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Alfred Nobel
www.bibalex.org/bioalex2004conf The BioVisionAlexandria 2004 Conference Newsletter November 2003 Volume 1, Issue 2 BioVisionAlexandria ALFRED NOBEL 2004 aims to celebrate the The inventor, the industrialist outstanding scientists and scholars, in a he Nobel Prize is one of the highest distinctions recognized, granting its winner century dominated by instant fame. However, many do not know the interesting history and background technological and T that led to this award. scientific revolutions, through its It all began with a chemist, known as Alfred Nobel, born in Stockholm, Sweden in 1833. Nobel Day on 3 April Alfred Nobel moved to Russia when he was eight, where his father, Immanuel Nobel, 2004! started a successful mechanical workshop. He provided equipment for the Russian Army and designed naval mines, which effectively prevented the British Royal Navy from moving within firing range of St. Petersburg during the Crimean War. Immanuel Nobel was also a pioneer in the manufacture of arms, and in designing steam engines. INSIDE Scientific awards .........3 Immanuel’s success enabled him to Alfred met Ascanio Sobrero, the Italian Confirmed laureates ....4 Lady laureates ............7 provide his four sons with an excellent chemist who had invented Nitroglycerine education in natural sciences, languages three years earlier. Nitroglycerine, a and literature. Alfred, at an early age, highly explosive liquid, was produced by acquired extensive literary knowledge, mixing glycerine with sulfuric and nitric mastering many foreign languages. His acid. It was an invention that triggered a Nobel Day is interest in science, especially chemistry, fascination in the young scientist for many dedicated to many of was also apparent. -
書 名 等 発行年 出版社 受賞年 備考 N1 Ueber Das Zustandekommen Der
書 名 等 発行年 出版社 受賞年 備考 Ueber das Zustandekommen der Diphtherie-immunitat und der Tetanus-Immunitat bei thieren / Emil Adolf N1 1890 Georg thieme 1901 von Behring N2 Diphtherie und tetanus immunitaet / Emil Adolf von Behring und Kitasato 19-- [Akitomo Matsuki] 1901 Malarial fever its cause, prevention and treatment containing full details for the use of travellers, University press of N3 1902 1902 sportsmen, soldiers, and residents in malarious places / by Ronald Ross liverpool Ueber die Anwendung von concentrirten chemischen Lichtstrahlen in der Medicin / von Prof. Dr. Niels N4 1899 F.C.W.Vogel 1903 Ryberg Finsen Mit 4 Abbildungen und 2 Tafeln Twenty-five years of objective study of the higher nervous activity (behaviour) of animals / Ivan N5 Petrovitch Pavlov ; translated and edited by W. Horsley Gantt ; with the collaboration of G. Volborth ; and c1928 International Publishing 1904 an introduction by Walter B. Cannon Conditioned reflexes : an investigation of the physiological activity of the cerebral cortex / by Ivan Oxford University N6 1927 1904 Petrovitch Pavlov ; translated and edited by G.V. Anrep Press N7 Die Ätiologie und die Bekämpfung der Tuberkulose / Robert Koch ; eingeleitet von M. Kirchner 1912 J.A.Barth 1905 N8 Neue Darstellung vom histologischen Bau des Centralnervensystems / von Santiago Ramón y Cajal 1893 Veit 1906 Traité des fiévres palustres : avec la description des microbes du paludisme / par Charles Louis Alphonse N9 1884 Octave Doin 1907 Laveran N10 Embryologie des Scorpions / von Ilya Ilyich Mechnikov 1870 Wilhelm Engelmann 1908 Immunität bei Infektionskrankheiten / Ilya Ilyich Mechnikov ; einzig autorisierte übersetzung von Julius N11 1902 Gustav Fischer 1908 Meyer Die experimentelle Chemotherapie der Spirillosen : Syphilis, Rückfallfieber, Hühnerspirillose, Frambösie / N12 1910 J.Springer 1908 von Paul Ehrlich und S. -
Biochemistrystanford00kornrich.Pdf
