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Natural History of Odontogenic Infection
Natural History of Odontogenic Infection The usual cause of odontogenic infections is necrosis of the pulp of the tooth, which is followed by bacterial invasion through the pulp chamber and into the deeper tissues. Necrosis of the pulp is the result of deep caries in the tooth, to which the pulp responds with a typical inflammatory reaction. Vasodilation and edema cause pressure in the tooth and severe pain as the rigid walls of the tooth prevent swelling. If left untreated the pressure leads to strangulation of the blood supply to the tooth through the apex and consequent necrosis. The necrotic pulp then provides a perfect setting for bacterial invasion into the bone tissue. Once the bacteria have invaded the bone, the infection spreads equally in all directions until a cortical plate is encountered. During the time of intrabony spread, the patient usually experiences sufficient pain to seek treatment. Extraction of the tooth (or removal of the necrotic pulp by an endodontic procedure) results in resolution of the infection. Direction of Spread of Infection The direction of the infection's spread from the tooth apex depends on the thickness of the overlying bone and the relationship of the bone's perforation site to the muscle attachments of the jaws. If no treatment is provided for it, the infection erodes through the thinnest, nearest cortical plate of bone and into the overlying soft tissue. If the root apex is centrally located, the infection erodes through the thinnest bone first. In the maxilla the thinner bone is the labial-buccal side; the palatal cortex is thicker. -
Renal Ischemia/Reperfusion Injury: Functional Tissue Preservation by Anti-Activated 1 Integrin Therapy
Renal Ischemia/Reperfusion Injury: Functional Tissue Preservation by Anti-Activated 1 Integrin Therapy Ana Molina,* Marı´a Ubeda,* Marı´a M. Escribese,* Laura Garcı´a-Bermejo,* David Sancho,† ʈ Guillermo Pe´rez de Lema,‡ Fernando Lian˜o,§ Carlos Caban˜as, Francisco Sa´nchez-Madrid,† and Francisco Mampaso* *Department of Pathology, Hospital Ramo´n y Cajal, Universidad de Alcala´, Madrid, Spain; †Department of Immunology, Hospital de la Princesa, Universidad Auto´noma de Madrid, Madrid, Spain; ‡Medizinische Poliklinic der Ludwig Maximillians-Universitat, Munich, Germany; §Department of Nephrology, Hospital Ramo´n y Cajal, ʈ Universidad de Alcala´, Madrid, Spain; and Institute of Pharmacology and Toxicology (Centro Mixto CSIC-UCM), Facultad de Medicina, Universidad Complutense, Madrid, Spain Renal ischemia/reperfusion injury (IRI) is an important cause of acute renal failure. Cellular and molecular responses of the kidney to IRI are complex and not fully understood. 1 integrins localize to the basal surface of tubular epithelium interacting with extracellular matrix components of the basal membrane, including collagen IV. Whether preservation of tubular epithelium integrity could be a therapeutic approach for IRI was assessed. The effects of HUTS-21 mAb administration, which recognizes an activation-dependent epitope of 1 integrins, in a rat model of IRI were investigated. Preischemic HUTS-21 administration resulted in the preservation of renal functional and histopathologic parameters. Analyses of activated 1 integrins expression and focal adhesion kinase phosphorylation suggest that its deactivation after IRI was prevented by HUTS-21 treatment. Moreover, HUTS-21 impaired the inflammatory response in vivo, as indicated by inhibition of proin- flammatory mediators and the absence of infiltrating cells. -
Hemidesmosomes and Focal Adhesions Treadmill As Separate but Linked Entities During Keratinocyte Migration Anne Pora1, Sungjun Yoon1, Reinhard Windoffer1 and Rudolf E
