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The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. VOLUME 111 NUMBER 5 THE JOURNAL OF IMMUNOLOGY ® Contents for November

CELLULAR IMMUNOLOGY The Role of Humoral Factors in the Initiation of In Vitro Primary Immune Re- sponses. III. Characterization of Factors that Replace Thymus-derived Cells. JAMES WATSON...... 1301 Specific Heterotogous Enhancement of Immune Responses. V. Isolation of a Soluble Enhancing Factor from Supernatants of Specifically Stimulated and Allo- geneically Induced Lymphoid Cells. ARNOLDS. RUBIN, A. BRUCE MAcDoNALD,

AND ALBERT H. COONS ...... 1314 Differentiation of Lymphoid Cells: Effect of Serum and Other Mitogenic Agents on the Selective Induction of Immunoglobulin M Secreting Lymph Node Cells in

Tissue Culture. DANIEL H. ZIMMnRMANAND MILTON KERN...... 1326 Downloaded from Immunoglobulin (Ig) Allotype Markers on Rabbit Lymphocytes: Separation of Cells Bearing Different Allotypes and Demonstration of the Binding of Ig to Lymphoid Cell Membranes. PATRICIAP. JONES, JOHN J. CEBRA, AND LEONARD A. HERZENBERG ...... 1334 Vitamin A: Adjuvant and Steroid Antagonist in the Immune Response. BENJAMIN E. COHEN AND I. KVLMAN COHEN...... 1376 Induction of Cell-Mediated Immunity and Tolerance to Homologous Collagen in Guinea Pigs: Demonstration of Antigen-Reactive Cells for a Self-Antigen. GEORGE SENYK AND Dov MICHAELI ...... 1381 http://www.jimmunol.org/ Reaginie Antibody Formation in the Mouse. III. Collaboration Between Hapten- Specific Memory Cells and Carrier-Specific Helpers Cells for Secondary Anti- Hap ten Antibody Formation. HIROKAZUOKUDAIRA AND KIMIamGE ISHIZAKA.. 1420 Reversible Inhibition of Lymphocyte-Mediated Cytolysis by Dimethyl Sulfoxide (DMSO). GFRALD WOLBERG, KAY HIEMSTRA, JOSEPH J. BURGE, AND ROBERT C. SINGLES...... 1435 Complement Receptors on Cell Membranes. I. Evidence for Two Complement Re- ceptors. HIDnCHIKAOKADA AND KUSUYANISHIOKA ...... 1444 Lymphocyte-Derived Eosinophil Chemotactic Factor. II. Studies on the Mechanism of Activation of the Precursor Substance by Immune Complexes. MOTOMICHI ToRIsu, TAKESHI YOSH1DA, PETER A. WARD, AND STANLEY COHEN ...... 1450 Long-term Survival of Mouse Thymic Lymphoid Cells In Vitro: Effect of Human by guest on September 28, 2021 Serum. KEIKOOZATO ...... 1459 Studies of Thoracic Duct Lymphocytes of Mice. III. Cell Surface Antigen Charac- teristics. MARK A. MANVEL, TOSHITADO TAKAHASm, ANn LLOYD J. OLD ...... 1474 .... ), Presence of Impairment of Humoral Immunity in Nonadherent Spleen Cells of Old Mice. MARGARETL. HEIDRICK AND T. MAKINODAN...... 1502 Lymphocytes in Peyer's Patches of the Mouse: Analysis of the Constituent Cells in Terms of Their Capacities to Mediate Functions of Mature T and B Lympho- cytes. DAWDH. KATZ AND DANIEL Y. E. PEREY ...... 1507 Immune Responses in Vitro. IX: Role of Cell Clusters. JOHN A. MCINTYRE AND CARL W. PIERCE ...... 1526 An Effector-Cell Independent Step in Target Cell Lysis by Sensitized Mouse Lym- phocytes. ERIC MARTZ AND BARUJ BENACERRAF ...... 1538 A Mathematical Model for the Quantitation of Tumor and Antibody-Forming Cell Populations within an Animal's Body. I{AY~OND N. HIRAMOTO, VITHAL K. GHANTA, JI':RRY R. McGHEE, AND N. MARLENE H~I,IN ...... 1546 Cellular Site of Action of Various Adjuvants in Antibody Responses to Hapten- Carrier Conjugates. TosmYuKI HAMAOKAAND DAVID H. KATZ...... 1554 IMMUNOCHEMISTRY A Light Chain Tyrosyl Sequence in the Antibody Site of a Rabbit Anti-p-Azobenzoate Antibody. O. A. ROHOLT, B. FmEDENSON, G. RADZIMSKI,AND D. PRESSMAN. 1367 The Reaction of Zymosan with the Properdin System in Normal and C4-Deficient Guinea Pig Serum: Demonstration of C3- andC5-Cleaving Multi-unit Enzymes, Both Containing Factor B, and Acceleration of Their Formation by the Clas- sical Complement Pathway. VOLKER BRADE, GEaA~ D. LEE, ANNE NICHOL- SON, HYUN S. SHIN, AND MaNFREn M. MAYER ...... 1389 Analysis of Antibody Populations to Oligo-Alanine Determinants. III. The Par- ticipation of Subclasses IgG~ and IgG~ in the Antibody Response in Inbred Mice. HUBERTKOLn AND EBZRHARDTWEXLER ...... 1479 Analysis of Antibody Populations to Oligo-Alanine Determinants. IV. Functional Similarity of Variable Regions of IgG~ and IgG~ Antibodies. HUBERT KOLB AND EBERHARDT WEILER...... 1487

