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MEDICC Review January 2021 Vol 23, No 1 Adverse Events Following Immunization in Cuba 35 Cuban Biotech’s Hepatitis Vaccines 21 Hypothermia for Oxygen-Deprived Neonates 30 Global Review of Mother-to-Child Transmission 72 US–Cuba Collaboration 89 Cuban Genetics Studies 12 Appeal for Comprehensive Surveillance 92 Cuban Physician on Serving in Italy 18 Peer reviewed since 2007 www.mediccreview.org Editor-in-Chief C. William Keck MD MPH FACPM Executive Editor Gail Reed MS Senior Editor, English Edition Caitlin Baird PhD January 2021, Vol 23, No 1 Senior Editor Conner Gorry MA EDITORIAL Primary Issue Coordinator 4 Build Back Better: Leadership for US–Cuba Health Cooperation Jorge Bacallao PhD DSc ABOUT THE CONTRIBUTORS Issue Coordinators Alina Alerm MD MS 6 Lila Castellanos PhD DSc Gisele Coutin MD MS PEER REVIEWERS 2020 Esther María Fajardo MS 9 Editorial Associates LETTERS Anna Kovac Annet Sánchez 10 COVID-19 Control in a Havana Surgical Hospital Julián F. Ruiz-Torres MD PhD, et al. Copy Editor Carolyn Gorry Dangers and Management of Obstructive Sleep Apnea Syndrome in COVID-19 Patients Communications Consultant Elizabeth Sayre MA Calixto Machado-Curbelo MD PhD FAAN Publishing & Circulation CUBA’S WOMEN OF SCIENCE – INTERVIEW Aram Álvarez MFA 12 Researchers at Cuba’s National Medical Genetics Center: Silvia García Pioneering Studies on COVID-19 Yenny Leal Gail A. Reed MS Translators Pamela Boyle INTERVIEW Roxane K. Dow MA 18 Cuba’s Medical Team in the European Epicenter of COVID-19: Kathleen Vickery MA Carlos R. Pérez-Díaz MD MS PhD Director, JoaquínAlbarrán Provincial Clinical-Surgical Hospital, Havana MEDICC Review is indexed in: Henry Reeve Medical Contingent Leader, Lombardy, Italy MEDLINE®/PubMed® Gisele Coutin-Marie MD MS and Conner Gorry MA POLICY & PRACTICE 21 Cuban Prophylactic and Therapeutic Vaccines for Controlling Hepatitis B Eduardo Pentón-Arias MD PhD and Julio C. Aguilar-Rubido PhD ORIGINAL RESEARCH Global Health 30 Hypoxic Ischemic Encephalopathy in Units Reporting Tropical Diseases Bulletin ELSEVIER to the Ibero-American Society of Neonatology Network: EMBASE Prevalence and Mortality EBSCO SCOPUSTM Fernando Domínguez-Dieppa MD PhD, et al. 35 Characterization of Adverse Events Following Childhood Immunizations in Pinar del Río, Cuba Elba Cruz-Rodríguez MD MS, et al. MEDICC Review is a unique open-access platform for 43 Urinary Metabolic Disorders Associated with Urolithiasis Latin American and Caribbean praxis addressing today’s in Cuban Pediatric Patients critical interactions between human health, development of sustainable societies, and the health of our planet. Draw- Raymed A. Bacallao-Méndez MD MS, et al. ing upon the contributions of the region in social medicine, social movements, rich diversity and scientifi c prowess, 49 Short-term Tolerance of Nasally-Administered NeuroEPO in Patients Latin America and Caribbean authors published in the with Parkinson Disease journal can help fi ll gaps in thinking and evidence sorely needed to build a sustainable future and a hopeful legacy MaritéGarcía-Llano MD, et al. for future generations.We look forward to contributing to increased visibility for their work and to its positive impact 55 Evaluating Cerebral Perfusion in Alzheimer Patients and First-Degree on both regional integration and worldwide solutions. Relatives: Lessons from Artemisa Province, Cuba MEDICC Review is published by MEDICC, a US nonprofi t Yamilé Peña-Quián MD PhD, et al. organization founded in 1997, based in Oakland, Califor- nia, USA, and dedicated to US, Cuban and global health cooperation and equity. 64 Non-Alcoholic Fatty Liver Disease in Cuba Marlen I. Castellanos-Fernández MD PhD, et al. MEDICC Review online (ISSN 1527-3172) is an open- access publication: see our Creative Commons License online for details. www.mediccreview.org – Copyright © 2021, MEDICC Review January 2021, Vol 23, No 1 REVIEW ARTICLE 72 Congenital and Intrapartum SARS-CoV-2 Infection in Neonates: Hypotheses, Evidence, and Perspectives Gerardo R. Robaina-Castellanos MD PhD and Solangel de la CaridadRiesgo- Rodríguez MD MS PERSPECTIVE 84 Psychocardiology’s Contributions to Comprehensive Cardiovascular Care in Cuba Teresa Rodríguez-Rodríguez MS PhD, et al. VIEWPOINT 89 Cuba–US Collaboration: The Pandemic Imperative Roberto Cañete MD PhD and Kenneth W. Goodman PhD 90 Can Anti-Ribosomal Antibodies Improve Systemic Lupus Erythematosus Diagnosis? Elena Kokuina MD PhD 92 Comprehensive Surveillance Needed to Contain COVID-19 Saurabh RamBihariLal Shrivastava MD and Prateek Saurabh Shrivastava MD ABSTRACTS Cuban Research in Current International Journals Special Abstracts Section COVID-19 Available online only Cover photo: Production plant at the Molecular Immunology Center (CIM), Havana, Cuba. CIM