Newsletter May 2018

Silicon Valley Section American Chemical Society Volume 40 No. 5

MAY 2018 NEWSLETTER TOPICS 2017 Harry and Carol Mosher Award Recipient • 2017 Harry and Carol Mosher Award Dr. Nicola Pohl Recipient Dr. Nicola Pohl On March 15, the Silicon Valley section • Chair's Message awarded the 2017 Harry and Carol Mosher • Connect with Chemists Award to Dr. Nicola Pohl. Nicola Pohl is • 2018 Inductees into the National Professor of chemistry and the Joan and Inventors Hall of Fame (NIHF) Marvin Carmack Chair in Bioorganic • A Statement on our Mission Chemistry at Indiana University. She is cur- rently also a Fellow of the Radcliffe Institute • Attention Book Lovers of Advanced for Advanced Study at Harvard • The 255th National Meeting of the and a Visiting Professor at MIT. Her research American Chemical Society aims to understand and exploit the subtle dif- Down in New Orleans ferences amongst sugars in order to develop • Calling All Community College automated workflows to synthesize and ana- Dr. Nicola Pohl receiving the Mosher award Instructors! lyze carbohydrates and incorporate them into plaque presented by Natalie McClure, March • Call for Nominations Ottenberg Award biotherapeutics designs. 15, 2018 • ACS Webinars The carbohydrates attached to proteins/ multistep synthesis followed by careful analysis • Resources You Can Use antibodies and peptides significantly alter the to confirm the structure. The lack of a good biological properties of the parent structure. and easy synthesis scheme has prevented for- • New SVACS Members Chemical synthesis of glycopeptides and gly- mation of a library of the different hexoses • This Month in Chemical History coproteins for systematic structure/function which researchers can use as a tool. • Chemployment Abstracts relationships studies, however, is challenging. Dr. Pohl and her research group are • Chemistry Quiz In her presentation, Dr. Pohl discussed meth- developing new synthetic routes for the prepa- ods developed for solution-phase automated ration of carbohydrates, drawing on advances carbohydrate synthesis and current efforts to in robotic synthesis based on the approaches Connect with Chemists link the products of this synthesis platform initial identified by Merriweather for solid An early morning chat with fellow chemists with solid-phase peptide synthesis. phase peptide synthesis. Thursday, May 17, 2018, at 7 a.m. The challenges in Coupa Café, 538 Ramona Street, Palo Alto synthesizing and study- Contact Ean Warren ([email protected]) ing carbohydrates are for more information or ask for Ean at Coupa. illustrated in the figure. There are 16 different regio- and sterioisomers Chair's Message for a hexose, a six car- Melody Esfandiari bon sugar. Each of I hope you are these molecules welcoming spring requires a complex and enjoying the sea- son change. Many of you may be graduat- for our chapter. We felt it was beneficial to this newsletter, and we encourage you to write ing or attending a have a clear mission statement. This statement to us with your comments. graduation; best of can be used as a tool to guide us in using our Now for the next topic, I’d like to chat luck to those who resources in ways that are beneficial to the about a rather popular subject that has been are graduating! This month, the Executive science community and our local community. subject to much scrutiny since it’s perceived committee drafted a new mission statement You can find our revised mission statement in continued on next page Chair's Message, continued from front page every month, but I want to share more update A Statement as a mainstream hobby. Social media! I’m regarding our activities and most importantly part of the millennial generation and grew up get feedback (also known as “likes” in the so- on our SVACS Mission By Madalyn Radlauer in Cupertino minutes away from high tech cial media world). If you decide to join us, you companies, yet I always shunned away from can find our Facebook page @SiValleyACS Over our last two Executive Committee social media and never opened a Facebook ac- and Twitter account @ SiValleyACS meetings, we have discussed and compiled count until very recently. Many of our readers Lastly, I would like to wish all the input on the specific mission of the Silicon may have had the same philosophy regarding mothers a beautiful and happy Mother’s Valley ACS Section. Our most recent mission social media, so I wanted to share my thoughts Day. In the honor of Mother’s Day, for our statement was written in 2002 and we felt it with you. chair’s monthly fun fact, we wanted to have a was important to