University of California Berkeley Regional Oral History Office University of California The Bancroft Library Berkeley, California Program in the History of the Biosciences and Biotechnology Arthur Kornberg, M.D. BIOCHEMISTRY AT STANFORD, BIOTECHNOLOGY AT DNAX With an Introduction by Joshua Lederberg Interviews Conducted by Sally Smith Hughes, Ph.D. in 1997 Copyright 1998 by The Regents of the University of California Since 1954 the Regional Oral History Office has been interviewing leading participants in or well-placed witnesses to major events in the development of Northern California, the West, and the Nation. Oral history is a method of collecting historical information through tape-recorded interviews between a narrator with firsthand knowledge of historically significant events and a well- informed interviewer, with the goal of preserving substantive additions to the historical record. The tape recording is transcribed, lightly edited for continuity and clarity, and reviewed by the interviewee. The corrected manuscript is indexed, bound with photographs and illustrative materials, and placed in The Bancroft Library at the University of California, Berkeley, and in other research collections for scholarly use. Because it is primary material, oral history is not intended to present the final, verified, or complete narrative of events. It is a spoken account, offered by the interviewee in response to questioning, and as such it is reflective, partisan, deeply involved, and irreplaceable. ************************************ All uses of this manuscript are covered by a legal agreement between The Regents of the University of California and Arthur Kornberg, M.D., dated June 18, 1997. The manuscript is thereby made available for research purposes. All literary rights in the manuscript, including the right to publish, are reserved to The Bancroft Library of the University of California, Berkeley. -
Lecture Program
EARL W. SUTHERLAND LECTURE EARL W. SUTHERLAND LECTURE The Earl W. Sutherland Lecture Series was established by the SPONSORED BY: Department of Molecular Physiology and Biophysics in 1997 DEPARTMENT OF MOLECULAR PHYSIOLOGY AND BIOPHYSICS to honor Dr. Sutherland, a former member of this department and winner of the 1971 Nobel Prize in Physiology or Medicine. This series highlights important advances in cell signaling. ROBERT J. LEFKOWITZ, MD NOBEL PRIZE IN CHEMISTRY, 2012 SPEAKERS IN THIS SERIES HAVE INCLUDED: SEVEN TRANSMEMBRANE RECEPTORS Edmond H. Fischer (1997) Alfred G. Gilman (1999) Ferid Murad (2001) Louis J. Ignarro (2003) MARCH 31, 2016 Paul Greengard (2007) 4:00 P.M. 208 LIGHT HALL Eric Kandel (2009) Roger Tsien (2011) Michael S. Brown (2013) 867-2923-Institution-Discovery Lecture Series-Lefkowitz-BK-CH.indd 1 3/11/16 9:39 AM EARL W. SUTHERLAND, 1915-1974 ROBERT J. LEFKOWITZ, MD JAMES B. DUKE PROFESSOR, Earl W. Sutherland grew up in Burlingame, Kansas, a small farming community DUKE UNIVERSITY MEDICAL CENTER that nourished his love for the outdoors and fishing, which he retained throughout INVESTIGATOR, HOWARD HUGHES MEDICAL INSTITUTE his life. He graduated from Washburn College in 1937 and then received his MEMBER, NATIONAL ACADEMY OF SCIENCES M.D. from Washington University School of Medicine in 1942. After serving as a MEMBER, INSTITUTE OF MEDICINE medical officer during World War II, he returned to Washington University to train NOBEL PRIZE IN CHEMISTRY, 2012 with Carl and Gerty Cori. During those years he was influenced by his interactions with such eminent scientists as Louis Leloir, Herman Kalckar, Severo Ochoa, Arthur Kornberg, Christian deDuve, Sidney Colowick, Edwin Krebs, Theodore Robert J. -
Moore Noller
2002 Ada Doisy Lectures Ada Doisy Lecturers 2003 in BIOCHEMISTRY Sponsored by the Department of Biochemistry • University of Illinois at Urbana-Champaign Dr. Peter B. 1970-71 Charles Huggins* and Elwood V. Jensen A76 1972-73 Paul Berg* and Walter Gilbert* Moore 1973-74 Saul Roseman and Bruce Ames Department of Molecular carbonyl Biophysics & Biochemistry Phe 1974-75 Arthur Kornberg* and Osamu Hayaishi Yale University C75 1976-77 Luis F. Leloir* New Haven, Connecticutt 1977-78 Albert L. Lehninger and Efraim Racker 2' OH attacking 1978-79 Donald D. Brown and Herbert Boyer amino N3 Tyr 1979-80 Charles Yanofsky A76 4:00 p.m. A2486 1980-81 Leroy E. Hood Thursday, May 1, 2003 (2491) 1983-84 Joseph L. Goldstein* and Michael S. Brown* Medical Sciences Auditorium 1984-85 Joan Steitz and Phillip Sharp* Structure and Function in 1985-86 