Applications of Molecular Communications to Medicine: a Survey
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Sensors 2010, 10, 6796-6820; Doi:10.3390/S100706796 OPEN ACCESS Sensors ISSN 1424-8220
Sensors 2010, 10, 6796-6820; doi:10.3390/s100706796 OPEN ACCESS sensors ISSN 1424-8220 www.mdpi.com/journal/sensors Review Intelligent Chiral Sensing Based on Supramolecular and Interfacial Concepts Katsuhiko Ariga 1,2,*, Gary J. Richards 1, Shinsuke Ishihara 1, Hironori Izawa 1,2 and Jonathan P. Hill 1,2 1 World Premier International (WPI) Research Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba 305-0044, Japan 2 Japan Science and Technology Agency, CREST, 1-1 Namiki, Tsukuba 305-0044, Japan * Author to whom correspondence should be addressed; E-Mail: [email protected]; Tel.: +81-29-860-4597; Fax: +81-29-860-4832. Received: 17 June 2010; in revised form: 7 July 2010 / Accepted: 8 July 2010 / Published: 13 July 2010 Abstract: Of the known intelligently-operating systems, the majority can undoubtedly be classed as being of biological origin. One of the notable differences between biological and artificial systems is the important fact that biological materials consist mostly of chiral molecules. While most biochemical processes routinely discriminate chiral molecules, differentiation between chiral molecules in artificial systems is currently one of the challenging subjects in the field of molecular recognition. Therefore, one of the important challenges for intelligent man-made sensors is to prepare a sensing system that can discriminate chiral molecules. Because intermolecular interactions and detection at surfaces are respectively parts of supramolecular chemistry -
Secrecy Capacity and Secure Distance for Diffusion-Based Molecular Communication Systems
SPECIAL SECTION ON WIRELESS BODY AREA NETWORKS Received May 21, 2019, accepted July 25, 2019, date of publication August 1, 2019, date of current version August 22, 2019. Digital Object Identifier 10.1109/ACCESS.2019.2932567 Secrecy Capacity and Secure Distance for Diffusion-Based Molecular Communication Systems LORENZO MUCCHI 1, (Senior Member, IEEE), ALESSIO MARTINELLI 1, SARA JAYOUSI1, STEFANO CAPUTO1, AND MASSIMILIANO PIEROBON2, (Member, IEEE) 1Department of Information Engineering, University of Florence, 50139 Florence, Italy 2Department of Computer Science and Engineering, University of Nebraska-Lincoln, Lincoln, NE 68508, USA Corresponding author: Lorenzo Mucchi (lorenzo.mucchi@unifi.it) This work was supported by the U.S. National Science Foundation under Grant CISE CCF-1816969. ABSTRACT The biocompatibility and nanoscale features of Molecular Communication (MC) make this paradigm, based on molecules and chemical reactions, an enabler for communication theory applications in the healthcare at its biological level (e.g., bimolecular disease detection/monitoring and intelligent drug delivery). However, the adoption of MC-based innovative solutions into privacy and security-sensitive areas is opening new challenges for this research field. Despite fundamentals of information theory applied to MC have been established in the last decade, research work on security in MC systems is still limited. In contrast to previous literature focused on challenges, and potential roadmaps to secure MC, this paper presents the preliminary elements of a systematic approach to quantifying information security as it propagates through an MC link. In particular, a closed-form mathematical expression for the secrecy capacity of an MC system based on free molecule diffusion is provided. Numerical results highlight the dependence of the secrecy capacity on the average thermodynamic transmit power, the eavesdropper's distance, the transmitted signal bandwidth, and the receiver radius. -
Biosensor Laboratory Selected Publications 1. Irina Sorokulova