update this and craft a cur- Social media has grown tremendously relevant one. Growing up, my brother and I rent mission statement, one that would allow in the past decade. It’s hard to imagine that both had a serious sweet tooth! Of course, my us to evaluate our activities and programming 20 years ago, we had to call someone to talk mom had to constantly hide all the sweets in and be the best section we can be! To achieve to them or pass notes in class to someone the house and was not happy with us when we this, we decided to develop a living mission we liked instead of texting. A recent study would find her secret hiding places. But little statement that we could put up for revision showed that on average people check their did she know that our bad snacking habits each year based on comments from the execu- Facebook 13.8 times a day. That number blew were sort of her own fault. What women eat tive committee and our membership. We put my mind, but after giving it some thought I during pregnancy shapes the food preferences together and voted on an initial draft (see realized that Facebook doesn’t force us to log in of their children later in life. The growing baby below) and would greatly value any feedback constantly and overshare, the users make that swallows amniotic fluids, which are flavored you may have to help us shape this statement. decision. Social media can help us connect, by the foods the mother consumes. Research We would also love to hear if you approve of raise awareness, and build communities. I has shown that the kind of food a fetus intakes this mission statement. Please send your feed- have concluded that proper use of social media from amniotic fluid influences their dietary back to Madalyn Radlauer (madalyn.radlau- outweighs the cons. When I became the chair, preferences later in life. So if you want your [email protected]) by June 1st and she will compile I felt that I wanted to reach out to our mem- children to love vegetables and fruits, you need it for the executive committee meeting on bers more, share updates and get feedback, to start before they are born and have a diet June 6th when the adoption of the mission and social media makes that possible. That is with high concentration of veggies and low statement will be brought to an official vote. key! It’s wonderful to write a message to you sweets. But it is hard to resist sweets! Initial Draft of SVACS Mission Statement: 2018 Inductees into the National Inventors The mission of the National American Chemical Society is “Advancing the broader Hall of Fame (NIHF) chemistry enterprise and its practitioners for the By Howard Peters benefit of Earth and its people.” Since 1973, the National Inventors Hall of Fame (NIHF) has inducted selected inventors To that end, we, the Silicon Valley Section, holding US patents who have contributed significantly to the US and world economies. The define our mission to be “Engaging the chemistry next induction will occur May 4, 2018 in Washington DC. More information is available at the community by providing professional develop- http://www.invent.org URL: . The selected inventors and patent numbers are listed below. ment, educational opportunities, networking, www.pat2pdf.org www.uspto.gov Copies of the U.S. patents listed below can be found at or . and recognition; and by sharing innovative, U.S. Patent No. Inventor(s) Technology Area exciting, and fun chemistry with our diverse 4,405,829 Leonard Adleman RSA Cryptography broader community through education and out- 4,415,732 & 4,458,066 Marvin Caruthers Chemical Synthesis of DNA reach.” 281,884 & 542,733 Warren S. Johnson Temperature Control 4,010,470 Howard S. Jones, Jr. Conformal Antennas 6,141,060 Stan Honey Sports Broadcast Graphic Enhancements Attention Book Lovers! 6,387,981 & 6,572,693 Sumita Mitra Nanocomposite Dental Materials The next meeting of the Silicon Valley 1,996,171 Mary Engle Pennington Food Preservation and Storage ACS Science Book group will be held on Saturday, May 12 at 2 p.m. in the Stanford 6,664,298 Jacqueline Quinn EZVI (Emulsified Zero-Valent Iron) Chemistry Gazebo. We will meet for a discus- 3,023,192 Joseph C. Shivers, Jr. LYCRA® Fiber (Spandex) sion of the book “The Poisoner’s Handbook. 