Host Defense 2013 Antigen Presentation and the MHC Herbert L. Mathews, Ph.D.
ANTIGEN PRESENTATION and the MHC
Date: 3/27/13 Reading Assignment: Janeway’s Immunobiology, 8th Edition, pp. 29-31, 202-209, 210-214, 342-344.
Figures: (Unless otherwise noted) Janeway’s Immunobiology, 8th Edition, Murphy et al., Garland Publishing.
KEY CONCEPTS AND LEARNING OBJECTIVES
You will be able to describe the role of antigen presenting cells in the development of the immune response with emphasis upon the role of the major histocompatibility complex. You will be able to describe the process of naive lymphocyte activation.
To attain competence for this lecture you will be able to:
a. List the different types of antigen presenting cells. b. Compare and contrast MHC class I and class II antigen presentation. c. Identify the signals required to activate T-lymphocytes. d. Describe the immune synapse.
Page 1 Host Defense 2013 Antigen Presentation and the MHC Herbert L. Mathews, Ph.D.
CONTENT SUMMARY
Introduction
The Major Professional Antigen Presenting Cells
Antigen Processing
MHC Class I Antigen Processing
MHC Class II Antigen Processing
MHC Class I Restricted Presentation of antigen to T lymphocytes
Activation of Naïve T Cells by Interaction with Antigen Presenting Cells
Activation of Naive T Cells by Interaction with Antigen Presenting Cells That Do Not Express B7
Cellular Reactions Required for Antibody Production
Immune Synapse
Overview of the Cellular Interaction of the Immune Response
Page 2 Host Defense 2013 Antigen Presentation and the MHC Herbert L. Mathews, Ph.D.
INTRODUCTION