Clinical and Pathological Reports

802 Cancer Research

Conn.] THE PARTICIPATION OF THE ANTERIOR CHAM- essentially of somewhat atypical tissue or histogenous mast BER OF THE EYE IN RESISTANCE PHENOMENA RE- cells with cytoplasm containing numerous metachromatic LATED TO TUMOR GROWTH. Cancer Research, ~:669-675. 1942. basophilic granules. Three of the tumors were solitary A series of experiments was performed in an attempt and benign and 2 were multiple and apparently malig- to ascertain whether or not a blood-aqueous humor nant. With only 4 possible exceptiong no neoplasms of a barrier separated the anterior chamber of the eye from the similar type have been reported in the human or veterinary remainder of the body, and thus determined the ease literature. The cytoplasm of the neoplastic mast cells con- with which tumor transplantation was effected at this tains, in addition to the metachromatic basophilic granules, site. It was found that, following tumor growth in the rod-shaped crystalloids, spherical basophilic bodies of solid anterior chamber of one eye, both the testicle and the or granular structure, and spherical acidophilic bodies. anterior chamber of the opposite side were resistant to --H. G. W. reinoculation. On this basis it was concluded that the STEINER, P. E., KLi~VER, H., and BRUNSCHWIG, A. aqueous humor was not an isolated fluid but participated [Univ. of Chicago, Chicago, Ill.] THREE CARCINOMAS OF in general body reactions, and that its susceptibility to THE TONGUE IN TW0 MONKEYS. Cancer Research, 2: 704-709. 1942. tumor transfer was not determined by an antibody barrier. Three squamous cell carcinomas of the tongue occurred An interpretation of other reinoculation experiments simultaneously in two macaque monkeys (Macaca mulatta based on this conclusion suggested that the resistance- and Macaca irus) in a primate colony. One monkey died provoking powers of the tumors used were directly related of aspiration pneumonia with local tumor metastases, and to their growth rates and longevity. The ability of the the other died after operation, without metastases. At- various tumors to grow in partially resistant hosts ap- tempts at transmission were made but results remain peared, on the other hand, to be a function of their stromal negative after 3!/2 months. None of the commonly quoted requirements.--Author's abstract. etiological factors for cancer of the tongue in man were present except that both animals were elderly males. Both COMPARATIVE ONCOLOGY had experimental brain lesions of long standing. This is the first report of cancer of the tongue in subhuman BLOOM, F. [Flushing, N. Y.] SPONTANEOUS SOLITARY AND MULTIPLE MAST CELL TUMORS ("MASTOCYTOMA") primates, and also the first in nondomesticated animals. IN DOGS. Arch. Path., 33:661-676. 1942. An addendum refers to a case of carcinoma of the Neoplasms of the skin are very frequent in dogs, and in tongue in a horse (Henson, I. Am. Vet. M. A., 94: I24. a group of 49 primary cutaneous tumors the author has i939) , and to a third instance of carcinoma of thc tongue encountered 5 of which the histologic structure consisted in a macaque.--Authors' abstract.

t~TIOLOGY DONOVAN, M. S., and WARREN, S. [New England Dea- coness Hosp., Boston, Mass.] PERSISTENCE OF TUMOR CRAMER, W. [Barnard Free Skin and Cancer Hosp., St. AFTER PREOPERATIVE RADIUM TREATMENT FOR CAN- Louis, Mo.] THE ORIGIN OF CANCER IN MAN. J. A. M. A., CER OF THE CORPUS UTERI. Surg., Gynec. & 0bst., T4: 119:309-316. 1942. 1106-1111, 1842. An excellent lecture discussing the etiology of cancer A review of 46 proved cases of carcinoma of the uterine in the light of modern research. From a correlation of body, treated by uterine radon and complete hysterectomy the results obtained by the study of experimental car- at least 6 weeks after irradiation. In only 5 was the uterus, cinogenesis in animals, with clinical and pathological ob- when removed, found to be free from carcinoma. This servations, and with statistical investigations on cancer in investigation does not throw light on the question of the man, it has become evident that there is a multiplicity of value of radiation in preventing vaginal metastasis. In de- etiologic factors and that the etiology of cancer in man, ciding whether or not to use preoperative radiation, the as in animals, has to be considered a separate problem for relative advantages of possibly destroying the tumor or each organ. We are entitled now to consider the possi- decreasing its chances of implantation must be balanced bility of preventing several forms of cancer in man by against the delay and inconvenience to the patient.-- attacking the disease at its origin instead of remaining on H. G.W. the defensive until the disease has attacked man. This HOLMES, G. W. [Harvard Med. Sch., Boston, Mass.] article should be read by all interested in cancer from any THE PRESENT STATUS OF IRRADIATION TREATMENT standpoint.--H. G. W. IN NEOPLASTIC DISEASE. Texas State J. Med., 37:481- 486, 1941. A general review.--M. J. E. RADIATION--DIAGNOSIS AND THERAPY ~vVlGBY, P. E. [Houston, Tex.] INTRA-0RAL RADIA- CASE, J. T. [Northwestern Univ. Med. Sch., Chicago, Ill.] TION THERAPY. Texas State J. Meal., 3~':422-428. 1941. A CLINICAL APPROACH TO THE ROENTGEN DIAGNOSIS OF CARCINOMA OF THE COLON. Illinois M, J., 80:145-152. Of ~8 patients with tumors in the mouth, treated with 1941. roentgen radiation, 6 were symptom-free after I to 3 An extensive review of the clinical and roentgenographic years, and I2 died. Photographs illustrate the technic features of cancer of the colon is presented.--M. J. E. employed.--M. J. E.

