377438 1.7 0.52781 1.00497 0.236 12.2 0.599443 0.998648 Metabolic Thyroiditis (HES) T 379101 275 378826 0.000105 -9.16501 191.43 1.18E-167 9.29E+158 0.961815 0.998648 Metabolic Other disorders of thyroid (HES) T 379101 357 378744 7.58E-05 -9.48765 195.033 7.31E-171 7.85E+161 0.961201 0.998648 Metabolic Insulin dependent diabetes mellitus (HES) T 379101 2572 376529 1.01 0.012314 1.00411 0.141 7.25 0.990216 0.998648 Metabolic Non insulin dependent diabetes mellitus (HES) T 379101 16601 362500 0.462 -0.771861 0.586078 0.147 1.46 0.187841 0.998648 Metabolic Unspecified diabetes mellitus (HES) T 379101 2120 376981 1.29 0.253916 1.00534 0.18 9.25 0.800604 0.998648 Metabolic Other disorders of pancreatic internal secretion (HES) T 379101 829 378272 8.35E-05 -9.39126 119.701 1.07E-106 6.50E+97 0.937466 0.998648 Metabolic Hyperparathyroidism of parathyroid gland (HES) T 379101 752 378349 3.68 1.30232 1.00568 0.512 26.4 0.195335 0.998648 Metabolic Hyperfunction of pituitary gland (HES) T 379101 291 378810 8.58E-05 -9.36329 198.996 3.51E-174 2.10E+165 0.962471 0.998648 Metabolic Hypofunction and other disorders of pituitary gland (HES) T 379101 359 378742 6.88E-05 -9.5838 198.213 1.30E-173 3.63E+164 0.961437 0.998648 Metabolic Other disorders of adrenal gland (HES) T 379101 431 378670 5.83E-05 -9.75059 199.029 2.23E-174 1.52E+165 0.960927 0.998648 Metabolic Ovarian dysfunction (HES) T 379101 239 378862 5.87E-08 -16.6504 9398.25 0 Inf 0.998586 0.998648 Metabolic Deficiency of other B group vitamins (HES) T 379101 664 378437 0.000108 -9.13663 120.542 2.66E-107 4.36E+98 0.939581 0.998648 Metabolic Vitamin D deficiency (HES) T 379101 359 378742 7.42E-05 -9.50887 198.186 1.48E-173 3.71E+164 0.961733 0.998648 Metabolic Deficiency of other nutrient elements (HES) T 379101 216 378885 0.000108 -9.13344 198.418 1.37E-173 8.52E+164 0.963285 0.998648 Metabolic Obesity (HES) T 379101 9864 369237 1.11 0.100141 0.507522 0.409 2.99 0.843582 0.998648 Metabolic Disorders of porphyrin and bilirubin metabolism (HES) T 379101 367 378734 6.66E-05 -9.61673 196.748 2.23E-172 1.99E+163 0.961016 0.998648 Metabolic Disorders of mineral metabolism (HES) T 379101 1975 377126 1.38 0.324204 1.0047 0.193 9.91 0.746933 0.998648 Metabolic Volume depletion (HES) T 379101 2592 376509 2.13 0.75676 0.713645 0.526 8.63 0.288955 0.998648 Metabolic Other disorders of fluid electrolyte and acid base balance (HES) T 379101 4789 374312 1.72 0.543922 0.585776 0.547 5.43 0.353122 0.998648 Metabolic Postprocedural endocrine and metabolic disorders (HES) T 379101 1206 377895 2.3 0.834428 1.00548 0.321 16.5 0.406608 0.998648 Mental health Dementia in Alzheimer s disease (HES) T 379101 223 378878 5.03E-05 -9.89816 302.275 2.51E-262 1.01E+253 0.973877 0.998648 Mental health Unspecified dementia (HES) T 379101 432 378669 6.75E-05 -9.60267 184.899 2.76E-162 1.66E+153 0.958581 0.998648 Mental health Delirium not induced by alcohol and other psychoactive substances (HES) T 379101 538 378563 5.08E-05 -9.88789 188.995 6.76E-166 3.82E+156 0.958275 0.998648 Mental health Other mental disorders due to brain damage (HES) T 379101 212 378889 0.000119 -9.03281 195.125 9.62E-171 1.48E+162 0.963077 0.998648 Mental health Mental and behavioural disorders due to use of tobacco (HES) T 379101 10134 368967 0.802 -0.22039 0.584502 0.255 2.52 0.706132 0.998648 Mental health Schizophrenia (HES) T 379101 496 378605 5.04E-05 -9.89507 197.294 5.79E-173 4.39E+163 0.96 0.998648 Mental health Bipolar affective disorder (HES) T 379101 888 378213 7.55E-05 -9.4914 121.079 6.51E-108 8.76E+98 0.937518 0.998648 Mental health Depressive episode (HES) T 379101 10665 368436 0.763 -0.270875 0.583772 0.243 2.39 0.642641 0.998648 Mental health Recurrent depressive disorder (HES) T 379101 679 378422 9.97E-05 -9.21352 121.015 9.74E-108 1.02E+99 0.939312 0.998648 Mental health Phobic anxiety disorders (HES) T 379101 527 378574 4.88E-05 -9.92798 198.559 4.69E-174 5.07E+164 0.960122 0.998648 Mental health Other anxiety disorders (HES) T 379101 5413 373688 0.504 -0.685279 1.00361 0.0705 3.6 0.494726 0.998648 Mental health Reaction to severe stress and adjustment disorders (HES) T 379101 481 378620 5.18E-05 -9.86797 197.286 6.04E-173 4.44E+163 0.960108 0.998648 Mental health Somatoform disorders (HES) T 379101 381 378720 6.56E-05 -9.63247 199.301 1.47E-174 2.92E+165 0.961452 0.998648 Mental health Sexual dysfunction not caused disorder or disease (HES) T 379101 264 378837 0.000106 -9.1506 185.43 1.53E-162 7.36E+153 0.960642 0.998648 Mental health Specific personality disorders (HES) T 379101 293 378808 8.61E-05 -9.36048 195.904 1.51E-171 4.92E+162 0.961891 0.998648 Neurosciences Spinal muscular atrophy and related syndromes (HES) T 379101 213 378888 0.000116 -9.05856 195.603 3.68E-171 3.69E+162 0.963062 0.998648 Neurosciences Dystonia (HES) T 379101 231 378870 0.000112 -9.09526 198.656 8.92E-174 1.41E+165 0.963483 0.998648 Neurosciences Other extrapyramidal and movement disorders (HES) T 379101 562 378539 4.52E-05 -10.0047 197.954 1.42E-173 1.44E+164 0.959692 0.998648 Neurosciences Other degenerative diseases of nervous system (HES) T 379101 567 378534 4.53E-05 -10.002 194.108 2.68E-170 7.66E+160 0.958905 0.998648 Neurosciences Multiple sclerosis (HES) T 379101 1215 377886 2.27 0.818044 1.00463 0.316 16.2 0.415487 0.998648 Neurosciences Other demyelinating diseases of CNS (HES) T 379101 283 378818 8.99E-05 -9.31699 198.27 1.52E-173 5.30E+164 0.96252 0.998648 Neurosciences Epilepsy (HES) T 379101 3387 375714 0.792 -0.23279 1.00363 0.111 5.67 0.816577 0.998648 Neurosciences Migraine (HES) T 379101 2516 376585 2.23 0.800667 0.713573 0.55 9.02 0.26184 0.998648 Neurosciences Other headache syndromes (HES) T 379101 459 378642 5.55E-05 -9.79866 199.293 1.27E-174 2.43E+165 0.960786 0.998648 Neurosciences Transient cerebral ischaemic attacks and related syndromes (HES) T 379101 2348 376753 1.15 0.140922 1.00574 0.16 8.27 0.888566 0.998648 Neurosciences Sleep disorders (HES) T 379101 4841 374260 0.525 -0.644634 1.00427 0.0733 3.76 0.520944 0.998648 Neurosciences Disorders of trigeminal nerve (HES) T 379101 419 378682 6.22E-05 -9.68576 197.848 2.41E-173 1.60E+164 0.960955 0.998648 Neurosciences Facial nerve disorders (HES) T 379101 777 378324 8.45E-05 -9.37877 120.828 1.19E-107 5.99E+98 0.938129 0.998648 Neurosciences Nerve root and plexus disorders (HES) T 379101 316 378785 7.74E-05 -9.46712 199.728 7.53E-175 7.95E+165 0.962194 0.998648 Neurosciences Nerve root and plexus compressions (HES) T 379101 3581 375520 0.724 -0.323087 1.00356 0.101 5.18 0.747498 0.998648 Neurosciences Mononeuropathies of upper limb (HES) T 379101 9665 369436 0.273 -1.29945 1.00385 0.0381 1.95 0.195506 0.998648 Neurosciences Mononeuropathies of lower limb (HES) T 379101 1479 377622 4.98E-05 -9.90709 118.589 5.65E-106 4.39E+96 0.933421 0.998648 Neurosciences Other mononeuropathies (HES) T 379101 306 378795 8.22E-05 -9.40617 199.146 2.50E-174 2.70E+165 0.962328 0.998648 Neurosciences Mononeuropathy in diseases classified elsewhere (HES) T 379101 205 378896 0.000126 -8.98302 193.903 1.11E-169 1.42E+161 0.963049 0.998648 Neurosciences Inflammatory polyneuropathy (HES) T 379101 268 378833 9.42E-05 -9.27015 198.155 2.00E-173 4.44E+164 0.962687 0.998648 Neurosciences Other polyneuropathies (HES) T 379101 1097 378004 6.11E-05 -9.70346 119.588 9.78E-107 3.81E+97 0.93533 0.998648 Neurosciences Polyneuropathy in diseases classified elsewhere (HES) T 379101 353 378748 7.02E-05 -9.56419 195.663 1.97E-171 2.50E+162 0.961014 0.998648 Neurosciences Paraplegia and tetraplegia (HES) T 379101 297 378804 8.17E-05 -9.41268 197.625 4.90E-173 1.36E+164 0.962012 0.998648 Neurosciences Other paralytic syndromes (HES) T 379101 334 378767 7.37E-05 -9.51549 199.266 1.77E-174 3.06E+165 0.961913 0.998648 Neurosciences Disorders of autonomic nervous system (HES) T 379101 241 378860 0.000107 -9.14177 197.094 1.82E-172 6.30E+163 0.963005 0.998648 Neurosciences Hydrocephalus (HES) T 379101 402 378699 6.11E-05 -9.70314 199.277 1.44E-174 2.59E+165 0.961165 0.998648 Neurosciences Other disorders of brain (HES) T 379101 1438 377663 4.59E-05 -9.9882 121.177 3.27E-108 6.46E+98 0.934308 0.998648 Neurosciences Other diseases of spinal cord (HES) T 379101 528 378573 4.69E-05 -9.96647 198.088 1.14E-173 1.94E+164 0.959873 0.998648 Neurosciences Other disorders of CNS (HES) T 379101 223 378878 0.00011 -9.11906 199.367 2.16E-174 5.55E+165 0.963517 0.998648 Neurosciences Other nervous system in diseases classified elsewhere (HES) T 379101 960 378141 6.96E-05 -9.57236 120.513 1.82E-107 2.66E+98 0.936691 0.998648 Eye Other inflammation of eyelid (HES) T 379101 538 378563 4.62E-05 -9.98253 197.648 2.65E-173 8.05E+163 0.959719 0.998648 Eye Other disorders of eyelid (HES) T 379101 5168 373933 1.06 0.061289 0.71321 0.263 4.3 0.931518 0.998648 Eye Disorders of lacrimal system (HES) T 379101 1950 377151 3.79E-05 -10.1801 118.683 3.58E-106 4.02E+96 0.931645 0.998648 Eye Disorders of orbit (HES) T 379101 250 378851 9.87E-05 -9.22348 199.46 1.62E-174 6.00E+165 0.963117 0.998648 Eye Conjunctivitis (HES) T 379101 221 378880 0.000116 -9.0599 198.225 2.15E-173 6.28E+164 0.963545 0.998648 Eye Other disorders of conjunctiva (HES) T 379101 672 378429 0.000101 -9.19945 120.482 2.81E-107 3.64E+98 0.939136 0.998648 Eye Keratitis (HES) T 379101 236 378865 0.000103 -9.18234 199.145 3.14E-174 3.37E+165 0.963223 0.998648 Eye Other disorders of iris and ciliary body (HES) T 379101 272 378829 8.61E-05 -9.36047 197.285 1.01E-172 7.37E+163 0.962158 0.998648 Eye Senile cataract (HES) T 379101 7529 371572 1.47 0.387418 0.513961 0.538 4.03 0.450976 0.998648 Eye Other cataract (HES) T 379101 13094 366007 1.27 0.239654 0.423606 0.554 2.92 0.571566 0.998648 Eye Other disorders of lens (HES) T 379101 203 378898 0.000118 -9.04761 197.657 6.63E-173 2.09E+164 0.96349 0.998648 Eye Retinal detachments and breaks (HES) T 379101 2997 376104 0.821 -0.197786 1.00462 0.115 5.88 0.843925 0.998648 Eye Other retinal disorders (HES) T 379101 3106 375995 1.74 0.553908 0.715095 0.428 7.07 0.438579 0.998648 Eye Retinal disorders in diseases classified elsewhere (HES) T 379101 1229 377872 5.47E-05 -9.81361 118.642 5.60E-106 5.35E+96 0.934077 0.998648 Eye Glaucoma (HES) T 379101 4047 375054 1.32 0.276751 0.714777 0.325 5.35 0.698619 0.998648 Eye Disorders of vitreous body (HES) T 379101 1246 377855 2.03 0.709123 1.00524 0.283 14.6 0.480546 0.998648 Eye Disorders of globe (HES) T 379101 389 378712 5.79E-05 -9.7576 196.481 3.27E-172 1.02E+163 0.960392 0.998648 Eye Other disorders of optic (HES) T 379101 285 378816 8.43E-05 -9.38099 197.893 2.99E-173 2.38E+164 0.962191 0.998648 Eye Paralytic strabismus (HES) T 379101 258 378843 9.18E-05 -9.2964 198.58 8.47E-174 9.94E+164 0.962661 0.998648 Eye Other strabismus (HES) T 379101 823 378278 8.16E-05 -9.4142 121.081 7.00E-108 9.50E+98 0.938026 0.998648 Eye Disorders of refraction and accommodation (HES) T 379101 1639 377462 1.56 0.446886 1.00489 0.218 11.2 0.656527 0.998648 Eye Visual disturbances (HES) T 379101 2695 376406 6.72E-05 -9.60795 73.3706 2.36E-67 1.91E+58 0.895814 0.998648 Eye Blindness and low vision (HES) T 379101 805 378296 3.34 1.20596 1.00467 0.466 23.9 0.230005 0.998648 Eye Other disorders of eye and adnexa (HES) T 379101 430 378671 5.93E-05 -9.7332 199.203 1.61E-174 2.18E+165 0.96103 0.998648 ENT Otitis externa (HES) T 379101 488 378613 5.04E-05 -9.89489 199.397 9.39E-175 2.71E+165 0.960422 0.998648 ENT Other disorders of external ear (HES) T 379101 883 378218 7.35E-05 -9.51802 120.327 2.77E-107 1.95E+98 0.936952 0.998648 ENT Nonsuppurative otitis media (HES) T 379101 959 378142 2.77 1.01845 1.00432 0.387 19.8 0.310552 0.998648 ENT Suppurative and unspecified otitis media (HES) T 379101 700 378401 9.91E-05 -9.2196 120.776 1.55E-107 6.35E+98 0.939152 0.998648 ENT Cholesteatoma of middle ear (HES) T 379101 393 378708 6.22E-05 -9.68453 199.242 1.57E-174 2.47E+165 0.961233 0.998648 ENT Perforation of tympanic membrane (HES) T 379101 870 378231 7.91E-05 -9.445 120.935 9.04E-108 6.92E+98 0.937749 0.998648 ENT Other disorders of tympanic membrane (HES) T 379101 333 378768 7.34E-05 -9.51901 199.383 1.41E-174 3.84E+165 0.961922 0.998648 ENT Other disorders of middle ear and mastoid (HES) T 379101 400 378701 6.26E-05 -9.67887 199.298 1.41E-174 2.77E+165 0.961266 0.998648 ENT Otosclerosis (HES) T 379101 275 378826 8.65E-05 -9.35548 199.283 2.01E-174 3.72E+165 0.962556 0.998648 ENT Disorders of vestibular function (HES) T 379101 871 378230 8.10E-05 -9.42128 120.121 4.56E-107 1.44E+98 0.937485 0.998648 ENT Other diseases of inner ear (HES) T 379101 734 378367 9.29E-05 -9.28422 120.813 1.35E-107 6.40E+98 0.938745 0.998648 ENT Conductive and sensorineural hearing loss (HES) T 379101 866 378235 7.70E-05 -9.4714 120.816 1.11E-107 5.34E+98 0.937514 0.998648 ENT Other hearing loss (HES) T 379101 2563 376538 1.02 0.02443 1.00469 0.143 7.34 0.980601 0.998648 ENT Otalgia and effusion of ear (HES) T 379101 479 378622 5.25E-05 -9.85486 199.157 1.56E-174 1.76E+165 0.960534 0.998648 ENT Other disorders of ear (HES) T 379101 566 378535 4.44E-05 -10.0232 198.834 2.49E-174 7.90E+164 0.959796 0.998648 Cardiovascular Rheumatic mitral valve diseases (HES) T 379101 286 378815 9.87E-05 -9.22372 192.592 1.14E-168 8.55E+159 0.961802 0.998648 Cardiovascular Rheumatic tricuspid valve diseases (HES) T 379101 262 378839 9.96E-05 -9.21442 195.011 1.00E-170 9.88E+161 0.962313 0.998648 Cardiovascular Multiple valve diseases (HES) T 379101 1492 377609 4.83E-05 -9.93741 116.909 1.48E-104 1.58E+95 0.93226 0.998648 Cardiovascular Essential primary hypertension (HES) T 379101 70382 308719 0.926 -0.076894 0.227978 0.592 1.45 0.735902 0.998648 Cardiovascular Hypertensive renal disease (HES) T 379101 1396 377705 4.99E-05 -9.90512 117.597 3.96E-105 6.29E+95 0.932874 0.998648 Cardiovascular Acute myocardial infarction (HES) T 379101 7305 371796 0.348 -1.05449 1.00602 0.0485 2.5 0.294559 0.998648 Cardiovascular Subsequent myocardial infarction (HES) T 379101 663 378438 4.03E-05 -10.1188 187.227 1.72E-164 9.47E+154 0.956899 0.998648 Cardiovascular Other acute ischaemic heart diseases (HES) T 379101 1278 377823 5.55E-05 -9.79983 116.337 5.20E-104 5.92E+94 0.932869 0.998648 Cardiovascular Chronic ischaemic heart disease (HES) T 379101 22951 356150 0.543 -0.610109 0.462592 0.219 1.35 0.187205 0.998648 Cardiovascular Pulmonary embolism (HES) T 379101 3296 375805 1.6 0.471255 0.713334 0.396 6.48 0.508845 0.998648 Cardiovascular Other pulmonary heart diseases (HES) T 379101 745 378356 3.59 1.27775 1.00631 0.499 25.8 0.204178 0.998648 Cardiovascular Other diseases of pericardium (HES) T 379101 973 378128 2.69 0.9886 1.00513 0.375 19.3 0.325333 0.998648 Cardiovascular Nonrheumatic aortic valve disorders (HES) T 379101 2314 376787 1.14 0.12939 1.00642 0.158 8.18 0.897702 0.998648 Cardiovascular Cardiomyopathy (HES) T 379101 1163 377938 5.62E-05 -9.78609 118.97 3.02E-106 1.05E+97 0.934443 0.998648 Cardiovascular Atrioventricular and left bundle branch block (HES) T 379101 3286 375815 0.79 -0.236193 1.00611 0.11 5.67 0.814397 0.998648 Cardiovascular Other conduction disorders (HES) T 379101 1981 377120 2.62 0.962985 0.715097 0.645 10.6 0.178093 0.998648 Cardiovascular Cardiac arrest (HES) T 379101 863 378238 3.07 1.12288 1.00642 0.428 22.1 0.264543 0.998648 Cardiovascular Paroxysmal tachycardia (HES) T 379101 2977 376124 1.79 0.580289 0.713112 0.442 7.23 0.415793 0.998648 Cardiovascular Atrial fibrillation and flutter (HES) T 379101 13484 365617 1.61 0.47339 0.372336 0.774 3.33 0.203585 0.998648 Cardiovascular Other cardiac arrhythmias (HES) T 379101 2381 376720 7.84E-05 -9.45305 72.2306 2.57E-66 2.39E+57 0.895876 0.998648 Cardiovascular Heart failure (HES) T 379101 4854 374247 3.99E-05 -10.1296 69.9549 1.13E-64 1.40E+55 0.884868 0.998648 Cardiovascular Complications and ill defined descriptions of heart disease (HES) T 379101 3773 375328 1.41 0.346807 0.715589 0.348 5.75 0.627928 0.998648 Cardiovascular Intracerebral haemorrhage (HES) T 379101 660 378441 0.000104 -9.17099 118.276 2.18E-105 4.96E+96 0.938195 0.998648 Cardiovascular Other nontraumatic intracranial haemorrhage (HES) T 379101 336 378765 7.44E-05 -9.50572 193.041 3.56E-169 1.55E+160 0.960726 0.998648 Cardiovascular Cerebral infarction (HES) T 379101 2917 376184 1.85 0.61645 0.715023 0.456 7.52 0.38861 0.998648 Cardiovascular Stroke not specified as haemorrhage or infarction (HES) T 379101 968 378133 7.30E-05 -9.52544 117.354 9.32E-105 5.71E+95 0.935308 0.998648 Cardiovascular Occlusion and stenosis not cerebral infarction (HES) T 379101 928 378173 8.00E-05 -9.43314 115.013 1.01E-102 6.37E+93 0.934632 0.998648 Cardiovascular Sequelae of cerebrovascular disease (HES) T 379101 1161 377940 2.3 0.831502 1.00533 0.32 16.5 0.408185 0.998648 Cardiovascular Atherosclerosis (HES) T 379101 1127 377974 6.43E-05 -9.65269 115.032 7.77E-103 5.31E+93 0.933125 0.998648 Cardiovascular Arterial embolism and thrombosis (HES) T 379101 839 378262 8.70E-05 -9.3491 116.593 4.94E-104 1.53E+95 0.936089 0.998648 Cardiovascular Other disorders of arteries and arterioles (HES) T 379101 1296 377805 5.61E-05 -9.78899 116.8 2.12E-104 1.48E+95 0.933207 0.998648 Cardiovascular Diseases of capillaries (HES) T 379101 604 378497 0.000116 -9.05851 120.19 5.73E-107 2.36E+98 0.939921 0.998648 Cardiovascular Phlebitis and thrombophlebitis (HES) T 379101 3502 375599 1.5 0.408723 0.713135 0.372 6.09 0.566553 0.998648 Cardiovascular Other venous embolism and thrombosis (HES) T 379101 367 378734 6.64E-05 -9.6198 199.511 9.89E-175 4.46E+165 0.961543 0.998648 Cardiovascular Varicose veins of lower extremities (HES) T 379101 9985 369116 1.12 0.116379 0.507881 0.415 3.04 0.818756 0.998648 Cardiovascular Haemorrhoids (HES) T 379101 21509 357592 1.25 0.226939 0.328284 0.659 2.39 0.489384 0.998648 Digestive system Oesophageal varices (HES) T 379101 488 378613 5.18E-05 -9.86818 195.946 8.35E-172 3.21E+162 0.959834 0.998648 Cardiovascular Varicose veins of other sites (HES) T 379101 460 378641 5.64E-05 -9.78321 193.824 5.82E-170 5.46E+160 0.959744 0.998648 Cardiovascular Other lymphatic vessels and lymph nodes (HES) T 379101 601 378500 0.00011 -9.11425 120.872 1.42E-107 8.51E+98 0.939893 0.998648 Cardiovascular Hypotension (HES) T 379101 4415 374686 1.85 0.612906 0.585389 0.586 5.81 0.295097 0.998648 Cardiovascular Disorders of circulatory system in disease (HES) T 379101 256 378845 9.88E-05 -9.22199 193.677 1.36E-169 7.18E+160 0.962023 0.998648 ENT Acute nasopharyngitis (HES) T 379101 356 378745 6.95E-05 -9.57406 199.128 2.19E-174 2.20E+165 0.961652 0.998648 ENT Acute pharyngitis (HES) T 379101 757 378344 8.98E-05 -9.31841 121.151 6.72E-108 1.20E+99 0.938691 0.998648 ENT Acute tonsillitis (HES) T 379101 512 378589 5.45E-05 -9.81782 193.663 7.71E-170 3.85E+160 0.959568 0.998648 Respiratory Acute upper respiratory infections (HES) T 379101 729 378372 9.37E-05 -9.27525 121.053 8.50E-108 1.03E+99 0.938925 0.998648 Respiratory Pneumonia due to Streptococcus pneumoniae (HES) T 379101 234 378867 0.000109 -9.12683 197.84 4.28E-173 2.76E+164 0.963205 0.998648 Respiratory Bacterial pneumonia (HES) T 379101 433 378668 5.82E-05 -9.75184 196.558 2.83E-172 1.20E+163 0.960431 0.998648 Respiratory Vasomotor and allergic rhinitis (HES) T 379101 952 378149 2.79 1.02776 1.00424 0.39 20 0.306111 0.998648 Respiratory Chronic rhinitis nasopharyngitis and pharyngitis (HES) T 379101 770 378331 8.90E-05 -9.32704 120.898 1.09E-107 7.24E+98 0.938506 0.998648 Respiratory Chronic sinusitis (HES) T 379101 2225 376876 1.21 0.192281 1.00383 0.169 8.67 0.848097 0.998648 Respiratory Chronic diseases of tonsils and adenoids (HES) T 379101 904 378197 7.89E-05 -9.44757 119.164 2.90E-106 2.14E+97 0.936808 0.998648 Respiratory Peritonsillar abscess (HES) T 379101 376 378725 6.98E-05 -9.56933 195.708 1.80E-171 2.72E+162 0.961002 0.998648 Respiratory Diseases of vocal cords and larynx (HES) T 379101 1561 377540 4.51E-05 -10.0074 120.079 2.76E-107 7.36E+97 0.933581 0.998648 Respiratory Other diseases of upper respiratory tract (HES) T 379101 650 378451 0.000102 -9.19331 120.38 3.45E-107 3.00E+98 0.939126 0.998648 Respiratory Bronchitis not specified as acute or chronic (HES) T 379101 570 378531 4.80E-05 -9.94345 197.297 5.48E-173 4.21E+163 0.959805 0.998648 Respiratory Unspecified chronic bronchitis (HES) T 379101 243 378858 0.000121 -9.01596 192.541 1.55E-168 9.52E+159 0.962652 0.998648 Respiratory Asthma (HES) T 379101 23838 355263 1.38 0.324136 0.302217 0.765 2.5 0.283483 0.998648 Respiratory Status asthmaticus (HES) T 379101 233 378868 0.000111 -9.10334 198.551 1.09E-173 1.14E+165 0.963431 0.998648 Respiratory Pulmonary oedema (HES) T 379101 428 378673 6.12E-05 -9.70135 194.672 1.20E-170 3.13E+161 0.960254 0.998648 Respiratory Other interstitial pulmonary diseases (HES) T 379101 930 378171 7.73E-05 -9.46781 117.042 1.82E-104 3.28E+95 0.935528 0.998648 Respiratory Pleural effusion in conditions classified elsewhere (HES) T 379101 225 378876 5.08E-05 -9.88747 308.037 3.16E-267 8.17E+257 0.974394 0.998648 Respiratory Other pleural conditions (HES) T 379101 242 378859 9.89E-05 -9.22166 193.455 2.10E-169 4.65E+160 0.961981 0.998648 Respiratory Postprocedural respiratory disorders (HES) T 379101 334 378767 7.69E-05 -9.473 195.233 5.01E-171 1.18E+162 0.961301 0.998648 Digestive system Embedded and impacted teeth (HES) T 379101 1708 377393 3.96E-05 -10.1361 119.253 1.22E-106 1.28E+97 0.932264 0.998648 Digestive system Dental caries (HES) T 379101 2856 376245 6.15E-05 -9.69688 73.3339 2.32E-67 1.63E+58 0.894803 0.998648 Digestive system Diseases of pulp and periapical tissues (HES) T 379101 2104 376997 1.33 0.285341 1.00394 0.186 9.52 0.776241 0.998648 Digestive system Gingivitis and periodontal diseases (HES) T 379101 766 378335 8.62E-05 -9.3584 120.331 3.22E-107 2.31E+98 0.938009 0.998648 Digestive system Other disorders of gingiva and edentulous alveolar ridge (HES) T 379101 283 378818 9.15E-05 -9.29872 198.395 1.21E-173 6.90E+164 0.962617 0.998648 Digestive system Dentofacial anomalies (HES) T 379101 538 378563 4.68E-05 -9.97014 197.206 6.38E-173 3.43E+163 0.959678 0.998648 Digestive system Other disorders of teeth and supporting structures (HES) T 379101 2410 376691 7.74E-05 -9.46696 73.4023 2.55E-67 2.34E+58 0.897378 0.998648 Digestive system Cysts of oral region (HES) T 379101 377 378724 6.18E-05 -9.69101 199.439 1.06E-174 3.61E+165 0.961245 0.998648 Digestive system Diseases of salivary glands (HES) T 379101 909 378192 3.08 1.12465 1.00434 0.43 22 0.262803 0.998648 Digestive system Stomatitis and related lesions (HES) T 379101 744 378357 9.33E-05 -9.27923 120.979 9.79E-108 8.90E+98 0.938861 0.998648 Digestive system Other diseases of lip and oral mucosa (HES) T 379101 2606 376495 1.06 0.061559 1.00399 0.149 7.61 0.951109 0.998648 Digestive system Diseases of tongue (HES) T 379101 1106 377995 6.13E-05 -9.70025 120.944 6.88E-108 5.46E+98 0.936075 0.998648 Digestive system Oesophagitis (HES) T 379101 8251 370850 0.974 -0.026324 0.584608 0.31 3.06 0.964084 0.998648 Digestive system Gastro oesophageal reflux disease (HES) T 379101 20891 358210 0.764 -0.269064 0.417856 0.337 1.73 0.51963 0.998648 Digestive system Other diseases of oesophagus T 379101 8938 370163 1.21 0.188056 0.509078 0.445 3.27 0.711826 0.998648 Digestive system Gastric ulcer (HES) T 379101 3863 375238 4.92E-05 -9.92012 72.5092 9.35E-67 2.59E+57 0.891179 0.998648 Digestive system Duodenal ulcer (HES) T 379101 2818 376283 1.92 0.654745 0.714426 0.474 7.81 0.359425 0.998648 Digestive system Gastritis and duodenitis (HES) T 379101 26187 352914 1.07 0.064288 0.329561 0.559 2.03 0.845337 0.998648 Digestive system Dyspepsia (HES) T 379101 10739 368362 1.03 0.030031 0.507889 0.381 2.79 0.952849 0.998648 Digestive system Other diseases of stomach and duodenum (HES) T 379101 6601 372500 1.27 0.239654 0.58462 0.404 4 0.681857 0.998648 Digestive system Acute appendicitis (HES) T 379101 2629 376472 0.986 -0.014198 1.00385 0.138 7.05 0.988715 0.998648 Digestive system Other diseases of appendix (HES) T 379101 242 378859 1.00E-04 -9.20969 199.186 2.82E-174 3.55E+165 0.963122 0.998648 Digestive system Inguinal hernia (HES) T 379101 14392 364709 1.21 0.18674 0.398329 0.552 2.63 0.639207 0.998648 Digestive system Femoral hernia (HES) T 379101 558 378543 4.79E-05 -9.94704 196.59 2.18E-172 1.05E+163 0.959646 0.998648 Digestive system Umbilical hernia (HES) T 379101 3437 375664 0.721 -0.326648 1.00477 0.101 5.17 0.745108 0.998648 Digestive system Ventral hernia (HES) T 379101 3093 376008 5.86E-05 -9.7448 73.2314 2.70E-67 1.27E+58 0.894139 0.998648 Digestive system Diaphragmatic hernia (HES) T 379101 24453 354648 0.658 -0.418091 0.418612 0.29 1.5 0.317913 0.998648 Digestive system Unspecified abdominal hernia (HES) T 379101 276 378825 8.96E-05 -9.31964 196.604 3.98E-172 2.02E+163 0.962192 0.998648 Digestive system Crohn s disease (HES) T 379101 1547 377554 4.31E-05 -10.0528 121.213 2.85E-108 6.50E+98 0.933903 0.998648 Digestive system Ulcerative colitis (HES) T 379101 2940 376161 6.09E-05 -9.70647 73.3589 2.19E-67 1.69E+58 0.894735 0.998648 Digestive system Other noninfective gastroenteritis and colitis (HES) T 379101 14793 364308 0.92 -0.083645 0.455709 0.377 2.25 0.854368 0.998648 Digestive system Vascular disorders of intestine (HES) T 379101 936 378165 7.47E-05 -9.50222 118.86 4.98E-106 1.12E+97 0.936281 0.998648 Digestive system Paralytic ileus and intestinal obstruction without hernia (HES) T 379101 3590 375511 0.762 -0.271332 1.0042 0.107 5.46 0.787008 0.998648 Digestive system Diverticular disease of intestine (HES) T 379101 24930 354171 1.11 0.103303 0.331781 0.579 2.12 0.755528 0.998648 Digestive system Irritable bowel syndrome (HES) T 379101 5022 374079 1.13 0.119489 0.713248 0.278 4.56 0.866955 0.998648 Digestive system Other functional intestinal disorders (HES) T 379101 10172 368929 0.54 -0.616945 0.712208 0.134 2.18 0.386357 0.998648 Digestive system Fissure and fistula of anal and rectal regions (HES) T 379101 2863 376238 0.91 -0.094473 1.00401 0.127 6.51 0.925033 0.998648 Digestive system Abscess of anal and rectal regions (HES) T 379101 1208 377893 5.57E-05 -9.79516 119.396 1.30E-106 2.39E+97 0.934615 0.998648 Digestive system Other diseases of intestine (HES) T 379101 13086 366015 0.816 -0.202868 0.508795 0.301 2.21 0.690097 0.998648 Digestive system Peritonitis (HES) T 379101 722 378379 3.77 1.32644 1.00477 0.526 27 0.186788 0.998648 Digestive system Other disorders of peritoneum (HES) T 379101 2824 376277 1.96 0.671119 0.712703 0.484 7.91 0.346371 0.998648 Digestive system Alcoholic liver disease (HES) T 379101 799 378302 3.36 1.21056 1.0077 0.466 24.2 0.229632 0.998648 Digestive system Hepatic failure (HES) T 379101 298 378803 8.56E-05 -9.36573 196.459 5.05E-172 1.45E+163 0.961977 0.998648 Digestive system Other inflammatory liver diseases (HES) T 379101 623 378478 0.000112 -9.09595 120.386 3.76E-107 3.34E+98 0.939772 0.998648 Digestive system Cholecystitis (HES) T 379101 2442 376659 7.73E-05 -9.46812 73.0198 5.40E-67 1.11E+58 0.896831 0.998648 Digestive system Other diseases of biliary tract (HES) T 379101 1752 377349 3.95E-05 -10.139 119.958 3.06E-107 5.09E+97 0.932642 0.998648 Digestive system Intestinal malabsorption (HES) T 379101 1888 377213 3.51E-05 -10.2575 120.633 7.25E-108 1.70E+98 0.932237 0.998648 Digestive system Postprocedural disorders of digestive system (HES) T 379101 1429 377672 1.85 0.614188 1.0043 0.258 13.2 0.540831 0.998648 Digestive system Other diseases of digestive system (HES) T 379101 8428 370673 1.28 0.246447 0.507798 0.473 3.46 0.627446 0.998648 Immuno-inflammation Cutaneous abscess furuncle and carbuncle (HES) T 379101 2145 376956 1.25 0.220728 1.00396 0.174 8.92 0.825983 0.998648 Immuno-inflammation Cellulitis (HES) T 379101 6570 372531 1.61 0.477069 0.508198 0.595 4.36 0.347861 0.998648 Immuno-inflammation Pilonidal cyst (HES) T 379101 452 378649 5.75E-05 -9.7643 192.941 3.35E-169 9.87E+159 0.959638 0.998648 Immuno-inflammation Other local infections of skin and subcutaneous tissue (HES) T 379101 1106 377995 6.10E-05 -9.70391 120.457 1.78E-107 2.09E+98 0.935793 0.998648 Immuno-inflammation Dermatitis due to substances taken internally (HES) T 379101 436 378665 5.84E-05 -9.74799 198.916 2.79E-174 1.22E+165 0.960915 0.998648 Immuno-inflammation Other dermatitis (HES) T 379101 1379 377722 4.91E-05 -9.92178 120.983 5.11E-108 4.72E+98 0.934639 0.998648 Immuno-inflammation Psoriasis (HES) T 379101 2058 377043 1.31 0.266626 1.00406 0.182 9.34 0.790587 0.998648 Immuno-inflammation Lichen planus (HES) T 379101 501 378600 5.64E-05 -9.78273 196.969 1.22E-172 2.60E+163 0.960388 0.998648 Immuno-inflammation Urticaria (HES) T 379101 328 378773 7.69E-05 -9.47304 199.396 1.43E-174 4.12E+165 0.962108 0.998648 Immuno-inflammation Other erythematous conditions (HES) T 379101 481 378620 5.28E-05 -9.84945 198.611 4.59E-174 6.07E+164 0.960448 0.998648 Immuno-inflammation Skin changes due to chronic exposure to nonionizing radiation (HES) T 379101 2179 376922 8.62E-05 -9.35905 71.3434 1.61E-65 4.61E+56 0.895631 0.998648 Immuno-inflammation Rosacea (HES) T 379101 277 378824 9.31E-05 -9.282 197.559 6.36E-173 1.36E+164 0.962527 0.998648 Immuno-inflammation Follicular cysts of skin and subcutaneous tissue (HES) T 379101 7583 371518 0.354 -1.03957 1.00351 0.0495 2.53 0.300233 0.998648 Immuno-inflammation Other follicular disorders (HES) T 379101 373 378728 7.25E-05 -9.53256 198.233 1.32E-173 3.98E+164 0.961646 0.998648 Immuno-inflammation Other disorders of pigmentation (HES) T 379101 706 378395 9.46E-05 -9.26604 120.531 2.39E-107 3.75E+98 0.938722 0.998648 Immuno-inflammation Seborrhoeic keratosis (HES) T 379101 2813 376288 0.976 -0.023973 