Biosensor Laboratory Selected Publications 1. Irina Sorokulova, Eric Olsen, Vitaly Vodyanoy, Bacteriophage biosensors for antibiotic resistant bacteria. Expert Rev Med Devices. 2014 Mar;11(2):175-86. doi: 10.1586/17434440.2014.882767. 2. I.Sorokulova, R. Guntupalli, E. Olsen, L. Globa, O. Pustovyy, V. Vodyanoy. Lytic Phage in Biosensing, ECS Transactions, 58 (23) 1-7 (2014) 10.1149/05823.000lecst ©The Electrochemical Society. 3. Jia, H, Pustovyy, OM, Waggoner, P, Beyers, RJ, Schumacher, J, Wildey, C, Barrett, J, Morrison, E, Salibi, N, Denney, TS, Vodyanoy, VJ, Deshpande, G. Functional MRI of the olfactory system in conscious dogs. PLoS One, 9:e86362 (2014). 4. Kyathanahally SP, Jia H, Pustovyy OM, Waggoner P, Beyers R, Schumacher J, Barrett J, Morrison EE, Salibi N, Denney TS, Vodyanoy VJ, Deshpande G. 2014. Anterior- posterior dissociation of the default mode network in dogs. Brain structure & function: 1- 14. 5. Moore T, Globa L, Barbaree J., Vodyanoy V., Sorokulova I. Antagonistic Activity of Bacillus Bacteria against Food-Borne Pathogens. Journal of Probiotics and Health. Vol. 1(3): 1-6 (2013) 6. Vitaly J. Vodyanoy, Yuri Mnyukh, The Physical Nature of "Giant" Magnetocaloric and Electrocaloric Effects, American Journal of Materials Science, Vol. 3 No. 5, 2013, pp. 105-109. doi: 10.5923/j.materials.20130305.01. 7. Moore T, Sorokulova I, Pustovyy O, Globa L, Vodyanoy V (2013). Microscopic evaluation of vesicles shed by rat erythrocytes at elevated temperatures. Journal of Thermal Biology, 38:487-492. 8. Moore T, Sorokulova I, Pustovyy O, Globa L, Pascoe D, Rudisill M, Vodyanoy V. (2013) Microscopic evaluation of vesicles shed by erythrocytes at elevated temperatures. -
Survey on Terahertz Nanocommunication and Networking
1 Survey on Terahertz Nanocommunication and Networking: A Top-Down Perspective Filip Lemic∗, Sergi Abadaly, Wouter Tavernierz, Pieter Stroobantz, Didier Collez, Eduard Alarcon´ y, Johann Marquez-Barja∗, Jeroen Famaey∗ ∗Internet Technology and Data Science Lab (IDLab), Universiteit Antwerpen - imec, Belgium yNaNoNetworking Center in Catalunya (N3Cat), Universitat Politecnica` de Catalunya, Spain zInternet Technology and Data Science Lab (IDLab), Ghent University - imec, Belgium Email: fi[email protected] Abstract—Recent developments in nanotechnology herald Communication and coordination among the nanodevices, nanometer-sized devices expected to bring light to a number of as well as between them and the macro-scale world, will groundbreaking applications. Communication with and among be required to achieve the full promise of such applications. nanodevices will be needed for unlocking the full potential of such applications. As the traditional communication approaches Thus, several alternative nanocommunication paradigms have cannot be directly applied in nanocommunication, several alter- emerged in the recent years, the most promising ones being native paradigms have emerged. Among them, electromagnetic electromagnetic, acoustic, mechanical, and molecular commu- nanocommunication in the terahertz (THz) frequency band is nication [2]. particularly promising, mainly due to the breakthrough of novel In molecular nanocommunication, a transmitting device materials such as graphene. For this reason, numerous research efforts are nowadays targeting THz band nanocommunication releases molecules into a propagation medium, with the and consequently nanonetworking. As it is expected that these molecules being used as the information carriers [3]. Acoustic trends will continue in the future, we see it beneficial to nanocommunication utilizes pressure variations in the (fluid summarize the current status in these research domains. -
Equilibrium Signaling: Molecular Communication Robust to Geometry Uncertainties Bayram Cevdet Akdeniz, Malcolm Egan, Bao Tang
Equilibrium Signaling: Molecular Communication Robust to Geometry Uncertainties Bayram Cevdet Akdeniz, Malcolm Egan, Bao Tang To cite this version: Bayram Cevdet Akdeniz, Malcolm Egan, Bao Tang. Equilibrium Signaling: Molecular Communication Robust to Geometry Uncertainties. 2020. hal-02536318v2 HAL Id: hal-02536318 https://hal.archives-ouvertes.fr/hal-02536318v2 Preprint submitted on 5 Aug 2020 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. 1 Equilibrium Signaling: Molecular Communication Robust to Geometry Uncertainties Bayram Cevdet Akdeniz, Malcolm Egan and Bao Quoc Tang Abstract A basic property of any diffusion-based molecular communication system is the geometry of the enclosing container. In particular, the geometry influences the system’s behavior near the boundary and in all existing modulation schemes governs receiver design. However, it is not always straightforward to characterize the geometry of the system. This is particularly the case when the molecular communication system operates in scenarios where the geometry may be complex or dynamic. In this paper, we propose a new scheme—called equilibrium signaling—which is robust to uncertainties in the geometry of the fluid boundary. In particular, receiver design only depends on the relative volumes of the transmitter or receiver, and the entire container. -