SKIN AND SUBCUTANEOUS TISSUES associated with cerebral neoplasms, they are now known to be late effects of the disease, dependent upon an in- BROWN, J. B. and McDOWELL, F. [Washington Univ. Seh, of Med,, St. Louis, Mo.] "FIELD-FIRE" AND INVA- crease in intracranial pressure. The general nature of the SIVE BASAL CELL CARCINOMA--BASAL-SQUAMOUS initial symptom complex is subject to variation because of TYPE. Surg., Gynec. & 0bst,, 74 :112 B-1132. 1942. differences in the structure of the tumors or in their loca- The term "field-fire" is applied to basal cell carcinomas tion. Even when a growth does not produce a sudden which have pronounced superficial invasive properties, onset of alarming symptoms, eventually some steadily and often a center that appears free from involvement. increasing dysfunction of the nervous system will be in- Microscopically this tumor shows an advancing edge of duced. Abnormalities in the electroencephalographic rec- basal cell carcinoma, while in the center there is left ords may assist in the localization of approximately 5o% scarred derma and scar epithelium. Invasive basal cell of the tumors. The usual roentgen studies frequently carcinoma is a clinical type which once firmly established offer corroborative evidence, but it may be necessary to is practically incurable with the means now at our com- resort to encephalography or ventriculography, especially mand. It may recur years after operative removal. Basal in those patients without papilledema. Arteriographic in- cell carcinomas are definitely more dangerous than is vestigations are not as yet sufficiently standardized to per- generally thought and taught.--H. G. W. mit an estimate of their possible ultimate value.--M. J.E. W00LHANDLER, H. W., and BECKER, S, W. [Univ. of Chicago Sch, of Med,, Chicago, Ill,] ADENOMA OF SEBACEOUS GLANDS (ADENOMA SEBACEUM). WITH EYE CONSIDERATION OF KERATOTIC ADENOMA SEBACEUM AND TRUE ADENOMA OF SEBACEOUS GLANDS, Arch. AVERY, J. W,, and WARREN, ft. W. [Hollywood, Calif.] Dermat. & Syph,, 4.~:734-756. 1942, AN UNUSUAL CASE OF HODGKIN'S DISEASE, A PRE- LIMINARY REPORT, Arch, Ophth,, '-'~; :1019-1022. 1941, Analysis is made of 28 cases of various types of so called Involvement of the eye by Hodgkin's disease is unusual. adenomas of the sebaceous glands. Although a majority In the case recorded the patient had evidence of general- of the members of this group are not true adenomas, the ized lymphadenopathy. The diagnosis was made by designations are convenient in view of the uncertainty which exists concerning the use of the term "adenoma." biopsy. Bilateral masses in the outer aspects of the eye- balls were presumptively of the same nature. The general The disease may be divided into 7 groups: adenoma sebaceum (Balzer), adenoma sebaceum (Pringle), ac- and ocular lesions regressed following roentgen therapy, quired (senile) adenoma, keratotic adenoma sebaceum, and the patient appeared well 2 years later.--M. I.E. sebaceous gland adenoma, nevus sebaceus, and nevus pig- KLIEN, B. A, [Rush Med. Coll,, Univ. of Chicago, Chicago, mentosus et sebaceus.--H. G. W. Ill,] DETACHMENT OF THE PARS CILIARIS RETINAE. A CONTRIBUTION TO THE DIAGNOSIS OF MALIGNANT INTRAOCULAR TUMORS. Arch, 0phth,, :~{;:347-357. 1941. NERVOUS SYSTEM Detachment of the pars optica of the retina occurs in a HARTMAN, H., and HELFER, L. M, [San Antonio, Tex.] variety of conditions, but when combined with involve- METASTATIC TUMORS INVOLVING THE CENTRAL NER- ment of the pars ciliaris, the presumptive diagnosis oph- VOUS SYSTEM, Texas State J. Med,, 37:587-592. 1942. thalmoscopically is malignant intraocular tumor. These Eight cases of involvement of the brain or spinal cord findings, dependent upon an increase in subretinal pres- by metastases are recorded. Clinically the process did not sure, are, therefore, of singular value in the early diagno- differ from that associated with primary growths of the sis of tumors of the eye. Illustrations are included.-- nervous system. The presence, in 5 patients, of melanoma M. I.E. secondary to untreated or inadequately treated tumors of ROTTIN0, A,, and KELLY, A, S. [St, Vincent's Hosp,, New the skin, was ascertained by operation or necropsy. In i York, N. Y.] SPECIFIC NERVE SHEATH TUMOR OF ORBIT case, a metastatic hypernephroma in the brain was extir- (NEURILEMMOMA, NEURINOMA), REPORT OF A CASE pated under the assumption that it was the primary WITH REVIEW OF LITERATURE, Arch. Ophth,, 26:478-488. neoplasm since evidence of a new growth in the kidney 1941, was not present. One patient had a mediastinal neoplasm A neurinoma of characteristic morphology was success- extending into the dorsal vertebrae, and another, multiple fully excised from an eyeless orbit. The eye had been loci of invasion of the spine, skull, and cervical lymph removed 20 years previously because of the existence of nodes, by a Ewing's sarcoma.--M. J. E. a neoplasm, the nature of which cannot now be ascertained.