1.00443 0.136 6.99 0.980958 0.998648 Immuno-inflammation Corns and callosities (HES) T 379101 257 378844 0.00011 -9.11907 194.93 1.29E-170 9.28E+161 0.962688 0.998648 Immuno-inflammation Other epidermal thickening (HES) T 379101 608 378493 4.21E-05 -10.0757 196.764 1.37E-172 1.30E+163 0.95916 0.998648 Immuno-inflammation Atrophic disorders of skin (HES) T 379101 2542 376559 1.07 0.066131 1.00424 0.149 7.65 0.947496 0.998648 Immuno-inflammation Hypertrophic disorders of skin (HES) T 379101 1003 378098 6.82E-05 -9.59275 120.986 7.06E-108 6.60E+98 0.936803 0.998648 Immuno-inflammation Other disorders of skin and subcutaneous tissue (HES) T 379101 5075 374026 1.06 0.062258 0.712557 0.263 4.3 0.930375 0.998648 Musculoskeletal Pyogenic arthritis (HES) T 379101 335 378766 7.08E-05 -9.5556 198.119 1.61E-173 3.11E+164 0.961532 0.998648 Musculoskeletal Seropositive rheumatoid arthritis (HES) T 379101 529 378572 5.13E-05 -9.87741 195.746 1.22E-171 2.15E+162 0.959756 0.998648 Musculoskeletal Other rheumatoid arthritis (HES) T 379101 3989 375112 4.99E-05 -9.90624 72.3742 1.23E-66 2.01E+57 0.891129 0.998648 Musculoskeletal Gout (HES) T 379101 2920 376181 1.75 0.560092 0.717425 0.429 7.14 0.43498 0.998648 Musculoskeletal Other crystal arthropathies (HES) T 379101 369 378732 6.62E-05 -9.62235 194.898 8.33E-171 5.27E+161 0.960624 0.998648 Musculoskeletal Other arthritis (HES) T 379101 10538 368563 0.803 -0.218942 0.585373 0.255 2.53 0.708389 0.998648 Musculoskeletal Polyarthrosis (HES) T 379101 3571 375530 0.833 -0.183293 1.00538 0.116 5.97 0.855338 0.998648 Musculoskeletal Coxarthrosis (HES) T 379101 10780 368321 1.28 0.24356 0.458933 0.519 3.14 0.595619 0.998648 Musculoskeletal Gonarthrosis (HES) T 379101 18217 360884 0.721 -0.327682 0.45696 0.294 1.76 0.473318 0.998648 Musculoskeletal Arthrosis of first carpometacarpal joint (HES) T 379101 1179 377922 2.42 0.883509 1.00573 0.337 17.4 0.379685 0.998648 Musculoskeletal Other arthrosis (HES) T 379101 14991 364110 0.734 -0.309906 0.509195 0.27 1.99 0.542777 0.998648 Musculoskeletal Acquired deformities of fingers and toes (HES) T 379101 8762 370339 0.982 -0.018648 0.587282 0.31 3.1 0.974669 0.998648 Musculoskeletal Other acquired deformities of limbs (HES) T 379101 1540 377561 1.72 0.544803 1.00436 0.241 12.3 0.587518 0.998648 Musculoskeletal Disorders of patella (HES) T 379101 841 378260 3.03 1.10838 1.00467 0.423 21.7 0.26993 0.998648 Musculoskeletal Internal derangement of knee (HES) T 379101 13926 365175 1.31 0.26929 0.388118 0.612 2.8 0.487786 0.998648 Musculoskeletal Other specific joint derangements (HES) T 379101 2363 376738 2.22 0.79674 0.712578 0.549 8.97 0.26352 0.998648 Musculoskeletal Other joint disorders (HES) T 379101 11928 367173 1.14 0.128521 0.455565 0.466 2.78 0.777856 0.998648 Musculoskeletal Systemic lupus erythematosus (HES) T 379101 324 378777 9.35E-05 -9.27806 192.945 5.40E-169 1.62E+160 0.961647 0.998648 Musculoskeletal Other systemic involvement of connective tissue (HES) T 379101 1710 377391 4.33E-05 -10.0476 117.454 4.54E-105 4.12E+95 0.931828 0.998648 Musculoskeletal Scoliosis (HES) T 379101 942 378159 2.96 1.08655 1.00584 0.413 21.3 0.280032 0.998648 Musculoskeletal Ankylosing spondylitis (HES) T 379101 573 378528 4.30E-05 -10.0553 197.173 6.25E-173 2.95E+163 0.959328 0.998648 Musculoskeletal Other inflammatory spondylopathies (HES) T 379101 1156 377945 6.43E-05 -9.65244 119.845 6.22E-107 6.64E+97 0.935807 0.998648 Musculoskeletal Spondylosis (HES) T 379101 6891 372210 0.813 -0.207452 0.71323 0.201 3.29 0.771157 0.998648 Musculoskeletal Other spondylopathies (HES) T 379101 3685 375416 0.724 -0.32256 1.00453 0.101 5.19 0.74813 0.998648 Musculoskeletal Cervical disc disorders (HES) T 379101 1357 377744 4.94E-05 -9.91625 121.149 3.71E-108 6.57E+98 0.934765 0.998648 Musculoskeletal Other intervertebral disc disorders (HES) T 379101 6634 372467 0.802 -0.221108 0.712239 0.198 3.24 0.756225 0.998648 Musculoskeletal Other dorsopathies (HES) T 379101 482 378619 5.36E-05 -9.83425 197.221 7.10E-173 4.05E+163 0.960231 0.998648 Musculoskeletal Dorsalgia (HES) T 379101 13010 366091 0.834 -0.181513 0.507375 0.309 2.25 0.720532 0.998648 Musculoskeletal Myositis (HES) T 379101 207 378894 0.000119 -9.03912 198.312 1.85E-173 7.60E+164 0.963645 0.998648 Musculoskeletal Other disorders of muscle (HES) T 379101 806 378295 3.39 1.21936 1.00461 0.473 24.2 0.224838 0.998648 Musculoskeletal Synovitis and tenosynovitis (HES) T 379101 4728 374373 0.561 -0.57823 1.00373 0.0784 4.01 0.56456 0.998648 Musculoskeletal Spontaneous rupture of synovium and tendon (HES) T 379101 488 378613 4.87E-05 -9.92906 198.231 8.92E-174 2.66E+164 0.960052 0.998648 Musculoskeletal Other disorders of synovium and tendon (HES) T 379101 3447 375654 1.59 0.464338 0.7125 0.394 6.43 0.514593 0.998648 Musculoskeletal Other bursopathies (HES) T 379101 729 378372 9.40E-05 -9.272 120.361 3.31E-107 2.67E+98 0.938596 0.998648 Musculoskeletal Fibroblastic disorders (HES) T 379101 3613 375488 5.19E-05 -9.86655 70.8475 2.56E-65 1.05E+56 0.889241 0.998648 Musculoskeletal Shoulder lesions (HES) T 379101 8336 370765 0.635 -0.454242 0.711889 0.157 2.56 0.523422 0.998648 Musculoskeletal Enthesopathies of lower limb excluding foot (HES) T 379101 393 378708 6.31E-05 -9.67147 199.601 7.87E-175 5.05E+165 0.961354 0.998648 Musculoskeletal Other enthesopathies (HES) T 379101 1540 377561 1.76 0.564248 1.00415 0.246 12.6 0.574174 0.998648 Musculoskeletal Osteoporosis with pathological fracture (HES) T 379101 834 378267 8.60E-05 -9.36104 117.861 4.07E-105 1.82E+96 0.936695 0.998648 Musculoskeletal Disorders of continuity of bone (HES) T 379101 1398 377703 4.75E-05 -9.95563 121.154 3.53E-108 6.38E+98 0.934509 0.998648 Musculoskeletal Other disorders of bone density and structure (HES) T 379101 998 378103 7.71E-05 -9.47002 118.206 1.85E-105 3.21E+96 0.936146 0.998648 Musculoskeletal Osteomyelitis (HES) T 379101 486 378615 5.18E-05 -9.868 197.301 5.87E-173 4.57E+163 0.96011 0.998648 Musculoskeletal Osteonecrosis (HES) T 379101 512 378589 4.93E-05 -9.91713 198.889 2.48E-174 9.79E+164 0.960232 0.998648 Musculoskeletal Paget s disease of bone (HES) T 379101 243 378858 0.000108 -9.13477 196.032 1.47E-171 7.92E+162 0.962833 0.998648 Musculoskeletal Osteopathies in diseases classified elsewhere (HES) T 379101 292 378809 8.53E-05 -9.36889 198.291 1.39E-173 5.25E+164 0.962315 0.998648 Musculoskeletal Other osteochondropathies (HES) T 379101 239 378862 9.34E-05 -9.27867 197.391 8.87E-173 9.84E+163 0.962508 0.998648 Musculoskeletal Other disorders of cartilage (HES) T 379101 677 378424 9.75E-05 -9.23515 120.947 1.09E-107 8.74E+98 0.939135 0.998648 Musculoskeletal Acquired deformities of musculoskeletal (HES) T 379101 329 378772 8.02E-05 -9.43094 197.336 8.48E-173 7.59E+163 0.961883 0.998648 Musculoskeletal Postprocedural musculoskeletal disorders (HES) T 379101 412 378689 6.03E-05 -9.71652 199.219 1.59E-174 2.28E+165 0.9611 0.998648 Genitourinary Recurrent and persistent haematuria (HES) T 379101 660 378441 0.000104 -9.17489 119.532 1.85E-106 5.80E+97 0.938817 0.998648 Genitourinary Chronic nephritic syndrome (HES) T 379101 791 378310 9.14E-05 -9.30057 116.8 3.46E-104 2.42E+95 0.936533 0.998648 Genitourinary Unspecified nephritic syndrome (HES) T 379101 244 378857 0.000102 -9.1879 197.338 1.08E-172 9.71E+163 0.962865 0.998648 Genitourinary Glomerular disorders in diseases classified elsewhere (HES) T 379101 293 378808 8.50E-05 -9.37305 197.094 1.44E-172 5.00E+163 0.96207 0.998648 Genitourinary Tubulo interstitial nephritis not specified as acute or chronic (HES) T 379101 837 378264 8.66E-05 -9.35425 119.91 7.38E-107 1.02E+98 0.93782 0.998648 Genitourinary Obstructive and reflux uropathy (HES) T 379101 2412 376689 1.08 0.0781 1.00432 0.151 7.74 0.938016 0.998648 Genitourinary Acute renal failure (HES) T 379101 4117 374984 1.98 0.683791 0.587341 0.627 6.27 0.244337 0.998648 Genitourinary Chronic renal failure (HES) T 379101 4070 375031 4.74E-05 -9.95752 71.0556 1.56E-65 1.44E+56 0.888552 0.998648 Genitourinary Unspecified renal failure (HES) T 379101 1276 377825 2.11 0.744374 1.00582 0.293 15.1 0.459257 0.998648 Genitourinary Calculus of kidney and ureter (HES) T 379101 4404 374697 4.04E-05 -10.1157 72.3913 9.68E-67 1.69E+57 0.888868 0.998648 Genitourinary Calculus of lower urinary tract (HES) T 379101 726 378375 9.67E-05 -9.24371 115.174 8.86E-103 1.06E+94 0.936032 0.998648 Genitourinary Unspecified renal colic (HES) T 379101 1752 377349 3.75E-05 -10.1903 119.622 5.62E-107 2.50E+97 0.932112 0.998648 Genitourinary Other disorders of kidney and ureter (HES) T 379101 2178 376923 8.44E-05 -9.3804 72.1904 3.00E-66 2.38E+57 0.896614 0.998648 Genitourinary Cystitis (HES) T 379101 2647 376454 1.06 0.060052 1.00453 0.148 7.61 0.95233 0.998648 Genitourinary Neuromuscular dysfunction of bladder (HES) T 379101 1508 377593 1.89 0.636192 1.0046 0.264 13.5 0.526552 0.998648 Genitourinary Other disorders of bladder (HES) T 379101 8086 371015 1.61 0.476428 0.45924 0.655 3.96 0.299536 0.998648 Genitourinary Urethral stricture (HES) T 379101 2967 376134 0.883 -0.124199 1.0044 0.123 6.32 0.901589 0.998648 Genitourinary Other disorders of urethra (HES) T 379101 692 378409 9.86E-05 -9.22396 119.861 9.25E-107 1.05E+98 0.938659 0.998648 Genitourinary Other disorders of urinary system (HES) T 379101 17515 361586 0.947 -0.054301 0.418736 0.417 2.15 0.896821 0.998648 Genitourinary Inflammatory diseases of prostate (HES) T 379101 1436 377665 1.7 0.531593 1.00952 0.235 12.3 0.598485 0.998648 Genitourinary Other disorders of prostate (HES) T 379101 1235 377866 5.88E-08 -16.6491 3547.2 0 Inf 0.996255 0.998648 Genitourinary Hydrocele and spermatocele (HES) T 379101 1221 377880 5.49E-08 -16.7175 3645.35 0 Inf 0.996341 0.998648 Genitourinary Orchitis and epididymitis (HES) T 379101 769 378332 3.18 1.15827 1.00798 0.442 23 0.250513 0.998648 Genitourinary Redundant prepuce phimosis and paraphimosis (HES) T 379101 1890 377211 3.53E-08 -17.1592 3654.34 0 Inf 0.996253 0.998648 Genitourinary Other disorders of penis (HES) T 379101 1896 377205 3.75E-05 -10.192 110.294 4.89E-99 2.87E+89 0.926374 0.998648 Genitourinary Benign mammary dysplasia (HES) T 379101 1624 377477 5.45E-05 -9.81817 110.889 2.22E-99 1.34E+90 0.929447 0.998648 Genitourinary Inflammatory disorders of breast (HES) T 379101 430 378671 7.26E-05 -9.52996 187.019 4.65E-164 1.13E+155 0.95936 0.998648 Genitourinary Hypertrophy of breast (HES) T 379101 719 378382 0.000106 -9.15208 119.215 3.53E-106 3.19E+97 0.938807 0.998648 Genitourinary Unspecified lump in breast (HES) T 379101 1403 377698 6.15E-05 -9.69727 112.239 1.77E-100 2.13E+91 0.93115 0.998648 Genitourinary Other disorders of breast (HES) T 379101 1110 377991 2.62 0.964691 1.00767 0.364 18.9 0.33839 0.998648 Genitourinary Salpingitis and oophoritis (HES) T 379101 472 378629 6.46E-08 -16.5548 5955.72 0 Inf 0.997782 0.998648 Genitourinary Inflammatory disease of uterus except cervix (HES) T 379101 260 378841 1.19E-07 -15.9463 5977.54 0 Inf 0.997871 0.998648 Genitourinary Inflammatory disease of cervix uteri (HES) T 379101 1044 378057 7.70E-08 -16.3796 3631.58 0 Inf 0.996401 0.998648 Genitourinary Other female pelvic inflammatory diseases (HES) T 379101 2493 376608 2.42 0.883426 0.719734 0.59 9.92 0.21966 0.998648 Genitourinary Other inflammation of vagina and vulva (HES) T 379101 690 378411 4.37E-08 -16.9467 6017.17 0 Inf 0.997753 0.998648 Genitourinary Vulvovaginal ulceration and inflammation (HES) T 379101 202 378899 5.91E-08 -16.6447 9824.75 0 Inf 0.998648 0.998648 Genitourinary Endometriosis (HES) T 379101 3557 375544 6.54E-08 -16.5429 2172.91 0 Inf 0.993926 0.998648 Genitourinary Female genital prolapse (HES) T 379101 10411 368690 0.269 -1.31134 1.00816 0.0374 1.94 0.19335 0.998648 Genitourinary Noninflammatory ovary fallop (HES) T 379101 4666 374435 4.69E-08 -16.8758 2195.01 0 Inf 0.993866 0.998648 Genitourinary Polyp of female genital tract (HES) T 379101 9793 369308 1.49 0.396364 0.464129 0.598 3.69 0.393107 0.998648 Genitourinary Other noninflammatory disorders of uterus except cervix (HES) T 379101 4717 374384 4.48E-08 -16.9215 2205.74 0 Inf 0.993879 0.998648 Genitourinary Erosion and ectropion of cervix uteri (HES) T 379101 830 378271 1.00E-07 -16.114 3558.13 0 Inf 0.996387 0.998648 Genitourinary Dysplasia of cervix uteri (HES) T 379101 1404 377697 5.97E-08 -16.6338 3608.08 0 Inf 0.996322 0.998648 Genitourinary Other noninflammatory disorders of cervix uteri (HES) T 379101 1621 377480 1.78 0.577471 1.00785 0.247 12.8 0.566663 0.998648 Genitourinary Other noninflammatory disorders of vagina (HES) T 379101 1392 377709 6.08E-05 -9.70856 110.219 9.19E-99 4.02E+89 0.929809 0.998648 Genitourinary Other noninflammatory disorders of vulva and perineum (HES) T 379101 1719 377382 1.74 0.556652 1.00758 0.242 12.6 0.580629 0.998648 Genitourinary Excessive frequent and irregular menstruation (HES) T 379101 11974 367127 1.02 0.016792 0.520058 0.367 2.82 0.974242 0.998648 Genitourinary Other abnormal uterine and vaginal bleeding (HES) T 379101 3736 375365 1.67 0.511886 0.718865 0.408 6.83 0.476418 0.998648 Genitourinary Pain with female genital (HES) T 379101 3073 376028 7.53E-08 -16.4015 2164.36 0 Inf 0.993954 0.998648 Genitourinary Menopausal and other perimenopausal disorders (HES) T 379101 9413 369688 0.607 -0.498599 0.719649 0.148 2.49 0.488412 0.998648 Genitourinary Female infertility (HES) T 379101 923 378178 5.84E-08 -16.6556 5491.54 0 Inf 0.99758 0.998648 Genitourinary Postprocedural disorders of genitourinary system (HES) T 379101 1063 378038 6.63E-05 -9.62131 118.654 6.63E-106 6.64E+96 0.935373 0.998648 Gynaecology and Obstetrics Ectopic pregnancy (HES) T 379101 264 378837 8.77E-08 -16.2489 8918.05 0 Inf 0.998546 0.998648 Gynaecology and Obstetrics Other abnormal products of conception (HES) T 379101 1191 377910 4.67E-05 -9.97171 165.918 2.74E-146 7.97E+136 0.952076 0.998648 Gynaecology and Obstetrics Spontaneous abortion (HES) T 379101 1258 377843 1.08E-07 -16.0433 3332.68 0 Inf 0.996159 0.998648 Gynaecology and Obstetrics Gestational hypertension without significant proteinuria (HES) T 379101 427 378674 5.07E-08 -16.797 8807.67 0 Inf 0.998478 0.998648 Gynaecology and Obstetrics Gestational hypertension with significant proteinuria (HES) T 379101 289 378812 7.46E-08 -16.4105 8877.31 0 Inf 0.998525 0.998648 Gynaecology and Obstetrics Unspecified maternal hypertension (HES) T 379101 540 378561 1.10E-07 -16.0232 5337.75 0 Inf 0.997605 0.998648 Gynaecology and Obstetrics Haemorrhage in early pregnancy (HES) T 379101 836 378265 7.74E-08 -16.3746 5369.23 0 Inf 0.997567 0.998648 Gynaecology and Obstetrics Excessive vomiting in pregnancy (HES) T 379101 202 378899 1.13E-07 -15.9969 8827.78 0 Inf 0.998554 0.998648 Gynaecology and Obstetrics Infections of genitourinary tract in pregnancy (HES) T 379101 212 378889 1.24E-07 -15.9038 8726.66 0 Inf 0.998546 0.998648 Gynaecology and Obstetrics Maternal care for related to pregnancy (HES) T 379101 1641 377460 1.03E-07 -16.093 3231.98 0 Inf 0.996027 0.998648 Gynaecology and Obstetrics Multiple gestation (HES) T 379101 258 378843 8.59E-08 -16.2705 8796.48 0 Inf 0.998524 0.998648 Gynaecology and Obstetrics Maternal care for known or suspected malpresentation of fetus (HES) T 379101 990 378111 5.99E-08 -16.6309 5313.48 0 Inf 0.997503 0.998648 Gynaecology and Obstetrics Maternal care for known or suspected abnormality of pelvic organs (HES) T 379101 1384 377717 4.13E-08 -17.0026 5338.78 0 Inf 0.997459 0.998648 Gynaecology and Obstetrics Maternal care fetal abnormality and damage (HES) T 379101 238 378863 9.18E-08 -16.2035 8892.25 0 Inf 0.998546 0.998648 Gynaecology and Obstetrics Maternal care for other known or suspected fetal problems (HES) T 379101 1716 377385 9.51E-08 -16.1682 3220.73 0 Inf 0.995995 0.998648 Gynaecology and Obstetrics Other disorders of amniotic fluid and membranes (HES) T 379101 236 378865 8.64E-08 -16.2647 8810.36 0 Inf 0.998527 0.998648 Gynaecology and Obstetrics Premature rupture of membranes (HES) T 379101 1011 378090 6.22E-08 -16.5924 5279.74 0 Inf 0.997493 0.998648 Gynaecology and Obstetrics Placental disorders (HES) T 379101 225 378876 1.09E-07 -16.0276 8711.78 0 Inf 0.998532 0.998648 Gynaecology and Obstetrics Antepartum haemorrhage (HES) T 379101 588 378513 1.00E-07 -16.1178 5324.11 0 Inf 0.997585 0.998648 Gynaecology and Obstetrics False labour (HES) T 379101 973 378128 6.47E-08 -16.5538 5290.43 0 Inf 0.997503 0.998648 Gynaecology and Obstetrics Prolonged pregnancy (HES) T 379101 1102 377999 5.49E-08 -16.7182 5323.05 0 Inf 0.997494 0.998648 Gynaecology and Obstetrics Preterm delivery (HES) T 379101 602 378499 1.04E-07 -16.0817 5350.17 0 Inf 0.997602 0.998648 Gynaecology and Obstetrics Abnormalities of forces of labour (HES) T 379101 405 378696 5.80E-08 -16.6636 8759.15 0 Inf 0.998482 0.998648 Gynaecology and Obstetrics Long labour (HES) T 379101 1773 377328 9.76E-08 -16.1427 3188.33 0 Inf 0.99596 0.998648 Gynaecology and Obstetrics Obstructed labour malpresentation of fetus (HES) T 379101 382 378719 6.38E-08 -16.5678 8800.67 0 Inf 0.998498 0.998648 Gynaecology and Obstetrics Other obstructed labour (HES) T 379101 309 378792 7.56E-08 -16.3972 8740.77 0 Inf 0.998503 0.998648 Gynaecology and Obstetrics Labour and delivery complicated by fetal stress (HES) T 379101 3031 376070 1.49 0.400899 1.03342 0.197 11.3 0.698065 0.998648 Gynaecology and Obstetrics Labour and delivery complicated by umbilical cord complications (HES) T 379101 570 378531 9.17E-08 -16.2042 5413.19 0 Inf 0.997612 0.998648 Gynaecology and Obstetrics Perineal laceration during delivery (HES) T 379101 4945 374156 0.896 -0.109482 1.03505 0.118 6.82 0.915761 0.998648 Gynaecology and Obstetrics Postpartum haemorrhage (HES) T 379101 1204 377897 5.25E-08 -16.7623 5299.5 0 Inf 0.997476 0.998648 Gynaecology and Obstetrics Retained placenta and membranes without haemorrhage (HES) T 379101 203 378898 1.01E-07 -16.1076 8889.16 0 Inf 0.998554 0.998648 Gynaecology and Obstetrics Other complications of labour and delivery (HES) T 379101 696 378405 9.05E-08 -16.2179 5336.12 0 Inf 0.997575 0.998648 Gynaecology and Obstetrics Single spontaneous delivery (HES) T 379101 1836 377265 8.55E-08 -16.2745 3233.88 0 Inf 0.995985 0.998648 Gynaecology and Obstetrics Single delivery by caesarean section (HES) T 379101 504 378597 1.00E-07 -16.116 5393.15 0 Inf 0.997616 0.998648 Gynaecology and Obstetrics Other maternal diseases complicating pregnancy (HES) T 379101 1582 377519 3.15 1.14688 1.03119 0.417 23.8 0.266057 0.998648 Genitourinary Cystic kidney disease (HES) T 379101 414 378687 5.88E-05 -9.74063 198.465 6.81E-174 5.09E+164 0.960856 0.998648 Genitourinary Other congenital malformations of kidney (HES) T 379101 214 378887 0.000111 -9.10409 199.125 3.53E-174 3.51E+165 0.963533 0.998648 Symptoms Abnormalities of heart beat (HES) T 379101 7716 371385 0.7 -0.356262 0.712812 0.173 2.83 0.617218 0.998648 Symptoms Cardiac murmurs and other cardiac sounds (HES) T 379101 965 378136 7.19E-05 -9.53983 119.924 5.96E-107 8.68E+97 0.936596 0.998648 Symptoms Abnormal blood pressure reading without diagnosis (HES) T 379101 2292 376809 8.02E-05 -9.43064 72.7625 9.28E-67 6.93E+57 0.896876 0.998648 Symptoms Cough (HES) T 379101 2614 376487 2.13 0.757831 0.712989 0.527 8.63 0.28783 0.998648 Symptoms Abnormalities of breathing (HES) T 379101 8413 370688 1.64 0.494835 0.456225 0.671 4.01 0.278085 0.998648 Symptoms Pain in throat and chest (HES) T 379101 28963 350138 0.829 -0.187731 0.345183 0.421 1.63 0.586538 0.998648 Symptoms Symptoms the circulatory and respiratory systems (HES) T 379101 1000 378101 6.76E-05 -9.60177 120.74 1.13E-107 4.04E+98 0.936616 0.998648 Symptoms Abdominal and pelvic pain (HES) T 379101 28298 350803 1.08 0.08056 0.314486 0.585 2.01 0.797824 0.998648 Symptoms Heartburn (HES) T 379101 1828 377273 3.96E-05 -10.1362 120.19 1.95E-107 8.05E+97 0.93279 0.998648 Symptoms Dysphagia (HES) T 379101 5765 373336 3.22E-05 -10.3445 73.0929 1.95E-67 5.31E+57 0.887455 0.998648 Symptoms Flatulence and related conditions (HES) T 379101 1544 377557 1.79 0.583702 1.00414 0.25 12.8 0.56104 0.998648 Symptoms Faecal incontinence (HES) T 379101 1634 377467 4.65E-05 -9.97554 118.912 2.80E-106 7.72E+96 0.933144 0.998648 Symptoms Unspecified jaundice (HES) T 379101 839 378262 8.10E-05 -9.42076 119.71 1.02E-106 6.42E+97 0.937274 0.998648 Symptoms Disturbances of skin sensation (HES) T 379101 2617 376484 2.09 0.736183 0.712477 0.517 8.44 0.301476 0.998648 Symptoms Localized swelling mass and lump of skin and subcutaneous tissue (HES) T 379101 1921 377180 1.41 0.342228 1.00391 0.197 10.1 0.733184 0.998648 Symptoms Abnormal involuntary movements (HES) T 379101 819 378282 8.15E-05 -9.41477 120.877 1.04E-107 6.36E+98 0.937918 0.998648 Symptoms Other lack of coordination (HES) T 379101 322 378779 7.28E-05 -9.52823 198.917 3.47E-174 1.53E+165 0.961796 0.998648 Symptoms Signs involving the nervous and musculoskeletal systems (HES) T 379101 2611 376490 1.03 0.026084 1.00429 0.143 7.35 0.979279 0.998648 Symptoms Pain associated with micturition (HES) T 379101 1067 378034 6.38E-05 -9.65906 120.736 1.08E-107 3.78E+98 0.936236 0.998648 Symptoms Unspecified haematuria (HES) T 379101 14238 364863 0.716 -0.333723 0.508673 0.264 1.94 0.511782 0.998648 Symptoms Unspecified urinary incontinence (HES) T 379101 2162 376939 2.68 0.985309 0.713366 0.662 10.8 0.167214 0.998648 Symptoms Retention of urine (HES) T 379101 6149 372952 1.23 0.211014 0.588391 0.39 3.91 0.719872 0.998648 Symptoms Polyuria (HES) T 379101 3507 375594 0.758 -0.277089 1.00422 0.106 5.43 0.782607 0.998648 Symptoms Other symptoms and signs involving the urinary system (HES) T 379101 4602 374499 1.13 0.123256 0.714067 0.279 4.59 0.862957 0.998648 Symptoms Somnolence stupor and coma (HES) T 379101 636 378465 0.000106 -9.15591 120.177 5.33E-107 2.09E+98 0.93927 0.998648 Symptoms Symptoms cognitive functions and awareness (HES) T 379101 2889 376212 0.929 -0.073333 1.00493 0.13 6.66 0.941827 0.998648 Symptoms Dizziness and giddiness (HES) T 379101 4147 374954 1.34 0.295838 0.712836 0.332 5.44 0.678131 0.998648 Symptoms General sensations and perceptions (HES) T 379101 472 378629 5.20E-05 -9.86464 198.417 6.61E-174 4.09E+164 0.960348 0.998648 Symptoms Symptoms and signs involving emotional state (HES) T 379101 584 378517 4.40E-05 -10.0315 198.632 3.67E-174 5.28E+164 0.959722 0.998648 Symptoms Speech disturbances (HES) T 379101 1366 377735 4.89E-05 -9.92652 120.173 2.49E-107 9.60E+97 0.934168 0.998648 Symptoms Fever of unknown origin (HES) T 379101 3729 375372 1.42 0.35218 0.712542 0.352 5.75 0.621123 0.998648 Symptoms Headache (HES) T 379101 6991 372110 0.388 -0.947811 1.00357 0.0542 2.77 0.344946 0.998648 Symptoms Pain (HES) T 379101 1292 377809 5.29E-05 -9.84793 121.029 5.02E-108 5.56E+98 0.935149 0.998648 Symptoms Malaise and fatigue (HES) T 379101 2616 376485 1.06 0.062649 1.004 0.149 7.62 0.950245 0.998648 Symptoms Syncope and collapse (HES) T 379101 8267 370834 0.318 -1.14565 1.00406 0.0444 2.28 0.253861 0.998648 Symptoms Shock (HES) T 379101 252 378849 0.000103 -9.17934 194.93 1.22E-170 8.73E+161 0.962441 0.998648 Symptoms Enlarged lymph nodes (HES) T 379101 2200 376901 8.32E-05 -9.39382 73.2464 3.73E-67 1.86E+58 0.897951 0.998648 Symptoms Oedema (HES) T 379101 1490 377611 1.8 0.589838 1.00478 0.252 12.9 0.557181 0.998648 Symptoms Hyperhidrosis (HES) T 379101 544 378557 4.62E-05 -9.9826 198.325 7.03E-174 3.04E+164 0.959856 0.998648 Symptoms Symptoms and signs concerning food and fluid intake (HES) T 379101 5849 373252 0.934 -0.068165 0.712785 0.231 3.78 0.923813 0.998648 Symptoms Other general symptoms and signs (HES) T 379101 358 378743 7.45E-05 -9.50447 197.343 7.77E-173 7.15E+163 0.961587 0.998648 Symptoms Unknown and unspecified causes of morbidity (HES) T 379101 14557 364544 1.48 0.393145 0.364559 0.725 3.03 0.28085 0.998648 Symptoms Abnormality of white blood cells (HES) T 379101 236 378865 0.000109 -9.12305 199.132 3.41E-174 3.49E+165 0.963458 0.998648 Symptoms Elevated blood glucose level (HES) T 379101 625 378476 0.000114 -9.07554 119.747 1.34E-106 9.76E+97 0.939587 0.998648 Symptoms Abnormal serum enzyme levels (HES) T 379101 226 378875 0.000115 -9.06636 195.043 1.09E-170 1.22E+162 0.962925 0.998648 Symptoms Other abnormal immunological findings in serum (HES) T 379101 247 378854 0.000107 -9.1419 188.6 3.09E-165 3.71E+156 0.96134 0.998648 Symptoms Other abnormal findings of blood chemistry (HES) T 379101 5815 373286 1.81 0.592584 0.513176 0.662 4.95 0.248198 0.998648 Symptoms Isolated proteinuria (HES) T 379101 277 378824 9.17E-05 -9.29735 196.703 3.35E-172 2.51E+163 0.962301 0.998648 Symptoms Other abnormal findings in urine (HES) T 379101 297 378804 8.63E-05 -9.35712 197.875 3.17E-173 2.35E+164 0.962284 0.998648 Symptoms Abnormal findings in specimens from female genital organs (HES) T 379101 1312 377789 6.32E-08 -16.5773 3623.52 0 Inf 0.99635 0.998648 Symptoms Abnormal findings on diagnostic imaging of CNS (HES) T 379101 319 378782 7.99E-05 -9.43512 198.884 4.06E-174 1.57E+165 0.962162 0.998648 Symptoms Abnormal findings on diagnostic imaging of lung (HES) T 379101 2263 376838 8.83E-05 -9.33463 71.7457 7.50E-66 1.04E+57 0.896482 0.998648 Symptoms Abnormal findings on diagnostic imaging of other body structures (HES) T 379101 2807 376294 0.952 -0.049551 1.00418 0.133 6.81 0.960645 0.998648 Symptoms Abnormal results of function studies (HES) T 379101 3857 375244 1.44 0.362982 0.712984 0.355 5.81 0.61068 0.998648 Other Poisoning by nonopioid analgesics antipyretics and antirheumatics (HES) T 379101 1567 377534 4.64E-05 -9.97714 119.569 7.72E-107 2.79E+97 0.9335 0.998648 Other Poisoning antiepileptic hypnotic antiparkinsonism drugs (HES) T 379101 851 378250 8.19E-05 -9.40957 120.019 5.64E-107 1.19E+98 0.937509 0.998648 Other Poisoning by psychotropic drugs (HES) T 379101 1062 378039 7.03E-05 -9.56267 119.001 3.56E-106 1.39E+97 0.935953 0.998648 Other Poisoning by diuretics and other drugs (HES) T 379101 335 378766 8.26E-05 -9.40158 196.329 6.29E-172 1.09E+163 0.961806 0.998648 Other Toxic effect of alcohol (HES) T 379101 912 378189 8.25E-05 -9.40278 118.85 5.61E-106 1.21E+97 0.936941 0.998648 Medication Tetracyclines T 379101 2224 376877 1.24 0.216231 1.0039 0.174 8.88 0.829462 0.998648 Medication Beta lactam antibacterials penicillins T 379101 1102 377999 6.03E-05 -9.71545 121.151 4.52E-108 8.06E+98 0.936084 0.998648 Medication Other beta lactam antibacterials T 379101 374 378727 7.86E-05 -9.45126 192.94 4.59E-169 1.35E+160 0.960931 0.998648 Medication Sulfonamides and trimethoprim T 379101 595 378506 4.47E-05 -10.0159 197.714 2.25E-173 8.87E+163 0.959598 0.998648 Medication Aminoglycoside antibacterials T 379101 622 378479 0.000108 -9.13035 120.357 3.84E-107 3.05E+98 0.93953 0.998648 Medication Combinations of antibacterials T 379101 595 378506 0.000117 -9.05453 120.95 1.30E-107 1.05E+99 0.940325 0.998648 Medication Other antibacterials T 379101 1343 377758 5.26E-05 -9.85374 120.344 1.91E-107 1.44E+98 0.934742 0.998648 Medication Antimycotics for systemic use T 379101 389 378712 6.32E-05 -9.66922 198.809 3.72E-174 1.07E+165 0.96121 0.998648 Medication Direct acting antivirals T 379101 823 378278 3.04 1.11027 1.00468 0.424 21.7 0.269113 0.998648 Medication Antimetabolites T 379101 2405 376696 8.01E-05 -9.43263 72.995 5.87E-67 1.09E+58 0.897181 0.998648 Medication Other antineoplastic agents T 379101 1117 377984 6.68E-05 -9.61331 119.682 8.90E-107 5.02E+97 0.93598 0.998648 Medication Hormones and related agents T 379101 756 378345 8.99E-05 -9.31647 119.948 7.11E-107 1.14E+98 0.93809 0.998648 Medication Immunosuppressants T 379101 3722 375379 0.73 -0.315269 1.00365 0.102 5.22 0.753429 0.998648 Medication Antiinflammatory antirheumatic agents in combination T 379101 53678 325423 0.803 -0.219909 0.265981 0.477 1.35 0.408358 0.998648 Medication Topical products for joint and muscular pain T 379101 62133 316968 0.779 -0.25024 0.247234 0.48 1.26 0.311463 0.998648 Medication Muscle relaxants centrally acting agents T 379101 555 378546 4.51E-05 -10.0074 199.404 8.27E-175 2.45E+165 0.959974 0.998648 Medication Antigout preparations T 379101 4574 374527 0.53 -0.634893 1.00766 0.0735 3.82 0.528653 0.998648 Medication Other drugs for disorders of the musculo skeletal system T 379101 2679 376422 7.63E-05 -9.48033 71.1345 2.15E-65 2.71E+56 0.893977 0.998648 Medication Anesthetics general T 379101 221 378880 0.000111 -9.10356 199.074 3.90E-174 3.17E+165 0.963526 0.998648 Medication Opioids T 379101 102262 276839 1.1 0.098727 0.186249 0.766 1.59 0.596055 0.998648 Medication Other analgesics and antipyretics T 379101 121055 258046 1.13 0.118501 0.177269 0.795 1.59 0.503826 0.998648 Medication Antimigraine preparations T 379101 5449 373652 3.54E-05 -10.2479 71.2128 8.55E-66 1.47E+56 0.885575 0.998648 Medication Antiepileptics T 379101 6896 372205 1.18 0.166402 0.583682 0.376 3.71 0.775574 0.998648 Medication Anticholinergic agents T 379101 240 378861 0.000104 -9.16664 198.383 1.42E-173 7.69E+164 0.963145 0.998648 Medication Dopaminergic agents T 379101 1188 377913 2.32 0.839691 1.00456 0.323 16.6 0.403222 0.998648 Medication Antipsychotics T 379101 2920 376181 0.916 -0.08747 1.00362 0.128 6.55 0.930549 0.998648 Medication Anxiolytics T 379101 1664 377437 4.11E-05 -10.1 120.939 4.66E-108 3.62E+98 0.933443 0.998648 Medication Hypnotics and sedatives T 379101 3007 376094 1.85 0.614547 0.713172 0.457 7.48 0.388848 0.998648 Medication Antidepressants T 379101 29214 349887 1.04 0.04014 0.315019 0.561 1.93 0.898607 0.998648 Medication Psycholeptics and psychoanaleptics in combination T 379101 12227 366874 0.445 -0.810005 0.712283 0.11 1.8 0.255456 0.998648 Medication Anti