Toward a Wired Ad Hoc Nanonetwork
Toward a Wired Ad Hoc Nanonetwork Oussama Abderrahmane Dambri and Soumaya Cherkaoui INTERLAB, Engineering Faculty, Universite´ de Sherbrooke, Canada Email: fabderrahmane.oussama.dambri, [email protected] Abstract—Nanomachines promise to enable new medical appli- safety to use terahertz frequencies inside the human body for cations, including drug delivery and real time chemical reactions’ medical applications is another problem of electromagnetic detection inside the human body. Such complex tasks need coop- communication at nanoscale, which needs further research. eration between nanomachines using a communication network. Wireless Ad hoc networks, using molecular or electromagnetic- Molecular communication is a bioinspired paradigm that uses based communication have been proposed in the literature to cre- molecules as information carriers instead of electromagnetic ate flexible nanonetworks between nanomachines. In this paper, waves. Molecular communication is used by nature and can we propose a Wired Ad hoc NanoNETwork (WANNET) model be leveraged safely inside the human body. In [4], the authors design using actin-based nano-communication. In the proposed proposed a mobile ad hoc nanonetwork with collision-based model, actin filaments self-assembly and disassembly is used to create flexible nanowires between nanomachines, and electrons molecular communication. This Mobile Ad hoc Molecular are used as carriers of information. We give a general overview of NETwork (MAMNET) employs infectious disease spreading the application layer, Medium Access Control (MAC) layer and a principles using the electrochemical collision between mobile physical layer of the model. We also detail the analytical model nanomachines to transfer information. Another MAMNET of the physical layer using actin nanowire equivalent circuits, system is proposed in [5], by using Forster¨ Resonance Energy and we present an estimation of the circuit component’s values. -
Supramolecular Aggregates As Sensory Ensembles
ChemComm View Article Online FEATURE ARTICLE View Journal | View Issue Supramolecular aggregates as sensory ensembles Cite this: Chem. Commun., 2016, Qian Wang,* Zhao Li, Dan-Dan Tao, Qian Zhang, Peng Zhang, Dai-Ping Guo and 52, 12929 Yun-Bao Jiang* As a new emerging area in chemical sensing, sensing using supramolecular aggregates exhibits unique advantages over that using conventional small-molecule chemical sensors, in terms of high sensitivity Received 22nd July 2016, and selectivity, and the simplicity of the sensory building blocks. This Feature Article outlines the recent Accepted 31st August 2016 research progress made in sensing based on induced supramolecular aggregation–disaggregation. The DOI: 10.1039/c6cc06075g reviewed sensory building blocks, in general, in the form of a small molecular sensor, yet with a much simpler structure, which form aggregates, are those of perylene derivatives, pyrene derivatives, tetra- www.rsc.org/chemcomm phenylethylene derivatives, metallophilic species and metal–organic frameworks. Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Introduction in which four amino acid binding sites are covalently linked withinthesameEDTAframework,andthespecificbio- A molecular chemosensor in general consists of a molecular recognition which relies on multiple weak and less selective recognition site and a signal reporting group, which are either interactions operating in a cooperative manner, sensing using directly connected or linked by a spacer.1 In order to achieve aggregates that hold a more simply designed chemosensor(s) by high sensing performance, for instance, high sensitivity and noncovalent interactions was developed.2 Here the chemosensor- selectivity, the sensory molecule needs to be sophisticatedly like building block itself may exhibit less effective performance designed. -
Innovation Insights 12