--M. J. E. RITTER, S. A. [Misericordia Hosp,, New York, N, Y,] PRIMARY NEUROGENIC SARCOMA OF THE FORE&RM SAMUELS, B. [New York, N, Y.] TUMORS OF CONJUNC- FOLLOWING TRAUMA AT GOLF, CASE REPORT. Am. J, TIVA AND LIDS, A BRIEF REVIEW, Arch. 0phth., '-'6:789- Surg., 56:501-503. 1942, 796, 1941, The tumor arose at the site of a trauma received but The clinical aspects and the treatment of these neoplasms 5 weeks before. It was removed, and there has been no are reviewed.--M. J. E. recurrence in 2~/z years.--H. G. W. STOUGH, J. T. [Houston, Tex.] MEI",ANOSARCOMATA WALKER, A, E. [Univ. of Chicago, Chicago, Ill,] EARLY OF THE LID MARGIN AND CONJUNCTIVA: WITH CASE DIAGNOSIS OF BRAIN TUMORS, Illinois M, J., SO : 286-292. REPORTS, Texas State J. Med., 37:675-679. 1942, 1941. Tw,o cases of melanoma developing in pigmented zones While such classical manifestations as headache, vomit- present in the eye since birth are recorded. In the first, ing, and choked discs have always been considered to be melanoma of the ocular conjunctiva was treated success-

Downloaded from cancerres.aacrjournals.org on September 28, 2021. © 1942 American Association for Cancer Research. 804 Cancer Research fully by means of 2 extensive local resections and the PRIMARY UTERINE CARCINOMA COMPLICATING AN patient appeared cured after 5 years, while in the second, ADVANCED CASE OF MULTIPLE SCLEROSIS. Am..J. Clin. Path., 111:282-238. 1942. distant metastases from a growth on the lower lid de- Report of the condition described in the title in a 28 year veloped rapidly despite exenteration of the orbital tissues. old white woman.--H. G. W. --M. I.E. SERBIN, W. B. [Chicago, Ill.] CERVICAL POLYPS. BREAST Illinois M. J., 80:503~ 1941. While most cervical polyps are harmless, it is well to WAX, W. V. [Mere. Hosp. of Greene County, Catskill, N.Y.]. ULCERATING CANCER OF BREAST AS A PORTAL examine them for microscopic evidence of cancer. Thus, OF ENTRY FOR FATAL TETANUS. Am. J. Surg., 56:689- of 6 polyps removed by curettage, 2 contained areas of 683. 1942. malignant change. The insertion of radium is indicated Report of a unique case.--H. G.W. if malignancy has supervened.--M, l-E. YOUNG, T. O., and PARSON, E. I. [Duluth and Askov, SMITH, F. R. [Memorial Hosp., New York, N. Y.] THE Minn.] PATHOLOGICAL SIGNIFICANCE OF DISCHARGE EARLY DIAGNOSIS OF MALIGNANT TUMORS OF THE FROM THE NON-LACTATING BREAST. Journal-I, ancet, 61: FEMALE GENITAL TRACT. Illinois M. J., 80:218-222. 1941. 446-450. 1941. A general discussion is given.--M. J. E. Abnormal discharge from the breast, while almost VALH, W. I,. [Univ. of Michigan Med. Sch., Ann Arbor, always a sign of a lesion in the organ, is not necessarily Mich.] UROLOGICAL COMPLICATIONS OF CARCINOMA indicative of malignant tumor. Of 468 patients with mam- OF THE CERVIX. J. Urol., 47:686-688. 1942. mary disease, 40 (8.5%) had some form of discharge, Clinical discussion.--H. G. W. which usually was serosanguinous or frankly hemorrhagic. Nevertheless, the pathologic state in 13 patients was OVARY subsequently found to be a chronic cystic mastitis, in I2 BACH, A. C., and MONTGOMERY, M. M. [Cook County a papilloma, and in 15 a cancer. No relationship appeared Hosp., Chicago, Ill.] RUPTURE OF AN INFARCTED GRANU- to be discernible between the type of discharge and the LOSA CELL TUMOR OF THE OVARY WITH MASSIVE existing lesion.--M. J. E. HEMORRHAGE. J. Indiana M. A., 34:421-423. 1941. Clinically, the condition of a patient with shock and evidence of bleeding into the peritoneal cavity simulated FEMALE GENITAL TRACT ruptured ectopic gestation. Because of the severity of the COUlgSELLER, V. S. [Mayo Clinic, Rochester, Minn.] symptoms operation was not possible, and a postmortem CARCINOMA OF THE UTERUS. Surg. Clin. North Am., I!1: examination disclosed a twisted, ruptured granulosa cell 1189-1199, 1941. This review is concerned with the following aspects of tumor of the ovary.--M. I. E. carcinoma of the uterus: etiology, site, degree of malig- MARCHETTI, A. A. [Cornell Univ. Med. Coll., New York, nancy, extent of growth, symptoms, age distribution, diag- N.Y.] OVARIAN CANCER. CLINICOPATHOLOGIC EVALU- ATION. New York State J. Med., 41:2824-2831. 1941. nosis, and treatment.--]. L. M. Of the 60 malignant tumors in a series of I,I64 ovarian DEIBERT, A. V., and GREENBLATT, R. B. [U. S. Public masses examined, 44 were serous cystadenocarcinomas. Health Service Med. Center, Hot Springs, Ark., and Univ. of Radical extirpation supplemented by roentgen therapy was Georgia Sch. of Med., Augusta, Ga.] MALIGNANCY AND LYMPHOGRANULOMA VENEREUM. Am. J. Syph., Gonor. & possible in only 23 cases of the latter group. Eighteen Ven. Dis., 26 :830-335. 1942. patients died after an average duration of life of 16 months, A case is reported in which lymphogranuloma venereum while 4 still survived after periods averaging I i months, of the vulva in a 2 4 year old negress developed into a and I appeared cured 7 years after treatment. In the re- squamous cell carcinoma in the course of IO months. mainder in this group palliative measures consisting of --H. G.W. partial removal of the tumor, roentgen therapy, or para- KEI, S0, J. W. [Univ. of Oklahoma Sch. of Med., Oklahoma centesis were instituted. Only isolated examples of other City, 0kla.] CARCINOMA OF THE CERVIX. South. M. J., types of malignant neoplasms were observed, and the 3,~:590-593. 