dementia drugs T 379101 2265 376836 8.78E-05 -9.34078 72.0914 3.78E-66 2.04E+57 0.896908 0.998648 Medication Drugs used in addictive disorders T 379101 648 378453 0.000109 -9.12763 120.538 2.70E-107 4.36E+98 0.939638 0.998648 Medication Antivertigo preparations T 379101 1504 377597 4.89E-05 -9.92596 119.359 1.23E-106 1.95E+97 0.933724 0.998648 Medication Agents against amoebiasis and other protozoal diseases T 379101 660 378441 0.000105 -9.15705 120.877 1.35E-107 8.24E+98 0.939614 0.998648 Medication Antimalarials T 379101 3446 375655 5.86E-05 -9.74508 71.8869 3.77E-66 9.10E+56 0.892168 0.998648 Medication Throat preparations T 379101 49826 329275 0.821 -0.197469 0.267077 0.486 1.39 0.459682 0.998648 Medication Expectorants excl combinations with cough suppressants T 379101 1117 377984 6.91E-05 -9.58016 116.62 3.72E-104 1.28E+95 0.934529 0.998648 Medication Cough suppressants excl combinations with expectorants T 379101 2402 376699 8.12E-05 -9.41915 72.9549 6.44E-67 1.02E+58 0.897271 0.998648 Medication Antihistamines for systemic use T 379101 13321 365780 1.2 0.18222 0.417437 0.529 2.72 0.662459 0.998648 Medication Antiinfectives T 379101 4005 375096 2.06 0.722084 0.583841 0.656 6.47 0.216168 0.998648 Medication Antiinflammatory agents T 379101 18165 360936 0.884 -0.122833 0.41773 0.39 2.01 0.768721 0.998648 Medication Antiinflammatory agents and antiinfectives in combination T 379101 17347 361754 0.767 -0.265364 0.455816 0.314 1.87 0.56045 0.998648 Medication Antiglaucoma preparations and miotics T 379101 4850 374251 1.11 0.106394 0.71396 0.274 4.51 0.881538 0.998648 Medication Mydriatics and cycloplegics T 379101 287 378814 9.16E-05 -9.29771 198.607 8.02E-174 1.05E+165 0.962661 0.998648 Medication Decongestants and antiallergics T 379101 420 378681 6.08E-05 -9.70738 198.98 2.56E-174 1.44E+165 0.96109 0.998648 Medication Surgical aids T 379101 1057 378044 7.63E-05 -9.48039 116.704 3.49E-104 1.67E+95 0.935256 0.998648 Medication Chapter p Chapter X Diseases of the respiratory system BIN (HES) T 379101 9049 370052 1.57 0.448144 0.456081 0.64 3.83 0.325806 0.998648 Medication Antiinfectives T 379101 1041 378060 6.66E-05 -9.61644 120.822 9.50E-108 4.67E+98 0.936562 0.998648 Medication Corticosteroids T 379101 6270 372831 1.28 0.245137 0.58406 0.407 4.01 0.674695 0.998648 Medication Corticosteroids and antiinfectives in combination 1 T 379101 5806 373295 1.39 0.329638 0.584049 0.443 4.37 0.572481 0.998648 Medication Antiinfectives T 379101 956 378145 7.32E-05 -9.52206 120.717 1.28E-107 4.18E+98 0.937129 0.998648 Medication Corticosteroids T 379101 4111 374990 1.31 0.268545 0.712821 0.323 5.29 0.70637 0.998648 Medication Corticosteroids and antiinfectives in combination 2 T 379101 6221 372880 1.29 0.254503 0.584071 0.411 4.05 0.663026 0.998648 Medication All other therapeutic products T 379101 3557 375544 1.57 0.448109 0.713057 0.387 6.33 0.52972 0.998648 Medication Other diagnostic agents T 379101 392 378709 6.46E-05 -9.6476 198.439 7.86E-174 5.31E+164 0.961224 0.998648 Medication Magnetic resonance imaging contrast media T 379101 1522 377579 4.71E-05 -9.96416 119.298 1.33E-106 1.66E+97 0.933435 0.998648 Medication Hepatic and reticulo endothelial system T 379101 1728 377373 1.64 0.496679 1.00457 0.229 11.8 0.621011 0.998648 Medication Other diagnostic radiopharmaceuticals T 379101 3824 375277 0.728 -0.317666 1.00377 0.102 5.21 0.751644 0.998648 Cancer Lung cancer (self-reported) T 379101 205 378896 5.07E-05 -9.88868 314.636 7.62E-273 3.38E+263 0.974927 0.998648 Cancer Breast cancer (self-reported) T 379101 8389 370712 1.4 0.33797 0.517771 0.508 3.87 0.513924 0.998648 Cancer Larynx throat cancer (self-reported) T 379101 289 378812 9.14E-05 -9.30045 188.78 1.85E-165 4.50E+156 0.960707 0.998648 Cancer Colon cancer sigmoid cancer (self-reported) T 379101 1220 377881 5.77E-05 -9.76042 116.882 1.86E-104 1.79E+95 0.933449 0.998648 Cancer Rectal cancer (self-reported) T 379101 274 378827 9.20E-05 -9.29418 196.328 7.01E-172 1.21E+163 0.962242 0.998648 Cancer Kidney renal cell cancer (self-reported) T 379101 493 378608 5.02E-05 -9.89936 196.078 6.25E-172 4.03E+162 0.959734 0.998648 Cancer Bladder cancer (self-reported) T 379101 892 378209 8.12E-05 -9.41919 115.461 4.24E-103 1.55E+94 0.934982 0.998648 Cancer Ovarian cancer (self-reported) T 379101 645 378456 4.70E-08 -16.8723 5980.34 0 Inf 0.997749 0.998648 Cancer Uterine endometrial cancer (self-reported) T 379101 936 378165 3.16 1.15121 1.01048 0.436 22.9 0.254588 0.998648 Cancer Cervical cancer (self-reported) T 379101 1533 377568 5.24E-08 -16.7645 3646.6 0 Inf 0.996332 0.998648 Cancer Prostate cancer (self-reported) T 379101 2722 376379 0.867 -0.143011 1.01458 0.119 6.33 0.887905 0.998648 Cancer Testicular cancer (self-reported) T 379101 670 378431 3.62E-08 -17.1349 6008.79 0 Inf 0.997725 0.998648 Cancer Hodgkins lymphoma hodgkins disease (self-reported) T 379101 352 378749 6.80E-05 -9.59636 198.656 5.41E-174 8.55E+164 0.961472 0.998648 Cancer Non hodgkins lymphoma (self-reported) T 379101 719 378382 9.08E-05 -9.30649 120.251 3.97E-107 2.08E+98 0.938312 0.998648 Cancer Chronic lymphocytic (self-reported) T 379101 244 378857 0.000108 -9.1336 194.227 5.06E-170 2.31E+161 0.962493 0.998648 Cancer Malignant melanoma (self-reported) T 379101 2994 376107 1.78 0.576842 0.712869 0.44 7.2 0.418409 0.998648 Cancer Basal cell carcinoma (self-reported) T 379101 3552 375549 5.10E-05 -9.88293 72.5919 8.25E-67 3.16E+57 0.891708 0.998648 Cancer Squamous cell carcinoma (self-reported) T 379101 470 378631 5.41E-05 -9.82504 195.036 5.19E-171 5.64E+161 0.959823 0.998648 Cancer Thyroid cancer (self-reported) T 379101 362 378739 7.39E-05 -9.51308 195.593 2.38E-171 2.29E+162 0.961208 0.998648 Cancer Cin pre cancer cells cervix (self-reported) T 379101 1313 377788 6.48E-05 -9.64472 109.869 1.95E-98 2.16E+89 0.930049 0.998648 Neurosciences Headaches not migraine (self-reported) T 379101 3224 375877 0.815 -0.204531 1.00415 0.114 5.83 0.8386 0.998648 Cardiovascular Heart surgery (self-reported) T 379101 749 378352 8.71E-05 -9.3482 120.723 1.51E-107 5.03E+98 0.938277 0.998648 Cardiovascular Coronary angioplasty ptca stent (self-reported) T 379101 3922 375179 0.653 -0.425974 1.00755 0.0906 4.71 0.672454 0.998648 Cardiovascular Other arterial surgery revascularisation procedures (self-reported) T 379101 268 378833 9.26E-05 -9.28775 197.63 5.50E-173 1.56E+164 0.962517 0.998648 Cardiovascular Coronary artery bypass grafts cabg (self-reported) T 379101 2799 376302 0.932 -0.070927 1.01066 0.129 6.75 0.944052 0.998648 Cardiovascular Pacemaker defibrillator insertion (self-reported) T 379101 680 378421 0.000106 -9.15114 116.295 1.08E-103 1.04E+95 0.93728 0.998648 Cardiovascular Mitral valve repair replacement (self-reported) T 379101 354 378747 7.19E-05 -9.54091 192.825 5.25E-169 9.83E+159 0.960537 0.998648 Cardiovascular Fem pop bypass leg artery bypass (self-reported) T 379101 221 378880 4.49E-05 -10.0104 305.975 1.59E-265 1.27E+256 0.973901 0.998648 Cardiovascular Aortic aneurysm repair or stent (self-reported) T 379101 277 378824 9.94E-05 -9.21628 185.486 1.28E-162 7.70E+153 0.960372 0.998648 Cardiovascular Carotid artery surgery endarterectomy (self-reported) T 379101 226 378875 4.49E-05 -10.0115 309.477 1.66E-268 1.21E+259 0.974193 0.998648 Cardiovascular Cerebral artery aneurysm surgery or clipping (self-reported) T 379101 222 378879 0.000122 -9.00972 198.292 1.98E-173 7.53E+164 0.963759 0.998648 Cardiovascular Carotid artery angioplasty stent (self-reported) T 379101 333 378768 7.71E-05 -9.47027 188.435 3.08E-165 1.93E+156 0.959917 0.998648 ENT Ent surgery (self-reported) T 379101 283 378818 8.39E-05 -9.38632 199.321 1.81E-174 3.88E+165 0.96244 0.998648 ENT Ear surgery (self-reported) T 379101 6011 373090 0.436 -0.830953 1.00354 0.0609 3.11 0.407658 0.998648 ENT Nasal sinus nose surgery (self-reported) T 379101 13231 365870 0.974 -0.026298 0.456085 0.398 2.38 0.954018 0.998648 ENT Throat larynx surgery incl tracheostomy (self-reported) T 379101 2251 376850 1.18 0.164604 1.00426 0.165 8.44 0.869806 0.998648 ENT Mouth salivary gland surgery (self-reported) T 379101 2330 376771 7.94E-05 -9.44042 73.3989 2.64E-67 2.39E+58 0.89766 0.998648 Operations and Procedures Renal kidney transplant (self-reported) T 379101 252 378849 9.53E-05 -9.25888 198.356 1.36E-173 6.65E+164 0.96277 0.998648 Operations and Procedures Percutaneous open kidney stone surgery lithotripsy (self-reported) T 379101 2177 376924 8.22E-05 -9.40587 72.3246 2.24E-66 3.01E+57 0.896526 0.998648 Operations and Procedures Prostate operation (self-reported) T 379101 859 378242 3.32E-08 -17.2196 5708.95 0 Inf 0.997593 0.998648 Operations and Procedures Radical prostatectomy (self-reported) T 379101 1237 377864 1.93 0.659243 1.01356 0.265 14.1 0.51542 0.998648 Operations and Procedures Transurethral resection of prostate turp (self-reported) T 379101 1932 377169 2.67 0.980877 0.729818 0.638 11.1 0.178948 0.998648 Operations and Procedures Testicular scrotal operation (self-reported) T 379101 2430 376671 0.962 -0.038977 1.00768 0.133 6.93 0.969146 0.998648 Operations and Procedures Removal of testicle orchidectomy (self-reported) T 379101 1211 377890 5.88E-05 -9.74183 110.501 5.11E-99 6.75E+89 0.929749 0.998648 Operations and Procedures Vasectomy (self-reported) T 379101 9426 369675 1.26 0.228651 0.463981 0.506 3.12 0.622153 0.998648 Operations and Procedures Other urological surgery (self-reported) T 379101 990 378111 2.64 0.969225 1.00457 0.368 18.9 0.334637 0.998648 Metabolic Thyroid surgery (self-reported) T 379101 586 378515 4.57E-05 -9.99264 192.84 3.25E-169 6.44E+159 0.958673 0.998648 Metabolic Thyroid radioablation therapy (self-reported) T 379101 360 378741 7.85E-05 -9.45217 194.521 2.07E-170 2.98E+161 0.961244 0.998648 Metabolic Parathyroidectomy (self-reported) T 379101 531 378570 4.80E-05 -9.94363 194.571 1.15E-170 2.01E+161 0.959242 0.998648 Operations and Procedures Bone surgery joint surgery (self-reported) T 379101 3136 375965 5.52E-05 -9.80535 73.4398 1.69E-67 1.80E+58 0.893786 0.998648 Operations and Procedures Muscle soft tissue surgery (self-reported) T 379101 10926 368175 0.467 -0.76074 0.711989 0.116 1.89 0.285308 0.998648 Operations and Procedures Hip replacement revision (self-reported) T 379101 6037 373064 1.36 0.308711 0.587682 0.43 4.31 0.599373 0.998648 Operations and Procedures Knee replacement revision (self-reported) T 379101 4614 374487 0.574 -0.554633 1.00593 0.08 4.12 0.581385 0.998648 Operations and Procedures Spine or back surgery (self-reported) T 379101 4637 374464 1.11 0.10301 0.712368 0.274 4.48 0.885025 0.998648 Gynaecology and Obstetrics Gynaecological surgery (self-reported) T 379101 2168 376933 2.59 0.951003 0.718023 0.634 10.6 0.185346 0.998648 Gynaecology and Obstetrics Bilateral oophorectomy (self-reported) T 379101 15863 363238 1.13 0.125207 0.429906 0.488 2.63 0.770866 0.998648 Gynaecology and Obstetrics Unilateral oophorectomy (self-reported) T 379101 2254 376847 3.92E-05 -10.1469 110.3 5.06E-99 3.04E+89 0.926703 0.998648 Gynaecology and Obstetrics Hysterectomy (self-reported) T 379101 37549 341552 0.746 -0.293616 0.346683 0.378 1.47 0.397035 0.998648 Gynaecology and Obstetrics Endometrial ablation (self-reported) T 379101 1925 377176 4.49E-05 -10.0115 109.853 1.39E-98 1.45E+89 0.927385 0.998648 Gynaecology and Obstetrics Vaginal prolapse colposuspension (self-reported) T 379101 3479 375622 6.77E-08 -16.5088 2174.72 0 Inf 0.993943 0.998648 Gynaecology and Obstetrics Sterilisation (self-reported) T 379101 16084 363017 0.897 -0.108583 0.464712 0.361 2.23 0.815252 0.998648 Gynaecology and Obstetrics Intrauterine contraceptive device insertion removal (self-reported) T 379101 624 378477 4.91E-05 -9.92167 179.032 1.98E-157 1.22E+148 0.955805 0.998648 Gynaecology and Obstetrics Breast surgery (self-reported) T 379101 1320 377781 6.27E-05 -9.6778 112.045 2.64E-100 1.48E+91 0.931169 0.998648 Gynaecology and Obstetrics Lumpectomy (self-reported) T 379101 12746 366355 0.66 -0.415114 0.589865 0.208 2.1 0.481591 0.998648 Gynaecology and Obstetrics Mammoplasty cosmetic operation on breast (self-reported) T 379101 2699 376402 8.54E-05 -9.36827 67.3328 4.14E-62 1.76E+53 0.889344 0.998648 Cardiovascular Venous surgery procedures (self-reported) T 379101 246 378855 0.000107 -9.13857 197.792 4.65E-173 2.48E+164 0.963148 0.998648 Operations and Procedures Hernia surgery (self-reported) T 379101 2430 376671 1.01 0.006845 1.00548 0.14 7.23 0.994569 0.998648 Operations and Procedures Umbilical hernia repair (self-reported) T 379101 3357 375744 1.54 0.430596 0.712938 0.38 6.22 0.545862 0.998648 Operations and Procedures Incisional hernia repair (self-reported) T 379101 1461 377640 1.77 0.572506 1.00454 0.247 12.7 0.568732 0.998648 Operations and Procedures Bladder surgery (self-reported) T 379101 2401 376700 7.84E-05 -9.45362 72.6581 1.11E-66 5.52E+57 0.896479 0.998648 Operations and Procedures Transurethral resection bladder tumour turbt (self-reported) T 379101 458 378643 5.83E-05 -9.74963 190.128 8.42E-167 4.04E+157 0.959103 0.998648 Operations and Procedures Cystectomy (self-reported) T 379101 1986 377115 9.05E-05 -9.30984 73.4485 2.73E-67 3.00E+58 0.899136 0.998648 Operations and Procedures Urethral surgery (self-reported) T 379101 686 378415 3.72 1.31383 1.00458 0.519 26.7 0.19093 0.998648 Metabolic Thyroidectomy partial thyroidectomy (self-reported) T 379101 3577 375524 1.58 0.454571 0.715364 0.388 6.4 0.525142 0.998648 Eye Cataract extraction lens implant (self-reported) T 379101 4095 375006 1.94 0.663061 0.586453 0.615 6.13 0.258211 0.998648 Eye Glaucoma surgery trabeculectomy (self-reported) T 379101 535 378566 4.71E-05 -9.96274 194.428 1.49E-170 1.49E+161 0.959133 0.998648 Eye Retinal operation vitrectomy (self-reported) T 379101 2253 376848 1.12 0.11655 1.00472 0.157 8.05 0.907651 0.998648 Operations and Procedures Reduction or fixation of bone fracture (self-reported) T 379101 17474 361627 1.47 0.386565 0.329028 0.772 2.81 0.240047 0.998648 Operations and Procedures Other thoracic surgery (self-reported) T 379101 1195 377906 2.12 0.749804 1.00449 0.296 15.2 0.455395 0.998648 Operations and Procedures Stomach surgery (self-reported) T 379101 2197 376904 1.24 0.214709 1.00451 0.173 8.88 0.830746 0.998648 Operations and Procedures Oesophageal surgery (self-reported) T 379101 447 378654 5.28E-05 -9.84981 195.972 8.08E-172 3.44E+162 0.959914 0.998648 Operations and Procedures Pancreas surgery (self-reported) T 379101 205 378896 0.000118 -9.04867 198.56 1.13E-173 1.22E+165 0.963652 0.998648 Operations and Procedures Splenectomy (self-reported) T 379101 791 378310 8.22E-05 -9.40658 120.918 9.71E-108 6.95E+98 0.937993 0.998648 Operations and Procedures Cholecystectomy gall bladder removal (self-reported) T 379101 14872 364229 0.558 -0.582852 0.586275 0.177 1.76 0.320144 0.998648 Operations and Procedures Appendicectomy (self-reported) T 379101 45428 333673 1.35 0.297854 0.232485 0.854 2.12 0.200132 0.998648 Operations and Procedures Bowel resection (self-reported) T 379101 706 378395 9.84E-05 -9.22653 120.279 4.07E-107 2.38E+98 0.938855 0.998648 Operations and Procedures Anal surgery (self-reported) T 379101 2357 376744 2.17 0.776097 0.71285 0.537 8.79 0.276276 0.998648 Operations and Procedures Large bowel resection colostomy (self-reported) T 379101 1039 378062 2.55 0.935675 1.00476 0.356 18.3 0.351729 0.998648 Operations and Procedures Small bowel resection (self-reported) T 379101 657 378444 0.000103 -9.18546 120.853 1.38E-107 7.64E+98 0.939415 0.998648 Operations and Procedures Rectal or colon polypectomy (self-reported) T 379101 1567 377534 1.74 0.555386 1.00488 0.243 12.5 0.580475 0.998648 Operations and Procedures Colectomy hemicolectomy (self-reported) T 379101 1636 377465 1.63 0.486556 1.0045 0.227 11.7 0.62812 0.998648 Operations and Procedures Other bowel surgery (self-reported) T 379101 2282 376819 8.19E-05 -9.40967 73.1597 4.35E-67 1.54E+58 0.89766 0.998648 Operations and Procedures Brain surgery (self-reported) T 379101 1560 377541 4.15E-05 -10.0889 121.18 2.94E-108 5.87E+98 0.933649 0.998648 Operations and Procedures Intracranial haematoma drainage (self-reported) T 379101 205 378896 0.000123 -9.00456 196.703 4.49E-172 3.36E+163 0.963488 0.998648 Operations and Procedures Spinal cord surgery (self-reported) T 379101 508 378593 4.77E-05 -9.95088 199.073 1.68E-174 1.36E+165 0.960134 0.998648 Operations and Procedures Peripheral nerve surgery (self-reported) T 379101 794 378307 8.45E-05 -9.3786 121.114 6.80E-108 1.05E+99 0.938277 0.998648 Operations and Procedures Pituitary surgery (self-reported) T 379101 215 378886 0.00012 -9.0311 198.821 6.89E-174 2.08E+165 0.96377 0.998648 Operations and Procedures Skin operation or plastic surgery (self-reported) T 379101 3215 375886 0.806 -0.215827 1.00365 0.113 5.76 0.829734 0.998648 Gynaecology and Obstetrics Fertility treatment procedures (self-reported) T 379101 966 378135 8.63E-05 -9.35741 110.994 2.86E-99 2.61E+90 0.932813 0.998648 Gynaecology and Obstetrics Caesarean section caesarian section (self-reported) T 379101 19341 359760 1.06 0.059135 0.399847 0.485 2.32 0.882427 0.998648 ENT Wisdom teeth surgery (self-reported) T 379101 15032 364069 0.985 -0.014751 0.418893 0.434 2.24 0.971909 0.998648 ENT Maxillo facial surgery (self-reported) T 379101 2821 376280 6.19E-05 -9.69046 73.1792 3.16E-67 1.21E+58 0.894651 0.998648 Operations and Procedures Oesphageal fundoplication hiatus hernia surgery (self-reported) T 379101 906 378195 7.23E-05 -9.53448 120.513 1.89E-107 2.77E+98 0.936941 0.998648 Operations and Procedures Haemorroidectomy piles surgery banding of piles (self-reported) T 379101 6713 372388 0.389 -0.945444 1.00428 0.0543 2.78 0.346494 0.998648 Operations and Procedures Pilonidal sinus surgery anal (self-reported) T 379101 2174 376927 8.13E-05 -9.41697 72.3268 2.21E-66 2.99E+57 0.896408 0.998648 Operations and Procedures Abdominal pelvic adhesion surgery (self-reported) T 379101 1192 377909 5.99E-05 -9.72306 119.543 1.05E-106 3.42E+97 0.935176 0.998648 Operations and Procedures Laparotomy nos (self-reported) T 379101 2106 376995 1.3 0.265729 1.00425 0.182 9.34 0.791315 0.998648 Operations and Procedures Nephrectomy kidney removed (self-reported) T 379101 1353 377748 1.95 0.66788 1.00433 0.272 14 0.506052 0.998648 Operations and Procedures Anterior posterior repair bladder uterus (self-reported) T 379101 3518 375583 0.852 -0.159915 1.00877 0.118 6.16 0.874044 0.998648 Operations and Procedures Testicular hydrocoele surgery drainage (self-reported) T 379101 1140 377961 5.69E-08 -16.6824 3658.24 0 Inf 0.996361 0.998648 Operations and Procedures Male circumcision (self-reported) T 379101 3497 375604 4.95E-08 -16.8214 2210.62 0 Inf 0.993929 0.998648 Eye Squint correction (self-reported) T 379101 5064 374037 3.45E-05 -10.2755 73.4619 1.01E-67 1.17E+58 0.888759 0.998648 Operations and Procedures Spinal laminectomy (self-reported) T 379101 3219 375882 5.58E-05 -9.79388 73.1272 3.16E-67 9.86E+57 0.893458 0.998648 Operations and Procedures Arthroscopy nos (self-reported) T 379101 8377 370724 0.901 -0.104711 0.584073 0.287 2.83 0.857721 0.998648 Operations and Procedures Foot surgery (self-reported) T 379101 7430 371671 0.708 -0.345863 0.712392 0.175 2.86 0.627325 0.998648 Operations and Procedures Lower limb surgery (self-reported) T 379101 1770 377331 3.75E-05 -10.1916 120.176 1.90E-107 7.41E+97 0.932416 0.998648 Operations and Procedures Knee surgery not replacement (self-reported) T 379101 12555 366546 1.66 0.506956 0.365901 0.81 3.4 0.1659 0.998648 Operations and Procedures Hip surgery not replacement (self-reported) T 379101 1523 377578 1.65 0.503783 1.00405 0.231 11.8 0.615842 0.998648 Operations and Procedures Upper limb surgery (self-reported) T 379101 2145 376956 2.5 0.917679 0.713009 0.619 10.1 0.198077 0.998648 Operations and Procedures Shoulder surgery (self-reported) T 379101 5679 373422 0.896 -0.110075 0.712517 0.222 3.62 0.877225 0.998648 Operations and Procedures Elbow surgery (self-reported) T 379101 2248 376853 7.77E-05 -9.46305 73.2011 3.80E-67 1.59E+58 0.89714 0.998648 Operations and Procedures Carpal tunnel surgery (self-reported) T 379101 3953 375148 4.65E-05 -9.97634 72.506 8.89E-67 2.43E+57 0.890562 0.998648 Operations and Procedures Cruciate ligament surgery (self-reported) T 379101 1888 377213 3.48E-05 -10.2661 118.534 4.40E-106 2.75E+96 0.930982 0.998648 Operations and Procedures Bunion hallus valgus surgery (self-reported) T 379101 4996 374105 4.19E-05 -10.0797 69.5382 2.69E-64 6.52E+54 0.884749 0.998648 Operations and Procedures Removal of mole skin lesion (self-reported) T 379101 5310 373791 0.501 -0.690453 1.00355 0.0701 3.58 0.491447 0.998648 Gynaecology and Obstetrics Ovarian tubal surgery (self-reported) T 379101 1138 377963 7.06E-08 -16.4657 3646.84 0 Inf 0.996398 0.998648 Gynaecology and Obstetrics Ovarian cyst removal surgery (self-reported) T 379101 4517 374584 4.64E-08 -16.8854 2207.97 0 Inf 0.993898 0.998648 Gynaecology and Obstetrics Ectopic pregnancy surgery (self-reported) T 379101 2218 376883 3.47E-08 -17.177 3639.59 0 Inf 0.996234 0.998648 Gynaecology and Obstetrics Uterine surgery (self-reported) T 379101 1594 377507 5.03E-08 -16.8054 3645.59 0 Inf 0.996322 0.998648 Gynaecology and Obstetrics Myomectomy fibroids removed (self-reported) T 379101 2071 377030 4.08E-05 -10.1066 110.266 5.63E-99 2.96E+89 0.92697 0.998648 Gynaecology and Obstetrics Dilatation and curettage d c (self-reported) T 379101 21385 357716 0.64 -0.445905 0.464581 0.258 1.59 0.337156 0.998648 Gynaecology and Obstetrics Cervix surgery (self-reported) T 379101 1570 377531 5.69E-05 -9.77431 110.436 5.62E-99 5.76E+89 0.929474 0.998648 Gynaecology and Obstetrics Cone biopsy (self-reported) T 379101 3152 375949 7.53E-05 -9.49367 66.868 9.07E-62 6.25E+52 0.887099 0.998648 Gynaecology and Obstetrics Breast cyst abscess removal (self-reported) T 379101 3620 375481 0.822 -0.196193 1.00729 0.114 5.92 0.845571 0.998648 Gynaecology and Obstetrics Coronary angiogram (self-reported) T 379101 2517 376584 1.06 0.059205 1.00602 0.148 7.62 0.953071 0.998648 Cardiovascular Angiogram not coronary (self-reported) T 379101 345 378756 7.78E-05 -9.46082 196.9 1.93E-172 3.13E+163 0.961677 0.998648 Cardiovascular Echocardiogram transoesophageal echo (self-reported) T 379101 455 378646 5.97E-05 -9.72595 195.792 1.30E-171 2.74E+162 0.960381 0.998648 Operations and Procedures Endoscopy gastroscopy (self-reported) T 379101 7551 371550 1.86 0.622268 0.456198 0.762 4.56 0.172558 0.998648 Operations and Procedures Ercp endoscopic retrograde cholangiopancreatogram (self-reported) T 379101 341 378760 7.77E-05 -9.46241 198.15 1.67E-173 3.62E+164 0.961913 0.998648 Operations and Procedures Colonoscopy sigmoidoscopy (self-reported) T 379101 7510 371591 0.736 -0.306989 0.712576 0.182 2.97 0.666602 0.998648 Operations and Procedures Laparoscopy (self-reported) T 379101 6734 372367 0.424 -0.858386 1.00782 0.0588 3.06 0.394366 0.998648 Gynaecology and Obstetrics Hysteroscopy biopsy (self-reported) T 379101 1325 377776 6.24E-05 -9.68248 113.46 1.64E-101 2.37E+92 0.931992 0.998648 Operations and Procedures Colposcopy biopsy (self-reported) T 379101 1641 377460 5.18E-05 -9.86853 113.829 6.62E-102 4.05E+92 0.930913 0.998648 Cardiovascular Triple heart bypass (self-reported) T 379101 526 378575 5.43E-05 -9.82064 178.677 4.39E-157 6.73E+147 0.956168 0.998648 Gynaecology and Obstetrics Mastoidectomy mastoid surgery (self-reported) T 379101 700 378401 9.80E-05 -9.2306 119.432 2.13E-106 4.51E+97 0.938395 0.998648 Operations and Procedures Discectomy (self-reported) T 379101 1381 377720 1.87 0.627784 1.00403 0.262 13.4 0.531799 0.998648 Operations and Procedures Ankle surgery (self-reported) T 379101 1003 378098 6.53E-05 -9.63692 120.798 9.76E-108 4.37E+98 0.936414 0.998648 Operations and Procedures Achilles tendon repair (self-reported) T 379101 613 378488 0.000103 -9.18274 119.415 2.31E-106 4.57E+97 0.938705 0.998648 Operations and Procedures Hand finger surgery (self-reported) T 379101 1664 377437 3.84E-05 -10.1673 120.493 1.04E-107 1.41E+98 0.932754 0.998648 Operations and Procedures Dupuytren s contracture surgery (self-reported) T 379101 409 378692 6.46E-05 -9.64764 188.71 1.50E-165 2.78E+156 0.959227 0.998648 Operations and Procedures Lipoma removed excision of lipoma (self-reported) T 379101 600 378501 0.000108 -9.13253 120.756 1.75E-107 6.66E+98 0.939715 0.998648 Operations and Procedures Lymph node surgery (self-reported) T 379101 763 378338 3.49 1.25088 1.00561 0.487 25.1 0.213538 0.998648 Gynaecology and Obstetrics Salpingectomy (self-reported) T 379101 258 378843 1.16E-07 -15.972 6003.6 0 Inf 0.997877 0.998648 Gynaecology and Obstetrics Termination of pregnancy top (self-reported) T 379101 945 378156 7.66E-08 -16.3842 3624.1 0 Inf 0.996393 0.998648 Gynaecology and Obstetrics Cervical polyps removed (self-reported) T 379101 370 378731 8.37E-05 -9.3883 181.533 2.50E-159 2.80E+150 0.958754 0.998648 Gynaecology and Obstetrics Laser treatment cervix (self-reported) T 379101 611 378490 4.81E-08 -16.8506 5958.21 0 Inf 0.997743 0.998648 Gynaecology and Obstetrics Pelvic floor surgery (self-reported) T 379101 271 378830 0.000116 -9.05849 182.661 3.82E-160 3.55E+151 0.960448 0.998648 Gynaecology and Obstetrics Breast biopsy (self-reported) T 379101 375 378726 7.89E-05 -9.44742 182.043 8.69E-160 7.16E+150 0.958611 0.998648 Cardiovascular Ecg electrocardiogram (self-reported) T 379101 201 378900 0.000129 -8.95617 197.416 1.17E-172 1.43E+164 0.963815 0.998648 Operations and Procedures Cystoscopy (self-reported) T 379101 345 378756 7.08E-05 -9.55553 197.161 1.06E-172 4.75E+163 0.961345 0.998648 Cardiovascular Pacemaker insertion (self-reported) T 379101 287 378814 8.66E-05 -9.3541 190.981 2.35E-167 3.19E+158 0.960936 0.998648 Cardiovascular Cardiac ablation (self-reported) T 379101 269 378832 8.58E-05 -9.3638 197.158 1.29E-172 5.72E+163 0.96212 0.998648 ENT Tympanic membrane surgery ear drum repair (self-reported) T 379101 602 378499 0.000108 -9.13208 120.918 1.28E-107 9.15E+98 0.939799 0.998648 ENT Rhinoplasty nose surgery (self-reported) T 379101 2193 376908 7.80E-05 -9.45934 72.8527 7.56E-67 8.04E+57 0.896692 0.998648 ENT Sinus surgery (self-reported) T 379101 1301 377800 4.86E-05 -9.93289 120.767 7.71E-108 3.06E+98 0.934449 0.998648 ENT Nasal polyp surgery nasal polypectomy (self-reported) T 379101 1137 377964 5.74E-05 -9.76527 119.439 1.23E-106 2.68E+97 0.934838 0.998648 ENT Tonsillectomy tonsil surgery (self-reported) T 379101 17457 361644 0.841 -0.1734 0.418071 0.371 1.91 0.678316 0.998648 ENT Adenoid surgery adenoidectomy (self-reported) T 379101 2205 376896 7.53E-05 -9.49372 73.1843 3.81E-67 1.49E+58 0.896785 0.998648 Operations and Procedures Inguinal hernia repair (self-reported) T 379101 5531 373570 1.78 0.579192 0.514596 0.651 4.89 0.260365 0.998648 Operations and Procedures Femoral hernia repair (self-reported) T 379101 326 378775 7.15E-05 -9.54569 196.954 1.60E-172 3.20E+163 0.961344 0.998648 Operations and Procedures Urethral stricture surgery dilatation (self-reported) T 379101 205 378896 0.00012 -9.02758 198.357 1.72E-173 8.40E+164 0.963699 0.998648 Operations and Procedures Orchidopexy (self-reported) T 379101 293 378808 8.08E-08 -16.3312 5990.82 0 Inf 0.997825 0.998648 Operations and Procedures Spinal fusion (self-reported) T 379101 517 378584 4.48E-05 -10.0122 198.918 2.13E-174 9.42E+164 0.959857 0.998648 Eye Eyelid surgery (self-reported) T 379101 269 378832 8.81E-05 -9.33754 199.276 2.08E-174 3.73E+165 0.962627 0.998648 Operations and Procedures Removal of benign skin lesion (self-reported) T 379101 629 378472 0.000101 -9.2011 121.131 7.86E-108 1.30E+99 0.939451 0.998648 Operations and Procedures Removal of rodent ulcer basal cell carcinoma bcc (self-reported) T 379101 957 378144 2.77 1.01816 1.0051 0.386 19.8 0.311066 0.998648 Operations and Procedures Skin graft (self-reported) T 379101 649 378452 9.80E-05 -9.23031 120.694 1.80E-107 5.35E+98 0.93904 0.998648 Operations and Procedures Mri magnetic resonance imaging (self-reported) T 379101 522 378579 4.50E-05 -10.0083 199.192 1.25E-174 1.62E+165 0.959928 0.998648 Operations and Procedures Ct scan (self-reported) T 379101 307 378794 7.96E-05 -9.43912 198.573 7.45E-174 8.50E+164 0.962087 0.998648 Operations and Procedures Bone scan (self-reported) T 379101 213 378888 5.02E-05 -9.8986 314.914 4.37E-273 5.77E+263 0.974924 0.998648 Operations and Procedures Ultrasound scan (self-reported) T 379101 230 378871 0.000107 -9.13865 199.172 3.11E-174 3.71E+165 0.963403 0.998648 Operations and Procedures Barium meal barium swallow (self-reported) T 379101 221 378880 0.000107 -9.13992 198.145 2.32E-173 4.95E+164 0.963209 0.998648 Operations and Procedures Biopsy (self-reported) T 379101 275 378826 8.62E-05 -9.35887 199.236 2.20E-174 3.38E+165 0.962534 0.998648 Operations and Procedures Prostate biopsy (self-reported) T 379101 258 378843 3.86E-08 -17.071 9507.9 0 Inf 0.998567 0.998648 Family history Alzheimer s disease dementia (family history - father) T 343592 15771 327821 0.479 -0.735175 0.584235 0.153 1.51 0.208263 0.998648 Family history Parkinson s disease (family history - father) T 338729 8344 330385 0.298 -1.20943 0.995627 0.0424 2.1 0.224466 0.998648 Family history Severe depression (family history - father) T 338729 12638 326091 0.792 -0.233072 0.508233 0.293 2.14 0.646526 0.998648 Family history Prostate cancer (family history - father) T 338729 25442 313287 0.869 -0.140782 0.345514 0.441 1.71 0.683672 0.998648 Family history Stroke (family history - father) T 343592 51292 292300 1.13 0.121414 0.233603 0.714 1.78 0.603242 0.998648 Family history Lung