5,345,599 Arogyaswam i Paulraj MIMO Wireless Technology Murder and the Birth of Forensic Medicine in 4,405,829 Adi Shamir SA Cryptography the Jazz Age, New York” by Deborah Blum. 4,405,829 Ronald Rivest RSA Cryptography This is an easy, light read and describes the 4,599,315 Paul Terasaki Typing for Organ Transplants state of medicine, law enforcement and chem- 4,356,429 Ching Wan Tang Organic Light-Emitting Diode (OLED) istry analytical forensic techniques during the 4,539,507 Steven Van Slyke Organic Light-Emitting Diode (OLED) Prohibition times. Everyone is welcome to join Note how many of these inventions are chemistry-related. This is the highest proportion of our discussions. For more information, see chemistry inventors inducted in several years. http://scvacs.org/?page_id=1337. The 255th National Meeting of the American Chemical Society Down in New Orleans The perspective of Madalyn Radlauer, one of your SVACS alternate councilors Starting around March 17th over 16,000 Plans had changed for one of our councilors As usual, the ACS meeting was filled with members of the chemistry community gath- and I would get to join the other section rep- exciting science, (unexpected) reunions, and ered in “that city way down on the river.” resentatives at the councilor meeting on good times. I especially loved having the Being originally from New Orleans, I was Wednesday. Exciting news for your newest meeting in my hometown and maybe, for a thrilled with the opportunity to hear amazing alternate councilor! short while at least, my fellow councilors will science in my hometown. Monday, I walked in the opposite direc- “know what it means to miss New Orleans” In last month’s newsletter Howard and tion, going from the INOR plenary session at right along with me. Matt covered the talking points of the the Convention Center in the morning to Councilor’s meeting on the Wednesday of the PMSE at the Marriott in the afternoon with v v v meeting, so this month it is my pleasure to lunch in between at Lucy’s Retired Surfers Bar share with you my experiences leading up to & Restaurant (great fried shrimp!). Towards Calling All Community the councilor meeting. In the past, I have the end of the PMSE session, I gave my talk found that there are always too many good on block polymers. Monday evening was a College Instructors! talks at a national ACS meeting to make it to special treat: my parents hosted a crawfish boil I would like to invite you to nominate them all and this one was no exception. I for my friends and colleagues in uptown. We a deserving teacher-scientist for the Teacher belong to both INOR and POLY and was cajoled and peeled pounds upon pounds of Scholar Award. giving a talk in PMSE. Not only that, one of boiled crawfish with potatoes, corn, and The ACS Teacher Scholar Award, estab- my fellow professors from San José State Zapp’s chips. lished in 2008 by the Silicon Valley section of University, Joe Pesek, was receiving the ACS Tuesday morning, I went back for more the American Chemical Society, recognizes the contributions of Community College faculty Award for Research at an Undergraduate INOR talks featuring two Bay Area profes- to science and education. The award consists Institution! It promised to be a busy week. sors, Ken Raymond of UC Berkeley (talking of an ACS plaque and a check for $500 for Sunday morning, I dressed in my profes- about energy transfer in lanthanide complex- the awardee, with another $500 check being sional best and headed to the New Orleans es) and Dan Stack from Stanford University donated to the awardee’s college chemistry Marriott on Canal Street where all the POLY (presenting on his simple imidazole ligands for department. and PMSE sessions were held. All morning I CuIII2O2 complexes). Before getting over to The nomination form and more infor- enjoyed polymer science talks including one POLY/PMSE, I stopped in at The Ruby mation regarding the award and the nomina- on selective acyclic diene metathesis by SJSU Slipper for shrimp and grits, setting myself up tion process can be found here. The deadline professor Chester Simocko and one by Joe for an afternoon of self-assembling materials. for submission is June 30th 2018. DeSimone CEO and co-founder of Carbon, Tuesday night was the big awards ban- If you have any questions please don’t a Bay Area-based company that uses polymer quet back at the New Orleans Marriott where hesitate to contact me directly at science to enable their cutting-edge rapid 3-D several Bay Area professionals were honored [email protected]. printing tech. for their achievements. In addition to Joe Slava Bekker, Chair Around noon, I made the roughly 1-mile Pesek’s award, Hairong Zhou (Genentech) SVACS Teacher-Scholar Award Committee walk to the Convention Center where the was acknowledged as part of the ACS Award Chemistry Instructor, Hartnell College majority of the sessions as well as the for Team Innovation, Richard Saykally (UC Exposition were being held. Once in the Berkeley) received the E. Bright