1942. results of therapy were equally discouraging. Of special Clinical considerations are discussed, with emphasis on interest was the cure by operation, generally followed by the use of radium and x-rays. The accomplishments of irradiation, of all 13 patients with histologically benign propaganda are pointed out: "A cancerphobia has never serous cystadenoma, but with such malignant clinical fea- metastasized and has never killed."--H. G. W. tures as papillary excresences on the external surface of McNAMARA, F. P. [Finley Hosp., Dubuque, Iowa] HOW the ovarian mass, rupture of the capsule, or implantations NOT TO TREAT CANCER OF THE UTERINE CERVIX. J. on the peritoneum.--M. 1. E. Iowa M. Soc., 31:484-436. 1941. The inadvisability .of treating unexplained uterine bleeding symptomatically is illustrated by a case report. ~V~ALE GENITAL TRACT The patient received hormones and small doses of radium, ADAMS, J. E. [Peter Bent Brigham Hosp., Boston, Mass.] while the cause of an eroded cervix was not investigated. A STUDY OF MALIGNANT TESTICULAR TUMORS IN- When a hysterectomy was performed at a later date, ex- CLUDING CASE REPORTS OF CHORIONEPITHELIOMA ACCOMPANIED BY HYPERTENSION AND TERATOMA tensive invasion of the uterine wall from a cancer of the TESTIS WITH SINGLE TRIDERMAI, METASTASES. J. cervix had already occurred.--M. I. E. Urol., 47:491-507. 1942. MITCHELL, N., and ANGRIST, A. [Queen's Gen. Hosp., A study of 21 malignant testicular tumors lends support Jamaica, N. Y.] MASSIVE METASTASIS TO BRAIN FROM to the theory that these tumors, including seminomas and

chorionepitheliomas, have a common origin in spermato- transurethral resection, io survived at least 3 years, 3 at genic cells. Such cells may be pluripotential and give least 5 years, and I appeared tumor-free after 7 years.~ rise to tridermal metastases, as in the case reported. M. J.E. Trophoblastic tissue may be present in teratoma testis THOMPSON, G. J., and EMMETT, ft. I,, [Mayo Clinic, more often than is commonly supposed, and this would Rochester, Minn,] CARCINOMA OF THE PROSTATE. Surg. account for the large amounts of gonadotrophic hormone Clin. North Am., 21:1181-1187. 1941. in the urine of patients with such tumors. The occurrence Malignant lesions of the prostate are discussed under of hypertension in association with the excretion of large the following headings: incidence, clinical diagnosis, me- amounts of gonadotrophic hormone in the urine is tastasis, conservative surgical treatment, and results of noted.~H. G. W. such treatment.--J. L. M. FRIEDMAN, H. H., and GRAYZEL, D, M, [Jewish I-Iosp., Brooklyn, N, Y.] MYOMATOUS TUMORS OF THE EPI- ORAL CAVITY AND UPPER RESPIRATORY TRACT DIDYMIS, J. Urol., 47:475-481. 1942. A case of myoma of the epididymis is reported, with PIGI, F. A. [mayo Clinic, Rochester, Minn.] CANCER OF THE PHARYNX AND LARYNX. Surg. Clin. North Am., a review of the other 12 cases in the literature.--H. G. W. 21:1027-1935. 1941. GRAVES, R. C., and LAWRENCE, K. B. [Pondville State This discussion includes the different diagnostic and Hosp., Walpole, Mass.] BILATERAL EMBRYONAL CARCI- therapeutic problems of tumors of the nasopharynx, tonsils NOMA OF THE TESTICLE WITH A NOTE ON THE TECH- NIQUE OP 0RCHIDECTOMY FOR MALIGNANT DISEASE, and oropharynx, base of the tongue and hypopharynx, and J. Urol,, 47:482-489. 1942, larynx.--J. L. M. Report of an instance of unusually large tumors, weigh- ins 800 and 9oo gin., removed by operation.--H. G. W. SALIVARY GLANDS McC00K, W. W. [Fort Brags, N. C.] LEIOMYOMA 0F DOCKERTY, m, B,, and MAYO, C. W. [Mayo Clinic, THE SPERMATIC CORD. CASE REPORT. Am. J. Surg., ~6:499-500, 1942. Rochester, Minn,] PRIMARY TUMORS OF THE SUB- mAXILLARY GLAND WITH SPECIAL REFERENCE TO Report of the fourth case, with three others found in MIXED TUMORS. Surg,, Gynec. & 0bst., ~r4:1033-1045. 1942. the litcraturc. The tumor occurred in a 66 year old negro.~ Of 81 cases, adenocarcinoma, mixed tumor type, was H. G. W. found in 51, cylindroma type in ~5, intermediate form in O'BRII~N, M. G. [Scranton, Pa.] PRIMARY SARCOMA 0F 7, and miscellaneous tumors in 8. There were more THE EPIDIDYMIS: CASE REPORT. J. Urol., 47:311-319. 1942. fcmalcs than males in this series. The youngest patient Only 9 ~ instances of this tumor are recorded. This was T2 years old. True mixed tmnors are of epithelial number includes the author's case, in which trauma origin, are inherently malignant, and should be removed seemcd to be the etiological factor since the tumor fol- with the salivary gland and regional lymph nodes. A lowed 6 months after a violent blow to the scrotal special tendency to invade perineural lymphatic structures, region.~H. G. W. analogous to that occurring with prostatic cancers, is seen here especially with the cylindrolna type.--H. G.W. TWINEM, 1% B. [New York, N. g.] BENIGN TERATOMA OF THE TESTICLE IN A THREE YEAR OLD BOY: A Mcl~ARLAND, ft. [Univ. of Pennsylvania Sch. of Med., CASE REPORT. J. Urol., 47:577-579. 