cancer (family history - father) T 338729 30466 308263 0.959 -0.042365 0.315719 0.516 1.78 0.893256 0.998648 Family history Bowel cancer (family history - father) T 338729 19587 319142 1.05 0.046285 0.364974 0.512 2.14 0.899085 0.998648 Family history Chronic bronchitis emphysema (family history - father) T 343592 37574 306018 1.17 0.158932 0.26793 0.693 1.98 0.553058 0.998648 Family history Diabetes (family history - father) T 343592 31628 311964 0.774 -0.256252 0.329701 0.406 1.48 0.437027 0.998648 Family history Alzheimer s disease dementia (family history - mother) T 357529 29815 327714 0.946 -0.055457 0.316575 0.509 1.76 0.86094 0.998648 Family history Parkinson s disease (family history - mother) T 354181 5725 348456 1.34 0.294448 0.584439 0.427 4.22 0.614392 0.998648 Family history Severe depression (family history - mother) T 354181 23297 330884 0.879 -0.128495 0.36482 0.43 1.8 0.724678 0.998648 Family history Heart disease (family history - mother) T 357529 69487 288042 0.807 -0.213964 0.233704 0.511 1.28 0.359912 0.998648 Family history Stroke (family history - mother) T 357529 49690 307839 1.06 0.057826 0.24353 0.657 1.71 0.812308 0.998648 Family history Lung cancer (family history - mother) T 354181 14282 339899 0.938 -0.064246 0.456116 0.384 2.29 0.887985 0.998648 Family history Breast cancer (family history - mother) T 350614 12118 338496 0.628 -0.464939 0.584019 0.2 1.97 0.425973 0.998648 Family history High blood pressure (family history - mother) T 357529 106967 250562 0.841 -0.173638 0.1932 0.576 1.23 0.368787 0.998648 Family history Diabetes (family history - mother) T 357529 32382 325147 0.851 -0.161761 0.314356 0.459 1.58 0.606847 0.998648 Family history Alzheimer s disease dementia (family history - sibling) T 301029 1677 299352 3.48E-05 -10.2664 123.064 6.13E-110 1.97E+100 0.933515 0.998648 Family history Parkinson s disease (family history - sibling) T 301236 1576 299660 3.38E-05 -10.2946 124.634 2.74E-111 4.17E+101 0.934171 0.998648 Family history Severe depression (family history - sibling) T 301236 21287 279949 0.799 -0.224484 0.389536 0.372 1.71 0.564421 0.998648 Family history Prostate cancer (family history - sibling) T 301236 4736 296500 1.98 0.680626 0.513306 0.722 5.4 0.184851 0.998648 Family history Stroke (family history - sibling) T 301029 9517 291512 0.77 -0.261321 0.587049 0.244 2.43 0.656216 0.998648 Family history Lung cancer (family history - sibling) T 301236 6394 294842 0.748 -0.290672 0.716304 0.184 3.04 0.684894 0.998648 Family history Bowel cancer (family history - sibling) T 301236 7001 294235 1.02 0.017837 0.587534 0.322 3.22 0.975781 0.998648 Family history Breast cancer (family history - sibling) T 298653 4866 293787 3.06E-05 -10.3935 76.8364 1.21E-70 7.77E+60 0.8924 0.998648 Family history High blood pressure (family history - sibling) T 301029 61052 239977 0.996 -0.003754 0.225962 0.64 1.55 0.986746 0.998648 Family history Diabetes (family history - sibling) T 301029 24485 276544 0.994 -0.006021 0.331201 0.519 1.9 0.985496 0.998648 Mental health Single episode of probable major depression T 54642 7501 47141 1.21 0.189594 0.450399 0.5 2.92 0.673793 0.998648 Mental health Probable recurrent major depression severe 2 T 54213 7072 47141 0.436 -0.83099 0.729194 0.104 1.82 0.254453 0.998648 Mental health Bipolar I Disorder T 91515 595 90920 2.68E-05 -10.5259 208.411 1.06E-182 6.79E+172 0.95972 0.998648 Mental health Bipolar II Disorder T 91515 531 90984 2.91E-05 -10.4442 208.973 3.83E-183 2.22E+173 0.960139 0.998648 Mental health Probable Recurrent major depression severe 1 T 91515 6715 84800 0.54 -0.617052 0.72308 0.131 2.23 0.393456 0.998648 Mental health Probable Recurrent major depression moderate T 91515 11528 79987 0.445 -0.809761 0.599102 0.138 1.44 0.176495 0.998648 Mental health Risk taking T 365648 96122 269526 1.02 0.023915 0.193605 0.701 1.5 0.901691 0.998648 Mental health Seen doctor GP for nerves anxiety tension or depression T 376439 129804 246635 0.889 -0.117802 0.183884 0.62 1.27 0.521763 0.998648 Mental health Seen a psychiatrist for nerves anxiety tension or depression T 377320 43632 333688 0.837 -0.177722 0.281533 0.482 1.45 0.527867 0.998648 Eye Wears glasses or contact lenses T 378528 337207 41321 0.752 -0.285564 0.267739 0.445 1.27 0.286162 0.998648 Eye Other eye problems T 377958 54312 323646 1.02 0.023358 0.236947 0.643 1.63 0.921473 0.998648 ENT Hearing difficulty problems T 363644 94775 268869 0.805 -0.216853 0.21039 0.533 1.22 0.302671 0.998648 ENT Hearing difficulty problems with background noise T 371480 140624 230856 0.825 -0.192618 0.181576 0.578 1.18 0.288777 0.998648 Other Hair balding pattern T 173279 117813 55466 0.795 -0.228994 0.24481 0.492 1.29 0.349584 0.998648 Other Pattern 1 f T 173279 55466 117813 1.26 0.228994 0.24481 0.778 2.03 0.349584 0.998648 Other Pattern 2 f T 173279 39959 133320 0.726 -0.320811 0.307894 0.397 1.33 0.297434 0.998648 Other Pattern 3 f T 173279 46281 126998 1.15 0.139075 0.261663 0.688 1.92 0.59507 0.998648 Other Pattern 4 f T 173279 31573 141706 0.821 -0.197367 0.328705 0.431 1.56 0.548214 0.998648 Gynaecology and Obstetrics Ever had stillbirth spontaneous miscarriage or termination T 201246 64150 137096 1.36 0.310036 0.243563 0.846 2.2 0.203045 0.998648 Gynaecology and Obstetrics Bilateral oophorectomy both ovaries removed T 201585 16364 185221 1.09 0.089657 0.430442 0.47 2.54 0.835002 0.998648 Neurosciences General pain for 3 months vs no pain T 377203 4819 372384 0.572 -0.558517 1.00374 0.08 4.09 0.577911 0.998648 ENT Hearing aid user T 230555 11351 219204 0.698 -0.359241 0.592056 0.219 2.23 0.544005 0.998648 Neurosciences Neck shoulder pain for 3 months vs no pain T 344932 58990 285942 0.889 -0.117952 0.243007 0.552 1.43 0.627403 0.998648 Gynaecology and Obstetrics Ever had hysterectomy womb removed T 180543 14618 165925 0.58 -0.543986 0.601126 0.179 1.89 0.365494 0.998648 Neurosciences Headaches for 3 months vs no pain T 330531 33891 296640 1.21 0.189505 0.279521 0.699 2.09 0.497795 0.998648 Cancer Mal neo oesophagus (cancer register) T 379101 516 378585 5.17E-05 -9.86928 190.314 5.19E-167 5.16E+157 0.958642 0.998648 Cancer Mal neo stomach (cancer register) T 379101 377 378724 7.04E-05 -9.56098 191.509 6.79E-168 7.30E+158 0.960183 0.998648 Cancer Mal neo colon (cancer register) T 379101 2575 376526 1.03 0.027575 1.00544 0.143 7.38 0.97812 0.998648 Cancer Mal neo rectosigmoid (cancer register) T 379101 343 378758 7.34E-05 -9.51903 193.022 3.65E-169 1.48E+160 0.960668 0.998648 Cancer Mal neo rectum (cancer register) T 379101 1203 377898 5.76E-05 -9.76263 117.997 2.08E-105 1.59E+96 0.934061 0.998648 Cancer Mal neo liver (cancer register) T 379101 217 378884 0.000122 -9.01114 192.765 1.00E-168 1.48E+160 0.962715 0.998648 Cancer Mal neo pancreas (cancer register) T 379101 463 378638 5.48E-05 -9.81228 193.782 6.14E-170 4.89E+160 0.959616 0.998648 Cancer Mal neo larynx (cancer register) T 379101 224 378877 4.66E-05 -9.97401 302.88 7.11E-263 3.05E+253 0.97373 0.998648 Cancer Mal neo bronchus and lung (cancer register) T 379101 1742 377359 4.41E-05 -10.03 116.251 4.89E-104 3.97E+94 0.931244 0.998648 Cancer Mal melanoma of skin (cancer register) T 379101 2611 376490 2 0.695261 0.712721 0.496 8.1 0.329311 0.998648 Cancer Mal neo other connect soft tissue (cancer register) T 379101 247 378854 9.67E-05 -9.24408 198.351 1.40E-173 6.69E+164 0.962828 0.998648 Cancer Mal neo breast (cancer register) T 379101 10158 368943 1.47 0.383264 0.465272 0.589 3.65 0.410086 0.998648 Cancer Mal neo cervix uteri (cancer register) T 379101 384 378717 7.74E-08 -16.3747 6004.91 0 Inf 0.997824 0.998648 Cancer Mal neo corpus uteri (cancer register) T 379101 1276 377825 2.33 0.847916 1.01044 0.322 16.9 0.401382 0.998648 Cancer Mal neo ovary (cancer register) T 379101 893 378208 9.29E-08 -16.192 3630.88 0 Inf 0.996442 0.998648 Cancer Mal neo prostate (cancer register) T 379101 6546 372555 1.11 0.105743 0.598312 0.344 3.59 0.859716 0.998648 Cancer Mal neo testis (cancer register) T 379101 451 378650 5.50E-08 -16.7155 5965.21 0 Inf 0.997764 0.998648 Cancer Mal neo kidney (cancer register) T 379101 918 378183 2.76 1.01528 1.00567 0.384 19.8 0.312709 0.998648 Cancer Mal neo bladder (cancer register) T 379101 919 378182 7.69E-05 -9.47255 113.278 2.90E-101 2.04E+92 0.933357 0.998648 Cancer Mal neo brain (cancer register) T 379101 407 378694 5.86E-05 -9.74515 198.644 4.77E-174 7.19E+164 0.960873 0.998648 Cancer Mal neo thyroid gland (cancer register) T 379101 431 378670 6.19E-05 -9.68988 197.727 3.04E-173 1.26E+164 0.960914 0.998648 Cancer Hodgkin s disease (cancer register) T 379101 245 378856 9.71E-05 -9.23994 198.515 1.02E-173 9.26E+164 0.962876 0.998648 Cancer Diffuse non Hodgkin s lymphoma (cancer register) T 379101 730 378371 9.24E-05 -9.28934 118.886 5.86E-106 1.46E+97 0.937719 0.998648 Cancer Other types of non Hodgkin s lymphoma (cancer register) T 379101 408 378693 5.98E-05 -9.72399 197.593 3.82E-173 9.36E+163 0.96075 0.998648 Cancer Multiple myeloma (cancer register) T 379101 459 378642 5.66E-05 -9.77867 195.128 4.54E-171 7.07E+161 0.960031 0.998648 Cancer Lymphoid leukaemia (cancer register) T 379101 519 378582 4.94E-05 -9.91615 194.51 1.33E-170 1.84E+161 0.959341 0.998648 Cancer Myeloid leukaemia (cancer register) T 379101 321 378780 7.73E-05 -9.46842 197.528 5.61E-173 1.06E+164 0.961768 0.998648 Cancer Carc in situ of other digestive organs (cancer register) T 379101 262 378839 9.50E-05 -9.26151 195.253 5.96E-171 1.52E+162 0.962168 0.998648 Cancer Melanoma in situ (cancer register) T 379101 1026 378075 2.54 0.933049 1.00458 0.355 18.2 0.352994 0.998648 Cancer Carc in situ of skin (cancer register) T 379101 1157 377944 6.84E-05 -9.58975 115.551 2.99E-103 1.56E+94 0.933859 0.998648 Cancer Carc in situ of breast (cancer register) T 379101 1900 377201 4.57E-05 -9.99368 109.987 1.09E-98 1.92E+89 0.927602 0.998648 Cancer Carc in situ of cervix (cancer register) T 379101 2991 376110 7.97E-08 -16.3448 2184.63 0 Inf 0.99403 0.998648 Cancer Car in situ other genital (cancer register) T 379101 466 378635 5.28E-05 -9.8487 194.977 5.69E-171 4.90E+161 0.959714 0.998648 Cancer Carc in situ of other sites (cancer register) T 379101 561 378540 4.93E-05 -9.91846 188.321 2.46E-165 9.88E+155 0.957996 0.998648 Cancer Benign neoplasm of meninges (cancer register) T 379101 350 378751 7.50E-05 -9.49746 195.508 2.85E-171 1.97E+162 0.961255 0.998648 Cancer Neo of oral cavity and digestive (cancer register) T 379101 341 378760 7.20E-05 -9.53877 196.017 1.01E-171 5.13E+162 0.961188 0.998648 Cancer Neo of urinary organs (cancer register) T 379101 723 378378 9.54E-05 -9.25725 116.187 1.20E-103 7.59E+94 0.936495 0.998648 Cancer Neo of lymphoid haematopoietic (cancer register) T 379101 292 378809 9.04E-05 -9.31178 195.435 3.97E-171 2.06E+162 0.961998 0.998648 Cancer Neo of other sites (cancer register) T 379101 206 378895 0.000109 -9.12172 198.301 1.74E-173 6.85E+164 0.963311 0.998648 Summary Mal neo of lip oral cavity and pharynx (cancer register) T 379101 799 378302 8.38E-05 -9.38767 119.648 1.19E-106 5.88E+97 0.937462 0.998648 Summary Mal neo of digestive organs (cancer register) T 379101 5957 373144 0.438 -0.825382 1.00505 0.0611 3.14 0.411511 0.998648 Summary Mal neo of respiratory and intrathoracic organs (cancer register) T 379101 2026 377075 3.73E-05 -10.1965 116.301 3.75E-104 3.71E+94 0.930136 0.998648 Summary Melanoma and other mal neo of skin (cancer register) T 379101 2611 376490 2 0.695261 0.712721 0.496 8.1 0.329311 0.998648 Summary Mal neo of mesothelial and soft tissue (cancer register) T 379101 538 378563 4.70E-05 -9.96617 196.294 3.83E-172 5.76E+162 0.959507 0.998648 Summary Mal neoplasm of breast (cancer register) T 379101 10158 368943 1.47 0.383264 0.465272 0.589 3.65 0.410086 0.998648 Summary Mal neo of female genital organs (cancer register) T 379101 2734 376367 1.08 0.077513 1.00833 0.15 7.8 0.938725 0.998648 Summary Mal neo of male genital organs (cancer register) T 379101 7046 372055 1.03 0.025753 0.596185 0.319 3.3 0.965545 0.998648 Summary Mal neo of urinary tract (cancer register) T 379101 1919 377182 1.31 0.271644 1.00668 0.182 9.44 0.787282 0.998648 Summary Mal neo of thyroid and other endocrine glands (cancer register) T 379101 468 378633 5.61E-05 -9.78811 198.078 1.39E-173 2.27E+164 0.960588 0.998648 Summary Mal neo of ill secondary unspecified (cancer register) T 379101 433 378668 5.90E-05 -9.73818 197.188 8.34E-173 4.17E+163 0.960612 0.998648 Summary Mal neo lymphoid haematopoietic (cancer register) T 379101 3145 375956 0.83 -0.186345 1.00458 0.116 5.95 0.852841 0.998648 Summary In situ neo (cancer register) T 379101 8358 370743 0.332 -1.10248 1.00431 0.0464 2.38 0.272313 0.998648 Summary Benign neo (cancer register) T 379101 784 378317 8.49E-05 -9.37375 120.695 1.55E-107 4.64E+98 0.938094 0.998648 Summary Neo of uncertain or unknown behaviour (cancer register) T 379101 2117 376984 1.21 0.192562 1.00474 0.169 8.69 0.848015 0.998648 Summary Neoplasms BIN (cancer register) T 379101 45225 333876 0.814 -0.205852 0.28377 0.467 1.42 0.468195 0.998648 Neurosciences Facial pains for 3 months vs no pain T 368676 3287 365389 5.70E-05 -9.7728 73.2772 2.40E-67 1.35E+58 0.893903 0.998648 Operations and Procedures Excision of lesion of tissue of brain T 379101 434 378667 5.50E-05 -9.80741 199.425 9.70E-175 3.12E+165 0.960777 0.998648 Operations and Procedures Other operations on ventricle of brain T 379101 227 378874 0.000109 -9.12603 199.041 4.07E-174 2.91E+165 0.96343 0.998648 Operations and Procedures Extirpation of lesion of meninges of brain T 379101 289 378812 9.06E-05 -9.30919 197.083 1.57E-172 5.22E+163 0.962326 0.998648 Operations and Procedures Drainage of subdural space T 379101 236 378865 0.000108 -9.136 191.71 7.01E-168 1.66E+159 0.961991 0.998648 Operations and Procedures Other operations on spinal cord T 379101 218 378883 0.000115 -9.06845 198.811 6.77E-174 1.96E+165 0.963618 0.998648 Operations and Procedures Therapeutic epidural injection T 379101 4695 374406 3.89E-05 -10.1543 73.2697 1.67E-67 9.09E+57 0.889776 0.998648 Operations and Procedures Therapeutic spinal puncture T 379101 253 378848 0.000101 -9.20442 199.093 3.40E-174 2.98E+165 0.963126 0.998648 Operations and Procedures Diagnostic spinal puncture T 379101 4837 374264 1.12 0.110771 0.712366 0.277 4.51 0.876429 0.998648 Operations and Procedures Operations on spinal nerve root T 379101 2302 376799 1.16 0.15257 1.00393 0.163 8.33 0.879208 0.998648 Operations and Procedures Destruction of peripheral nerve T 379101 243 378858 9.70E-05 -9.24038 198.249 1.71E-173 5.49E+164 0.962824 0.998648 Operations and Procedures Extirpation of lesion of peripheral nerve T 379101 1390 377711 5.22E-05 -9.86011 118.991 2.70E-106 1.01E+97 0.93396 0.998648 Operations and Procedures Microsurgical repair of peripheral nerve T 379101 222 378879 0.000101 -9.20526 196.001 1.45E-171 6.94E+162 0.962541 0.998648 Operations and Procedures Other repair of peripheral nerve T 379101 526 378575 4.87E-05 -9.93076 197.763 2.23E-173 1.06E+164 0.959951 0.998648 Operations and Procedures Release of entrapment of peripheral nerve at wrist T 379101 8745 370356 0.304 -1.19069 1.00399 0.0425 2.18 0.23564 0.998648 Operations and Procedures Release of entrapment of peripheral nerve at other site T 379101 778 378323 8.37E-05 -9.38806 120.898 1.03E-107 6.81E+98 0.938104 0.998648 Operations and Procedures Other release of peripheral nerve T 379101 324 378777 7.56E-05 -9.48953 198.517 7.90E-174 7.24E+164 0.961874 0.998648 Operations and Procedures Neurostimulation of peripheral nerve T 379101 545 378556 4.77E-05 -9.95 197.293 5.49E-173 4.15E+163 0.959778 0.998648 Operations and Procedures Neurophysiological operations T 379101 2161 376940 8.73E-05 -9.34619 72.9227 7.38E-67 1.03E+58 0.898018 0.998648 Operations and Procedures Excision of thyroid gland T 379101 1898 377203 1.5 0.406797 1.00503 0.209 10.8 0.685653 0.998648 Operations and Procedures Excision of parathyroid gland T 379101 695 378406 0.000104 -9.17512 117.958 4.05E-105 2.65E+96 0.938 0.998648 Operations and Procedures Total excision of breast T 379101 4061 375040 2.19 0.782537 0.589738 0.688 6.95 0.184534 0.998648 Operations and Procedures Other excision of breast T 379101 9523 369578 1.24 0.212441 0.515105 0.451 3.39 0.680029 0.998648 Operations and Procedures Reconstruction of breast T 379101 1391 377710 5.71E-08 -16.6781 3648.16 0 Inf 0.996352 0.998648 Operations and Procedures Prosthesis for breast T 379101 1450 377651 5.88E-05 -9.74162 110.435 5.82E-99 5.94E+89 0.929709 0.998648 Operations and Procedures Other plastic operations on breast T 379101 1690 377411 5.43E-05 -9.82109 110.347 6.39E-99 4.61E+89 0.929081 0.998648 Operations and Procedures Biopsy of breast T 379101 1566 377535 5.76E-05 -9.76246 110.694 3.43E-99 9.66E+89 0.929723 0.998648 Operations and Procedures Incision of breast T 379101 615 378486 5.03E-05 -9.8973 186.17 1.70E-163 1.49E+154 0.957602 0.998648 Operations and Procedures Operations on duct of breast T 379101 761 378340 3.87 1.35212 1.00815 0.536 27.9 0.179858 0.998648 Operations and Procedures Operations on nipple T 379101 610 378491 5.15E-05 -9.87322 187.963 5.19E-165 5.12E+155 0.958108 0.998648 Operations and Procedures Reconstruction of nipple and areola T 379101 637 378464 5.00E-05 -9.90291 181.816 8.60E-160 2.91E+150 0.956563 0.998648 Operations and Procedures Other operations on breast T 379101 910 378191 9.71E-05 -9.24024 110.682 5.92E-99 1.59E+90 0.933466 0.998648 Operations and Procedures Reconstruction of breast using abdominal flap T 379101 275 378826 1.08E-07 -16.0414 5978.55 0 Inf 0.997859 0.998648 Operations and Procedures Operations on eyebrow T 379101 613 378488 0.000112 -9.09931 120.216 5.23E-107 2.39E+98 0.939665 0.998648 Operations and Procedures Extirpation of lesion of eyelid T 379101 5517 373584 0.988 -0.012001 0.712516 0.245 3.99 0.986562 0.998648 Operations and Procedures Excision of redundant skin of eyelid T 379101 1118 377983 6.49E-05 -9.64338 118.739 5.49E-106 7.67E+96 0.935271 0.998648 Operations and Procedures Reconstruction of eyelid T 379101 382 378719 6.77E-05 -9.60077 196.541 3.40E-172 1.35E+163 0.96104 0.998648 Operations and Procedures Correction of deformity of eyelid T 379101 816 378285 3.21 1.16599 1.00746 0.445 23.1 0.247126 0.998648 Operations and Procedures Correction of ptosis of eyelid T 379101 747 378354 3.53 1.26131 1.00588 0.492 25.4 0.209864 0.998648 Operations and Procedures Other operations on eyelid T 379101 931 378170 2.99 1.09569 1.00481 0.417 21.4 0.27552 0.998648 Operations and Procedures Connection between lacrimal apparatus and nose T 379101 711 378390 0.000105 -9.15894 118.418 1.67E-105 6.63E+96 0.93835 0.998648 Operations and Procedures Operations on nasolacrimal duct T 379101 416 378685 6.69E-05 -9.61261 196.252 5.92E-172 7.56E+162 0.960935 0.998648 Operations and Procedures Other operations on lacrimal apparatus T 379101 939 378162 7.76E-05 -9.4637 118.891 4.87E-106 1.24E+97 0.936556 0.998648 Operations and Procedures Combined operations on muscles of eye T 379101 370 378731 6.71E-05 -9.60954 199.584 8.66E-175 5.20E+165 0.961598 0.998648 Operations and Procedures Other adjustment to muscle of eye T 379101 211 378890 0.000117 -9.05179 199.101 3.90E-174 3.52E+165 0.963738 0.998648 Operations and Procedures Extirpation of lesion of conjunctiva T 379101 351 378750 7.18E-05 -9.54164 198.577 6.67E-174 7.73E+164 0.961676 0.998648 Operations and Procedures Closure of cornea T 379101 204 378897 0.000122 -9.01187 198.676 9.33E-174 1.59E+165 0.963821 0.998648 Operations and Procedures Buckling operations for attachment of retina T 379101 659 378442 3.83 1.34392 1.0053 0.534 27.5 0.181277 0.998648 Operations and Procedures Filtering operations on iris T 379101 833 378268 3.19 1.15936 1.006 0.444 22.9 0.249134 0.998648 Operations and Procedures Other operations on trabecular meshwork of eye T 379101 236 378865 0.000113 -9.08543 195.404 5.28E-171 2.43E+162 0.962915 0.998648 Operations and Procedures Incision of iris T 379101 599 378502 4.24E-05 -10.0677 195.431 1.88E-171 9.59E+161 0.958915 0.998648 Operations and Procedures Other operations on anterior chamber of eye T 379101 405 378696 6.25E-05 -9.67956 195.602 1.98E-171 1.98E+162 0.960532 0.998648 Operations and Procedures Extracapsular extraction of lens T 379101 17912 361189 1.25 0.222891 0.372165 0.603 2.59 0.549237 0.998648 Operations and Procedures Prosthesis of lens T 379101 17908 361193 1.25 0.222107 0.372086 0.602 2.59 0.550559 0.998648 Operations and Procedures Operations on vitreous body T 379101 3853 375248 4.73E-05 -9.95839 72.0345 2.28E-66 9.82E+56 0.890047 0.998648 Operations and Procedures Operations on retinal membrane T 379101 983 378118 7.23E-05 -9.53462 116.981 1.92E-104 2.73E+95 0.93504 0.998648 Operations and Procedures Photocoagulation of retina for detachment T 379101 972 378129 2.66 0.980152 1.00494 0.372 19.1 0.329396 0.998648 Operations and Procedures Destruction of lesion of retina T 379101 2270 376831 1.13 0.122189 1.00473 0.158 8.1 0.903205 0.998648 Operations and Procedures Fixation of retina T 379101 1034 378067 5.84E-05 -9.74876 119.693 7.61E-107 4.48E+97 0.935086 0.998648 Operations and Procedures Other operations on eye T 379101 768 378333 8.96E-05 -9.31995 119.759 1.03E-106 7.82E+97 0.937969 0.998648 Operations and Procedures Local anaesthetics for ophthalmology procedures T 379101 5563 373538 1.4 0.337494 0.587952 0.443 4.44 0.565957 0.998648 Operations and Procedures Extirpation of lesion of external ear T 379101 1684 377417 3.99E-05 -10.1288 117.198 6.92E-105 2.30E+95 0.931128 0.998648 Operations and Procedures Plastic operations on external ear T 379101 299 378802 8.49E-05 -9.37404 194.387 2.91E-170 2.48E+161 0.961538 0.998648 Operations and Procedures Other operations on external ear T 379101 435 378666 5.78E-05 -9.75843 196.885 1.48E-172 2.26E+163 0.96047 0.998648 Operations and Procedures Clearance of external auditory canal T 379101 325 378776 7.54E-05 -9.49284 198.624 6.38E-174 8.90E+164 0.961881 0.998648 Operations and Procedures Exenteration of mastoid air cells T 379101 445 378656 5.74E-05 -9.76527 198.497 6.24E-174 5.29E+164 0.960763 0.998648 Operations and Procedures Other operations on mastoid T 379101 342 378759 7.46E-05 -9.50394 198.208 1.43E-173 3.90E+164 0.961757 0.998648 Operations and Procedures Repair of eardrum T 379101 1054 378047 6.66E-05 -9.6174 120.787 1.02E-107 4.36E+98 0.936537 0.998648 Operations and Procedures Drainage of middle ear T 379101 1751 377350 1.56 0.445882 1.00396 0.218 11.2 0.656953 0.998648 Operations and Procedures Reconstruction of ossicular chain T 379101 220 378881 0.000117 -9.05366 198.896 5.81E-174 2.35E+165 0.963693 0.998648 Operations and Procedures Other operations on ossicle of ear T 379101 327 378774 7.52E-05 -9.49524 199.486 1.18E-174 4.81E+165 0.962036 0.998648 Operations and Procedures Other operations on middle ear T 379101 277 378824 8.84E-05 -9.33338 199.674 9.56E-175 8.18E+165 0.962718 0.998648 Operations and Procedures Other operations on ear T 379101 414 378687 5.92E-05 -9.73413 199.012 2.34E-174 1.50E+165 0.960989 0.998648 Operations and Procedures Plastic operations on nose T 379101 781 378320 9.07E-05 -9.30768 120.374 3.11E-107 2.64E+98 0.938366 0.998648 Operations and Procedures Operations on septum of nose T 379101 4412 374689 1.83 0.606579 0.584769 0.583 5.77 0.299597 0.998648 Operations and Procedures Surgical arrest of bleeding from internal nose T 379101 782 378319 3.33 1.20176 1.00567 0.463 23.9 0.232093 0.998648 Operations and Procedures Packing of cavity of nose T 379101 1016 378085 2.64 0.971515 1.00539 0.368 19 0.333892 0.998648 Operations and Procedures Operations on external nose T 379101 3310 375791 0.813 -0.20742 1.00437 0.113 5.82 0.836386 0.998648 Operations and Procedures Other operations on nose T 379101 294 378807 8.64E-05 -9.35687 198.162 1.81E-173 4.12E+164 0.962339 0.998648 Operations and Procedures Operations on frontal sinus T 379101 1944 377157 1.38 0.325293 1.00407 0.193 9.91 0.745958 0.998648 Operations and Procedures Operations on unspecified nasal sinus T 379101 717 378384 9.82E-05 -9.22802 120.576 2.27E-107 4.25E+98 0.938995 0.998648 Operations and Procedures Diagnostic endoscopic examination of pharynx T 379101 3123 375978 1.72 0.543014 0.712866 0.426 6.96 0.446219 0.998648 Operations and Procedures Other operations on pharynx T 379101 503 378598 4.90E-05 -9.92378 199.194 1.36E-174 1.77E+165 0.960266 0.998648 Operations and Procedures Microtherapeutic endoscopic operations on larynx T 379101 579 378522 4.57E-05 -9.9932 197.503 3.48E-173 6.00E+163 0.959646 0.998648 Operations and Procedures Other therapeutic endoscopic operations on larynx T 379101 206 378895 0.000123 -9.00403 197.438 1.06E-172 1.42E+164 0.963626 0.998648 Operations and Procedures Exteriorisation of trachea T 379101 817 378284 8.41E-05 -9.38403 118.778 6.59E-106 1.07E+97 0.937029 0.998648 Operations and Procedures Operations on lower respiratory tract T 379101 209 378892 0.000132 -8.93309 193.588 2.16E-169 8.05E+160 0.963195 0.998648 Operations and Procedures Diagnostic endos exam of lwr resp trct rigid brnchscpe T 379101 452 378649 5.96E-05 -9.72732 195.619 1.82E-171 1.95E+162 0.960341 0.998648 Operations and Procedures Excision of lung T 379101 810 378291 9.09E-05 -9.30601 118.17 2.34E-105 3.52E+96 0.93723 0.998648 Operations and Procedures Other operations on lung T 379101 801 378300 8.96E-05 -9.32049 118.44 1.36E-105 5.89E+96 0.937276 0.998648 Operations and Procedures Diagnostic endoscopic examination of mediastinum T 379101 587 378514 4.63E-05 -9.97982 195.222 3.09E-171 6.95E+161 0.95923 0.998648 Operations and Procedures Extirpation of lesion of lip T 379101 1563 377538 1.83 0.602413 1.00421 0.255 13.1 0.548583 0.998648 Operations and Procedures Other repair of lip T 379101 211 378890 0.00012 -9.02439 198.589 1.09E-173 1.33E+165 0.963755 0.998648 Operations and Procedures Other operations on lip T 379101 464 378637 5.52E-05 -9.80545 198.808 3.26E-174 9.34E+164 0.960663 0.998648 Operations and Procedures Surgical removal of tooth T 379101 5408 373693 0.485 -0.722725 1.00374 0.0679 3.47 0.471506 0.998648 Operations and Procedures Simple extraction of tooth T 379101 2335 376766 7.90E-05 -9.44656 73.4007 2.62E-67 2.38E+58 0.897596 0.998648 Operations and Procedures Preprosthetic oral surgery T 379101 274 378827 9.75E-05 -9.23565 198.494 1.07E-173 8.92E+164 0.962889 0.998648 Operations and Procedures Surgery on apex of tooth T 379101 1147 377954 6.38E-05 -9.65988 120.597 1.41E-107 2.88E+98 0.936157 0.998648 Operations and Procedures Other operations on tooth T 379101 286 378815 8.95E-05 -9.32172 198.89 4.50E-174 1.78E+165 0.962618 0.998648 Operations and Procedures Extirpation of lesion of tongue T 379101 690 378411 0.000101 -9.20507 120.905 1.22E-107 8.29E+98 0.939312 0.998648 Operations and Procedures Incision of tongue T 379101 994 378107 6.86E-05 -9.58722 120.84 9.45E-108 4.98E+98 0.936763 0.998648 Operations and Procedures Extirpation of lesion of palate T 379101 297 378804 8.87E-05 -9.33053 198.68 6.73E-174 1.17E+165 0.962543 0.998648 Operations and Procedures Other operations on palate T 379101 1051 378050 6.48E-05 -9.64354 118.999 3.30E-106 1.28E+97 0.935411 0.998648 Operations and Procedures Excision of tonsil T 379101 1168 377933 6.35E-05 -9.66455 118.605 6.98E-106 5.77E+96 0.935056 0.998648 Operations and Procedures Other operations on tonsil T 379101 503 378598 4.95E-05 -9.91365 198.619 4.23E-174 5.79E+164 0.960192 0.998648 Operations and Procedures Extirpation of lesion of other part of mouth T 379101 688 378413 0.000105 -9.16329 120.515 2.73E-107 4.03E+98 0.939391 0.998648 Operations and Procedures Other operations on mouth T 379101 1260 377841 5.72E-05 -9.76881 120.218 2.67E-107 1.23E+98 0.935236 0.998648 Operations and Procedures Excision of salivary gland T 379101 935 378166 7.17E-05 -9.54241 120.917 8.49E-108 6.06E+98 0.937099 0.998648 Operations and Procedures Excision of oesophagus and stomach T 379101 219 378882 0.00012 -9.02913 190.448 9.25E-167 1.55E+158 0.962187 0.998648 Operations and Procedures Other therapeutic operations on oesophagus T 379101 331 378770 7.58E-05 -9.48714 194.571 1.81E-170 3.18E+161 0.961111 0.998648 Operations and Procedures Diagnostic fibreoptic endoscopic examination of oesophagus T 379101 1468 377633 4.61E-05 -9.98492 120.287 1.88E-107 1.13E+98 0.933844 0.998648 Operations and Procedures Other operations on oesophagus T 379101 1839 377262 1.55 0.437119 1.00409 0.216 11.1 0.663316 0.998648 Operations and Procedures Repair of diaphragmatic hernia T 379101 276 378825 9.06E-05 -9.30889 198.656 7.21E-174 1.14E+165 0.962625 0.998648 Operations and Procedures Antireflux operations T 379101 820 378281 8.29E-05 -9.39749 121.062 7.39E-108 9.31E+98 0.938126 0.998648 Operations and Procedures Other connection of stomach to jejunum T 379101 256 378845 0.000106 -9.15058 197.751 4.98E-173 2.26E+164 0.963093 0.998648 Operations and Procedures Artificial opening into stomach T 379101 356 378745 7.06E-05 -9.55835 196.041 9.45E-172 5.28E+162 0.961113 0.998648 Operations and Procedures Extirpation of lesion of upper gastrointestinal tract T 379101 1015 378086 2.67 0.98182 1.00565 0.372 19.2 0.328915 0.998648 Operations and Procedures Therapeutic fibreoptic gastrointestinal tract T 379101 1244 377857 5.49E-05 -9.81003 119.568 9.15E-107 3.30E+97 0.93461 0.998648 Operations and Procedures Examination of upper gastrointestinal tract T 379101 65264 313837 0.91 -0.093923 0.233427 0.576 1.44 0.687414 0.998648 Operations and Procedures Intubation of stomach T 379101 329 378772 8.37E-05 -9.38787 194.59 1.93E-170 3.64E+161 0.961522 