Continued Contents continued Identification of J-Chain in Polymeric Immunoglobulins from a Variety of Species by Cross-Reaction with Rabbit Antisera to Human J-Chain. KUNIHIKO KOBAYASHI, JEAN-PIERRE VAERMAN, HERV~ BAZIN, ANNE-MARIE LEBACQ- VERHEYDEN~ AND JOSEPH F. HEREMANS ...... 1590 IMMUNOGENETICS AND TRANSPLANTATION Cellular Studies of the Genetic Control of Immune Response toward the Loop Region of Lysozome. EDNA MOZES, G. M. SHEARER, ELCHANAN MARON, RUTH ARNON, AND MICHAEL SELA ...... 1429 Genetic Control of Thymus-Derived Cell Function. III. DNA Synthetic Responses of Rat Lymph Node Cells Stimulated in Culture with Concanavalin A and Phytohemagglutinin. R. MICHAEL WILLIAMS, MICHAEL J. MOORE, AND BARUJ

BENACERRAF ...... 1571 Genetic Control of Thymus-Derived Cell Function. IV. Mitogen Responsiveness and Mixed Lymphocyte Reactivity of Thymus Cells and Lymph Node Ceils from Lewis and Brown Norway Rats. R. MICHAEL WILLIAMS, MICHAEL J. MOORE, AND BARUJ BENACERRAF...... 1579

IMMUNOPATHOLOGY Downloaded from Mechanisms of Endotoxin Tolerance. VIII. Specificity of Serum Transfer. SHELDON E. GREISMAN, EDWARD J. YOUNG, AND BERNARD DuBuY ...... 1349 Role of Ca++ in Mast Cell Activation, Desensitization, and Histamine Release by Dextran. JAMESH. BAXTER...... 1470 Detection of Slow Reacting Substance of Anaphylaxis (SRS-A) in Plasma of Guinea Pigs During Anaphylaxis. DANIEL J. STECHSHULTE, ROBERT P. ORANGE, AND K. FRANK AUSTEN ...... 1585 http://www.jimmunol.org/ TUMOR IMMUNOLOGY Lymphocyte Populations of AKR/J Mice. I. Effect of Aging on Migration Patterns, Response to PHA and Expression of Theta Antigen. MARIONM. ZATZ, ALLAN L. GOLDSTEIN, AND ABRAHAM WHITE ...... 1514 Lymphocyte Populations of AKR/J Mice. II. Effect of Leukemogenesis on Migration Patterns, Response to PHA, and Expression of Theta Antigen. MARION M. ZATZ, ABRAHAM WHITE, AND ALLAN L. GOLDSTEIN ...... 1519 VIRAL AND MICROBIAL IMMUNOLOGY Studies of Antibodies to Non-Type-Specific Antigens Associated with Streptococcal M Protein in the Sera of Patmnts with Rheumatic Fever. EDWINH. BEACHEY, by guest on September 28, 2021 ITZHAK OFEK, AND ALAN L. BISNO ...... 1361 A Surface Component in Group A, C, and G Streptococci with Non-Immune Reac- tivity for Immunoglobulin G. GORANKRONVALL ...... 1401 Failure to Demonstrate a Humoral Immune Response to Scrapie Infection in Mice. DAVID D. PORTER, HELEN G. PORTER, AND NANCY A. Cox ...... 1407 Evidence for a Macrophage-Mediated Effect of Poliovirus on the Lymphocyte Re- sponse to Phytohemagglutinin. F.J.C.J. SOONTIi~NS AND J. VAN DER VEEN.. 1411 Role of Humoral and Cell-Mediated Immunity on the Recovery of Chickens from Fowlpox Virus Infection. CHIHARU MORITA ...... 1495 An Agglutination-Flocculation Test for Rapid Detection of Hepatitis B Antigen. ZARAH F. KACHANI AND DAVID J. GOCKE ...... 1564 COMMUNICATIONS Endogenous Synthesis of Membrane b5 by Lymphocytes from Rabbits Recovering from b5 Allotype Suppression. MICHAEL R. HARRISON, PATRICIA P. JONES, AND ROSE G. MAGE...... 1595 Alternate Complement Pathway: Elevation of Cobra Venom-Induced Hemolytic Activity in Sera of Tumor-Bearing Mice. MELCHIORREBRAI AND ABRAHAMG. OSLER ...... 1598 Thymus Dependence of Reaginic Antibody Formation in Mice. J. GABRIELMICHAEL

AND I. LEONARD BERNSTEIN ...... 1600 Selective Activation of Chicken T Lymphocytes by Concanavalin k. PAAVO

TOIVANEN AND AULI TOIVANEN ...... 1602 Relationship between Graft-vs-Host Reactivity and Possession of the High Leu- kemia Genotype hr/hr. VALERIEA. I'ANsoN AND DAVID L. GASSER...... 1604 Tissue Typing: An Experimental Solution in the Chicken. MORTEN SIMONSEN.... 1607 Characterization of Glass-Adherent Human Mononuclear Cells. CHARLES A. KOLLER, GERALD W. KING, PAUL E. HURTUBISE, ARTHUR L. SAGONE~ AND ALBERT F. LoBuGLIO ...... 1610 Change in Susceptibility of C3H/HeJ Mice to LCM Virus Infection. MICHAELB. A. OLDSTONE AND FRANK J. DIXON...... 1613 Intercellular Communication in Stimulated Human Lymphocytes. GILBERTOM. OLIVEIRA-CASTRO, MARCELLO A. BARCINSKI AND SAMUEL CUKIERMAN ...... 1616