1942, Philadelphia, Pa.] THE HISTOPATHOLOGIC PROGNOSIS A case is reported.--H. G. W. OF SALIVARY GLAND MIXED TUMORS. Am. J. M, Sc., "203:502-519. 1942. A long-time study of about 400 mixed tumors of the PROSTATE salivary glands leads to the conclusion that something BALCtI, J. 1% [Indianapolis, Ind.] CARCINOMA OP THE more than a simple microscopic examination of a section PROSTATE~NEW METHODS 0P MANAGEMENT AND of tissue will be required before an accurate prognosis TREATMENT. ft. Indiana m, A,, 34:672-674, 1941. of a mixed tumor of the salivary glands becomes pos- Two examples are recorded of the astonishing clinical sible. "At present our methods are no more accurate or and objective improvement which occurs after bilateral scientific than the flipping of a coin." Although the av- orchidectomy in patients with inoperable cancer of the erage period between operation and recurrence is 7 years, prostate with or without skeletal metastases.~M. J. E. the fact that it may be much longer, even as long as 45 BUMPUS, tI. C., Jr. [Coll. of Med. Evangelists, Los years, raises the question whether any patient is ever out Angeles, Calif.] CANCER 0F THE PROSTATE. California & of danger. The distribution of the mixed tumors in this West, Med., 5.~:239-241. 1941, series, according to origin, was :z sublingual, I). submaxil- 'Prostatic cancers frequently proliferate slowly and not law, and 380 parotid. There were i84 in males and 2~2 rarely untreated individuals or those who have received in females, distributed about equally to the right and left only palliative therapy survive many years in acceptable sides. The frequency of recurrence of the interstitial health. These circumstances make difficult an evalua- tumors was 38% and of the parenchymatous or epithelial tion of therapeutic measures. Tumors are rarely encoun- tumors 6o%, while the highest percentage of recurrence, tered in an early stage, and when sufficiently large to be 81.8, was in the papillary canalicular group. About 5o palpable are generally inoperable, as local extension in microscopic slides were submitted to 25 competent mi- the perineurat lymphatics about the organ occurs readily. croscopists who gave their opinions as to the probability In such cases, however, palliation is indicated, and may of the recurrence of each type of tumor; 52~ of the prove encouragingly successful. Of 34 patients treated by opinions were correct and 48% were wrong.--H. G. W.

W00DSON, B. [Temple, Tex.] BENIGN MIXED TUMOR ing growth. The incidence in the two sexes is nearly OF THE PHARYNGOMAXILLARY SPACE AND RELATED AREA: REPORT OF A CASE. Texas State J. Med., 37: identical, in contrast to the overwhelming predominance 785-788. 1942. of bronchiogenic carcinoma in the male. No metastases A mixed tumor, possessing the characteristic morphology were found in approximately half the cases. There are of the type encountered more commonly in the salivary tabulated 25 cases of what seem to be, undoubtedly, glands, was extirpated from the pharyngomaxillary space, alveolar cell tumors, 15 cases that are controversial, and an area situated internal to the ramus of the mandible 4 cases of lung tumors with some characteristics of the and bounded by the deep muscles and fascia of the neck.-- alveolar cell tumor.--H. G. W. M. I.E. NEUHOF, H., RABIN, C. B., and SAROT, I. A. [Mt. Sinai Hosp., New York, N. Y.] A TOPOGRAPHIC CLASSIFICA- TION OF CANCER OF THE LUNG, ~rITH SPECIAL REFER- INTRATHORAClC TUMORS--LUNGS--PLEURA ENCE TO THE SURGICAL IMPLICATIONS OF THE CIRCUM- SCRIBED VARIETY. J. Thoracic Surg., 11:388-~95. 1942. ALEXANDER, J. [Univ. of Michigan Med. Sch., Ann Arbor, Mich.] CIRCUMSCRIBED INTRATHORACIC NEOPLASMS. Gross topographic features were studied with special J, A. M. A., 119 :395-397. 1942. reference to operability in 28r cases of primary cancer of Contrary to the prevailing impression, the majority of the lung. Origin from a branch bronchus could be seen circumscribed intrathoracic neoplasms are intrapulmonary in most of the circumscribed tumors which constituted and malignant. Many circumscribed extrapulmonary neo- 29% of the series. A bronchial origin could be seen in all plasms are malignant, and those that are benign n-my cases of noncircumscribed tumors, five-sixths of which orig- undergo malignant degeneration or cause disability or inated in large bronchi. Distinctive roentgenologic fea- serious complications as a result of increase in size. Ex- tures existed in the majority of tile circumscribed tumors, cept for those bronchogenic and esophageal carcinomas of which 57% were clinically operable. Twenty-nine of that yield endoscopic biopsy material and those neoplasms these patients were operated upon: ~6 were found free that have metastasized, a preoperative determination of from regional lymph node involvement, while 6 had mini- malignancy or benignancy cannot be made with reason- real lymph node involvement. Of the noncircumscribed able accuracy. Virtually all presumably removable neo- tumors but 39% were clinically operable; and of 3~ pa- plasms should be operated on promptly. The only proper tients in this group operated upon, only 9 were free from use of high voltage roentgen therapy is as a therapeutic test regional lymph node involvement.