0.998648 Operations and Procedures Artificial opening into jejunum T 379101 294 378807 8.57E-05 -9.36458 194.078 5.38E-170 1.37E+161 0.961516 0.998648 Operations and Procedures Excision of ileum T 379101 732 378369 3.77 1.32688 1.00481 0.526 27 0.186659 0.998648 Operations and Procedures Creation of artificial opening into ileum T 379101 1023 378078 2.57 0.944013 1.00484 0.359 18.4 0.347493 0.998648 Operations and Procedures Attention to artificial opening into ileum T 379101 998 378103 2.61 0.958374 1.00478 0.364 18.7 0.340178 0.998648 Operations and Procedures Emergency excision of appendix T 379101 2570 376531 7.00E-05 -9.56688 73.3144 2.75E-67 1.78E+58 0.896178 0.998648 Operations and Procedures Total excision of colon and rectum T 379101 212 378889 0.00012 -9.03085 197.78 5.30E-173 2.70E+164 0.96358 0.998648 Operations and Procedures Extended excision of right hemicolon T 379101 250 378851 0.000101 -9.19899 194.321 3.94E-170 2.60E+161 0.962243 0.998648 Operations and Procedures Other excision of right hemicolon T 379101 1421 377680 4.85E-05 -9.93416 119.333 1.28E-106 1.84E+97 0.933655 0.998648 Operations and Procedures Excision of left hemicolon T 379101 330 378771 8.21E-05 -9.40756 193.43 1.83E-169 3.68E+160 0.96121 0.998648 Operations and Procedures Other excision of colon T 379101 242 378859 0.000103 -9.18372 197.606 6.40E-173 1.65E+164 0.962932 0.998648 Operations and Procedures Other exteriorisation of colon T 379101 934 378167 2.91 1.0672 1.00498 0.406 20.8 0.288272 0.998648 Operations and Procedures Endoscopic extirpation of lesion of colon T 379101 14469 364632 1.33 0.283029 0.390943 0.617 2.86 0.469088 0.998648 Operations and Procedures Diagnostic endoscopic examination of colon T 379101 48889 330212 0.881 -0.127092 0.266608 0.522 1.49 0.633575 0.998648 Operations and Procedures Endoscopic of lower bowel T 379101 3536 375565 5.19E-05 -9.86578 72.359 1.32E-66 2.04E+57 0.891549 0.998648 Operations and Procedures Examination of sigmoid colon T 379101 2690 376411 6.93E-05 -9.57668 73.1253 3.94E-67 1.22E+58 0.895805 0.998648 Operations and Procedures Excision of rectum T 379101 2290 376811 8.13E-05 -9.41722 72.1698 3.01E-66 2.20E+57 0.896181 0.998648 Operations and Procedures Fixation of rectum for prolapse T 379101 293 378808 9.67E-05 -9.24348 187.941 1.02E-164 9.21E+155 0.960774 0.998648 Operations and Procedures Other operations on rectum through anus T 379101 648 378453 0.000102 -9.18831 119.873 9.37E-107 1.12E+98 0.938902 0.998648 Operations and Procedures Perineal operations for prolapse of rectum T 379101 257 378844 0.000106 -9.15606 195.907 1.84E-171 6.07E+162 0.962723 0.998648 Operations and Procedures Manipulation of rectum T 379101 1760 377341 3.84E-05 -10.1665 120.949 4.27E-108 3.46E+98 0.933012 0.998648 Operations and Procedures Other operations on rectum T 379101 894 378207 8.86E-05 -9.3314 118.813 6.48E-106 1.21E+97 0.9374 0.998648 Operations and Procedures Excision of lesion of anus T 379101 2708 376393 1.99 0.688376 0.712438 0.493 8.04 0.333931 0.998648 Operations and Procedures Destruction of haemorrhoid T 379101 5384 373717 3.48E-05 -10.2659 73.2182 1.65E-67 7.35E+57 0.888495 0.998648 Operations and Procedures Other operations on haemorrhoid T 379101 276 378825 8.47E-05 -9.37609 197.718 4.24E-173 1.69E+164 0.962177 0.998648 Operations and Procedures Dilation of anal sphincter T 379101 444 378657 6.09E-05 -9.70622 198.801 3.65E-174 1.02E+165 0.96106 0.998648 Operations and Procedures Other operations on perianal region T 379101 1153 377948 5.77E-05 -9.75973 119.776 6.40E-107 5.21E+97 0.935058 0.998648 Operations and Procedures Other operations on anus T 379101 1643 377458 4.09E-05 -10.1048 121.146 3.09E-108 5.41E+98 0.933525 0.998648 Operations and Procedures Drainage through perineal region T 379101 1052 378049 6.53E-05 -9.63716 119.268 1.96E-106 2.18E+97 0.935599 0.998648 Operations and Procedures Excision of pilonidal sinus T 379101 253 378848 0.000105 -9.15736 191.993 3.94E-168 2.82E+159 0.961958 0.998648 Operations and Procedures Other operations on pilonidal sinus T 379101 206 378895 5.18E-05 -9.86828 314.749 6.23E-273 4.31E+263 0.974988 0.998648 Operations and Procedures Other operations on bowel T 379101 379 378722 7.29E-05 -9.52703 197.511 5.47E-173 9.71E+163 0.961529 0.998648 Operations and Procedures Other puncture of liver T 379101 403 378698 6.21E-05 -9.68716 199.223 1.63E-174 2.37E+165 0.961218 0.998648 Operations and Procedures Other open operations on bile duct T 379101 1260 377841 2.3 0.832438 1.00485 0.321 16.5 0.407432 0.998648 Operations and Procedures Endoscopic incision of sphincter of Oddi T 379101 1801 377300 3.97E-05 -10.1344 119.344 1.03E-106 1.54E+97 0.932326 0.998648 Operations and Procedures Endoscopic retrograde placement of prosthesis in bile duct T 379101 560 378541 4.64E-05 -9.97721 195.611 1.44E-171 1.49E+162 0.959321 0.998648 Operations and Procedures Other therapeutic operations on bile duct T 379101 284 378817 9.28E-05 -9.28532 196.342 6.88E-172 1.25E+163 0.962281 0.998648 Operations and Procedures Examination of bile duct and pancreatic duct T 379101 2192 376909 8.88E-05 -9.32955 72.433 1.96E-66 4.02E+57 0.897514 0.998648 Operations and Procedures Diagnostic endoscopic retrograde examination of bile duct T 379101 309 378792 8.61E-05 -9.35971 196.801 2.60E-172 2.85E+163 0.962067 0.998648 Operations and Procedures Diagnostic retrograde exam pancreatic duct T 379101 208 378893 0.000126 -8.97881 196.16 1.34E-171 1.19E+163 0.963491 0.998648 Operations and Procedures Endoscopic ultrasound examination of bile duct T 379101 228 378873 0.000117 -9.05018 197.201 1.62E-172 8.52E+163 0.963395 0.998648 Operations and Procedures Total excision of spleen T 379101 281 378820 8.56E-05 -9.36529 198.431 1.06E-173 6.93E+164 0.962357 0.998648 Operations and Procedures Plastic repair of mitral valve T 379101 528 378573 4.87E-05 -9.92975 192.812 3.65E-169 6.49E+159 0.958927 0.998648 Operations and Procedures Plastic repair of aortic valve T 379101 1074 378027 2.44 0.891593 1.00697 0.339 17.6 0.375931 0.998648 Operations and Procedures Other open operations on valve of heart T 379101 301 378800 8.49E-05 -9.37432 192.038 2.90E-168 2.48E+159 0.961067 0.998648 Operations and Procedures Saphenous vein graft replacement of coronary artery T 379101 3223 375878 6.30E-05 -9.67267 67.5264 2.09E-62 1.90E+53 0.886098 0.998648 Operations and Procedures Other autograft replacement of coronary artery T 379101 496 378605 5.36E-05 -9.83429 184.318 6.83E-162 4.20E+152 0.957449 0.998648 Operations and Procedures Connection of thoracic artery to coronary artery T 379101 3408 375693 5.88E-05 -9.74055 67.5104 2.01E-62 1.72E+53 0.885278 0.998648 Operations and Procedures Transluminal balloon angioplasty of coronary artery T 379101 2913 376188 6.79E-05 -9.5981 69.0828 1.06E-63 4.33E+54 0.889501 0.998648 Operations and Procedures Other therapeutic transluminal operations on coronary artery T 379101 858 378243 7.77E-05 -9.46211 114.536 2.49E-102 2.43E+93 0.93416 0.998648 Operations and Procedures Diagnostic transluminal operations on coronary artery T 379101 808 378293 8.76E-05 -9.34329 117.315 1.21E-104 6.35E+95 0.936521 0.998648 Operations and Procedures Transluminal heart assist operations T 379101 275 378826 9.65E-05 -9.24635 190.199 1.21E-166 7.67E+157 0.961227 0.998648 Operations and Procedures Other therapeutic transluminal operations on heart T 379101 1372 377729 1.89 0.636257 1.00431 0.264 13.5 0.526388 0.998648 Operations and Procedures Diagnostic transluminal operations on heart T 379101 1107 377994 5.94E-05 -9.73109 120.188 2.94E-107 1.20E+98 0.935469 0.998648 Operations and Procedures Cardioverter defibrillator introduced through the vein T 379101 599 378502 4.32E-05 -10.0508 189.073 4.93E-166 3.78E+156 0.957606 0.998648 Operations and Procedures Cardiac pacemaker system introduced through vein T 379101 2286 376815 1.14 0.135174 1.00679 0.159 8.24 0.893195 0.998648 Operations and Procedures Other cardiac pacemaker system T 379101 1141 377960 5.99E-05 -9.72283 115.758 1.75E-103 2.05E+94 0.933062 0.998648 Operations and Procedures Therapeutic transluminal operations on heart T 379101 862 378239 7.72E-05 -9.46909 118.299 1.55E-105 3.85E+96 0.936202 0.998648 Operations and Procedures Contrast radiology of heart T 379101 21382 357719 0.597 -0.516444 0.459947 0.242 1.47 0.261508 0.998648 Operations and Procedures Catheterisation of heart T 379101 776 378325 8.98E-05 -9.31771 117.591 7.21E-105 1.12E+96 0.936843 0.998648 Operations and Procedures Other operations on heart T 379101 733 378368 3.56 1.26864 1.00453 0.496 25.5 0.206617 0.998648 Operations and Procedures Percutaneous transluminal balloon T 379101 5594 373507 0.449 -0.801083 1.00626 0.0625 3.23 0.425977 0.998648 Operations and Procedures Other replacement of aneurysmal segment of aorta T 379101 295 378806 9.84E-05 -9.22642 182.772 2.60E-160 3.73E+151 0.95974 0.998648 Operations and Procedures Transluminal operations on aorta T 379101 858 378243 3.17 1.15305 1.00764 0.44 22.8 0.252493 0.998648 Operations and Procedures Reconstruction of carotid artery T 379101 506 378595 5.48E-05 -9.8126 187.541 1.26E-164 2.38E+155 0.958272 0.998648 Operations and Procedures Operations on aneurysm of cerebral artery T 379101 201 378900 0.000138 -8.88855 197.738 6.63E-173 2.87E+164 0.964146 0.998648 Operations and Procedures Transluminal operations on cerebral artery T 379101 1001 378100 2.74 1.00855 1.00425 0.383 19.6 0.315243 0.998648 Operations and Procedures Transluminal operations on renal artery T 379101 241 378860 0.000101 -9.20416 198.175 2.05E-173 4.93E+164 0.962956 0.998648 Operations and Procedures Other bypass of femoral artery T 379101 274 378827 0.000106 -9.15284 184.902 4.30E-162 2.61E+153 0.96052 0.998648 Operations and Procedures Reconstruction of femoral artery T 379101 231 378870 4.68E-05 -9.9702 299.197 9.74E-260 2.25E+250 0.973417 0.998648 Operations and Procedures Transluminal operations on femoral artery T 379101 1076 378025 6.86E-05 -9.58674 114.98 9.20E-103 5.12E+93 0.933552 0.998648 Operations and Procedures Excision of other artery T 379101 498 378603 5.54E-05 -9.80098 190.3 5.71E-167 5.37E+157 0.958925 0.998648 Operations and Procedures Other open operations on other artery T 379101 320 378781 7.40E-05 -9.51094 198.504 7.93E-174 6.91E+164 0.961785 0.998648 Operations and Procedures Therapeutic transluminal operations on other artery T 379101 774 378327 9.00E-05 -9.31554 120.903 1.10E-107 7.40E+98 0.938584 0.998648 Operations and Procedures Arteriovenous shunt T 379101 297 378804 8.29E-05 -9.3979 196.497 4.54E-172 1.51E+163 0.961854 0.998648 Operations and Procedures Endovascular placement of stent T 379101 370 378731 7.09E-05 -9.55478 190.927 2.14E-167 2.35E+158 0.960087 0.998648 Operations and Procedures Other operations on vena cava T 379101 207 378894 0.000114 -9.076 197.819 4.69E-173 2.79E+164 0.963406 0.998648 Operations and Procedures Combined operations on varicose vein of leg T 379101 1623 377478 1.72 0.542986 1.004 0.241 12.3 0.588629 0.998648 Operations and Procedures Ligation of varicose vein of leg T 379101 5765 373336 1.5 0.404823 0.584624 0.477 4.71 0.488654 0.998648 Operations and Procedures Injection into varicose vein of leg T 379101 823 378278 9.53E-05 -9.25887 119.38 2.29E-106 3.96E+97 0.93818 0.998648 Operations and Procedures Other operations on varicose vein of leg T 379101 6971 372130 1.24 0.211123 0.584601 0.393 3.88 0.717995 0.998648 Operations and Procedures Transluminal operations on varicose vein of leg T 379101 1198 377903 5.94E-05 -9.73177 120.789 9.03E-108 3.90E+98 0.935785 0.998648 Operations and Procedures Other vein related operations T 379101 4293 374808 1.86 0.621912 0.584344 0.593 5.85 0.287197 0.998648 Operations and Procedures Therapeutic transluminal operations on vein T 379101 314 378787 7.23E-05 -9.53464 198.95 3.23E-174 1.62E+165 0.961776 0.998648 Operations and Procedures Diagnostic transluminal operations on vein T 379101 931 378170 7.43E-05 -9.50706 120.413 2.36E-107 2.34E+98 0.937069 0.998648 Operations and Procedures Other therapeutic transluminal operations on vein T 379101 1371 377730 1.83 0.604975 1.00429 0.256 13.1 0.546914 0.998648 Operations and Procedures Transplantation of kidney T 379101 266 378835 9.08E-05 -9.30729 197.834 3.62E-173 2.28E+164 0.962477 0.998648 Operations and Procedures Total excision of kidney T 379101 1063 378038 6.32E-05 -9.66962 119.635 9.23E-107 4.32E+97 0.93558 0.998648 Operations and Procedures Therapeutic endoscopic operations on calculus of kidney T 379101 417 378684 5.95E-05 -9.72893 196.641 2.46E-172 1.44E+163 0.96054 0.998648 Operations and Procedures Percutaneous puncture of kidney T 379101 1437 377664 4.63E-05 -9.97998 120.048 3.01E-107 7.12E+97 0.933746 0.998648 Operations and Procedures Extracorporeal fragmentation of calculus of kidney T 379101 1421 377680 1.78 0.576125 1.00485 0.248 12.8 0.566413 0.998648 Operations and Procedures Other operations on kidney T 379101 281 378820 9.18E-05 -9.29576 197.132 1.45E-172 5.82E+163 0.96239 0.998648 Operations and Procedures Urinary diversion T 379101 327 378774 7.83E-05 -9.4553 193.641 1.16E-169 5.30E+160 0.961056 0.998648 Operations and Procedures Therapeutic ureteroscopic operations on ureter T 379101 1338 377763 5.01E-05 -9.90126 119.369 1.23E-106 2.04E+97 0.933894 0.998648 Operations and Procedures Other endoscopic removal of calculus from ureter T 379101 242 378859 0.000101 -9.19546 196.735 3.49E-172 2.96E+163 0.96272 0.998648 Operations and Procedures Other therapeutic endoscopic operations on ureter T 379101 1932 377169 9.27E-05 -9.28645 72.9141 7.97E-67 1.08E+58 0.898654 0.998648 Operations and Procedures Diagnostic endoscopic examination of ureter T 379101 1627 377474 1.61 0.478645 1.00441 0.225 11.6 0.633689 0.998648 Operations and Procedures Extracorporeal fragmentation of calculus of ureter T 379101 563 378538 4.20E-05 -10.0781 193.821 4.36E-170 4.04E+160 0.958531 0.998648 Operations and Procedures Total excision of bladder T 379101 315 378786 8.14E-05 -9.41617 190.968 2.27E-167 2.92E+158 0.960674 0.998648 Operations and Procedures Other repair of bladder T 379101 216 378885 0.000123 -9.00324 198.186 2.46E-173 6.16E+164 0.963766 0.998648 Operations and Procedures Endoscopic extirpation of lesion of bladder T 379101 2389 376712 8.09E-05 -9.42286 70.1885 1.45E-64 4.50E+55 0.893204 0.998648 Operations and Procedures Endoscopic operations to increase capacity of bladder T 379101 1067 378034 7.15E-05 -9.54628 118.755 5.86E-106 8.72E+96 0.93593 0.998648 Operations and Procedures Other therapeutic endoscopic operations on bladder T 379101 557 378544 4.57E-05 -9.99407 192.51 6.19E-169 3.37E+159 0.958597 0.998648 Operations and Procedures Diagnostic endoscopic examination of bladder T 379101 30109 348992 1.06 0.059458 0.304113 0.585 1.93 0.844993 0.998648 Operations and Procedures Other operations on bladder T 379101 1638 377463 1.6 0.468659 1.00512 0.223 11.5 0.64102 0.998648 Operations and Procedures Abdominal operations to support outlet of female bladder T 379101 1021 378080 8.57E-08 -16.2727 3625.47 0 Inf 0.996419 0.998648 Operations and Procedures Vaginal operations to support outlet of female bladder T 379101 3234 375867 6.82E-08 -16.5002 2210.83 0 Inf 0.994045 0.998648 Operations and Procedures Therapeutic on outlet of female bladder T 379101 299 378802 0.000112 -9.09286 182.002 1.34E-159 9.42E+150 0.960154 0.998648 Operations and Procedures Open excision of prostate T 379101 2046 377055 1.14 0.132379 1.0108 0.157 8.28 0.895803 0.998648 Operations and Procedures Endoscopic resection of outlet of male bladder T 379101 3901 375200 0.634 -0.456466 1.01268 0.087 4.61 0.652169 0.998648 Operations and Procedures Other therapeutic on outlet of male bladder T 379101 850 378251 2.95 1.08033 1.0102 0.407 21.3 0.284876 0.998648 Operations and Procedures Other operations on outlet of male bladder T 379101 6418 372683 1.56 0.445483 0.521329 0.562 4.34 0.392821 0.998648 Operations and Procedures Therapeutic endoscopic operations on urethra T 379101 2234 376867 8.13E-05 -9.41785 73.1155 4.71E-67 1.40E+58 0.89751 0.998648 Operations and Procedures Diagnostic endoscopic examination of urethra T 379101 369 378732 6.76E-05 -9.6026 190.288 7.13E-167 6.40E+157 0.959753 0.998648 Operations and Procedures Other operations on urethra T 379101 1489 377612 4.79E-05 -9.94562 120.029 3.24E-107 7.10E+97 0.933963 0.998648 Operations and Procedures Operations on urethral orifice T 379101 464 378637 5.35E-05 -9.83573 191.839 2.70E-168 1.06E+159 0.95911 0.998648 Operations and Procedures Other operations on scrotum T 379101 203 378898 4.36E-08 -16.9477 9907.79 0 Inf 0.998635 0.998648 Operations and Procedures Other excision of testis T 379101 508 378593 4.89E-08 -16.8326 6003.28 0 Inf 0.997763 0.998648 Operations and Procedures Operations on hydrocele sac T 379101 1029 378072 6.64E-08 -16.528 3643.01 0 Inf 0.99638 0.998648 Operations and Procedures Operations on epididymis T 379101 1069 378032 2.32 0.843436 1.00797 0.322 16.8 0.402725 0.998648 Operations and Procedures Excision of vas deferens T 379101 4286 374815 1.81 0.593321 0.606944 0.551 5.95 0.328295 0.998648 Operations and Procedures Extirpation of lesion of penis T 379101 221 378880 4.10E-08 -17.0106 9928.78 0 Inf 0.998633 0.998648 Operations and Procedures Plastic operations on penis T 379101 394 378707 6.28E-08 -16.5835 6024.54 0 Inf 0.997804 0.998648 Operations and Procedures Operations on prepuce T 379101 2323 376778 2.87E-08 -17.3681 3651.94 0 Inf 0.996205 0.998648 Operations and Procedures Other operations on penis T 379101 452 378649 5.62E-08 -16.6945 5965.72 0 Inf 0.997767 0.998648 Operations and Procedures Other upper digestive tract T 379101 488 378613 4.87E-05 -9.92945 197.272 5.84E-173 4.06E+163 0.959856 0.998648 Operations and Procedures Branch of external carotid artery T 379101 271 378830 1.00E-04 -9.20657 190.771 4.11E-167 2.45E+158 0.961509 0.998648 Operations and Procedures Other leg region T 379101 287 378814 9.70E-05 -9.24121 194.81 1.45E-170 6.49E+161 0.962165 0.998648 Operations and Procedures Other lymph node T 379101 2930 376171 0.962 -0.038861 1.00664 0.134 6.92 0.969205 0.998648 Operations and Procedures Body region T 379101 6404 372697 1.66 0.506208 0.508393 0.612 4.49 0.319395 0.998648 Operations and Procedures Excision of bone T 379101 3651 375450 0.717 -0.332121 1.0036 0.1 5.13 0.740697 0.998648 Operations and Procedures Operations on Bartholin gland T 379101 599 378502 5.13E-08 -16.7853 5974.92 0 Inf 0.997759 0.998648 Operations and Procedures Excision of vulva T 379101 1147 377954 2.64 0.970377 1.00797 0.366 19 0.335695 0.998648 Operations and Procedures Other operations on vulva T 379101 1300 377801 6.62E-08 -16.5305 3636.81 0 Inf 0.996373 0.998648 Operations and Procedures Other operations on female perineum T 379101 887 378214 8.98E-08 -16.2261 3651.73 0 Inf 0.996455 0.998648 Operations and Procedures Extirpation of lesion of vagina T 379101 675 378426 4.42E-08 -16.9353 6018.89 0 Inf 0.997755 0.998648 Operations and Procedures Other repair of prolapse of vagina T 379101 7298 371803 3.02E-08 -17.3141 2175.08 0 Inf 0.993649 0.998648 Operations and Procedures Repair of vault of vagina T 379101 1152 377949 7.65E-08 -16.3863 3589.57 0 Inf 0.996358 0.998648 Operations and Procedures Other repair of vagina T 379101 332 378769 9.17E-08 -16.2051 6003.23 0 Inf 0.997846 0.998648 Operations and Procedures Exploration of vagina T 379101 1868 377233 4.42E-08 -16.9355 3624.09 0 Inf 0.996271 0.998648 Operations and Procedures Other operations on vagina T 379101 544 378557 5.46E-08 -16.7241 6015.45 0 Inf 0.997782 0.998648 Operations and Procedures Excision of cervix uteri T 379101 3167 375934 6.86E-08 -16.4947 2208.72 0 Inf 0.994041 0.998648 Operations and Procedures Destruction of lesion of cervix uteri T 379101 2136 376965 3.93E-08 -17.0532 3628.7 0 Inf 0.99625 0.998648 Operations and Procedures Biopsy of cervix uteri T 379101 1749 377352 4.65E-08 -16.8844 3629.55 0 Inf 0.996288 0.998648 Operations and Procedures Other operations on cervix uteri T 379101 247 378854 1.31E-07 -15.8444 5991.08 0 Inf 0.99789 0.998648 Operations and Procedures Abdominal excision of uterus T 379101 9231 369870 6.53E-08 -16.5447 1332.72 0 Inf 0.990095 0.998648 Operations and Procedures Vaginal excision of uterus T 379101 4716 374385 4.59E-08 -16.8961 2201.81 0 Inf 0.993877 0.998648 Operations and Procedures Other open operations on uterus T 379101 285 378816 1.16E-07 -15.9722 5897.56 0 Inf 0.997839 0.998648 Operations and Procedures Curettage of uterus T 379101 6842 372259 1.4 0.339831 0.592123 0.44 4.48 0.566022 0.998648 Operations and Procedures Other evacuation of contents of uterus T 379101 2583 376518 5.80E-05 -9.75549 102.326 4.59E-92 7.33E+82 0.924047 0.998648 Operations and Procedures Intrauterine contraceptive device T 379101 5122 373979 1.24 0.215659 0.722507 0.301 5.11 0.765331 0.998648 Operations and Procedures Introduction of abortifacient into uterine cavity T 379101 623 378478 9.76E-08 -16.142 5461.54 0 Inf 0.997642 0.998648 Operations and Procedures Other vaginal operations on uterus T 379101 1552 377549 1.9 0.63972 1.01106 0.261 13.8 0.526916 0.998648 Operations and Procedures Therapeutic endoscopic operations on uterus T 379101 6827 372274 1.28 0.24871 0.59037 0.403 4.08 0.673552 0.998648 Operations and Procedures Diagnostic endoscopic examination of uterus T 379101 20331 358770 0.998 -0.001677 0.398319 0.457 2.18 0.996641 0.998648 Operations and Procedures Other operations on uterus T 379101 1103 377998 2.51 0.919488 1.00851 0.347 18.1 0.361912 0.998648 Operations and Procedures Bilateral excision of adnexa of uterus T 379101 8743 370358 6.75E-08 -16.5112 1334.29 0 Inf 0.990127 0.998648 Operations and Procedures Unilateral excision of adnexa of uterus T 379101 1862 377239 4.66E-08 -16.8808 3606.22 0 Inf 0.996265 0.998648 Operations and Procedures Other excision of adnexa of uterus T 379101 224 378877 4.82E-08 -16.8481 9818.83 0 Inf 0.998631 0.998648 Operations and Procedures Endoscopic bilateral occlusion of fallopian tubes T 379101 2687 376414 4.57E-08 -16.9003 3469.03 0 Inf 0.996113 0.998648 Operations and Procedures Diagnostic endoscopic examination of fallopian tube T 379101 293 378808 6.87E-08 -16.4928 9376.31 0 Inf 0.998597 0.998648 Operations and Procedures Partial excision of ovary T 379101 433 378668 8.76E-08 -16.2502 5877.98 0 Inf 0.997794 0.998648 Operations and Procedures Therapeutic endoscopic operations on ovary T 379101 717 378384 4.85E-08 -16.8427 5838.83 0 Inf 0.997698 0.998648 Operations and Procedures Other examination of female genital tract T 379101 3998 375103 1.52 0.41764 0.71785 0.372 6.2 0.560706 0.998648 Operations and Procedures Other operations on amniotic cavity T 379101 308 378793 5.06E-08 -16.7997 9097.69 0 Inf 0.998527 0.998648 Operations and Procedures Surgical induction of labour T 379101 2296 376805 8.05E-08 -16.3347 3184.06 0 Inf 0.995907 0.998648 Operations and Procedures Other induction of labour T 379101 2732 376369 6.21E-08 -16.5944 3188.66 0 Inf 0.995848 0.998648 Operations and Procedures Elective caesarean delivery T 379101 1697 377404 9.19E-08 -16.2029 3246.12 0 Inf 0.996017 0.998648 Operations and Procedures Other caesarean delivery T 379101 1946 377155 8.40E-08 -16.2919 3219 0 Inf 0.995962 0.998648 Operations and Procedures Forceps cephalic delivery T 379101 705 378396 8.80E-08 -16.2463 5307.56 0 Inf 0.997558 0.998648 Operations and Procedures Vacuum delivery T 379101 1205 377896 5.08E-08 -16.7944 5291.17 0 Inf 0.997467 0.998648 Operations and Procedures Normal delivery T 379101 6515 372586 0.649 -0.431911 1.03481 0.0854 4.93 0.6764 0.998648 Operations and Procedures Other operations to facilitate delivery T 379101 2119 376982 7.78E-08 -16.3691 3204.11 0 Inf 0.995924 0.998648 Operations and Procedures Removal of products of delivered uterus T 379101 339 378762 6.21E-08 -16.5953 8831.07 0 Inf 0.998501 0.998648 Operations and Procedures Other operations on delivered uterus T 379101 225 378876 9.65E-08 -16.154 8912.07 0 Inf 0.998554 0.998648 Operations and Procedures Repair of obstetric laceration T 379101 3617 375484 1.27 0.236602 1.03527 0.167 9.64 0.819226 0.998648 Operations and Procedures Plastic excision of skin of head or neck T 379101 208 378893 0.000121 -9.02025 198.304 1.92E-173 7.63E+164 0.963719 0.998648 Operations and Procedures Plastic excision of skin of abdominal wall T 379101 228 378873 0.000144 -8.84251 189.335 9.88E-166 2.11E+157 0.96275 0.998648 Operations and Procedures Other excision of skin T 379101 205 378896 0.000137 -8.89907 198.083 3.34E-173 5.58E+164 0.964166 0.998648 Operations and Procedures Microscopically controlled excision of lesion of skin T 379101 920 378181 7.09E-05 -9.55374 119.018 3.47E-106 1.45E+97 0.936021 0.998648 Operations and Procedures Other excision of lesion of skin T 379101 31445 347656 0.665 -0.408006 0.364251 0.326 1.36 0.262662 0.998648 Operations and Procedures Curettage of lesion of skin T 379101 1788 377313 3.69E-05 -10.2065 119.575 6.07E-107 2.25E+97 0.931978 0.998648 Operations and Procedures Photodestruction of lesion of skin T 379101 418 378683 6.43E-05 -9.65167 195.946 1.04E-171 3.99E+162 0.960715 0.998648 Operations and Procedures Other destruction of lesion of skin of head or neck T 379101 325 378776 7.47E-05 -9.50195 198.658 5.92E-174 9.43E+164 0.961851 0.998648 Operations and Procedures Other destruction of lesion of skin of other site T 379101 282 378819 8.81E-05 -9.33708 198.13 1.96E-173 3.95E+164 0.962413 0.998648 Operations and Procedures Punch biopsy of skin T 379101 3326 375775 1.66 0.506625 0.713418 0.41 6.72 0.477618 0.998648 Operations and Procedures Shave biopsy of skin T 379101 626 378475 0.000106 -9.15579 120.289 4.28E-107 2.60E+98 0.939328 0.998648 Operations and Procedures Other biopsy of skin T 379101 1597 377504 1.67 0.514776 1.00435 0.234 12 0.608269 0.998648 Operations and Procedures Flap operations to relax contracture of skin T 379101 656 378445 0.000102 -9.18606 118.985 5.35E-106 1.96E+97 0.938462 0.998648 Operations and Procedures Other local flap of skin T 379101 1956 377145 1.39 0.327489 1.005 0.194 9.95 0.744529 0.998648 Operations and Procedures Split autograft of skin T 379101 1318 377783 1.99 0.687173 1.00461 0.278 14.2 0.493962 0.998648 Operations and Procedures Other autograft of skin T 379101 1822 377279 1.44 0.367112 1.00533 0.201 10.4 0.714988 0.998648 Operations and Procedures Suture of skin of head or neck T 379101 774 378327 8.59E-05 -9.36229 119.945 6.84E-107 1.08E+98 0.937784 0.998648 Operations and Procedures Suture of skin of other site T 379101 2266 376835 7.82E-05 -9.45667 73.0057 5.61E-67 1.09E+58 0.896936 0.998648 Operations and Procedures Removal of other inorganic substance from skin T 379101 431 378670 5.95E-05 -9.72907 198.708 4.28E-174 8.29E+164 0.96095 0.998648 Operations and Procedures Opening of skin T 379101 3649 375452 1.47 0.385143 0.712447 0.364 5.94 0.588789 0.998648 Operations and Procedures Insertion of skin expander into subcutaneous tissue T 379101 446 378655 7.19E-05 -9.54069 183.324 6.43E-161 8.04E+151 0.958495 0.998648 Operations and Procedures Attention to skin expander in subcutaneous tissue T 379101 431 378670 7.42E-05 -9.50928 183.843 2.40E-161 2.29E+152 0.958748 0.998648 Operations and Procedures Introduction of therapeutic substance into subcutaneous tissue T 379101 610 378491 4.67E-05 -9.97182 194.477 1.34E-170 1.63E+161 0.959106 0.998648 Operations and Procedures Introduction of substance into skin T 379101 217 378884 0.00011 -9.11202 198.702 8.02E-174 1.52E+165 0.963424 0.998648 Operations and Procedures Exploration of other skin of head or neck T 379101 445 378656 5.55E-05 -9.79989 197.176 8.02E-173 3.83E+163 0.96036 0.998648 Operations and Procedures Exploration of other skin of other site T 379101 4464 374637 1.15 0.140371 0.712729 0.285 4.65 0.843868 0.998648 Operations and Procedures Other operations on skin T 379101 1061 378040 7.20E-05 -9.53942 118.9 4.44E-106 1.17E+97 0.936054 0.998648 Operations and Procedures Other operations on subcutaneous tissue T 379101 494 378607 5.68E-05 -9.77547 196.548 2.82E-172 1.15E+163 0.960333 0.998648 Operations and Procedures Other operations on nail bed T 379101 686 378415 9.35E-05 -9.27768 119.953 7.32E-107 1.19E+98 0.93835 0.998648 Operations and Procedures Other operations on nail T 379101 396 378705 6.61E-05 -9.62469 198.596 5.91E-174 7.39E+164 0.961347 0.998648 Operations and Procedures Opening of chest T 379101 257 378844 0.000104 -9.17464 190.309 1.05E-166 1.02E+158 0.96155 0.998648 Operations and Procedures Primary repair of inguinal hernia T 379101 13724 365377 1.27 0.2403 0.398174 0.583 2.78 0.546173 0.998648 Operations and Procedures Repair of recurrent inguinal hernia T 379101 1175 377926 6.23E-05 -9.68361 111.043 1.87E-99 2.07E+90 0.930508 0.998648 Operations and Procedures Primary repair of femoral hernia T 379101 527 378574 5.08E-05 -9.88847 196.368 3.58E-172 7.20E+162 0.959838 0.998648 Operations and Procedures Primary repair of umbilical hernia T 379101 3099 376002 5.63E-05 -9.78399 71.9634 3.12E-66 1.02E+57 0.891855 0.998648 Operations and Procedures Primary repair of incisional hernia T 379101 1622 377479 4.20E-05 -10.077 120.31 1.64E-107 1.08E+98 0.933248 0.998648 Operations and Procedures Repair of recurrent incisional hernia T 379101 225 378876 0.000112 -9.09778 197.929 3.70E-173 3.38E+164 0.963338 0.998648 Operations and Procedures Repair of other hernia of abdominal wall T 379101 1344 377757 4.90E-05 -9.9233 121.07 4.30E-108 5.59E+98 0.934676 0.998648 Operations and Procedures Opening of abdomen T 379101 940 378161 