N3sim: Simulation Framework for Diffusion-Based Molecular
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Diamondoid Mechanosynthesis Prepared for the International Technology Roadmap for Productive Nanosystems
IMM White Paper Scanning Probe Diamondoid Mechanosynthesis Prepared for the International Technology Roadmap for Productive Nanosystems 1 August 2007 D.R. Forrest, R. A. Freitas, N. Jacobstein One proposed pathway to atomically precise manufacturing is scanning probe diamondoid mechanosynthesis (DMS): employing scanning probe technology for positional control in combination with novel reactive tips to fabricate atomically-precise diamondoid components under positional control. This pathway has its roots in the 1986 book Engines of Creation, in which the manufacture of diamondoid parts was proposed as a long-term objective by Drexler [1], and in the 1989 demonstration by Donald Eigler at IBM that individual atoms could be manipulated by a scanning tunelling microscope [2]. The proposed DMS-based pathway would skip the intermediate enabling technologies proposed by Drexler [1a, 1b, 1c] (these begin with polymeric structures and solution-phase synthesis) and would instead move toward advanced DMS in a more direct way. Although DMS has not yet been realized experimentally, there is a strong base of experimental results and theory that indicate it can be achieved in the near term. • Scanning probe positional assembly with single atoms has been successfully demonstrated in by different research groups for Fe and CO on Ag, Si on Si, and H on Si and CNHCH3. • Theoretical treatments of tip reactions show that carbon dimers1 can be transferred to diamond surfaces with high fidelity. • A study on tip design showed that many variations on a design turn out to be suitable for accurate carbon dimer placement. Therefore, efforts can be focused on the variations of tooltips of many kinds that are easier to synthesize. -
Survey on Terahertz Nanocommunication and Networking
1 Survey on Terahertz Nanocommunication and Networking: A Top-Down Perspective Filip Lemic∗, Sergi Abadaly, Wouter Tavernierz, Pieter Stroobantz, Didier Collez, Eduard Alarcon´ y, Johann Marquez-Barja∗, Jeroen Famaey∗ ∗Internet Technology and Data Science Lab (IDLab), Universiteit Antwerpen - imec, Belgium yNaNoNetworking Center in Catalunya (N3Cat), Universitat Politecnica` de Catalunya, Spain zInternet Technology and Data Science Lab (IDLab), Ghent University - imec, Belgium Email: fi[email protected] Abstract—Recent developments in nanotechnology herald Communication and coordination among the nanodevices, nanometer-sized devices expected to bring light to a number of as well as between them and the macro-scale world, will groundbreaking applications. Communication with and among be required to achieve the full promise of such applications. nanodevices will be needed for unlocking the full potential of such applications. As the traditional communication approaches Thus, several alternative nanocommunication paradigms have cannot be directly applied in nanocommunication, several alter- emerged in the recent years, the most promising ones being native paradigms have emerged. Among them, electromagnetic electromagnetic, acoustic, mechanical, and molecular commu- nanocommunication in the terahertz (THz) frequency band is nication [2]. particularly promising, mainly due to the breakthrough of novel In molecular nanocommunication, a transmitting device materials such as graphene. For this reason, numerous research efforts are nowadays targeting THz band nanocommunication releases molecules into a propagation medium, with the and consequently nanonetworking. As it is expected that these molecules being used as the information carriers [3]. Acoustic trends will continue in the future, we see it beneficial to nanocommunication utilizes pressure variations in the (fluid summarize the current status in these research domains. -
Nanomedicine and Medical Nanorobotics - Robert A
