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| Hai Lui a Un Nou Can Dan Alat Mulia |HAI LUI AUN NOUUS010016341B2 CAN DAN ALAT MULIA MAN (12 ) United States Patent ( 10 ) Patent No. : US 10 , 016 ,341 B2 Chin et al. (45 ) Date of Patent: Jul 10 , 2018 ( 54 ) SYSTEMS AND DEVICES FOR 17 /006 ; A61J 17 /001 ; A61J 7 /0015 ; A61J CONTROLLING DELIVERY OF BREAST 7 / 0076 ; A61J 11 / 0005 ; A61J 15 /0011 ; A61J 2200 /70 ; G06F 19 / 3406 MILK SUPPLEMENTATION See application file for complete search history . (71 ) Applicant: Elwha LLC , Bellevue , WA (US ) (56 ) References Cited (72 ) Inventors : Hon Wah Chin , Palo Alto , CA (US ); Roderick A . Hyde , Redmond , WA U . S . PATENT DOCUMENTS (US ) ; Elizabeth A . Sweeney , Seattle , 4 ,384 , 288 A 5 / 1983 Walton WA (US ) ; Lowell L . Wood , Jr. , 4 ,687 ,466 A 8 / 1987 Larsson Bellevue , WA (US ) (Continued ) ( 73 ) Assignee : Elwha LLC , Bellevue, WA (US ) OTHER PUBLICATIONS ( * ) Notice : Subject to any disclaimer, the term of this “ 8mm Diaphragm Isolation ” ; ASCO ; accessed on Feb . 24 , 2015 , pp . patent is extended or adjusted under 35 1 - 2 . U . S . C . 154 ( b ) by 345 days . (Continued ) ( 21) Appl. No .: 14 /673 ,456 Primary Examiner — Bradley J Osinski ( 22 ) Filed : Mar. 30 , 2015 Assistant Examiner — Nilay Shah (57 ) ABSTRACT (65 ) Prior Publication Data Systems and devices for controlling delivery of a breast milk US 2016 / 0287481 A1 Oct. 6 , 2016 supplement are described which include a nipple component including aperture ; a guard component attached to the nipple (51 ) Int. Ci. component; a supplement reservoir including a port with a A61J 9 / 00 ( 2006 .01 ) controllable valve , the supplement reservoir adapted to A61 ) 7700 ( 2006 .01 ) contain one or more breast milk supplements , a flow conduit disposed within at least a portion of the nipple component (Continued ) and having a first end in fluid communication with the ( 52 ) U .S . CI. aperture and a second end in fluid communication with the ??? . .. .. .. A61J 9 /00 ( 2013 .01 ) ; A61J 770015 port; a data storage component including a breast milk ( 2013 .01 ) ; A61J 770076 (2013 . 01 ) ; A61J supplement regimen ; and a control unit operably coupled to 13 /00 (2013 . 01 ) ; A61 ) 17 / 006 ( 2015 .05 ) ; the controllable valve and the data storage component and G06F 19 /3456 (2013 .01 ) ; G16H 40 /63 including a microprocessor and circuitry , the circuitry ( 2018 .01 ) ; A61B 10 / 0051 ( 2013 . 01 ) ; A61J including actuation circuitry configured to actuate the con 11 /0005 (2013 .01 ) ; trollable valve to module release of the one or more breast (Continued ) milk supplements based on the breast milk supplement ( 58 ) Field of Classification Search regimen . CPC .. .. A61M 1 / 06 – 1 /068 ; A61M 1 / 007; A61M 2210 / 1007 ; A61J 13 / 00 ; A61J 9 /00 ; A61J 35 Claims, 33 Drawing Sheets 2020 - 2014 - 2080 2000 2010 2034 2032 2016 2012 2050 2040 2030 2060 US 10 ,016 , 341 B2 Page 2 (51 ) Int . Cl. OTHER PUBLICATIONS A61) 13 / 00 ( 2006 .01 ) Argentiere et al. ; " Smart Microfluidics : The Role of Stimuli A61J 17/ 00 ( 2006 .01 ) Responsive Polymers in Microfluidic Devices” ; Advances in G06F 19 / 00 ( 2018 .01 ) Microfluidics ; bearing a date of Mar . 7 , 2012 , pp . 127 - 154 ; In Tech . Ballard et al. ; “ Human Milk Composition : Nutrients and Bioactive G16H 40 / 63 ( 2018 .01 ) Factors” ; National Institute of Health — Pediatr Clin North Am . ; A61B 10 / 00 (2006 .01 ) Feb . 2013 ; pp . 1 - 24 ; vol . 60 , No. 1 ; Elsevier Inc . A61 ) 11 / 00 Barzilay et al . ; “ Micro - Processorbased Improved Ultrasonic Direc ( 2006 .01 ) tion and Range Finder” , International Journal of Computer Science A61J 15 / 00 ( 2006 .01 ) and Information Technologies, accessed on Mar. 5 , 2015 ; pp . 303 - 308 ; vol. 1 , No. 4 . ( 52 ) U . S . CI. Beauchamp et al . , “ Flavor Perception in Human Infants : Develop CPC . A61J 15 / 0011 ( 2013 .01 ) ; A61 ) 2200 / 30 ment and Functional Significance ” ; Digestion ; bearing a date of ( 2013 .01 ) ; A61 ) 2200 /42 (2013 .01 ) ; A61J Mar. 10 , 2011 , pp . 