7.39E-05 -9.51264 120.734 1.25E-107 4.36E+98 0.9372 0.998648 Operations and Procedures Other operations on anterior abdominal wall T 379101 600 378501 0.000112 -9.0928 121.044 1.04E-107 1.22E+99 0.940119 0.998648 Operations and Procedures Open drainage of peritoneum T 379101 297 378804 8.54E-05 -9.36855 199.068 3.03E-174 2.41E+165 0.962464 0.998648 Operations and Procedures Operations on omentum T 379101 1948 377153 4.22E-05 -10.0738 114.556 1.30E-102 1.37E+93 0.929926 0.998648 Operations and Procedures Other open operations on peritoneum T 379101 2184 376917 1.26 0.232692 1.00425 0.176 9.03 0.816766 0.998648 Operations and Procedures Therapeutic endoscopic operations on peritoneum T 379101 1599 377502 4.70E-05 -9.96576 117.985 1.74E-105 1.27E+96 0.932685 0.998648 Operations and Procedures Diagnostic endoscopic examination of peritoneum T 379101 4723 374378 0.658 -0.418743 1.00776 0.0913 4.74 0.677762 0.998648 Operations and Procedures Other drainage of peritoneal cavity T 379101 2011 377090 1.39 0.328408 1.00432 0.194 9.94 0.743671 0.998648 Operations and Procedures Excision of other fascia T 379101 2947 376154 6.49E-05 -9.6428 70.098 1.39E-64 3.03E+55 0.890587 0.998648 Operations and Procedures Division of fascia T 379101 394 378707 6.66E-05 -9.61678 192.229 1.57E-168 2.83E+159 0.9601 0.998648 Operations and Procedures Excision of ganglion T 379101 2429 376672 2.34 0.85135 0.712845 0.579 9.47 0.232361 0.998648 Operations and Procedures Operations on bursa T 379101 1825 377276 1.52 0.4157 1.00405 0.212 10.8 0.678858 0.998648 Operations and Procedures Transposition of tendon T 379101 795 378306 8.45E-05 -9.37919 120.989 8.68E-108 8.21E+98 0.938209 0.998648 Operations and Procedures Excision of tendon T 379101 253 378848 0.000102 -9.1932 198.422 1.28E-173 8.08E+164 0.963046 0.998648 Operations and Procedures Primary repair of tendon T 379101 2574 376527 0.979 -0.021592 1.00453 0.137 7.01 0.982851 0.998648 Operations and Procedures Adjustment to length of tendon T 379101 2142 376959 8.94E-05 -9.32242 72.4137 2.05E-66 3.90E+57 0.897565 0.998648 Operations and Procedures Other operations on sheath of tendon T 379101 2908 376193 0.929 -0.074055 1.00415 0.13 6.65 0.94121 0.998648 Operations and Procedures Other operations on tendon T 379101 780 378321 3.43 1.23139 1.00437 0.478 24.5 0.220185 0.998648 Operations and Procedures Excision of muscle T 379101 476 378625 5.02E-05 -9.89952 199.436 8.66E-175 2.91E+165 0.960411 0.998648 Operations and Procedures Repair of muscle T 379101 2257 376844 8.08E-05 -9.42338 72.8034 8.63E-67 7.57E+57 0.897013 0.998648 Operations and Procedures Biopsy of muscle T 379101 421 378680 5.74E-05 -9.76497 199.531 8.22E-175 4.01E+165 0.960967 0.998648 Operations and Procedures Other operations on muscle T 379101 238 378863 0.000105 -9.16094 199.388 1.99E-174 5.55E+165 0.963354 0.998648 Operations and Procedures Block dissection of lymph nodes T 379101 5157 373944 1.1 0.093985 0.714224 0.271 4.45 0.895308 0.998648 Operations and Procedures Sampling of lymph nodes T 379101 2952 376149 1.97 0.678013 0.717131 0.483 8.03 0.344428 0.998648 Operations and Procedures Excision or biopsy of lymph node T 379101 6160 372941 0.45 -0.797556 1.0043 0.0629 3.22 0.427112 0.998648 Operations and Procedures Operations on sentinel lymph node T 379101 1143 377958 2.52 0.925338 1.00749 0.35 18.2 0.35838 0.998648 Operations and Procedures Other operations on soft tissue T 379101 1277 377824 2.13 0.754358 1.00407 0.297 15.2 0.45247 0.998648 Operations and Procedures Diagnostic imaging of central nervous system T 379101 13682 365419 0.763 -0.270445 0.507886 0.282 2.06 0.594386 0.998648 Operations and Procedures Diagnostic imaging of abdomen T 379101 2458 376643 7.64E-05 -9.47919 72.8811 7.01E-67 8.33E+57 0.896516 0.998648 Operations and Procedures Diagnostic imaging of pelvis T 379101 1273 377828 2.04 0.714192 1.00418 0.285 14.6 0.476948 0.998648 Operations and Procedures Diagnostic imaging of heart T 379101 1244 377857 5.19E-05 -9.86662 119.733 6.25E-107 4.30E+97 0.934324 0.998648 Operations and Procedures Diagnostic imaging of vascular system T 379101 1073 378028 6.32E-05 -9.66972 120.403 2.05E-107 1.95E+98 0.93599 0.998648 Operations and Procedures Diagnostic imaging of genitourinary system T 379101 293 378808 9.48E-05 -9.26356 193.57 1.61E-169 5.58E+160 0.961831 0.998648 Operations and Procedures Diagnostic imaging of musculoskeletal system T 379101 820 378281 8.09E-05 -9.42266 120.905 9.80E-108 6.67E+98 0.93788 0.998648 Operations and Procedures Diagnostic imaging of digestive tract T 379101 243 378858 0.00012 -9.02635 195.271 7.28E-171 1.99E+162 0.963131 0.998648 Operations and Procedures Diagnostic electrocardiography T 379101 998 378103 2.8 1.02868 1.00602 0.389 20.1 0.306534 0.998648 Operations and Procedures Neuropsychology tests T 379101 256 378845 9.47E-05 -9.26494 198.9 4.67E-174 1.92E+165 0.962847 0.998648 Operations and Procedures Breath tests T 379101 412 378689 6.54E-05 -9.63567 198.422 8.22E-174 5.19E+164 0.961269 0.998648 Operations and Procedures Diagnostic endocrinology T 379101 1212 377889 5.73E-05 -9.7675 121.094 4.79E-108 6.84E+98 0.935712 0.998648 Operations and Procedures Autonomic cardiovascular testing T 379101 235 378866 0.000114 -9.0797 196.773 3.63E-172 3.58E+163 0.963196 0.998648 Operations and Procedures Other diagnostic imaging of genitourinary system T 379101 209 378892 0.000113 -9.08376 199.395 2.12E-174 6.07E+165 0.963664 0.998648 Operations and Procedures Rehabilitation for musculoskeletal disorders T 379101 364 378737 6.70E-05 -9.61131 196.148 7.27E-172 6.17E+162 0.960919 0.998648 Operations and Procedures Rehabilitation for neurological disorders T 379101 314 378787 7.61E-05 -9.48326 199.192 2.12E-174 2.74E+165 0.962028 0.998648 Operations and Procedures Rehabilitation for other disorders T 379101 724 378377 9.43E-05 -9.26877 118.209 2.25E-105 3.95E+96 0.937502 0.998648 Operations and Procedures Reduction of fracture of other bone of face T 379101 686 378415 0.000102 -9.18744 118.771 8.13E-106 1.29E+97 0.938342 0.998648 Operations and Procedures Fixation of bone of face T 379101 219 378882 0.000117 -9.05392 194.236 5.38E-170 2.54E+161 0.962822 0.998648 Operations and Procedures Fixation of mandible T 379101 258 378843 9.99E-05 -9.21179 194.397 3.35E-170 2.97E+161 0.962205 0.998648 Operations and Procedures Primary decompression operations on cervical spine T 379101 557 378544 4.22E-05 -10.072 199.077 1.47E-174 1.21E+165 0.95965 0.998648 Operations and Procedures Primary decompression operations on lumbar spine T 379101 2461 376640 1.06 0.054543 1.0042 0.148 7.56 0.956684 0.998648 Operations and Procedures Primary excision of cervical intervertebral disc T 379101 805 378296 8.13E-05 -9.41676 120.82 1.16E-107 5.68E+98 0.937876 0.998648 Operations and Procedures Primary excision of lumbar intervertebral disc T 379101 1796 377305 3.73E-05 -10.1958 120.879 4.76E-108 2.93E+98 0.932781 0.998648 Operations and Procedures Stabilisation of spine T 379101 284 378817 8.21E-05 -9.40747 198.659 6.49E-174 1.04E+165 0.96223 0.998648 Operations and Procedures Instrumental correction of deformity of spine T 379101 342 378759 7.02E-05 -9.56406 198.971 3.01E-174 1.64E+165 0.961662 0.998648 Operations and Procedures Denervation of spinal facet joint of vertebra T 379101 675 378426 9.59E-05 -9.25175 120.685 1.79E-107 5.14E+98 0.938894 0.998648 Operations and Procedures Manipulation of spine T 379101 218 378883 0.000116 -9.06228 198.258 2.01E-173 6.68E+164 0.963542 0.998648 Operations and Procedures Other operations on intervertebral disc T 379101 298 378803 8.51E-05 -9.37174 198.238 1.54E-173 4.72E+164 0.962294 0.998648 Operations and Procedures Other operations on spine T 379101 4622 374479 1.18 0.163894 0.712639 0.291 4.76 0.818106 0.998648 Operations and Procedures Levels of spine T 379101 6828 372273 1.17 0.152764 0.583858 0.371 3.66 0.793595 0.998648 Operations and Procedures Complex reconstruction of forefoot T 379101 800 378301 9.65E-05 -9.24595 116.793 3.70E-104 2.52E+95 0.936901 0.998648 Operations and Procedures Complex reconstruction of hindfoot T 379101 342 378759 7.14E-05 -9.547 198.342 1.05E-173 4.85E+164 0.961609 0.998648 Operations and Procedures Total excision of bone T 379101 1188 377913 2.31 0.835344 1.00568 0.321 16.6 0.406187 0.998648 Operations and Procedures Other excision of bone T 379101 3701 375400 1.48 0.389491 0.712642 0.365 5.97 0.584692 0.998648 Operations and Procedures Extirpation of lesion of bone T 379101 466 378635 5.08E-05 -9.88837 199.364 1.01E-174 2.56E+165 0.960441 0.998648 Operations and Procedures Other periarticular division of bone T 379101 263 378838 9.99E-05 -9.21141 196.339 7.45E-172 1.34E+163 0.96258 0.998648 Operations and Procedures Diaphyseal division of bone T 379101 396 378705 7.43E-05 -9.5077 187.449 2.05E-164 2.70E+155 0.959547 0.998648 Operations and Procedures Division of bone of foot T 379101 4767 374334 0.605 -0.503235 1.00621 0.0841 4.34 0.616983 0.998648 Operations and Procedures Other division of bone T 379101 1162 377939 5.94E-05 -9.73176 119.361 1.48E-106 2.38E+97 0.935019 0.998648 Operations and Procedures Bone and intramedullary fixation T 379101 2523 376578 7.12E-05 -9.55028 73.4948 1.96E-67 2.58E+58 0.89661 0.998648 Operations and Procedures Bone and extramedullary fixation T 379101 5789 373312 1.89 0.636048 0.507655 0.698 5.11 0.210237 0.998648 Operations and Procedures Primary open reduction of intra articular fracture of bone T 379101 292 378809 8.71E-05 -9.34831 199.553 1.19E-174 6.35E+165 0.962636 0.998648 Operations and Procedures Closed reduction of fracture of bone and internal fixation T 379101 2838 376263 0.954 -0.047384 1.0039 0.133 6.82 0.962354 0.998648 Operations and Procedures Closed reduction of fracture of bone and external fixation T 379101 391 378710 6.68E-05 -9.61414 198.316 1.03E-173 4.31E+164 0.961335 0.998648 Operations and Procedures Other closed reduction of fracture of bone T 379101 1496 377605 4.97E-05 -9.90907 119.82 5.05E-107 4.89E+97 0.93409 0.998648 Operations and Procedures Other internal fixation of bone T 379101 5999 373102 0.443 -0.813569 1.00362 0.062 3.17 0.417575 0.998648 Operations and Procedures Skeletal traction of bone T 379101 210 378891 0.000122 -9.00921 198.486 1.36E-173 1.10E+165 0.963797 0.998648 Operations and Procedures Other external fixation of bone T 379101 667 378434 9.96E-05 -9.21468 120.908 1.20E-107 8.26E+98 0.93925 0.998648 Operations and Procedures Other autograft of bone T 379101 1078 378023 2.55 0.935412 1.00416 0.356 18.2 0.351576 0.998648 Operations and Procedures Other graft of bone T 379101 696 378405 9.99E-05 -9.21172 120.55 2.43E-107 4.11E+98 0.93909 0.998648 Operations and Procedures Other open operations on bone T 379101 605 378496 0.00011 -9.11468 120.53 2.78E-107 4.35E+98 0.93972 0.998648 Operations and Procedures Diagnostic puncture of bone T 379101 3796 375305 0.698 -0.359662 1.00448 0.0974 5 0.720299 0.998648 Operations and Procedures Total prosthetic replacement of hip joint not using cement T 379101 4094 375007 1.95 0.668645 0.585887 0.619 6.15 0.253765 0.998648 Operations and Procedures Other total prosthetic replacement of hip joint T 379101 1064 378037 6.63E-05 -9.62203 116.884 2.13E-104 2.06E+95 0.934392 0.998648 Operations and Procedures Total prosthetic replacement of knee joint using cement T 379101 7800 371301 0.346 -1.06109 1.00572 0.0482 2.48 0.291399 0.998648 Operations and Procedures Total prosthetic knee joint not using cement T 379101 695 378406 0.000103 -9.17766 117.394 1.22E-104 8.75E+95 0.937686 0.998648 Operations and Procedures Other total prosthetic replacement of knee joint T 379101 844 378257 3.14 1.1453 1.00644 0.437 22.6 0.255132 0.998648 Operations and Procedures Total prosthetic replacement of other joint not using cement T 379101 305 378796 9.27E-05 -9.28658 194.09 5.68E-170 1.51E+161 0.961838 0.998648 Operations and Procedures Other total prosthetic replacement of other joint T 379101 332 378769 8.06E-05 -9.4254 195.796 1.74E-171 3.73E+162 0.961605 0.998648 Operations and Procedures Prosthetic replacement of head of femur using cement T 379101 222 378879 5.16E-05 -9.87152 307.544 8.44E-267 3.16E+257 0.974394 0.998648 Operations and Procedures Other interposition reconstruction of joint T 379101 307 378794 8.82E-05 -9.33627 191.622 6.81E-168 1.14E+159 0.961141 0.998648 Operations and Procedures Other reconstruction of joint T 379101 2374 376727 1.06 0.059833 1.00456 0.148 7.6 0.952505 0.998648 Operations and Procedures Fusion of joint of toe T 379101 3193 375908 0.905 -0.100105 1.00559 0.126 6.49 0.920703 0.998648 Operations and Procedures Other primary fusion of other joint T 379101 1462 377639 1.88 0.631162 1.00447 0.262 13.5 0.529773 0.998648 Operations and Procedures Primary open reduction of traumatic dislocation of joint T 379101 347 378754 7.42E-05 -9.50872 199.443 1.26E-174 4.36E+165 0.961974 0.998648 Operations and Procedures Primary closed reduction of traumatic dislocation of joint T 379101 775 378326 3.59 1.27838 1.00444 0.501 25.7 0.203112 0.998648 Operations and Procedures Secondary reduction of traumatic dislocation of joint T 379101 235 378866 0.000116 -9.05972 198.896 5.78E-174 2.34E+165 0.963669 0.998648 Operations and Procedures Open operations on synovial membrane of joint T 379101 853 378248 7.60E-05 -9.48448 121.007 7.55E-108 7.66E+98 0.937526 0.998648 Operations and Procedures Other open operations on intra articular structure T 379101 1473 377628 4.58E-05 -9.9916 120.567 1.08E-107 1.95E+98 0.933954 0.998648 Operations and Procedures Other reconstruction of ligament T 379101 749 378352 9.09E-05 -9.30543 117.827 4.60E-105 1.80E+96 0.937052 0.998648 Operations and Procedures Other open repair of ligament T 379101 420 378681 5.94E-05 -9.73191 198.798 3.57E-174 9.86E+164 0.960956 0.998648 Operations and Procedures Other operations on ligament T 379101 254 378847 9.40E-05 -9.2727 199.083 3.24E-174 2.73E+165 0.96285 0.998648 Operations and Procedures Stabilising operations on joint T 379101 716 378385 8.85E-05 -9.33291 120.896 1.09E-107 7.17E+98 0.938466 0.998648 Operations and Procedures Release of contracture of joint T 379101 1613 377488 1.68 0.515959 1.00403 0.234 12 0.607332 0.998648 Operations and Procedures Soft tissue operations on joint of toe T 379101 2721 376380 7.96E-05 -9.43885 70.0244 1.97E-64 3.21E+55 0.892775 0.998648 Operations and Procedures Other open operations on joint T 379101 1273 377828 5.26E-05 -9.8528 120.835 7.31E-108 3.78E+98 0.935013 0.998648 Operations and Procedures Therapeutic endoscopic operations on semilunar cartilage T 379101 12492 366609 1.47 0.387607 0.388189 0.688 3.15 0.318037 0.998648 Operations and Procedures Therapeutic endoscopic operations on other articular cartilage T 379101 3095 376006 0.798 -0.225154 1.00388 0.112 5.71 0.822536 0.998648 Operations and Procedures Therapeutic endoscopic operations on other joint structure T 379101 4753 374348 1.63 0.48922 0.583789 0.519 5.12 0.402026 0.998648 Operations and Procedures Therapeutic endoscopic operations on cavity of knee joint T 379101 4112 374989 0.615 -0.48689 1.00366 0.0859 4.39 0.627595 0.998648 Operations and Procedures Therapeutic endoscopic operations on cavity of other joint T 379101 583 378518 0.000113 -9.09175 120.844 1.54E-107 8.24E+98 0.940027 0.998648 Operations and Procedures Diagnostic endoscopic examination of knee joint T 379101 3016 376085 0.873 -0.13546 1.00368 0.122 6.24 0.89264 0.998648 Operations and Procedures Diagnostic endoscopic examination of other joint T 379101 560 378541 4.37E-05 -10.0374 199.027 1.68E-174 1.14E+165 0.959778 0.998648 Operations and Procedures Operations on other articular cartilage T 379101 1114 377987 5.80E-05 -9.75565 120.87 7.53E-108 4.46E+98 0.935671 0.998648 Operations and Procedures Puncture of joint T 379101 10120 368981 0.558 -0.584201 0.712233 0.138 2.25 0.41208 0.998648 Operations and Procedures Other manipulation of joint T 379101 2050 377051 9.22E-05 -9.29206 73.106 5.44E-67 1.56E+58 0.898858 0.998648 Operations and Procedures Other operations on joint T 379101 520 378581 4.78E-05 -9.94908 199.575 6.27E-175 3.64E+165 0.960241 0.998648 Operations and Procedures Hybrid prosthetic replacement of hip joint T 379101 286 378815 0.00011 -9.11909 191.643 8.12E-168 1.48E+159 0.962048 0.998648 Operations and Procedures Replacement of hip joint T 379101 1139 377962 5.87E-05 -9.74344 116.171 7.62E-104 4.52E+94 0.933159 0.998648 Operations and Procedures Continuous Infusion of therapeutic substance T 379101 8393 370708 0.985 -0.015346 0.58433 0.313 3.1 0.979048 0.998648 Operations and Procedures Injection of therapeutic substance T 379101 1288 377813 5.71E-05 -9.77077 119.167 2.09E-106 1.56E+97 0.934653 0.998648 Operations and Procedures Injection of radiocontrast material T 379101 1644 377457 4.15E-05 -10.0892 120.149 2.22E-107 7.78E+97 0.933078 0.998648 Operations and Procedures Other blood transfusion T 379101 4631 374470 1.17 0.154426 0.712759 0.289 4.72 0.828474 0.998648 Operations and Procedures Other intravenous transfusion T 379101 222 378879 0.000113 -9.08951 198.902 5.54E-174 2.30E+165 0.963551 0.998648 Operations and Procedures Other intravenous injection T 379101 5047 374054 3.61E-05 -10.2292 72.9444 2.92E-67 4.46E+57 0.888477 0.998648 Operations and Procedures Subcutaneous injection T 379101 2578 376523 1.05 0.046716 1.00397 0.146 7.5 0.962887 0.998648 Operations and Procedures Other route of administration of therapeutic substance T 379101 241 378860 0.000123 -9.0018 194.461 3.65E-170 4.16E+161 0.963078 0.998648 Operations and Procedures Compensation for renal failure T 379101 703 378398 3.71 1.31098 1.00538 0.517 26.6 0.192246 0.998648 Operations and Procedures Immobilisation using plaster cast T 379101 694 378407 0.000102 -9.19075 120.583 2.32E-107 4.48E+98 0.939245 0.998648 Operations and Procedures Other operations on unspecified organ T 379101 2194 376907 4.36E-05 -10.0404 108.296 2.86E-97 6.65E+87 0.926132 0.998648 Operations and Procedures Radiotherapy delivery T 379101 2124 376977 2.27 0.818235 0.715415 0.558 9.21 0.25274 0.998648 Operations and Procedures Preparation for external beam radiotherapy T 379101 655 378446 9.98E-05 -9.21252 120 7.13E-107 1.40E+98 0.938806 0.998648 Operations and Procedures Procurement of drugs for chemotherapy for neoplasm in Bands 1 5 T 379101 5730 373371 3.06E-05 -10.3939 72.9295 2.55E-67 3.67E+57 0.886669 0.998648 Operations and Procedures Procurement of drugs for chemotherapy for neoplasm in Bands 6 10 T 379101 4078 375023 1.25 0.224469 0.713082 0.309 5.06 0.752923 0.998648 Operations and Procedures Delivery of chemotherapy for neoplasm T 379101 7579 371522 0.693 -0.367178 0.713045 0.171 2.8 0.606592 0.998648 Operations and Procedures Delivery of oral chemotherapy for neoplasm T 379101 560 378541 4.48E-05 -10.014 197.459 3.72E-173 5.39E+163 0.959553 0.998648 Operations and Procedures High cost other cardiovascular drugs T 379101 535 378566 4.77E-05 -9.94992 196.01 6.79E-172 3.36E+162 0.959515 0.998648 Operations and Procedures High cost haematology and nutrition drugs T 379101 606 378495 0.000112 -9.09985 120.331 4.17E-107 2.99E+98 0.939719 0.998648 Operations and Procedures High cost musculoskeletal drugs T 379101 570 378531 4.35E-05 -10.0435 199.133 1.36E-174 1.39E+165 0.959775 0.998648 Operations and Procedures High cost ophthalmology drugs T 379101 346 378755 8.46E-05 -9.37714 190.448 6.53E-167 1.10E+158 0.96073 0.998648 Operations and Procedures High cost immunology drugs T 379101 340 378761 6.98E-05 -9.56956 197.777 3.11E-173 1.57E+164 0.961409 0.998648 Operations and Procedures Placement of prosthesis in organ NOC T 379101 3165 375936 0.82 -0.198485 1.00596 0.114 5.89 0.843587 0.998648 Operations and Procedures Attention to prosthesis in organ NOC T 379101 2929 376172 0.904 -0.100979 1.00396 0.126 6.47 0.919883 0.998648 Operations and Procedures Obliteration of cavity of organ NOC T 379101 637 378464 0.000104 -9.1738 119.619 1.56E-106 6.88E+97 0.938869 0.998648 Operations and Procedures Laser therapy to organ NOC T 379101 2987 376114 1.78 0.57789 0.713251 0.44 7.21 0.417814 0.998648 Operations and Procedures Other destruction of organ NOC T 379101 2176 376925 8.42E-05 -9.38207 73.0689 5.34E-67 1.33E+58 0.897832 0.998648 Operations and Procedures Chemical destruction of lesion of organ NOC T 379101 228 378873 0.000119 -9.03969 192.069 3.82E-168 3.69E+159 0.962462 0.998648 Operations and Procedures Other destruction of lesion of organ NOC T 379101 2552 376549 1.02 0.017224 1.00396 0.142 7.28 0.986312 0.998648 Operations and Procedures Placement of stent in organ NOC T 379101 1320 377781 5.10E-05 -9.88385 117.628 3.81E-105 6.83E+95 0.933036 0.998648 Operations and Procedures Attention to stent in organ NOC T 379101 390 378711 6.23E-05 -9.68349 197.955 1.96E-173 1.98E+164 0.960985 0.998648 Operations and Procedures Connection of organ NOC T 379101 354 378747 7.06E-05 -9.55861 197.464 5.81E-173 8.58E+163 0.961392 0.998648 Operations and Procedures Release of organ NOC T 379101 896 378205 3.07 1.12086 1.00441 0.428 22 0.264451 0.998648 Operations and Procedures Biopsy of organ NOC T 379101 7160 371941 0.739 -0.303132 0.713051 0.183 2.99 0.67075 0.998648 Operations and Procedures Cytology of organ NOC T 379101 2554 376547 2.21 0.791353 0.713042 0.545 8.93 0.267074 0.998648 Operations and Procedures Drainage of organ NOC T 379101 2627 376474 6.77E-05 -9.60047 73.4522 2.03E-67 2.26E+58 0.89601 0.998648 Operations and Procedures Other repair of organ NOC T 379101 893 378208 2.95 1.08024 1.00433 0.411 21.1 0.282115 0.998648 Operations and Procedures Graft to organ NOC T 379101 624 378477 0.000107 -9.1403 121.005 1.07E-107 1.08E+99 0.939788 0.998648 Operations and Procedures Re exploration of organ NOC T 379101 217 378884 0.000108 -9.13138 199.089 3.68E-174 3.18E+165 0.963417 0.998648 Operations and Procedures Puncture of organ NOC T 379101 315 378786 8.26E-05 -9.40094 198.648 6.68E-174 1.02E+165 0.962254 0.998648 Operations and Procedures Injection of therapeutic substance into organ NOC T 379101 608 378493 0.000118 -9.04634 120.707 2.11E-107 6.59E+98 0.940259 0.998648 Operations and Procedures Dilation of organ NOC T 379101 512 378589 4.77E-05 -9.95115 197.954 1.50E-173 1.51E+164 0.959907 0.998648 Operations and Procedures Examination of organ NOC T 379101 581 378520 4.25E-05 -10.0668 198.743 2.85E-174 6.33E+164 0.959603 0.998648 Operations and Procedures Open approach to contents of cranium T 379101 800 378301 8.03E-05 -9.42931 120.995 8.16E-108 7.91E+98 0.937882 0.998648 Operations and Procedures Burrhole approach to contents of cranium T 379101 411 378690 5.98E-05 -9.72486 197.552 4.14E-173 8.63E+163 0.960739 0.998648 Operations and Procedures Approach to spine through back T 379101 309 378792 7.37E-05 -9.51558 198.285 1.21E-173 4.48E+164 0.961725 0.998648 Operations and Procedures Approach through thoracic cavity T 379101 602 378499 4.07E-05 -10.1101 195.137 3.20E-171 5.17E+161 0.95868 0.998648 Operations and Procedures Approach through abdominal cavity T 379101 6488 372613 1.75 0.557048 0.508635 0.644 4.73 0.273437 0.998648 Operations and Procedures Opening into gastrointestinal tract T 379101 207 378894 0.000126 -8.97718 196.854 3.43E-172 4.64E+163 0.963626 0.998648 Operations and Procedures Approach to organ through other opening T 379101 1441 377660 4.69E-05 -9.96745 120.735 7.93E-108 2.77E+98 0.934204 0.998648 Operations and Procedures Approach to organ under image control T 379101 45067 334034 1.19 0.173253 0.244236 0.737 1.92 0.478098 0.998648 Operations and Procedures Harvest of skin for graft T 379101 2280 376821 1.13 0.125208 1.00481 0.158 8.12 0.900833 0.998648 Operations and Procedures Harvest of flap of skin and fascia T 379101 546 378555 4.57E-05 -9.99248 199.548 6.33E-175 3.30E+165 0.960062 0.998648 Operations and Procedures Harvest of tendon T 379101 532 378569 4.66E-05 -9.97304 198.152 9.96E-174 2.18E+164 0.959859 0.998648 Operations and Procedures Harvest of bone T 379101 1453 377648 1.84 0.611691 1.00393 0.258 13.2 0.542327 0.998648 Operations and Procedures Harvest of other tissue T 379101 784 378317 8.47E-05 -9.37604 120.914 1.01E-107 7.11E+98 0.938191 0.998648 Operations and Procedures Early operations NOC T 379101 2989 376112 6.09E-05 -9.70631 72.6669 8.50E-67 4.36E+57 0.89374 0.998648 Operations and Procedures Late operations NOC T 379101 5407 373694 3.29E-05 -10.3231 73.4057 1.08E-67 1.00E+58 0.888161 0.998648 Operations and Procedures Facilitating operations NOC T 379101 2533 376568 7.22E-05 -9.53539 69.9011 2.28E-64 2.29E+55 0.891495 0.998648 Operations and Procedures Minimal access to thoracic cavity T 379101 726 378375 3.59 1.2781 1.00532 0.5 25.8 0.203609 0.998648 Operations and Procedures Minimal access to abdominal cavity T 379101 14863 364238 0.524 -0.646211 0.58365 0.167 1.65 0.268213 0.998648 Operations and Procedures Arteriotomy approach to organ under image control T 379101 426 378675 5.80E-05 -9.75448 191.401 6.92E-168 4.87E+158 0.959354 0.998648 Operations and Procedures Approach to organ through artery T 379101 284 378817 7.22E-05 -9.53586 186.968 5.11E-164 1.02E+155 0.959324 0.998648 Operations and Procedures General anaesthetic T 379101 13536 365565 0.885 -0.122038 0.438109 0.375 2.09 0.780585 0.998648 Operations and Procedures Spinal anaesthetic T 379101 6624 372477 2.81E-05 -10.4801 70.6346 2.10E-65 3.75E+55 0.88205 0.998648 Operations and Procedures Local anaesthetic T 379101 23563 355538 1.28 0.243493 0.306893 0.699 2.33 0.427538 0.998648 Operations and Procedures Other anaesthetic T 379101 5945 373156 1.62 0.480927 0.5133 0.591 4.42 0.348794 0.998648 Operations and Procedures Other non operations T 379101 2978 376123 7.94E-05 -9.4405 68.165 7.53E-63 8.38E+53 0.889849 0.998648 Operations and Procedures External beam radiotherapy T 379101 1376 377725 4.25E-05 -10.0669 117.542 3.75E-105 4.81E+95 0.931748 0.998648 Operations and Procedures Radiopharmaceutical imaging T 379101 249 378852 0.000107 -9.1465 198.572 1.00E-173 1.14E+165 0.963261 0.998648 Operations and Procedures Gestational age T 379101 395 378706 0.000107 -9.14637 258.733 6.16E-225 1.84E+216 0.9718 0.998648 NA Myocardial infarction T 379101 13488 365613 0.563 -0.574524 0.589543 0.177 1.79 0.329797 0.998648 NA STEMI T 379101 3811 375290 5.05E-05 -9.89353 69.7651 2.08E-64 1.23E+55 0.887228 0.998648 NA NSTEMI T 379101 4419 374682 0.586 -0.533583 1.00625 0.0816 4.22 0.595925 0.998648 NA Stroke T 379101 8703 370398 1.57 0.447902 0.458561 0.637 3.84 0.32869 0.998648 NA Ischaemic stroke T 379101 3655 375446 1.47 0.386713 0.715175 0.362 5.98 0.588697 0.998648 NA Intracerebral haemorrhage T 379101 792 378309 8.60E-05 -9.36083 118.797 6.50E-106 1.14E+97 0.937194 0.998648 Mental health Ever depressed for a whole week T 124064 66758 57306 0.784 -0.24298 0.255204 0.476 1.29 0.341047 0.998648 Mental health Ever manic hyper for 2 days T 123498 7031 116467 0.267 -1.3204 1.00923 0.0369 1.93 0.190765 0.998648 Mental health Ever highly irritable argumentative for 2 days T 123759 22263 101496 0.88 -0.127611 0.347937 0.445 1.74 0.713794 0.998648 Cardiovascular Leg pain on walking T 125416 27294 98122 0.841 -0.173318 0.321745 0.448 1.58 0.590107 0.998648 Eye Ever had eye surgery T 84673 6217 78456 0.372 -0.989964 1.01324 0.051 2.71 0.328555 0.998648 Eye Current eye infection T 85179 898 84281 4.47E-05 -10.0155 148.672 1.25E-131 1.59E+122 0.94629 0.998648 Eye Diabetes related eye disease T 124376 2369 122007 2.59E-05 -10.563 118.957 1.43E-106 4.69E+96 0.929243 0.998648 Eye Glaucoma T 124376 5306 119070 1.44 0.365644 0.60075 0.444 4.68 0.542759 0.998648 Eye Cataract T 124376 11723 112653 0.654 -0.425036 0.603522 0.2 2.13 0.481271 0.998648 Eye Macular degeneration T 124376 2870 121506 6.42E-05 -9.65336 71.6922 6.05E-66 6.81E+56 0.892889 0.998648 Eye Other serious eye condition T 124376 6929 117447 1.01 0.013166 0.595313 0.315 3.25 0.982356 0.998648 ENT Mouth ulcers T 377646 38476 339170 1.01 0.011366 0.27329 0.592 1.73 0.966825 0.998648 ENT Painful gums T 377646 10716 366930 0.495 -0.703941 0.711933 0.123 2 0.322774 0.998648 ENT Bleeding gums T 377646 49304 328342 0.962 -0.038265 0.253722 0.585 1.58 0.880121 0.998648 ENT Loose teeth T 377646 15091 362555 0.521 -0.651787 0.583968 0.166 1.64 0.264364 0.998648 ENT Toothache T 377646 15330 362316 1.38 0.319437 0.364653 0.673 2.81 0.38103 0.998648 ENT Dentures T 377646 63135 314511 0.746 -0.292616 0.261766 0.447 1.25 0.263629 0.998648 Cardiovascular Blood pressure medication T 376222 77608 298614 0.916 -0.087986 0.223369 0.591 1.42 0.693652 0.998648 Metabolic Insulin T 376222 3934 372288 1.36 0.30817 0.713083 0.336 5.51 0.665621 0.998648 Medication Aspirin T 374768 52613 322155 0.81 -0.211156 0.265545 0.481 1.36 0.426508 0.998648 Medication Ibuprofen e g Nurofen T 374768 55904 318864 0.762 -0.271734 0.260626 0.457 1.27 0.297124 0.998648 Medication Paracetamol T 374768 81842 292926 1.2 0.180352 0.195953 0.816 1.76 0.35737 0.998648 Medication Ranitidine e g Zantac T 374768 7205 367563 0.377 -0.974724 1.00369 0.0528 2.7 0.331481 0.998648 Medication Omeprazole e g Zanprol T 374768 22414 352354 1.38 0.319202 0.315961 0.741 2.56 0.312372 0.998648 Medication Laxatives e g Dulcolax Senokot T 374768 10818 363950 1.05 0.050506 0.509566 0.387 2.86 0.921047 0.998648 Medication Vitamin A T 377036 7193 369843 0.363 -1.01391 1.00363 0.0507 2.59 0.312376 0.998648 Medication Vitamin C T 377036 32744 344292 0.872 -0.136743 0.313915 0.471 1.61 0.663122 0.998648 Medication Vitamin D T 377036 14603 362433 0.539 -0.617751 0.584856 0.171 1.7 0.290856 0.998648 Medication Vitamin E T 377036 11056 365980 0.716 -0.334382 0.584023 0.228 2.25 0.56695 