ORIGINAL ARTICLE See related commentary on pg 1854 Hemidesmosomes and Focal Adhesions Treadmill as Separate but Linked Entities during Keratinocyte Migration Anne Pora1, Sungjun Yoon1, Reinhard Windoffer1 and Rudolf E. Leube1 Hemidesmosomes anchor the epidermal keratin filament cytoskeleton to the extracellular matrix. They are crucial for the mechanical integrity of skin. Their role in keratinocyte migration, however, remains unclear. Examining migrating primary human keratinocytes, we find that hemidesmosomes cluster as ordered arrays consisting of multiple chevrons that are flanked by actin-associated focal adhesions. These hemidesmosomal arrays with intercalated focal adhesions extend from the cell rear to the cell front. New hemidesmosomal chevrons form subsequent to focal adhesion assembly at the cell’s leading front, whereas chevrons and associated focal adhesions disassemble at the cell rear in reverse order. The bulk of the hemidesmosome-focal adhesion composite, however, remains attached to the substratum during cell translocation. Similar hemidesmosome-focal adhesion patterns emerge on X-shaped fibronectin-coated micropatterns, during cell spreading and in leader cells during collective cell migration. We further find that hemidesmosomes and focal adhesions affect each other’s distribution. We propose that both junctions are separate but linked entities, which treadmill coordinately to support efficient directed cell migration and cooperate to coordinate the dy- namic interplay between the keratin and actin cytoskeleton. Journal of Investigative Dermatology (2019) 139, 1876e1888; doi:10.1016/j.jid.2019.03.1139 INTRODUCTION are characterized by HD-specific a6/b4 integrin hetero- Epithelial cell migration is a key process in physiological dimers, which are connected through plakins to keratins situations, such as tissue morphogenesis, and in pathological (Nahidiazar et al., 2015). -
Rebanho De Búfalos Leiteiros, FMVZ-USP, Campus De Pirassununga, SP
Rebanho de búfalos leiteiros, FMVZ-USP, campus de Pirassununga, SP Bubalus bubalis bubalis MARIA ZILAH BENETONE Apoptose e proliferação na placenta de búfalas São Paulo 2005 MARIA ZILAH BENETONE Apoptose e proliferação na placenta de búfalas Dissertação apresentada ao Programa de Pós-graduação em Anatomia dos Animais Domésticos e Silvestres da Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo para obtenção do título de Mestre em Ciências Departamento: Cirurgia Área de Concentração: Anatomia dos Animais Domésticos e Silvestres Orientadora: Profa Dra Maria Angélica Miglino São Paulo 2005 Autorizo a reprodução parcial ou total desta obra, para fins acadêmicos, desde que citada a fonte. DADOS INTERNACIONAIS DE CATALOGAÇÃO-NA-PUBLICAÇÃO (Biblioteca da Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo) T.1616 Benetone, Maria Zilah FMVZ Apoptose e proliferação na placenta de búfalas / Maria Zilah Benetone. -- São Paulo : M. Z. Benetone, 2005. 186 f. : il. Dissertação (mestrado) - Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia. Departamento de Cirurgia, 2005. Programa de Pós-graduação: Anatomia dos Animais Domésticos e Silvestres. Área de concentração: Anatomia dos Animais Domésticos e Silvestres. Orientador: Profa. Dra. Maria Angélica Miglino. 1. Apoptose. 2. Placenta. 3. Búfalo. 4. Caspase. 5. Proliferação. I. Título. FOLHA DE AVALIAÇÃO Nome: BENETONE, Maria Zilah Título: Apoptose e proliferação na placenta de búfalas Dissertação apresentada ao Programa de Pós-graduação em Anatomia dos Animais Domésticos e Silvestres da Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo para obtenção do título de Mestre em Ciências Data: _____/_____/_____ Banca Examinadora Prof. Dr. -
The Functions of Uterine Secretions R
Printed in Great Britain J. Reprod. Fert. (1988) 82,875-892 @ 1988 Journals of Reproduction & Fertility Ltd The functions of uterine secretions R. M. Roberts and F. W. Bazer Departments of Biochemistry and Animal Sciences, University of Missouri, Columbia, MO 65211, U.S.A.; and Department of Animal Science, University of Florida, Gainesville, FL 32611, U.S.A. Summary. The likely functions of uterine secretions, often termed histotroph, in the nurture of the early conceptus are reviewed. Particular emphasis has been placed on the pig in which the uterus synthesizes and secretes large amounts of protein in response to progesterone. In this species, which possesses a non-invasive, diffuse type of epithelio- chorial placentation, the secretions provide a sustained embryotrophic environment which is distinct from that of serum. A group of basic proteins dominates these uterine secretions after Day 1 1 of pregnancy and its best characterized member is uteroferrin, an iron-containing acid phosphatase with a deep purple colour. Evidence has accumulated to suggest that uteroferrin, rather than functioning as an acid phosphatase, is involved in transporting iron to the conceptus. Three basic polypeptides which are found non- covalently associated with uteroferrin have been shown to be antigenically closely related to one another and to have arisen by post-translational processing from a common precursor molecule. Their function is unknown. A group of basic protease inhibitors has been identified which bear considerable sequence homology to bovine pancreatic trypsin inhibitor (aprotinin) and may control intrauterine proteolytic events initiated by the conceptuses. The last basic protein so far characterized is lysozyme which is presumed to have an antibacterial role. -
