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Second in childhood/adolescence age. Experience in Institution. Hospital de Niños R. Gutierrez. Authors: M. Paula Robledo , Mariana Nana, Mercedes García Lombardi.

Unidad de Oncología. Hospital de Niños R. Gutiérrez. Gallo 1330. CP 1425. Buenos Aires, Argentina. E-mail: [email protected] Results Introduction First Tumor: Features: Second . Features: Second neoplasms (SN) are rare in children cancer survivors. Studies estimate that the cumulative probability of developing a SN to 25 years of initial diagnosis ranges from 3.3 to 5% Patients 22 Mean time to SN diagnosis 10.2 años (0.4-24.5). .The patient groups treated with specific chemotherapeutic agents (such as alkylating agents or Median age at diagnosis 4.4 years (0.3-14) Diagnostics: epipodophyllotoxins), those treated with radiation therapy and those who have a genetic Chemotherapy 21 p Leukemias/Lymphomas 7p (31,8%) predisposition to developing tumors have a higher risk to present a SN. Chemotherapy + 14 p 6p (27,2%) The aim of this study are: Radiotherapy 22 p CNS Tumors 4p (18,2%) - Report the second most common cancers in this age group. Complete Remission Extra-abdominal 2p - Describe factors associated with the development of SN: predisposing genetic factors and Genetic predisposition: 2 p Uterin fibroid 1p factors associated with treatment. (Chemotherapy and radiotherapy). Neurofibromatosis type 1 1 p Cystadenoma 1p - Compare results with literature. Hereditary Retinoblastoma. Wilms Tumor 1p Median age at diagnosis 15,5 años (r 3,7-27,5) Treatment with alkylating agents 17 p Materials and methods 2nd neoplasms Treatment with Etoposide 5 p Descriptive, retrospective study of patients treated in Oncology Unit of Hospital de Niños Ricardo Leukemias/L Radiation-induced Tumor 7p (de 14 que realizaron RT) ymphomas Gutierrez, between January 1986 and February 2016, which developed SN in Complete Remission 15 p (59%) Sarcomas pediatric/adolescence age. Deaths 8 p (36,4%) 23% 32% Third Tumor 1 p CNS Tumors Results 18% Overall Survival 63,6% 27% First solid Second neoplasm Others Follow up 75 meses (1,9-322,8) malignant tumor N ALL/AML NHL HL Sarcomas OS CNST Fibromatosis WT Cystadenoma ovarian Uterin

RMS 5 1 1 1 1 1 HL 4 1 1 1 1 Conclusions MB 3 1 1 1 -The most frequent diagnoses of SN (leukemias, lymphomas, sarcomas and CNS tumors) coincide with the RB 3 1 2 literature, as well as the association with alkylating agents and Etoposide. EwS 2 1 1 WT 1 1 - Half of patients who received RT and developed a second tumor , did in irradiated site. ChG 1 1 - Percentage of patients with SN in our study was 0.72%, which is lower than reported. This could be due to PPB 1 1 loss to follow up or because some patients continue their monitoring in adults center. HB 1 1 MPNST 1 1 References 1- Meadows, A. Friedman, D. Neglia, J. Second Neoplasms in Survivors of Childhood Cancer: Findings From the Childhood Cancer Survivor. Study Cohort. RMS: / HL:Hodgkin Lynphoma/ MB: Medulloblastoma / RB: Retinoblastoma / EwS: Ewing / TW: Wilms Tumor / ChG: Chiasmatic Glioma / Journal of Clinical Oncology. Vol 27. Num 14. Mayo 2009. PPB: /HB: / MPNST: Malignant Perifheral Nerve Sheath Tumor. OS: Osteosarcoma/ CNST: Central Nervous System Tumor. 2- Meadows, A. D´Angio, G. Miké V. Patterns of second malignant neoplasms in children. Cáncer 40:1903-1911,1977. 3- Jazbec, J. Ecimovic, P. Jereb, B. Second Neoplasms After Treatment of Childhood Cancer in Slovenia. Pediatr. Blood Cancer 2004;42:574-581. 4- Neglia, J. Friedman, D. Yutaka, Y. Second Malignant Neoplasms in Five-Year Survivors of Childhood Cancer: Childhood Cancer Survivor Study. Journal of the National Cancer Institute, Vol. 93, No. 8, April 18, 2001.