Stephen J. Benkovic and Jeremy R. Knowles the Large Ribosomal Subunit 1986-87 Tom Maniatis and Mark Ptashne 1988-89 J. Michael Bishop* and Harold E. Varmus* 1989-90 Kurt Wüthrich Dr. Harry F. 1990-91 Edmond H. Fischer* and Edwin G. Krebs* 1993-94 Bert W. O’Malley Noller 1994-95 Earl W. Davie and John W. Suttie Director, Center for Molecular Biology of RNA 1995-96 Richard J. Roberts* University of California, Santa Cruz 1996-97 Ronald M. Evans Santa Cruz, California 1998-99 Elizabeth H. Blackburn 1999-2000 Carl R. Woese and Norman R. Pace 2000-01 Willem P. C. Stemmer and Ronald W. Davis 2001-02 Janos K. Lanyi and Sir John E. Walker* 12:00 noon 2002-03 Peter B. -
Happy Birthday to Renato Dulbecco, Cancer Researcher Extraordinaire
pbs.org http://www.pbs.org/newshour/updates/happy-birthday-renato-dulbecco-cancer-researcher-extraordinaire/ Happy birthday to Renato Dulbecco, cancer researcher extraordinaire Photo of Renato Dulbecco (public domain) Every elementary school student knows that Feb. 22 is George Washington’s birthday. Far fewer (if any) know that it is also the birthday of the Nobel Prize-winning scientist Renato Dulbecco. While not the father of his country — he was born in Italy and immigrated to the United States in 1947 — Renato Dulbecco is credited with playing a crucial role in our understanding of oncoviruses, a class of viruses that cause cancer when they infect animal cells. Dulbecco was born in Catanzaro, the capital of the Calabria region of Italy. Early in his childhood, after his father was drafted into the army during World War I, his family moved to northern Italy (first Cuneo, then Turin, and thence to Liguria). A bright boy, young Renato whizzed through high school and graduated in 1930 at the age of 16. From there, he attended the University of Turin, where he studied mathematics, physics, and ultimately medicine. Dulbecco found biology far more fascinating than the actual practice of medicine. As a result, he studied under the famed anatomist, Giuseppe Levi, and graduated at age 22 in 1936 at the top of his class with a degree in morbid anatomy and pathology (in essence, the study of disease). Soon after receiving his diploma, Dr. Dulbecco was inducted into the Italian army as a medical officer. Although he completed his military tour of duty by 1938, he was called back in 1940 when Italy entered World War II. -
Arthur Kornberg Discovered (The First) DNA Polymerase Four
Arthur Kornberg discovered (the first) DNA polymerase Using an “in vitro” system for DNA polymerase activity: 1. Grow E. coli 2. Break open cells 3. Prepare soluble extract 4. Fractionate extract to resolve different proteins from each other; repeat; repeat 5. Search for DNA polymerase activity using an biochemical assay: incorporate radioactive building blocks into DNA chains Four requirements of DNA-templated (DNA-dependent) DNA polymerases • single-stranded template • deoxyribonucleotides with 5’ triphosphate (dNTPs) • magnesium ions • annealed primer with 3’ OH Synthesis ONLY occurs in the 5’-3’ direction Fig 4-1 E. coli DNA polymerase I 5’-3’ polymerase activity Primer has a 3’-OH Incoming dNTP has a 5’ triphosphate Pyrophosphate (PP) is lost when dNMP adds to the chain E. coli DNA polymerase I: 3 separable enzyme activities in 3 protein domains 5’-3’ polymerase + 3’-5’ exonuclease = Klenow fragment N C 5’-3’ exonuclease Fig 4-3 E. coli DNA polymerase I 3’-5’ exonuclease Opposite polarity compared to polymerase: polymerase activity must stop to allow 3’-5’ exonuclease activity No dNTP can be re-made in reversed 3’-5’ direction: dNMP released by hydrolysis of phosphodiester backboneFig 4-4 Proof-reading (editing) of misincorporated 3’ dNMP by the 3’-5’ exonuclease Fidelity is accuracy of template-cognate dNTP selection. It depends on the polymerase active site structure and the balance of competing polymerase and exonuclease activities. A mismatch disfavors extension and favors the exonuclease.Fig 4-5 Superimposed structure of the Klenow fragment of DNA pol I with two different DNAs “Fingers” “Thumb” “Palm” red/orange helix: 3’ in red is elongating blue/cyan helix: 3’ in blue is getting edited Fig 4-6 E. -