BIOTECHNOLOGY– Vol .XII – Nanomedicine and Medical nanorobotics - Robert A. Freitas Jr. NANOMEDICINE AND MEDICAL NANOROBOTICS Robert A. Freitas Jr. Institute for Molecular Manufacturing, Palo Alto, California, USA Keywords: Assembly, Nanomaterials, Nanomedicine, Nanorobot, Nanorobotics, Nanotechnology Contents 1. Nanotechnology and Nanomedicine 2. Medical Nanomaterials and Nanodevices 2.1. Nanopores 2.2. Artificial Binding Sites and Molecular Imprinting 2.3. Quantum Dots and Nanocrystals 2.4. Fullerenes and Nanotubes 2.5. Nanoshells and Magnetic Nanoprobes 2.6. Targeted Nanoparticles and Smart Drugs 2.7. Dendrimers and Dendrimer-Based Devices 2.8. Radio-Controlled Biomolecules 3. Microscale Biological Robots 4. Medical Nanorobotics 4.1. Early Thinking in Medical Nanorobotics 4.2. Nanorobot Parts and Components 4.3. Self-Assembly and Directed Parts Assembly 4.4. Positional Assembly and Molecular Manufacturing 4.5. Medical Nanorobot Designs and Scaling Studies Acknowledgments Bibliography Biographical Sketch Summary Nanomedicine is the process of diagnosing, treating, and preventing disease and traumatic injury, of relieving pain, and of preserving and improving human health, using molecular tools and molecular knowledge of the human body. UNESCO – EOLSS In the relatively near term, nanomedicine can address many important medical problems by using nanoscale-structured materials and simple nanodevices that can be manufactured SAMPLEtoday, including the interaction CHAPTERS of nanostructured materials with biological systems. In the mid-term, biotechnology will make possible even more remarkable advances in molecular medicine and biobotics, including microbiological biorobots or engineered organisms. In the longer term, perhaps 10-20 years from today, the earliest molecular machine systems and nanorobots may join the medical armamentarium, finally giving physicians the most potent tools imaginable to conquer human disease, ill-health, and aging. -
Mechanosynthesis of Amides in the Total Absence of Organic Solvent from Reaction to Product Recovery
Mechanosynthesis of amides in the total absence of organic solvent from reaction to product recovery Thomas-Xavier Metro, Julien Bonnamour, Thomas Reidon, Jordi Sarpoulet, Jean Martinez, Frédéric Lamaty To cite this version: Thomas-Xavier Metro, Julien Bonnamour, Thomas Reidon, Jordi Sarpoulet, Jean Martinez, et al.. Mechanosynthesis of amides in the total absence of organic solvent from reaction to product re- covery. Chemical Communications, Royal Society of Chemistry, 2012, 48 (96), pp.11781-11783. 10.1039/c2cc36352f. hal-00784652 HAL Id: hal-00784652 https://hal.archives-ouvertes.fr/hal-00784652 Submitted on 12 Feb 2021 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. ChemComm Dynamic Article Links Cite this: Chem. Commun., 2012, 48, 11781–11783 www.rsc.org/chemcomm COMMUNICATION Mechanosynthesis of amides in the total absence of organic solvent from reaction to product recoverywz Thomas-Xavier Me´tro,* Julien Bonnamour, Thomas Reidon, Jordi Sarpoulet, Jean Martinez and Fre´de´ric Lamaty* Received 31st August 2012, Accepted 8th October 2012 DOI: 10.1039/c2cc36352f The synthesis of various amides has been realised avoiding the use added-value molecules production. Pursuing our interest in of any organic solvent from activation of carboxylic acids with CDI the development of solvent-free amide bond formation,6 we to isolation of the amides. -
Toward a Wired Ad Hoc Nanonetwork
Toward a Wired Ad Hoc Nanonetwork Oussama Abderrahmane Dambri and Soumaya Cherkaoui INTERLAB, Engineering Faculty, Universite´ de Sherbrooke, Canada Email: fabderrahmane.oussama.dambri, [email protected] Abstract—Nanomachines promise to enable new medical appli- safety to use terahertz frequencies inside the human body for cations, including drug delivery and real time chemical reactions’ medical applications is another problem of electromagnetic detection inside the human body. Such complex tasks need coop- communication at nanoscale, which needs further research. eration between nanomachines using a communication network. Wireless Ad hoc networks, using molecular or electromagnetic- Molecular communication is a bioinspired paradigm that uses based communication have been proposed in the literature to cre- molecules as information carriers instead of electromagnetic ate flexible nanonetworks between nanomachines. In this paper, waves. Molecular communication is used by nature and can we propose a Wired Ad hoc NanoNETwork (WANNET) model be leveraged safely inside the human body. In [4], the authors design using actin-based nano-communication. In the proposed proposed a mobile ad hoc nanonetwork with collision-based model, actin filaments self-assembly and disassembly is used to create flexible nanowires between nanomachines, and electrons molecular communication. This Mobile Ad hoc Molecular are used as carriers of information. We give a general overview of NETwork (MAMNET) employs infectious disease spreading the application layer, Medium Access Control (MAC) layer and a principles using the electrochemical collision between mobile physical layer of the model. We also detail the analytical model nanomachines to transfer information. Another MAMNET of the physical layer using actin nanowire equivalent circuits, system is proposed in [5], by using Forster¨ Resonance Energy and we present an estimation of the circuit component’s values. -