Wilson v v v Convention Center, I couldn’t seem to blink Award in Spectroscopy, William Degrado without running into someone that I had met (UCSF) was recognized as an Arthur C. Cope Call for Nominations before from college, graduate school, my post- Scholar, and Stacey Bent (Stanford) was pre- Ottenberg Award doc, or from previous meetings or conferenc- sented with the ACS Award in Surface es. I enjoyed a bowl of crawfish étouffée for Chemistry. To finish off the lovely evening The Ottenberg Award is presented an- nually to a member of our local section for lunch while chatting with acquaintances from celebrating the accomplishments of these and outstanding service to the section. Previous Dow and then nearly ran into a friend from many others, Geraldine Richmond of the recipients are not eligible to receive it again. the University of Minnesota as I hurried to University of Oregon was awarded the Nominations should include the nominee's bi- the next talk. The afternoon was filled with Priestley Medal – the highest honor the ACS ography, description of the service(s) for which inorganic catalysis and square schemes to ana- bestows – “for her pioneering contributions to the member is nominated, and a discussion lyze thermochemical data. our understanding of the molecular properties or evaluation of the service to be recognized Sunday evening, a reception was hosted of liquid surfaces and her extraordinary service by the award. Please send your nomination to by Research Corporation in honor of Joe to chemistry on a global level.” [email protected] or by fax (650-961-8120) Pesek’s award. Coming out of the reception, I After the council meeting on Wednesday before June 15, 2018. ran into my fellow SVACS members includ- morning and a few more talks in the after- ing ACS President-Elect Bonnie Charpentier. noon, I headed back to San Jose on Thursday. v v v ACS Webinars Preview the ACS Webinars archive https://www.acs.org/content/acs/en/acs-webinars.html?cid=home_4up by viewing these three, open recordings.

Reshaping Chemical Lab Safety: Creating a Exceptional Presentations In Spite of Sexual Harassment in the Sciences: Steps Dynamic and Adaptive Safety Environment PowerPoint: How to Communicate in the Forward What You Will Learn Digital Age What You Will Learn • A 21st century strategic direction that you What You Will Learn • What is sexual harassment. can implement to support laboratory • How and why you must identify your • Why sexual harassment is prevalent in chemical safety for both academics and target audience to deliver impactful science. industry. presentation. • How to address sexual harassment in your • Recent documents that achieve a spiral • What are the limitations when presenting to science workplace. approach to chemical safety education. faceless audiences that are miles away. • Invaluable tools and resources for chemical • How to overcome virtual audience limita- safety planning in all lab environments. tions with learnable skills.

Resources You Can Use Information’s PubChem database.” IR, Raman, UV-Vis, and mass spectra by Dimensions Source: https://www.epa.gov/chemical- chemical name, synonym, CAS Registry https://app.dimensions.ai/discover/publication research/chemistry-dashboard Number, or InChIKey. Users can zoom in “Digital Science has launched SpectraBase on the spectra and upload and overlay their Dimensions, a ground-breaking research https://spectrabase.com own spectrum for comparison. Bio-Rad information platform that enables users to “Available at https://spectrabase.com and encourages their use in presentations and explore over 4 billion connections between with hundreds of thousands of free spectra publications (with proper citation, of course). 128 million publications, grants, patents, data available, Bio-Rad's SpectraBase is an excellent Free access but registration required.” and metrics for the first time, with free search resource for those wanting to look up NMR, (publisher’s description) and citation data across 89 million articles.” (publisher’s description). The Winter 2018 issue of Issues in Science and Technology Welcome to the Silicon Valley Section of ACS Librarianship contains a review of the Each month, the section receives a spreadsheet from national ACS with the names of Dimensions database. members new to our section. The members are either new to ACS, have transferred in from other areas, or are the newest members -- students. To welcome you to the section and get to CompTox Chemistry Dashboard know you, the Executive Committee offers new members a free dinner! To encourage you to https://comptox.epa.gov/dashboard attend