0.998648 Medication Folic acid or Folate Vit B9 T 377036 8174 368862 0.327 -1.11788 1.0038 0.0457 2.34 0.26543 0.998648 Medication Multivitamins minerals T 377036 81736 295300 1.09 0.082511 0.199003 0.735 1.6 0.67842 0.998648 Neurosciences Headache T 378231 81591 296640 1.1 0.092408 0.201149 0.739 1.63 0.645948 0.998648 Neurosciences Facial pain T 378231 12842 365389 0.422 -0.863658 0.712016 0.104 1.7 0.225139 0.998648 Neurosciences Neck or shoulder pain T 378231 92289 285942 0.874 -0.135117 0.20296 0.587 1.3 0.505582 0.998648 Neurosciences Stomach or abdominal pain T 378231 37960 340271 0.69 -0.371428 0.328525 0.362 1.31 0.258227 0.998648 Neurosciences Knee pain T 378231 86052 292179 0.762 -0.271308 0.217145 0.498 1.17 0.211507 0.998648 Neurosciences Pain all over the body T 378231 5847 372384 0.469 -0.757062 1.00365 0.0656 3.35 0.450663 0.998648 Medication Fish oil including cod liver oil T 377850 119641 258209 1.03 0.024893 0.181749 0.718 1.46 0.891062 0.998648 Medication Calcium T 377850 25583 352267 1.09 0.08213 0.334131 0.564 2.09 0.805835 0.998648 Medication Zinc T 377850 15460 362390 0.499 -0.695071 0.583819 0.159 1.57 0.233827 0.998648 Medication Selenium T 377850 9070 368780 1.17 0.154095 0.507733 0.431 3.16 0.761512 0.998648 Cardiovascular Hypertension (HES and self-reported) T 379101 98025 281076 1.03 0.033992 0.194949 0.706 1.52 0.861578 0.998648 Cardiovascular Heartcardiac problem (HES and self-reported) T 379101 25675 353426 0.692 -0.367631 0.39514 0.319 1.5 0.352173 0.998648 Cardiovascular Peripheral vascular disease (HES and self-reported) T 379101 1859 377242 3.71E-05 -10.203 118.904 2.27E-106 6.05E+96 0.931619 0.998648 Cardiovascular Venous thromboembolic disease (HES and self-reported) T 379101 3983 375118 1.32 0.279195 0.713007 0.327 5.35 0.695373 0.998648 Cardiovascular Essential hypertension (HES and self-reported) T 379101 71076 308025 0.915 -0.088761 0.227943 0.585 1.43 0.696982 0.998648 Cardiovascular Gestational hypertensionpreeclampsia (HES and self-reported) T 379101 2534 376567 3.74E-05 -10.1929 107.609 9.43E-97 1.49E+87 0.924536 0.998648 Cardiovascular Heart attackmyocardial infarction (HES and self-reported) T 379101 12068 367033 0.632 -0.458306 0.589614 0.199 2.01 0.436983 0.998648 Cardiovascular Heart failurepulmonary odema (HES and self-reported) T 379101 5221 373880 3.68E-05 -10.2089 70.1286 7.44E-65 1.82E+55 0.884257 0.998648 Cardiovascular Heart arrhythmia (HES and self-reported) T 379101 21190 357911 1.26 0.234766 0.333938 0.657 2.43 0.482041 0.998648 Cardiovascular Heart valve problemheart murmur (HES and self-reported) T 379101 7532 371569 1.8 0.588838 0.457061 0.736 4.41 0.197637 0.998648 Cardiovascular Cardiomyopathy (HES and self-reported) T 379101 1272 377829 5.14E-05 -9.87492 119.07 2.27E-106 1.16E+97 0.933904 0.998648 Cardiovascular Pericardial problem (HES and self-reported) T 379101 1268 377833 2.06 0.721236 1.00492 0.287 14.7 0.472938 0.998648 Cardiovascular Stroke (HES and self-reported) T 379101 8571 370530 1.58 0.460568 0.458677 0.645 3.89 0.31532 0.998648 Cardiovascular Transient ischaemic attack tia (HES and self-reported) T 379101 3570 375531 0.759 -0.275716 1.00566 0.106 5.45 0.783958 0.998648 Cardiovascular Subdural haemorrhagehaematoma (HES and self-reported) T 379101 380 378721 6.67E-05 -9.61519 194.83 9.58E-171 4.64E+161 0.960639 0.998648 Cardiovascular Arterial embolism (HES and self-reported) T 379101 762 378339 9.70E-05 -9.24103 115.869 2.28E-103 4.13E+94 0.936433 0.998648 Cardiovascular Deep venous thrombosis dvt (HES and self-reported) T 379101 8917 370184 1.52 0.417009 0.456424 0.62 3.71 0.360904 0.998648 Respiratory Interstitial lung disease (HES and self-reported) T 379101 1083 378018 6.66E-05 -9.61722 116.837 2.34E-104 1.89E+95 0.934398 0.998648 Respiratory Asbestosis (HES and self-reported) T 379101 271 378830 4.11E-05 -10.0993 286.554 4.95E-249 3.42E+239 0.971885 0.998648 Respiratory Pulmonary fibrosis (HES and self-reported) T 379101 789 378312 9.40E-05 -9.27219 116.115 1.36E-103 6.49E+94 0.936354 0.998648 ENT Sleep apnoea (HES and self-reported) T 379101 4559 374542 0.554 -0.591111 1.00432 0.0773 3.96 0.556149 0.998648 Digestive system Oesophageal disorder (HES and self-reported) T 379101 9080 370021 1.19 0.171365 0.509036 0.438 3.22 0.736384 0.998648 Digestive system Stomach disorder (HES and self-reported) T 379101 7348 371753 1.53 0.426665 0.508251 0.566 4.15 0.401202 0.998648 Digestive system Other abdominal problem (HES and self-reported) T 379101 39890 339211 1.09 0.089126 0.266727 0.648 1.84 0.738268 0.998648 Digestive system Gastrooesophageal reflux gord gastric reflux (HES and self-reported) T 379101 32601 346500 0.91 -0.094823 0.314802 0.491 1.69 0.763251 0.998648 Digestive system Oesophagitisbarretts oesophagus (HES and self-reported) T 379101 10521 368580 1.02 0.021674 0.508528 0.377 2.77 0.966004 0.998648 Digestive system Oesophageal stricture (HES and self-reported) T 379101 1781 377320 3.84E-05 -10.1665 118.796 2.91E-106 5.08E+96 0.9318 0.998648 Digestive system Oesophageal varicies (HES and self-reported) T 379101 501 378600 5.05E-05 -9.89441 195.924 8.49E-172 3.00E+162 0.959723 0.998648 Digestive system Gastricstomach ulcers (HES and self-reported) T 379101 6128 372973 0.898 -0.107482 0.713436 0.222 3.64 0.880249 0.998648 Digestive system Gastritisgastric erosions (HES and self-reported) T 379101 21127 357974 1.06 0.06186 0.365356 0.52 2.18 0.865549 0.998648 Digestive system Irritable bowel syndrome (HES and self-reported) T 379101 12379 366722 0.665 -0.408564 0.584598 0.211 2.09 0.484626 0.998648 Digestive system Hepatitis (HES and self-reported) T 379101 1662 377439 4.08E-05 -10.107 120.708 7.28E-108 2.29E+98 0.93327 0.998648 Digestive system Infectiveviral hepatitis (HES and self-reported) T 379101 1240 377861 5.37E-05 -9.83251 120.723 9.30E-108 3.10E+98 0.935087 0.998648 Digestive system Noninfective hepatitis (HES and self-reported) T 379101 1195 377906 5.72E-05 -9.76918 120.754 9.32E-108 3.51E+98 0.935521 0.998648 Digestive system Bile duct obstructionascending cholangitis (HES and self-reported) T 379101 936 378165 7.12E-05 -9.54959 120.118 4.04E-107 1.26E+98 0.936633 0.998648 Digestive system Cholelithiasisgall stones (HES and self-reported) T 379101 16555 362546 1.56 0.446478 0.346968 0.792 3.08 0.198165 0.998648 Digestive system Cholecystitis (HES and self-reported) T 379101 2791 376310 6.76E-05 -9.60143 72.9683 5.23E-67 8.75E+57 0.895314 0.998648 Digestive system Peritonitis (HES and self-reported) T 379101 1989 377112 2.7 0.991897 0.712938 0.667 10.9 0.16414 0.998648 Digestive system Gastrointestinal bleeding (HES and self-reported) T 379101 8293 370808 1.64 0.49299 0.456031 0.67 4 0.279677 0.998648 Genitourinary Renalkidney failure (HES and self-reported) T 379101 8356 370745 0.958 -0.042568 0.586798 0.303 3.03 0.94217 0.998648 Genitourinary Renal failure requiring dialysis (HES and self-reported) T 379101 660 378441 0.000101 -9.19719 120.001 7.22E-107 1.42E+98 0.938908 0.998648 Genitourinary Urinary tract infectionkidney infection (HES and self-reported) T 379101 12655 366446 1.09 0.085028 0.456433 0.445 2.66 0.85222 0.998648 Genitourinary Kidney stoneureter stonebladder stone (HES and self-reported) T 379101 6694 372407 2.62E-05 -10.5503 72.3144 7.29E-67 9.40E+56 0.884004 0.998648 Genitourinary Ureteric obstructionhydronephrosis (HES and self-reported) T 379101 2626 376475 0.989 -0.010589 1.00429 0.138 7.08 0.991587 0.998648 Genitourinary Bladder problem not cancer (HES and self-reported) T 379101 10748 368353 1.23 0.208566 0.457707 0.502 3.02 0.648623 0.998648 Genitourinary Urinary frequency incontinence (HES and self-reported) T 379101 11734 367367 0.953 -0.048216 0.508625 0.352 2.58 0.924476 0.998648 Genitourinary Scrotal problem not cancer (HES and self-reported) T 379101 1382 377719 4.83E-08 -16.8457 3646.67 0 Inf 0.996314 0.998648 Genitourinary Testicular problems not cancer (HES and self-reported) T 379101 1283 377818 1.9 0.640398 1.00749 0.263 13.7 0.525012 0.998648 Metabolic Diabetes (HES and self-reported) T 379101 15907 363194 0.482 -0.729971 0.585752 0.153 1.52 0.212687 0.998648 Metabolic Gestational diabetes (HES and self-reported) T 379101 363 378738 8.20E-05 -9.40836 185.127 2.14E-162 3.14E+153 0.959468 0.998648 Metabolic Type 1 diabetes (HES and self-reported) T 379101 2663 376438 0.978 -0.022031 1.00407 0.137 7 0.982494 0.998648 Metabolic Hyperthyroidismthyrotoxicosis (HES and self-reported) T 379101 4020 375081 0.693 -0.366494 1.00496 0.0967 4.97 0.715348 0.998648 Metabolic Hypothyroidismmyxoedema (HES and self-reported) T 379101 22541 356560 0.734 -0.309824 0.421698 0.321 1.68 0.462519 0.998648 Metabolic Thyroid radioablation therapy (HES and self-reported) T 379101 2506 376595 1.98 0.685061 0.715262 0.488 8.06 0.338175 0.998648 Metabolic Parathyroid gland problem not cancer (HES and self-reported) T 379101 274 378827 9.41E-05 -9.27164 196.535 4.78E-172 1.85E+163 0.962373 0.998648 Metabolic Parathyroid hyperplasiaadenoma (HES and self-reported) T 379101 419 378682 6.66E-05 -9.61743 193.251 2.11E-169 2.10E+160 0.960308 0.998648 Metabolic Disorder of adrenal gland (HES and self-reported) T 379101 470 378631 5.29E-05 -9.84678 199.107 1.74E-174 1.61E+165 0.960557 0.998648 Metabolic Adrenocortical insufficiencyaddisons disease (HES and self-reported) T 379101 349 378752 7.00E-05 -9.56721 198.908 3.40E-174 1.44E+165 0.961638 0.998648 Metabolic Disorder or pituitary gland (HES and self-reported) T 379101 409 378692 6.21E-05 -9.68683 199.281 1.45E-174 2.66E+165 0.961231 0.998648 Metabolic Pituitary adenomatumour (HES and self-reported) T 379101 466 378635 5.34E-05 -9.83699 199.359 1.07E-174 2.66E+165 0.960646 0.998648 Eye Eyeeyelid problem (HES and self-reported) T 379101 17843 361258 0.897 -0.1092 0.418214 0.395 2.04 0.794007 0.998648 Neurosciences Psychologicalpsychiatric prob (HES and self-reported) T 379101 2225 376876 8.17E-05 -9.41305 73.421 2.60E-67 2.57E+58 0.897986 0.998648 Neurosciences Infection of nervous system (HES and self-reported) T 379101 529 378572 4.55E-05 -9.99841 199.567 6.07E-175 3.41E+165 0.960042 0.998648 Neurosciences Encephalitis (HES and self-reported) T 379101 415 378686 5.77E-05 -9.75995 199.731 5.58E-175 5.97E+165 0.961027 0.998648 Neurosciences Meningitis (HES and self-reported) T 379101 1714 377387 3.73E-05 -10.1954 121.105 3.06E-108 4.56E+98 0.932908 0.998648 Neurosciences Cranial nerve problempalsy (HES and self-reported) T 379101 1916 377185 9.46E-05 -9.26606 73.1864 4.77E-67 1.88E+58 0.89925 0.998648 Neurosciences Bells palsyfacial nerve palsy (HES and self-reported) T 379101 922 378179 7.13E-05 -9.54886 121.025 6.83E-108 7.44E+98 0.937112 0.998648 Neurosciences Spinal cord disorder (HES and self-reported) T 379101 1886 377215 9.52E-05 -9.25939 73.3121 3.75E-67 2.42E+58 0.899494 0.998648 Neurosciences Paraplegia (HES and self-reported) T 379101 312 378789 7.77E-05 -9.46272 197.777 3.46E-173 1.74E+164 0.961839 0.998648 Neurosciences Peripheral neuropathy (HES and self-reported) T 379101 2013 377088 1.31 0.269375 1.00445 0.183 9.38 0.788559 0.998648 Neurosciences Acute infective polyneuritisguillainbarre syndro (HES and self-reported) T 379101 290 378811 8.54E-05 -9.36848 198.623 7.24E-174 1.01E+165 0.96238 0.998648 Neurosciences Trapped nervecompressed nerve (HES and self-reported) T 379101 15824 363277 0.497 -0.700086 0.583936 0.158 1.56 0.230563 0.998648 Neurosciences Chronicdegenerative neurological problem (HES and self-reported) T 379101 4087 375014 2 0.692841 0.584602 0.636 6.29 0.235958 0.998648 Neurosciences Motor neurone disease (HES and self-reported) T 379101 231 378870 0.000106 -9.15291 196.013 1.50E-171 7.49E+162 0.962756 0.998648 Neurosciences Multiple sclerosis (HES and self-reported) T 379101 1635 377466 1.65 0.503592 1.00447 0.231 11.9 0.616124 0.998648 Neurosciences Dementiaalzheimerscognitive impairment (HES and self-reported) T 379101 906 378195 3.04 1.11099 1.00908 0.42 22 0.270898 0.998648 Neurosciences Epilepsy (HES and self-reported) T 379101 4619 374482 1.15 0.143389 0.712335 0.286 4.66 0.840468 0.998648 Neurosciences Migraine (HES and self-reported) T 379101 12905 366196 1.04 0.042475 0.457548 0.426 2.56 0.926037 0.998648 Eye Eye infection (HES and self-reported) T 379101 2800 376301 1.89 0.638915 0.712439 0.469 7.65 0.369826 0.998648 Eye Retinal problem (HES and self-reported) T 379101 7219 371882 1.08 0.072375 0.585553 0.341 3.39 0.901632 0.998648 Eye Diabetic eye disease (HES and self-reported) T 379101 1737 377364 3.87E-05 -10.1599 118.892 2.42E-106 6.17E+96 0.9319 0.998648 Eye Glaucoma (HES and self-reported) T 379101 6262 372839 1.27 0.24001 0.586414 0.403 4.01 0.68233 0.998648 Eye Cataract (HES and self-reported) T 379101 20791 358310 1.2 0.184635 0.352693 0.603 2.4 0.600626 0.998648 Eye Eye trauma (HES and self-reported) T 379101 816 378285 8.22E-05 -9.4067 119.373 2.01E-106 3.37E+97 0.937191 0.998648 Eye Retinal detachment (HES and self-reported) T 379101 3632 375469 0.678 -0.388782 1.00458 0.0946 4.86 0.698748 0.998648 Mental health Depression (HES and self-reported) T 379101 27882 351219 0.873 -0.135379 0.345025 0.444 1.72 0.694781 0.998648 Mental health Anxietypanic attacks (HES and self-reported) T 379101 10392 368709 0.79 -0.235347 0.583784 0.252 2.48 0.686845 0.998648 Mental health Nervous breakdown (HES and self-reported) T 379101 629 378472 0.00011 -9.11279 120.901 1.35E-107 9.02E+98 0.939917 0.998648 Mental health Schizophrenia (HES and self-reported) T 379101 686 378415 9.91E-05 -9.21943 119.614 1.51E-106 6.51E+97 0.938563 0.998648 Mental health Deliberate selfharmsuicide attempt (HES and self-reported) T 379101 2635 376466 1.07 0.070055 1.00454 0.15 7.68 0.944402 0.998648 Mental health Maniabipolar disordermanic depression (HES and self-reported) T 379101 1595 377506 4.21E-05 -10.0755 121.04 3.92E-108 4.52E+98 0.93366 0.998648 Musculoskeletal Bone disorder (HES and self-reported) T 379101 5041 374060 1.1 0.094457 0.712566 0.272 4.44 0.894542 0.998648 Musculoskeletal Back problem (HES and self-reported) T 379101 11524 367577 0.927 -0.075914 0.507379 0.343 2.51 0.881065 0.998648 Musculoskeletal Joint disorder (HES and self-reported) T 379101 27274 351827 1.17 0.159322 0.30175 0.649 2.12 0.597503 0.998648 Musculoskeletal Musclesoft tissue problem (HES and self-reported) T 379101 32458 346643 1.27 0.241318 0.273429 0.745 2.18 0.377474 0.998648 Musculoskeletal Osteomyelitis (HES and self-reported) T 379101 1062 378039 6.31E-05 -9.67033 120.238 2.83E-107 1.41E+98 0.935898 0.998648 Musculoskeletal Pagets disease (HES and self-reported) T 379101 272 378829 9.44E-05 -9.26828 197.317 1.04E-172 8.60E+163 0.962536 0.998648 Musculoskeletal Spine arthritisspondylitis (HES and self-reported) T 379101 10404 368697 0.538 -0.620245 0.713146 0.133 2.18 0.384447 0.998648 Musculoskeletal Prolapsed discslipped disc (HES and self-reported) T 379101 8220 370881 0.969 -0.031826 0.583617 0.309 3.04 0.956511 0.998648 Musculoskeletal Ankylosing spondylitis (HES and self-reported) T 379101 1308 377793 5.12E-05 -9.87941 120.325 1.94E-107 1.36E+98 0.934562 0.998648 Musculoskeletal Myositismyopathy (HES and self-reported) T 379101 338 378763 7.26E-05 -9.53044 199.339 1.51E-174 3.48E+165 0.961867 0.998648 Haematology Low plateletsplatelet disorder (HES and self-reported) T 379101 1618 377483 4.18E-05 -10.0835 120.566 9.84E-108 1.77E+98 0.933347 0.998648 Haematology Iron deficiency anaemia (HES and self-reported) T 379101 8597 370504 1.62 0.479385 0.455903 0.661 3.95 0.293026 0.998648 Haematology Pernicious anaemia (HES and self-reported) T 379101 1499 377602 5.06E-05 -9.89228 119.144 1.93E-106 1.32E+97 0.933829 0.998648 Haematology Aplastic anaemia (HES and self-reported) T 379101 429 378672 6.01E-05 -9.71898 196.316 4.69E-172 7.70E+162 0.960515 0.998648 Gynaecology and Obstetrics Gynaecological disorder not c (HES and self-reported) T 379101 16832 362269 1.03 0.027452 0.427006 0.445 2.37 0.94874 0.998648 Gynaecology and Obstetrics Ovarian cyst or cysts (HES and self-reported) T 379101 6134 372967 3.41E-08 -17.194 2203.33 0 Inf 0.993774 0.998648 Gynaecology and Obstetrics Polycystic ovariespolycystic ovarian syndrome (HES and self-reported) T 379101 580 378521 6.44E-08 -16.558 5715.8 0 Inf 0.997689 0.998648 Gynaecology and Obstetrics Uterine fibroids (HES and self-reported) T 379101 13674 365427 5.99E-06 -12.0252 109.115 7.89E-99 4.55E+87 0.912245 0.998648 Gynaecology and Obstetrics Uterine polyps (HES and self-reported) T 379101 8016 371085 1.43 0.358289 0.515108 0.521 3.93 0.486704 0.998648 Gynaecology and Obstetrics Breast disease not cancer (HES and self-reported) T 379101 3704 375397 0.795 -0.229754 1.00636 0.111 5.71 0.819412 0.998648 Gynaecology and Obstetrics Fibrocystic disease (HES and self-reported) T 379101 1743 377358 4.99E-05 -9.90514 111.372 7.88E-100 3.16E+90 0.929132 0.998648 Gynaecology and Obstetrics Breast cysts (HES and self-reported) T 379101 1673 377428 5.38E-05 -9.82981 110.975 1.85E-99 1.57E+90 0.929419 0.998648 Immuno-inflammation Sarcoidosis (HES and self-reported) T 379101 930 378171 6.70E-05 -9.61079 120.997 6.78E-108 6.62E+98 0.93669 0.998648 Musculoskeletal Vasculitis (HES and self-reported) T 379101 1756 377345 1.56 0.442687 1.00576 0.217 11.2 0.659828 0.998648 Immuno-inflammation Connective tissue disorder (HES and self-reported) T 379101 2304 376797 1.2 0.185095 1.00527 0.168 8.63 0.853915 0.998648 Immuno-inflammation Allergyhypersensitivityanaph (HES and self-reported) T 379101 3101 376000 0.902 -0.10319 1.00396 0.126 6.45 0.918135 0.998648 Musculoskeletal Giant celltemporal arteritis (HES and self-reported) T 379101 395 378706 7.48E-05 -9.50122 188.67 1.88E-165 2.97E+156 0.959836 0.998648 Musculoskeletal Polymyalgia rheumatica (HES and self-reported) T 379101 1540 377561 4.92E-05 -9.92014 114.771 9.92E-103 2.44E+93 0.931121 0.998648 Musculoskeletal Systemic lupus erythematosissle (HES and self-reported) T 379101 547 378554 5.51E-05 -9.806 192.993 2.90E-169 1.05E+160 0.959477 0.998648 Musculoskeletal Sjogrens syndromesicca syndrome (HES and self-reported) T 379101 614 378487 5.01E-05 -9.90225 189.163 4.79E-166 5.23E+156 0.958252 0.998648 Musculoskeletal Sclerodermasystemic sclerosis (HES and self-reported) T 379101 201 378900 5.02E-05 -9.90029 318.111 8.29E-276 3.03E+266 0.975172 0.998648 Immuno-inflammation Allergy or anaphylactic reaction to drug (HES and self-reported) T 379101 4200 374901 4.39E-05 -10.0338 73.2011 2.15E-67 8.96E+57 0.890974 0.998648 Immuno-inflammation Hayfeverallergic rhinitis (HES and self-reported) T 379101 22257 356844 1.27 0.24143 0.31463 0.687 2.36 0.442875 0.998648 Neurosciences Other demyelinating disease not multiple sclerosi (HES and self-reported) T 379101 1324 377777 5.11E-05 -9.88262 120.269 2.15E-107 1.21E+98 0.934511 0.998648 Digestive system Peptic ulcer (HES and self-reported) T 379101 770 378331 3.61 1.28245 1.00625 0.502 25.9 0.202495 0.998648 Gynaecology and Obstetrics Endometriosis (HES and self-reported) T 379101 5960 373141 0.484 -0.724908 1.00833 0.0671 3.5 0.472189 0.998648 Gynaecology and Obstetrics Female infertility (HES and self-reported) T 379101 1328 377773 7.90E-08 -16.354 3480.95 0 Inf 0.996251 0.998648 Genitourinary Other renalkidney problem (HES and self-reported) T 379101 5423 373678 3.26E-05 -10.3324 72.9979 2.37E-67 4.46E+57 0.88744 0.998648 Musculoskeletal Muscle or soft tissue injuries (HES and self-reported) T 379101 9386 369715 0.561 -0.577867 0.71193 0.139 2.26 0.416969 0.998648 Musculoskeletal Burns (HES and self-reported) T 379101 765 378336 3.4 1.22441 1.00478 0.475 24.4 0.223003 0.998648 Other Other substance abusedependency (HES and self-reported) T 379101 10328 368773 0.786 -0.240826 0.584511 0.25 2.47 0.68033 0.998648 Respiratory Bronchitis (HES and self-reported) T 379101 3358 375743 1.6 0.468215 0.712538 0.395 6.45 0.51111 0.998648 ENT Throat or larynx disorder (HES and self-reported) T 379101 3484 375617 5.29E-05 -9.8474 73.4089 1.72E-67 1.62E+58 0.893288 0.998648 ENT Earvestibular disorder (HES and self-reported) T 379101 12078 367023 0.884 -0.122956 0.50765 0.327 2.39 0.80862 0.998648 ENT Chronic sinusitis (HES and self-reported) T 379101 4361 374740 0.604 -0.50413 1.00355 0.0845 4.32 0.615423 0.998648 ENT Chronic laryngitis (HES and self-reported) T 379101 1014 378087 6.94E-05 -9.57496 119.614 1.06E-106 4.56E+97 0.936198 0.998648 ENT Vocal cord polyp (HES and self-reported) T 379101 392 378709 6.72E-05 -9.60749 198.354 9.66E-174 4.68E+164 0.961369 0.998648 ENT Otosclerosis (HES and self-reported) T 379101 416 378685 5.78E-05 -9.75819 199.274 1.37E-174 2.44E+165 0.960944 0.998648 ENT Menieres disease (HES and self-reported) T 379101 1305 377796 5.31E-05 -9.8424 120.099 3.13E-107 9.03E+97 0.934685 0.998648 Genitourinary Polycystic kidney (HES and self-reported) T 379101 1630 377471 4.13E-05 -10.0936 119.217 1.37E-106 1.25E+97 0.932527 0.998648 ENT Thyroiditis (HES and self-reported) T 379101 442 378659 6.33E-05 -9.66736 192.333 1.21E-168 3.30E+159 0.959912 0.998648 Metabolic Hypopituitarism (HES and self-reported) T 379101 446 378655 5.59E-05 -9.79206 198.972 2.39E-174 1.31E+165 0.960749 0.998648 Neurosciences Other neurological problem (HES and self-reported) T 379101 8378 370723 0.954 -0.046694 0.583762 0.304 3 0.936247 0.998648 Neurosciences Myasthenia gravis (HES and self-reported) T 379101 206 378895 0.000121 -9.01975 198.008 3.43E-173 4.27E+164 0.963667 0.998648 Infectious disease Hivaids (HES and self-reported) T 379101 309 378792 8.41E-05 -9.3833 183.133 1.09E-160 6.47E+151 0.959136 0.998648 Infectious disease Tuberculosis tb (HES and self-reported) T 379101 1905 377196 3.81E-05 -10.1761 117.845 1.86E-105 7.80E+95 0.931187 0.998648 Infectious disease Malaria (HES and self-reported) T 379101 480 378621 4.83E-05 -9.9388 198.499 5.22E-174 4.46E+164 0.960067 0.998648 Infectious disease Helicobacter pylori (HES and self-reported) T 379101 1773 377328 4.35E-05 -10.0436 118.938 2.49E-106 7.59E+96 0.932704 0.998648 Haematology Clotting disorderexcessive bleeding (HES and self-reported) T 379101 2706 376395 6.72E-05 -9.60717 73.3476 2.47E-67 1.83E+58 0.89579 0.998648 Haematology Anaemia (HES and self-reported) T 379101 17268 361833 1.46 0.377229 0.34526 0.741 2.87 0.274572 0.998648 Haematology Pancytopenia (HES and self-reported) T 379101 406 378695 6.36E-05 -9.66228 196.084 7.83E-172 5.17E+162 0.960699 0.998648 Haematology Neutropenialymphopenia (HES and self-reported) T 379101 2972 376129 6.23E-05 -9.68284 73.0829 3.85E-67 1.01E+58 0.894596 0.998648 Haematology Hereditarygenetic haematological disorder (HES and self-reported) T 379101 463 378638 5.33E-05 -9.83927 199.194 1.48E-174 1.92E+165 0.960604 0.998648 Immuno-inflammation Eczemadermatitis (HES and self-reported) T 379101 11296 367805 0.679 -0.387134 0.583653 0.216 2.13 0.507141 0.998648 Immuno-inflammation Psoriasis (HES and self-reported) T 379101 5583 373518 1.45 0.373993 0.583929 0.463 4.57 0.521862 0.998648 Immuno-inflammation Blisteringdesquamating skin disorder (HES and self-reported) T 379101 748 378353 8.70E-05 -9.35016 121.086 7.39E-108 1.02E+99 0.938449 0.998648 Digestive system Malabsorptioncoeliac disease (HES and self-reported) T 379101 2523 376578 7.17E-05 -9.54313 73.1688 3.74E-67 1.37E+58 0.896229 0.998648 Digestive system Duodenal ulcer (HES and self-reported) T 379101 4066 375035 1.34 0.291191 0.714662 0.33 5.43 0.683676 0.998648 Digestive system Diverticular diseasediverticulitis (HES and self-reported) T 379101 26531 352570 1.03 0.033819 0.33178 0.54 1.98 0.918812 0.998648 Digestive system Colitisnot crohns or ulcerative colitis (HES and self-reported) T 379101 15433 363668 1.06 0.059081 0.417574 0.468 2.4 0.887486 0.998648 Digestive system Rectal or colon adenomapolyps (HES and self-reported) T 379101 28246 350855 1.15 0.144031 0.303818 0.637 2.09 0.635451 0.998648 Digestive system Inflammatory bowel disease (HES and self-reported) T 379101 4246 374855 4.21E-05 -10.0765 73.4694 1.22E-67 1.45E+58 0.89091 0.998648 Digestive system Crohns disease (HES and self-reported) T 379101 1818 377283 3.63E-05 -10.2229 121.214 2.40E-108 5.49E+98 0.932788 0.998648 Digestive system Ulcerative colitis (HES and self-reported) T 379101 3555 375546 5.06E-05 -9.89186 73.4131 1.64E-67 1.56E+58 0.892815 0.998648 Musculoskeletal Rheumatoid arthritis (HES and self-reported) T 379101 6232 372869 0.908 -0.096913 0.713303 0.224 3.67 0.891928 0.998648 Musculoskeletal Osteoarthritis (HES and self-reported) T 379101 58523 320578 0.818 -0.20146 0.256627 0.494 1.35 0.432436 0.998648 Musculoskeletal Gout (HES and self-reported) T 379101 6858 372243 0.712 -0.33979 0.717124 0.175 2.9 0.635625 0.998648 Musculoskeletal Other joint disorder (HES and self-reported) T 379101 9807 369294 1.41 0.344377 0.455495 0.578 3.45 0.44962 0.998648 Neurosciences Diabetic neuropathyulcers (HES and self-reported) T 379101 546 378555 4.64E-05 -9.97884 195.135 3.66E-171 5.87E+161 0.959215 0.998648 Neurosciences Posttraumatic stress disorder (HES and self-reported) T 379101 723 378378 9.23E-05 -9.29026 120.178 4.65E-107 1.83E+98 0.938381 0.998648 Neurosciences Anorexiabulimiaother eating disorder (HES and self-reported) T 379101 336 378765 8.96E-05 -9.32056 185.892 5.22E-163 1.54E+154 0.960011 0.998648 Digestive system Hiatus hernia (HES and self-reported) T 379101 27678 351423 0.676 -0.391336 0.389132 0.315 1.45 0.314577 0.998648 Digestive system Sclerosing cholangitis (HES and self-reported) T 379101 454 378647 5.61E-05 -9.78832 195.459 2.35E-171 1.34E+162 0.96006 0.998648 Musculoskeletal Sciatica (HES and self-reported) T 379101 5455 373646 0.489 -0.715012 1.00354 0.0684 3.5 0.47616 0.998648 Musculoskeletal Psoriatic arthropathy (HES and self-reported) T 379101 1087 378014 2.54 0.930912 1.00421 0.354 18.2 0.353922 0.998648 Musculoskeletal Cervical spondylosis (HES and self-reported) T 379101 4865 374236 1.19 0.174905 0.71331 0.294 4.82 0.8063 0.998648 Cardiovascular Rheumatic fever (HES and self-reported) T 379101 3026 376075 6.34E-05 -9.6657 71.5455 7.97E-66 5.05E+56 0.892534 0.998648 Immuno-inflammation Chronic fatigue syndrome (HES and self-reported) T 379101 1921 377180 1.44 0.367269 1.00449 0.202 10.3 0.714642 0.998648 Cardiovascular Wolff parkinson white wpw syndrome (HES and self-reported) T 379101 228 378873 0.000106 -9.14794 198.899 5.26E-174 2.15E+165 0.963316 0.998648 Cardiovascular Irregular heart beat (HES and self-reported) T 379101 1395 377706 4.87E-05 -9.9303 119.39 1.15E-106 2.06E+97 0.933712 0.998648 Cardiovascular Sick sinus syndrome (HES and self-reported) T 379101 373 378728 6.96E-05 -9.57299 192.736 6.06E-169 7.99E+159 0.960386 0.998648 Cardiovascular Svt supraventricular tachycardia (HES and self-reported) T 379101 2281 376820 2.35 0.856439 0.7129 0.582 9.52 0.229617 0.998648 Cardiovascular Aortic stenosis (HES and self-reported) T 379101 1728 377373 4.15E-05 -10.0897 115.471 2.12E-103 8.11E+93 0.930371 0.998648 Neurosciences Brain haemorrhage (HES and self-reported) T 379101 1057 378044 6.42E-05 -9.65423 118.472 9.16E-106 4.49E+96 0.935053 0.998648 Cardiovascular Varicose veins (HES and self-reported) T 379101 11798 367303 1.18 0.165192 0.455874 0.483 2.88 0.71708 0.998648 Cardiovascular Lymphoedema (HES and self-reported) T 379101 527 378574 4.80E-05 -9.94352 197.071 8.54E-173 2.70E+163 0.959759 0.998648 ENT Labyrinthitis (HES and self-reported) T 379101 839 378262 8.02E-05 -9.43143 120.901 9.79E-108 6.56E+98 0.93782 0.998648 ENT Vertigo (HES and self-reported) T 379101 697 378404 9.99E-05 -9.211 119.639 1.45E-106 6.89E+97 0.938631 0.998648 Digestive system Pyloric stenosis (HES and self-reported) T 379101 250 378851 9.69E-05 -9.24209 196.39 6.54E-172 1.43E+163 0.962465 0.998648 Digestive system Appendicitis (HES and self-reported) T 379101 6308 372793 1.67 0.510019 0.507381 0.616 4.5 0.3148 0.998648 Genitourinary Anal fissure (HES and self-reported) T 379101 269 378832 8.85E-05 -9.33215 199.412 1.60E-174 4.90E+165 0.962674 0.998648 Genitourinary Haemorrhoids piles (HES and self-reported) T 379101 1010 378091 2.53 0.928268 1.0052 0.353 18.1 0.355766 0.998648 Digestive system Primary biliary cirrhosis (HES and self-reported) T 379101 237 378864 0.000124 -8.99863 193.589 2.02E-169 7.55E+160 0.962925 0.998648 Digestive system Jaundice unknown cause (HES and self-reported) T 379101 1143 377958 5.82E-05 -9.751 120.104 3.39E-107 1.00E+98 0.935292 0.998648 Digestive system Gastroenteritisdysentry (HES and self-reported) T 379101 8121 370980 1.36 0.304866 0.507734 0.501 3.67 0.548211 0.998648 Digestive system Dyspepsia indigestion (HES and self-reported) T 379101 11162 367939 1.24 0.218264 0.456034 0.509 3.04 0.632214 0.998648 Digestive system Abdominal hernia (HES and self-reported) T 379101 20644 358457 0.96 -0.041288 0.370727 0.464 1.98 0.911324 0.998648 Digestive system Umbilical hernia (HES and self-reported) T 379101 3644 375457 0.681 -0.383663 1.00469 0.0951 4.88 0.702556 0.998648 Digestive system Inguinal hernia (HES and self-reported) T 379101 15351 363750 1.12 0.115877 0.398194 0.514 2.45 0.771046 0.998648 Genitourinary Cystitis (HES and self-reported) T 379101 2918 376183 0.96 -0.040558 1.00451 0.134 6.88 0.967794 0.998648 Genitourinary Pyelonephritis (HES and self-reported) T 379101 1141 377960 6.32E-05 -9.66984 120.168 3.25E-107 1.23E+98 0.935864 0.998648 Genitourinary Prostatitis (HES and self-reported) T 379101 1555 377546 1.57 0.450202 1.00926 0.217 11.3 0.655547 0.998648 Genitourinary Erectile dysfunction impotence (HES and self-reported) T 379101 497 378604 5.24E-08 -16.7641 5960.94 0 Inf 0.997756 0.998648 Genitourinary Kidney nephropathy (HES and self-reported) T 379101 417 378684 5.81E-05 -9.75359 197.158 