1 - 6 ; vol . 83 ; S . Karger AG , Basel . 2200 / 70 ( 2013 . 01 ) ; A61J 2200 / 74 ( 2013 .01 ) ; Bosch et al. , “ Recent Development in Optical Fiber Biosensors ” ; A61J 2205 /60 (2013 .01 ) ; A61M 2210 / 1007 Sensors ; bearing a date of May 21, 2007; pp . 797 -859 ; vol . 7 ; MDPI. ( 2013 .01 ) ; YO2A 90 / 26 ( 2018 .01 ) Böttner et al .; " New Thermoelectric Components Using Microsystem Technologies ” ; Journal of Microelectromechanical Systems; Jun . 2004 ; pp . 414 -420 ; vol . 13 , No. 3 ; IEEE . ( 56 ) References Cited Cabrera - Rubio et al . , “ The human milk microbiome changes over lactation and is shaped by maternal weight and mode of delivery ” ; U . S . 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A61K 9 / 1694 Collins et al. ; “ Microfluidic flow transducer based on the measure 424 / 439 ment of electrical admittance " ; Lab on a Chip ; bearing a date of 6 , 693 , 513 B2 2 / 2004 Tuttle Aug . 27 , 2003 ; 12 pages ; vol. 4 ; The Royal Society of Chemistry 7 , 101 , 565 B2 9 / 2006 Monte 7 , 411 , 505 B2 8 / 2008 Smith et al. 2003 . 7 , 479 , 886 B2 1 / 2009 Burr “ Compact 2 -way Pinch Valves ” ; ASCO ; pp . 32 - 35 ; accessed Feb . 7 ,569 , 051 B2 8 / 2009 Shachar 24 , 2015 . 7 ,632 ,406 B2 12 / 2009 Wilson et al. “ Conductivity Sensor for various conductivity measurement appli 7 , 731 , 988 B2 6 / 2010 Thomas et al . cations" ; Innovative Sensor Technology ; downloaded Feb . 24 , 8 , 672 , 877 B2 3 / 2014 Gust 2015 ; pp . 1 - 2 . 9 , 561 ,002 B2 . 2 / 2017 Lau Costello et al .; “ A review of the volatiles from the healthy human 2003 /0152612 A1 8 / 2003 Pugliese et al . body ” ; Journal of Breath Research ; bearing a date of Jun . 3 , 2013 ; 2005 / 0277912 Al 12 / 2005 John pp . 1 - 29 ; vol. 8 ; IOP Publishing Ltd . 2005 /0283327 Al 12 / 2005 Bowman et al. “ Drug delivery device solutions” ; PEP micro PEP ; downloaded on 2006 / 0138371 A1 6 / 2006 Garnier Feb . 24 , 2015 ; pp . 1 - 2 ; located at http : / /www . pepmicropep . com 2006 / 0226108 A1 10 / 2006 Dahan et al. markets /medical - surgical /drug -delivery -device -solutions / ; Preci 2007 /0031486 A1 * 2 / 2007 Squashic .. .. 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Wiley & Sons, Ltd . 2011/ 0126770 AL 6 / 2011 Mulder et al . Flaga et al. , “ Pneumatic Valves Based on Magnetic Shape Memory 2012 /0252924 A1 * 10 / 2012 Mahoney C08K 3 / 36 Alloys : Potential Applications” ; 2011 12th International Carpathian 523 / 105 Control Conference (ICCC ) ; downloaded Mar. 4 , 2015 ; pp . 111 2012/ 0277794 A1* 11/ 2012 Kountotsis .. A61B 5 /6802 114 ; IEEE . 606 / 234 Fu et al .; “ TiNi- based thin films in MEMS applications : a review ” ; 2013/ 0270140 A 10 / 2013 Tronson 2014 / 0199680 AL 7 / 2014 Min et al . Sensors and Actuators a Physical ; bearing a date of Feb . 12 , 2004 ; 2014 / 0276167 A1 9 / 2014 Dasgupta et al. pp . 395 - 408 ; vol. 112 ; Elsevier B . V . 2014 /0288466 AL 9 / 2014 Alvarez et al. Futagawa et al . ; " A Miniature Integrated Multimodal Sensor for 2015 /0011858 AL 1 / 2015 Caluser Measuring pH , EC and Temperature for Precision Agriculture ” ; 2015 / 0088304 A1 * 3 / 2015 Ameye .. .. A47J 31 / 404 Sensors ; bearing a date of Apr. 30 , 2012 ; pp . 8338 -8354 ; vol. 12 . 700 / 233 Gutierrez et al ., “ Electrochemically - Based Dose Measurement for 2015 / 0160212 A1 6 / 2015 Maehana et al . Closed -Loop Drug Delivery Applications” ; Transducers ' 11 , 2015 / 0245737 A1 9 / 2015 Chigusa et al. Beijing, China , Jun . 5 - 9 , 2011 ; pp . 2839 - 2842 ; IEEE . 2015 /0283311 A1 * 10 /2015 Alvarez .. A61M 1 / 0031 Hagleitner et al . ; “ Smart single -chip gas sensor microsystem ” ; 604 /514 Nature; Nov . 15 , 2001 ; pp . 293 - 296 ; vol. 414 ; Macmillan Maga 2016 /0120763 AL 5 /2016 Conner et al . zines Ltd . 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