a monthly section seminar meeting, we would like you to be our guest. When you “The Chemistry Dashboard is part of a register, make certain to mention that you are a new member and you and a friend will be our suite of dashboards developed by EPA to help guests. The seminar meetings are held at a number of local venues. If you are unable to attend evaluate the safety of chemicals. The Chemistry inthe evening, perhaps you would join us for an outreach event, like judging a science fair, Dashboard provides access to a variety of proctoring the Chemistry Olympiad or participating in a National Chemistry Week event in information on over 700,000 chemicals October. Then, there is our annual wine tasting and awards picnic in July. The local section is currently in use. Within the Chemistry a volunteer organization. Please attend an event, volunteer to help and get to know your local Dashboard, users can access chemical struc- fellow chemists. Welcome! tures, experimental and predicted physico- chemical and toxicity data, and additional New SVACS Members links to relevant websites and applications. Dr. Nicholas Borrero Daniel Holycross Marita E. Ocampo It maps curated physicochemical property Dr. David A. Britz Tianyi Kou Justin Poelma data associated with chemical substances to Trevor Alexander Cabreros Roberto Ladino Kaitlyn Ramirez their corresponding chemical structures. These Cassandra Elizabeth Callmann Rebecca Lennen Ramandeep Rekhi data are compiled from sources including the David Cate Yayuan Liu Edward Prinz Schreiner EPA’s computational toxicology research data- Bruce Clemens Helen Claire Maschino James Alfred Winston Shoemaker bases, and public domain databases such as Dr. Kanad Das Michael Robert Mish Peter Martin Vanderpool the National Center for Biotechnology Maria del Carmen Duran Atia Naim Deborah Wang This Month in Chemical History May 1 research on chlorine and alkali metals. of solutions; discovered that vapor pressure • Hilaire Bernigaud de Chardonnet born 1839: • Sigurd Varian born 1901: with brother Rus- in many solutions is proportional to the invented rayon by forcing liquid nitrocel- sell, invented klystron tube and founded number of molecules per unit volume in lulose through fine glass capillaries. Varian instruments. the solution (Raoult's law); freezing-point • Alexander William Williamson born 1824: May 5 depression; vapor pressure lowering. alcohols and ethers (synthesis of ethers, • Proctor and Gamble incorporated, 1905. May 11 with important consequences in organic May 6 • Donald Othmer born 1904: chemi- structure theory); suggested the notion that • Victor Grignard born 1871: developed cal engineer; co-founder and editor of catalysis can proceed through intermediate magnesium-based reagent (Grignard Kirk-Othmer Encyclopedia of Chemical compounds; synthesis of ethylene glycol. reagent) used in organic synthesis; Nobel Technology. May 2 Prize, 1912. May 12 • BF Goodrich incorporated, 1912. • Paul Christian Lauterbur born 1926: • Dorothy Crowfoot Hodgkin born 1910: X- • William Nicholson placed wires connected to magnetic resonance imaging (MRI), an ray determination of Vitamin B12 crystal a battery in water, observing its electrolysis, application of nuclear magnetic resonance structure; Nobel Prize, 1964. 1800. (NMR) to medical imaging (see original Justus Liebig born 1803: "Father of agri- May 3 paper); Nobel Prize (Medicine), 2003. cultural chemistry"; quantitative organic • George Paget Thomson born 1892: electron • Richard Moore born 1871: advocated helium analysis; Liebig condenser; distinguished diffraction; Nobel Prize (physics), 1937. It for balloons and dirigibles; supervised fats, protins, and carbohydrates in foods. has been noted that G. P. Thomson helped production of radium salts in US. May 13 show that the electron is a wave while his May 8 • Marie Curie was appointed professor of father, J. J. Thomson, helped show that it • Antoine Lavoisier was sentenced to death by physics at the Sorbonne, 1906 (the first is a particle. the French Revolutionary Tribunal and woman professor there). May 4 executed by guillotine, 1794. May 14 • Louis-Jacques Thénard born 1777: discovered May 9 • George Fownes born 1815: organic and sodium peroxide, potassium peroxide, and • Henry Gilman born 1893: organometallic analytical chemistry; author of Elementary hydrogen peroxide; Thenard's blue (used in chemistry. Chemistry: Theoretical and Practical, coloring porcelain); showed that caustic soda May 10 which went through many editions long and potash contain hydrogen and oxygen; • François-Marie Raoult born 1830: properties after Fownes' death.