--H. G. W. for lymphoblastoma or for palliation in inoperable malig- 0CHSNER, A., and DeBAKEY, M. [Sch. of Med., Tulane nant neoplasms.--H. G. W. Univ., New Orleans, La.] SIGNIFICANCE OF METASTASES IN PRIMARY CARCINOMA OF THE LUNGS. J. Thoracic HAI~RINGTON, S. W. [Mayo Clinic, Rochester, Minn.] Surg., 11:357-387. 1942. PNEUMONECTOMY FOR CARCINOMA OF THE LUNG. J. Thoracic Surg., 11: 396-464. 1942. The widespread dissemination of metastases in carcinoma A discussion of surgical technic based on 3 ~ cases.~ of the lung is indicated by the following percentage fig- H. G.W. ures from 3,o47 necropsies: to the regional lymph nodes, 72.2; liver, 33.3; pleura, 29.8; lungs, 23.3; bone, 21.:3; ad- HARRINGTON, S. W., and MOERSCH, H. J. [Mayo Clinic, Rochester, Minn.] PRIMARY CARCINOMA OF THE LUNG. renals, 2o.3; kidneys, 17.5; brain, 16.5; heart and peri- Surg. Clin. North Am., 21:1083-1098. 1941. cardium, 12.7; pancreas, 7.3; peritoneum, 4.8; gastroin- Because of the relatively short period of time that car- testinal tract, 4.3; skin, 3.6; spleen, 3.5; thyroid, 2.3; cinoma of the lung has been treated surgically, it is im- tonsil, 1.8; tongue, 1.6. Undoubtedly these figures would possible to predict the ultimate place surgery will have be raised by more thorough examinations, especially in re- in the treatment of this disease. The technical surgical gard to the metastases in the brain and bones. Two cases problems at the present time have been solved to a point are reported in which pneumonectomy was followed by which makes the operative mortality relatively small. metastases in the axillary nodes, presumably via adhesions With the improvement in the operative procedures which from the lungs. The lymphatic drainage of the lungs is is constantly taking place, as well as improvement in early briefly described and the various possibilities of metastatic diagnosis, it would appear that surgical treatment is the extension by this route are indicated.--H. G. W. treatment of choice.--J. L. M. SANDERSON, R. B. [South Bend, Ind.] CANCER OF THE LUNG. J. Indiana M. A., 34:463-466. 1941. NEUBUERGER, K. T., and GEEVER, E. F. [Univ. of Colorado Sch. of Med., Denver, Col.] ALVEOLAR CELL A description of 2 cases illustrates the confusing, non- TUMOR OF THE HUMAN LUNG. Arch. Path., 33:551-569. specific nature of the symptomatology associated with 1942. cancer of the lung, and the difficulty of establishing a cor- A survey of the literature convinces the authors that rect early diagnosis even in those fortunate instances occasional lung tumors in man, similar to the common when the patient does not delay in seeking the advice of lung tumors of mice, arise from the lining cells of the the physician.--M. I. E. alveolar walls, though they are certainly not more than 5% of all lung tumors. Although the growth is generally HEART called carcinoma, the term "alveolar cell tumor" is to be DOANE, J. C,, and PRESSMAN, R. [Jewish Hosp., Phila- preferred because of the uncertainty of the histogenesis delphia, Pa.] ANTEMORTEM DIAGNOSIS OF TUMORS OF and the prevalence of the idea that the alveolar lining THE HEART. Am. J. M. Sc., ~O3:520-524. 1942. is not epithelium. This tumor arises as a multiple nodular A case of metastatic carcinoma of the heart secondary neoplasm or, less commonly, as a diffuse or lobar infiltrat- to a growth in the uterus, diagnosed clinically, is added to

Downloaded from cancerres.aacrjournals.org on September 28, 2021. © 1942 American Association for Cancer Research. Abstracts 807 the 2o recorded in the literature. Of these 20 instances, KISTLER, G. H. [Chattanooga, Tenn,] CARCINOMA OF THE RECTUM. J. Tennessee M. A., 34:390-395. 1941. 13 were sarcomas and 7 carcinomas. In 5 the primary tu- The needs and indications for prompt surgical interven- mor involved the lung. In 9 of the 2o cases, the right tion are stressed.--M. J. E. auricle alone was involved.--H. G. W. MANHEIM, S., and PESKIN, H. [Mt. Sinai Hosp., New York, N. Y.] SPONTANEOUS ELIMINATION OF A LIPOMA GASTROINTESTINAL TRACT FROM THE SIGMOID FLEXURE. J. A. M. A., 11S:1214-1215. 1942. COSTEN, J. B., and BRYAN, W. T. K. [Washington Univ. A x9th case is added to the literature. The tumor in Sch. of Med., St. Louis, Mo.] THE DIAGNOSIS OF CAR- CINOMA OF THE ESOPHAGUS. Illinois M. J., 80 :274-280. this instance measured 6 x 4 x 4 cm. and recovery was 1941. uneventful.--H. G. W. The symptoms in patients with esophageal cancer are MARKOWITZ, B. [Bloomington, Ill.] BONE CARCINOMA- generally clearly indicative of the lesion, and the clinical T0SIS SIMULATING PERNICIOUS ANEMIA (A CASE RE- diagnosis may be confirmed readily by roentgenographic PORT). Illinois M. J'., 80:296-298. 1941. and esophagoscopic examination. Unfortunately the pa- Necropsy disclosed a cancer of the stomach with diffuse tients are rarely seen before the growth has extended skeletal metastases in a patient who had been considered widely. In some instances, however, patients with the to have pernicious anemia. Liver therapy had proved symptoms of the condition nmy have secondary involve- valueless.