Universidade Estadual De Campinas Faculdade De Ciências Médicas Carlos Vinícius Buarque De Gusmão Efeito Do Ultrassom, Ondas
UNIVERSIDADE ESTADUAL DE CAMPINAS FACULDADE DE CIÊNCIAS MÉDICAS CARLOS VINÍCIUS BUARQUE DE GUSMÃO EFEITO DO ULTRASSOM, ONDAS DE CHOQUE E DE PRESSÃO RADIAL NO REPARO DE DEFEITOS ÓSSEOS NAS TÍBIAS DE RATOS AVALIADO PELA EXPRESSÃO E ATIVIDADE DE AKT, BMP-2, ERK-2, FAK E TGF-β1 EFFECT OF ULTRASOUND, EXTRACORPOREAL SHOCKWAVES AND RADIAL PRESSURE WAVES ON AKT, BMP-2, ERK-2, FAK AND TGF-β1 DURING BONE HEALING IN RAT TIBIAL DEFECTS CAMPINAS 2018 CARLOS VINÍCIUS BUARQUE DE GUSMÃO EFEITO DO ULTRASSOM, ONDAS DE CHOQUE E DE PRESSÃO RADIAL NO REPARO DE DEFEITOS ÓSSEOS NAS TÍBIAS DE RATOS AVALIADO PELA EXPRESSÃO E ATIVIDADE DE AKT, BMP-2, ERK-2, FAK E TGF-β1 EFFECT OF ULTRASOUND, EXTRACORPOREAL SHOCKWAVES AND RADIAL PRESSURE WAVES ON AKT, BMP-2, ERK-2, FAK AND TGF-β1 DURING BONE HEALING IN RAT TIBIAL DEFECTS Tese apresentada à Faculdade de Ciências Médicas da Universidade Estadual de Campinas como parte dos requisitos exigidos para a obtenção do título de Doutor em Ciências. Thesis presented to the Faculty of Medical Sciences of the State University of Campinas as part of the requirements to obtain the title of Doctor in Sciences. ORIENTADOR: PROF. DR. WILLIAM DIAS BELANGERO ESTE EXEMPLAR CORRESPONDE À VERSÃO FINAL DA TESE DEFENDIDA PELO ALUNO CARLOS VINÍCIUS BUARQUE DE GUSMÃO, E ORIENTADO PELO PROF. DR. WILLIAM DIAS BELANGERO. CAMPINAS 2018 Agência(s) de fomento e nº(s) de processo(s): CAPES, 02-P-3369/2017; FAPESP, 2014/26729-0 Ficha catalográfica Universidade Estadual de Campinas Biblioteca da Faculdade de Ciências Médicas Maristella Soares dos Santos - CRB 8/8402 Gusmão, Carlos Vinícius Buarque de, 1986- G972e Efeito do ultrassom, ondas de choque e de pressão radial no reparo de defeitos ósseos nas tíbias de ratos avaliado pela expressão e atividade de Akt, BMP-2, ERK-2, FAK e TGF-b1 / Carlos Vinícius Buarque de Gusmão. -
Mammalogy Lecture 12
Mammalogy Lecture 11 - Reproduction I: General Patterns I. Obviously, reproduction is a very important aspect of biology and whole courses are dedicated to it. It’s easy to understand why reproductive traits would be subject to strong selection because of their direct effects on fitness. II. As we might expect, there are three basic types of mammalian reproduction. These correspond to the three major groups of mammals. Differences among these types reflect the degree of intimacy of fetal-maternal contact. A. Monotreme Type - Retain the primitive amniote pattern, but add a period of lactation. - Egg is very large at ovulation, about 3 mm. It moves down the oviduct where it is fertilized, then it’s coated with albumin, then a shell is laid down by a shell gland, and the shell is mineralized (with CaCO3). - Embryo spends 2-3 weeks in the uterus, then it’s laid. It’s large, 15 mm, when it’s laid. - Embryo growth is supported entirely by the yolk that’s enclosed in the egg. B. Metatherian type: - In some superficial ways it’s similar to monotremes, in that metatherians retain a shell membrane around the fertilized egg; a shell gland is present in Müllerian ducts. - However the shell is never mineralized and young are born live after only ca. 12 days, as we’ve seen, they are very altricial (poorly developed). - Initial intrauterine growth is supported by maternally by a placenta. - Metatherian placenta is the choriovitelline type - yolk-sac placenta (Eutherian placenta is called chorioallantoic placenta) C. Placenta Formation - Let’s look at formation of the placenta in Meta- & Eutherians. -
Nbde Part 2 Decks and Remembed-Arroz Con Mango