8.71E-173 3.88E+163 0.960544 0.998648 Genitourinary Iga nephropathy (HES and self-reported) T 379101 666 378435 0.000102 -9.18612 119.557 1.74E-106 6.02E+97 0.938755 0.998648 Metabolic Graves disease (HES and self-reported) T 379101 476 378625 5.67E-05 -9.77828 194.776 9.05E-171 3.55E+161 0.959961 0.998648 Neurosciences Trigemminal neuralgia (HES and self-reported) T 379101 464 378637 5.64E-05 -9.78243 197.5 4.33E-173 7.36E+163 0.960496 0.998648 Neurosciences Benign essential tremor (HES and self-reported) T 379101 270 378831 9.42E-05 -9.27019 195.345 4.93E-171 1.80E+162 0.96215 0.998648 Neurosciences Polio poliomyelitis (HES and self-reported) T 379101 280 378821 8.49E-05 -9.37394 194.109 5.01E-170 1.44E+161 0.961483 0.998648 Eye Macular degeneration (HES and self-reported) T 379101 2130 376971 1.29 0.251588 1.00698 0.179 9.26 0.802709 0.998648 Eye Dry eyes (HES and self-reported) T 379101 847 378254 3.42 1.23095 1.00648 0.476 24.6 0.22132 0.998648 Musculoskeletal Disc problem (HES and self-reported) T 379101 8039 371062 0.657 -0.420531 0.711772 0.163 2.65 0.554639 0.998648 Musculoskeletal Disc degeneration (HES and self-reported) T 379101 2914 376187 0.918 -0.085692 1.00386 0.128 6.57 0.931974 0.998648 Musculoskeletal Back pain (HES and self-reported) T 379101 14806 364295 0.722 -0.325414 0.507325 0.267 1.95 0.521243 0.998648 Musculoskeletal Spinal stenosis (HES and self-reported) T 379101 3421 375680 0.778 -0.250947 1.00453 0.109 5.57 0.80273 0.998648 Musculoskeletal Joint pain (HES and self-reported) T 379101 8344 370757 1.64 0.497514 0.455594 0.673 4.02 0.274828 0.998648 Musculoskeletal Arthritis nos (HES and self-reported) T 379101 13143 365958 0.849 -0.164097 0.50922 0.313 2.3 0.747262 0.998648 Musculoskeletal Plantar fascitis (HES and self-reported) T 379101 448 378653 5.43E-05 -9.82154 199.54 7.63E-175 3.86E+165 0.960743 0.998648 Musculoskeletal Carpal tunnel syndrome (HES and self-reported) T 379101 9101 370000 0.29 -1.23638 1.004 0.0406 2.08 0.218156 0.998648 Musculoskeletal Fibromyalgia (HES and self-reported) T 379101 1223 377878 6.14E-05 -9.69747 116.859 2.07E-104 1.82E+95 0.933864 0.998648 Musculoskeletal Dupuytrens contracture (HES and self-reported) T 379101 3300 375801 5.79E-05 -9.75647 70.0539 1.35E-64 2.48E+55 0.889236 0.998648 Musculoskeletal Neck probleminjury (HES and self-reported) T 379101 520 378581 4.52E-05 -10.0049 199.464 7.37E-175 2.77E+165 0.959996 0.998648 Immuno-inflammation Acneacne vulgaris (HES and self-reported) T 379101 277 378824 9.29E-05 -9.28398 195.907 1.62E-171 5.34E+162 0.962203 0.998648 Immuno-inflammation Lichen planus (HES and self-reported) T 379101 627 378474 0.00012 -9.02506 119.344 3.11E-106 4.66E+97 0.93972 0.998648 Immuno-inflammation Lichen sclerosis (HES and self-reported) T 379101 542 378559 5.25E-05 -9.85497 190.223 6.29E-167 4.38E+157 0.958682 0.998648 Gynaecology and Obstetrics Ovarian problem (HES and self-reported) T 379101 4956 374145 4.41E-08 -16.9362 2192.04 0 Inf 0.993835 0.998648 Gynaecology and Obstetrics Cervical problem (HES and self-reported) T 379101 6385 372716 0.442 -0.816537 1.00748 0.0613 3.18 0.417668 0.998648 Gynaecology and Obstetrics Cervical intraepithelial neoplasia cin precan (HES and self-reported) T 379101 1670 377431 4.95E-08 -16.8204 3614.32 0 Inf 0.996287 0.998648 Gynaecology and Obstetrics Cervical polyps (HES and self-reported) T 379101 3066 376035 6.97E-08 -16.4797 2210.57 0 Inf 0.994052 0.998648 Gynaecology and Obstetrics Menorrhagia unknown cause (HES and self-reported) T 379101 12816 366285 1.19 0.176032 0.468702 0.476 2.99 0.707235 0.998648 Gynaecology and Obstetrics Pelvic inflammatory disease pid (HES and self-reported) T 379101 4037 375064 1.46 0.381105 0.719056 0.358 5.99 0.596107 0.998648 Gynaecology and Obstetrics Ectopic pregnancy (HES and self-reported) T 379101 539 378562 5.78E-08 -16.6659 5873.41 0 Inf 0.997736 0.998648 Gynaecology and Obstetrics Miscarriage (HES and self-reported) T 379101 1976 377125 4.56E-08 -16.9027 3519.92 0 Inf 0.996169 0.998648 Gynaecology and Obstetrics Breast fibroadenoma (HES and self-reported) T 379101 1450 377651 6.02E-05 -9.71793 111.226 1.26E-99 2.86E+90 0.930377 0.998648 Musculoskeletal Raynauds phenomenondisease (HES and self-reported) T 379101 1315 377786 5.30E-05 -9.84471 119.957 4.12E-107 6.82E+97 0.934592 0.998648 Immuno-inflammation Food intolerance (HES and self-reported) T 379101 306 378795 7.84E-05 -9.4541 197.811 3.27E-173 1.88E+164 0.961881 0.998648 Immuno-inflammation Urticaria (HES and self-reported) T 379101 530 378571 4.73E-05 -9.95919 199.326 1.01E-174 2.21E+165 0.960151 0.998648 Infectious disease Infectious mononucleosis glandular fever epste (HES and self-reported) T 379101 517 378584 4.31E-05 -10.0527 197.975 1.30E-173 1.43E+164 0.959503 0.998648 Infectious disease Measles morbillivirus (HES and self-reported) T 379101 1296 377805 1.87 0.627701 1.00431 0.262 13.4 0.531968 0.998648 Infectious disease Mumps epidemic parotitis (HES and self-reported) T 379101 830 378271 2.9 1.06515 1.00463 0.405 20.8 0.289034 0.998648 Infectious disease Rubella german measles (HES and self-reported) T 379101 452 378649 4.95E-05 -9.91286 197.507 3.75E-173 6.55E+163 0.959971 0.998648 Infectious disease Chickenpox (HES and self-reported) T 379101 1557 377544 1.54 0.433447 1.00434 0.215 11 0.66605 0.998648 Infectious disease Shingles (HES and self-reported) T 379101 734 378367 3.65 1.29446 1.00492 0.509 26.2 0.197702 0.998648 Infectious disease Herpes simplex (HES and self-reported) T 379101 373 378728 6.59E-05 -9.62688 199.509 9.85E-175 4.41E+165 0.961515 0.998648 Infectious disease Hepatitis c (HES and self-reported) T 379101 331 378770 7.92E-05 -9.44345 194.792 1.23E-170 5.12E+161 0.961334 0.998648 Cardiovascular Ischaemic stroke (HES and self-reported) T 379101 2968 376133 1.82 0.598545 0.714984 0.448 7.39 0.402512 0.998648 Cardiovascular Mitral regurgitation incompetence (HES and self-reported) T 379101 2024 377077 2.65 0.973305 0.71497 0.652 10.7 0.173411 0.998648 Cardiovascular Aortic valve disease (HES and self-reported) T 379101 2405 376696 1.1 0.092737 1.00627 0.153 7.89 0.926572 0.998648 Cardiovascular Aortic regurgitation incompetence (HES and self-reported) T 379101 711 378390 3.71 1.3118 1.00593 0.517 26.7 0.19221 0.998648 Cardiovascular Hypertrophic cardiomyopathy hcm hocm (HES and self-reported) T 379101 265 378836 9.21E-05 -9.29304 196.543 4.61E-172 1.84E+163 0.962288 0.998648 Cardiovascular Pericarditis (HES and self-reported) T 379101 1193 377908 2.17 0.774761 1.005 0.303 15.6 0.440761 0.998648 Cardiovascular Varicose ulcer (HES and self-reported) T 379101 232 378869 0.000109 -9.12827 195.625 3.28E-171 3.59E+162 0.962783 0.998648 Respiratory Respiratory infection (HES and self-reported) T 379101 9656 369445 1.72 0.541402 0.417957 0.757 3.9 0.195199 0.998648 Respiratory Pleural plaques not known asbestosis (HES and self-reported) T 379101 690 378411 3.83 1.34379 1.01301 0.526 27.9 0.184666 0.998648 ENT Tinnitus tiniitis (HES and self-reported) T 379101 1088 378013 6.03E-05 -9.71655 120.024 4.11E-107 8.84E+97 0.935478 0.998648 ENT Tonsiltis (HES and self-reported) T 379101 3534 375567 4.87E-05 -9.93013 73.2454 2.19E-67 1.08E+58 0.892159 0.998648 Digestive system Constipation (HES and self-reported) T 379101 9731 369370 0.563 -0.573647 0.71221 0.14 2.28 0.420562 0.998648 Digestive system Bowel intestinal perforation (HES and self-reported) T 379101 387 378714 6.66E-05 -9.61692 197.703 3.43E-173 1.29E+164 0.961204 0.998648 Digestive system Bowel intestinal infarction (HES and self-reported) T 379101 264 378837 0.000101 -9.19561 196.723 3.57E-172 2.89E+163 0.962717 0.998648 Digestive system Bowel intestinal obstruction (HES and self-reported) T 379101 3937 375164 0.69 -0.370579 1.00393 0.0965 4.94 0.712033 0.998648 Digestive system Rectal prolapse (HES and self-reported) T 379101 1030 378071 7.18E-05 -9.54093 118.309 1.41E-105 3.66E+96 0.935725 0.998648 Digestive system Alcoholic liver disease alcoholic cirrhosis (HES and self-reported) T 379101 824 378277 3.25 1.17931 1.00763 0.451 23.4 0.241846 0.998648 Digestive system Femoral hernia (HES and self-reported) T 379101 643 378458 0.00011 -9.11801 119.528 1.98E-106 6.09E+97 0.939194 0.998648 Genitourinary Diabetic nephropathy (HES and self-reported) T 379101 242 378859 0.000103 -9.18119 194.167 5.42E-170 1.95E+161 0.962286 0.998648 Genitourinary Nephritis (HES and self-reported) T 379101 1824 377277 3.72E-05 -10.2004 119.378 8.98E-107 1.54E+97 0.931906 0.998648 Genitourinary Glomerulnephritis (HES and self-reported) T 379101 1746 377355 3.90E-05 -10.1526 119.351 9.93E-107 1.53E+97 0.93221 0.998648 Metabolic Hyperparathyroidism (HES and self-reported) T 379101 788 378313 3.49 1.25054 1.00558 0.487 25.1 0.213646 0.998648 Eye Blepharitis eyelid infection (HES and self-reported) T 379101 653 378448 0.000103 -9.18539 119.96 7.92E-107 1.33E+98 0.938965 0.998648 Mental health Stress (HES and self-reported) T 379101 662 378439 4.01 1.38982 1.00461 0.56 28.8 0.166528 0.998648 Mental health Obsessive compulsive disorder ocd (HES and self-reported) T 379101 208 378893 0.000112 -9.09806 198.055 2.89E-173 4.33E+164 0.96336 0.998648 Mental health Insomnia (HES and self-reported) T 379101 5225 373876 0.487 -0.718653 1.00414 0.0681 3.49 0.474182 0.998648 Musculoskeletal Osteopenia (HES and self-reported) T 379101 990 378111 8.11E-05 -9.42029 113.176 3.73E-101 1.76E+92 0.933664 0.998648 Musculoskeletal Soft tissue inflammation (HES and self-reported) T 379101 9317 369784 1.16 0.15037 0.507432 0.43 3.14 0.766973 0.998648 Musculoskeletal Tendonitis tendinitis tenosynovitis (HES and self-reported) T 379101 5613 373488 0.473 -0.749407 1.00364 0.0661 3.38 0.455253 0.998648 Musculoskeletal Epicondylitis (HES and self-reported) T 379101 745 378356 3.6 1.27989 1.00473 0.502 25.8 0.202711 0.998648 Musculoskeletal Tennis elbow lateral epicondylitis (HES and self-reported) T 379101 796 378305 3.35 1.20776 1.00457 0.467 24 0.22926 0.998648 Musculoskeletal Housemaids knee prepatellar bursitis (HES and self-reported) T 379101 300 378801 8.12E-05 -9.41845 194.804 1.23E-170 5.37E+161 0.961439 0.998648 Musculoskeletal Fracture skull head (HES and self-reported) T 379101 2136 376965 8.42E-05 -9.38224 72.6438 1.23E-66 5.77E+57 0.897236 0.998648 Musculoskeletal Fracture jaw (HES and self-reported) T 379101 790 378311 8.46E-05 -9.37793 118.276 1.77E-105 4.03E+96 0.936803 0.998648 Musculoskeletal Fracture nose (HES and self-reported) T 379101 1043 378058 6.12E-05 -9.70114 119.533 1.09E-106 3.43E+97 0.935316 0.998648 Musculoskeletal Fracture face orbit eye socket (HES and self-reported) T 379101 477 378624 4.96E-05 -9.91065 195.605 1.56E-171 1.58E+162 0.959591 0.998648 Musculoskeletal Fracture neck cervical fracture (HES and self-reported) T 379101 345 378756 6.74E-05 -9.60487 197.684 3.60E-173 1.26E+164 0.961248 0.998648 Musculoskeletal Fracture clavicle collar bone (HES and self-reported) T 379101 1092 378009 2.24 0.808323 1.00514 0.313 16.1 0.421287 0.998648 Musculoskeletal Fracture shoulder scapula (HES and self-reported) T 379101 2722 376379 1.96 0.674493 0.71267 0.486 7.94 0.343929 0.998648 Musculoskeletal Fracture upper arm humerus elbow (HES and self-reported) T 379101 3361 375740 1.57 0.451259 0.712555 0.389 6.35 0.52654 0.998648 Musculoskeletal Fracture forearm wrist (HES and self-reported) T 379101 8702 370399 0.932 -0.070292 0.583756 0.297 2.93 0.904156 0.998648 Musculoskeletal Fracture radius (HES and self-reported) T 379101 5082 374019 0.551 -0.596001 1.00439 0.0769 3.95 0.552914 0.998648 Musculoskeletal Fracture ulna (HES and self-reported) T 379101 1643 377458 4.10E-05 -10.1024 120.818 5.89E-108 2.85E+98 0.933361 0.998648 Musculoskeletal Fracture wrist colles fracture (HES and self-reported) T 379101 3198 375903 1.6 0.470977 0.712721 0.396 6.47 0.508731 0.998648 Musculoskeletal Fracture hand (HES and self-reported) T 379101 1148 377953 5.65E-05 -9.7804 120.434 1.73E-107 1.85E+98 0.935275 0.998648 Musculoskeletal Fracture finger (HES and self-reported) T 379101 1578 377523 1.58 0.457334 1.00456 0.221 11.3 0.648922 0.998648 Musculoskeletal Fracture thumb (HES and self-reported) T 379101 379 378722 6.12E-05 -9.70113 196.495 3.36E-172 1.11E+163 0.960624 0.998648 Musculoskeletal Fracture rib (HES and self-reported) T 379101 2085 377016 8.41E-05 -9.38311 72.5759 1.40E-66 5.04E+57 0.897131 0.998648 Musculoskeletal Fracture sternum (HES and self-reported) T 379101 240 378861 0.000106 -9.15107 197.994 3.09E-173 3.64E+164 0.963136 0.998648 Musculoskeletal Fracture vertebra crush fracture vertebral col (HES and self-reported) T 379101 1036 378065 2.53 0.928255 1.00437 0.353 18.1 0.355373 0.998648 Musculoskeletal Fracture pelvis (HES and self-reported) T 379101 555 378546 4.40E-05 -10.0322 198.902 2.16E-174 8.95E+164 0.959773 0.998648 Musculoskeletal Fracture neck of femur hip (HES and self-reported) T 379101 2221 376880 8.56E-05 -9.36592 72.1583 3.24E-66 2.26E+57 0.896727 0.998648 Musculoskeletal Fracture shaft of femur (HES and self-reported) T 379101 596 378505 0.000109 -9.12694 120.588 2.45E-107 4.82E+98 0.939668 0.998648 Musculoskeletal Fracture patella knee (HES and self-reported) T 379101 515 378586 4.78E-05 -9.94823 199.467 7.76E-175 2.95E+165 0.960223 0.998648 Musculoskeletal Fracture lower leg ankle (HES and self-reported) T 379101 6609 372492 1.2 0.185253 0.583719 0.383 3.78 0.750965 0.998648 Musculoskeletal Fracture tibia (HES and self-reported) T 379101 1942 377159 8.94E-05 -9.32255 73.3672 3.16E-67 2.53E+58 0.898887 0.998648 Musculoskeletal Fracture fibula (HES and self-reported) T 379101 749 378352 8.46E-05 -9.37728 120.718 1.48E-107 4.84E+98 0.938083 0.998648 Musculoskeletal Fracture foot (HES and self-reported) T 379101 1193 377908 5.43E-05 -9.82012 120.894 6.73E-108 4.39E+98 0.93526 0.998648 Musculoskeletal Fracture metatarsal (HES and self-reported) T 379101 436 378665 5.42E-05 -9.8221 199.744 5.11E-175 5.75E+165 0.960781 0.998648 Musculoskeletal Fracture toe (HES and self-reported) T 379101 413 378688 5.63E-05 -9.78531 198.798 3.39E-174 9.34E+164 0.960742 0.998648 Infectious disease Septicaemia sepsis (HES and self-reported) T 379101 3840 375261 2.1 0.740165 0.58504 0.666 6.6 0.205816 0.998648 Neurosciences Meningioma benign meningeal tumour (HES and self-reported) T 379101 499 378602 5.20E-05 -9.86412 196.305 4.15E-172 6.52E+162 0.959924 0.998648 Immuno-inflammation Rosacea (HES and self-reported) T 379101 850 378251 7.82E-05 -9.45562 121.09 6.60E-108 9.28E+98 0.937758 0.998648 Gynaecology and Obstetrics Cervical erosion (HES and self-reported) T 379101 898 378203 9.20E-08 -16.2016 3570.46 0 Inf 0.996379 0.998648 Gynaecology and Obstetrics Abnormal smear cervix (HES and self-reported) T 379101 1903 377198 4.29E-08 -16.9651 3613.5 0 Inf 0.996254 0.998648 Gynaecology and Obstetrics Dysmenorrhoea dysmenorrhea (HES and self-reported) T 379101 1606 377495 2.03 0.706037 1.01148 0.279 14.7 0.485164 0.998648 Gynaecology and Obstetrics Menopausal symptoms menopause (HES and self-reported) T 379101 9705 369396 0.587 -0.533491 0.719443 0.143 2.4 0.45837 0.998648 Gynaecology and Obstetrics Benign breast lump (HES and self-reported) T 379101 2336 376765 3.56E-05 -10.2422 111.505 4.33E-100 2.93E+90 0.926814 0.998648 Immuno-inflammation Allergy to house dust mite (HES and self-reported) T 379101 279 378822 8.32E-05 -9.394 199.284 1.93E-174 3.58E+165 0.962403 0.998648 Infectious disease Scarlet fever scarlatina (HES and self-reported) T 379101 435 378666 5.71E-05 -9.77072 196.494 3.14E-172 1.04E+163 0.960341 0.998648 Genitourinary Undescended testicle (HES and self-reported) T 379101 210 378891 4.20E-08 -16.9862 9881.82 0 Inf 0.998628 0.998648 Cancer Bowens disease (HES and self-reported) T 379101 617 378484 4.28E-05 -10.0585 193.202 1.50E-169 1.23E+160 0.958479 0.998648 Neurosciences Benign neuroma (HES and self-reported) T 379101 590 378511 0.000111 -9.10928 120.955 1.22E-107 1.01E+99 0.939967 0.998648 Musculoskeletal Fracture head neck (HES and self-reported) T 379101 2134 376967 8.46E-05 -9.37751 72.7102 1.08E-66 6.60E+57 0.897381 0.998648 Musculoskeletal Fracture upper limb shoulder (HES and self-reported) T 379101 10515 368586 1.04 0.03713 0.50748 0.384 2.81 0.941675 0.998648 Musculoskeletal Other fractures (HES and self-reported) T 379101 5304 373797 1.5 0.407883 0.584211 0.478 4.73 0.485066 0.998648 Musculoskeletal Fracture pelvis lower limb (HES and self-reported) T 379101 8374 370727 0.963 -0.037584 0.583902 0.307 3.02 0.948679 0.998648 Musculoskeletal OA under age 50 T 327093 14899 312194 0.727 -0.319161 0.508436 0.268 1.97 0.53018 0.998648 Musculoskeletal Osteoarthritis all T 370717 58523 312194 0.825 -0.19291 0.257174 0.498 1.36 0.453185 0.998648 Musculoskeletal Osteoarthritis hip T 322974 10780 312194 1.22 0.201361 0.461562 0.495 3.02 0.662648 0.998648 Musculoskeletal Osteoarthritis knee T 330411 18217 312194 0.716 -0.333397 0.458885 0.291 1.76 0.46751 0.998648 Musculoskeletal Osteoarthritis knee or hip T 339616 27422 312194 0.958 -0.043051 0.333117 0.499 1.84 0.897171 0.998648 Musculoskeletal Osteoarthritis non load bearing joints T 317066 4872 312194 0.551 -0.595158 1.00542 0.0769 3.96 0.553886 0.998648 Musculoskeletal BIN combinedFractures T 379101 28020 351081 1.14 0.131443 0.301862 0.631 2.06 0.663244 0.998648 Cardiovascular Pulse minimumValue T 357246 NA NA NA 0.039048 0.085729 -0.128981 0.207077 0.64876 0.998648 Other Sleep duration T 376797 NA NA NA 0.016664 0.083626 -0.147244 0.180572 0.842051 0.998648 Other Sleeplessness insomnia T 378601 NA NA NA 0.088665 0.083279 -0.074561 0.251891 0.287021 0.998648 Other Daytime dozing sleeping narcolepsy T 377552 NA NA NA -0.044199 0.083158 -0.207189 0.118792 0.595072 0.998648 Cardiovascular Ventricular rate T 8941 NA NA NA 0.600039 0.999205 -1.3584 2.55848 0.548162 0.998648 Cardiovascular P duration T 8939 NA NA NA 0.34455 0.99973 -1.61492 2.30402 0.730363 0.998648 Cardiovascular QRS duration T 8939 NA NA NA -0.169224 0.999064 -2.12739 1.78894 0.865495 0.998648 Cardiovascular Cardiac index during PWA T 8000 NA NA NA 0.455614 0.999219 -1.50286 2.41408 0.648411 0.998648 Summary Number of self reported non cancer illnesses T 379040 NA NA NA 0.099992 0.083256 -0.063191 0.263174 0.229747 0.998648 Summary Number of operations self reported T 379040 NA NA NA -0.029899 0.083296 -0.193159 0.133362 0.71964 0.998648 Summary Number of treatments medications taken T 379040 NA NA NA 0.1075 0.083261 -0.055692 0.270692 0.196662 0.998648 Family history Father s age at death T 278550 NA NA NA 0.082629 0.096508 -0.106527 0.271784 0.391894 0.998648 Other Townsend deprivation index at recruitment T 378649 NA NA NA -0.085601 0.082809 -0.247907 0.076705 0.301271 0.998648 Neurosciences Fluid intelligence score T 184529 NA NA NA 0.06482 0.112999 -0.156658 0.286298 0.566218 0.998648 Neurosciences Prospective memory result T 126279 NA NA NA -0.075415 0.124417 -0.319272 0.168443 0.544417 0.998648 ENT Speech reception threshold SRT estimate left T 114702 NA NA NA 0.063039 0.130992 -0.193706 0.319783 0.630345 0.998648 ENT Speech reception threshold SRT estimate right T 114815 NA NA NA 0.08644 0.130951 -0.170224 0.343104 0.509194 0.998648 Neurosciences Mean time to correctly identify matches T 376457 NA NA NA 0.037894 0.083199 -0.125176 0.200963 0.648776 0.998648 Family history Alzheimer s disease dementia (family history) T 379101 NA NA NA -0.012237 0.08306 -0.175034 0.150561 0.882877 0.998648 Family history Parkinson s disease (family history) T 379101 NA NA NA 0.002697 0.083009 -0.160001 0.165395 0.974083 0.998648 Family history Severe depression (family history) T 379101 NA NA NA 0.036018 0.083117 -0.126891 0.198926 0.664769 0.998648 Family history Prostate cancer (family history) T 174719 NA NA NA -0.049833 0.116354 -0.277887 0.178221 0.668441 0.998648 Family history Heart disease (family history) T 379101 NA NA NA -0.112069 0.083269 -0.275276 0.051138 0.178346 0.998648 Family history Stroke (family history) T 379101 NA NA NA 0.075186 0.083158 -0.087804 0.238176 0.365925 0.998648 Family history Lung cancer (family history) T 379101 NA NA NA 0.044111 0.083151 -0.118865 0.207088 0.59577 0.998648 Family history Bowel cancer (family history) T 379101 NA NA NA 0.071277 0.082994 -0.091391 0.233944 0.390438 0.998648 Family history Diabetes (family history) T 379101 NA NA NA 0.004499 0.083122 -0.15842 0.167417 0.95684 0.998648 Mental health Neuroticism score T 307275 NA NA NA -0.115042 0.090906 -0.293218 0.063134 0.205689 0.998648 Neurosciences Number of incorrect matches in round T 93587 NA NA NA -0.028184 0.157776 -0.337424 0.281057 0.858228 0.998648 Anthropometry Weight T 377979 NA NA NA -0.006043 0.083308 -0.169327 0.157241 0.942175 0.998648 Cardiovascular Pulse wave Arterial Stiffness index T 124962 NA NA NA 0.106462 0.128009 -0.144436 0.35736 0.405593 0.998648 Musculoskeletal Falls in the last year T 378169 NA NA NA -0.02979 0.083366 -0.193186 0.133606 0.720836 0.998648 Anthropometry Body fat percentage T 372255 NA NA NA 0.101278 0.084023 -0.063408 0.265963 0.228067 0.998648 Anthropometry Whole body fat mass T 371851 NA NA NA 0.054896 0.084159 -0.110056 0.219849 0.514214 0.998648 Anthropometry Whole body fat free mass T 372439 NA NA NA -0.067157 0.083966 -0.23173 0.097416 0.423818 0.998648 Anthropometry Whole body water mass T 372469 NA NA NA -0.066664 0.083968 -0.231242 0.097914 0.427243 0.998648 Other Relative age of first facial hair T 168858 NA NA NA -0.025601 0.117591 -0.256079 0.204877 0.827653 0.998648 Other Relative age voice broke T 161623 NA NA NA -0.152158 0.120248 -0.387844 0.083528 0.20574 0.998648 Other Age when periods started menarche T 198489 NA NA NA 0.154358 0.121206 -0.083206 0.391922 0.202834 0.998648 Biological assays Mean corpuscular volume T 367861 NA NA NA 0.116624 0.084018 -0.048051 0.281298 0.165111 0.998648 Biological assays Mean corpuscular haemoglobin concentration T 367856 NA NA NA 0.032247 0.084169 -0.132724 0.197218 0.70163 0.998648 Biological assays Red blood cell erythrocyte distribution width T 367861 NA NA NA 0.039736 0.084211 -0.125318 0.20479 0.637027 0.998648 Biological assays Mean platelet thrombocyte volume T 367857 NA NA NA 0.081997 0.084223 -0.083079 0.247073 0.330269 0.998648 Biological assays Platelet distribution width T 367857 NA NA NA 0.039537 0.084213 -0.125521 0.204595 0.63872 0.998648 Biological assays Monocyte count T 367207 NA NA NA 0.107667 0.0845 -0.057953 0.273287 0.202605 0.998648 Biological assays Neutrophill count T 367207 NA NA NA -0.103445 0.0845 -0.269066 0.062176 0.220879 0.998648 Biological assays Eosinophill count T 367207 NA NA NA -0.042054 0.084486 -0.207646 0.123538 0.618649 0.998648 Biological assays Basophill count T 367207 NA NA NA -0.053479 0.084186 -0.218484 0.111527 0.525271 0.998648 Biological assays Nucleated red blood cell count T 367198 NA NA NA 0.108471 0.084246 -0.056651 0.273593 0.197902 0.998648 Biological assays Lymphocyte percentage T 367213 NA NA NA -0.10878 0.084522 -0.274443 0.056883 0.198094 0.998648 Biological assays Neutrophill percentage T 367213 NA NA NA 0.029618 0.084519 -0.136039 0.195276 0.726013 0.998648 Biological assays Eosinophill percentage T 367213 NA NA NA 0.020165 0.084508 -0.145471 0.1858 0.811405 0.998648 Biological assays Basophill percentage T 367213 NA NA NA -0.110111 0.084511 -0.275752 0.05553 0.192604 0.998648 Biological assays Nucleated red blood cell percentage T 367195 NA NA NA 0.111997 0.084246 -0.053125 0.277119 0.183711 0.998648 Biological assays Creatinine enzymatic in urine T 368234 NA NA NA -0.094377 0.08508 -0.261134 0.072379 0.267309 0.998648 Biological assays Potassium in urine T 367438 NA NA NA -0.116307 0.085105 -0.283113 0.050499 0.171743 0.998648 Biological assays Sodium in urine T 367460 NA NA NA -0.068134 0.085005 -0.234743 0.098476 0.422828 0.998648 Respiratory FVC maximumValue T 286167 NA NA NA -0.117711 0.09821 -0.310203 0.074781 0.230697 0.998648 Respiratory FVC maximumValue strict T 221665 NA NA NA -0.100342 0.110732 -0.317377 0.116693 0.364846 0.998648 Family history Mother s age at death T 223081 NA NA NA -0.030213 0.104161 -0.234369 0.173942 0.771767 0.998648 Gynaecology and Obstetrics Age started hormone replacement therapy HRT T 71387 NA NA NA -0.02596 0.20843 -0.434483 0.382563 0.90088 0.998648 Gynaecology and Obstetrics Age at menopause last menstrual period T 116962 NA NA NA 0.159462 0.154064 -0.142503 0.461427 0.30065 0.998648 Neurosciences Incorect matches summed T 379101 NA NA NA -0.051901 0.083239 -0.215049 0.111247 0.532942 0.998648 Cancer Reported occurrences of cancer T 61110 NA NA NA 0.131772 0.213688 -0.287056 0.5506 0.53746 0.998648 Cardiovascular Systolic blood pressure mean T 357243 NA NA NA -0.028394 0.085724 -0.196412 0.139624 0.740474 0.998648 Neurosciences Maximum digits remembered correctly T 116653 NA NA NA -0.024217 0.136049 -0.290873 0.242439 0.858722 0.998648 Mental health Happiness T 126053 NA NA NA 0.069017 0.125023 -0.176028 0.314062 0.580926 0.998648 Anthropometry Waist circumference T 378432 NA NA NA 0.002993 0.083315 -0.160304 0.16629 0.971341 0.998648 Anthropometry Hip circumference T 378389 NA NA NA 0.06803 0.083305 -0.095248 0.231308 0.414135 0.998648 Eye LogMAR final left T 83967 NA NA NA -0.198471 0.168868 -0.529452 0.13251 0.239873 0.998648 Eye Corneal hysteresis right T 81176 NA NA NA 0.019504 0.168939 -0.311617 0.350624 0.908091 0.998648 Eye Corneal resistance factor right T 81176 NA NA NA -0.130219 0.168999 -0.461457 0.201019 0.440983 0.998648 Eye Intra ocular pressure corneal compensated left T 81056 NA NA NA -0.225632 0.169022 -0.556915 0.105651 0.181899 0.998648 Eye Corneal hysteresis left T 81056 NA NA NA -0.028389 0.169003 -0.359634 0.302857 0.866601 0.998648 Eye Corneal resistance factor left T 81056 NA NA NA -0.167155 0.169039 -0.498471 0.164161 0.322736 0.998648 Other Overall acceleration average T 81471 NA NA NA -0.031229 0.164351 -0.353357 0.290899 0.849297 0.998648 Respiratory FEV1 never smoked only T 109851 NA NA NA -0.173301 0.147134 -0.461684 0.115082 0.238859 0.998648 ENT Hear loss B T 121038 NA NA NA 0.079169 0.127626 -0.170978 0.329316 0.535047 0.998648 Other NumCigarettes T 111875 NA NA NA -0.159316 0.195939 -0.543356 0.224724 0.416165 0.998648 Biological assays Urine albumin creatinine ratio T 114295 NA NA NA -0.058277 0.138632 -0.329996 0.213442 0.674213 0.998648 Ordered by FDR. The category "Summary" indicates cases were anyone with admission for any code in the block. * Lung function measures described as "strict" only include individuals with passed-QC spirometry (see reference 16 in the main Table S4. Interactions between the SERPINA1 Z allele and smoking status or sex in UK Biobank participants

FEV (ml) FEV /FVC FVC (ml) COPD Interaction Genetic model 1 1 beta se p beta se p beta se p OR 95% CI p Z*EVERSMK Heterozygous 20.782 9.107 0.022 0.0044 0.0011 1.06x10-4 6.587 10.899 0.546 1.311.10-1.58 0.003 Z*EVERSMK Recessive 192.066 103.651 0.064 0.045 0.013 5.06x10-4 60.088 124.033 0.628 1.460.51-4.28 0.484 Z*sex Heterozygous 6.821 9.13 0.455 0.0042 0.0011 0.00021 -12.351 10.927 0.258 0.880.74-1.05 0.153 Z*sex Recessive 57.606 100.578 0.567 0.026 0.013 0.041 -18.799 120.356 0.876 1.180.41-3.34 0.755

Results are based on linear (or logistic, in the case of COPD) regression adjusting for sex, age, age2, height, ever-smoking, ancestry-based principal components, and genotyping array. The heterozygous or recessive genetic model was also included in the regression as shown. Males were coded as 1 and females as 2, so a positive interaction coefficient means there was a more positive coefficient in females compared to males and a negative interaction coefficient means there was a less positive coefficient in females compared to males. Ever-smoking status was coded 1 if the individual had ever-smoked and 2 if the individual had never smoked. Table S5. Association of heterozygosity for the SERPINA1 Z allele with height and lung function in individuals aged 8, 15, and 24

a Age Height (cm) FEV1/FVC (years) N beta se p N beta se p 8 5,162 0.064 0.385 0.869 4,838 0.023 0.071 0.744 15 4,023 0.452 0.512 0.378 2,930 0.016 0.086 0.848 24 2,766 0.493 0.558 0.376 2,131 0.078 0.096 0.415

Data derived from study participants in the ALSPAC study. aAge, sex, and height adjusted Z scores Table S6. Association between the SERPINA1 Z allele and lung function traits in UK Biobank male and female never- and ever-smokers

FEV1 (ml) FEV1/FVC FVC (ml) COPD Genetic model Subgroup OR (95% beta se p beta se p beta se p p CI) Male 1.04 (0.84- never- 17.013 11.346 0.134 0.00087 0.0012 0.478 15.941 13.751 0.246 0.689 1.28) smokers Female 0.73 (0.59- never- 20.493 6.251 0.001 0.0045 0.00086 1.75x10-7 10.265 7.72 0.184 0.005 0.91) smokers Heterozygous Male ever- 1.16 (1.01- -13.986 11.327 0.217 -0.0036 0.0013 7.55x10-3 1.672 13.204 0.899 0.028 smokers 1.33) Female 1.16 (0.98- ever- 9.974 8.142 0.221 0.00027 0.0012 0.821 9.896 9.682 0.307 0.081 1.36) smokers Male 5.26 (1.46- never- -184.651 111.011 0.096 -0.033 0.012 6.81x10-3 -155.016 134.511 0.249 0.004 14.78) smokers Female 6.28 (2.07- never- -158.256 67.643 0.019 -0.034 0.0093 2.20x10-4 -55.679 83.539 0.505 2.65x10-4 15.50) smokers Recessive Male ever- 8.37 (3.01- -422.885 133.09 0.0015 -0.106 0.016 1.84x10-11 -103.271 155.115 0.506 1.64x10-5 smokers 21.51) Female 10.77 ever- -314.24 102.273 0.0021 -0.05 0.015 9.14x10-4 -258.857 121.59 0.033 (2.95- 5.60x10-5 smokers 31.82) Results are based on linear (or logistic, in the case of COPD) regression adjusting for age, age2, height, ancestry-based principal components, and genotyping array. The heterozygous or recessive genetic model was also included in the regression as shown