Scanning Tunneling Microscope Control System for Atomically
Innovations in Scanning Tunneling Microscope Control Systems for This project will develop a microelectromechanical system (MEMS) platform technology for scanning probe microscope-based, high-speed atomic scale High-throughput fabrication. Initially, it will be used to speed up, by more than 1000 times, today’s Atomically Precise single tip hydrogen depassivation lithography (HDL), enabling commercial fabrication of 2D atomically precise nanoscale devices. Ultimately, it could be used to fabricate Manufacturing 3D atomically precise materials, features, and devices. Graphic image courtesy of University of Texas at Dallas and Zyvex Labs Atomically precise manufacturing (APM) is an emerging disruptive technology precision movement in three dimensions mechanosynthesis (i.e., moving single that could dramatically reduce energy are also needed for the required accuracy atoms mechanically to control chemical and coordination between the multiple reactions) of three dimensional (3D) use and increase performance of STM tips. By dramatically improving the devices and for subsequent positional materials, structures, devices, and geometry and control of STMs, they can assembly of nanoscale building blocks. finished goods. Using APM, every atom become a platform technology for APM and deliver atomic-level control. First, is at its specified location relative Benefits for Our Industry and an array of micro-machined STMs that Our Nation to the other atoms—there are no can work in parallel for high-speed and defects, missing atoms, extra atoms, high-throughput imaging and positional This APM platform technology will accelerate the development of tools and or incorrect (impurity) atoms. Like other assembly will be designed and built. The system will utilize feedback-controlled processes for manufacturing materials disruptive technologies, APM will first microelectromechanical system (MEMS) and products that offer new functional be commercialized in early premium functioning as independent STMs that can qualities and ultra-high performance. -
Soft Machines: Copying Nature's Nanotechnology with Synthetic
From Fantastic Voyage to Soft Machines: two decades of nanotechnology visions (and some real achievements) Richard Jones University of Sheffield Three visions of nanotechnology… 1. Drexler’s mechanical vision 3. Quantum nanodevices 2. Biological/ soft machines … and two narratives about technological progress Accelerating change… …or innovation stagnation? Who invented nanotechnology? Richard Feynman (1918-1988) Theoretical Physicist, Nobel Laureate “There’s Plenty of Room at the Bottom” - 1959 Robert Heinlein? Norio Taniguchi? Coined the term “nanotechnology” in 1974 Don Eigler? 1994 – used the STM (invented by Binnig & Rohrer) to rearrange atoms “Engines of Creation” K. Eric Drexler 1986 The history of technology : increasing precision and miniaturisation Medieval macro- 19th century precision Modern micro-engineering engineering engineering MEMS device, Sandia Late medieval mine Babbage difference engine, pump, Agricola 1832 Where next? Nanotechnology as “the principles of mechanical engineering applied to chemistry” Ideas developed by K.Eric Drexler Computer graphics and simulation Technical objections to Drexler’s vision Drexler’s Nanosystems: More research required Josh Hall: “Noone has ever found a significant error in the technical argument. Drexler’s detractors in the political argument don’t even talk about it.” • Friction • Uncontrolled mechanosynthesis • Thermodynamic and kinetic stability of nanostructures • Tolerance • Implementation path • Low level mechanosynthesis steps “If x doesn’t work, we’ll just try y”, versus an ever- tightening design space. “Any material you like, as long as it’s diamond” • Nanosystems and subsequent MNT work concentrate on diamond – Strong and stiff (though not quite as stiff as graphite) – H-terminated C (111) is stable wrt surface reconstruction • Potential disadvantages – Not actually the thermodynamic ground state (depends on size and shape - clusters can reconstruct to diamond-filled fullerene onions) – Non-ideal electronic properties. -