--M. J. E. ment of the organ, or a nonneoplastic disorder. Thus MAYO, C. W. [Mayo Clinic, Rochester, Minn.] MALIG- the authors note examples of cancer of the cardia, larynx, NANT LESIONS OF THE LOWER PORTION OF THE SIG- MOID, RECTOSIGMOID, RECTUM AND ANUS, WITH or trachea extending into tire esophagus; metastases of SPECIAL REFERENCE TO ONE-STAGE COMBINED more distant tumors situated in the breast or stomach; ABDOMINOPERINEAL RESECTION. Surg. Clin. North Am., tuberculosis of the larynx inw31ving the esophagus; and 21:1129-1141. 1941. a stricture secondary to adhesions about the organ as a This article is concerned with the present status of the result of an earlier fracture of a lower dorsal vertebra. one-stage combined abdominoperineal resection in cases --M. I.E. of malignant lesions of the lower part of the sigmoid, GILCHRIST, R, X, [Chicago, Ill.] SURGERY OF CAR- rectosigmoid, rectum, and anus. The author's discussion CINOMA OF THE COLON AND RECTUM. Illinois M. J., SO: is based on a review of I79 consecutive cases in which 249-252. 1941. operation was performed. There were '5 deaths in this The importance of performing as extensive a resection series. The latter figure includes deaths from all causes, as possible in patients with operable cancers of the large regardless of the time the patients remained in the hos- bowel is demonstrated by the incidence of metastatic loci pital. In the last i44 cases, the mortality rate was 5.5% in 65% of the resected lymph nodes draining the tumor and in the last 74 cases there were no deaths.--J. L. M. area.--M. J. E. MORRISON, W. A., and DONATH, D. [Los Angeles, Calif.] GOLOB, M., IPOLITT0, T., and NUSSBAUM, C. [Metro- TUMORS OF THE SMALL INTESTINE. California & West. politan Hosp., New York, N. Y.] CANCER OF THE STOM- Med., 55:235-237. 1941. ACH. Rev. Gastroenterol., 9:120-132. 1942. Of 45 examples of tumor of the small intestine observed An analytic survey of Jo 4 cases, which emphasizes the at operation or autopsy, 26 were malignant and ~9 benign. lack of pathognomic signs and symptoms in early car- The most comtnon type of the former group was adeno- cinoma of the stomach.--H. G. W. carcinoma or fibrosarcoma; of the latter, fibromyoma, adenoma, or carcinoid. Malignant neoplasms generally pro- GREGG, R. 0., and DIXON, C. g. [Mayo Clinic, Rochester, Minn.] OPERABLE MALIGNANT LESIONS OF THE COLON duced clinical evidence late in their course, and the pa- PRODUCING OBSTRUCTION. Surg. Clin. North Am., 21:1143- tients died of metastases or perforation. Benign tumors 1152. 1941. were either incidental findings or produced intestinal ob- This paper is based on a review of the records of all struction of gradually increasing severity. The latter could patients examined at the Mayo Clinic from I9o 7 to x938 be ameliorated by resection of the lnass.--M. J. E. who had resectable malignant lesions of the colon, exclu- RANKIN, F. W. [Lexington, Ky.] MODERN MANAGE- sive of the rectum. Of the 2,73o patients examined, i2i MENT OF CANCER OF THE LOWER GASTROINTESTINAL had acute obstruction of the colon. Of 76 patients hav- TRACT. Surg., Gynec, & 0bst., T4:905-913. 1942. ing acute obstruction who survived operation, 75 were A clinical report based on 258 cases with surgical traced for a period of at least 5 years. Twenty-six of the intervention.--H. G. W. 75 patients, or 34-7%, survived longer than this period; WALTERS, W., GRAY, H. K., and PRIESTLEY, J. T, only 22.4% of the original II6 who had an operation and [Mayo Clinic, Rochester, Minn,] MALIGNANT LESIONS OF THE STOMACH: RESULTS OF TREATMENT IN THE could be traced, survived 5 years. This is about 6o% of YEARS 1907 TO 1938 INCLUSIVE. Surg. Clin. North Am, the average survival for all patients examined at the Clinic ~1:1099-1115. 1941. with lesions in these segments of the bowel, and only about In the years ~9o7 to ~938, a diagnosis of malignant 7o% of the average survival rate for those patients lesion of the stornach was made in iI,ooo cases observed recovering from surgical intervention. at the Mayo Clinic, and operation was performed in The authors believe that obstruction of the colon is 6,352 . These surgical cases are reviewed as to type of associated in some manner with the poor prognosis for lesion, distribution by age and sex, sympton-mtologic patients having malignant lesions of the colon.--J. L. M. aspects, value of response to treatment as a guide to