CHEMPLOYMENT ABSTRACTS MAY 2018

CHEMPLOYMENT ABSTRACT 4004 Position Title: Senior Production Chemist – Silica Manufacturing Job Description: The Senior Production Chemist is responsible for conducting pro- duction activities for silica based separation media and related intermediates. Chemistry Quiz QUALIFICATIONS DESIRED: Education: PhD in Organic Synthetic Chemistry preferred, but will consider Bachelor’s in What is the common trivial name of n-hexanoic acid Chemistry with 8 years of synthetic chemistry experience. Experience: Deep knowledge and experience in analysis of grafting and surface modifi- (CH3(CH2)4COOH)? What is the basis for this cation of polymeric materials required. Must have strong background in synthetic name? organic chemistry. LOCATION, SALARY, EMPLOYER: The answer will appear in next month’s newsletter. Job Location: Sunnyvale, CA Last Month's Chemistry Quiz Salary: Commensurate with experience Description: Thermo Fisher Scientific is the world leader in serving science. Our mission Who has won the Nobel prize in Chemistry twice? is to enable our customers to make the world healthier, cleaner and safer, with revenues of $13 billion. Frederick Sanger in 1958 for his work on the struc- Application Instructions: Please apply online at www.thermofisher.com/careers - ture of proteins, and in 1980 for his contributions jobcode: 63797BR concerning the determination of base sequences in nucleic acids

The Silicon Valley Section of the American Chemical Society is the copyright owner of all material published in The Silicon Valley Chemist. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without advance permission in writing from the editor, particularly for commercial purposes. Authorization to photocopy items for limited internal or personal use, or the limited internal or personal use of specific clients, is granted by the Executive Committee of the Silicon Valley Section of the American Chemical Society. SILICON VALLEY SECTION AMERICAN CHEMICAL SOCIETY P.O. Box 395, Palo Alto, CA 94302

To receive an email when our newsletter is published on our web site, sign up at: http://scvacs.org/?page_id=99

SILICON VALLEY SECTION FUTURE EVENTS 2018 Section Officers Chair Melody Esfandiari 408-924-4973 [email protected] May 12 Stanford’s Jasper Ridge Biological Preserve: Chair-Elect Grace Baysinger 650-725-1039 [email protected] Community Open House Past Chair Todd Eberspacher 650-723-2505 [email protected] https://www6.slac.stanford.edu/community/public-tours Secretary Jigisha Shah 315-289-5115 [email protected] May 12 Silicon Valley ACS Section Book Club Treasurer Ihab Darwish 650-624-1389 [email protected] Stanford Chemistry Gazebo - 2 p.m. http://scvacs.org/?page_id=1337 Councilors 2016-2018 Linda Brunauer 408-554-6947 [email protected] May 19 Hayward Fault 150th Anniversary of Great 2016-2018 Sally Peters 650-447-3027 [email protected] Quake Tour Tule Ponds 2018-2018 Peter Rusch 650-961-8120 [email protected] 1999 Walnut Avenue, Fremont, CA 2017-2019 George Lechner 408-226-7262 [email protected] http://msnucleus.org/haywardfault/150_hayward.html 2017-2019 Matt Greaney 510-410-0195 [email protected] Jun 18-20 Green Chemistry and Engineering 2018-2020 Ean Warren 650-329-4554 [email protected] Conference 2018-2020 Natalie McClure 650-906-7831 [email protected] Portland, OR Alternate Councilors http://www.gcande.org/?cid=home_meetings 2018-2018 Alex Klevay 408-561-0087 [email protected] Jun 21 SVACS Joint Meeting with the Golden Gate 2018-2018 Richard Bone 650-714-7897 [email protected] Polymer Forum 2018-2018 Howard Peters 650-447-3027 [email protected] Dr. Robert Grubbs, speaker 2017-2019 Elizabeth Migicovski 408-924-5012 [email protected] Michael’s at Shoreline Park 2017-2019 Slava Bekker 831-759-6005 [email protected] http://michaelsatshoreline.com/ 2018-2020 Madalyn Radlauer 408-924-5482 [email protected] Mountain View, CA 2018-2020 Jane Frommer 408-927-2225 [email protected] Jul 14 Silicon Valley ACS Section Annual Awards Presentation and Picnic Newsletter Stanford, Chemistry Department Editor Kevin Greenman 408-634-2309 [email protected] Stanford, CA Assoc. Editor Partha P. Bera [email protected] Click on links for more information or ChemPloyment Abstracts see this newsletter at http://scvacs.org/?page_id=99 Director: Liang Cao [email protected]