INNOVATIONINNOVATION insights insights THE LATEST INNOVATIONS, COLLABORATIONS AND TECHNOLOGY TRANSFER ISSUE 12 JUNE 2019 FROM THE UNIVERSITY OF OXFORD MENTORING OXFORD ENTREPRENEURS Oxford University and Vodafone, helping the bright sparks of Oxford. Enhanced nanoscale Zika viral communication vector vaccine Protection against blast-induced Electrodynamic traumatic brain injury Micro-Manipulator SUBSCRIBE | CONTENTS INNOVATION insights CONTENTS INVENTION Sickle cell screening during pregnancy: A high- Body motion monitoring in MRI and CT imaging: A Electrodynamic micro-manipulator: A technique to throughput non-invasive prenatal testing technique for graphene-based piezoelectric sensor that is compatible manipulate, align and displace non-spherical objects and the diagnosis of sickle-cell disease in the foetus with both MRI and CT imaging 2D nanomaterials while preserving their structural and chemical integrity Biosensors for bacterial detection: Methods for Early gestational diabetes diagnostic: A test using performing remote contamination detection using biomarkers from the placenta to give an early indication of Logical control of CRISPR gene editing system: A fluorescence mothers who are at risk of gestational diabetes control system that allows spatio-temporal activation of CRISPR, based on an engineered RNA guide strand New treatment in chronic lymphocytic Accurate camera relocalisation: An algorithm for estimating leukaemia: A specific use of the drug forodesine to the pose of a 6-degree camera using a single RGB-D frame A novel -
Publications Contents Digest May/2018
IEEE Communications Society Publications Contents Digest May/2018 Direct links to magazine and journal abstracts and full paper pdfs via IEEE Xplore ComSoc Vice President – Publications – Nelson Fonseca Director – Journals – Khaled B. Letaief Director – Magazines – Raouf Boutaba Magazine Editors EIC, IEEE Communications Magazine – Tarek El-Bawab AEIC, IEEE Communications Magazine – Antonio Sanchez-Esquavillas | Ravi Subrahmanyan EIC, IEEE Network Magazine – Mohsen Guizani AEIC, IEEE Network Magazine – David Soldani EIC, IEEE Wireless Communications Magazine – Hamid Gharavi AEIC, IEEE Wireless Communications Magazine – Yi Qian EIC, IEEE Communications Standards Magazine – Glenn Parsons AEIC, IEEE Communications Standards Magazine – Zander Lei EIC, China Communications – Chen Junliang Journal Editors EIC, IEEE Transactions on Communications – Naofal Al-Dhahir EIC, IEEE Journal on Selected Areas In Communications (J-SAC) – Raouf Boutaba EIC, IEEE Communications Letters – O. A. Dobre Editor, IEEE Communications Surveys & Tutorials – Ying-Dar Lin EIC, IEEE Transactions on Network & Service Management (TNSM) – Filip De Turck EIC, IEEE Wireless Communications Letters – Wei Zhang EIC, IEEE Transactions on Wireless Communications – Martin Haenggi EIC, IEEE Transactions on Mobile Communications – Marwan Krunz EIC, IEEE/ACM Transactions on Networking – Eytan Modiano EIC, IEEE/OSA Journal of Optical Communications & Networking (JOCN) – Jane M. Simmons EIC, IEEE/OSA Journal of Lightwave Technology – Peter J. Winzer Co-EICs, IEEE/KICS Journal of Communications -
Nanotechnology Publications: Leading Countries and Blocs
Date: January 29, 2010 Author Note: I provide links and a copy of my working paper (that you may make freely available on your website) and a link to the published paper. Link to working paper: http://www.cherry.gatech.edu/PUBS/09/STIP_AN.pdf Link to published paper: http://www.springerlink.com/content/ag2m127l6615w023/ Page 1 of 1 Program on Nanotechnology Research and Innovation System Assessment Georgia Institute of Technology Active Nanotechnology: What Can We Expect? A Perspective for Policy from Bibliographical and Bibliometric Analysis Vrishali Subramanian Program in Science, Technology and Innovation Policy School of Public Policy and Enterprise Innovation Institute Georgia Institute of Technology Atlanta, GA 30332‐0345, USA March 2009 Acknowledgements: This research was undertaken at the Project on Emerging Nanotechnologies (PEN) and at Georgia Tech with support by the Project on Emerging Nanotechnologies (PEN) and Center for Nanotechnology in Society at Arizona State University ( sponsored by the National Science Foundation Award No. 0531194). The findings contained in this paper are those of the author and do not necessarily reflect the views of Project on Emerging Nanotechnologies (PEN) or the National Science Foundation. For additional details, see http://cns.asu.edu (CNS‐ASU) and http://www.nanopolicy.gatech.edu (Georgia Tech Program on Nanotechnology Research and Innovation Systems Assessment).The author wishes to thank Dave Rejeski, Andrew Maynard, Mihail Roco, Philip Shapira, Jan Youtie and Alan Porter. Executive Summary Over the past few years, policymakers have grappled with the challenge of regulating nanotechnology, whose novelty, complexity and rapid commercialization has highlighted the discrepancies of science and technology oversight. -