Molecular Nanotechnology - Wikipedia, the Free Encyclopedia
Molecular nanotechnology - Wikipedia, the free encyclopedia http://en.wikipedia.org/wiki/Molecular_manufacturing Molecular nanotechnology From Wikipedia, the free encyclopedia (Redirected from Molecular manufacturing) Part of the article series on Molecular nanotechnology (MNT) is the concept of Nanotechnology topics Molecular Nanotechnology engineering functional mechanical systems at the History · Implications Applications · Organizations molecular scale.[1] An equivalent definition would be Molecular assembler Popular culture · List of topics "machines at the molecular scale designed and built Mechanosynthesis Subfields and related fields atom-by-atom". This is distinct from nanoscale Nanorobotics Nanomedicine materials. Based on Richard Feynman's vision of Molecular self-assembly Grey goo miniature factories using nanomachines to build Molecular electronics K. Eric Drexler complex products (including additional Scanning probe microscopy Engines of Creation Nanolithography nanomachines), this advanced form of See also: Nanotechnology Molecular nanotechnology [2] nanotechnology (or molecular manufacturing ) Nanomaterials would make use of positionally-controlled Nanomaterials · Fullerene mechanosynthesis guided by molecular machine systems. MNT would involve combining Carbon nanotubes physical principles demonstrated by chemistry, other nanotechnologies, and the molecular Nanotube membranes machinery Fullerene chemistry Applications · Popular culture Timeline · Carbon allotropes Nanoparticles · Quantum dots Colloidal gold · Colloidal -
2 Scalability of the Channel Capacity of Electromagnetic Nano- Networks 10 2.1 Introduction
Exploring the Scalability Limits of Communication Networks at the Nanoscale Thesis submitted in partial fulfillment of the requirements for the degree of Master in Computer Architecture, Networks and Systems by Ignacio Llatser Mart´ı Advisors: Dr. Eduard Alarc´onCot Dr. Albert Cabellos-Aparicio 2011 Nanonetworking Center in Catalunya (N3Cat) Universitat Polit`ecnicade Catalunya Abstract Nanonetworks, the interconnection of nanomachines, will greatly expand the range of applications of nanotechnology, bringing new opportunities in di- verse fields. Following preliminary studies, two paradigms that promise the re- alization of nanonetworks have emerged: molecular communication and nano- electromagnetic communication. In this thesis, we study the scalability of communication networks when their size shrinks to the nanoscale. In particular, we aim to analyze how the performance metrics of nanonetworks, such as the channel attenuation or the propagation delay, scale as the size of the network is reduced. In the case of nano-electromagnetic communication, we focus on the scal- ability of the channel capacity. Our quantitative results show that due to quantum effects appearing at the nanoscale, the transmission range of nanoma- chines is higher than expected. Based on these results, we derive guidelines regarding how network parameters, such as the transmitted power, need to scale in order to keep the network feasible. In molecular communication, we concentrate in a scenario of short-range molecular signaling governed by Fick's laws of diffusion. We characterize its physical channel and we derive analytical expressions for some key perfor- mance metrics from the communication standpoint, which are validated by means of simulation. We also show the differences in the scalability of the obtained metrics with respect to their equivalent in wireless electromagnetic communication. -
Mechanosynthesis of Nanophase Powders M F