Earl W. Sutherland Lecture Earl W
EARL W. SUTHERLAND LECTURE EARL W. SUTHERLAND LECTURE The Earl W. Sutherland Lecture Series was established by the SPONSORED BY: Department of Molecular Physiology and Biophysics in 1997 DEPARTMENT OF MOLECULAR PHYSIOLOGY AND BIOPHYSICS to honor Dr. Sutherland, a former member of this department and winner of the 1971 Nobel Prize in Physiology or Medicine. This series highlights important advances in cell signaling. MICHAEL S. BROWN, M.D NOBEL LAUREATE IN PHYSIOLOGY OR MEDICINE 1985 SPEAKERS IN THIS SERIES HAVE INCLUDED: SCAP: ANATOMY OF A MEMBRANE STEROL SENSOR Edmond H. Fischer (1997) Alfred G. Gilman (1999) Ferid Murad (2001) Louis J. Ignarro (2003) APRIL 25, 2013 Paul Greengard (2007) 4:00 P.M. 208 LIGHT HALL Eric Kandel (2009) Roger Tsien (2011) FOR MORE INFORMATION, CONTACT: Department of Molecular Physiology & Biophysics 738 Ann and Roscoe Robinson Medical Research Building Vanderbilt University Medical Center Nashville, TN 37232-0615 Tel 615.322.7001 [email protected] EARL W. SUTHERLAND, 1915-1974 MICHAEL S. BROWN, M.D. REGENTAL PROFESSOR Earl W. Sutherland grew up in Burlingame, Kansas, a small farming community that nourished his love for the outdoors and fishing, which he retained throughout DIRECTOR OF THE JONSSON CENTER FOR MOLECULAR GENETICS UNIVERSITY OF TEXAS his life. He graduated from Washburn College in 1937 and then received his M.D. SOUTHWESTERN MEDICAL CENTER AT DALLAS from Washington University School of Medicine in 1942. After serving as a medi- NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE, 1985 cal officer during World War II, he returned to Washington University to train with MEMBER, NATIONAL ACADEMY OF SCIENCES Carl and Gerty Cori. -
Download Ps Nobel Prizes for Site BEE 11.18.16 Revised 11.30.17.Pdf
Nobel Laureates at the College of Physicians and Surgeons For years, College of Physicians and Surgeons alumni, faculty, and researchers have led groundbreaking clinical and basic scientific studies that have transformed our understanding of human biology and advanced the practice of medicine. On many occasions, this work has been honored with the Nobel Prize. The scope of research led by P&S Nobel laureates is tremendous. Although most of our prizewinners were honored for work in physiology or medicine, a few also received the prize for chemistry. Their research has fundamentally shaped the course of numerous fields, including cardiology, neuroscience, genetics, pharmaceutical development, and more. Our Nobel laureates include: André Cournand and Dickinson Richards (P&S’23), whose work at P&S on cardiac catheterization—a method of inserting a tiny tube into the heart—provided the basis for open-heart surgery and interventional cardiology Baruch Blumberg (P&S’51), who discovered the hepatitis B virus and helped develop a test and a vaccine for the virus Joshua Lederberg, a Columbia College and P&S graduate student who showed that bacteria can exchange genes when they reproduce, creating a way to model and study genetics in higher organisms Harold Varmus (P&S’66), who demonstrated how genes in normal human and animal cells can mutate to cause cancer, leading to a new generation of research on the genetic origins of cancer Eric Kandel, current University Professor, who showed how memories are stored in nerve cells, greatly enhancing -
Obituary: Professor Arturo Falaschi the Human Frontier Science
Obituary: Professor Arturo Falaschi The Human Frontier Science Program Organization is greatly saddened by the sudden death of Prof. Arturo Falaschi on June 1st 2010. Arturo was a member of the HFSP Council of Scientists from 1996-2001, serving as Chair of the Council for two years from 2000-2001. This was a time of great change for HFSP following the appointment of Torsten Wiesel as Secretary General and the introduction of many program initiatives. Arturo led the discussions at the Council of Scientists with great energy and imagination. He contributed substantially to the transformation of HFSP that occurred during this period, being instrumental in the reorganization of the scientific programs by championing