ARROZ CON MANGO Dear friends, these are remembered/repeated questions (RQs) and answers I COPIED and PASTED from different discussions on Facebook. I feel sorry because I couldn’t organize the file the way I wanted but I hope it helps. Probably you’ll find some wrong answers in this file, but PLEASE … DO NOT CRITICIZE! Find out the right answer, learn it, share it, PASS your test and BE HAPPY J I wish you all the best GOD BLESS YOU! PAITO 1. All of the following are adverse effects of opioids except? diarrhea and somnolence 2. Advantage of osteogenesis distraction is? less relapse, large movements 3. An investigation that is not accurate but consistent is: reliability 4. Remineralized enamel is rough and cavitation? Dark hard and opaque 5. Characteristics of a child with autism - repetitive action, sensitive to light and noise 6. S,z,che sounds : Teeth barely touching – True 7. Something about bio-transformation, more polar and less lipid soluble? - True 8. How much of he population has herpes? 80% - (65-90% worldwide; 80-85% USA) More than 3.7 billion people under the age of 50 – or 67% of the population – are infected with herpes simplex virus type 1 (HSV-1), according to WHO's first global estimates of HSV-1 infection published today in the journal PLOS ONE. 9. Steps of plaque formation: pellicle, biofilm, materia alba, plaque 10. Dose of hydrocortisone taken per year that will indicate have adrenal insufficiency and need supplement dose for surgery - 20 mg 2 weeks for 2 years 11. Rpd clasp breakage due to what? Work hardening 12. -
Nomina Histologica Veterinaria, First Edition
NOMINA HISTOLOGICA VETERINARIA Submitted by the International Committee on Veterinary Histological Nomenclature (ICVHN) to the World Association of Veterinary Anatomists Published on the website of the World Association of Veterinary Anatomists www.wava-amav.org 2017 CONTENTS Introduction i Principles of term construction in N.H.V. iii Cytologia – Cytology 1 Textus epithelialis – Epithelial tissue 10 Textus connectivus – Connective tissue 13 Sanguis et Lympha – Blood and Lymph 17 Textus muscularis – Muscle tissue 19 Textus nervosus – Nerve tissue 20 Splanchnologia – Viscera 23 Systema digestorium – Digestive system 24 Systema respiratorium – Respiratory system 32 Systema urinarium – Urinary system 35 Organa genitalia masculina – Male genital system 38 Organa genitalia feminina – Female genital system 42 Systema endocrinum – Endocrine system 45 Systema cardiovasculare et lymphaticum [Angiologia] – Cardiovascular and lymphatic system 47 Systema nervosum – Nervous system 52 Receptores sensorii et Organa sensuum – Sensory receptors and Sense organs 58 Integumentum – Integument 64 INTRODUCTION The preparations leading to the publication of the present first edition of the Nomina Histologica Veterinaria has a long history spanning more than 50 years. Under the auspices of the World Association of Veterinary Anatomists (W.A.V.A.), the International Committee on Veterinary Anatomical Nomenclature (I.C.V.A.N.) appointed in Giessen, 1965, a Subcommittee on Histology and Embryology which started a working relation with the Subcommittee on Histology of the former International Anatomical Nomenclature Committee. In Mexico City, 1971, this Subcommittee presented a document entitled Nomina Histologica Veterinaria: A Working Draft as a basis for the continued work of the newly-appointed Subcommittee on Histological Nomenclature. This resulted in the editing of the Nomina Histologica Veterinaria: A Working Draft II (Toulouse, 1974), followed by preparations for publication of a Nomina Histologica Veterinaria. -
Student to Student Guides
Harvard School of Dental Medicine Student-to-Student Guide to Clinic: How to Excel in Third Year 2010-2011 Edition Adam Donnell Mindy Gil Brandon Grunes Sharon Jin Aram Kim Michelle Mian Tracy Pogal-Sussman Kim Whippy 1999 – Blaine Langberg & Justine Tompkins 2000 – Blaine Langberg & Justine Tompkins 2001 – Blaine Langberg & Justine Tompkins 2002 – Mark Abel & David Halmos 2003 – Ketan Amin 2004 – Rishita Saraiya & Vanessa Yu 2005 – Prathima Prasanna & Amy Crystal 2006 – Seenu Susarla & Brooke Blicher 2007 – Deepak Gupta & Daniel Cassarella 2008 – Bryan Limmer & Josh Kristiansen 2009 – Byran Limmer & Josh Kristiansen 2010 – Adam Donnell, Tracy Pogal-Sussman, Kim Whippy, Mindy Gil, Sharon Jin, Brandon Grunes, Aram Kim, Michelle Mian 1 2 Foreword Dear Class of 2012, We present the 12th edition of this guide to you to assist your transition from the medical school to the HSDM clinic. You have accomplished