produces the receptor-binding domain (RBD) of the coronavirus's spike protein that is included in the Soberana 01 and Soberana 02 vaccine candidates for COVID-19. Credit: E. Añé MEDICC Review Editorial Board Neil Arya BASc MD CCFP FCFP Tee L. Guidotti MD, MPH, DABT Daniel J. Ncayiyana MD FACOG Director, Offi ce of Global Health Consultant, Occupational & Environmental Health Emeritus Professor, University of Cape Town Schulich School of Medicine and Dentistry and Medicine, Toronto, Canada South Africa Western University, Canada Jean Handy PhD André-Jacques Neusy MD DTM&H Rifat Atun MBBS MBA FRCGP FFPH FRCP Associate Professor of Microbiology & Immunology Senior Director, Training for Health Equity Network Professor of Global Health Systems University of North Carolina School of Medicine, USA THEnet, USA Director, Health Systems Cluster Harvard University School of Public Health, USA Barbara J. Hatcher PhD MPH RN FAAN F. Javier Nieto MD PhD Associate Professor, George Mason University Dean, College of Public Health & Human Sciences Michael Bird MSW MPH College of Nursing & Health Sciences, USA Oregon State University, USA Public Health Consultant, Kewa Pueblo Health Board Urban Indian Health Commission Raúl Herrera MD PhD DSc Albuquerque, New Mexico, USA Peter Orris MD MPH Distinguished Professor, Medical University of Professor and Chief, Occupational & Environmental Havana; Chair, National Nephrology Group, Cuba Medicine, University of Illinois Hospital and Health James Boex PhD MBA Sciences System, USA Emeritus Professor of Medical Education Eve J. Higginbotham SM MD Univ. of Cincinnati College of Medicine, USA Vice Dean of Diversity & Inclusion, University of Jorge Pérez MD MS Pennsylvania Perelmen School of Medicine, USA Adviser to the Director and Full Professor Peter Bourne MD MA Pedro Kourí Tropical Medicine Institute, Cuba Visiting Senior Research Fellow Sharon K. Hull MD MPH Green Templeton College, University of Oxford, UK Founder and CEO Metta Solutions, USA Patricia Rodney PhD MPH RN Alfred Brann MD Partners in Health, Education and Development, USA Professor of Pediatrics C. William Keck MD MPH FACPM Emory University School of Medicine, USA Professor Emeritus, Family and Community María Isabel Rodríguez MD Medicine, Northeast Ohio Medical University, USA Health and Education Advisor to the President of the Jaime Breilh MD PhD MSc Republic, El Salvador Director, Health Department Ann Marie Kimball MD MPH FACPM Universidad Andina Simón Bolívar, Ecuador Senior Consulting Fellow, Chatham House Royal F. Douglas Scutchfi eld MD FACPM FAAP Institute of Foreign Affairs; Strategic Consultant in Peter P. Bosomworth Professor of Health Services Paulo M. Buss MD MPH Global Health, Rockefeller Foundation, USA Research and Policy, University of Kentucky Director, FIOCRUZ Center for Global Health Colleges of Public Health and Medicine, USA Oswaldo Cruz Foundation, Brazil Barry Kistnasamy MBChB Mmed Head, Occupational Health, Department of Health Stuart G. Shanker DPhil MA Pastor Castell-Florit MD PhD DSc South Africa Distinguished Research Professor of Philosophy and Director, National School of Public Health, Cuba Psychology; Director, Milton & Ethel Harris Research Patrick Kuma-Aboagye MB-BCH MPH Initiative, York University, Canada José F. Cordero MD MPH Deputy Director and Head Patel Distinguished Professor of Public Health Reproductive and Child Health Department Augusto Sola MD Chair, Department of Epidemiology and Biostatistics Ghana Health Service, Ghana Neonatologist, St Jude’s Hospital and Children’s College of Public Health, University of Georgia, USA Hospital, Orange County, California, USA Albert Kuperman PhD Yamila de Armas MD Emeritus Associate Dean for Medical Education Ronald St. John MD MPH Professor, National School of Public Health, Cuba Albert Einstein College of Medicine of Yeshiva President, St. John Public Health Consulting University, USA International, Canada Maria Cecilia de Souza Minayo MS PhD Professor of Sociology Margaret Larkins-Pettigrew MD MEd MPPM Pedro Urra MS National School of Public Health, Brazil Assistant Professor, Global Health/OB-GYN and Full Professor, University of Havana, Cuba Reproductive Biology, Univ Hospitals, Case Medical Center & MacDonald Women’s Hospital, USA Timothy De Ver Dye PhD MS MA MPA Pedro A. Valdés-Sosa MD PhD Professor, OB–GYN and Pediatrics Deputy Director, Neuroscience Center, Cuba Public Health Sciences and Medical Informatics Linh Cu Le MD MSc PhD University of Rochester School of Medicine and Associate Professor of Public Health Dentistry, USA Vinmec International Hospital JSC, Viet Nam Luis F. Vélez MD MPH PhD Director, Program Development, Evaluation and Quality Improvement Roger Downer PhD DSc FRSC MRIA Noni MacDonald MD MSc FRCPC FCAHS DePelchin Children’s Center,