Recent Advances in the Field of Bionanotechnology: an Insight Into Optoelectric Bacteriorhodopsin, Quantum Dots, and Noble Metal Nanoclusters
Sensors 2014, 14, 19731-19766; doi:10.3390/s141019731 OPEN ACCESS sensors ISSN 1424-8220 www.mdpi.com/journal/sensors Review Recent Advances in the Field of Bionanotechnology: An Insight into Optoelectric Bacteriorhodopsin, Quantum Dots, and Noble Metal Nanoclusters Christopher Knoblauch 1, Mark Griep 2 and Craig Friedrich 1,* 1 Department of Mechanical Engineering-Engineering Mechanics, Multi-Scale Technologies Institute, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA; E-Mail: [email protected] 2 U.S. Army Research Laboratory, Weapons and Materials Research Directorate, Aberdeen Proving Grounds, MD 21005, USA; E-Mail: [email protected] * Author to whom correspondence should be addressed; E-Mail: [email protected]; Tel.: +1-906-487-1922. External Editor: Yoke Khin Yap Received: 29 August 2014; in revised form: 8 October 2014 / Accepted: 15 October 2014 / Published: 22 October 2014 Abstract: Molecular sensors and molecular electronics are a major component of a recent research area known as bionanotechnology, which merges biology with nanotechnology. This new class of biosensors and bioelectronics has been a subject of intense research over the past decade and has found application in a wide variety of fields. The unique characteristics of these biomolecular transduction systems has been utilized in applications ranging from solar cells and single-electron transistors (SETs) to fluorescent sensors capable of sensitive and selective detection of a wide variety of targets, both organic and inorganic. This review will discuss three major systems in the area of molecular sensors and electronics and their application in unique technological innovations. Firstly, the synthesis of optoelectric bacteriorhodopsin (bR) and its application in the field of molecular sensors and electronics will be discussed. -
2 Scalability of the Channel Capacity of Electromagnetic Nano- Networks 10 2.1 Introduction
Exploring the Scalability Limits of Communication Networks at the Nanoscale Thesis submitted in partial fulfillment of the requirements for the degree of Master in Computer Architecture, Networks and Systems by Ignacio Llatser Mart´ı Advisors: Dr. Eduard Alarc´onCot Dr. Albert Cabellos-Aparicio 2011 Nanonetworking Center in Catalunya (N3Cat) Universitat Polit`ecnicade Catalunya Abstract Nanonetworks, the interconnection of nanomachines, will greatly expand the range of applications of nanotechnology, bringing new opportunities in di- verse fields. Following preliminary studies, two paradigms that promise the re- alization of nanonetworks have emerged: molecular communication and nano- electromagnetic communication. In this thesis, we study the scalability of communication networks when their size shrinks to the nanoscale. In particular, we aim to analyze how the performance metrics of nanonetworks, such as the channel attenuation or the propagation delay, scale as the size of the network is reduced. In the case of nano-electromagnetic communication, we focus on the scal- ability of the channel capacity. Our quantitative results show that due to quantum effects appearing at the nanoscale, the transmission range of nanoma- chines is higher than expected. Based on these results, we derive guidelines regarding how network parameters, such as the transmitted power, need to scale in order to keep the network feasible. In molecular communication, we concentrate in a scenario of short-range molecular signaling governed by Fick's laws of diffusion. We characterize its physical channel and we derive analytical expressions for some key perfor- mance metrics from the communication standpoint, which are validated by means of simulation. We also show the differences in the scalability of the obtained metrics with respect to their equivalent in wireless electromagnetic communication.