an enormous amount thus far, but the transformation to come is beyond expectation. Third year is challenging, but fun; you‘ll look back a year from now with amazement at the material you‘ve learned, the skills you‘ve acquired, and the new language that gradually becomes second nature. To ease this process, we would like to share with you the material in this guide, starting with lessons from our own experience. Course material is the bedrock of third year. Without knowing and fully understanding prevention, disease control, and the basics of dentistry, even the most technically skilled dental student can not provide patients with successful treatment. Be on time to lectures, don‘t be afraid to ask questions, and take some time to review your notes in the evening. -
Anatomy of the Gallbladder and Bile Ducts
BASIC SCIENCE the portal vein lies posterior to these structures; Anatomy of the gallbladder the inferior vena cava, separated by the epiploic foramen (the foramen of Winslow) lies still more posteriorly, and bile ducts behind the portal vein. Note that haemorrhage during gallbladder surgery may be Harold Ellis controlled by compression of the hepatic artery, which gives off the cystic branch, by passing a finger through the epiploic foramen (foramen of Winslow), and compressing the artery Abstract between the finger and the thumb placed on the anterior aspect A detailed knowledge of the gallbladder and bile ducts (together with of the foramen (Pringle’s manoeuvre). their anatomical variations) and related blood supply are essential in At fibreoptic endoscopy, the opening of the duct of Wirsung the safe performance of both open and laparoscopic cholecystectomy can usually be identified quite easily. It is seen as a distinct as well as the interpretation of radiological and ultrasound images of papilla rather low down in the second part of the duodenum, these structures. These topics are described and illustrated. lying under a characteristic crescentic mucosal fold (Figure 2). Unless the duct is obstructed or occluded, bile can be seen to Keywords Anatomical variations; bile ducts; blood supply; gallbladder discharge from it intermittently. The gallbladder (Figures 1 and 3) The biliary ducts (Figure 1) The normal gallbladder has a capacity of about 50 ml of bile. It concentrates the hepatic bile by a factor of about 10 and also The right and left hepatic ducts emerge from their respective sides secretes mucus into it from the copious goblet cells scattered of the liver and fuse at the porta hepatis (‘the doorway to the throughout its mucosa. -
Equine Placenta – Marvelous Organ and a Lethal Weapon
Equine placenta – marvelous organ and a lethal weapon Malgorzata Pozor, DVM, PhD, Diplomate ACT Introduction Placenta has been defined as: „an apposition between parent (usually maternal) and fetal tissue in order to establish physiological exchange” (1). Another definition of this important organ was proposed by Steven and Morris: „a device consisting of one or more transport epithelia located between fetal and maternal blood supply” (2). The main function of placenta is to provide an interface between the dam and the the fetus and to allow the metabolic exchange of the the nutrients, oxygen and waste material. The maternal circulation is brought into a close apposition to the fetal circulation, while a separation of these two circulatory systems remain separated (3). A degree and complexity of this „intimate relationship” varies greately between species mostly due to the structural diversity of the extraembryonic membranes of the vertebrates. The early feto-maternal exchange in the equine pregnancy is established as early as on day 22 after fertilization. The fetal and choriovitellin circulations are already present, the capsule ruptures and the allantois is already visible (4). The allantois starts expanding by day 32 and vascularizes approximately 90% of the chorion and fuses with it to form chorioallantois by day 38 of gestation (5). The equine placenta continues increasing its complexity till approximately day 150 of gestation. Equids have epitheliochorial placenta, there are six leyers separating maternal and fetal circulation, and there are no erosion of the luminal, maternal epithelium, like in ruminants (6). Thousands of small chorionic microvilli develop and penetrate into endometrial invaginations.