the merging of the traditional neuroscience and molecular biology committees. Arturo Falaschi had a distinguished scientific career in the field of DNA replication. After postdoctoral training with Nobel Laureates Har Gobind Khorana in Wisconsin and Arthur Kornberg at Stanford, he returned to Italy to the Institute of Genetics of the CNR (the Italian National Research Council) at the University of Pavia, where he was later appointed as Director of the CNR Institute for Biochemical and Evolutionary Genetics and then Director of the CNR National Project for Genetic Engineering. In 1987 he became Head of the Trieste component of the International Centre for Genetic Engineering and Biotechnology (ICGEB). From 1989-2004 he was Director-General of the ICGEB and remained associated with the Centre as Head of the ICGEB Molecular Biology Laboratory in Pisa. He also served as a member of the Executive Committee of the CNR. Arturo had a strong commitment to the global scientific endeavour. -
A. Personal Statement I Have Been Studying the Regulation of Mast Cell Activation and Its Role in Neuroinflammatory Diseases for Over 30 Years
OMB No. 0925-0001 and 0925-0002 (Rev. 10/15 Approved Through 10/31/2018) BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FIVE PAGES. NAME POSITION TITLE THEOHARIDES, THEOHARIS C. Professor of Pharmacology and Internal Medicine (Allergy & Clinical Immunology) eRA COMMONS USR NAME (credential, e.g. agency login) THEOHAR EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) INSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY (if applicable) Yale University, New Haven, CT B.A. 1972 Biology & Hist. Medicine Yale University, New Haven, CT M.S. 1975 Neuroimmunology Yale University, New Haven, CT M.Phil. 1975 Immunopharmacology Yale University, New Haven, CT Ph.D.* 1978 Pharmacology Yale University, New Haven, CT M.D. 1983 Medicine Tufts University, Fletcher School Law & Diplomacy Certificate 1999 Leadership& Management Harvard Univ, J.F. Kennedy School of Government M.P.A. Deferred Biomedical Res Policy *Doctoral Thesis advisors: W.W. Douglas, M.D.-Royal Acad. Sciences; Paul Greengard, Ph.D.-2000 Nobel Laureate in Physiol & Med; Doctoral Thesis examiner, George E. Palade, M.D.- 1974 Nobel Laureate in Physiology& Medicine A. Personal Statement I have been studying the regulation of mast cell activation and its role in neuroinflammatory diseases for over 30 years. I was the first to report that mast cells can: (a) secrete specific mediators -
Cover June 2011
z NOBEL LAUREATES IN Qui DNA RESEARCH n u SANGRAM KESHARI LENKA & CHINMOYEE MAHARANA F 1. Who got the Nobel Prize in Physiology or Medicine 1933) for discovering the famous concept that says chromosomes carry genes? a. Gregor Johann Mendel b. Thomas Hunt Morgan c. Aristotle d. Charles Darwin 5. Name the Nobel laureate (1959) for his discovery of the mechanisms in the biological 2. The concept of Mutations synthesis of ribonucleic acid and are changes in genetic deoxyribonucleic acid? information” awarded him a. Arthur Kornberg b. Har Gobind Khorana the Nobel Prize in 1946: c. Roger D. Kornberg d. James D. Watson a. Hermann Muller b. M.F. Perutz c. James D. Watson 6. Discovery of the DNA double helix fetched them d. Har Gobind Khorana the Nobel Prize in Physiology or Medicine (1962). a. Francis Crick, James Watson, Rosalind Elsie Franklin b. Francis Crick, James Watson and Maurice Willkins c. James Watson, Maurice Willkins, Rosalind Elsie Franklin 3. Identify the discoverer and d. Maurice Willkins, Rosalind Elsie Franklin and Francis Crick Nobel laureate of 1958 who found DNA in bacteria and viruses. a. Louis Pasteur b. Alexander Fleming c. Joshua Lederberg d. Roger D. Kornberg 4. A direct link between genes and enzymatic reactions, known as the famous “one gene, one enzyme” hypothesis, was put forth by these 7. They developed the theory of genetic regulatory scientists who shared the Nobel Prize in mechanisms, showing how, on a molecular level, Physiology or Medicine, 1958. certain genes are activated and suppressed. Name a. George Wells Beadle and Edward Lawrie Tatum these famous Nobel laureates of 1965.