Downloaded from cancerres.aacrjournals.org on September 28, 2021. © 1942 American Association for Cancer Research. 808 Cancer Research malignancy, relationship of physical observations to rate THOMAS, A. [Denver, Colo.] VASCULAR TUMORS OF BONE. Surg., Gynec. & Obst., 74 : 777-795. 1942. of removability, roentgenologic diagnosis, grade of ma- An analysis of the 27 cases in the Bone Sarcoma Regis- lignancy and removability of the lesion, treatment and try of the American College of Surgeons. There are 1:,- results, mortality and survival rates, and grade of malig- cases of benign angiomas and I5 of malignant angiomas, nancy and prognosis.--J. L. M. considered to be true endotheliomas. The Ewing tumors SCHINDLER, R. [Univ. of Chicago, Chicago, Ill.] THE are not included. The benign forms possess certain roent- GASTRIC MUCOSA IN BENIGN ADENOMAS. Am. J. Digest. Dis., 9:149-150. 1942. genographic and pathologic features that are practically Gastroscopic observations of 36 cases of benign gastric diagnostic. It is suggested that the malignant angiomas of adenomatous polyps lead to the conclusion that atrophic bone can be divided into angioendotheliomas, which have gastritis has a 7 times greater predisposition to the forma- an epithelium-like structure difficult to distinguish from tion of such tumors than has the normal gastric mucosa. metastatic carcinoma, and angiosarcomas, which have a However, 15 of 36 patients with adenomatous gastric greater vasoformative tendency. The malignant angiomas polyps did not have an atrophic gastritis, as seen gas- possess few roentgenographic or clinical features distin- troscopically.~H. G. W. guishing them from other malignant tumors of bone. They are only moderately radiosensitive, and early diagnosis and radical surgical treatment are essential for cure. LIVER ~H. G.W. GRAY, H. K., and SHARPE, W. S. [Mayo Clinic, Rochester, Minn.] CARCINOMA OF THE GALLBLADDER, EXTRA- MUSCLE AND TENDON HEPATIC BILE DUCTS AND THE MAJOR DUODENAL PAPILLA. Surg. Clin. North Am., ~-1:1117-1127. 1941. FULTON, M. N,, and SOSMAN, M. C. [Harvard Med. Sch., This review is based on a study of 464 cases in which Boston, Mass.] VENOUS ANGIOMAS OF SKELETAL MUSCLE. operation was performed for carcinoma of the gall bladder J. A, M. A., 119:319-324. 1942. and extrahepatic bile ducts at the Mayo Clinic in the In 4 cases of venous angioma of skeletal muscle, diagno- years ~9o7 to ~94o.--J. L.M. sis was made by x-ray determination of phleboliths, which are practically pathognomonic of this tumor when occurring in areas where normally no plexus of veins exists. BONE AND BONe MARROW Injection of radiopaque material is of value in outlining the 9BEIZER, L. H., HALL, B. E., and GIFFIN, H. Z. [Mayo extent of the tumor. Surgical excision is the treatment of Clinic, Rochester, Minn.] THE DIAGNOSIS OF MULTIPLE choice but roentgen therapy may be used when extirpation MYELOMA BY STERNAL ASPIRATION. Am. J. M. Sc., ~O8:829-836. 1942, is impossible.--H. G. W. The presence of myeloma cells in bone marrow obtained GROSS, P., and CAMERON, D. W, [Western Pennsylvania by sternal aspiration is pathognomonic of multiple mye- Hosp., Pittsburgh, Pa.] SYNOVIALOMA. Arch. Path., 33: 687-690. 1942. loma. An increase in the proportion of typical and atypical About 4 8 tumors derived from synovia have been re- plasma cells is suggestive, but the absence of abnormal ported, to which is added one arising in a suprapatellar findings does not rule out the possibility of multiple bursa. This tumor had been growing for more than 3 ~ myeloma. Of Io cases, sternal aspirations confirmed the years and showed no evidence of recurrence 5 years after diagnosis in 8, and in the 9th an increased proportion of surgical removal.--H. G. W. the cells were plasma cells.--H. G. W. HAGGART, G. E, [Lahey Clinic, Boston, Mass.] SYNO- HARPER, F. R. [Denver, Colo.] HUGE CHONDR0- VIOMA OF THE KNEE JOINT. J. Bone & Joint Surg., "-'4: SARCOMA ARISING FROM THE CHEST WALL AND EX- 438-442. 1942. TENDING INTO THE THORAX AND ABDOMEN. J. Thoracic Report of a case without recurrence 8 years after re- Surg., 11:446-450. 1942. moval.--H. G. W. A tumor 3 ~ cm. in diameter arose at the site of a trauma.--H. G. W. LEUKEMIA~ LYMPHOSARCOMA~ HODGKIN'S DISEASE MEYERDING, H. W. [Mayo Clinic, Rochester, Minn.] SOME COMMENTS ON MALIGNANT TUMORS OF BONE. CARY, W. [Finley Hosp., Dubuque, Iowa] SUBLEUKEMIC Surg. Clin. North Am., '21:1153-1162. 1941. LYMPHATIC LEUKEMIA WITH SECONDARY ANEMIA. This review discusses types of malignant tumors of J. Iowa M. Soc., 31:284-285. 1941. bone, their diagnosis, and an evaluation of methods of A diagnosis of lymphatic leukemia was established by treatment. At the present time, surgery is unquestionably examination of the sternal marrow in a patient with the most efficient method of treatment in cases of malig- severe anemia and only suggestive signs of leukemia in nant tumor of bone. In order to obtain the best results the peripheral blood. The almost complete limitation of from such surgical procedures, it is necessary that the the disease to the bone marrow was corroborated by patient be seen by a surgeon during the early stage of necropsy.--M. J. E. the disease, that immediate recognition of the type and HAINES, D. J. [Des Moines, Iowa] ACUTE LEUKEMIA. grade of malignancy be determined by microscopic ex- CASE REPORT. J. Iowa M. Soc., 31:430-432. 1941. amination of tissue, and that prompt treatment then be Fatal myeloid leukemia followed extraction of a tooth. Carried out.--J. L. M. --M. J.E.

Cancer Res 1942;2:802-808.

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