Mechanosynthesis of Nanophase Powders M F. Miani F. Maurigh DIEGM University of Udine, Udine, Italy INTRODUCTION THE MECHANOSYNTHESIS PROCESS Among the different processes able to produce nanocrys- The concept of the mechanosynthesis process is very talline powders in bulk quantities, mechanosynthesis, i.e., simple: to seal in a vial some—usually powdered—ma- the synthesis of nanograined powders by means of terials along with grinding media, which are usually balls, mechanical activation, is one of the most interesting from and to reduce the size of the materials by mechanical an industrial point of view. Mechanosynthesis of nano- action, providing at the same time an intimate mixing phase powders is one of the less sophisticated technolo- of the different materials introduced, so close that gies—and, in such a sense, also the most inexpensive—to diffusion and chemical reactivity are greatly enhanced. produce nanophase powders; in fact, it exploits devices For clarity, one could consider a mixture of elemental and processes that have many aspects in common with powders—for simplicity, we could limit to powders of mixing, fine grinding, and comminution of materials. element A and element B—introduced in a cylindrical However, it does have interest for applications, as, in container, the jar of a vibrating mill, with repeated and principle, this is a very low cost process and its potential prolonged impacts imposed by mechanical energy im- for industrial applications is very significant. This article parted to grinding media (Fig. 1). describes -
Nanotechnology and Regulatory Policy: Three Futures
Harvard Journal of Law & Technology Volume 17, Number 1 Fall 2003 NANOTECHNOLOGY AND REGULATORY POLICY: THREE FUTURES Glenn Harlan Reynolds* TABLE OF CONTENTS I. INTRODUCTION..............................................................................180 II. A BEGINNER’S GUIDE TO NANOTECHNOLOGY ............................181 A. How Nanotechnology Works....................................................181 B. What Nanotechnology Can Do.................................................185 III. REGULATORY RESPONSES ..........................................................187 A. “Relinquishment” and Prohibition ..........................................188 1. The Case for Prohibition: Children of Our Minds.................188 2. Problems with Turning a Blind Eye ......................................190 B. Restriction to the Military Sphere ............................................193 1. The Case for “Painting It Black”...........................................193 2. Problems with Military Classification...................................194 C. Modest Regulation and Robust Civilian Research...................197 1. Early Biotechnology Regulation ...........................................198 2. Evaluating the Biotechnology Model....................................199 IV. LESSONS FOR NANOTECHNOLOGY .............................................200 A. Research...................................................................................201 B. Beyond the Lab.........................................................................202 -
Applications of Molecular Communications to Medicine: a Survey
Applications of molecular communications to medicine: a survey L. Felicetti, M. Femminella, G. Reali*, P. Liò Abstract In recent years, progresses in nanotechnology have established the foundations for implementing nanomachines capable of carrying out simple but significant tasks. Under this stimulus, researchers have been proposing various solutions for realizing nanoscale communications, considering both electromagnetic and biological communications. Their aim is to extend the capabilities of nanodevices, so as to enable the execution of more complex tasks by means of mutual coordination, achievable through communications. However, although most of these proposals show how devices can communicate at the nanoscales, they leave in the background specific applications of these new technologies. Thus, this paper shows an overview of the actual and potential applications that can rely on a specific class of such communications techniques, commonly referred to as molecular communications. In particular, we focus on health-related applications. This decision is due to the rapidly increasing interests of research communities and companies to minimally invasive, biocompatible, and targeted health-care solutions. Molecular communication techniques have actually the potentials of becoming the main technology for implementing advanced medical solution. Hence, in this paper we provide a taxonomy of potential applications, illustrate them in some details, along with the existing open challenges for them to be actually deployed, and draw future perspectives. Keywords: molecular communications, nanomedicine, targeted scope, interfacing, control methods L. Felicetti, M. Femminella, and G. Reali are with the Department of Engineering, University of Perugia, Via G. Duranti 93, 06125 Perugia, Italy. Emails: [email protected], [email protected], [email protected].